1. Spatial resolution enhancement using deep learning improves chest disease diagnosis based on thick slice CT.
- Author
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Yu, Pengxin, Zhang, Haoyue, Wang, Dawei, Zhang, Rongguo, Deng, Mei, Yang, Haoyu, Wu, Lijun, Liu, Xiaoxu, Oh, Andrea, Abtin, Fereidoun, Prosper, Ashley, Ruchalski, Kathleen, Wang, Nana, Zhang, Huairong, Li, Ye, Lv, Xinna, Liu, Min, Zhao, Shaohong, Li, Dasheng, Hoffman, John, Aberle, Denise, Liang, Chaoyang, Qi, Shouliang, and Arnold, Corey
- Abstract
CT is crucial for diagnosing chest diseases, with image quality affected by spatial resolution. Thick-slice CT remains prevalent in practice due to cost considerations, yet its coarse spatial resolution may hinder accurate diagnoses. Our multicenter study develops a deep learning synthetic model with Convolutional-Transformer hybrid encoder-decoder architecture for generating thin-slice CT from thick-slice CT on a single center (1576 participants) and access the synthetic CT on three cross-regional centers (1228 participants). The qualitative image quality of synthetic and real thin-slice CT is comparable (p = 0.16). Four radiologists accuracy in diagnosing community-acquired pneumonia using synthetic thin-slice CT surpasses thick-slice CT (p 0.99). For lung nodule detection, sensitivity with thin-slice CT outperforms thick-slice CT (p 0.05). These findings indicate the potential of our model to generate high-quality synthetic thin-slice CT as a practical alternative when real thin-slice CT is preferred but unavailable.
- Published
- 2024