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2. Visualization of low molecular weight factor VIII purified in the presence of benzamidine

Author

E.P. Kang, G. Rock, and W.H. Cruickshank

Subjects
Weight factor, medicine.medical_treatment, Amidines, Factor VIII inhibitor assay, Benzamidine, Polyethylene Glycols, chemistry.chemical_compound, hemic and lymphatic diseases, Freezing, medicine, Chemical Precipitation, Humans, Polyacrylamide gel electrophoresis, Factor VIII, Protease, Chromatography, Chemistry, Hematology, Single band, Protease inhibitor (biology), Benzamidines, Molecular Weight, Biochemistry, Clotting time, Electrophoresis, Polyacrylamide Gel, Blood Coagulation Tests, Peptide Hydrolases, medicine.drug
Abstract

The low molecular weight component of human Factor VIII (VIII:C) has been visualized on polyacrylamide gel as a single band (Mr 140,000) following purification in the presence of 1 mM benzamidine, a protease inhibitor. The protein eluted from this single band shortened the clotting time of the human Factor VIII inhibitor assay. Following reduction of the VIII:C component with 2-mercaptoethanol, a single, stainable band was obtained having Mr 48,000. These results suggest that the retention of the molecular integrity of VIII:C, and its reactions with protein stains, is enhanced by the presence of protease inhibitors.

Published
1980

3. Haematology and Haemophilia

Author

E. Vaugh, L. Sjamsoedin-Visser, C. Louijou, H.H. Brackmann, M. Blombäck, T. Rosemberg, T. Abe, A. Testi, G. Giamarelos, D.A. McClure, L. Capozzi, P.H. Lambert, F. Etzel, P. Hofmann, N. Ciavarella, A. Aronstam, G. Martin, C. Bastianini, W. Altendorf, P. Arends, K.M. da Motta, A.M. Sabbatini, R. Kotischke, Peter H Levine, A.H. Sutor, H. Beeser, Ervin Gebauer, P. Tittley, C. Espinosa, K. Ackermann, H. Roessler, B. Killackey, J. Eibl, J. Martin-Villar, Aaron M. Josephson, D. Heinrich, M.H. Maurer, M. Kazama, F. Querol, Y. Laurian, M. Benali, F. Agrestini, T. Goodwin, H. Schwinn, G.F. Savidge, F. Feldmann, Monteiro Marhino, A. Sagripanti, H. Egli, G. Kumpe, C.J. Cornell, Martin J. Inwood, J.J. Noy, L. Villa, B. Schlier, M.G. Maynard, F. Amoros, K. Koch, S. Stenbjerg, E. Pinori, N. Heimburger, J. Barbara-Branco, S.G. Resnik, C. Smit, Theis Bacher, S. Lopaciuk, L.M. Aledort, Ch. Beck, Ionia McDonald, D. Villeneuve, M. Maynard, D.S. Palmer, M.L. Marty, C.C. Mintzer, M.J. Larrieu, M. Vispi, F. Panicucci, Kosta Savic, M. Niederberger, B. Justica, M.B. Mansour, F. Schnabel, P. Gratz, M. Inagaki, B. Evans, B. Herchenhan, G. Mariani, D. Rosenblatt, D. Poggiolini, H. Pollmann, R.E. George, T. Grobler, P.D. Meager, D.R. Urquhart, A. Yannitsiotis, T. Mandalaki, K.A. Rickard, G. Tann, J.A. Aznar, C. Louizou, A. Bellamy, K. Jain, M. McPherson, T. Ripa, E. Tackaberry, F. Mandelli, L. Miranda, T. Aguado, S. Solinas, U. Budde, W.E.S. Cavalcanti, W. Thomas, J.M. Sánchez-Cuenca, A. Voerkel, G. Marbel, C. Vermylen, G. Weissbach, P. Jones, D.R. Harkness, E. Morscher, Hans-Christoph Steinhausen, A. Burzyńska-Klubowska, H. Gadner, C. Feddersen, B. Dyszy-Laube, P. Wassef, M. Stuparu, P.M. Mannucci, D. Badia, F. Koller, J. Campbell, B. Conte, S. Andronescu-Ghika, R.B. Philp, B. Westphal, G. Lüchters, Musajo Somma, A.M. Prince, R. Cordero, D. Palmer, M.A. Smith, E. Scheibel, A.F.H. Britten, D.K. Baird, L. Lecchini, W.H. Cruickshank, N. Terekhov, M. Magallon, E. Wincott, K. Yamada, E.C.Y. Lian, G. Farrah, G. Schumpe, R. Cole, E. Beikirch, M. Campos, F. Ortega, M.J. Inwood, W. Fischer, K. Schimpf, L. Adelewitz, K.P. Schwuchow, G. Rock, Donald E. Colburn, W. Rudowski, T. Holbrook, I. Schurwanz, J.G. Richards, G.A. Marbel, N. Egberg, E. Randi, J.M. Ziemski, A.M. Afifi, Jonce Nedelkoski, T. Wahlberg, A. Scaraggi, S. Scaraggi, A. Celada, G. Syafei, and W. Stephan

Subjects
Pediatrics, medicine.medical_specialty, Hematology, business.industry, Physiology (medical), Internal medicine, medicine, Haemophilia, medicine.disease, business, Surgery
Published
1981

4. National Status Reports

Author

S. Lopaciuk, D. Villeneuve, M.B. Mansour, R.E. George, M. Blombäck, T. Rosemberg, F. Schnabel, B. Dyszy-Laube, L.M. Aledort, P. Arends, A. Testi, A.M. Sabbatini, F. Agrestini, C. Espinosa, D.A. McClure, C. Louizou, H. Gadner, L. Sjamsoedin-Visser, L. Capozzi, T. Goodwin, Martin J. Inwood, J.J. Noy, G.F. Savidge, H. Roessler, C. Louijou, H.H. Brackmann, E. Pinori, Peter H Levine, A.H. Sutor, H. Beeser, R.B. Philp, Ervin Gebauer, G. Lüchters, Ch. Beck, P. Wassef, A.M. Afifi, H. Pollmann, F. Feldmann, Aaron M. Josephson, S.G. Resnik, F. Etzel, P. Hofmann, R. Kotischke, T. Aguado, F. Koller, A. Sagripanti, A. Aronstam, G. Martin, F. Querol, E. Scheibel, M. Niederberger, Ionia McDonald, C.J. Cornell, A.F.H. Britten, W.H. Cruickshank, N. Terekhov, Theis Bacher, N. Ciavarella, A. Yannitsiotis, M. Maynard, Kosta Savic, D.R. Urquhart, A. Bellamy, T. Mandalaki, M. Campos, G. Tann, B. Evans, K. Jain, P.H. Lambert, W.E.S. Cavalcanti, W. Thomas, U. Budde, M. Kazama, D.R. Harkness, E. Morscher, D.K. Baird, D. Poggiolini, M. Stuparu, K.M. da Motta, E. Vaugh, D. Badia, C. Vermylen, K. Koch, B. Schlier, B. Justica, T. Grobler, Y. Laurian, B. Conte, F. Ortega, B. Westphal, H. Egli, Musajo Somma, E.C.Y. Lian, G. Farrah, M. Inagaki, A.M. Prince, L. Miranda, M. Magallon, N. Heimburger, J. Eibl, S. Stenbjerg, J. Martin-Villar, K.A. Rickard, C. Smit, J.A. Aznar, C. Feddersen, P.D. Meager, G. Kumpe, D. Palmer, S. Solinas, M. McPherson, T. Ripa, M.H. Maurer, G. Weissbach, E. Wincott, P. Jones, F. Mandelli, Monteiro Marhino, T. Abe, M.J. Larrieu, F. Panicucci, K. Schimpf, M.L. Marty, C.C. Mintzer, S. Andronescu-Ghika, G. Mariani, D. Rosenblatt, L. Lecchini, G. Giamarelos, K. Yamada, D.S. Palmer, L. Adelewitz, K.P. Schwuchow, G. Schumpe, R. Cole, M. Vispi, E. Beikirch, C. Bastianini, E. Tackaberry, J.M. Sánchez-Cuenca, P. Gratz, M.J. Inwood, B. Killackey, J. Barbara-Branco, N. Egberg, E. Randi, P. Tittley, K. Ackermann, M. Benali, J.M. Ziemski, Jonce Nedelkoski, G. Rock, Donald E. Colburn, W. Rudowski, T. Holbrook, A. Voerkel, G. Marbel, A. Burzyńska-Klubowska, P.M. Mannucci, J. Campbell, L. Villa, I. Schurwanz, J.G. Richards, G.A. Marbel, W. Fischer, W. Altendorf, D. Heinrich, H. Schwinn, B. Herchenhan, G. Syafei, Hans-Christoph Steinhausen, W. Stephan, R. Cordero, M.A. Smith, T. Wahlberg, A. Scaraggi, S. Scaraggi, A. Celada, M.G. Maynard, and F. Amoros

Subjects
Physiology (medical), Hematology
Published
1981

5. Contents, Vol. 10, Supplement 1, 1981

Author

A. Voerkel, G. Marbel, P. Gratz, A. Burzyńska-Klubowska, B. Herchenhan, H. Gadner, P.M. Mannucci, C.J. Cornell, E.C.Y. Lian, N. Ciavarella, S. Solinas, B. Evans, E. Scheibel, J. Campbell, G. Farrah, R.B. Philp, S. Andronescu-Ghika, G. Lüchters, M. Kazama, T. Aguado, L. Capozzi, A.F.H. Britten, D. Poggiolini, G. Rock, C. Feddersen, Hans-Christoph Steinhausen, G. Syafei, Peter H Levine, A.H. Sutor, H. Beeser, Ervin Gebauer, K. Koch, C. Bastianini, J. Martin-Villar, Martin J. Inwood, J.J. Noy, L. Sjamsoedin-Visser, A.M. Sabbatini, Donald E. Colburn, D.A. McClure, F. Etzel, F. Agrestini, A. Yannitsiotis, Aaron M. Josephson, P. Hofmann, G. Schumpe, R. Cole, L.M. Aledort, L. Adelewitz, T. Mandalaki, K.A. Rickard, R. Kotischke, E. Beikirch, W. Rudowski, A. Aronstam, A. Testi, D.K. Baird, L. Villa, B. Killackey, F. Querol, G. Tann, G. Martin, K. Jain, S.G. Resnik, H. Pollmann, J.A. Aznar, T. Ripa, K.P. Schwuchow, D.R. Urquhart, W. Stephan, A. Sagripanti, C. Smit, K.M. da Motta, Theis Bacher, W.E.S. Cavalcanti, W. Thomas, R.E. George, J. Barbara-Branco, Jonce Nedelkoski, Ionia McDonald, M.G. Maynard, Monteiro Marhino, M. Maynard, S. Stenbjerg, R. Cordero, F. Amoros, Kosta Savic, N. Egberg, M.A. Smith, A. Bellamy, P.H. Lambert, D.S. Palmer, M. Vispi, S. Lopaciuk, K. Schimpf, E. Randi, F. Schnabel, D. Villeneuve, M.B. Mansour, T. Grobler, M.L. Marty, C.C. Mintzer, T. Holbrook, T. Wahlberg, G. Mariani, D. Rosenblatt, J.M. Ziemski, J. Eibl, M. Campos, E. Pinori, H. Roessler, B. Dyszy-Laube, U. Budde, M. Magallon, A. Scaraggi, M.H. Maurer, D.R. Harkness, E. Morscher, E. Wincott, L. Miranda, M. McPherson, P. Tittley, K. Ackermann, Y. Laurian, S. Scaraggi, A. Celada, A.M. Afifi, E. Vaugh, F. Feldmann, M.J. Larrieu, F. Mandelli, H. Egli, F. Ortega, G. Weissbach, M. Benali, F. Panicucci, C. Vermylen, P. Jones, M.J. Inwood, L. Lecchini, M. Blombäck, W. Fischer, T. Rosemberg, G. Kumpe, C. Louizou, W. Altendorf, D. Badia, E. Tackaberry, K. Yamada, N. Heimburger, B. Conte, B. Westphal, J.M. Sánchez-Cuenca, C. Espinosa, I. Schurwanz, J.G. Richards, Musajo Somma, W.H. Cruickshank, D. Heinrich, N. Terekhov, G.A. Marbel, A.M. Prince, D. Palmer, H. Schwinn, M. Stuparu, P. Arends, B. Justica, Ch. Beck, M. Inagaki, T. Goodwin, G.F. Savidge, M. Niederberger, P.D. Meager, P. Wassef, F. Koller, B. Schlier, C. Louijou, H.H. Brackmann, T. Abe, and G. Giamarelos

Subjects
medicine.medical_specialty, business.industry, Physiology (medical), General surgery, Medicine, Physiology, Hematology, business
Published
1981

6. Chairmen and Participants

Author

G. Syafei, T. Abe, A.M. Afifi, W. Stephan, P.H. Lambert, N. Ciavarella, G. Giamarelos, W.H. Cruickshank, N. Terekhov, M. Magallon, E. Wincott, F. Schnabel, P. Gratz, D. Badia, B. Conte, B. Westphal, Monteiro Marhino, S.G. Resnik, Martin J. Inwood, J.J. Noy, A. Voerkel, G. Marbel, D.R. Urquhart, Musajo Somma, A.M. Prince, M. Stuparu, M.L. Marty, Ionia McDonald, M. Kazama, E.C.Y. Lian, C. Louijou, H.H. Brackmann, C.C. Mintzer, K.M. da Motta, M. Maynard, N. Egberg, E. Randi, D. Palmer, M.G. Maynard, F. Amoros, S. Lopaciuk, D. Villeneuve, J. Martin-Villar, L. Miranda, A. Burzyńska-Klubowska, J.M. Ziemski, D.K. Baird, K. Koch, M.B. Mansour, R.B. Philp, D.A. McClure, B. Schlier, P. Wassef, G. Farrah, A. Sagripanti, L. Sjamsoedin-Visser, C. Vermylen, M.J. Larrieu, F. Koller, G. Weissbach, L. Adelewitz, W. Altendorf, Theis Bacher, K.P. Schwuchow, F. Panicucci, G. Lüchters, A. Bellamy, L.M. Aledort, P. Jones, P.M. Mannucci, H. Roessler, Kosta Savic, W. Fischer, S. Stenbjerg, D. Heinrich, P. Tittley, B. Justica, U. Budde, C. Louizou, F. Feldmann, M. Inagaki, A. Yannitsiotis, R.E. George, J. Campbell, D. Poggiolini, T. Mandalaki, P.D. Meager, H. Schwinn, K. Ackermann, A.M. Sabbatini, A. Testi, H. Pollmann, D.R. Harkness, E. Morscher, H. Gadner, T. Wahlberg, F. Agrestini, C. Bastianini, G. Tann, K. Jain, Ch. Beck, G. Mariani, D. Rosenblatt, M. Benali, A. Scaraggi, J. Eibl, K.A. Rickard, J.A. Aznar, G. Schumpe, R. Cole, T. Ripa, E. Tackaberry, M. Niederberger, W.E.S. Cavalcanti, B. Dyszy-Laube, Y. Laurian, M.H. Maurer, E. Scheibel, W. Thomas, B. Killackey, S. Scaraggi, A. Celada, F. Etzel, E. Beikirch, J.M. Sánchez-Cuenca, L. Villa, A. Aronstam, G. Martin, A.F.H. Britten, P. Hofmann, R. Kotischke, E. Vaugh, H. Egli, P. Arends, F. Querol, T. Goodwin, J. Barbara-Branco, G.F. Savidge, B. Herchenhan, T. Aguado, N. Heimburger, G. Kumpe, C.J. Cornell, M. Campos, Hans-Christoph Steinhausen, R. Cordero, C. Smit, T. Grobler, M.A. Smith, E. Pinori, F. Ortega, M.J. Inwood, D.S. Palmer, M. Vispi, C. Feddersen, M. Blombäck, T. Rosemberg, M. McPherson, F. Mandelli, C. Espinosa, L. Capozzi, Peter H Levine, A.H. Sutor, H. Beeser, Ervin Gebauer, Aaron M. Josephson, I. Schurwanz, J.G. Richards, G.A. Marbel, S. Solinas, S. Andronescu-Ghika, T. Holbrook, B. Evans, G. Rock, Donald E. Colburn, W. Rudowski, Jonce Nedelkoski, K. Schimpf, L. Lecchini, and K. Yamada

Subjects
medicine.medical_specialty, business.industry, Physiology (medical), General surgery, medicine, Hematology, business, Surgery
Published
1981

7. Orthopaedics and Haemophilia

Author

S. Lopaciuk, D. Villeneuve, M.B. Mansour, A. Yannitsiotis, W. Altendorf, N. Egberg, W. Fischer, E.C.Y. Lian, T. Mandalaki, G. Tann, E. Randi, T. Holbrook, F. Schnabel, Monteiro Marhino, K.M. da Motta, D. Heinrich, L. Lecchini, K. Yamada, K. Jain, J.M. Ziemski, H. Schwinn, G. Farrah, C. Louijou, H.H. Brackmann, B. Justica, C. Louizou, W.E.S. Cavalcanti, W. Thomas, C. Smit, M.L. Marty, C.C. Mintzer, C.J. Cornell, M. Inagaki, R.E. George, S. Stenbjerg, K. Schimpf, L.M. Aledort, M. Blombäck, W.H. Cruickshank, T. Rosemberg, T. Grobler, P.D. Meager, N. Terekhov, M.J. Larrieu, G. Schumpe, R. Cole, F. Panicucci, J. Eibl, D.S. Palmer, L. Villa, H. Gadner, S. Solinas, B. Schlier, B. Dyszy-Laube, Y. Laurian, E. Beikirch, H. Egli, H. Pollmann, L. Adelewitz, M.H. Maurer, G. Mariani, D. Rosenblatt, Jonce Nedelkoski, M. Vispi, G. Syafei, M. Magallon, T. Abe, J. Martin-Villar, F. Etzel, K.P. Schwuchow, N. Ciavarella, I. Schurwanz, P. Hofmann, R. Kotischke, J.G. Richards, B. Herchenhan, P. Gratz, C. Espinosa, D.R. Urquhart, S. Andronescu-Ghika, W. Stephan, E. Wincott, G. Kumpe, M. McPherson, A.M. Sabbatini, E. Scheibel, A. Sagripanti, F. Querol, P. Wassef, F. Koller, G. Giamarelos, F. Mandelli, A.M. Afifi, M. Kazama, A.F.H. Britten, F. Agrestini, Theis Bacher, A. Voerkel, Martin J. Inwood, M. Campos, G. Rock, P. Arends, K. Koch, G. Marbel, J.J. Noy, G.A. Marbel, Hans-Christoph Steinhausen, T. Aguado, C. Feddersen, L. Sjamsoedin-Visser, C. Bastianini, E. Pinori, T. Wahlberg, A. Testi, S.G. Resnik, L. Capozzi, Donald E. Colburn, A. Burzyńska-Klubowska, P.H. Lambert, P.M. Mannucci, J. Campbell, Kosta Savic, E. Tackaberry, J.M. Sánchez-Cuenca, R.B. Philp, D.A. McClure, G. Lüchters, Ionia McDonald, H. Roessler, M. Maynard, F. Feldmann, T. Goodwin, G.F. Savidge, D. Badia, D. Poggiolini, A. Bellamy, U. Budde, A. Aronstam, G. Martin, A. Scaraggi, S. Scaraggi, A. Celada, R. Cordero, M.A. Smith, D.K. Baird, B. Killackey, J. Barbara-Branco, Peter H Levine, A.H. Sutor, H. Beeser, Ervin Gebauer, Aaron M. Josephson, F. Ortega, M.J. Inwood, P. Tittley, K. Ackermann, M. Benali, W. Rudowski, C. Vermylen, B. Evans, Ch. Beck, B. Conte, M. Stuparu, B. Westphal, D.R. Harkness, E. Morscher, M. Niederberger, L. Miranda, E. Vaugh, K.A. Rickard, J.A. Aznar, T. Ripa, Musajo Somma, N. Heimburger, G. Weissbach, A.M. Prince, P. Jones, D. Palmer, M.G. Maynard, and F. Amoros

Subjects
medicine.medical_specialty, business.industry, Physiology (medical), General surgery, Orthopedic surgery, medicine, Hematology, business, Haemophilia, medicine.disease, Surgery
Published
1981

8. Sensitivity of substituted hydroxylamines to determination by iodine oxidation

Author

T. Viswanatha, G. Tomlinson, and W.H. Cruickshank

Subjects
Chemical Phenomena, Hydrochloride, Inorganic chemistry, Biophysics, chemistry.chemical_element, Hydroxylamines, Iodine, Biochemistry, chemistry.chemical_compound, Hydroxylamine, Drug Stability, Piperidines, Oximes, Methods, Amines, Nitrite, Molecular Biology, Nitrites, Aldehydes, Alanine, Cell Biology, Hydrogen-Ion Concentration, Chemistry, Kinetics, chemistry, Evaluation Studies as Topic, Spectrophotometry, Yield (chemistry), Chromatography, Thin Layer, Oxidation-Reduction
Abstract

Several substituted hydroxylamines were used in order to assess the ability of iodine to oxidize the hydroxylamine function to nitrite. Quantitative conversion was obtained with only one of the compounds, N -methylhydroxylamine hydrochloride. The oxidation was found to be critically pH-dependent but, with the exception of N -methylhydroxyl-amine, the yield of nitrite could not be made quantitative. Some possible reasons for this have been discussed. The applicability of the method to the differential determination of N -methylhydroxylamine and free hydroxylamine has been demonstrated.

Published
1971

9. A Symposium

Author

Adrian Anglin, Paul Michael O'sullivan, Laureila McClelland, H.I. Kinsey, W.H. Cruickshank, A.C. Norwich, C.B. Graham, W. C. Kruger, P.W. Hardie, Dorothy V. Kitchen, E. L. Sexsmith, S.J. Forrest, T.G. Heaton, T. R. Welwood, Magnus Spence, William Ogden, Merle F. Bassingthwaighte, G. C. Anglin, Milton H. Brown, Horace Macintyre, and Margaret S. Thompson

Subjects
medicine.medical_specialty, Pediatrics, Tuberculosis, business.industry, Tuberculin, General Medicine, medicine.disease, Danger sign, Graph, Surgery, Rest (finance), medicine, Abnormality, business
Abstract

1) Tuberculosis contacts and nurses-in-training are tested with tuberculin every 4 months. If and when positive, they are then serologically tested every 4 months. 2) Danger signs of approaching tuberculous disease are seen when successive Inhibitive or Fixation reactions produce certain positive or significant serological graphs. A graph showing variation portends more imminent danger than if merely positive. It is explained that this is understandable with immunological reactions. Recent marked increase in tuberculin sensitivity adds to the precariousness of the situation. 3) When Danger Signs are seen in the graphs of nurses on full-day duty, we order sleep in their daily hours off, and the deletion of four of their six late leaves per month. This usually dissipates the danger, and tuberculous disease fails to develop. If however, the danger does not disappear after several months of this enforced rest, we change the prescription to one, two or three months in bed at home. With contacts on ordinary 7 or 8 houra-day work, advancing the average lights-out hour from 12 p. m. to 11 or from 11 to 10 is usually sufficient; alternate week-ends in bed, may be added. Failure in taking the rest results sooner or later in the development of tuberculosis in most of these individuals. 4) Three examples of a safe graph are shown: no danger signals, no extra rest taken, and no tuberculosis developed. Ten examples of danger warning graphs are shown, where extra rest was taken, the danger signals abated, and no disease developed. A dozen danger warning graphs are then shown where the prescribed rest was not taken, and tuberculosis did develop. 5) The two main factors in the success of the method are, firstly, precision in the interpretation of tests, and secondly, firmness in prescribing rest on a purely hypothetical basis and in the absence of symptoms or any manifest abnormality.

Published
1946

10. The presence of high and low molecular weight forms of factor VIII in heparinized plasma

Author

D.S. Palmer, Gail Rock, W.H. Cruickshank, and E.S. Tackaberry

Subjects
chemistry.chemical_classification, Blood Specimen Collection, Chromatography, Factor VIII, Heparin, Thrombin, chemistry.chemical_element, Hematology, Calcium, Gel permeation chromatography, Molecular Weight, chemistry, Sephadex, medicine, Centrifugation, Density Gradient, Chromatography, Gel, Molecule, Humans, Ultracentrifuge, Citrates, Glycoprotein, medicine.drug
Abstract

Low molecular weight Factor VIII is thought to exist either as an integral part of a high molecular weight glycoprotein or as a noncovalently linked component which is dissociated from the large parent molecule in the presence of high calcium concentrations. However, all of this previous work on the molecular structure of Factor VIII has been done using blood which was collected into an anticoagulant that acts by chelating calcium. In order to study the structure of Factor VIII under conditions where the calcium concentrations are maintained at physiological levels during the entire period of collection, blood was taken directly into heparin. This anticoagulant inhibits clot formation by inactivating thrombin but leaves the ionic composition of the plasma unaltered. Under these conditions, more than 50% of the Factor VIII activity is associated with a low molecular weight fraction. This low molecular weight fraction may be effectively separated from the high molecular weight glycoprotein by either gel chromatography or sucrose gradient ultracentrifugation. Further chromatography on a calibrated Sephadex G-100 column shows that the procoagulant molecule has a molecular weight of approximately 20,000. The data support the “two molecule” theory for the structure of Factor VIII and suggest that the many inconsistencies in the literature reflect differences in the ionic environment of the molecule.

Published
1978

11. Stability of VIII:C in plasma: the dependence on protease activity and calcium

Author

D.S. Palmer, Gail Rock, Peter R. Ganz, W.H. Cruickshank, and E.S. Tackaberry

Subjects
Male, Proteases, Isoflurophate, medicine.medical_treatment, chemistry.chemical_element, Calcium, Benzamidine, Specimen Handling, chemistry.chemical_compound, medicine, Humans, Aprotinin, Protease Inhibitors, Antigens, Chelating Agents, Protease, Factor VIII, Kunitz STI protease inhibitor, Chemistry, Heparin, Thrombin, Anticoagulants, Hematology, Benzamidines, Phenylmethylsulfonyl Fluoride, Biochemistry, Blood Preservation, Female, PMSF, medicine.drug
Abstract

Loss of Factor VIII procoagulant activity (VIII:C) following blood collection is a major problem in providing sufficient amounts for therapeutic use and biochemical analyses. We have examined the effects of inhibition of plasma proteases and maintenance of physiological calcium ion on plasma VIII:C stability. The addition of protease inhibitors such as benzamidine, phenylmethylsulfonyl fluoride (PMSF), aprotinin, or soybean trypsin inhibitor (SBTI) to CPD plasma provided no significant protection against decay of VIII:C activity. Neither the rate of decay in the first 24 hours nor the final VIII:C activity observed after storage for 48-72 hours were significantly altered. On the other hand, addition of DFP or heparin to CPD plasma resulted in a marked improvement in VIII:C stability over 24 hours. This demonstrated that these two inhibitors are effective in preventing VIII:C degradation during storage. In addition to protease inhibition, the importance of maintaining physiological calcium ion was demonstrated by 100% stabilization of VIII:C in heparin plasma. Plasma obtained from CPD plus heparin blood could also be stabilized provided free calcium ion levels were restored to physiological concentrations. The inactivation of VIII:C in CPD plus heparin plasma was completely reversible up to 4 hours after collection. Studies on the recovery of activity after recalcification of CPD plus heparin plasma provided kinetic data which support a renaturation process of VIII:C rather than one due to enzymatic activation. The use of a thrombin-specific chromogenic substrate revealed that after recalcification and during the recovery of VIII:C activity, there was no significant thrombin activity. Although the data suggest that proteolytic degradation plays some part in VIII:C decay, only the maintenance of physiologic calcium ion levels under cover of an effective non-chelating anticoagulant and protease inhibitor allows preservation of VIII:C activity.

Published
1983

12. Stabilization Of FVIII: C By Calcium

Author

E.S. Tackaberry, W.H. Cruickshank, D.S. Palmer, and Gail Rock

Subjects
medicine.medical_specialty, Endocrinology, chemistry, Internal medicine, medicine, chemistry.chemical_element, Calcium
Abstract

The well-known two phase decay curve of Factor VIII which has been attributed to enzyme degradation is not altered by the addition of specific protease inhibitors. However, complete stability of Factor VIII, for at least 24 hours, is accomplished when physiological levels of calcium are maintained. Addition of calcium plus heparin to whole blood at 0, 2, and even 4 hours, effectively restores Factor VIII activity to 0 time values and maintains this activity throughout the next 24 hours. The restoration of activity noted after 2 and 4 hours.of incubation is very rapid with the Factor VIII activity increasing within 15 minutes of addition of calcium. Data obtained from column chromatography indicates that the molecular distribution of Factor VIII between high and low molecular weight forms is affected both by time and by the level of calcium present in blood. When blood is collected either into heparin or a mixture of CPD plus heparin plus calcium chloride, the elution profile indicates that Factor VIII activity is equally distributed between high and low molecular weight forms, both at 0 and 24 hours with the total activity remaining unchanged during this time interval. However, when Factor VIII activity at 0 time is in the high molecular weight form with less than 10% in the low molecular weight form. By 24 hours there is virtually no low molecular weight activity remaining in this citrated plasma. The data demonstrate an absolute requirement for calcium in the maintenance of Factor VIII: C activity and suggests that the relative lability of Factor VIII during the first phase of the decay curve is due to the loss of VIII: C activity when calcium is not present at physiological concentrations to stabilize the molecule.

Published
1981

13. Factor VIII Is A Calcium-Binding Protein

Author

Gail Rock, E.S. Tackaberry, D.S. Palmer, and W.H. Cruickshank

Subjects
Biochemistry, Chemistry, Calcium-binding protein
Abstract

The high molecular weight complex of Factor VIII is known to dissociate into two subunits when chromatographed in a high ionic strength solution containing either calcium or sodium salts. Calcium also has an essential role in maintaining Factor VIII activity during storage (AABB 1980). These two findings suggest ah integral involvement of calcium in the basic structure-function relationship of the Factor VIII molecule. Consequently, we have examined the binding of 45Ca to both the low molecular weight (LMW) procoagulant subunit of Factor VIII and the high molecular weight (HMW) complex using PAGE and column chromatography on Sepharose 4B. When the HMW complex of Factor VIII was isolated from cryoprecipitate by standard chromatographic procedures, incubated with 45CaCl2 and subjected to polyacrylamide gel electrophoresis, the resultant autoradiogram demonstrated that all of the 45Ca was associated with the HMW material which did not enter the gel. When this HMW Factor VIII was incubated with 45Ca and then dissociated by column chromatography in a buffer containing 0.25 M CaCl2, all of the 45Ca was associated with the material eluting in the 2.3 Vo region. This corresponds to the elution volume of the LMW, procoagulant subunit of Factor VIII. Dialysis against buffer was not effective in removing the 45Ca. The data indicate that calcium is tightly associated with the low molecular weight subunit of Factor VIII and presents further corroborative evidence that calcium has an essential role in determining both the chemical and physical properties of the Factor VIII molecule.

Published
1981

14. Variant forms of procoagulant-like factor VIII in hemophiliacs

Author

Gail Rock, D.S. Palmer, and W.H. Cruickshank

Subjects
Hemophilia A, Column chromatography, Von willebrand, Animals, Chemical Precipitation, Humans, Low molecular weight protein, Polyacrylamide gel electrophoresis, Blood Coagulation, Cryoglobulins, Factor VIII, biology, Chemistry, Isoelectric focusing, food and beverages, Genetic Variation, Hematology, Molecular biology, Staining, Molecular Weight, Ionic strength, biology.protein, Chromatography, Gel, Electrophoresis, Polyacrylamide Gel, Rabbits, Antibody, Isoelectric Focusing
Abstract

Plasmas from two cross-reactive material (CRM) negative and two CRM positive hemophiliacs are shown to contain a biologically inactive procoagulant-like protein which is analogous to the low molecular weight active protein dissociated from the Factor VIII of normal individuals at high ionic strength. This low molecular weight protein (LMW) from the hemophiliacs elutes from column chromatography with a pattern similar to the normal. However, following polyacrylamide gel electrophoresis (PAGE) or isoelectric focusing (IEF), the protein bands, as demonstrated by Coomassie staining of reaction with antibody, show a striking picture of heterogeneity. Further biochemical characterization and comparison with LMW from normal individuals indicates that the hemophilic LMW protein has a wide variation in carbohydrate content ranging from approximately 12%, as is the case with the normal, to 39.5%. The data suggests that, like von Willebrand's disease, hemophilia may exist in variant forms with alteration in carbohydrate content responsible for differences in reactivity with antibody and possibly for lack of procoagulant activity.

Published
1981

15. Questions and Answers – Workshop on Comprehensive Care (Workshop I)

Author

L. Lecchini, S.G. Resnik, D.K. Baird, Ionia McDonald, M. Maynard, M. Blombäck, T. Rosemberg, K. Yamada, A.M. Sabbatini, F. Agrestini, W.H. Cruickshank, N. Terekhov, M. Magallon, E. Wincott, D.R. Urquhart, C. Louijou, H.H. Brackmann, C.J. Cornell, R. Cordero, C. Espinosa, M.G. Maynard, F. Amoros, M.A. Smith, M.J. Inwood, S. Solinas, L. Villa, S. Lopaciuk, D. Villeneuve, L. Capozzi, M.B. Mansour, L. Adelewitz, Y. Laurian, B. Herchenhan, A. Yannitsiotis, K.P. Schwuchow, I. Schurwanz, C. Bastianini, J.G. Richards, Peter H Levine, A.H. Sutor, H. Beeser, C. Vermylen, Ervin Gebauer, T. Holbrook, T. Mandalaki, A. Sagripanti, G. Tann, Martin J. Inwood, J.J. Noy, H. Egli, B. Killackey, S. Andronescu-Ghika, Hans-Christoph Steinhausen, Aaron M. Josephson, K. Jain, E.C.Y. Lian, A. Voerkel, R.B. Philp, L. Miranda, G. Kumpe, Theis Bacher, G. Marbel, G. Farrah, W.E.S. Cavalcanti, W. Thomas, W. Altendorf, E. Vaugh, T. Abe, J. Barbara-Branco, N. Egberg, G. Lüchters, A. Burzyńska-Klubowska, G. Weissbach, F. Schnabel, E. Randi, D. Heinrich, P. Jones, Kosta Savic, C. Smit, H. Schwinn, J.M. Ziemski, G. Schumpe, R. Cole, K. Schimpf, A. Testi, P.M. Mannucci, E. Beikirch, E. Pinori, G. Syafei, F. Etzel, P. Hofmann, R. Kotischke, D.S. Palmer, J. Campbell, Ch. Beck, G.A. Marbel, L. Sjamsoedin-Visser, F. Querol, E. Tackaberry, M. Vispi, A.M. Afifi, M. Niederberger, G. Giamarelos, B. Schlier, T. Aguado, M. Campos, T. Grobler, J.M. Sánchez-Cuenca, B. Evans, P. Tittley, K. Ackermann, G. Rock, M. Benali, F. Ortega, K.M. da Motta, R.E. George, M. McPherson, Donald E. Colburn, J. Martin-Villar, J. Eibl, W. Rudowski, F. Mandelli, P. Gratz, S. Stenbjerg, M.H. Maurer, W. Stephan, B. Dyszy-Laube, G. Mariani, D. Rosenblatt, Jonce Nedelkoski, W. Fischer, P.H. Lambert, N. Heimburger, N. Ciavarella, M. Kazama, H. Gadner, A. Aronstam, T. Wahlberg, A. Scaraggi, G. Martin, S. Scaraggi, A. Celada, K. Koch, L.M. Aledort, Monteiro Marhino, H. Pollmann, D. Badia, B. Conte, M.L. Marty, C.C. Mintzer, B. Westphal, Musajo Somma, A.M. Prince, D. Palmer, A. Bellamy, C. Feddersen, C. Louizou, U. Budde, P. Wassef, F. Koller, D.R. Harkness, E. Morscher, E. Scheibel, A.F.H. Britten, D.A. McClure, B. Justica, H. Roessler, M. Inagaki, F. Feldmann, P.D. Meager, M. Stuparu, P. Arends, T. Goodwin, G.F. Savidge, D. Poggiolini, K.A. Rickard, J.A. Aznar, T. Ripa, M.J. Larrieu, and F. Panicucci

Subjects
Questions and answers, medicine.medical_specialty, Medical education, business.industry, Physiology (medical), Alternative medicine, medicine, Physiology, Hematology, business
Published
1981

16. National Status Reports (Poster Presentation)

Author

A. Sagripanti, Theis Bacher, Kosta Savic, B. Justica, C. Smit, M. Inagaki, P.D. Meager, D.S. Palmer, M. Stuparu, M. Vispi, A. Yannitsiotis, W. Altendorf, T. Mandalaki, D. Heinrich, T. Holbrook, G. Tann, H. Schwinn, K. Jain, P. Gratz, W.E.S. Cavalcanti, W. Thomas, M. Blombäck, A.M. Afifi, T. Rosemberg, E. Scheibel, C. Espinosa, R.E. George, A.F.H. Britten, L. Capozzi, M. Campos, A.M. Sabbatini, F. Agrestini, B. Schlier, B. Herchenhan, E. Pinori, A. Testi, D. Badia, B. Conte, F. Ortega, I. Schurwanz, J.G. Richards, P. Tittley, B. Dyszy-Laube, K. Ackermann, E.C.Y. Lian, D. Poggiolini, Peter H Levine, A.H. Sutor, G. Farrah, B. Westphal, Musajo Somma, G. Rock, L. Villa, Martin J. Inwood, J.J. Noy, M. Benali, A.M. Prince, N. Ciavarella, G. Schumpe, R. Cole, H. Beeser, Ervin Gebauer, T. Aguado, E. Beikirch, Hans-Christoph Steinhausen, D. Palmer, Aaron M. Josephson, C. Louizou, D.A. McClure, R.B. Philp, G.A. Marbel, G. Syafei, C.J. Cornell, G. Lüchters, Donald E. Colburn, W. Rudowski, F. Etzel, P. Hofmann, N. Egberg, R. Kotischke, P. Wassef, K.M. da Motta, F. Koller, E. Randi, M. Kazama, F. Querol, R. Cordero, Jonce Nedelkoski, H. Roessler, A. Voerkel, G. Marbel, M.J. Inwood, J.M. Ziemski, M.A. Smith, W. Stephan, K.A. Rickard, J. Eibl, K. Koch, Ch. Beck, W. Fischer, B. Evans, A. Burzyńska-Klubowska, M.H. Maurer, S. Stenbjerg, F. Feldmann, J.A. Aznar, T. Ripa, L.M. Aledort, M. Niederberger, P.M. Mannucci, G. Mariani, D. Rosenblatt, S. Solinas, J. Campbell, L. Miranda, L. Adelewitz, K.P. Schwuchow, G. Weissbach, P. Jones, C. Feddersen, D.R. Urquhart, S. Andronescu-Ghika, P. Arends, Monteiro Marhino, T. Wahlberg, T. Goodwin, A. Scaraggi, H. Pollmann, G.F. Savidge, S. Scaraggi, A. Celada, M.L. Marty, C.C. Mintzer, L. Sjamsoedin-Visser, M.J. Larrieu, C. Vermylen, F. Panicucci, A. Aronstam, G. Martin, T. Grobler, T. Abe, M. McPherson, F. Mandelli, W.H. Cruickshank, N. Terekhov, M. Magallon, E. Wincott, G. Giamarelos, D.K. Baird, C. Louijou, H.H. Brackmann, E. Vaugh, N. Heimburger, J. Martin-Villar, A. Bellamy, U. Budde, D.R. Harkness, E. Morscher, H. Gadner, L. Lecchini, E. Tackaberry, K. Yamada, J.M. Sánchez-Cuenca, M.G. Maynard, F. Amoros, S. Lopaciuk, D. Villeneuve, M.B. Mansour, Y. Laurian, H. Egli, P.H. Lambert, G. Kumpe, S.G. Resnik, Ionia McDonald, M. Maynard, K. Schimpf, C. Bastianini, B. Killackey, J. Barbara-Branco, and F. Schnabel

Subjects
medicine.medical_specialty, Presentation, business.industry, Physiology (medical), General surgery, media_common.quotation_subject, Medicine, Hematology, business, Surgery, media_common
Published
1981

17. Pre-Conference Statements: Egli, H.: The Bonn Conference

Author

S.G. Resnik, D. Poggiolini, Ionia McDonald, K.A. Rickard, M. Maynard, J.A. Aznar, T. Ripa, K.M. da Motta, E. Tackaberry, L. Villa, J.M. Sánchez-Cuenca, M.J. Larrieu, F. Panicucci, P. Tittley, K. Ackermann, P. Arends, T. Goodwin, G.F. Savidge, S. Stenbjerg, S. Solinas, M. Benali, M. Campos, M.G. Maynard, F. Amoros, S. Lopaciuk, D. Villeneuve, F. Etzel, P. Hofmann, J. Martin-Villar, C. Bastianini, A.M. Afifi, M.B. Mansour, R. Kotischke, W.H. Cruickshank, N. Terekhov, G. Rock, G. Syafei, Monteiro Marhino, A. Voerkel, G. Marbel, G. Mariani, D. Rosenblatt, C.J. Cornell, N. Ciavarella, Donald E. Colburn, B. Killackey, F. Ortega, F. Querol, M.J. Inwood, Martin J. Inwood, C. Smit, J. Barbara-Branco, F. Schnabel, Y. Laurian, W. Fischer, A. Burzyńska-Klubowska, P.M. Mannucci, R. Cordero, W. Rudowski, J.J. Noy, H. Egli, P. Wassef, S. Andronescu-Ghika, M.A. Smith, M.L. Marty, J. Campbell, C.C. Mintzer, L. Capozzi, Peter H Levine, A.H. Sutor, D.S. Palmer, E. Pinori, P.H. Lambert, A.M. Sabbatini, F. Agrestini, F. Koller, A. Sagripanti, M. Vispi, R.E. George, T. Aguado, D.K. Baird, Jonce Nedelkoski, H. Beeser, Ervin Gebauer, N. Egberg, P. Gratz, G. Kumpe, Theis Bacher, W. Altendorf, K. Schimpf, E. Randi, D. Heinrich, H. Schwinn, Kosta Savic, J.M. Ziemski, M. Kazama, W. Stephan, I. Schurwanz, J.G. Richards, Aaron M. Josephson, E.C.Y. Lian, T. Holbrook, G. Farrah, B. Herchenhan, B. Dyszy-Laube, L. Lecchini, G.A. Marbel, M. Magallon, A. Yannitsiotis, E. Wincott, T. Mandalaki, Hans-Christoph Steinhausen, G. Schumpe, R. Cole, A. Testi, K. Koch, J. Eibl, K. Yamada, L. Adelewitz, G. Tann, E. Beikirch, C. Feddersen, L. Sjamsoedin-Visser, R.B. Philp, K.P. Schwuchow, K. Jain, M.H. Maurer, G. Lüchters, W.E.S. Cavalcanti, W. Thomas, B. Schlier, B. Justica, L.M. Aledort, M. Blombäck, T. Rosemberg, B. Evans, M. Inagaki, M. McPherson, C. Espinosa, A. Aronstam, G. Martin, F. Mandelli, P.D. Meager, H. Pollmann, T. Wahlberg, A. Scaraggi, T. Grobler, S. Scaraggi, A. Celada, T. Abe, G. Giamarelos, C. Louijou, H.H. Brackmann, D.R. Urquhart, C. Vermylen, C. Louizou, Ch. Beck, M. Niederberger, L. Miranda, G. Weissbach, A. Bellamy, E. Scheibel, P. Jones, U. Budde, D.R. Harkness, E. Morscher, A.F.H. Britten, E. Vaugh, N. Heimburger, H. Gadner, M. Stuparu, D.A. McClure, H. Roessler, F. Feldmann, D. Badia, B. Conte, B. Westphal, Musajo Somma, A.M. Prince, and D. Palmer

Subjects
business.industry, Physiology (medical), Medicine, Library science, Physiology, Hematology, business
Published
1981

18. Pre-Conference Statements: Maurer, M.H.: First International Haemophilia Conference

Author

C. Louijou, H.H. Brackmann, M.J. Larrieu, F. Panicucci, E. Vaugh, C.J. Cornell, T. Holbrook, L. Villa, D.K. Baird, N. Egberg, L.M. Aledort, L. Lecchini, N. Heimburger, A. Testi, S.G. Resnik, E. Randi, T. Abe, T. Grobler, R. Cordero, M.A. Smith, J.M. Ziemski, B. Schlier, A. Sagripanti, K. Yamada, E. Scheibel, D.R. Urquhart, Ionia McDonald, D.A. McClure, K. Schimpf, P. Arends, M. Maynard, A.F.H. Britten, Theis Bacher, T. Goodwin, G.F. Savidge, C. Vermylen, G. Giamarelos, H. Roessler, A.M. Afifi, L. Miranda, Kosta Savic, P. Tittley, K. Ackermann, W. Altendorf, F. Feldmann, A. Voerkel, G. Marbel, G. Weissbach, D. Heinrich, H. Schwinn, P. Jones, H. Pollmann, A. Bellamy, A. Burzyńska-Klubowska, A. Yannitsiotis, M. Benali, D. Poggiolini, W.H. Cruickshank, N. Terekhov, Ch. Beck, P.H. Lambert, U. Budde, C. Feddersen, D. Badia, R.B. Philp, P.M. Mannucci, T. Mandalaki, J. Campbell, T. Aguado, I. Schurwanz, M. Niederberger, D.R. Harkness, E. Morscher, H. Gadner, B. Conte, B. Westphal, G. Tann, K. Jain, M. McPherson, J.G. Richards, Musajo Somma, G. Lüchters, B. Herchenhan, K.A. Rickard, J.A. Aznar, T. Ripa, Monteiro Marhino, T. Wahlberg, M. Magallon, A.M. Prince, C. Bastianini, A. Scaraggi, Y. Laurian, P. Wassef, W.E.S. Cavalcanti, F. Koller, D. Palmer, N. Ciavarella, W. Thomas, F. Etzel, F. Mandelli, C. Smit, P. Hofmann, C. Louizou, H. Egli, K.M. da Motta, E. Wincott, G.A. Marbel, R. Kotischke, Hans-Christoph Steinhausen, B. Evans, B. Killackey, G. Kumpe, D.S. Palmer, S. Scaraggi, A. Celada, L. Adelewitz, K.P. Schwuchow, F. Querol, M. Vispi, S. Stenbjerg, M. Kazama, W. Fischer, J. Barbara-Branco, M.L. Marty, C.C. Mintzer, B. Justica, J. Martin-Villar, E. Pinori, P. Gratz, S. Solinas, F. Schnabel, K. Koch, M. Inagaki, P.D. Meager, G. Mariani, D. Rosenblatt, L. Capozzi, M. Blombäck, T. Rosemberg, Peter H Levine, A.H. Sutor, H. Beeser, R.E. George, M. Stuparu, C. Espinosa, Ervin Gebauer, Martin J. Inwood, Aaron M. Josephson, J.J. Noy, S. Andronescu-Ghika, A.M. Sabbatini, B. Dyszy-Laube, L. Sjamsoedin-Visser, G. Syafei, F. Agrestini, W. Stephan, M. Campos, J. Eibl, A. Aronstam, G. Martin, M.H. Maurer, E. Tackaberry, J.M. Sánchez-Cuenca, M.G. Maynard, F. Amoros, F. Ortega, S. Lopaciuk, D. Villeneuve, M.B. Mansour, E.C.Y. Lian, G. Farrah, G. Schumpe, R. Cole, E. Beikirch, M.J. Inwood, G. Rock, Donald E. Colburn, W. Rudowski, and Jonce Nedelkoski

Subjects
medicine.medical_specialty, Pediatrics, business.industry, Physiology (medical), Family medicine, medicine, Hematology, business, Haemophilia, medicine.disease
Published
1981

20. Questions and Answers (Workshop III)

Author

G. Rock, L.M. Aledort, L. Capozzi, Donald E. Colburn, L. Miranda, R. Cordero, E. Vaugh, D.A. McClure, W. Rudowski, M.A. Smith, Peter H Levine, A.H. Sutor, H. Beeser, G. Weissbach, D.K. Baird, R.E. George, P. Jones, Ervin Gebauer, M. Blombäck, T. Rosemberg, T. Holbrook, H. Pollmann, A. Voerkel, G. Marbel, E. Tackaberry, G. Syafei, M. Campos, Aaron M. Josephson, B. Herchenhan, I. Schurwanz, A. Testi, A. Burzyńska-Klubowska, J.M. Sánchez-Cuenca, J.G. Richards, K.M. da Motta, C. Espinosa, N. Heimburger, N. Ciavarella, F. Ortega, J. Martin-Villar, Hans-Christoph Steinhausen, B. Dyszy-Laube, E.C.Y. Lian, W. Stephan, L. Lecchini, C. Feddersen, P.M. Mannucci, G.A. Marbel, T. Abe, J. Campbell, A.M. Sabbatini, G. Farrah, F. Agrestini, H. Gadner, D.R. Urquhart, A. Yannitsiotis, M. Kazama, W. Altendorf, H. Roessler, S. Stenbjerg, T. Mandalaki, F. Schnabel, M.G. Maynard, F. Amoros, D. Heinrich, B. Schlier, H. Schwinn, Monteiro Marhino, G. Tann, W. Fischer, S. Lopaciuk, D. Villeneuve, Jonce Nedelkoski, K. Jain, F. Feldmann, M.B. Mansour, K. Yamada, K. Koch, B. Evans, R.B. Philp, G. Schumpe, R. Cole, P. Arends, E. Beikirch, C.J. Cornell, W.E.S. Cavalcanti, W. Thomas, M. McPherson, G. Lüchters, C. Vermylen, M.L. Marty, C.C. Mintzer, J. Eibl, P.H. Lambert, F. Mandelli, G. Mariani, D. Rosenblatt, T. Wahlberg, A. Scaraggi, M.H. Maurer, S. Solinas, T. Goodwin, F. Etzel, P. Hofmann, R. Kotischke, L. Villa, L. Sjamsoedin-Visser, D. Badia, G.F. Savidge, Martin J. Inwood, M.J. Inwood, A. Bellamy, S. Scaraggi, A. Celada, J.J. Noy, G. Giamarelos, B. Conte, B. Westphal, Musajo Somma, F. Querol, S. Andronescu-Ghika, U. Budde, A. Aronstam, G. Martin, Ch. Beck, C. Bastianini, A.M. Prince, D.R. Harkness, E. Morscher, K. Schimpf, T. Grobler, D. Palmer, M. Niederberger, E. Pinori, B. Killackey, T. Aguado, J. Barbara-Branco, P. Wassef, M.J. Larrieu, F. Panicucci, F. Koller, C. Louijou, H.H. Brackmann, D. Poggiolini, K.A. Rickard, J.A. Aznar, T. Ripa, P. Gratz, B. Justica, C. Smit, M. Inagaki, D.S. Palmer, M. Vispi, P.D. Meager, P. Tittley, K. Ackermann, M. Benali, W.H. Cruickshank, N. Terekhov, M. Magallon, E. Wincott, M. Stuparu, S.G. Resnik, Ionia McDonald, M. Maynard, E. Scheibel, A.F.H. Britten, Y. Laurian, H. Egli, A. Sagripanti, G. Kumpe, Theis Bacher, N. Egberg, Kosta Savic, C. Louizou, E. Randi, J.M. Ziemski, A.M. Afifi, L. Adelewitz, and K.P. Schwuchow

Subjects
Questions and answers, Medical education, business.industry, Physiology (medical), Medicine, Physiology, Hematology, business
Published
1981

21. Pre-Conference Statements: Inwood; M.J.: The Haemophiliacs Blueprint of the Eighties

Author

F. Schnabel, M.G. Maynard, S.G. Resnik, A.M. Afifi, G. Rock, Ionia McDonald, F. Amoros, S. Lopaciuk, D. Villeneuve, M.B. Mansour, M. Maynard, Donald E. Colburn, R.E. George, I. Schurwanz, J.G. Richards, W. Rudowski, H. Gadner, A. Sagripanti, E.C.Y. Lian, G. Farrah, A.M. Sabbatini, F. Agrestini, B. Herchenhan, E. Pinori, L.M. Aledort, G.A. Marbel, T. Holbrook, Theis Bacher, G. Schumpe, R. Cole, T. Grobler, E. Beikirch, B. Evans, L. Capozzi, A. Voerkel, G. Marbel, S. Solinas, Hans-Christoph Steinhausen, B. Dyszy-Laube, E. Scheibel, A. Burzyńska-Klubowska, Peter H Levine, M.J. Inwood, S. Andronescu-Ghika, A.H. Sutor, A.F.H. Britten, F. Etzel, P. Hofmann, R. Kotischke, F. Querol, H. Beeser, Ervin Gebauer, P.M. Mannucci, J. Martin-Villar, P. Gratz, J. Campbell, B. Schlier, Ch. Beck, Aaron M. Josephson, A. Bellamy, W. Altendorf, W. Fischer, M. Campos, M. Niederberger, U. Budde, H. Pollmann, D. Heinrich, N. Egberg, D.R. Harkness, E. Morscher, H. Schwinn, L. Miranda, F. Ortega, L. Lecchini, C. Bastianini, E. Randi, B. Killackey, L. Villa, J.M. Ziemski, E. Vaugh, K. Yamada, J. Barbara-Branco, G. Weissbach, B. Justica, P. Jones, M. Inagaki, P.D. Meager, Kosta Savic, R.B. Philp, L. Adelewitz, G. Lüchters, K.P. Schwuchow, D.R. Urquhart, D. Poggiolini, R. Cordero, C. Vermylen, C. Feddersen, C. Smit, M.A. Smith, N. Ciavarella, M. Stuparu, D.S. Palmer, P. Wassef, M. Vispi, C.J. Cornell, A. Yannitsiotis, C. Louizou, M. Kazama, M. McPherson, P. Tittley, K. Ackermann, T. Mandalaki, K. Koch, F. Mandelli, M. Benali, F. Koller, G. Tann, A. Testi, K. Jain, Jonce Nedelkoski, K.A. Rickard, E. Tackaberry, W.E.S. Cavalcanti, W. Thomas, J.A. Aznar, Y. Laurian, T. Ripa, H. Egli, Monteiro Marhino, J.M. Sánchez-Cuenca, G. Kumpe, P. Arends, M.L. Marty, C.C. Mintzer, T. Goodwin, G.F. Savidge, L. Sjamsoedin-Visser, M. Blombäck, T. Rosemberg, P.H. Lambert, A. Aronstam, G. Martin, M.J. Larrieu, F. Panicucci, C. Espinosa, K. Schimpf, M. Magallon, E. Wincott, D.A. McClure, H. Roessler, F. Feldmann, N. Heimburger, T. Abe, G. Syafei, G. Giamarelos, C. Louijou, H.H. Brackmann, W.H. Cruickshank, N. Terekhov, D. Badia, B. Conte, W. Stephan, B. Westphal, Musajo Somma, A.M. Prince, D. Palmer, T. Wahlberg, A. Scaraggi, T. Aguado, J. Eibl, M.H. Maurer, S. Scaraggi, A. Celada, Martin J. Inwood, J.J. Noy, D.K. Baird, K.M. da Motta, S. Stenbjerg, G. Mariani, and D. Rosenblatt

Subjects
medicine.medical_specialty, business.industry, Blueprint, Physiology (medical), Library science, Medicine, Hematology, business, Surgery
Published
1981

22. Questions and Answers – Workshop on Mobilizing Support for Haemophilia Care (Workshop II)

Author

Y. Laurian, H. Egli, G. Kumpe, T. Holbrook, A.M. Afifi, S.G. Resnik, Ionia McDonald, M. Maynard, T. Abe, M.J. Inwood, N. Egberg, E. Randi, J.M. Ziemski, M. Campos, K.M. da Motta, L. Adelewitz, K.P. Schwuchow, F. Ortega, S. Stenbjerg, A. Yannitsiotis, E.C.Y. Lian, G. Farrah, T. Mandalaki, G. Tann, K. Jain, G. Giamarelos, L.M. Aledort, G. Schumpe, R. Cole, W.E.S. Cavalcanti, W. Thomas, B. Herchenhan, G. Mariani, D. Rosenblatt, E. Beikirch, H. Pollmann, Jonce Nedelkoski, N. Ciavarella, W.H. Cruickshank, N. Terekhov, E. Pinori, M. Kazama, M. Blombäck, Hans-Christoph Steinhausen, T. Rosemberg, K. Koch, C. Espinosa, C. Louijou, H.H. Brackmann, D.K. Baird, B. Schlier, R. Cordero, J. Eibl, M.A. Smith, Ch. Beck, T. Aguado, L. Miranda, M.H. Maurer, M. Niederberger, G. Rock, M. Magallon, G. Weissbach, W. Fischer, P. Jones, W. Altendorf, D. Heinrich, Martin J. Inwood, H. Schwinn, J.J. Noy, E. Wincott, L. Villa, Donald E. Colburn, S. Solinas, C.J. Cornell, D.R. Urquhart, W. Rudowski, I. Schurwanz, R.B. Philp, H. Gadner, J.G. Richards, G. Lüchters, S. Andronescu-Ghika, F. Etzel, P. Hofmann, R. Kotischke, G.A. Marbel, C. Vermylen, D. Badia, P. Tittley, K. Ackermann, A. Testi, F. Querol, M. Benali, E. Vaugh, B. Conte, B. Westphal, Musajo Somma, P. Gratz, K. Schimpf, R.E. George, A. Voerkel, G. Marbel, A.M. Prince, T. Grobler, B. Evans, B. Dyszy-Laube, A. Burzyńska-Klubowska, N. Heimburger, D. Palmer, M. McPherson, D.A. McClure, P.M. Mannucci, F. Mandelli, A. Sagripanti, J. Campbell, Theis Bacher, L. Lecchini, A. Bellamy, L. Capozzi, Kosta Savic, Peter H Levine, A.H. Sutor, H. Beeser, Ervin Gebauer, U. Budde, H. Roessler, Aaron M. Josephson, D.R. Harkness, E. Morscher, K. Yamada, C. Smit, F. Feldmann, D.S. Palmer, M. Vispi, J. Martin-Villar, E. Tackaberry, J.M. Sánchez-Cuenca, P.H. Lambert, F. Schnabel, C. Bastianini, B. Killackey, J. Barbara-Branco, C. Feddersen, Monteiro Marhino, M.L. Marty, C.C. Mintzer, L. Sjamsoedin-Visser, A. Aronstam, G. Martin, P. Wassef, F. Koller, B. Justica, M. Inagaki, P.D. Meager, D. Poggiolini, K.A. Rickard, E. Scheibel, J.A. Aznar, T. Ripa, M.J. Larrieu, A.F.H. Britten, F. Panicucci, P. Arends, T. Goodwin, G.F. Savidge, C. Louizou, M. Stuparu, M.G. Maynard, F. Amoros, S. Lopaciuk, D. Villeneuve, M.B. Mansour, A.M. Sabbatini, F. Agrestini, G. Syafei, W. Stephan, T. Wahlberg, A. Scaraggi, S. Scaraggi, and A. Celada

Subjects
Questions and answers, Medical education, medicine.medical_specialty, business.industry, Physiology (medical), Alternative medicine, Medicine, Physiology, Hematology, business, Haemophilia, medicine.disease
Published
1981

23. Offices of the Conference

Author

S.G. Resnik, J. Martin-Villar, M. Campos, Ionia McDonald, F. Ortega, L.M. Aledort, N. Egberg, M. Maynard, L. Lecchini, B. Schlier, Monteiro Marhino, M.J. Inwood, E. Randi, L. Miranda, E. Vaugh, G. Weissbach, P. Jones, J.M. Ziemski, M.L. Marty, K. Yamada, C. Bastianini, M.G. Maynard, F. Amoros, R.E. George, G. Syafei, C.C. Mintzer, D.A. McClure, L. Villa, M. Magallon, M.J. Larrieu, B. Killackey, H. Pollmann, F. Panicucci, S. Lopaciuk, N. Heimburger, D.R. Urquhart, D. Villeneuve, E. Wincott, C. Louijou, H.H. Brackmann, S. Solinas, T. Grobler, P.H. Lambert, J. Barbara-Branco, Y. Laurian, B. Dyszy-Laube, M.B. Mansour, L. Adelewitz, K.P. Schwuchow, L. Sjamsoedin-Visser, N. Ciavarella, E.C.Y. Lian, H. Egli, A. Bellamy, G. Farrah, F. Etzel, A. Sagripanti, P. Hofmann, F. Schnabel, W. Stephan, R. Kotischke, D. Poggiolini, L. Capozzi, K. Schimpf, U. Budde, S. Andronescu-Ghika, A. Voerkel, C. Vermylen, Theis Bacher, A.M. Afifi, G. Marbel, F. Querol, H. Roessler, Peter H Levine, A.H. Sutor, H. Beeser, A. Aronstam, G. Martin, M. Kazama, Ervin Gebauer, D.R. Harkness, E. Morscher, G. Kumpe, H. Gadner, G. Schumpe, R. Cole, A. Burzyńska-Klubowska, Aaron M. Josephson, K.A. Rickard, K. Koch, J.A. Aznar, T. Ripa, E. Beikirch, Kosta Savic, F. Feldmann, E. Tackaberry, P.M. Mannucci, A.M. Sabbatini, C. Louizou, J.M. Sánchez-Cuenca, J. Campbell, T. Wahlberg, P. Arends, D. Badia, F. Agrestini, A. Scaraggi, B. Conte, W.H. Cruickshank, N. Terekhov, R.B. Philp, M. McPherson, T. Goodwin, G.F. Savidge, F. Mandelli, G. Lüchters, B. Westphal, S. Scaraggi, A. Celada, Ch. Beck, B. Evans, Musajo Somma, C. Feddersen, T. Abe, A.M. Prince, M. Niederberger, M. Stuparu, D.K. Baird, G. Giamarelos, D. Palmer, P. Wassef, E. Scheibel, F. Koller, A.F.H. Britten, B. Justica, M. Inagaki, P.D. Meager, M. Blombäck, T. Rosemberg, C. Espinosa, E. Pinori, K.M. da Motta, C.J. Cornell, Jonce Nedelkoski, A. Testi, S. Stenbjerg, A. Yannitsiotis, T. Mandalaki, G. Tann, I. Schurwanz, K. Jain, J.G. Richards, G. Mariani, D. Rosenblatt, W.E.S. Cavalcanti, G. Rock, W. Thomas, T. Aguado, Donald E. Colburn, G.A. Marbel, W. Rudowski, T. Holbrook, W. Fischer, P. Tittley, K. Ackermann, M. Benali, Martin J. Inwood, J.J. Noy, W. Altendorf, C. Smit, D. Heinrich, J. Eibl, M.H. Maurer, H. Schwinn, D.S. Palmer, M. Vispi, P. Gratz, R. Cordero, M.A. Smith, B. Herchenhan, and Hans-Christoph Steinhausen

Subjects
medicine.medical_specialty, business.industry, Physiology (medical), General surgery, medicine, Hematology, business, Surgery
Published
1981

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