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2. RELATION OF RENAL PRESSOR SUBSTANCE TO HYPERTENSION OF HYDRONEPHROTIC RATS

Author

WILLIAMS, JOHN R., WEGRIA, R., and HARRISON, T. R.

Abstract

In the course of investigations concerning the renal pressor substance (Tigerstedt's renin) we have encountered a number of rats with spontaneous hydronephrosis. Such animals are usually found to have an elevation of blood pressure. The following investigations were undertaken to obtain information concerning the mechanism of the rise in blood pressure displayed by these animals: METHODS After anesthesia had been induced by the intraperitoneal injection of pentobarbital sodium, the blood pressure was measured by cannulation of the abdominal aorta with a needle attached to a small bore manometer, heparin being used to prevent clotting. The renal pressor substance was prepared from pig kidneys by precipitation with alcohol and extraction with dilute solution of sodium bicarbonate according to the technic described by Grossman.1Observations of two different types were made. In one series of experiments the sensitivity of hydronephrotic rats to renal pressor substance was compared with that of normal

Published
1938
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14. Increase in pancreatic amylase mediated by glucocorticoid.

Author

Kim YS, Baudendistel LJ, Wegria R, and Kim RE

Subjects
Amylases metabolism, Animals, Blood Glucose, Cycloheximide pharmacology, Dose-Response Relationship, Drug, Insulin pharmacology, Male, Prednisolone antagonists & inhibitors, Rats, Amylases biosynthesis, Pancreas enzymology, Prednisolone pharmacology
Published
1976
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15. Effect of nitroglycerine on coronary circulation and cardiac metabolism.

Author

Oei HH, Hale TH, Kopjas TC, and Wegria R

Subjects
Animals, Dogs, Hemodynamics drug effects, Oxygen Consumption drug effects, Time Factors, Coronary Circulation drug effects, Myocardium metabolism, Nitroglycerin pharmacology
Abstract

Nitroglycerine administered intravenously to dogs under chloralose anesthesia elicits a biphasic effect. During the first phase, it causes an increase in heart rate, a decrease in mean arterial bloodpressure and a rise in cardiac output, coronary blood flow and myocardial oxygen consumption. During the second phase, the heart rate remains elevated and the arterial bloodpressure remains below control, but cardiac output, coronary blood flow and myocardial oxygen consumption decrease to or below control values. During both phases, the myocardial oxygen arteriovenous difference is decreased below its control value because of a rise in the oxygen content of the coronary sinus blood. It is concluded that nitroglycerine first increases the myocardial oxygen consumption less than the coronary blood flow, then may decrease the oxygen consumption more than the coronary flow.

Published
1978

16. Effect of aminophylline on coronary circulation and cardiac metabolism.

Author

Oei HH, Hale TH, Gandhi SS, Pilla TJ, and Wegria R

Subjects
Animals, Dogs, Hemodynamics drug effects, Oxygen blood, Oxygen Consumption drug effects, Aminophylline pharmacology, Coronary Circulation drug effects, Myocardium metabolism
Abstract

Doses of aminophylline commensurate with human doses, administered intravenously to dogs under chloralose anesthesia cause an increase in heart rate, a decrease in mean systemic arterial blood pressure, a rise in cardiac output, coronary blood flow and myocardial oxygen consumption and an increase in the oxygen content of the coronary sinus blood which resulted in a decrease in the coronary oxygen arteriovenous difference as the oxygen content of the arterial blood remained essentially unchanged. This increase in coronary blood flow in the presence of a decrease in arterial blood pressure is obviously due to a decrease in the resistance of the coronary bed, which is probably due, at least partially, to dilatation of the coronary bed. Furthermore, since aminophylline decreases the coronary oxygen arteriovenous difference although it raises the myocardial oxygen consumption, it is concluded that aminophylline increases the coronary blood flow more than the myocardial oxygen consumption.

Published
1977

50. Effect of acute mitral insufficiency of various degrees on mean arterial blood pressure, coronary blood flow cardiac output and oxygen consumption.

Author

WEGRIA R, MUELHEIMS G, JREISSATY R, and NAKANO J

Subjects
Humans, Blood Pressure physiology, Blood Vessels physiology, Cardiac Output, Cardiovascular Physiological Phenomena, Coronary Vessels physiology, Disease, Heart, Heart Diseases, Mitral Valve, Mitral Valve Insufficiency, Myocardium metabolism, Oxygen Consumption
Published
1958
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