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4 results on '"W.A. De Backer"'

1. Optimization of Adeno-Associated Viral Vector-Mediated Gene Delivery to the Hypothalamus.

Author

Marijke W.A. de Backer, Maike A.D. Brans, Mieneke C. Luijendijk, Keith M. Garner, and Roger A.H. Adan

Subjects
*ADENOVIRUSES, *GENE therapy, *HYPOTHALAMUS, *LABORATORY rats, *INGESTION, *BODY weight
Abstract

In order to efficiently target the rat hypothalamus, AAV serotypes 1, 2, and 8 and mosaic particles thereof were evaluated following stereotactical injection. Subsequent studies validated the lead candidate AAV1 in a functional model in which AAV1 mediated overexpression of the Agouti-related protein in the hypothalamus resulted in increased food intake and body weight. [ABSTRACT FROM AUTHOR]

Published
2010
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2. Use of ICAM-1 antibodies and antisense oligonucleotides to inhibit transmigration of neutrophils.

Author

A.M. Sadowska, F.J. van Overveld, C. Luyten, P. Germonpré, and W.A. De Backer

Abstract

Objective:The increase in adhesion molecule expression during the initial phase of inflammation leads to transmigration of neutrophils. Inhibition of this transmigration could decrease inflammatory response and tissue damage. Materials and methods:Uptake of fluorescein-labelled oligonucleotides, expression of ICAM-1 and neutrophil migration were studied using the bilayer of epithelial (H292) and endothelial (ECV-304) cell lines and neutrophils from peripheral blood of healthy volunteers. Results:The inhibition of ICAM-1 expression was time dependent for both cell lines, with inhibition of more than 50% after 48 h. Antisense oligos inhibited transmigration already after 4 h of incubation (6.6 ± 2.5% versus 18.6 ± 2.5% inhibition, p < 0.01). Antisense was more effective in preventing fMLP-induced neutrophil migration than ICAM-1 antibodies (88 ± 3.8% versus 67 ± 7% inhibition, p = 0.02). Conclusions:Antisense oligos cause a decrease in ICAM-1 expression and inhibit transmigration of neutrophils. However the effectiveness of antisense is higher than monoclonal antibodies, neither of them is able to block the migration completely. This suggests the existence of ICAM-1 independent mechanisms that are responsible for migration. [ABSTRACT FROM AUTHOR]

Published
2004

3. Contents, Vol. 43, 1986

Author

Hiroshi Tsuruda, M. Granowska, T. Horne, Ursula Rother, Noriyuki Nawa, C.C. Nimmon, W. Bosaller, Jürgen Bommer, Keiko Yamamoto, Eishin Yaoita, Yasuhide Mizutani, M.M. Stevenson, A. Pauls, Fujio Shimizu, Wataru Mitsuoka, Masato Seki, A.W. Asscher, L. Verresen, Hiroyuki Ohi, Stefano Bombardieri, M.R. Lee, S.R. Holdsworth, J. Madrenas, L Moriconi, M.V. García-Lucena, Eberhard Ritz, Michinobu Hatano, J.A.B. Keogh, Giuseppe Gremignai, B. Gallimore, J.A. Rodríguez, Michael Kirschfink, S. Codina, Katsutoshi Kawasaki, J.B. Young, R. Hirschberg, K.-U. Eckardt, Pier Vittorio Fosella, H. Eckardt, M. E. De Broe, J. Saupe, R.L. Lins, Clodoveo Ferri, K.E. Britton, A.M. Brownjohn, Max Notohamiprodjo, Itaru Kihara, Kaoru Onoyama, G. Paleologo, D. von Herrath, E. Mlodkowska, W.A. De Backer, Nobuaki Ohchi, Jose Strauss, K. Schaefer, Konrad Andrassy, Gaston Zilleruelo, Fumio Nanishi, Masatoshi Fujishima, Chen H. Hsu, R.F. Gagnon, Allan Juhl, Theodore W. Kurtz, W. Höfer, Tetsuro Ikezawa, Paola Migliorini, E. Ferrer, M. Carroll, Shizuhiko Watanabe, P.G. Tipping, Kazuo Kobayashi, Yukinori Oh, M.K. Nawaz, Mj. Harber, E.F. Gaffney, L. Piera, Carolyn Abitbol, J. Monné, and Tadashi Yamamoto

Subjects
Traditional medicine, business.industry, Medicine, business
Published
1986
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4. Subject Index, Vol. 43, 1986

Author

Konrad Andrassy, P.G. Tipping, M.K. Nawaz, L Moriconi, A. Pauls, Kazuo Kobayashi, M. Granowska, Yukinori Oh, Fumio Nanishi, Tadashi Yamamoto, H. Eckardt, C.C. Nimmon, Allan Juhl, M.M. Stevenson, L. Verresen, D. von Herrath, Theodore W. Kurtz, Michinobu Hatano, Paola Migliorini, E. Ferrer, A.M. Brownjohn, Kaoru Onoyama, Shizuhiko Watanabe, M.R. Lee, R.F. Gagnon, K. Schaefer, Masato Seki, Itaru Kihara, R.L. Lins, Nobuaki Ohchi, L. Piera, W. Höfer, Carolyn Abitbol, Gaston Zilleruelo, Ursula Rother, J. Madrenas, Jose Strauss, J.B. Young, Yasuhide Mizutani, W. Bosaller, Tetsuro Ikezawa, Max Notohamiprodjo, J.A.B. Keogh, M. Carroll, Pier Vittorio Fosella, T. Horne, K.-U. Eckardt, Clodoveo Ferri, K.E. Britton, S.R. Holdsworth, Jürgen Bommer, Chen H. Hsu, Keiko Yamamoto, Stefano Bombardieri, Eishin Yaoita, Fujio Shimizu, Wataru Mitsuoka, Hiroshi Tsuruda, Eberhard Ritz, Noriyuki Nawa, Giuseppe Gremignai, J.A. Rodríguez, Michael Kirschfink, R. Hirschberg, M. E. De Broe, Masatoshi Fujishima, J. Saupe, W.A. De Backer, Hiroyuki Ohi, J. Monné, Katsutoshi Kawasaki, G. Paleologo, E. Mlodkowska, B. Gallimore, A.W. Asscher, M.V. García-Lucena, S. Codina, Mj. Harber, and E.F. Gaffney

Subjects
Index (economics), business.industry, Statistics, Medicine, Subject (documents), business
Published
1986
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