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Complement fixing antibody in animals injected with heat killed tubercle bacilli in oil appears earlier in the lesion at the site of injection than in the blood serum. Complement fixing antibody in an extract prepared by suspending one part by weight of tissue from the local site in five parts of saline is in general in higher concentration than in the blood, for a period of approximately 3 weeks following injection. After this time the serum may show the higher titre. The titre of antibody at the site of injection tends to increase with the quantity of heat killed bacilli injected into the skin, up to a definable maximum. No evidence was found to support the opinion that local accumulation of antibody was caused by fixation of antibody contained in the serum and produced elsewhere in the body, for extracts of lesions produced by the injection of paraffin oil, old tuberculin, and cod liver oil showed no demonstrable antibody, or at most a very low titre, even when the serum titre was high. After reinjection of heat killed tubercle bacilli in oil into rabbits with antibody in the serum, antibody did not appear in the local lesion any earlier than in normal animals similarly injected. These observations give evidence that antibody is formed in the skin at the site of injection of tubercle bacilli.

Twenty-one cases of thyroiditis, generally considered a rare disease, were observed in the Los Angeles area in a period of less than two years. Eight of them were observed at one clinic in the course of six months.Although diagnosis of the disease usually is made hesitantly or apologetically, and misdiagnosis is not uncommon, the clinical pattern is fairly characteristic. Subacute thyroiditis may cause pronounced disability. Treatment with propylthiouracil or roentgen radiation appeared to be the most effective.