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The purpose of this study was to explore the related research progress of ocular complications (OCs) caused by type 2 diabetes mellitus (T2DM), tear and tarsal function, and the application of deep learning (DL) in the diagnosis of diabetes and OCs caused by it, to provide reference for the prevention and control of OCs in T2DM patients. This study reviewed the pathogenesis and treatment of diabetes retinopathy, keratopathy, dry eye disease, glaucoma, and cataract, analyzed the relationship between OCs and tear function and tarsal function, and discussed the application value of DL in the diagnosis of diabetes and OCs. Diabetes retinopathy is related to hyperglycemia, angiogenic factors, oxidative stress, hypertension, hyperlipidemia, and other factors. The increase in water content in the corneal stroma leads to corneal relaxation, loss of transparency, and elasticity, and can lead to the occurrence of corneal lesions. Dry eye syndrome is related to abnormal stability of the tear film and imbalance in neural and immune regulation. Elevated intraocular pressure, inflammatory reactions, atrophy of the optic nerve head, and damage to optic nerve fibers are the causes of glaucoma. Cataract is a common eye disease in the elderly, which is a visual disorder caused by lens opacity. Oxidative stress is an important factor in the occurrence of cataracts. In clinical practice, blood sugar control, laser therapy, and drug therapy are used to control the above eye complications. The function of tear and tarsal plate will be affected by eye diseases. Retinopathy and dry eye disease caused by diabetes will cause dysfunction of tear and tarsal plate, which will affect the eye function of patients. Furthermore, DL can automatically diagnose and classify eye diseases, automatically analyze fundus images, and accurately diagnose diabetes retinopathy, macular degeneration, and other diseases by analyzing and processing eye images and data. The treatment of T2DM is difficult and prone to OCs, which seriously threatens the normal life of patients. The occurrence of OCs is closely related to abnormal tear and tarsal function. Based on DL, clinical diagnosis and treatment of diabetes and its OCs can be carried out, which has positive application value.

Background: To observe the short-term outcome of plasma adsorption PA therapy in amyotrophic lateral sclerosis (ALS). Methods: 28 cases of ALS patients were recruited in this study, of which 20 were male and 8 were female with a mean age of 53.21±9.07 years and the average course of 33±23.35 months. The clinical manifestations were limb weakness (N=27), muscular atrophy (N=27), muscular tremor (N=5), dysphagia (N=12) and dysarthria (N=12). The clinical data of the patients recruited were graded by Amyotrophic Lateral Sclerosis Functional Rating Scale Revised (ALSFRSR) : 40 (N=5). All patients received PA therapy once a week for three successive times after examining the conditions of blood coagulation and virus infection. PA therapy was supplemented with neurotrophic therapy meanwhile. All patients' clinical manifestations and scores of ALSFRSR before treatment and one week after treatment were evaluated and compared. The levels of serum superoxide dismutase (SOD), interleukin-10 (IL-10), serum creatine kinase (CK) and lactate dehydrogenase (LDH) before and after treatment were compared. Results: After PA therapy, 14 patients have improved obviously in muscle strength, 4 patients in hypermyotonia partially, 3 patients in muscular tremor, 5 patients in dysarthria, 3 patients in salivation to some extent and 2 patients in swallowing function. The score of ALSFRSR after PA treatment (31.89±10.36) was remarkably higher than that before PA treatment (30.68±10.52) (P

Nickel-based superalloy (GH4169) and Si3N4 ceramics were connected by AgCuTi composite active filler and high purity W foil which acts as interlayer. The effects of temperature on the microstructure evolution and mechanical properties of GH4169/ Si3N4 brazed joint were systematically studied. The results show that the effective connection of GH4169/Si3N4 brazed joint can be realized by using AgCuTi+W composite filler. The microstructure of the joint is GH4169/TiNi3+TiCu+TiCu2+Ag(s, s)+Cu(s, s)+W+TiN+Ti5Si3/Si3N4. When the brazing temperature is low, the Ti element in liquid filler diffuses to less of the ceramic interface with the filler, and no obvious reaction layer is formed； when the brazed temperature increases to 880 ℃, Ti is enriched on the ceramic side, forming a thickness of 2 μm TiN and Ti5Si3 reaction layer. At this time, the shear strength of the joint is the highest, reaching 190.9 MPa. With the increase in brazing temperature, the content of Ti-Cu compound，which is a brittle compound, increases and the mechanical properties of the joint are greatly reduced. The fracture results show that during the shear process, the crack initiates in the interlayer, and then diffuses into the Si3N4 ceramic matrix， and finally breaks on the side of Si3N4 ceramic.

ObjectiveThe risk assessment model of fatty liver accumulation in zebrafish larvae was established to identify the hepatotoxicity hazards of plasticizer butyl benzyl phthalate （BBP） using Di （2-ethylhexyl） phthalate （DEHP） and dibutyl phthalate （DBP） as positive control samples. This model was used to identify hepatotoxicity of butyl benzyl phthalate （BBP）.MethodsThe fatty liver signal intensity and expression of peroxisome proliferator activated receptor （PPAR） target gene CD36 in zebrafish liver after DEHP and DBP exposure were analyzed， and the hepatotoxicity model of zebrafish larvae was preliminarily constructed， which was used to evaluated the hepatotoxicity of BBP. In addition， liver density analysis， TG quantitative detection of zebrafish larvae and liver pathological examination of adult zebrafish were used to further verify the reliability of the model. The benchmark dose method （BMD） was used to derive the point of departure.ResultsDEHP and DBP showed significant risk of fatty liver induction （both P

The popularity of TikTok has sparked short video studies in global academia. Whereas in China, the market for short video platforms is already matured, which has seen numerous research publications. However, an overall review of short video research is still absent. Using the methods of science mapping and thematic analysis, we summarized the research and review articles from Web of Science Core Collection and CNKI (CSSCI and CSCD) from the past two decades. The main findings are: 1) There are four main stages in the development of short video studies and each of them is tightly related to the market growth; 2) Four main perspectives (media, economic, cultural and discursive) of short video studies with 12 clusters of core issues have emerged, and the visibility that short videos bring to ordinary people is the fundamental viewpoint of many studies; 3) Currently, the short video studies are going broader and deeper, attracting scholars from different academic backgrounds, and multiple methods are applied in the studies; 4) The papers from WoS and CNKI share some similarities but show more differences in the research issues, subjects and methods. We pointed out the limitations of present studies and possibilities of future research.

Abstract Background Bone grafting is an important surgical procedure to reconstruct alveolar bone defects in patients with cleft lip and palate. Polyphosphate (PolyP) is a physiological polymer present in the blood, primarily in platelets. PolyP plays a role as a phosphate source in bone calcium phosphate deposition. Moreover, the cleavage of high-energy bonds to release phosphates provides local energy necessary for regenerative processes. In this study, polyP is complexed with calcium to form Calcium polyP microparticles (Ca-polyP MPs), which were shown to have osteoinductive properties in preclinical studies. The aim of this study was to evaluate the feasibility, safety, and osteoinductivity of Ca-polyP MPs, alone or in combination with BCP, in a first-in-human clinical trial. Methods This single-blinded, parallel, prospective clinical pilot study enrolled eight adolescent patients (mean age 18.1: range 13–34 years) with residual alveolar bone cleft. Randomization in two groups (four receiving Ca-polyP MPs only, four a combination of Ca-polyP MPs and biphasic calcium phosphate (BCP)) was performed. Patient follow-up was 6 months. Outcome parameters included safety parameters and close monitoring of possible adverse effects using radiographic imaging, regular blood tests, and physical examinations. Osteoinductivity evaluation using histomorphometric analysis of biopsies was not possible due to COVID restrictions. Results Due to surgical and feasibility reasons, eventually, only 2 patients received Ca-polyP MPs, and the others the combination graft. All patients were assessed up to day 90. Four out of eight were able to continue with the final assessment day (day 180). Three out of eight were unable to reach the hospital due to COVID-19 restrictions. One patient decided not to continue with the study. None of the patients showed any allergic reactions or any remarkable local or systematic side effects. Radiographically, patients receiving Ca-polyP MPs only were scored grade IV Bergland scale, while patients who got the BCP/Ca-polyP MPs combination had scores ranging from I to III. Conclusions Our results indicate that Ca-polyP MPs and the BCP/Ca-polyP MPs combination appear to be safe graft materials; however, in the current setting, Ca-polyP MPs alone may not be a sufficiently stable defect-filling scaffold to be used in alveolar cleft repair. Trial registration Indonesian Trial Registry under number INA-EW74C1N by the ethical committee of Faculty of Medicine, Hasanuddin University, Makassar, Indonesia with code number 1063/UN4.6.4.5.31/PP36/2019 .

Microplastic is a global pollutant widely existing in the marine and terrestrial environments. The potential health effects of microplastics in food have attracted more and more attentions based on the continuous research. A comprehensive understanding of microplastics in food is very important for food safety and human health. In this paper, the analysis methods, occurrence, exposure and toxicity of microplastics in food are reviewed and the urgent problems needed to be solved are put forward to provide reference for food safety related research.

Objective To evaluate the clinical efficacy and safety of apatinib in the treatment of advanced breast cancer(ABC) patients refractory to multiline treatments. Methods We retrospectively analyzed the clinical data of 29 ABC patients after the failure of multi-line treatments. Patients were treated with apatinib 500 mg/d orally. The clinical efficacy and adverse effects were evaluated. Symptomatic treatment and nursing care were given when the adverse effects were ≥grade Ⅲ and apatinib was suspended if not get relieved. When the adverse effects were ≤gradeⅠ, apatinib was administrated with reduced dosage of 250mg/d. Results Among 29 patients, there was no case with complete remission, 11(37.9%) patients with partial remission (PR), 13(44.8%) cases with stable disease (SD) and 5(17.2%) patients with progressive disease (PD). The disease control rate (PR+SD) was 82.8% (24/29). The median progression-free survival time (mPFS) was 126 days. The most common adverse effects were secondary hypertension(27.59%), hand-foot syndrome(20.69%), Secondary proteinuria(17.24%), nausea and fatigue(13.79%), Secondary oral mucositis(17.24%) and diarrhea(10.24%). Most of the side effects were degreeⅠ-Ⅱ. Log-rank univariate analysis showed a mPFS of 267 days for Luminal B(HER2-) ABC patients and 126 days for triple-negative group, compared with 33 days for HER2+ ABC patients (P=0.057). Patients with secondary hypertension or transient proteinuria had significantly longer mPFS than those without these adverse effects (P=0.025, P=0.058). Cox regression analysis identified molecular typing, secondary hypertension and proteinuria as the independent influence factors for mPFS of ABC patients treated with apatinib. Conclusion Apatinib has relatively high DCR and PFS in the treatment of Luminal B (HER2-) and triple-negative MBC patients, and adverse reactions could be controlled.

TiZrHfNbMo high-entropy alloy and titanium matrix composite were vacuum brazed using carbon nanotubes reinforced AgCuTi composite filler. Microstructure and mechanical properties of the joints were systematically studied by X-ray diffractometer, scanning electron microscopy, energy spectrum and universal testing machine. The results show that the joints brazed at different temperatures from 820 °C to 910 °C for 15 min are successfully connected. The microstructure of the joint is composed of Ag(s,s), Cu(s,s), Ti(s,s), CuTi, ZrCu and CuTi2, the base material elements are fully diffused in the joint. When the brazing holding time is fixed, the shear strength of the joint at room temperature increases first and then decreases with the increase of brazing temperature. The formation of a certain amount of Ti-Cu intermetallic compounds widens the thickness of the reaction layer and improves the strength of the joint, while the formation of excessive Ti-Cu intermetallic compounds weakens the joint ability to relieve stress through plastic deformation, leading to a significant reduction in the joint strength. The best welded joint is obtained when the brazing temperature is 850 ℃ and the holding time is 15 min. The shear strength is up to 146 MPa, and the fracture mode of the shear fracture of the joint is brittle fracture.

With the rapid development of online shopping, how to explore the value of online reviews, so as to give full play to their role in potential users’ purchasing decisions. Based on text mining and quantitative analysis, this paper studies the sentiment analysis of online reviews on B2C shopping website. The main attributes of commodity or service are extracted based on the order of word frequency in the online reviews. Text analysis method is used to judge the relationship between attributes of commodity or service and its emotional words. The fine-grained sentimental polarity and intensity of attributes are identified to analyze users’ concerns and preferences. The research shows that users pay more attention to the configuration and after-sales service of mobile, and have a positive sentimental orientation to most of attributes, especially unlocking function, hand feeling attribute and logistics service; and have a neutral sentimental orientation towards the attributes of battery and memory, and a negative sentimental orientation towards the membrane of mobile phone. The results can provide a reference for consumers to make purchasing decisions, for enterprises to improve product quality, and for shopping platform to optimize service.

In fluorosis-endemic areas, exposure to high levels of fluoride causesneurotoxicity such as lowered intelligence and cognitive impairment. Oxidativedamage is critical to pathophysiologic processes of fluoride intoxication, andneurotoxicity of fluoride may be associated with oxidative stress. In previousstudies, maize purple plant pigment (MPPP), which was rich in anthocyanins,showed a strong scavenging activity in vitro and invivo. The present study aimed to determine whether treatment withMPPP can alleviate fluoride-induced oxidative damage in rat brain. After 3months of experiment, brain tissues were assayed for oxidative stress variables,histological and Western blotting examinations. Our results showed that MPPPreduced the elevated malondialdehyde levels, increased superoxide dismutaseactivity, and further attenuated histopathological alterations and mitigatedneuronal apoptosis. Importantly, MPPP also reversed changes in Bax and Bcl-2.Therefore, it was speculated that MPPP protects brain tissue from fluoridetoxicity through its antioxidant capacity.

The cerebrospinal fluid content was examined for concentrations of S100 protein and neuron-specific enolase (NSE) in two diseases, Kawasaki disease (KD) with aseptic meningitis (1-3 months) and purulent meningitis (PM), to determine whether or not these measuremets could be used in early diagnosis. The content of cerebrospinal fluid S100 protein of KD with aseptic meningitis and PM were significantly higher than those in the control group. There was also a difference between KD and purulent meningitis (PM). The concentration of NSE was highest in the encephalitis group, which was statistically different from control group. However, there was no difference between the KD and control groups. The levels of S100 protein and NSE of KD with aseptic meningitis were lower than those in PM, indicating that the extent of neuronal damage is significantly lower than of the enchephalitis group. The area under the curve (AUCs) of the receiver operating characteristic (ROC) curve for S100 and NSE were both 0.972. The S100 threshold was 0.4315, the sensitivity was 92.1%, and the specificity was 100%, while the NSE threshold was 9.325, sensitivity 92.1%, and specificity 90%. The combined detection of NSE and S100 levels in the cerebrospinal fluid can be used for the differential diagnosis of KD with aseptic meningitis and purulent meningitis.

This study included job autonomy and task dependence into the category of job characteristic factors, and expected to find out boundary conditions of leader creativity expectations affecting employee creativity. By sending questionnaires to 35 teams, 402 subordinates’ matching data were obtained and empirically analyzed. The results show that leader creativity expectations has a significant positive impact on employee creativity, and intrinsic motivation plays a significant mediating role in the relationship between them. Job autonomy positively moderates the relationship between leader creativity expectations and intrinsic motivation, and then enhances the indirect effect of leader creativity expectations on employee creativity through intrinsic motivation. Task dependence negatively moderates the relationship between leader creativity expectations and intrinsic motivation, and weakenes the indirect effect of leader creativity expectations through intrinsic motivation. The study enriches the relevant research framework and has practical significance for management practice.

In order to synchronize various collection terminals with each other and synchronize two- channel in the same collection terminal in acquisition system of seam seismic data，a distributed two-channel synchronous acquisition system of seam seismic data was designed. The system applies a weak signal conditioning circuit to improve signal-to-noise ratio of seismic signal, and uses eight-channel synchronization sampling core to realize synchronization sampling of two-channel in the same collection terminal．A clock synchronization system is constructed which is composed of GPS receiver, digital phase lock loop and STM32 main controller. The adaptive oscillator model drift correction algorithm is used to predict and estimate temperature-drift characteristic and aging characteristic of oven controlled crystal oscillator, so as to realize clock synchronization and time synchronization of various collection terminals in coal mines. The test results show that the system realizes distributed synchronous acquisition of multi-channel seismic signal, the accuracy of synchronization between the different data collection terminals is better than 10 μs within 8 hours continuous work in underground coal mine.

The relevance of the study is conditioned by the role of relations between Kazakhstan and China within the framework of the SCO. To a large extent, the SCO contributed to the development of relations between China and Central Asia. Currently, China enjoys good relations with the countries of Central Asia, often cooperates in various fields, and also often exchanges top-level leaders and promotes each other’s development. Gradually formed a new concept of security, based on a common win-win cooperation and win-win results and contributed to the achievement of common interests. Understanding the international strategic status of Central Asia and the relations between China and Central Asia will help us understand the current strategic intentions of the Central Asian countries and adjust the strategic relations between China and Central Asia. Kazakhstan as an important country in Central Asia and as a regional power, plays an important role in the political and economic structure of Central Asia and even in the international arena. Therefore, China is actively developing close relations and cooperation with Kazakhstan. Key words: Kazakhstan-Chinese relations, Shanghai Cooperation Organization, Central Asia, cooperation.