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23 results on '"W. J. F. van der Vijgh"'

2. Abstracts of papers

Author

P. A. v. d. Wouw, H. H. v. Rooy, R. W. Koster, A. J. Porsius, R. G. A. van Wayjen, A. van den Ende, R. G. L. van Tol, T. R. MacGregor, J. Mooy, B. c. Arends, R. Böhm, J. v. Kemenade, M. v. Baak, K. H. Rahn, P. P. Koopmans, Th. Thien, C. M. C. Thomas, F. W. J. Gribnau, J. G. Timmer, A. Vyth, W. Th. Kok, J. M. B. V. de Jong, W. A. den Hartog Jager, J. W. P. M. Overdiek, F. H. H. M. Merkus, M. A. van Bàak, D. de Ryckc, O. Teirlynck, M. G. Bogaert, P. Smits, A. van 't Laar, B. A. M. van Schaik, G. G. Geyskes, J. C. Roos, E. J. Dorhout Mees, G. J. Navis, P. E. de Jong, A. J. M. Donker, G. K. v. d. Hem, D. de Zeeuw, A. H. van den Meiracker, A. J. Man in't Veld, C. J. R. Ritsema, null van Eck, F. H. M. Derkx, M. A. D. H. Schalekamp, J. H. M. Berkelmans, H. Wollersheim, A. C. Dullemond-Westland, J. P. Neijt, J. W. R. Nortier, J. M. A. Sitsen, P. Vermeij, P. M. Edelbroek, M. D. Ferrari, O. J. S. Buruma, F. A. de Wolff, F. Elferink, W. J. F. van der Vijgh, I. Klein, W. W. ten Bokkel Huinink, H. M. Pinedo, M. Raghoebar, H. L. G. M. Tiemessen, P. L. C. M. van Kiel, W. B. van den Berg, and C. A. M. van Ginneken

Subjects
Pharmacology, Pharmaceutical Science, Pharmacology (medical), Pharmacy, General Medicine, Toxicology
Published
1993
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3. Sensitive Determination of Cisplatin in Body Fluids with HPLC and On-Line Reductive Electrochemical Detection

Author

J. de Jong, W. J. F. Van Der Vijgh, O. R. Leeuwenkamp, and M. Treskes

Subjects
inorganic chemicals, Detection limit, Column chromatography, Chromatography, Adsorption, Ion exchange, Chemistry, Molecular Medicine, Reversed-phase chromatography, Dropping mercury electrode, High-performance liquid chromatography, Quantitative analysis (chemistry)
Abstract

A sensitive method for the determination of the antitumor agent cisplatin has been developed consisting of solvent-generated anion exchange chromatography and on-line reductive electrochemical detection. CDDP was retained on a hexadecyl-trimethylammonium-loaded reversed phase HPLC column using a 5mM citrate-buffered eluent (pH 6.5). Exploiting adsorption of CDDP at a dropping mercury electrode and NH4+-enhanced catalytic proton reduction, a detection limit of 10−8 M (3 ng/ml) has been achieved. Application of the developed method to the quantification of CDDP in plasma ultrafiltrate and urine is demonstrated and discussed.

Published
1990
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4. Improved 32P-postlabelling assay for the quantification of the major platinum-DNA adducts

Author

Boudewijn J.M. Braakhuis, M. J. P. Welters, Robert A. Baan, A. J. Jacobs-Bergmans, A.M.J. Fichtinger-Schepman, J. Ma, M. Maliepaard, Jan H.M. Schellens, W. J. F. Van Der Vijgh, and VU University medical center

Subjects
Cancer Research, Antineoplastic Agents, Enzyme-Linked Immunosorbent Assay, High-performance liquid chromatography, Adduct, chemistry.chemical_compound, DNA Adducts, Mice, medicine, Tumor Cells, Cultured, Animals, Humans, Chromatography, High Pressure Liquid, Cisplatin, Chromatography, biology, Chemistry, General Medicine, DNA, In vitro, Biochemistry, Nucleic acid, biology.protein, Chromatography, Thin Layer, Antibody, Quantitative analysis (chemistry), Phosphorus Radioisotopes, medicine.drug
Abstract

For the improvement of chemotherapy with platinum (Pt)-containing drugs a sensitive assay to detect the induced Pt-DNA adducts is needed. Therefore, the 32P-postlabelling assay, described by Blommaert and Saris (Nucleic Acids Res., 1995, 23, 1300-1306), to detect the major adducts Pt-GG and Pt-AG has substantially been improved and compared with ELISA and AAS. For the quantification of the adducts, TpT was added as an internal standard immediately after isolation of the Pt-adducts from digested DNA samples. It was found that 32P-labelling of both GpG and ApG, the dinucleotides obtained after deplatination of the adducts, was equally efficient as that of TpT. To isolate the Pt-adducts on basis of a positive charge, the pH of DNA digests was adjusted to approximately 3 prior to separation by strong cation-exchange chromatography. For the subsequent deplatination a volume of only 12 microl of 0.2 M NaCN was used, which did not interfere with the following labelling step. The quantification of the 32P-labelled dinucleotides was performed by phosphorimaging of spots after separation on TLC as well as by 32P-counting of fractions collected after separation by HPLC. The method was used to determine adduct levels in in vitro cisplatin-treated DNA and in DNA isolated from cisplatin-treated cultured cells, tumor xenografts from cisplatin-treated mice, and from white blood cells and (tumor) tissues from cisplatin-treated patients. The results show a significant correlation with the adduct levels as determined with atomic absorption spectroscopy (high levels) or with specific antibodies (low levels). This assay appears to be useful for the determination of low levels of Pt-adducts in small DNA samples as present in clinical specimens such as blood and tumor tissue, but also in buccal mucosal cells and fine needle aspirates.

Published
1997
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6. Reduced Bioavailability of Digoxin by Magnesium Perhydrol

Author

W. J. F. van der Vijgh, J. H. Fast, and J. E. Lunde

Subjects
Digoxin, Magnesium, medicine.medical_treatment, digestive, oral, and skin physiology, chemistry.chemical_element, Pharmacology, 030226 pharmacology & pharmacy, Bioavailability, carbohydrates (lipids), 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, chemistry, Antacid, 030220 oncology & carcinogenesis, polycyclic compounds, medicine, Pharmacology (medical), cardiovascular diseases, General Pharmacology, Toxicology and Pharmaceutics, Hydrogen peroxide, circulatory and respiratory physiology, medicine.drug
Abstract

A patient who exhibited decreased bioavailability of digoxin during simultaneous administration of the antacid magnesium perhydrol is described. It was shown that digoxin is decomposed by hydrogen peroxide which is liberated from magnesium perhydrol by gastric juice. Therefore, simultaneous administration of digoxin and magnesium perhydrol must be avoided.

Published
1976
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7. Abstracts of papers

Author

D. M. Barends, H. Lingeman, W. van der Doelen, W. M. J. Beek, H. J. Keukens, M. M. L. Aerts, J. H. Beijnen, R. J. Driebergen, T. J. M. Hodes, J. J. M. Holthuis, D. N. Reinhoudt, W. J. M. Underberg, A. Dams, G. de Groot, D. J. de Wildt, J. J. M. Lansemeyer, B. Sangster, L. Delbressine, M. Moonen, M. v. Oosterhout, G. Wagenaars, F. Kaspersen, M. De Smet, S. Van Belle, C. Storme, D. L. Massart, H. A. J. de Waal, J. C. Kraak, F. J. M. J. Haessen, S. M. Dreijer-van der Glas, A. Bult, B. F. H. Drenth, K. J. Hellingwerf, J. den Hartigh, J. S. Blauw, J. H. Beljnen, W. J. van Oort, S. J. Postma, W. Verboom, P. Lelieveid, R. H. Drost, R. D. van Ooijen, T. I. Ionescu, J. M. van Rossum, R. A. A. Maes, F. Elferink, W. J. F. van der Vijgh, I. Klein, H. M. Pinedo, N. Haagsma, B. Dieleman, B. G. M. Gortemaker, C. van de Water, M. J. B. Mengelers, C. Schreuder, A. Hulshoff, P. L. Jacobs, G. J. H. Scnmeits, H. Nieuwenhuyse, J. Vink, H. Jansen, E. G. van der Velde, U. A. Th. Brinkman, R. W. Frei, H. Veening, W. Th. Kok, W. H. Voogt, P. H. Kuijpers, J. Zeeman, G. J. de Jong, G. Musch, Frits A. J. Muskiet, N. M. M. Nibbering, H. J. E. M. Reeuwijk, U. R. Tjaden, L. G. C. Spanjers, J. P. de Kleijn, H. C. Kerkdijk, Gerrit L. M. van de Laar, Jan E. Paanakker, O. A. G. J. van der Houwen, J. Teeuwsen, J. v. Gorp, P. Salemink, M. Vermeulen, L. Kolkman, G. W. Welling, R. van der Zee, S. Wellinq-Wester, and J. van der Greef

Subjects
Pharmacology, Degradation kinetics, Chemistry, Pharmacology (medical), Photochemistry
Published
1985
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8. Abstracts of papers Clinical Pharmacological meeting

Author

J. J. M. van Meyel, P. Smits, F. W. J. Gribnau, L. H. A. B. Van Bortel, T. van Herode, F. A. H. Smeets, R. S. Reneman, H. A. J. Struyker Boudler, W. Aengevaeren, F. Corstens, T. v. d. Werf, Th. Thien, J -P. H. C. Buijsrogge, Th Thien, P. M. Hooymans, M. J. Pouwels, G. C. H. M. v. d. Aa, M. J. Pouwbls, J. M. W. J. Diepstraten, P. P. Koopmans, G. C. H. M. van der Aa, O. R. Leeuwenkamp, H. E. Van Per Wiel, W. J. F. van der Vijgh, H. Greuter, R. Barto, J. C. Netelenbos, P. Lips, D. de Vos, P. H. Th. J. Siee, D. Stevenson, P. de Vos, P. H. Th. J. Slee, B. Ooslerhuis, G. Nehmiz, P. J. G. Cornelissen, P. B. M. Zuiderwijk, H. J. Jeuring, J. H. G. Jonkman, C. A. P. F. Su, R. G. L. van Tol, A. van Riel, A. L. H. Kerremans, C. K. van Kalken, J. de Jong, J. J. M. van der Hoeven, H. M. Pinedo, C. Kroon, A. de Boer, F. J. M. van der Meer, P. M. Edelbroek, H. C. Schoemaker, A. F. Cohen, A. L. van Steveninck, J. M. Kroon, M. S. M. Pieters, D. D. Breimer, J. J. Tukker, and A. J. M. Mculendijk

Subjects
Pharmacology, Pharmacology (medical)
Published
1989
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9. Abstracts of papers

Author

H. Wesseling, E. v. d. Veur, B. S. ten Berge, A. J. M. Donker, J. F. May, F. H. Schuurman, B. A. M. van Schaik, G. G. Geyskes, H. Petri, R. Böhm, J. Mooy, J. van Kemenade, M. van Baak, K. H. Rahn, H. A. E. M. van Heereveld, H. Wollersheim, Th. Thien, J. W. J. Lammers, H. Th. M. Folgering, C. L. A. van Herwaarden, S. J. Graafsma, P. J. F. Snijders, J. F. Rodrigues de Miranda, E. A. de Bruijn, A. T. van Oosterom, P. J. K. Kuppen, C. Jol, U. R. Tjaden, J. B. Trimbos, E. A. Runhaar, H. A. Nooij, A. A. J. van de Loo, P. A. J. Speth, P. C. M. Linssen, C. Haanen, O. R. Leeuwenkamp, J. H. Neyt, W. J. F. van der Vijgh, H. M. Pinedo, J. H. M. Schellens, M. Danhof, D. D. Breimer, J. W. P. M. Overdiek, F. W. H. M. Merkus, H. W. A. Teeuwen, P. de Schepper, T. B. Tjandramaga, J. M. van Rossum, J. J. Tukker, M. A. Blankenstein, J. W. R. Nortier, F. A. Zantvoort, J. H. T. Wagonvoort, F. H. M. Derkx, M. F. Michel, W. J. A. Wijnands, A. M. Baars, T. B. Vree, R. van Dalen, E. S. F. Termond, P. Boekema, P. Smits, R. de Abreu, Th. Thlen, A. van 't Laar, R. O. B. Böhm, B. G. Arends, H. E. J. van Hooff, M. A. van Baak, F. Derkx, H. Tan-Tjiong, G. Wenting, A. Manin't Veld, M. Schalekamp, J. van Harten, P. van Brummelen, H. Danhof, M. Th. M. Lodewijks, P. A. F. Jansen, C. A. M. van Ginneken, F. W. J. Gribnau, J. J. H. M. Lohman, P. M. Hooymans, F. W. H. H. Merkus, M. J. T. M. Mol, A. F. H. Stalenhoef, P. N. M. Demacker, A. van't Laar, J. A. M. Raaijmakers, G. K. Terpstra, and R. S. G. Holdrinet

Subjects
Pharmacology, Pharmacology (medical)
Published
1986
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10. Abstracts of lectures symposium disposition and delivery of peptide drugs

Author

H. M. Pinedo, Rokus A. de Zeeuw, E. A. Hogendoorn, R. van Gijn, S. V. Rose, M. Barnard, H. H. van den Broek, O. A. G. J. van der Houwen, H. M. Ruijten, P. De Moerloose, M. A. J. van Opstal, A. J. Baars, A. Bult, L. G. D. Lammerts van Bueren, K. Ensing, E. v.d. Heeft, J. H. G. Jonkman, W. P. van Bennekom, L. P. C. P. Delbressine, R. W. Frei, H. J. van Rossum, W. G. in 't Hout, C. van de Water, J. J. M. de Clippeleir, Ben F. H. Drenth, K. Sierat, U. A. Th. Brinkman, N. Haagsma, G. de Groot, Naeem Hasan Khan, E. H. Groot Bramel, D. J. K. van der Stel, C. P. Groen, W. J. M. Underberg, P. S. L. Janssen, D. E. M. M. Vendrig, J. A. De Schutter, P. A. Maessen, M. J. M. v. Zeeland, A. Mekking, P. J. M. Kwakman, J. H. N. van den Berg, A. L. L. Duchateau, J. K. van den Bergh-Swart, H. Vanderhaeghe, P. A. T. A. Melgers, M. W. Lobbezoo, C. E. Goewie, H. de Bree, N. G. F. M. Lammers, H. M. Steinbuch, P. W. Zoontjes, R.A. de Zeeuw, B. C. Goverde, J. Hempenius, A. S. Horn, D. A. Bloemhof, E. Roets, O. A. M. Brockhoff, R. L. A. E. Hanmelinck, M. Otagiri, P. M. J. Coenegracht, D. A. Doornbos, F. J. Spruit, T. K. Gerding, Th. Cachet, O. E. de Noord, Karla G. Feitsma, S. C. M. Lubbers, H. van Blitterswijk, O. R. Leeuwenkamp, R. W. Stephany, M. P. van Berkel, S. L. Verweij, G. J. de Jong, B. F. H. Drenth, W. J. F. van der Vijgh, P. Krabbenborg, J.M. van den Berg, H. van Beek, O. Beckers, A. C. A. Paalman, F. M. Kaspersen, W. J. F. vd Vijh, N. Lammers, L. A. van Ginkel, J. Hoogmartens, P. J. H. Hendricks, K. B. Mross, T. A. Verstappen, J. Teeuwsen, J. J. M. Holthuis, J. Tipker, G. W. M. v. Aalst, P. R. Kootstra, J. W. v. Nispen, Jos H. Beijnen, F. Elferink, B. C. A. Tepas, A. Blokland, and A. J. P. M. de Jong

Subjects
Pharmacology, chemistry.chemical_classification, chemistry, business.industry, Medicine, Pharmacology (medical), Peptide, Disposition, Peptide hormone, business, Peptide drug
Abstract

A number of different processes clear peptides from the circulation. These will be described and illustrated using examples from a range of peptide hormones and analogues.

Published
1988
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11. Abstracts of papers

Author

J. L. Slangen, C. E. Ciurgea, J. Jolles, J. G. C. van Amsterdam, K. J. H. van Buuren, W. Soudijn, J. C. van Oene, J. B. de Vries, D. Dijkstra, R. J. W. Renkema, P. G. Tepper, A. S. Horn, A. Bast, E. M. Savenije-Chapel, B. H. Kroes, H. A. Nugteren, F. H. N. de Haan, J. G. H. Joosten, A. C. A. Jansen, R. E. Koopmans, R. F. Rekker, A. P. Ijzerman, G. Aué, T. Bultsma, H. Timmerman, M. J. Krielaart, M. W. G. von der Schaar, B. Rademaker, J. Zaagsma, C. J. van Koppen, H. L. M. Siero, J. F. Rodrigues de Miranda, A. J. Beld, E. J. Ariëns, H. M. E. Scheres, A. B. M. Klaassen, W. Kuypers, F. T. M. van Amsterdam, G. J. Sterk, H. van der Goot, J. M. S. van Maanen, F. Cobas, C. de Ruiter, J. de Vries, H. M. Pinedo, M. R. Linschoten, H. -D. Gaisser, J. H. M. Dröge, L. H. M. Janssen, J. Wilting, E. L. M. Voorbrood, J. M. H. Kremer, A. Bakri, G. M. J. Beijersbergen van Henegouwen, H. de Vries, F. A. Huf, A. G. J. Sedee, K. J. Lusthof, G. Lodder, N. J. de Mol, R. W. Busker, T. B. Drexler, L. Weeda, J. P. A. C. M. Maanders, R. M. Posthuma, G. R. Mohn, J. F. Plantlé, F. J. Daus, H. A. Hansen, J. C. Stoof, B. Hazelhoff, P. Dijkstra, T. Mulder, F. Elferink, W. J. F. van der Vijgh, J. Brussee, J. M. te Koppele, and J. L. G. Groenendijk

Subjects
Pharmacology, Pharmacology (medical)
Published
1984
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12. Abstracts of papers Pharmaceutical and biomedical analysis meeting

Author

R. Both-Miedema, E. H. J. M. Jansen, H. A. Claessens, P. J. M. Hendriks, M. T. Ackermans, R. W. Sparidans, F. M. Everaerts, G. de Groot, R. Koops, K. L. Wubs, J. de Jong, S. F. Cheung, P. A. Maessen, H. M. Pinedo, W. J. F. van der Vijgh, J. den Hartigh, R. Langebroek, P. Vermeij, L. Doom, F. X. R. van Leeuwen, C. E. M. Heeremans, R. A. M. van der Hoeven, W. M. A. Niessen, U. R. Tjaden, J. van der Greef, J. Hempenius, B. Staal, H. J. Jeuring, C. K. Mensink, J. H. G. Jonkman, H. Hindriks, F. Maris, A. Pasters, M. de Smet, D. Massart, P. S. L. Janssen, R. L. A. E. Hamelinck, P. A. T. A. Melgers, J. W. van Nispen, M. J. M. van Zeeland, M. H. J. M. van de Ven, J. Vink, H. Lambrechts, G. Pattyn, A. T. Van Oosterom, E. A. de Bruijn, O. R. Leeuwenkamp, R. Barto, H. Greuter, P. Lips, J. C. Netelenbos, F. A. Maris, R. J. M. Vervoort, M. B. Vrieling, E. J. M. Reinerink, R. H. van den Berg, E. Roets, L. Aerden, I. Hoogmartens, S. V. Rose, J. P. Crombeen, L. G. D. Lammerts van Bueren, H. Rosing, F. Elferink, F. J. van de Vaart, A. C. Schoots, P. H. J. M. De Vries, T. P. E. M. Verheggen, O. M. Steijger, E. Hoksbergen, R. A. Baumann, J. J. M. Holthuis, U. A. Th. Brinkman, B. Takkenberg, H. E. van Ingen, M. Ackermans, E. Endert, UR Tjaden, HJEM Reeuwijk, A. T. van Oosterom, C. van de Water, N. Haagsma, W. A. van den Ham, A. H. Piersma, L. A. van Ginkel, R. W. Stephany, J. C. M. Farla, H. J. van Rossum, R. van Gijn, J. H. Beijnen, J. J. M. de Clippeleir, S. Horenblas, W. J. M. Underberg, O. van Tellingen, J. H. Beilnen, H. R. van der Woude, W. J. Nooven, K. van Twillert, P. W. M. Zeijlmans, M. Olling, H. G. J. M. Derks, Weng Naidong, Th. Cachet, J. Hoogmartens, J. Wieling, P. M. J. Coencgracht, D. A. Doornbos, and G. Windhorst

Subjects
Pharmacology, medicine.medical_specialty, Medical education, business.industry, Political science, Public health, medicine, Pharmacology (medical), Pharmacy, business
Published
1989
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13. Highly sensitive differential pulse amperometric detection of second generation anti-tumor platinum compounds in HPLC effluents

Author

G. J. Postma, H. B. J. van der Lee, W. J. F. van der Vijgh, and H.M. Pinedo

Subjects
Detection limit, Polarography, Chromatography, Aqueous solution, Chemistry, Organic Chemistry, Clinical Biochemistry, Platinum compounds, Biochemistry, Chloride, High-performance liquid chromatography, Amperometry, Analytical Chemistry, medicine, Effluent, medicine.drug
Abstract

A highly sensitive on-line amperometric detection of platinum compounds in HPLC effluents was possible with the use of a polarographic detector. For TNO-1 (=cis-1,1-di(aminomethyl)-cyclohexane Pt(II)chloride) a linear dynamic range of at least three decades could be obtained (0.034–108μg TNO-1/ml) with a detection limit of three times the noise signal at 0.7 ng TNO-1 (20ng Pt/ml). The sensitivity was 0.1 nA/ng TNO-1 (0.2nA/ng Pt). The within-day presicion was 1.1% at a concentration of 10.8μg TNO-1/ml (n=10). With this system the compatibility was measured of TNO-6 with infusion fluids. In 0.15 M NaCl, TNO-6 (=cis-1,1-di(aminomethyl)-cyclohexanePt(II)sulphate) was converted into TNO-1 within 40 minutes. Molecular changes of TNO-6 were also observed in a 5% aqueous glucose solution.

Published
1983
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14. Abstracts of papers symposium disposition and delivery of peptide drugs

Author

M. Barnard, J. H. Beijnen, S. C. M. Lubbers, O. A. G. J. van der Houwen, M. W. Lobbezoo, W. J. M. Underberg, Th. Cachet, E. Roets, J. Hoogmartens, H. Vanderhaeghe, H. de Bree, D. J. K. van der Stel, O. A. M. Brockhoff, M. P. van Berkel, K. Sierat, G. de Groot, B. C. A. Tepas, O. E. de Noord, J. Hempenius, P. M. J. Coenegracht, J. H. G. Jonkman, D. A. Doornbos, J. A. De Schutter, P. De Moerloose, L. P. C. P. Delbressine, F. M. Kaspersen, A. Blokland, A. L. L. Duchateau, T. A. Verstappen, P. J. H. Hendricks, F. Elferink, O. R. Leeuwenkamp, H. M. Pinedo, W. J. F. vd Vijh, K. Ensing, D. A. Bloemhof, W. G. in 't Hout, R. A. de Zeeuw, Karla G. Feitsma, Ben F. H. Drenth, Rokus A. de Zeeuw, T. K. Gerding, B. F. H. Drenth, A. S. Horn, C. P. Groen, J. Tipker, J. K. van den Bergh-Swart, F. J. Spruit, J. H. N. van den Berg, E. H. Groot Bramel, O. Beckers, M. Otagiri, P. S. L. Janssen, J. W. v. Nispen, P. A. T. A. Melgers, M. J. M. v. Zeeland, R. L. A. E. Hanmelinck, B. C. Goverde, G. W. M. v. Aalst, P. R. Kootstra, H. H. van den Broek, E. A. Hogendoorn, C. E. Goewie, P. J. M. Kwakman, U. A. Th. Brinkman, R. W. Frei, G. J. de Jong, N. G. F. M. Lammers, J. H. M. van den Berg, N. Lammers, H. M. Ruijten, P. A. Maessen, K. B. Mross, W. J. F. van der Vijgh, Naeem Hasan Khan, S. V. Rose, L. G. D. Lammerts van Bueren, H. van Beek, A. J. Baars, L. A. van Ginkel, H. M. Steinbuch, H. J. van Rossum, H. van Blitterswijk, P. W. Zoontjes, E. v.d. Heeft, A. J. P. M. de Jong, R. W. Stephany, R. van Gijn, J. J. M. de Clippeleir, S. L. Verweij, A. C. A. Paalman, M. A. J. van Opstal, P. Krabbenborg, J. J. M. Holthuis, W. P. van Bennekom, A. Bult, C. van de Water, N. Haagsma, D. E. M. M. Vendrig, A. Mekking, and J. Teeuwsen

Subjects
Pharmacology, Pharmacology (medical)
Published
1988
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15. Abstracts of papers

Author

W. J. van Oort, J. J. M. Holthuis, E. J. de Vries, J. B. G. M. Noten, A. P. Labruyère, U. A. Th Brinkman, H. A. H. Billiet, C. J. C. M. Laurent, L. de Galan, A. Hulshoff, K. Ensing, R. A. de Zeeuw, O. R. Leeuwenkamp, E. J. van der Mark, H. Jousma, W. P. van Bennekom, A. Bult, W. Onkenhout, E. J. C. van Bergen, J. H. F. van der Wart, N. P. E. Vermeulen, P. van der Klauw, B. Oosterhuis, J. C. F. M. Wetsteyn, C. J. van Boxtel, A. Klok, G. R. Kornblum, E. F. Vogelaar, W. Th Kok, R. W. Frei, H. de Bree, P. H. van Amsterdam, D. J. K. van der Stel, M. Th M. Tulp, W. R. Vincent, L. W. de Zoeten, H. M. Ruyten, M. P. van Berkel, R. M. Bergsma, P. Bouma, D. R. A. Uges, H. J. Kolstee, H. Bloemhof, T. B. Vree, M. W. Tijhuis, J. F. M. Nouws, Y. A. Hekster, D. H. Barends, J. S. Blauw, C. J. L. R. Govers, O. A. G. J. van der Houwen, A. W. M. Indemans, H. Lingeman, W. J. M. Underberg, J. Renema, D. E. M. Vendrig, O. A. Lake, W. J. M Underberg, J. Wilting, J. H. Beijnen, J. den Hartigh, P. R. Kootstra, C. de Ruiter, J. de Vries, C. Gooijer, C. Funke, E. van Doornum, L. van Dijck, M. van Leuken, R. van Hattem, C. van der Ven, F. Elferink, W. J. F. van der Vijgh, H. M. Pinedo, M. J. M. Jongen, J. C. Netelenbos, P. Lips, H. J. G. Debets, J. W. Weyland, and P. A. Doornbos

Subjects
Pharmacology, Pharmacology (medical)
Published
1983
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16. Abstracts of papers

Author

B. A. H. van Schaik, A. E. J. van Nistelrooy, G. G. Geyskes, P. P. Koopmans, Th Thien, F. W. J. Gribnau, F. H. M. Derkx, A. J. Man in 't Veld, M. A. D. H. Schalekamp, H. Peters, J. W. M. Lenders, W. J. de Goede, P. Vermeij, J. H. Hulshof, R. A. M. van Langeveld, B. F. M. Pluym, P. M. Hooymans, H. A. G. van der Pol, J. J. H. M. Lohman, M. Danhof, Y. A. Hekster, T. B. Vree, D. Overbosch, H. Mattie, A. M. Horrevorts, J. E. Degener, G. Dzoljic-Danilovic, M. F. Michel, K. F. Kerrebijn, O. M. J. Driessen, J. Hermans, F. A. de Wolff, E. J. M. de Haas, R. A. C. Roos, A. G. de Boer, L. G. J. de Leede, D. D. Breimer, F. Elferink, W. J. F. van der Vijgh, J. B. Vermorken, G. J. Postma, I. Klein, H. M. Pinedo, F. M. P. Lindelauf, M. J. A. M. Franssen, Y. Tan, C. A. M. van Ginneken, and L. B. A. v.d.Putte

Subjects
Pharmacology, Pharmacology (medical)
Published
1983
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17. Abstracts of papers Medicinal chemistry meeting

Author

M. G. Darlison, A. N. Bateson, R. J. Harvey, W. Wisden, E. A. Barnard, H. Loosfelt, M. Atger, A. Gulochon-Mantel, M. Misrahi, M. Perrot-Applanat, M. T. Vu Hai, F. Lorenzo, E. Milgrom, Chris J. van Koppen, Neil M. Nathanson, J. D. Naber, J. J. S. van Rensen, A. Baarslag, L. Koymans, G. M. Donné -Op den Keider, N. P. E. Vermeiden, P. P. Kelder, N. J. de Mol, L. A. 't Han, L. H. M. Janssen, S. P. van Helden, H. W. Hilbers, M. J. van Prooge, A. C. A. Jansen, L. H. M. Jansen, Anja Garritsen, Ad P. Jzerman, Margot W. Beukers, Willem Soudijn, LAGM vd Brock, Z. Zylicz, H. Hofs, D. J. Th. Wagener, J. P. G. Ballesta, P. Lelieveld, HCJ Ottenheijm, I. den Daas, P. G. Tepper, D. I. Mastebroek-Helder, A. S. Horn, W. Timmerman, B. G. J. Bohus, Durk Dijkstra, Swier Copinga, Jan B. de Vries, Sjaak den Daas, Alan S. Horn, P. N. Span, B. G. Quik, K. J. H. van Buuren, D. M. J. Veenstra, S. C. M. Levering, B. Rademaker, C. G. Huisman, M. de Boer, E. E. Moret, J. J. M. Holthuis, R. J. Driebergen, P. N. Reinhoudt, W. Verboom, A. A. van Til, F. B. van Duijneveldt, W. Vleeming, A. Stam, E. P. Bleuel, H. H. van Roolj, J. Wemer, A. J. Porsius, J. Riezebos, D. J. de Wildt, W. Vieeming, H. H. van Rooij, J. de Jong, P. R. Schopfs, R. C. A. Onderwater, H. M. Pinedo, W. J. F. van der Vijgh, A. Bast, J. F. de Vlieger, C. I. A. Doelman, M. M. Brozius, R. Leurs, H. Timmerman, M. J. Smit, A. van der Vliet, Marcel A. H. de Zwart, Henricus M. M. Bastianns, Deborah Brouwer, Henk van der Goot, Hendrik Timmerman, S. Ciere, G. R. M. M. Haenen, J. Ch. Eriks, S. A. van Acker, L. Kovmans, G. M. Donné -Op den Kelder, N. P. E. Vermeulcn, A. R. Goeptar, J. M. te Koppele, N. P. E. Vermeulen, E. P. A. Neve, G. J. Stijnties, J. M. te Koppete, N. P. F. Vermeulen, I. M. Pirovano, A. P. Ijzerman, A. M. van Rhee, W. Soudijn, C. J. Witmans, C. J. Grol, W. G. J. HoL, C. Verlinde, and F. R. Opperdoes

Subjects
Pharmacology, Pharmacology (medical)
Published
1989
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18. Abstracts of papers

Author

W. J. van Oort, B. Kerkhofs, A. van Dijk, O. A. G. J. van der Houwen, A. Hulshoff, A. W. M. Indemans, J. C. Reijenga, A. Gaykema, F. E. P. Mikkers, O. R. Leeuwenkamp, H. Jousma, E. J. van der Mark, A. Bult, W. van Iersel, B. F. H. Drenth, R. T. Ghijsen, R. A. de Zeeuw, J. J. M. Holthuis, A. W. Sijstermans, F. M. G. M. Römkens, E. B. C. M. Weller, H. M. Pinedo, J. G. McVie, P. M. Barends, M. H. Smits, J. S. Blauw, J. den Hartigh, R. J. Driebergen, J. E. M. A. Schijns, W. J. M. Underberg, O. A. Lake, H. Lingeman, U. K. Underberg-Chitoe, J. Wilting, T. Jagersma, J. C. Hoogvliet, F. Elferink, A. C. J. Hermans-Lokkerbol, W. P. van Bennekom, C. E. Werkhoven-Goewie, C. de Ruiter, U. A. Th. Brinkman, R. W. Frei, G. de Vries, J. F. van de Calseyde, J. van der Veeken, Th. P. E. M. Verheggen, F. M. Everaerts, W. J. F. van der Vijgh, H. B. J. van der Lee, G. J. Postma, Tom B. Vree, Chiel A. Hekster, Marijn M. J. Oosterbaan, Emiel F. S. Termond, A. C. Schoots, C. A. Cramers, H. Poppe, F. J. van de Vaart, H. A. Claessens, M. van Thiel, P. Westra, J. J. M. Labout, and A. P. Bruins

Subjects
Pharmacology, Pharmacology (medical)
Published
1982
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19. Development of macromolecular prodrugs of the antitumor antibiotic adriamycin

Author

H.M. Pinedo, W.A.R. Heeswijk, M.J.D. Eenink, Jan Feijen, C.J.T. Hoes, P. Lelieveld, T. Stoffer, J. van der Poort, W. J. F. van der Vijgh, W. Potman, Faculty of Science and Technology, and Biomaterials Science and Technology

Subjects
Macromolecular prodrugs, Chemistry, medicine.drug_class, Antibiotics, Polymer chemistry, medicine, Combinatorial chemistry
Published
1985
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20. Synthesis, Characterization and Antitumor Activity of Macromolecular Prodrugs of Adriamycin

Author

M.J.D. Eenink, W. A. R. van Heeswijk, W. Potman, J. v.d. Poort, W. J. F. van der Vijgh, H.M. Pinedo, P. Lelieveld, Jan Feijen, and T. Stoffer

Subjects
chemistry.chemical_classification, Pathogenesis, Metabolic pathway, Cardiotoxicity, chemistry.chemical_compound, chemistry, Toxicity, Polyglutamic acid, Microsome, Myocyte, Pharmacology, Divalent
Abstract

The anthracycline antibiotics daunomycin and 14-hydroxydaunomycin (adriamycin) have been shown to be very effective in the treatment of a number of malignancies (1). Besides the non-specific side-effects of cytostatic agents, adriamycin exerts a specific toxic activity on the heart (2). This side effect may eventually lead to a life-threatening congestive heart failure when a cumulative dose of 550 mg.m-2 has been exceeded. Although the exact mechanism through which toxicity develops has not been elucidated, three major hypotheses on the pathogenesis of adriamycin induced cardiotoxicity have been postulated. As all quinones, adriamycin is a potent chelating agent for divalent cations, in particular for Ca2+ which is involved in the excitation-contraction coupling of muscle cells (3). Adriamycin can be converted to a semi-quinone either by microsomal or by mitochondrial metabolic pathways. These semiquinones give rise to the formation of free radicals, which may lead to peroxidation of polyunsaturated fatty acid structures (4). Finally, adriamycin is a strong intercalating agent, which causes an inhibition of RNA, DNA protein synthesis. Inhibition of the synthesis of contractile proteins and of reparative growth (5) will lead to a gradual decline of contractile properties of the heart.

Published
1984
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21. Long-term digoxin treatment in general practice

Author

W J F van der Vijgh

Subjects
medicine.medical_specialty, Digoxin, business.industry, General Engineering, General Medicine, Term (time), General practice, Correspondence, General Earth and Planetary Sciences, Medicine, business, Intensive care medicine, General Environmental Science, medicine.drug
Published
1976

22. Clinical Experience with 1, 1-Diaminomethylcyclohexane (Sulphato) Platinum (II) (TNO-6)

Author

W. W. Bokkel ten Huinink, H.M. Pinedo, Jan B. Vermorken, J. G. McVie, and W. J. F. van der Vijgh

Subjects
Cisplatin, Oncology, medicine.medical_specialty, Chemotherapy, Bladder cancer, business.industry, medicine.medical_treatment, medicine.disease, Nephrotoxicity, Ototoxicity, Internal medicine, medicine, Vomiting, medicine.symptom, business, Ovarian cancer, Testicular cancer, medicine.drug
Abstract

Cis-diamminodichloroplatinum II (cisplatin) is the first member of a group of platinum coordination complexes, which were shown to possess antitumor activity (1). With the introduction of cisplatin into the clinic the spectrum of tumors which can be treated effectively with chemotherapy has broadened (2). This agent is increasingly utilized in first-line regimens against testicular cancer, ovarian cancer, head and neck cancer, bladder cancer, while results in squamous cell cancer of the uterine cervix and in some childhood solid tumors like neuroblastoma and osteogenic sarcoma have been most promising. However, the use of the drug is hampered by some serious side effects. Its major clinical disadvantages are intense nausea and vomiting and renal impairment (3,4). Nausea and vomiting are much more distressing than found with other cytostatic drugs and cannot be effectively prevented. Adequate hydration and attention paid to optimal urinary flow results in a decrease in the incidence and the severity of nephrotoxicity. Nevertheless, substantial decrease in glomerular filtration rate and effective renal plasma flow can be found, which may be at least partially irreversible (5,6). Other toxicities include neurotoxicity, ototoxicity, myelosuppression, diarrhea and occasional liver function test abnormalities, electrolyte imbalances and occasional anaphylactic-like reactions (7). Although nephrotoxicity is generally considered as the major dose limiting toxicity, methods to overcome this toxicity have created the possibility to administer multiple courses of the drug. With prolonged treatment other toxicities may become dose-limiting. Recognition of these limitations has stimulated a widespread search for alternative platinum complexes with equal or greater antitumor activity but with decreased toxicities.

Published
1984
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