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4. Study on the Configuration of Knowledge Hiding Behaviors in Social Q&A Community Based on FsQCA

Author

Lu Xinyuan, Xu Xiaoqing, and Wang Xuelin

Subjects
knowledge hiding behaviors, Bibliography. Library science. Information resources
Abstract

[Purpose/significance]Knowledge hiding behavior is not only detrimental to the generation of individual knowledge, but also affects the healthy development of social Q&A communities. Exploring the causes of users’ knowledge hiding behaviors in social question-and-answer communities is of great significance to enrich relevant theories of user behaviors in social question-and-answer communities and guide the optimization of platforms. [Method/process] From the perspective of configuration, based on the person-environment matching theory, the fuzzy-set qualitative comparative analysis method (fsQCA) was used to analyze 157 valid samples collected from the questionnaire. The combined effects of value congruence, interpersonal similarity, needs-supplies fit based on external motivations, needs-supplies fit based on internal motivations and demands-abilities fit on knowledge hiding behaviors were explored. [Result/conclusion] To obtain the combination path of high and low degree knowledge hiding behaviors, this study finds that demand matching plays a key role in knowledge hiding behaviors. Through comparative analysis, it is found that users are more inclined to knowledge hiding and reduce knowledge hiding behaviors, it is necessary to strengthen the matching of various conditions.

Published
2022
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8. Murine hepatoma treatment with mature dendritic cells stimulated by Trichinella spiralis excretory/secretory products

Author

Ding Jing, Liu Xiaolei, Tang Bin, Bai Xue, Wang Yang, Li Shicun, Li Jian, Liu Mingyuan, and Wang Xuelin

Subjects
trichinella spiralis, excretory/secretory products, dendritic cells, h22, Infectious and parasitic diseases, RC109-216
Abstract

Excretory/Secretory Products (ESPs) of the nematode Trichinella spiralis contain antitumor-active substances that inhibit tumor growth. Mature dendritic cells (DCs) play a critical role in the antitumor immunity of the organism. As pathogen-derived products, it ought to be discussed whether T. spiralis ESPs will reduce the antitumor effect of mature DCs from the host before it is applied to patients’ tumors. Therefore, the aim of this work was to evaluate the immunological effect of DCs stimulated by T. spiralis ESPs in H22 tumor-bearing mice. H22 tumor model mice in this study were randomly divided into four groups according to the treatment: PBS control group, ESP group, DCs group, and DCs stimulated with T. spiralis ESP (ESP+DCs group). The antitumor effect was evaluated by tumor inhibition rate and cytokine detection using ELISA. The results showed significant inhibition in tumor growth in the ESP+DCs, DCs and ESP groups when compared with the PBS control group (p

Published
2020
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13. Regulation of host immune cells and cytokine production induced by Trichinella spiralis infection

Author

Song Yining, Xu Jing, Wang Xuelin, Yang Yong, Bai Xue, Pang Jianda, Wang Xinrui, Yu Mingchuan, Liu Mingyuan, Liu Xiaolei, and Sun Shumin

Subjects
trichinella spiralis, meso scale discovery, cytokines, immunoregulation, Infectious and parasitic diseases, RC109-216
Abstract

The nematode Trichinella spiralis can cause immunoregulation during the early phase of infection. However, previous studies are still insufficient for a full understanding of this phenomenon and its underlying mechanism. In this study, immune cells and cytokine profiles of T. spiralis infected mice were examined by Meso Scale Discovery (MSD) and flow cytometry. The MSD results of the spleen showed that Th1 immunity was inhibited from 6 h to 6 days post-infection (dpi) and the level of Th2 immune response was significantly increased at 6 dpi. The mesenteric lymph node showed a Th1/Th2 mixed immune response from 3 dpi to 6 dpi with a downtrend of Th1 at 6 dpi. Flow cytometry analysis showed that the proportion of Th1 cells of T cells was decreased significantly at 6 h after infection, the proportion of Th2 cells was markedly increased, indicating that Th1 immunity was significantly inhibited at 6 h after infection, and a hybrid immune response based on Th2 type was presented from 30 h to 6 dpi. The immunoregulation effects observed during this study have provided a better understanding of the development of the immune response induced by Trichinella infection.

Published
2019
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43. Toll-like receptor activation by helminths or helminth products to alleviate inflammatory bowel disease

Author

Song YanXia, Liu XiaoLei, Wang Feng, Zhao Ying, Wu XiuPing, Wang XueLin, Sun ShuMin, Wu ZhiLiang, and Liu MingYuan

Subjects
Toll Like Receptors, Helminth, Inflammatory Bowel Disease, Infectious and parasitic diseases, RC109-216
Abstract

Abstract Helminth infection may modulate the expression of Toll like receptors (TLR) in dendritic cells (DCs) and modify the responsiveness of DCs to TLR ligands. This may regulate aberrant intestinal inflammation in humans with helminthes and may thus help alleviate inflammation associated with human inflammatory bowel disease (IBD). Epidemiological and experimental data provide further evidence that reducing helminth infections increases the incidence rate of such autoimmune diseases. Fine control of inflammation in the TLR pathway is highly desirable for effective host defense. Thus, the use of antagonists of TLR-signaling and agonists of their negative regulators from helminths or helminth products should be considered for the treatment of IBD.

Published
2011
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