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Using recycled aggregates to prepare geopolymer concrete plays an essential role in reducing dependence on natural resources and solving the problem of waste accumulation. However, the application of geopolymer recycled aggregate concrete (GRC) has been greatly limited due to the defects in the quality of recycled aggregates and the limitations of the brittleness of concrete materials. Therefore, the work is dedicated to improving GRC properties and exploring the mechanism of action of steel fiber (SF) and nano-Al2O3. In this study, calcined gangue, slag, fly ash, and recycled aggregate were used as raw materials, the influence of SFs (0–1.25 vol%) was first explored by single factor analysis, and on this basis, the effect of nano-Al2O3 (NA) (0–2 wt%) on the GPC performance of SF was studied. The microstructure of GRC was analyzed by scanning electron microscopy. The test results showed that adding SF could significantly improve the splitting tensile and flexural strength of GRC, among which 0.75 vol% is the most excellent. However, the increase in compressive strength could be more apparent. The addition of NA can make up for the lack of SF in improving compressive performance. When NA content is 1 wt%, the version of GRC is most apparent. Adding 1% NA has the most significant advance in GRC performance. The microstructure analysis showed that the NA could promote the polymerization reaction, generate more gel, and make the contact interface between SF and matrix more compact, thus improving the strength of GRC.

Background and purpose: Thyroid hormone and its receptors are closely related to breast cancer. Thyroid receptor-interacting protein 6 (TRIP6) may promote the occurrence and development of breast cancer by interacting with thyroid receptor. This study aimed to investigate the role of TRIP6 in breast cancer and its possible mechanism. Methods: Immunohistochemical staining was used to detect the expressions of TRIP6 and the transcription factor forkhead box C1 (FOXC1) in 268 breast cancer tissues, their matched adjacent tissues and 80 benign fibroadenoma tissues that were resected in Shandong Cancer Hospital from January 2011 to December 2013. COX proportional hazards regression model and Kaplan-Meier method were used to analyze the survival prognosis of breast cancer patients. The expressions of TRIP6 and FOXC1 in normal breast epithelial cells MCF-10A and breast cancer cells (BT474, MCF7 and MDA-MB-231) were detected by Western blot. MDA-MB-231 cells were transfected with TRIP6 si-RNA and si-control respectively, and cell proliferation was detected by clone formation experiment and cell counting kit-8 (CCK-8) experiment. Cell invasion was detected by transwell cell experiment. Cell migration was detected by cell scratch experiment. Western blot was used to detect relative expression of FOXC1 protein. Results: The positive expression rates of TRIP6 and FOXC1 in breast cancer tissues were 85.08% and 88.06%, respectively, which were higher than those in benign fibroadenoma (25.00% and 15.00%) and paracancerous tissues (55.97% and 62.31%) (all P

Posttraumatic stress disorder (PTSD) is a psychiatric disorder that is associated with long-lasting memories of traumatic experiences. Extinction and discrimination of fear memory have become therapeutic targets for PTSD. Newly developed optogenetics and advanced in vivo imaging techniques have provided unprecedented spatiotemporal tools to characterize the activity, connectivity, and functionality of specific cell types in complicated neuronal circuits. The use of such tools has offered mechanistic insights into the exquisite organization of the circuitry underlying the extinction and discrimination of fear memory. This review focuses on the acquisition of more detailed, comprehensive, and integrated neural circuits to understand how the brain regulates the extinction and discrimination of fear memory. A future challenge is to translate these researches into effective therapeutic treatment for PTSD from the perspective of precise regulation of the neural circuits associated with the extinction and discrimination of fear memories. [ABSTRACT FROM AUTHOR]

Background and purpose: Both domestic and foreign guidelines recommend the use of radionuclide as sentinel lymph node (SLN) biopsy (SLNB) tracer, however this technique has not been popularized in China for a variety of reasons. Mitoxantrone hydrochloride injection for tracing (MHI), a new strategy to identify lymph nodes, has not been tested for axillary node staging in breast cancer. This multicenter, self-controlled, non-inferiority trial aimed to evaluate the differences between MHI and radionuclide in SLNB tracing. Methods: The trial was conducted across 7 hospitals from December 2019 to December 2020. Patients with early-stage breast cancer received MHI and radionuclide (technetium 99 labeled sulfur colloid, 99mTc-Sc) as SLN tracers during the surgery. The number of SLNs detected and sentinel node detection rates of MHI and radionuclide were counted to evaluate differences in the tracing effects between the two tracers. Results: SLN detection rates of MHI and radionuclide were 96.9% (370/382) and 97.4% (372/382), respectively, with no significant difference (P>0.05). SLNs were co-detected by both tracers in 362 (94.7%) patients; 16 (4.1%) had adverse events possibly related to the trial drugs. Conclusion: In this study, it was found that the lymphatic tracing ability of MHI was not inferior to that of radionuclide. Meanwhile, the use of MHI does not require special instrument/ equipment assistance. [ABSTRACT FROM AUTHOR]

The application of all‐inorganic perovskite CsPbBr3 nanocrystal glasses recently has enjoyed increasing and diverse attention due to their excellent optical properties. However, a full understanding of their formation process and mechanism still remains uncharted. In an attempt to develop and improve the properties of these glasses, it is significant to explore the formation of CsPbBr3 nanocrystals (NCs) in it. Herein, a borophosphate‐based precursor glass with bright blue emission was prepared by melt quenching, and CsPbBr3 NCs were precipitated in it by water induction; the glass powders' photoluminescence gradually changed from blue to green (478–525 nm). It is proven that the blue luminescence originated from the combination of CsBr and oxygen vacancies in the glass, and the crystal transformation mechanism of CsBr to CsPbBr3 in glass is proposed; the potential application in anti‐counterfeiting is explored based on its special properties. The findings of this study are significant to the basic research for the CsPbBr3 NCs glasses, and also contribute new insights toward their application in different fields. [ABSTRACT FROM AUTHOR]