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217 results on '"WEVER, P. C."'

4. Seroprevalence of SARS-CoV-2 antibodies among healthcare workers in Dutch hospitals after the 2020 first wave: a multicentre cross-sectional study with prospective follow-up

Author

Recanatini, Claudia, GeurtsvanKessel, Corine H., Pas, Suzan D., Broens, Els M., Maas, Martje, van Mansfeld, Rosa, Mutsaers-van Oudheusden, Anne J. G., van Rijen, Miranda, Schippers, Emile F., Stegeman, Arjan, Tami, Adriana, Veldkamp, Karin Ellen, Visser, Hannah, Voss, Andreas, Wegdam-Blans, Marjolijn C. A., Wertheim, Heiman F. L., Wever, Peter C., Koopmans, Marion P. G., Kluytmans, Jan A. J. W., and Kluytmans-van den Bergh, Marjolein F. Q.

Published
2023
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12. Vascular chronic Q fever : quality of life

Author

HAGENAARS, J. C. J. P., WEVER, P. C., SHAMELIAN, S. O. A., VAN PETERSEN, A. S., HILBINK, M., RENDERS, N. H. M., DE JAGER-LECLERCQ, G. L., MOLL, F. L., and KONING, O. H. J.

Published
2015

29. Chronic Q fever-related complications and mortality: data from a nationwide cohort

Author

UMC Utrecht, MS Infectieziekten, Circulatory Health, Infection & Immunity, MS Interne Geneeskunde, van Roeden, S. E., Wever, P. C., Kampschreur, L. M., Gruteke, P., van der Hoek, W., Hoepelman, A. I.M., Bleeker-Rovers, C. P., Oosterheert, J. J., UMC Utrecht, MS Infectieziekten, Circulatory Health, Infection & Immunity, MS Interne Geneeskunde, van Roeden, S. E., Wever, P. C., Kampschreur, L. M., Gruteke, P., van der Hoek, W., Hoepelman, A. I.M., Bleeker-Rovers, C. P., and Oosterheert, J. J.

Published
2019

37. Chronic Q fever: patient and treatment-related factors influencing long-term quality of life

Author

MS Infectieziekten, Unit Opleiding Aios, Circulatory Health, Infection & Immunity, MS Interne Geneeskunde, van Roeden, S. E., Reukers, D. F.M., van Jaarsveld, C. H.M., Kampschreur, L. M., Hoepelman, I. M., Wever, P. C., Bleeker-Rovers, C. P., Oosterheert, J. J., MS Infectieziekten, Unit Opleiding Aios, Circulatory Health, Infection & Immunity, MS Interne Geneeskunde, van Roeden, S. E., Reukers, D. F.M., van Jaarsveld, C. H.M., Kampschreur, L. M., Hoepelman, I. M., Wever, P. C., Bleeker-Rovers, C. P., and Oosterheert, J. J.

Published
2018

38. The effect of measuring serum doxycycline concentrations on clinical outcomes during treatment of chronic Q fever

Author

MS Infectieziekten, Unit Opleiding Aios, MS Interne Geneeskunde, Infection & Immunity, Circulatory Health, van Roeden, S. E., Bleeker-Rovers, C. P., Kampschreur, L. M., de Regt, M. J.A., Windsant, A. Vermeulen, Hoepelman, A. I.M., Wever, P. C., Oosterheert, J. J., MS Infectieziekten, Unit Opleiding Aios, MS Interne Geneeskunde, Infection & Immunity, Circulatory Health, van Roeden, S. E., Bleeker-Rovers, C. P., Kampschreur, L. M., de Regt, M. J.A., Windsant, A. Vermeulen, Hoepelman, A. I.M., Wever, P. C., and Oosterheert, J. J.

Published
2018

41. Value of 18F-FDG PET/CT in diagnosing chronic Q fever in patients with central vascular disease

Author

Hagenaars, J. C J P, Wever, P. C., Vlake, A. W., Renders, N. H M, van Petersen, A. S., Hilbink, M., De Jager-Leclercq, M. G L, Moll, F. L., Koning, O. H J, and Hoekstra, C. J.

Subjects
Sensitivity, Specificity, Internal Medicine, Chronic Q fever, Vascular graft, F-FDGPET/ CT, Aneurysm
Abstract

Background: The aim of this study is to describe the value of 2-deoxy-2-[18F]fluoro-D-glucose positron emission tomography/computed tomography (18F-FDG PET/CT) in diagnosing chronic Q fever in patients with central vascular disease and the added value of18F-FDG PET/CT in the diagnostic combination strategy as described in the Dutch consensus guideline for diagnosing chronic Q fever. Methods:18F-FDG PET/CT was performed in patients with an abdominal aortic aneurysm or aorto-iliac reconstruction and chronic Q fever, diagnosed by serology and positive PCR for Coxiella burnetii DNA in blood and/or tissue (PCR-positive study group). Patients with an abdominal aortic aneurysm or aorto-iliac reconstruction without clinical and serological findings indicating Q fever infection served as a control group. Patients with a serological profile of chronic Q fever and a negative PCR in blood were included in additional analyses (PCR-negative study group). Results: Thirteen patients were evaluated in the PCR-positive study group and 22 patients in the control group.18F-FDG PET/CT indicated vascular infection in 6/13 patients in the PCR-positive study group and 2/22 patients in the control group.18F-FDG PET/CT demonstrated a sensitivity of 46% (95% CI: 23-71%), specificity of 91% (95% CI: 71-99%), positive predictive value of 75% (95% CI:41-93%) and negative predictive value of 74% (95% CI: 55-87%). In the PCR-negative study group,18F-FDG PET/ CT was positive in 10/20 patients (50%). Conclusion: The combination of18F-FDG PET/CT, as an imaging tool for identifying a focus of infection, and Q fever serology is a valid diagnostic strategy for diagnosing chronic Q fever in patients with central vascular disease.

Published
2016

42. Value of 18F-FDG PET/CT in diagnosing chronic Q fever in patients with central vascular disease

Author

Verpleegafd Vaatchirurgie D4 Oost, Circulatory Health, Hagenaars, J. C J P, Wever, P. C., Vlake, A. W., Renders, N. H M, van Petersen, A. S., Hilbink, M., De Jager-Leclercq, M. G L, Moll, F. L., Koning, O. H J, Hoekstra, C. J., Verpleegafd Vaatchirurgie D4 Oost, Circulatory Health, Hagenaars, J. C J P, Wever, P. C., Vlake, A. W., Renders, N. H M, van Petersen, A. S., Hilbink, M., De Jager-Leclercq, M. G L, Moll, F. L., Koning, O. H J, and Hoekstra, C. J.

Published
2016

43. Vascular chronic Q fever : Quality of life

Author

Hagenaars, J. C J P, Wever, P. C., Shamelian, S. O A, Van Petersen, A. S., Hilbink, M., Renders, N. H M, De Jager-Leclercq, G. L., Moll, F. L., Koning, O. H J, Hagenaars, J. C J P, Wever, P. C., Shamelian, S. O A, Van Petersen, A. S., Hilbink, M., Renders, N. H M, De Jager-Leclercq, G. L., Moll, F. L., and Koning, O. H J

Published
2015

44. Vascular chronic Q fever: Quality of life

Author

Verpleegafd Vaatchirurgie D4 Oost, Circulatory Health, Hagenaars, J. C J P, Wever, P. C., Shamelian, S. O A, Van Petersen, A. S., Hilbink, M., Renders, N. H M, De Jager-Leclercq, G. L., Moll, F. L., Koning, O. H J, Verpleegafd Vaatchirurgie D4 Oost, Circulatory Health, Hagenaars, J. C J P, Wever, P. C., Shamelian, S. O A, Van Petersen, A. S., Hilbink, M., Renders, N. H M, De Jager-Leclercq, G. L., Moll, F. L., and Koning, O. H J

Published
2015

45. Chronic Q fever: patient and treatment-related factors influencing long-term quality of life.

Author

Roeden, S E van, Reukers, D F M, Jaarsveld, C H M van, Kampschreur, L M, Hoepelman, I M, Wever, P C, Bleeker-Rovers, C P, and Oosterheert, J J

Subjects
Q fever, QUALITY of life, ANTIBIOTICS, CROSS-sectional method, DRUG side effects
Abstract

Background Chronic Q fever is accompanied by high mortality and morbidity, and requires prolonged antibiotic treatment. Little is known on long-term quality of life (LQOL) in chronic Q fever patients treated with antibiotics. Aim To identify patient and treatment-related factors associated with impaired LQOL in chronic Q fever patients treated with antibiotics, and to assess patients' perception on treatment. Design Cross-sectional study. Methods LQOL was assessed with a validated questionnaire from the Nijmegen Clinical Screening Instrument. Patients' perception on treatment was measured with three newly developed questions. Results We included 64 patients: LQOL was impaired in 55% (n = 35) after a median follow-up of 5 years. Median treatment duration was 27 months. In multivariable analysis, treatment duration was significantly associated with impaired LQOL (OR 1.07; 95%CI 1.02–1.12, P < 0.01 per month increase). Age, gender, number of antibiotic regimens, surgical intervention, complications, diagnostic classification, focus of infection or registration of side effects during treatment were not associated with impaired LQOL. After start of treatment, 17 patients (27%) perceived improvement of their condition. Disadvantages of treatment were experienced on a daily basis by 24 patients (69%) with impaired LQOL and 13 patients (46%) without impaired LQOL (P = 0.04). Conclusions LQOL in chronic Q fever patients treated with antibiotics is impaired in more than half of patients 5 years after diagnosis. Antibiotic treatment duration was the only variable associated with impaired LQOL. The majority of patients experienced disadvantages on a daily basis, highlighting the high burden of disease and treatment. [ABSTRACT FROM AUTHOR]

Published
2018
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46. The effect of measuring serum doxycycline concentrations on clinical outcomes during treatment of chronic Q fever.

Author

Roeden, S E van, Bleeker-Rovers, C P, Kampschreur, L M, Regt, M J A de, Windsant, A Vermeulen, Hoepelman, A I M, Wever, P C, Oosterheert, J J, van Roeden, S E, de Regt, M J A, and Vermeulen Windsant, A

Subjects
CHLOROQUINE, CONFIDENCE intervals, LONGITUDINAL method, MULTIVARIATE analysis, POLYMERASE chain reaction, Q fever, RISK assessment, TREATMENT effectiveness, PROPORTIONAL hazards models, RETROSPECTIVE studies, DOXYCYCLINE, THERAPEUTICS
Abstract

Background: First choice treatment for chronic Q fever is doxycycline plus hydroxychloroquine. Serum doxycycline concentration (SDC) >5 μg/mL has been associated with a favourable serological response, but the effect on clinical outcomes is unknown.Objectives: To assess the effect of measuring SDC during treatment of chronic Q fever on clinical outcomes.Methods: We performed a retrospective cohort study, to assess the effect of measuring SDC on clinical outcomes in patients treated with doxycycline and hydroxychloroquine for chronic Q fever. Primary outcome was the first disease-related event (new complication or chronic Q fever-related mortality); secondary outcomes were all-cause mortality and PCR-positivity. Multivariable analysis was performed with a Cox proportional hazards model, with shared-frailty terms for different hospitals included.Results: We included 201 patients (mean age 68 years, 83% male): in 167 patients (83%) SDC was measured, 34 patients (17%) were treated without SDC measurement. First SDC was >5 μg/mL in 106 patients (63%), all with 200 mg doxycycline daily. In patients with SDC measured, dosage was adjusted in 41% (n = 68), concerning an increase in 64 patients. Mean SDC was 4.1 μg/mL before dosage increase, and 5.9 μg/mL afterwards. SDC measurement was associated with a lower risk for disease-related events (HR 0.51, 95% CI 0.26-0.97, P = 0.04), but not with all-cause mortality or PCR-positivity.Conclusions: SDC measurement decreases the risk for disease-related events, potentially through more optimal dosing or improved compliance. We recommend measurement of SDC and striving for SDC >5 μg/mL and <10 μg/mL during treatment of chronic Q fever. [ABSTRACT FROM AUTHOR]

Published
2018
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49. Een waarschijnlijk geval van difterie

Author

Wever, P. C., Bos, J. C., van den Brekel, M. W. M., de Jong, D., Bovée, L. P. M. J., Kersten, M. J., Schellekens, J. F. P., Kerst, J. M., Other departments, Ear, Nose and Throat, Amsterdam institute for Infection and Immunity, Cancer Center Amsterdam, and Clinical Haematology

Published
2008

50. Twee patienten met de bof

Author

Brummelen, S E van, Vries, E de, Schneeberger, P M, Binnendijk, R S van, Lestrade, P, and Wever, P C

Abstract

Two patients, men aged 17 and 19 years respectively, were admitted with parotitis epidemica and orchitis caused by mumps. The second patient also had meningitis. PCR analysis revealed that, in both cases, the causative agentwas a mumps virus that was genetically related to a wild-type virus responsible for an outbreak in Singapore. This viral strain was also responsible for a mumps outbreak at Hotel School The Hague in September 2004. Both patients were not fully vaccinated. Both patients were from regions in which clustering of patients with clinical signs of mumps has been seen. Interestingly, a number of patients with confirmed mumps had been fully vaccinated. Possible explanations for the increase in mumps cases include low vaccination and immunity levels, primary and secondary vaccine failure and the emergence of genetically disparate mumps viruses.

Published
2007

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