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Your search keyword '"W.A. Chamley"' showing total 9 results
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9 results on '"W.A. Chamley"'

1. response of relaxin-treated rat uterus to prostaglandins and oxytocin

Author

G.D. Bryant-Greenwood, M.M Bagoyo, and W.A. Chamley

Subjects
Relaxin, medicine.medical_specialty, Contraction (grammar), Biology, Biochemistry, In vitro, Contraction amplitude, Endocrinology, Oxytocin, Internal medicine, Rat uterus, medicine, medicine.drug
Abstract

Paired segments of rat uterus were treated in vitro with relaxin (W1164-3, 150 GPU/mg) until the amplitude of contraction was reduced to at least 50% of the pre-treatment amplitude. Test segments then received 100 ng of either PGE1, PGE2, PGF2α or 250 uU of oxytocin. Control segments remained untreated. There was a significant increase in contraction amplitude in response to the spasmogens (P < 0.05) but no increase was seen in controls.

Published
1977

4. Contents, Vol. 2, 1971/72

Author

G. Chieffi, D.H. Pemberton, J. Rivier, I.A. Cumming, Josephine Milner, K.B. Eik-Nes, M. Amoss, Marion Jackson, W.H. Rotsztejn, W.I.P. Mainwaring, S. Heller, Ghislaine Gallez, Christine Waelbroeck, J. Ghirlanda, G. Copinschi, R. Blackwell, G. Verhoeven, C. Kordon, R.S. Mical, S. Badawy, A.S. Goldman, R. Guillemin, J.-C. Heuson, A. Guitelman, R. Burgus, R. Johansson, L. Iela, M. Rajalakshmi, F.R. Mangan, W.A. Chamley, H.D. Schlumberger, R.E. Mancini, J.M. Brown, A. van den Ende, F. Neumann, J.C. Cerini, R.K. Rastogi, J.K. Findlay, A. Gillespie, F. Gogan, O.M. Cramer, G. Materazzi, R. Massa, H. Hassouna, P.R.K. Reddy, P. de Moor, rez Lloret, Denise E. Bu, Nicole Legros, C.C. Chang, M. Hery, K. Loewit, M. Monahan, Aliza Eshkol, Mildred E.D. Cerini, C. Robyn, R.S. Santti, J.R. Goding, M.D. Cain, L. Martini, W. Vale, K.A. Laurence, M.R.N. Prasad, R.G.A. van Wayjen, B. Scattolini, J.C. Porter, G. Grant, A. Jost, J.L. Pasteels, Shea, N. Ling, B. Lunenfeld, and Lupo di Prisco

Subjects
Reproductive Medicine, Obstetrics and Gynecology
Published
1971

5. Luteal function in sheep injected with prostaglandin F2alpha directly into the corpus luteum

Author

W.A. Chamley and J. D. O'Shea

Subjects
endocrine system, medicine.medical_specialty, medicine.medical_treatment, Luteolysis, Prostaglandin, Ovary, Luteal phase, Biochemistry, chemistry.chemical_compound, Endocrinology, Corpus Luteum, Internal medicine, medicine, Animals, Saline, reproductive and urinary physiology, Prostaglandin f, Progesterone, Histological examination, Sheep, Dose-Response Relationship, Drug, urogenital system, Chemistry, Prostaglandins F, medicine.anatomical_structure, lipids (amino acids, peptides, and proteins), Female, Corpus luteum, hormones, hormone substitutes, and hormone antagonists
Abstract

Groups of ewes received either saline or prostaglandin F2alpha (PGF2alpha) as an injection directly into the corpus luteum. Changes in circulating progesterone levels were measured as well as subsequent histological examination of the corpora lutea. Saline, or PGF2alpha given at the two lower doses (60 and 120 mug respectively), failed to suppress progesterone levels permanently, or to induce degenerative changes in the corpora lutea. Treatment with a higher dose of PGF2alpha (240 mug) was followed by a marked elevation in progesterone levels. These results are discussed in relation to reported effects of PGF2alpha arriving at the ovary via the arterial circulation.

Published
1976

6. Luteal function in sheep with ovarian autotransplants given concurrent infusions of prolactin and prostaglandin F2 alpha into the ovarian artery

Author

J.R. Goding, J.C. Cerini, and W.A. Chamley

Subjects
endocrine system, medicine.medical_specialty, Radioimmunoassay, Prostaglandin, Ovary, Luteal phase, Ovarian artery, Biochemistry, Transplantation, Autologous, chemistry.chemical_compound, Endocrinology, medicine.artery, Internal medicine, medicine, Animals, Progesterone, Sheep, business.industry, Arteries, Prolactin, medicine.anatomical_structure, chemistry, Regional Blood Flow, Depression, Chemical, Prostaglandins, Female, business
Abstract

Four experimental sheep with ovarian autotransplants were infused with prolactin (10 or 100 μg/h), into the ovarian artery, for 6 hours and then prolactin together with prostaglandin F2α (PGF2α) (5 μg/h) for a further 6 hours. A control sheep received PGF2α alone, for 6 hours on two separate occasions. Prolactin failed to overcome the luteolytic action of PGF2α in 3 of the 4 experimental sheep.

Published
1973

7. Failure of prostaglandin F2 to affect LH secretion in the ovariectomized ewe

Author

Margaret Christie and W.A. Chamley

Subjects
medicine.medical_specialty, Pituitary gland, Radioimmunoassay, Prostaglandin, Biochemistry, Tonic (physiology), chemistry.chemical_compound, Endocrinology, Corpus Luteum, Internal medicine, medicine, Animals, Prostaglandin f, Lh secretion, Sheep, Chemistry, Ovary, Luteinizing Hormone, medicine.anatomical_structure, Carotid Arteries, Injections, Intra-Arterial, cardiovascular system, Ovariectomized rat, Prostaglandins, lipids (amino acids, peptides, and proteins), Female, Secretory Rate, hormones, hormone substitutes, and hormone antagonists
Abstract

Prostaglandin F 2α (PGF 2α ) when administered to ovariectomized ewes by intra-carotid infusion did not alter either the pattern of tonic LH secretion or the LH surge evoked by estradiol, indicating that, in the sheep, the luteolytic action of PGF 2α does not involve alteration of LH secretion by the pituitary gland.

Published
1973

8. Luteolysis in sheep with ovarian autotransplants following concurrent infusions of luteinizing hormone and prostaglandin F2 into the ovarian artery

Author

J.K. Findlay, J.R. Goding, Mildred E.D. Cerini, and W.A. Chamley

Subjects
endocrine system, medicine.medical_specialty, Radioimmunoassay, Prostaglandin, Ovarian artery, Biochemistry, Binding, Competitive, Transplantation, Autologous, chemistry.chemical_compound, Endocrinology, In vivo, Corpus Luteum, medicine.artery, Internal medicine, Luteolysis, medicine, Animals, Prostaglandin f, Progesterone, Sheep, business.industry, Ovary, Luteinizing Hormone, Carotid Arteries, chemistry, Injections, Intra-Arterial, Prostaglandins, lipids (amino acids, peptides, and proteins), Female, Luteinizing hormone, business, Secretory Rate, Hormone
Abstract

The luteotrophic properties of LH were examined by determining whether this hormone could overcome the luteolytic action of Prostaglandin F 2α (PGF 2α ) in vivo . Sheep with ovarian autotransplants were given intra-arterial infusions of LH (10 μg/h for 6 h). PGF 2α (5 μg/h) was then added to the infusate and the infusion continued for 6 hours. In all cases, LH failed to counteract the effect of PGF 2α and luteolysis resulted.

Published
1973

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