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10. Recent developments in the immunopathology of COVID-19

Author

Zhang, Huan‐ping; https://orcid.org/0000-0003-2263-6774, Sun, Yuan‐li, Wang, Yan‐fen, Yazici, Duygu, Azkur, Dilek; https://orcid.org/0000-0002-4396-9087, Ogulur, Ismail, Azkur, Ahmet Kursat; https://orcid.org/0000-0002-5597-8917, Yang, Zhao‐wei; https://orcid.org/0000-0002-1805-4360, Chen, Xiao‐xue, Zhang, Ai‐Zhi, Hu, Jia‐qian, Liu, Guang‐Hui, Akdis, Mübeccel, Akdis, Cezmi A; https://orcid.org/0000-0001-8020-019X, Gao, Ya‐dong; https://orcid.org/0000-0003-1251-7608, Zhang, Huan‐ping; https://orcid.org/0000-0003-2263-6774, Sun, Yuan‐li, Wang, Yan‐fen, Yazici, Duygu, Azkur, Dilek; https://orcid.org/0000-0002-4396-9087, Ogulur, Ismail, Azkur, Ahmet Kursat; https://orcid.org/0000-0002-5597-8917, Yang, Zhao‐wei; https://orcid.org/0000-0002-1805-4360, Chen, Xiao‐xue, Zhang, Ai‐Zhi, Hu, Jia‐qian, Liu, Guang‐Hui, Akdis, Mübeccel, Akdis, Cezmi A; https://orcid.org/0000-0001-8020-019X, and Gao, Ya‐dong; https://orcid.org/0000-0003-1251-7608

Abstract

There has been an important change in the clinical characteristics and immune profile of Coronavirus disease 2019 (COVID-19) patients during the pandemic thanks to the extensive vaccination programs. Here, we highlight recent studies on COVID-19, from the clinical and immunological characteristics to the protective and risk factors for severity and mortality of COVID-19. The efficacy of the COVID-19 vaccines and potential allergic reactions after administration are also discussed. The occurrence of new variants of concerns such as Omicron BA.2, BA.4, and BA.5 and the global administration of COVID-19 vaccines have changed the clinical scenario of COVID-19. Multisystem inflammatory syndrome in children (MIS-C) may cause severe and heterogeneous disease but with a lower mortality rate. Perturbations in immunity of T cells, B cells, and mast cells, as well as autoantibodies and metabolic reprogramming may contribute to the long-term symptoms of COVID-19. There is conflicting evidence about whether atopic diseases, such as allergic asthma and rhinitis, are associated with a lower susceptibility and better outcomes of COVID-19. At the beginning of pandemic, the European Academy of Allergy and Clinical Immunology (EAACI) developed guidelines that provided timely information for the management of allergic diseases and preventive measures to reduce transmission in the allergic clinics. The global distribution of COVID-19 vaccines and emerging severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants with reduced pathogenic potential dramatically decreased the morbidity, severity, and mortality of COVID-19. Nevertheless, breakthrough infection remains a challenge for disease control. Hypersensitivity reactions (HSR) to COVID-19 vaccines are low compared to other vaccines, and these were addressed in EAACI statements that provided indications for the management of allergic reactions, including anaphylaxis to COVID-19 vaccines. We have gained a depth knowledge and

Published
2023

11. Recent developments in the immunopathology of COVID ‐19

Author

Zhang, Huan‐ping, primary, Sun, Yuan‐li, additional, Wang, Yan‐fen, additional, Yazici, Duygu, additional, Azkur, Dilek, additional, Ogulur, Ismail, additional, Azkur, Ahmet Kursat, additional, Yang, Zhao‐wei, additional, Chen, Xiao‐xue, additional, Zhang, Ai‐Zhi, additional, Hu, Jia‐qian, additional, Liu, Guang‐Hui, additional, Akdis, Mübeccel, additional, Akdis, Cezmi A., additional, and Gao, Ya‐dong, additional

Published
2022
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12. Recent developments in the immunopathology of COVID-19

Author

Gao, Ya-dong, primary, Zhang, Huan-ping, additional, Sun, Yuan-li, additional, Wang, Yan-fen, additional, Yazici, Duygu, additional, Azkur, Dilek, additional, Ogulur, Ismail, additional, AZKUR, Ahmet Kursat, additional, Yang, Zhaowei, additional, Chen, Xiao-xue, additional, Hu, Jia-qian, additional, Liu, Guanghui, additional, Akdis, Mübeccel, additional, Akdis, Cezmi, additional, and Zhang, Ai-zhi, additional

Published
2022
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14. Geographical statistical assessments of carbon fluxes in terrestrial ecosystems of China: Results from upscaling network observations

Author

Zhu, Xian-Jin, Yu, Gui-Rui, He, Hong-Lin, Wang, Qiu-Feng, Chen, Zhi, Gao, Yan-Ni, Zhang, Yi-Ping, Zhang, Jun-Hui, Yan, Jun-Hua, Wang, Hui-Min, Zhou, Guang-Sheng, Jia, Bing-Rui, Xiang, Wen-Hua, Li, Ying-Nian, Zhao, Liang, Wang, Yan-Fen, Shi, Pei-Li, Chen, Shi-Ping, Xin, Xiao-Ping, Zhao, Feng-Hua, Wang, Yu-Ying, Tong, Cheng-Li, Fu, Yu-Ling, Wen, Xue-Fa, Liu, Ying-Chun, Zhang, Lei-Ming, Zhang, Li, Su, Wen, Li, Sheng-Gong, and Sun, Xiao-Min

Published
2014
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15. Recent developments in the immunopathology of COVID‐19.

Author

Zhang, Huan‐ping, Sun, Yuan‐li, Wang, Yan‐fen, Yazici, Duygu, Azkur, Dilek, Ogulur, Ismail, Azkur, Ahmet Kursat, Yang, Zhao‐wei, Chen, Xiao‐xue, Zhang, Ai‐Zhi, Hu, Jia‐qian, Liu, Guang‐Hui, Akdis, Mübeccel, Akdis, Cezmi A., and Gao, Ya‐dong

Subjects
SARS-CoV-2, MULTISYSTEM inflammatory syndrome in children, COVID-19, POST-acute COVID-19 syndrome, MAST cell disease, COVID-19 pandemic
Abstract

There has been an important change in the clinical characteristics and immune profile of Coronavirus disease 2019 (COVID‐19) patients during the pandemic thanks to the extensive vaccination programs. Here, we highlight recent studies on COVID‐19, from the clinical and immunological characteristics to the protective and risk factors for severity and mortality of COVID‐19. The efficacy of the COVID‐19 vaccines and potential allergic reactions after administration are also discussed. The occurrence of new variants of concerns such as Omicron BA.2, BA.4, and BA.5 and the global administration of COVID‐19 vaccines have changed the clinical scenario of COVID‐19. Multisystem inflammatory syndrome in children (MIS‐C) may cause severe and heterogeneous disease but with a lower mortality rate. Perturbations in immunity of T cells, B cells, and mast cells, as well as autoantibodies and metabolic reprogramming may contribute to the long‐term symptoms of COVID‐19. There is conflicting evidence about whether atopic diseases, such as allergic asthma and rhinitis, are associated with a lower susceptibility and better outcomes of COVID‐19. At the beginning of pandemic, the European Academy of Allergy and Clinical Immunology (EAACI) developed guidelines that provided timely information for the management of allergic diseases and preventive measures to reduce transmission in the allergic clinics. The global distribution of COVID‐19 vaccines and emerging severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) variants with reduced pathogenic potential dramatically decreased the morbidity, severity, and mortality of COVID‐19. Nevertheless, breakthrough infection remains a challenge for disease control. Hypersensitivity reactions (HSR) to COVID‐19 vaccines are low compared to other vaccines, and these were addressed in EAACI statements that provided indications for the management of allergic reactions, including anaphylaxis to COVID‐19 vaccines. We have gained a depth knowledge and experience in the over 2 years since the start of the pandemic, and yet a full eradication of SARS‐CoV‐2 is not on the horizon. Novel strategies are warranted to prevent severe disease in high‐risk groups, the development of MIS‐C and long COVID‐19. [ABSTRACT FROM AUTHOR]

Published
2023
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28. 专家笔谈：资源环境热点问题

Author

SUN Hong-lie, null 孙鸿烈, null 郑度, null 夏军, null 陈发虎, null 成升魁, null 沈镭, null 王艳芬, null 林家彬, null 江源, null 董锁成, null 崔彬, null 左其亭, null 雷加强, null 何希吾, null 闵庆文, null 李秀彬, null 康跃虎, ZHENG Du, XIA Jun, CHEN Fa-hu, CHENG Sheng-kui, SHEN Lei, WANG Yan-fen, LIN Jia-bin, JIANG Yuan, DONG Suo-cheng, CUI Bin, ZUO Qi-ting, LEI Jia-qiang, HE Xi-wu, MIN Qing-wen, LI Xiu-bin, and KANG Yue-hu

Published
2018

32. Multi‐model analysis of climate impacts on plant photosynthesis in China during 2000–2015

Author

Yan, Hao, primary, Wang, Shao‐Qiang, additional, Wang, Jun‐Bang, additional, Cao, Yun, additional, Xu, Ling‐Ling, additional, Wu, Men‐Xin, additional, Cheng, Lu, additional, Mao, Liu‐Xi, additional, Zhao, Feng‐Hua, additional, Zhang, Xian‐Zhou, additional, Liu, Yun‐Fen, additional, Wang, Yan‐Fen, additional, Chen, Shi‐Ping, additional, Li, Ying‐Nian, additional, Han, Shi‐Jie, additional, Zhou, Guo‐Yi, additional, Zhang, Yi‐Ping, additional, and Shugart, Herman H., additional

Published
2019
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34. MEMS-based low-frequency piezoelectric vibration energy harvester

Author

李朋伟 Li Peng-wei, 桑胜波 Sang Sheng-bo, 李刚 Li Gang, 刘颖 Liu Ying, and 王艳芬 Wang Yan-fen

Subjects
Microelectromechanical systems, Vibration, Engineering, business.industry, Acoustics, Low frequency, business, Piezoelectricity, Atomic and Molecular Physics, and Optics, Energy harvester, Electronic, Optical and Magnetic Materials
Published
2014

39. E2F1 induces TINCR transcriptional activity and accelerates gastric cancer progression via activation of TINCR/STAU1/CDKN2B signaling axis

Author

Xu, Tong-Peng, primary, Wang, Yan-Fen, additional, Xiong, Wei-Liang, additional, Ma, Pei, additional, Wang, Wen-Yu, additional, Chen, Wen-Ming, additional, Huang, Ming-De, additional, Xia, Rui, additional, Wang, Rong, additional, Zhang, Er-Bao, additional, Liu, Yan-Wen, additional, De, Wei, additional, and Shu, Yong-Qian, additional

Published
2017
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42. Pulmonary enteric adenocarcinoma: a study of the clinicopathologic and molecular status of nine cases

Author

Wang, Cai-Xia, Liu, Biao, Wang, Yan-Fen, Zhang, Ru-Song, Yu, Bo, Lu, Zhen-Feng, Shi, Qun-Li, and Zhou, Xiao-Jun

Subjects
Adult, Male, Lung Neoplasms, DNA Mutational Analysis, Adenocarcinoma of Lung, Genes, erbB-1, Adenocarcinoma, Middle Aged, Real-Time Polymerase Chain Reaction, Immunohistochemistry, digestive system diseases, Proto-Oncogene Proteins p21(ras), Proto-Oncogene Proteins, Mutation, Biomarkers, Tumor, ras Proteins, Humans, Original Article, Female, Aged
Abstract

Pulmonary enteric adenocarcinoma (PEAC), a extremely rare variant of primary invasive adenocarcinoma of the lung, was recognized by the international multidisciplinary classification of lung adenocarcinoma which was proposed by the International Association for the Study of Lung Cancer (IASLC), the American Thoracic Society (ATS), and the European Respiratory Society (ERS) published in early 2011. Histologically, PEAC is considered to be mainly composed of tall columnar cells arranged in an irregular glandular cavity or cribriform pattern with extensive central necrosis which show high resemblance to that of intestinal epithelia and colorectal carcinomas. Immunohistochemically, PEAC can not only expresses typical proteins common to lung primaries but is positive for at least one intestinal markers, such as CDX2, cytokeratin (CK) 20, MUC2, therefore, the differentiation of primary PEACs from metastatic colorectal cancers can be challenging. In this study, we report 9 cases of PEAC and a panel of immunohistochemical protein markers of CK7, CK20, thyroid transcription factor 1 (TTF-1), Napsin A, MUC2 and villin was analyzed with the comparison of 20 metastatic colorectal carcinomas (MCRs), and 20 typical primary adenocarcinomas (tPACs). As was expected, CK7 expression was documented in all 9 PEACs and 20 tPCAs while CK20 was significantly more prevalent in adenocarcinoma that originated from colorectal. Additionally, we evaluate the classical mutations of EGFR, KRAS in the 9 cases of PEACs, it turned out that all tumors were EGFR-wild and KRAS-wild types, which confirmed that PEAC has a separate phenotype from usual pulmonary adenocarcinoma.

Published
2014

45. Approaches of climate factors affecting the spatial variation of annual gross primary productivity among terrestrial ecosystems in China

Author

Zhu, Xian-Jin, primary, Yu, Gui-Rui, additional, Wang, Qiu-Feng, additional, Gao, Yan-Ni, additional, He, Hong-Lin, additional, Zheng, Han, additional, Chen, Zhi, additional, Shi, Pei-Li, additional, Zhao, Liang, additional, Li, Ying-Nian, additional, Wang, Yan-Fen, additional, Zhang, Yi-Ping, additional, Yan, Jun-Hua, additional, Wang, Hui-Min, additional, Zhao, Feng-Hua, additional, and Zhang, Jun-Hui, additional

Published
2016
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46. Oncocytic papillary renal cell carcinoma: a clinicopathological study emphasizing distinct morphology, extended immunohistochemical profile and cytogenetic features

Author

Xia, Qiu-Yuan, Rao, Qiu, Shen, Qin, Shi, Shan-Shan, Li, Li, Liu, Biao, Zhang, Jin, Wang, Yan-Fen, Shi, Qun-Li, Wang, Jian-Dong, Ma, Heng-Hui, Lu, Zhen-Feng, Yu, Bo, Zhang, Ru-Song, and Zhou, Xiao-Jun

Subjects
Adult, Male, Chromosomes, Human, Y, DNA Mutational Analysis, Racemases and Epimerases, Trisomy, Middle Aged, Proto-Oncogene Proteins c-met, Immunohistochemistry, Kidney Neoplasms, Predictive Value of Tests, Cytogenetic Analysis, Biomarkers, Tumor, Adenoma, Oxyphilic, Humans, Vimentin, Original Article, Female, Neprilysin, Carcinoma, Renal Cell, Chromosomes, Human, Pair 7, In Situ Hybridization, Fluorescence, Aged, Chromosomes, Human, Pair 17
Abstract

Papillary renal cell carcinoma (PRCC) is traditionally classified into type 1 and type 2. Recently, an oncocytic variant of PRCC has been described. We report a series of 6 oncocytic renal papillary tumors (OPRCC) which tended to occur in older patients (mean, 56.8 years) with a male preference (male-to-female ratio is 5:1). All 6 patients are alive with no evidence of disease after initial resection, showing an indolent clinical behavior. Histologically, tumors exhibited predominant papillary structure with delicate fibrovascular cores. Papillae were lined by single layers of cells with large, deeply eosinophilic and finely granular cytoplasms and round regular nucleus. The phagocytosis of tumor cells was frequently and evidently seen in our cases that hemosiderin-laden tumor cells and foamy tumor cells were noticed in five and four cases respectively. All tumors were immunoreactive for racemase, vimentin, CD10, and MET and negative for CD117. While E-cadherin, EMA, and cytokeratin 7 exhibited variable immunopositivity. FISH analysis was performed in five of six cases and found heterogeneous results. Trisomy of chromosomes 7 was found in three cases and trisomy of chromosomes 17 in two cases. Loss of chromosome Y was noted in one of four tumors in male patients. MET gene status was also investigated by direct sequencing in all 6 cases and found no distinct mutation in any case. These results suggest that OPRCC shows distinct morphology, indolent clinical behavior, and similar immunohistochemical and cytogenetic features with PRCC, seems to be a variant in the PRCC group. Whether the strong expression of MET indicates a potential therapeutic target is still unknown and requires further investigation in clinical trials.

Published
2013

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