98 results on '"W. Marijn"'
Search Results
2. Contemporary and past aeolian deposition rates in periglacial conditions (Ebba Valley, central Spitsbergen)
- Author
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Rymer, Krzysztof G., Rachlewicz, Grzegorz, Buchwal, Agata, Temme, Arnaud J.A.M., Reimann, Tony, and van der Meij, W. Marijn
- Published
- 2022
- Full Text
- View/download PDF
3. The Lake Paravani archive – a contribution to the late Quaternary landscape evolution of the Lesser Caucasus (Georgia).
- Author
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Gademann, Daniel, Ustiashvili, Nino, Adikashvili, Luka, Navrozashvili, Levan, Erb‐Satullo, Nathaniel, van der Meij, W. Marijn, Kirkitadze, Giorgi, Koff, Tiiu, Elashvili, Mikheil, Brückner, Helmut, and Laermanns, Hannes
- Subjects
HUMAN settlements ,LAST Glacial Maximum ,POLLEN ,HOLOCENE Epoch ,STEPPES - Abstract
Lake Paravani, located on the volcanic Javakheti Plateau in the central part of the Lesser Caucasus at 2073 m a.s.l., forms a unique geo‐bio‐archive for palaeoenvironmental reconstructions in this remote region. Based on sediment cores from the southwestern part of the lake we expand the existing palynological and sedimentological records beyond the Last Glacial Maximum (LGM). For the first time, it is possible to reconstruct the palaeoenvironment in this part of the Lesser Caucasus back to c. 28 cal. ka BP. Our study shows that until 16 cal. ka BP glacial conditions dominated (Phase I) in the region; there is, however, proof that the lake already existed during the LGM. In the following transitional Phase II from 16 until 6 cal. ka BP, cold and arid conditions with sparse steppe vegetation and a lowered lake level prevailed. Around 10 cal. ka BP, tree pollen started to expand while herbaceous pollen, especially Chenopodiaceae, declined. In Phase III, since 6 cal. ka BP, mixed forest probably represented the Holocene climatic optimum. Fluctuating lake levels indicate shifting climatic conditions. The minor changes of arboreal pollen hin the uppermost part of Phase II may be an indication of human activity. The more humid, vegetation‐rich environment and mild climate around 4.5–2 cal. ka BP correlate with the expansion of the Late Bronze Age settlements in this area (from ~3.5 cal. ka BP/~1.5 ka BC). The proliferation of sites on the plateau, along with even higher‐altitude sites possibly dating to the same period, may indicate that this climate amelioration played an important role in enabling more sustained human occupation. The results extend the record on Lake Paravani by several millennia beyond the LGM and complement the palaeo‐lake reconstructions of the wider region, e.g. at Lake Van (Türkiye) or Lake Sevan (Armenia). [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
4. 10Be and 14C data provide insight on soil mass redistribution along gentle slopes and reveal ancient human impact
- Author
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Calitri, Francesca, Sommer, Michael, van der Meij, W. Marijn, Tikhomirov, Dmitry, Christl, Marcus, and Egli, Markus
- Published
- 2021
- Full Text
- View/download PDF
5. Mixed signals: interpreting mixing patterns of different soil bioturbation processes through luminescence and numerical modelling
- Author
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van der Meij, W. Marijn, primary, Riedesel, Svenja, additional, and Reimann, Tony, additional
- Published
- 2024
- Full Text
- View/download PDF
6. 3–4D soil model as challenge for future soil research: Quantitative soil modeling based on the solid phase
- Author
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Horst H. Gerke, Hans‐Jörg Vogel, Tobias K.D. Weber, W. Marijn van der Meij, and Thomas Scholten
- Subjects
Soil Science ,Plant Science - Published
- 2022
- Full Text
- View/download PDF
7. ChronoLorica: introduction of a soil–landscape evolution model combined with geochronometers
- Author
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W. Marijn van der Meij, Arnaud J. A. M. Temme, Steven A. Binnie, and Tony Reimann
- Subjects
General Engineering - Abstract
Understanding long-term soil and landscape evolution can help us understand the threats to current-day soils, landscapes and their functions. The temporal evolution of soils and landscapes can be studied using geochronometers, such as optically stimulated luminescence (OSL) particle ages or radionuclide inventories. Also, soil–landscape evolution models (SLEMs) can be used to study the spatial and temporal evolution of soils and landscapes through numerical modelling of the processes responsible for the evolution. SLEMs and geochronometers have been combined in the past, but often these couplings focus on a single geochronometer, are designed for specific idealized landscape positions, or do not consider multiple transport processes or post-depositional mixing processes that can disturb the geochronometers in sedimentary archives. We present ChronoLorica, a coupling of the soil–landscape evolution model Lorica with a geochronological module. The module traces spatiotemporal patterns of particle ages, analogous to OSL ages, and radionuclide inventories during the simulations of soil and landscape evolution. The geochronological module opens rich possibilities for data-based calibration of simulated model processes, which include natural processes, such as bioturbation and soil creep, as well as anthropogenic processes, such as tillage. Moreover, ChronoLorica can be applied to transient landscapes that are subject to complex, non-linear boundary conditions, such as land use intensification, and processes of post-depositional disturbance which often result in complex geo-archives. In this contribution, we illustrate the model functionality and applicability by simulating soil and landscape evolution along a two-dimensional hillslope. We show how the model simulates the development of the following three geochronometers: OSL particle ages, meteoric 10Be inventories and in situ 10Be inventories. The results are compared with field observations from comparable landscapes. We also discuss the limitations of the model and highlight its potential applications in pedogenical, geomorphological or geological studies.
- Published
- 2023
8. Evolutionary pathways in soil-landscape evolution models
- Author
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van der Meij and W. Marijn
- Subjects
Soil management ,Soil model ,Land use ,business.industry ,Soil water ,Environmental resource management ,Sustainability ,Environmental science ,Soil Science ,Context (language use) ,business ,Large model ,Variety (cybernetics) - Abstract
Soils and landscapes can show complex, non-linear evolution, especially under changing climate or land use. Soil-landscape evolution models (SLEMs) are increasingly equipped to simulate the development of soils and landscapes over long timescales under these changing drivers, but provide large data output that can be difficult to interpret and communicate. New tools are required to analyse and communicate large model output. In this work, I show how spatial and temporal trends in previously published model results can be summarized and conceptualized with evolutionary pathways, which are possible trajectories of the development of soil patterns. Simulated differences in rainfall and land use control progressive or regressive soil development and convergence or divergence of the soil pattern. These changes are illustrated with real-world examples of soil development and soil complexity. The use of evolutionary pathways for analysing the results of SLEMs is not limited to the examples in this paper, but they can be used on a wide variety of soil properties, soil pattern statistics and models. With that, evolutionary pathways provide a promising tool to analyse and communicate soil model output, not only for studying past changes in soils, but also for evaluating future spatial and temporal effects of soil management practices in the context of sustainability.
- Published
- 2022
- Full Text
- View/download PDF
9. ChronoLorica – Introduction of a soil-landscape evolution model combined with geochronometers
- Author
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W. Marijn van der Meij, Arnaud J. A. M. Temme, Steven A. Binnie, and Tony Reimann
- Abstract
Understanding long-term soil and landscape evolution can help us understand the threats to current-day soils, landscapes and their functions. The temporal evolution of soils and landscapes can be studied using geochronometers, such as optically stimulated luminescence (OSL) particle ages or radionuclide inventories. Also, soil–landscape evolution models (SLEMs) can be used to study the spatial and temporal evolution of soils and landscapes through numerical modelling of the processes responsible for the evolution. SLEMs and geochronometers have been combined in the past, but often these couplings focus on a single geochronometer, are designed for specific idealized landscape positions, or do not consider multiple transport processes or post-depositional mixing processes that can disturb the geochronometers in sedimentary archives. We present ChronoLorica, a coupling of the soil–landscape evolution model Lorica with a geochronological module. The module traces spatiotemporal patterns of particle ages, analogous to OSL ages, and radionuclide inventories during the simulations of soil and landscape evolution. The geochronological module opens rich possibilities for data-based calibration of simulated model processes, which include natural processes, such as bioturbation and soil creep, as well as anthropogenic processes, such as tillage. Moreover, ChronoLorica can be applied to transient landscapes that are subject to complex, non-linear boundary conditions, such as land use intensification, and processes of post-depositional disturbance which often result in complex geo-archives. In this contribution, we illustrate the model functionality and applicability by simulating soil and landscape evolution along a two-dimensional hillslope. We show how the model simulates the development of the following three geochronometers: OSL particle ages, meteoric 10Be inventories and in situ 10Be inventories. The results are compared with field observations from comparable landscapes. We also discuss the limitations of the model and highlight its potential applications in pedogenical, geomorphological or geological studies.
- Published
- 2022
- Full Text
- View/download PDF
10. 3–4D soil model as challenge for future soil research: Quantitative soil modeling based on the solid phase
- Author
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Gerke, Horst H., primary, Vogel, Hans‐Jörg, additional, Weber, Tobias K.D., additional, van der Meij, W. Marijn, additional, and Scholten, Thomas, additional
- Published
- 2022
- Full Text
- View/download PDF
11. ChronoLorica – Introduction of a soil-landscape evolution model combined with geochronometers
- Author
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van der Meij, W. Marijn, primary, Temme, Arnaud J. A. M., additional, Binnie, Steven A., additional, and Reimann, Tony, additional
- Published
- 2022
- Full Text
- View/download PDF
12. A Sign of Superspreading in Tuberculosis: Highly Skewed Distribution of Genotypic Cluster Sizes
- Author
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Ypma, Rolf J. F., Altes, Hester Korthals, van Soolingen, Dick, Wallinga, Jacco, and van Ballegooijen, W. Marijn
- Published
- 2013
- Full Text
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13. Genetic Data Provide Evidence for Wind-Mediated Transmission of Highly Pathogenic Avian Influenza
- Author
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Ypma, Rolf J.F., Jonges, Marcel, Bataille, Arnaud, Stegeman, Arjan, Koch, Guus, van Boven, Michiel, Koopmans, Marion, van Ballegooijen, W. Marijn, and Wallinga, Jacco
- Published
- 2013
- Full Text
- View/download PDF
14. Comparing geomorphological maps made manually and by deep learning
- Author
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van der Meij, W. Marijn, Meijles, Erik W., Marcos, Diego, Harkema, Tom T. L., Candel, Jasper H. J., Maas, Gilbert J., van der Meij, W. Marijn, Meijles, Erik W., Marcos, Diego, Harkema, Tom T. L., Candel, Jasper H. J., and Maas, Gilbert J.
- Abstract
Geomorphological maps provide information on the relief, genesis and shape of the earth's surface and are widely used in sustainable spatial developments. The quality of geomorphological maps is however rarely assessed or reported, which limits their applicability. Moreover, older geomorphological maps often do not meet current quality requirements and require updating. This updating is time-consuming and because of its qualitative nature difficult to reproduce, but can be supported by novel computational methods. In this paper, we address these issues by (1) quantifying the uncertainty associated with manual geomorphological mapping, (2) exploring the use of convolutional neural networks (CNNs) for semi-automated geomorphological mapping and (3) testing the sensitivity of CNNs to uncertainties in manually created evaluation data. We selected a test area in the Dutch push-moraine district with a pronounced relief and a high variety of landforms. For this test area we developed five manually created geomorphological maps and 27 automatically created landform maps using CNNs. The resulting manual maps are similar on a regional level. We could identify the causes of disagreement between the maps on a local level, which often related to differences in mapping experience, choices in delineation and different interpretations of the legend. Coordination of mapping efforts and field validation are necessary to create accurate and precise maps. CNNs perform well in identifying landforms and geomorphological units, but fail at correct delineation. The human geomorphologist remains necessary to correct the delineation and classification of the computed maps. The uncertainty in the manually created data that are used to train and evaluate CNNs have a large effect on the model performance and evaluation. This also advocates for coordinated mapping efforts to ensure the quality of manually created training and test data. Further model development and data processing are required
- Published
- 2022
15. Evolutionary pathways in soil-landscape evolution models
- Author
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van der Meij, W. Marijn and van der Meij, W. Marijn
- Abstract
Soils and landscapes can show complex, nonlinear evolution, especially under changing climate or land use. Soil-landscape evolution models (SLEMs) are increasingly equipped to simulate the development of soils and landscapes over long timescales under these changing drivers, but provide large data output that can be difficult to interpret and communicate. New tools are required to analyze and visualize large model outputs. In this work, I show how spatial and temporal trends in previously published model results can be analyzed and visualized with evolutionary pathways, which are possible trajectories of the development of soils. Simulated differences in rainfall and land use control progressive or regressive soil development and convergence or divergence of the soil pattern. These changes are illustrated with real-world examples of soil development and soil complexity. The use of evolutionary pathways for analyzing the results of SLEMs is not limited to the examples in this paper, but they can be used on a wide variety of soil properties, soil pattern statistics and models. With that, evolutionary pathways provide a promising tool to analyze and visualize soil model output, not only for studying past changes in soils, but also for evaluating future spatial and temporal effects of soil management practices in the context of sustainability.
- Published
- 2022
16. 3-4D soil model as challenge for future soil research: Quantitative soil modeling based on the solid phase
- Author
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Gerke, Horst H., Vogel, Hans-Joerg, Weber, Tobias K. D., van der Meij, W. Marijn, Scholten, Thomas, Gerke, Horst H., Vogel, Hans-Joerg, Weber, Tobias K. D., van der Meij, W. Marijn, and Scholten, Thomas
- Abstract
A 3-4D soil model represents a logical step forward from one-dimensional soil columns (1D), two-dimensional soil maps (2D), and three-dimensional soil volumes (3D) toward dynamic soil models (4D), with time as the fourth dimension. The challenge is to develop modeling tools that account for the states of soil properties, including the spatial structure of solids and pores, as well as their dynamics, including soil mass and solute transfers in landscapes. Our envisioned 3-4D soil model approach aims at improving the capability to predict fundamental soil functions (e.g., plant growth, storage, matter fluxes) that provide ecosystem services in the socioeconomic context. This study provides a structured overview on current soil models, challenges, open questions, and urgent research needs for developing a 3-4D soil model. A 3-4D soil model should provide an inventory of spatially distributed and temporally variable soil properties. As basis for this, we propose a mass balance model for the solid phase, which needs to be supplemented by a model describing its structure. This should eventually provide adequate 3D parameter sets for the numerical modeling of soil functions (e.g., flow and transport). The target resolution is decameters in the horizontal plane and centimeters to decimeters in the vertical direction to represent characteristic soil properties and soil horizons. The actual state of soils and their properties can be estimated from spatial data that represent the soil forming factors, with the use of machine learning tools. Improved modeling of the dynamics of soil bulk density, biological processes, and the pore structure are required to relate the solid mass balance to matter fluxes. A 3-4D soil model can be built from several types of modeling approaches. We distinguish between (1) process models that simulate mass balances, fluxes and soil structure dynamics, (2) statistical pedometric models using machine learning and geostatistics to estimate the soil in
- Published
- 2022
17. Nowcasting pandemic influenza A/H1N1 2009 hospitalizations in the Netherlands
- Author
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Donker, Tjibbe, van Boven, Michiel, van Ballegooijen, W. Marijn, van't Klooster, Tessa M., Wielders, Cornelia C., and Wallinga, Jacco
- Published
- 2011
18. Comparing geomorphological maps made manually and by deep learning
- Author
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W. Marijn Meij, Erik W. Meijles, Diego Marcos, Tom T. L. Harkema, Jasper H. J. Candel, Gilbert J. Maas, and Urban and Regional Studies Institute
- Subjects
Water en Landgebruik ,Water and Land Use ,Geography, Planning and Development ,convolutional neural network ,deep learning ,The Netherlands ,geomorphology ,PE&RC ,Bodem, Water en Landgebruik ,Soil ,Bodemgeografie en Landschap ,Bodem ,Soil, Water and Land Use ,Laboratory of Geo-information Science and Remote Sensing ,Earth and Planetary Sciences (miscellaneous) ,Soil Geography and Landscape ,Laboratorium voor Geo-informatiekunde en Remote Sensing ,geomorphological map ,mapping ,uncertainty ,Earth-Surface Processes - Abstract
Geomorphological maps provide information on the relief, genesis and shape of the earth's surface and are widely used in sustainable spatial developments. The quality of geomorphological maps is however rarely assessed or reported, which limits their applicability. Moreover, older geomorphological maps often do not meet current quality requirements and require updating. This updating is time-consuming and because of its qualitative nature difficult to reproduce, but can be supported by novel computational methods. In this paper, we address these issues by (1) quantifying the uncertainty associated with manual geomorphological mapping, (2) exploring the use of convolutional neural networks (CNNs) for semi-automated geomorphological mapping and (3) testing the sensitivity of CNNs to uncertainties in manually created evaluation data. We selected a test area in the Dutch push-moraine district with a pronounced relief and a high variety of landforms. For this test area we developed five manually created geomorphological maps and 27 automatically created landform maps using CNNs. The resulting manual maps are similar on a regional level. We could identify the causes of disagreement between the maps on a local level, which often related to differences in mapping experience, choices in delineation and different interpretations of the legend. Coordination of mapping efforts and field validation are necessary to create accurate and precise maps. CNNs perform well in identifying landforms and geomorphological units, but fail at correct delineation. The human geomorphologist remains necessary to correct the delineation and classification of the computed maps. The uncertainty in the manually created data that are used to train and evaluate CNNs have a large effect on the model performance and evaluation. This also advocates for coordinated mapping efforts to ensure the quality of manually created training and test data. Further model development and data processing are required before CNNs can act as standalone mapping techniques.
- Published
- 2022
19. New geomorphometric variables for non-continuous hillslopes – Assessing the value for digital soil mapping
- Author
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Arnaud J. Temme, Jeroen M. Schoorl, and W. Marijn van der Meij
- Subjects
Geomorphometry ,Bodemgeografie en Landschap ,Digital soil mapping ,Geomorphometric variable ,Slope break ,Cliff ,Soil Geography and Landscape ,Soil Science ,PE&RC ,Lynchet - Abstract
We present a set of new geomorphometric variables that express landscape position relative to breaklines in hillslopes, and test whether these variables are of value in explaining soil property variation in three study sites in the United States, the Netherlands, and Spain. Underlying this work is the recognition that slope breaks, such as cliff lines, lynchets, and large slumped blocks, are associated with processes that affect soil formation around them. For each study site, we digitized slope breaks and calculated vertical and horizontal distance to the nearest lower and higher slope breaks, as well as the relative position between multiple slope breaks, the slope increase at the next higher slope break, and the slope decrease at the next lower slope break. We then assessed the value of these geomorphometric variables in the prediction of slope properties by simple linear regression. At each study site, models were fitted to existing soil observations using a traditional set of geomorphometric variables, and the traditional set plus our newly developed variables. Model comparison indicated that the new variables substantially improved model fit and reduced model error for the site in the United States (Kansas, n = 100), improved model fit but did not reduce model error for the site in the Netherlands (Limburg, n = 192), and did not solve model overfitting issues for the small dataset in Spain (Malaga, n = 66).
- Published
- 2022
20. Comparing geomorphological maps made manually and by deep learning
- Author
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Meij, W. Marijn, primary, Meijles, Erik W., additional, Marcos, Diego, additional, Harkema, Tom T. L., additional, Candel, Jasper H. J., additional, and Maas, Gilbert J., additional
- Published
- 2022
- Full Text
- View/download PDF
21. ChronoLorica: introduction of a soil–landscape evolution model combined with geochronometers.
- Author
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van der Meij, W. Marijn, Temme, Arnaud J. A. M., Binnie, Steven A., and Reimann, Tony
- Subjects
OPTICALLY stimulated luminescence ,SOIL creep - Abstract
Understanding long-term soil and landscape evolution can help us understand the threats to current-day soils, landscapes and their functions. The temporal evolution of soils and landscapes can be studied using geochronometers, such as optically stimulated luminescence (OSL) particle ages or radionuclide inventories. Also, soil–landscape evolution models (SLEMs) can be used to study the spatial and temporal evolution of soils and landscapes through numerical modelling of the processes responsible for the evolution. SLEMs and geochronometers have been combined in the past, but often these couplings focus on a single geochronometer, are designed for specific idealized landscape positions, or do not consider multiple transport processes or post-depositional mixing processes that can disturb the geochronometers in sedimentary archives. We present ChronoLorica, a coupling of the soil–landscape evolution model Lorica with a geochronological module. The module traces spatiotemporal patterns of particle ages, analogous to OSL ages, and radionuclide inventories during the simulations of soil and landscape evolution. The geochronological module opens rich possibilities for data-based calibration of simulated model processes, which include natural processes, such as bioturbation and soil creep, as well as anthropogenic processes, such as tillage. Moreover, ChronoLorica can be applied to transient landscapes that are subject to complex, non-linear boundary conditions, such as land use intensification, and processes of post-depositional disturbance which often result in complex geo-archives. In this contribution, we illustrate the model functionality and applicability by simulating soil and landscape evolution along a two-dimensional hillslope. We show how the model simulates the development of the following three geochronometers: OSL particle ages, meteoric 10 Be inventories and in situ 10 Be inventories. The results are compared with field observations from comparable landscapes. We also discuss the limitations of the model and highlight its potential applications in pedogenical, geomorphological or geological studies. [ABSTRACT FROM AUTHOR]
- Published
- 2023
- Full Text
- View/download PDF
22. Evolutionary pathways in soil-landscape evolution models
- Author
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van der Meij, W. Marijn, primary
- Published
- 2021
- Full Text
- View/download PDF
23. ChronoLorica – Introduction of a soil-landscape evolution model combined with geochronometers.
- Author
-
Meij, W. Marijn van der, Temme, Arnaud J. A. M., Binnie, Steven A., and Reimann, Tony
- Subjects
GEOCHRONOMETRY ,RADIOISOTOPES ,SPATIOTEMPORAL processes ,SOIL formation ,ANTHROPOGENIC effects on nature - Abstract
Understanding long-term soil and landscape evolution can help us understand the threats to current-day soils, landscapes and their functions. The temporal evolution of soils and landscapes can be studied using geochronometers, such as OSL particle ages or radionuclide inventories. Also, soil-landscape evolution models (SLEMs) can be used to study the spatial and temporal evolution of soils and landscapes through numerical modelling of the processes responsible for the evolution. SLEMs and geochronometers have been combined in the past, but often these couplings focus on a single geochronometer, are designed for specific idealized landscape positions or do not consider multiple transport processes or post-depositional mixing processes that can disturb the geochronometers in sedimentary archives. We present a coupling of soil-landscape evolution model Lorica with a geochronological module, named ChronoLorica. The module traces spatiotemporal patterns of particle ages, analogous to OSL ages, and radionuclide inventories during the simulations of soil and landscape evolution. The geochronological module opens rich possibilities for data-based calibration of simulated model processes, which include natural processes, such as bioturbation and soil creep, as well as anthropogenic processes, such as tillage. Moreover, ChronoLorica can be applied to transient landscapes that are subject to complex boundary conditions, such as land use intensification, and processes of post-depositional disturbance which often result in complex geo-archives. In this contribution, we illustrate the model functionality and applicability by simulating soil and landscape evolution along a two-dimensional hillslope. We show how the model simulates the development of two geochronometers: OSL particle ages and cosmogenic nuclide inventories. The results are compared with field observations from comparable landscapes. We also discuss the limitations of the model and highlight its potential applications in pedogenical, geomorphological or geological studies. [ABSTRACT FROM AUTHOR]
- Published
- 2022
- Full Text
- View/download PDF
24. 10Be and 14C data provide insight on soil mass redistribution along gentle slopes and reveal ancient human impact
- Author
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Francesca Calitri, Marcus Christl, W. Marijn van der Meij, Michael Sommer, Dmitry Tikhomirov, Markus Egli, University of Zurich, and Calitri, Francesca
- Subjects
10Be ,Soil mass ,Stratigraphy ,1904 Earth-Surface Processes ,Soil science ,Earth ,Vegetation ,Redistribution (cultural anthropology) ,complex mixtures ,Soil redistribution ,Catena ,Pedogenesis ,10122 Institute of Geography ,Surface Processes ,Erosion ,Soil water ,Forest ,910 Geography & travel ,1913 Stratigraphy ,Bioturbation ,Geology ,Earth-Surface Processes - Abstract
Purpose Spatial and temporal patterns of past erosional events are a useful and needed information to explain observed soil patterns in different landscapes. Soil thickness reflects the overall expression of pedogenesis and erosion. Forested soils of Northern Germany exhibit varying soil thicknesses with thin soils on crest positions and buried soils at the footslope. The aim of this study is to reconstruct the complex soil mass redistribution and soil patterns of this forested area due to different periods of erosion and stability. Methods We explored the explanatory power of both 10Be (in situ and meteoric) on a hillslope and we 14C-dated buried horizons at different depths. Results The 10Be depth profiles did not show an exponential decrease with depth. They had a ‘bulge’ shape indicating clay translocation and interaction with oxyhydroxydes (meteoric 10Be), bioturbation and soil mass redistribution (in situ 10Be). The combined application of both 10Be and 14C dating revealed progressive and regressive phases of soil evolution. Although Melzower Forest is protected (same vegetation) since the past 250 years, both 10Be clearly indicated major soil mass redistribution along the investigated catena. Conclusion A strong erosion impulse must have occurred between 4.5 and 6.8 kyr BP indicating an earlier human impact on soil erosion than previously postulated (~ 3 kyr earlier). Our findings correlate in fact with the first settlements reported for this region (~ 6.8 kyr BP) and show their immediate effect on soils. The overall soil redistribution rates in this forest are surprisingly similar to those obtained from a nearby agricultural area., Journal of Soils and Sediments, 21 (12), ISSN:1439-0108, ISSN:1614-7480
- Published
- 2021
- Full Text
- View/download PDF
25. Be-10 and C-14 data provide insight on soil mass redistribution along gentle slopes and reveal ancient human impact
- Author
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Calitri, Francesca, Sommer, Michael, van der Meij, W. Marijn, Tikhomirov, Dmitry, Christl, Marcus, Egli, Markus, Calitri, Francesca, Sommer, Michael, van der Meij, W. Marijn, Tikhomirov, Dmitry, Christl, Marcus, and Egli, Markus
- Abstract
Purpose Spatial and temporal patterns of past erosional events are a useful and needed information to explain observed soil patterns in different landscapes. Soil thickness reflects the overall expression of pedogenesis and erosion. Forested soils of Northern Germany exhibit varying soil thicknesses with thin soils on crest positions and buried soils at the footslope. The aim of this study is to reconstruct the complex soil mass redistribution and soil patterns of this forested area due to different periods of erosion and stability. Methods We explored the explanatory power of both Be-10 (in situ and meteoric) on a hillslope and we C-14-dated buried horizons at different depths. Results The Be-10 depth profiles did not show an exponential decrease with depth. They had a 'bulge' shape indicating clay translocation and interaction with oxyhydroxydes (meteoric Be-10), bioturbation and soil mass redistribution (in situ Be-10). The combined application of both Be-10 and C-14 dating revealed progressive and regressive phases of soil evolution. Although Melzower Forest is protected (same vegetation) since the past 250 years, both Be-10 clearly indicated major soil mass redistribution along the investigated catena. Conclusion A strong erosion impulse must have occurred between 4.5 and 6.8 kyr BP indicating an earlier human impact on soil erosion than previously postulated (similar to 3 kyr earlier). Our findings correlate in fact with the first settlements reported for this region (similar to 6.8 kyr BP) and show their immediate effect on soils. The overall soil redistribution rates in this forest are surprisingly similar to those obtained from a nearby agricultural area.
- Published
- 2021
26. $^{10}$Be and $^{14}$C data provide insight on soil mass redistribution along gentle slopes and reveal ancient human impact
- Author
-
Calitri, Francesca; https://orcid.org/0000-0002-1798-9586, Sommer, Michael, van der Meij, W Marijn, Tikhomirov, Dmitry; https://orcid.org/0000-0001-5266-4077, Christl, Marcus; https://orcid.org/0000-0002-3131-6652, Egli, Markus; https://orcid.org/0000-0002-1528-3440, Calitri, Francesca; https://orcid.org/0000-0002-1798-9586, Sommer, Michael, van der Meij, W Marijn, Tikhomirov, Dmitry; https://orcid.org/0000-0001-5266-4077, Christl, Marcus; https://orcid.org/0000-0002-3131-6652, and Egli, Markus; https://orcid.org/0000-0002-1528-3440
- Abstract
Purpose: Spatial and temporal patterns of past erosional events are a useful and needed information to explain observed soil patterns in different landscapes. Soil thickness reflects the overall expression of pedogenesis and erosion. Forested soils of Northern Germany exhibit varying soil thicknesses with thin soils on crest positions and buried soils at the footslope. The aim of this study is to reconstruct the complex soil mass redistribution and soil patterns of this forested area due to different periods of erosion and stability. Methods: We explored the explanatory power of both $^{10}$Be (in situ and meteoric) on a hillslope and we $^{14}$C-dated buried horizons at different depths. Results: The $^{10}$Be depth profiles did not show an exponential decrease with depth. They had a ‘bulge’ shape indicating clay translocation and interaction with oxyhydroxydes (meteoric $^{10}$Be), bioturbation and soil mass redistribution (in situ $^{10}$Be). The combined application of both $^{10}$Be and $^{14}$C dating revealed progressive and regressive phases of soil evolution. Although Melzower Forest is protected (same vegetation) since the past 250 years, both $^{10}$Be clearly indicated major soil mass redistribution along the investigated catena. Conclusion: A strong erosion impulse must have occurred between 4.5 and 6.8 kyr BP indicating an earlier human impact on soil erosion than previously postulated (~ 3 kyr earlier). Our findings correlate in fact with the first settlements reported for this region (~ 6.8 kyr BP) and show their immediate effect on soils. The overall soil redistribution rates in this forest are surprisingly similar to those obtained from a nearby agricultural area.
- Published
- 2021
27. Contemporary and past aeolian deposition rates in periglacial conditions (Ebba Valley, central Spitsbergen)
- Author
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Krzysztof G. Rymer, Grzegorz Rachlewicz, Agata Buchwal, Arnaud J.A.M. Temme, Tony Reimann, and W. Marijn van der Meij
- Subjects
Earth-Surface Processes - Published
- 2022
- Full Text
- View/download PDF
28. Finding evidence for local transmission of contagious disease in molecular epidemiological datasets.
- Author
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Rolf J F Ypma, Tjibbe Donker, W Marijn van Ballegooijen, and Jacco Wallinga
- Subjects
Medicine ,Science - Abstract
Surveillance systems of contagious diseases record information on cases to monitor incidence of disease and to evaluate effectiveness of interventions. These systems focus on a well-defined population; a key question is whether observed cases are infected through local transmission within the population or whether cases are the result of importation of infection into the population. Local spread of infection calls for different intervention measures than importation of infection. Besides standardized information on time of symptom onset and location of cases, pathogen genotyping or sequencing offers essential information to address this question. Here we introduce a method that takes full advantage of both the genetic and epidemiological data to distinguish local transmission from importation of infection, by comparing inter-case distances in temporal, spatial and genetic data. Cases that are part of a local transmission chain will have shorter distances between their geographical locations, shorter durations between their times of symptom onset and shorter genetic distances between their pathogen sequences as compared to cases that are due to importation. In contrast to generic clustering algorithms, the proposed method explicitly accounts for the fact that during local transmission of a contagious disease the cases are caused by other cases. No pathogen-specific assumptions are needed due to the use of ordinal distances, which allow for direct comparison between the disparate data types. Using simulations, we test the performance of the method in identifying local transmission of disease in large datasets, and assess how sensitivity and specificity change with varying size of local transmission chains and varying overall disease incidence.
- Published
- 2013
- Full Text
- View/download PDF
29. Emergent trade-offs and selection for outbreak frequency in spatial epidemics
- Author
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van Ballegooijen, W. Marijn and Boerlijst, Maarten C.
- Subjects
Pathogenic microorganisms -- Research ,Spatial behavior -- Research ,Science and technology - Abstract
Nonspatial theory on pathogen evolution generally predicts selection for maximal number of secondary infections, constrained only by supposed physiological trade-offs between pathogen infectiousness and virulence. Spread of diseases in human populations can, however, exhibit large scale patterns, underlining the need for spatially explicit approaches to pathogen evolution. Here, we show, in a spatial model where all pathogen traits are allowed to evolve independently, that evolutionary trajectories follow a single relationship between transmission and clearance. This tradeoff relation is an emergent system property, as opposed to being a property of pathogen physiology, and maximizes outbreak frequency instead of the number of secondary infections. We conclude that spatial pattern formation in contact networks can act to link infectiousness and clearance during pathogen evolution in the absence of any physiological trade-off. Selection for outbreak frequency offers an explanation for the evolution of pathogens that cause mild but frequent infections. evolution | pathogen | spatial model | spatial patterns
- Published
- 2004
30. Modeling soil and landscape evolution – the effect of rainfall and land-use change on soil and landscape patterns
- Author
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van der Meij, W. Marijn, primary, Temme, Arnaud J. A. M., additional, Wallinga, Jakob, additional, and Sommer, Michael, additional
- Published
- 2020
- Full Text
- View/download PDF
31. Molecular Sequence Data of Hepatitis B Virus and Genetic Diversity After Vaccination
- Author
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van Ballegooijen, W Marijn, van Houdt, Robin, Bruisten, Sylvia M., Boot, Hein J., Coutinho, Roel A., and Wallinga, Jacco
- Published
- 2009
32. Van Ballegooijen et al. Respond to “Evaluating Vaccination Programs Using Genetic Sequence Data”
- Author
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van Ballegooijen, W Marijn, van Houdt, Robin, Bruisten, Sylvia M., Boot, Hein J., Coutinho, Roel A., and Wallinga, Jacco
- Published
- 2009
33. 10Be and 14C data provide insight on soil mass redistribution along gentle slopes and reveal ancient human impact.
- Author
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Calitri, Francesca, Sommer, Michael, van der Meij, W. Marijn, Tikhomirov, Dmitry, Christl, Marcus, and Egli, Markus
- Subjects
SOIL depth ,SOILS ,SOIL erosion ,DEPTH profiling ,EROSION ,FORESTED wetlands - Abstract
Purpose: Spatial and temporal patterns of past erosional events are a useful and needed information to explain observed soil patterns in different landscapes. Soil thickness reflects the overall expression of pedogenesis and erosion. Forested soils of Northern Germany exhibit varying soil thicknesses with thin soils on crest positions and buried soils at the footslope. The aim of this study is to reconstruct the complex soil mass redistribution and soil patterns of this forested area due to different periods of erosion and stability. Methods: We explored the explanatory power of both
10 Be (in situ and meteoric) on a hillslope and we14 C-dated buried horizons at different depths. Results: The10 Be depth profiles did not show an exponential decrease with depth. They had a 'bulge' shape indicating clay translocation and interaction with oxyhydroxydes (meteoric10 Be), bioturbation and soil mass redistribution (in situ10 Be). The combined application of both10 Be and14 C dating revealed progressive and regressive phases of soil evolution. Although Melzower Forest is protected (same vegetation) since the past 250 years, both10 Be clearly indicated major soil mass redistribution along the investigated catena. Conclusion: A strong erosion impulse must have occurred between 4.5 and 6.8 kyr BP indicating an earlier human impact on soil erosion than previously postulated (~ 3 kyr earlier). Our findings correlate in fact with the first settlements reported for this region (~ 6.8 kyr BP) and show their immediate effect on soils. The overall soil redistribution rates in this forest are surprisingly similar to those obtained from a nearby agricultural area. [ABSTRACT FROM AUTHOR]- Published
- 2021
- Full Text
- View/download PDF
34. Modelling soil and landscape evolution – the effect of rainfall and land use change on soil and landscape patterns
- Author
-
W. Marijn van der Meij, Arnaud J. A. M. Temme, Jakob Wallinga, and Michael Sommer
- Abstract
Humans have substantially altered soil and landscape patterns and properties due to agricultural use, with severe impacts on biodiversity, carbon sequestration and food security. These impacts are difficult to quantify, because we lack data on long-term changes in soils in natural and agricultural settings and available simulation methods are not suitable to reliably predict future development of soils under projected changes in climate and land management. To help overcome these challenges, we developed the HydroLorica soil-landscape evolution model, that simulates soil development by explicitly modelling the spatial water balance as driver of soil and landscape forming processes. We simulated 14500 years of soil – formation under natural conditions for three scenarios of different rainfall inputs. For each scenario we added a 500-year period of intensive agricultural land use, where we introduced tillage erosion and changed vegetation type. Our results show substantial differences between natural soil patterns under different rainfall input. With higher rainfall, soil patterns become more heterogeneous due to increased tree throw and water erosion. Agricultural patterns differ substantially from the natural patterns, with higher variation of soil properties over larger distances and larger correlations with terrain position. In the natural system, rainfall is the dominant factor influencing soil variation, while for agricultural soil patterns landform explains most of the variation simulated. The cultivation of soils thus changed the dominant factors and processes influencing soil formation, and thereby also increased predictability of soil patterns. Our study highlights the potential of soil-landscape evolution modelling for simulating past and future developments of soil and landscape patterns. Our results confirm that humans have become the dominant soil forming factor in agricultural landscapes.
- Published
- 2019
35. Supplementary material to 'Modelling soil and landscape evolution – the effect of rainfall and land use change on soil and landscape patterns'
- Author
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W. Marijn van der Meij, Arnaud J. A. M. Temme, Jakob Wallinga, and Michael Sommer
- Published
- 2019
- Full Text
- View/download PDF
36. Modelling soil and landscape evolution – the effect of rainfall and land use change on soil and landscape patterns
- Author
-
van der Meij, W. Marijn, primary, Temme, Arnaud J. A. M., additional, Wallinga, Jakob, additional, and Sommer, Michael, additional
- Published
- 2019
- Full Text
- View/download PDF
37. Supplementary material to "Modelling soil and landscape evolution – the effect of rainfall and land use change on soil and landscape patterns"
- Author
-
van der Meij, W. Marijn, primary, Temme, Arnaud J. A. M., additional, Wallinga, Jakob, additional, and Sommer, Michael, additional
- Published
- 2019
- Full Text
- View/download PDF
38. Relating Phylogenetic Trees to Transmission Trees of Infectious Disease Outbreaks
- Author
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Rolf J. F. Ypma, Jacco Wallinga, and W. Marijn van Ballegooijen
- Subjects
Disease ,Biology ,Investigations ,Disease Outbreaks ,Phylogenetics ,Influenza, Human ,Disease Transmission, Infectious ,Genetics ,Animals ,Humans ,Computer Simulation ,Phylogeny ,Probability ,Likelihood Functions ,Models, Statistical ,Molecular epidemiology ,Phylogenetic tree ,Models, Genetic ,Outbreak ,Infectious Disease Epidemiology ,Virology ,Viral phylodynamics ,Infectious disease (medical specialty) ,Evolutionary biology ,Foot-and-Mouth Disease ,Host-Pathogen Interactions ,Mutation - Abstract
Transmission events are the fundamental building blocks of the dynamics of any infectious disease. Much about the epidemiology of a disease can be learned when these individual transmission events are known or can be estimated. Such estimations are difficult and generally feasible only when detailed epidemiological data are available. The genealogy estimated from genetic sequences of sampled pathogens is another rich source of information on transmission history. Optimal inference of transmission events calls for the combination of genetic data and epidemiological data into one joint analysis. A key difficulty is that the transmission tree, which describes the transmission events between infected hosts, differs from the phylogenetic tree, which describes the ancestral relationships between pathogens sampled from these hosts. The trees differ both in timing of the internal nodes and in topology. These differences become more pronounced when a higher fraction of infected hosts is sampled. We show how the phylogenetic tree of sampled pathogens is related to the transmission tree of an outbreak of an infectious disease, by the within-host dynamics of pathogens. We provide a statistical framework to infer key epidemiological and mutational parameters by simultaneously estimating the phylogenetic tree and the transmission tree. We test the approach using simulations and illustrate its use on an outbreak of foot-and-mouth disease. The approach unifies existing methods in the emerging field of phylodynamics with transmission tree reconstruction methods that are used in infectious disease epidemiology.
- Published
- 2013
- Full Text
- View/download PDF
39. Nowcasting pandemic influenza A/H1N1 2009 hospitalizations in the Netherlands
- Author
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Tessa M. van’t Klooster, W. Marijn van Ballegooijen, Jacco Wallinga, Michiel van Boven, Cornelia C. Wielders, Tjibbe Donker, and Faculteit Medische Wetenschappen/UMCG
- Subjects
medicine.medical_specialty ,Disease notification ,Epidemiology ,medicine.disease_cause ,01 natural sciences ,010104 statistics & probability ,03 medical and health sciences ,Influenza A Virus, H1N1 Subtype ,0302 clinical medicine ,Intensive care ,Influenza, Human ,Health care ,medicine ,Influenza A virus ,Humans ,030212 general & internal medicine ,A(H1N1) ,0101 mathematics ,Intensive care medicine ,Netherlands ,Retrospective Studies ,Estimation ,business.industry ,Incidence (epidemiology) ,Public health ,Estimation techniques ,medicine.disease ,Influenza ,3. Good health ,Hospitalization ,Infectious Diseases ,Disease Notification ,Medical emergency ,business ,CRITICALLY-ILL PATIENTS ,Algorithms - Abstract
During emerging epidemics of infectious diseases, it is vital to have up-to-date information on epidemic trends, such as incidence or health care demand, because hospitals and intensive care units have limited excess capacity. However, real-time tracking of epidemics is difficult, because of the inherent delay between onset of symptoms or hospitalizations, and reporting. We propose a robust algorithm to correct for reporting delays, using the observed distribution of reporting delays. We apply the algorithm to pandemic influenza A/H1N1 2009 hospitalizations as reported in the Netherlands. We show that the proposed algorithm is able to provide unbiased predictions of the actual number of hospitalizations in real-time during the ascent and descent of the epidemic. The real-time predictions of admissions are useful to adjust planning in hospitals to avoid exceeding their capacity.
- Published
- 2011
- Full Text
- View/download PDF
40. Improved tracing of hepatitis B virus transmission chains by phylogenetic analysis based on C region sequences
- Author
-
W. Marijn van Ballegooijen, Femke D. H. Koedijk, Jeroen Cremer, Eline L.M. Op de Coul, and Hein J. Boot
- Subjects
Male ,Hepatitis B virus ,Sequence analysis ,Sequence Homology ,Biology ,medicine.disease_cause ,Nucleotide diversity ,Phylogenetics ,Virology ,Genotype ,medicine ,Cluster Analysis ,Humans ,Phylogeny ,Netherlands ,Genetics ,Molecular Epidemiology ,Hepatitis B Surface Antigens ,Polymorphism, Genetic ,Phylogenetic tree ,Molecular epidemiology ,Sequence Analysis, DNA ,Hepatitis B ,medicine.disease ,Hepatitis B Core Antigens ,Infectious Diseases ,DNA, Viral ,Female - Abstract
An effective vaccine is available for the hepatitis B virus (HBV), which is a very contagious human pathogen. The prevalence of chronic HBV infection is very low in the Netherlands (
- Published
- 2007
- Full Text
- View/download PDF
41. Emergent trade-offs and selection for outbreak frequency in spatial epidemics
- Author
-
Maarten C. Boerlijst, W. Marijn van Ballegooijen, and Theoretical Ecology (IBED, FNWI)
- Subjects
Molecular Epidemiology ,Multidisciplinary ,Virulence ,Ecology ,Secondary infection ,Trade offs ,Outbreak ,Population biology ,Models, Theoretical ,Biological Sciences ,Biology ,Infections ,Biological Evolution ,Communicable Diseases ,Disease Outbreaks ,law.invention ,Transmission (mechanics) ,law ,Spatial model ,Humans ,Pathogen ,Selection (genetic algorithm) - Abstract
Nonspatial theory on pathogen evolution generally predicts selection for maximal number of secondary infections, constrained only by supposed physiological trade-offs between pathogen infectiousness and virulence. Spread of diseases in human populations can, however, exhibit large scale patterns, underlining the need for spatially explicit approaches to pathogen evolution. Here, we show, in a spatial model where all pathogen traits are allowed to evolve independently, that evolutionary trajectories follow a single relationship between transmission and clearance. This trade-off relation is an emergent system property, as opposed to being a property of pathogen physiology, and maximizes outbreak frequency instead of the number of secondary infections. We conclude that spatial pattern formation in contact networks can act to link infectiousness and clearance during pathogen evolution in the absence of any physiological trade-off. Selection for outbreak frequency offers an explanation for the evolution of pathogens that cause mild but frequent infections.
- Published
- 2004
- Full Text
- View/download PDF
42. Arctic soil development on a series of marine terraces on central Spitsbergen, Svalbard: a combined geochronology, fieldwork and modelling approach
- Author
-
van der Meij, W. Marijn, primary, Temme, Arnaud J. A. M., additional, de Kleijn, Christian M. F. J. J., additional, Reimann, Tony, additional, Heuvelink, Gerard B. M., additional, Zwoliński, Zbigniew, additional, Rachlewicz, Grzegorz, additional, Rymer, Krzysztof, additional, and Sommer, Michael, additional
- Published
- 2016
- Full Text
- View/download PDF
43. Molecular sequence data of hepatitis B virus and genetic diversity after vaccination
- Author
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Hein J. Boot, Roel A. Coutinho, Jacco Wallinga, Sylvia M. Bruisten, Robin van Houdt, W. Marijn van Ballegooijen, Amsterdam institute for Infection and Immunity, Medical Microbiology and Infection Prevention, and Infectious diseases
- Subjects
Hepatitis B virus ,Communicable disease ,biology ,Epidemiology ,business.industry ,Hepatitis B ,medicine.disease_cause ,medicine.disease ,biology.organism_classification ,Men who have sex with men ,Vaccination ,Orthohepadnavirus ,Infectious disease (medical specialty) ,Immunology ,medicine ,Viral disease ,business - Abstract
The effect of vaccination programs on transmission of infectious disease is usually assessed by monitoring programs that rely on notifications of symptomatic illness. For monitoring of infectious diseases with a high proportion of asymptomatic cases or a low reporting rate, molecular sequence data combined with modern coalescent-based techniques offer a complementary tool to assess transmission. Here, the authors investigate the added value of using viral sequence data to monitor a vaccination program that was started in 1998 and was targeted against hepatitis B virus in men who have sex with men in Amsterdam, the Netherlands. The incidence in this target group, as estimated from the notifications of acute infections with hepatitis B virus, was low; therefore, there was insufficient power to show a significant change in incidence. In contrast, the genetic diversity, as estimated from the viral sequence collected from the target group, revealed a marked decrease after vaccination was introduced. Taken together, the findings suggest that introduction of vaccination coincided with a change in the target group toward behavior with a higher risk of infection. The authors argue that molecular sequence data provide a powerful additional monitoring instrument, next to conventional case registration, for assessing the impact of vaccination.
- Published
- 2009
44. Van Ballegooijen et al. Respond to 'Evaluating Vaccination Programs Using Genetic Sequence Data'
- Author
-
Hein J. Boot, W. Marijn van Ballegooijen, Robin van Houdt, Jacco Wallinga, Sylvia M. Bruisten, Roel A. Coutinho, Amsterdam institute for Infection and Immunity, Medical Microbiology and Infection Prevention, and Infectious diseases
- Subjects
Vaccination ,Data sequences ,Epidemiology ,Immunology ,Computational biology ,Biology - Published
- 2009
- Full Text
- View/download PDF
45. Relating Phylogenetic Trees to Transmission Trees of Infectious Disease Outbreaks
- Author
-
Ypma, Rolf J F, primary, van Ballegooijen, W Marijn, additional, and Wallinga, Jacco, additional
- Published
- 2013
- Full Text
- View/download PDF
46. Finding Evidence for Local Transmission of Contagious Disease in Molecular Epidemiological Datasets
- Author
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Ypma, Rolf J. F., primary, Donker, Tjibbe, additional, van Ballegooijen, W. Marijn, additional, and Wallinga, Jacco, additional
- Published
- 2013
- Full Text
- View/download PDF
47. Genetic Data Provide Evidence for Wind-Mediated Transmission of Highly Pathogenic Avian Influenza
- Author
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Ypma, Rolf J.F., primary, Jonges, Marcel, additional, Bataille, Arnaud, additional, Stegeman, Arjan, additional, Koch, Guus, additional, van Boven, Michiel, additional, Koopmans, Marion, additional, van Ballegooijen, W. Marijn, additional, and Wallinga, Jacco, additional
- Published
- 2012
- Full Text
- View/download PDF
48. Different transmission patterns in the early stages of the influenza A(H1N1)v pandemic: A comparative analysis of 12 European countries
- Author
-
Flasche, Stefan, primary, Hens, Niel, additional, Boëlle, Pierre-Yves, additional, Mossong, Joël, additional, van Ballegooijen, W. Marijn, additional, Nunes, Baltazar, additional, Rizzo, Caterina, additional, Popovici, Florin, additional, Santa-Olalla, Patricia, additional, Hrubá, Frantiska, additional, Parmakova, Kremena, additional, Baguelin, Marc, additional, van Hoek, Albert Jan, additional, Desenclos, Jean-Claude, additional, Bernillon, Pascale, additional, Cámara, Amparro Larrauri, additional, Wallinga, Jacco, additional, Asikainen, Tommi, additional, White, Peter J., additional, and Edmunds, W. John, additional
- Published
- 2011
- Full Text
- View/download PDF
49. Improved tracing of hepatitis B virus transmission chains by phylogenetic analysis based on C region sequences
- Author
-
Boot, Hein J., primary, Cremer, Jeroen, additional, Koedijk, Femke D.H., additional, van Ballegooijen, W. Marijn, additional, and Op de Coul, Eline L.M., additional
- Published
- 2007
- Full Text
- View/download PDF
50. Is population-level perversity a likely outcome of mass vaccination against HIV?
- Author
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Bogaards, Johannes A, primary, van Ballegooijen, W Marijn, additional, Jan Weverling, Gerrit, additional, Boerlijst, Maarten C, additional, and Goudsmit, Jaap, additional
- Published
- 2005
- Full Text
- View/download PDF
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