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Your search keyword '"WILKINSON, MARK L."' showing total 34 results
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34 results on '"WILKINSON, MARK L."'

2. Endoscopic retrograde cholangiopancreatography in infantile cholestasis

Author

Wilkinson, Mark L., Mieli-Vergani, Giorgina, Ball, Colin, Portmann, Bernard, and Mowat, Alex P.

Subjects
Bile ducts -- Abnormalities, Cholestasis -- Causes of, Biliary atresia -- Diagnosis, Endoscopic retrograde cholangiopancreatography -- Evaluation, Cholestasis -- Diagnosis, Infants (Newborn) -- Abnormalities
Published
1991

4. Endoscopy: Throat Spray or Sedation?

Author

Pereira, Stephen P, Hussaini, S Hyder, Hanson, Peter J V, Wilkinson, Mark L, and Sladen, Gordon E

Subjects
Aerosols, Male, Conscious Sedation, Lidocaine, Middle Aged, Original Papers, Endoscopy, Gastrointestinal, Patient Satisfaction, Surveys and Questionnaires, Humans, Pharynx, Female, Prospective Studies, Letters to the Editor, Anesthesia, Local
Abstract

Anxious patients tolerate endoscopy poorly. It was proposed that such patients might derive most benefit from sedation, while most non-anxious patients would prefer endoscopy with lignocaine throat spray alone. In a prospective study, 200 outpatients underwent diagnostic endoscopy after receiving one of two detailed information sheets which offered them either the choice between spray or sedation (n = 100) or the same choice but encouraged those who were anxious about endoscopy to choose sedation (n = 100). When given an informed choice, most non-anxious patients prefer not to be sedated most non-anxious patients prefer not to be sedated during diagnostic endoscopy. If patients who are anxious about the procedure are advised to choose sedation, those who nevertheless opt for topical throat spray alone find the endoscopy just as comfortable. If the endoscopy were to be repeated, 73% of the spray group and 77% of the sedation group would make the same choice again. Of 33 patients who chose spray but had been given only sedation for a previous endoscopy, 26 (79%) would choose spray again for a future endoscopy. The choice of spray or sedation should reflect the patient's view as well as that of the endoscopist.

Published
1995

7. Sclerosing mesenteritis involving the pancreas

Author

Phillips, Rosemary H., primary, Carr, Richard A., additional, Preston, Rebecca, additional, Pereira, Stephen P., additional, Wilkinson, Mark L, additional, OʼDonnell, Patrick J., additional, and Thompson, Richard P. H., additional

Published
1999
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10. Endoscopic retrograde cholangiopancreatography in elderly patients

Author

ASHTON, CHARLES E., McNABB, W. ROBIN, WILKINSON, MARK L., and LEWIS, ROGER R.

Subjects
Endoscopic retrograde cholangiopancreatography -- Usage -- Health aspects, Aged -- Health aspects -- Usage, Biliary tract -- Health aspects -- Usage, Gallstones -- Diagnosis, Pancreatic cancer -- Diagnosis, Health, Psychology and mental health, Seniors, Social sciences, Diagnosis, Usage, Health aspects
Abstract

Abstract Background: the presentation of common bile duct disease, value of investigations and treatment outcome in elderly patients undergoing endoscopic retrograde cholangiopancreatography (ERCP) were assessed. Methodology: the clinical presentation, liver [...]

Published
1998

22. Foetal steroid binding protein in British and Japanese women

Author

Iqbal, M. Jawed, Forbes, Alastair, Wilkinson, Mark L., Moore, John W., Williams, Roger, and Bulbrook, Richard D.

Abstract

Abstract. In order to examine the newly-discovered sex-steroid binding protein, foetal steroid binding protein (FSBP) in different populations, its binding characteristics and its level were studied by two-tier column ligand binding assay and enzyme-linked immunosorbent assay (ELISA) respectively. In 10 Japanese premenopausal women, analysis of 5α-dihydrotestosterone (DHT) binding in the Cibacron Blue 3GA-Sepharose 6B portion of the column showed a rising plateau pattern with a mean maximum binding of 31.1 ± 7.41%, whereas of 9 similar British women, 8 displayed unsaturable, non-cooperative binding of 11.6 ± 8.22% (P< 0.01). After partial purification of FSBP in these samples, the protein exhibited saturable binding kinetics, median binding 25 (interquartiles 23–34) and 19 (13–25) nmol DHT/l in Japanese and British women, respectively (P< 0.05). By analyzing FSBP by ELISA in 56 Japanese (45 premenopausal) and 59 British (25 premenopausal) women, higher levels were obtained in the whole Japanese group (P= 0.0016) and in the premenopausal Japanese women (P= 0.018) than in their British counterparts. In both nationalities, FSBP levels were higher in premenopausal women, and there was a significant negative correlation of FSBP with age in both populations, particularly in postmenopausal women. FSBP levels did not correlate with weight, parity, sex hormone binding globulin or albumin levels. The influence of FSBP on free steroid levels remains unclear, but some relationship with ovarian function seems a possibility.

Published
1987
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28. Primary Sclerosing Cholangitis in Childhood

Author

El-Shabrawi, Mortada, primary, Wilkinson, Mark L., additional, Portmann, Bernard, additional, Mieli-Vergani, Giorgina, additional, Chong, Sonny K.F., additional, Williams, Roger, additional, and Mowat, Alex P., additional

Published
1987
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