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634 results on '"WANNER, ADAM"'

3. Conference Report

Author

Coors, Marilyn, Bauer, Larry, Edwards, Kelly, Erickson, Karen, Goldenberg, Aaron, Goodale, John, Goodman, Kenneth, Grady, Christine, Mannino, David, Wanner, Adam, Wilson, Todd, Yarborough, Mark, and Zirkle, Maryan

Published
2017

6. Genome-Wide Study of Percent Emphysema on Computed Tomography in the General Population. The Multi-Ethnic Study of Atherosclerosis Lung/SNP Health Association Resource Study

Author

Manichaikul, Ani, Hoffman, Eric A, Smolonska, Joanna, Gao, Wei, Cho, Michael H, Baumhauer, Heather, Budoff, Matthew, Austin, John HM, Washko, George R, Carr, J Jeffrey, Kaufman, Joel D, Pottinger, Tess, Powell, Charles A, Wijmenga, Cisca, Zanen, Pieter, Groen, Harry JM, Postma, Dirkje S, Wanner, Adam, Rouhani, Farshid N, Brantly, Mark L, Powell, Rhea, Smith, Benjamin M, Rabinowitz, Dan, Raffel, Leslie J, Stukovsky, Karen D Hinckley, Crapo, James D, Beaty, Terri H, Hokanson, John E, Silverman, Edwin K, Dupuis, Josée, O’Connor, George T, Boezen, H Marike, Rich, Stephen S, and Barr, R Graham

Subjects
Biomedical and Clinical Sciences, Cardiovascular Medicine and Haematology, Clinical Sciences, Chronic Obstructive Pulmonary Disease, Human Genome, Emphysema, Lung, Genetics, Cardiovascular, Atherosclerosis, Clinical Research, 2.1 Biological and endogenous factors, Aetiology, Aged, Aged, 80 and over, Female, Follow-Up Studies, Genetic Markers, Genome-Wide Association Study, Genotyping Techniques, Humans, Male, Mannosidases, Middle Aged, N-Acetylglucosaminyltransferases, Nerve Tissue Proteins, Polymorphism, Single Nucleotide, Pulmonary Emphysema, RNA Helicases, Thiolester Hydrolases, Tomography, X-Ray Computed, United States, alpha-Mannosidase, snRNP Core Proteins, emphysema, computed tomography, multiethnic, cohort study, genetic association, Medical and Health Sciences, Respiratory System, Cardiovascular medicine and haematology, Clinical sciences
Abstract

RationalePulmonary emphysema overlaps partially with spirometrically defined chronic obstructive pulmonary disease and is heritable, with moderately high familial clustering.ObjectivesTo complete a genome-wide association study (GWAS) for the percentage of emphysema-like lung on computed tomography in the Multi-Ethnic Study of Atherosclerosis (MESA) Lung/SNP Health Association Resource (SHARe) Study, a large, population-based cohort in the United States.MethodsWe determined percent emphysema and upper-lower lobe ratio in emphysema defined by lung regions less than -950 HU on cardiac scans. Genetic analyses were reported combined across four race/ethnic groups: non-Hispanic white (n = 2,587), African American (n = 2,510), Hispanic (n = 2,113), and Chinese (n = 704) and stratified by race and ethnicity.Measurements and main resultsAmong 7,914 participants, we identified regions at genome-wide significance for percent emphysema in or near SNRPF (rs7957346; P = 2.2 × 10(-8)) and PPT2 (rs10947233; P = 3.2 × 10(-8)), both of which replicated in an additional 6,023 individuals of European ancestry. Both single-nucleotide polymorphisms were previously implicated as genes influencing lung function, and analyses including lung function revealed independent associations for percent emphysema. Among Hispanics, we identified a genetic locus for upper-lower lobe ratio near the α-mannosidase-related gene MAN2B1 (rs10411619; P = 1.1 × 10(-9); minor allele frequency [MAF], 4.4%). Among Chinese, we identified single-nucleotide polymorphisms associated with upper-lower lobe ratio near DHX15 (rs7698250; P = 1.8 × 10(-10); MAF, 2.7%) and MGAT5B (rs7221059; P = 2.7 × 10(-8); MAF, 2.6%), which acts on α-linked mannose. Among African Americans, a locus near a third α-mannosidase-related gene, MAN1C1 (rs12130495; P = 9.9 × 10(-6); MAF, 13.3%) was associated with percent emphysema.ConclusionsOur results suggest that some genes previously identified as influencing lung function are independently associated with emphysema rather than lung function, and that genes related to α-mannosidase may influence risk of emphysema.

Published
2014

13. Lower respiratory tract microbiome composition and community interactions in smokers

Author

Campos, Michael, primary, Cickovski, Trevor, additional, Fernandez, Mitch, additional, Jaric, Melita, additional, Wanner, Adam, additional, Holt, Gregory, additional, Donna, Elio, additional, Mendes, Eliana, additional, Silva-Herzog, Eugenia, additional, Schneper, Lisa, additional, Segal, Jonathan, additional, Amador, David Moraga, additional, Riveros, Juan Daniel, additional, Aguiar-Pulido, Vanessa, additional, Banerjee, Santanu, additional, Salathe, Matthias, additional, Mathee, Kalai, additional, and Narasimhan, Giri, additional

Published
2022
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19. Review of Florida red tide and human health effects

Author

Fleming, Lora E., Kirkpatrick, Barbara, Backer, Lorraine C., Walsh, Cathy J., Nierenberg, Kate, Clark, John, Reich, Andrew, Hollenbeck, Julie, Benson, Janet, Cheng, Yung Sung, Naar, Jerome, Pierce, Richard, Bourdelais, Andrea J., Abraham, William M., Kirkpatrick, Gary, Zaias, Julia, Wanner, Adam, Mendes, Eliana, Shalat, Stuart, Hoagland, Porter, Stephan, Wendy, Bean, Judy, Watkins, Sharon, Clarke, Tainya, Byrne, Margaret, and Baden, Daniel G.

Published
2011
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25. Hospitalized Exacerbations of COPD: Risk Factors and Outcomes in the ECLIPSE Cohort

Author

Müllerova, Hana, Maselli, Diego J., Locantore, Nicholas, Vestbo, Jørgen, Hurst, John R., Wedzicha, Jadwiga A., Bakke, Per, Agusti, Alvar, Anzueto, Antonio, Ivanov, Yavor, Kostov, Kosta, Bourbeau, Jean, Fitzgerald, Mark, Hernández, Paul, Killian, Kieran, Levy, Robert, Maltais, Francois, O´Donnell, Denis, Krepelka, Jan, Vestbo, Jørgen, Wouters, Emiel F. M., Quinn, Dean, Bakke, Per, Kosnik, Mitja, Agusti, Alvar, Feschenko, Yuri, Gavrisyuk, Volodymyr, Yashina, Lyudmila, MacNee, William, Singh, S. David, Wedzicha, Jadwiga, Anzueto, Antonio, Braman, Sidney, Casaburi, Richard, Celli, Bart, Giessel, Glenn, Gotfried, Mark, Greenwald, Gary, Hanania, Nicola, Mahler, Don, Make, Barry, Rennard, Stephen, Rochester, Carolyn, Scanlon, Paul, Schuller, Dan, Sciurba, Frank, Sharafkhaneh, Amir, Siler, Thomas, Silverman, Edwin, Wanner, Adam, Wise, Robert, Zu Wallack, Richard, Bakke, Per, Coxson, Harvey, Edwards, Lisa, Lomas, David, MacNee, William, Silverman, Edwin, Tal-Singer, Ruth, Vestbo, Jørgen, Yates, Julie, Agusti, Alvar, Calverley, Peter, Celli, Bartolome, Crim, Courtney, Miller, Bruce, MacNee, William, Rennard, Stephen, Tal-Singer, Ruth, and Wouters, Emiel

Published
2015
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41. Norepinephrine transport by the extraneuronal monoamine transporter in human bronchial arterial smooth muscle cells

Author

Horvath, Gabor, Sutto, Zoltan, Torbati, Aliza, Conner, Gregory E., Salathe, Matthias, and Wanner, Adam

Subjects
Vasoconstriction -- Research, Biological sciences
Abstract

Inhaled glucocorticosteroids (GSs) cause acute, [alpha.sub.1]-adrenoreceptor (AR)-mediated bronchial vasoconstriction. After release from sympathetic nerves, norepinephrine (NE) must be taken up into cells for deactivation by intracellular enzymes. Because postsynaptic cellular NE uptake is steroid sensitive, GSs could increase NE concentrations at [alpha.sub.1]-AR, causing vasoconstriction. We therefore evaluated mRNA expression of different NE transporters in human bronchial arterial smooth muscle and pharmacologically characterized NE uptake into these cells. RT-PCR demonstrated mRNA expression of the extraneuronal monoamine transporter (EMT) and organic cation transporter 1 (OCT-1). Fluorometric uptake assay showed time (within minutes)- and concentration-dependent NE uptake by freshly isolated bronchial arterial smooth muscle cells (SMC) with an estimated [K.sub.m] of 240 [micro]M. Corticosterone and O-methylisoprenaline (1 [micro]M each), but not desipramine, inhibited NE uptake, a profile indicative of NE uptake by EMT, but not OCT-1. Budesonide and methylprednisolone inhibited uptake with I[C.sub.50] values of 0.9 and 5.6 [micro]M, respectively. Corticosterone's action was reversible and not sensitive to RU-486 (GS receptor antagonist), actinomycin D (transcription inhibitor), or cycloheximide (protein synthesis inhibitor). Corticosterone made membrane impermeant by coupling to BSA also blocked NE uptake. Immunocytochemistry indicated a specific membrane binding site for corticosterone on bronchial arterial SMC. These data demonstrate that although human bronchial arterial SMC express OCT-1 and EMT, EMT is the predominant plasma membrane transporter for NE uptake. This process can be inhibited by GSs, likely via a specific membrane binding site. This non-genomic GS action (increasing NE concentrations at al-AR) could explain acute bronchial vasoconstriction caused by inhaled GSs. vasoconstriction; glucocorticosteroids; budesonide; non-genomic; plasma membrane binding site

Published
2003

49. Losartan Rescues Inflammation-related Mucociliary Dysfunction in Relevant Models of Cystic Fibrosis

Author

Kim, Michael D., primary, Baumlin, Nathalie, additional, Yoshida, Makoto, additional, Polineni, Deepika, additional, Salathe, Sebastian F., additional, David, Joseph K., additional, Peloquin, Charles A., additional, Wanner, Adam, additional, Dennis, John S., additional, Sailland, Juliette, additional, Whitney, Philip, additional, Horrigan, Frank T., additional, Sabater, Juan R., additional, Abraham, William M., additional, and Salathe, Matthias, additional

Published
2020
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