1. Network-specific resting-state connectivity changes in the premotor-parietal axis in writer's cramp
- Author
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Tobias Mantel, Christian Dresel, Bernhard Haslinger, Jona Kräenbring, Angela Jochim, Tobias Meindl, Gina Gora-Stahlberg, Maria Berndt, and Yong Li
- Subjects
0301 basic medicine ,Male ,Premotor cortex ,S2, secondary somatosensory cortex ,SMG, supramarginal gyrus ,ROI, region of interest ,PPN, premotor parietal network ,Brain mapping ,lcsh:RC346-429 ,PAT, writer's cramp patients ,Functional connectivity ,0302 clinical medicine ,Cerebellum ,Parietal Lobe ,Basal ganglia ,Neural Pathways ,TIV, total intracranial volume ,Resting state ,SPC, superior parietal cortex ,IC, independent component ,WC, writer's cramp ,Brain Mapping ,medicine.diagnostic_test ,SMA, supplementary motor area ,Writer's cramp ,Parietal lobe ,Motor Cortex ,Regular Article ,v/dSMN, ventral/dorsal sensorimotor network ,Middle Aged ,Magnetic Resonance Imaging ,ICA, independent component analysis ,ddc ,ICN, intrinsic connectivity network ,Dystonia ,medicine.anatomical_structure ,Neurology ,Dystonic Disorders ,FWHM, full width at half maximum ,lcsh:R858-859.7 ,Female ,Sensorimotor Cortex ,Psychology ,Adult ,PMd/v, dorsal/ventral premotor cortex ,CONTR, healthy controls ,Cognitive Neuroscience ,FC, functional connectivity ,lcsh:Computer applications to medicine. Medical informatics ,03 medical and health sciences ,ADDS, arm dystonia disability scale ,medicine ,Humans ,Radiology, Nuclear Medicine and imaging ,WCRS, writer's cramp rating scale ,lcsh:Neurology. Diseases of the nervous system ,M1, primary motor cortex ,PCA, principal component analysis ,Resting state fMRI ,CN, cerebellar network ,SM1, primary sensorimotor cortex ,FoV, field of view ,GM, grey matter ,medicine.disease ,BOLD, blood oxygen level-dependent ,FHD, focal hand dystonia ,IPS, intraparietal sulcus ,BGN, basal ganglia network ,030104 developmental biology ,rsfMRI, resting state functional magnetic resonance imaging ,S1, primary somatosensory cortex ,Neurology (clinical) ,Functional magnetic resonance imaging ,Neuroscience ,030217 neurology & neurosurgery ,Dystonic disorder - Abstract
Background Writer's cramp is a task-specific dystonia impairing writing and sometimes other fine motor tasks. Neuroimaging studies using manifold designs have shown varying results regarding the nature of changes in the disease. Objective To clarify and extend the knowledge of underlying changes by investigating functional connectivity (FC) in intrinsic connectivity networks with putative sensorimotor function at rest in an increased number of study subjects. Methods Resting-state functional magnetic resonance imaging with independent component analysis was performed in 26/27 writer's cramp patients/healthy controls, and FC within and between resting state networks with putative sensorimotor function was compared. Additionally, voxel-based morphometry was carried out on the subjects' structural images. Results Patients displayed increased left- and reduced right-hemispheric primary sensorimotor FC in the premotor-parietal network. Mostly bilaterally altered dorsal/ventral premotor FC, as well as altered parietal FC were observed within multiple sensorimotor networks and showed differing network-dependent directionality. Beyond within-network FC changes and reduced right cerebellar grey matter volume in the structural analysis, the positive between-network FC of the cerebellar network and the basal ganglia network was reduced. Conclusions Abnormal resting-state FC in multiple networks with putative sensorimotor function may act as basis of preexisting observations made during task-related neuroimaging. Further, altered connectivity between the cerebellar and basal ganglia network underlines the important role of these structures in the disease., Highlights • Investigation of FC changes in various sensorimotor ICNs at rest in writer's cramp. • We saw multiple, network-specific FC changes in primary/higher sensorimotor cortices. • This may act as basis of the varying nature of sensorimotor changes during task-fMRI. • Further, findings supporting disrupted cerebellar-basal ganglia interaction were made. • An additional morphometric analysis demonstrated structural cerebellar abnormality.
- Published
- 2018