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1. Abstracts

Author

Saiah Michèle, Borgeat Alain, Wilder-Smith Oliver, Orlando R. Hung, Charles E. Hope, Geoffrey Laney, Sara C. Whynot, Thomas J. Coonan, David S. Malloy, S. Patterson, A. Gelb, P. Manninen, D. Strum, B. Glosten, M. J. Spellman, E. I. Eger, R. A. Craen, A. W. Gelb, J. M. Murkin, K. Y. Chong, D. H. Penning, H. El-Behairy, J. F. Brien, J. W. Coh, R. Arellano, J. Correa, L. Fedorko, Z. Liu, J. F. Boylan, A. N. Sandler, H. Nierenberg, P. A. Sheiner, P. D. Greig, G. M. O’Leary, S. J. Teasdale, M. F. X. Glynn, B. A. Orser, L. -Y. Wang, J. F. MacDonald, C. W. Loomis, K. D. Arunachalam, D. Vyas, B. Milne, Daniel Gagnon, Josée Lavoie, Jean-Yves Dupuis, D. R. Miller, R. J. Martineau, D. Greenway, L. Olivaris, K. Hull, R. N. M. Tierney, J. E. Wynands, R. Martineau, B. St-Jean, J. Kitts, D. Miller, P. Lindsay, M. Curran, G. C. Allen, M. L. Crossan, Richard Wise, François Donati, David R. Bevan, J. F. Hardy, J. Desroches, J. Perrault, M. Carrier, D. Robitaille, D. M. Ansley, J. P. O’Connor, J. Dolman, G. E. Townsend, D. Ricci, D. J. Liepert, P. M. Browne, T. Hertz, M. Rooney, R. W. Yip, W. Code, A. A. Phillips, R. F. McLean, J. H. Devitt, E. M. Harrington, R. J. Byrick, P. Y. Wong, D. Wigglesworth, J. C. Kay, L. A. Sinclair, J. P. Koch, K. A. Deemar, G. K. Christakis, S. Belo, P. Angle, D. Cheng, J. Boylan, A. Sandler, C. Feindel, F. Carmichael, P. Boylen, L. G. R. DeLima, H. J. Nathan, M. S. Hynes, M. E. Bourke, G. N. Russell, C. Seyone, F. Chung, Daniel Chartrand, Lucie Roux, S. L. Dain, B. D. Smith, A. C. Webster, D. F. Wigglesworth, D. K. Rose, G. Caskennette, C. Mechetuk, D. John Doyle, Wilfred DeMajo, Frank van den Bosch, Mark Lee, K. M. McClenaghan, C. D. Mazer, R. Preston, E. T. Crosby, D. Kotarba, H. Dudas, R. D. Elliott, J. Enns, P. H. Manninen, J. K. Farrar, David L. Huzyka, L. Philip Lin, Susan Fossey, Brendan T. Finucane, M. Stockwell, S. Lozanoff, S. Lang, J. Hyssen, D. C. Campbell, M. J. Douglas, T. J. G. Pavy, M. L. Flanagan, G. H. McMorland, Colin Bands, Ch. B. Ffaracs, Catherine Lipsett, David Drover, Mark Stafford-Smith, Sarah Stevens, Kate Shields, Michael J. MacSween, J. D. McAllister, P. K. Morley-Forster, A. K. White, M. D. Taylor, H. M. Vandenberghe, D. Knoppert, H. Reimer, P. C. Duke, C. H. Kehler, M. W. Kepron, V. A. Taraska, J. Carstoniu, P. Norman, J. Katz, Medhat Hannallah, C. M. Cooney, J. B. Lyons, A. Hennigan, W. P. Blunnie, D. C. Moriarty, W. B. Dobkowski, F. S. Prato, N. A. Shannon, D. J. Drost, B. Arya, J. M. Wills, D. Bond, P. Morley-Forester, Mullen JB, I. Spahr-Schopfer, J. Lerman, E. Cutz, M. Dolovich, S. Kowalski, B. Ong, D. Bell, T. Ostryzniuk, C. Serrette, T. Wasylak, S. Coke, Takako Tsuda, Takashi Nakagawa, Norifumi Mabuchi, Hiroshi Ando, Osamu Nishida, Takafumi Azami, Hirotada Katsuya, Yukio Goto, N. Searle, M. Roy, null R. R. T., Charles E. Smith, Alfred C. Pinchak, Joan F. Hagen, Donald Hancock, Andrei V. Krassioukov, Lynne C. Weaver, I. R. Sutton, W. A. C. Mutch, J. M. Teskey, I. R. Thomson, M. Rosenbloom, D. Thiessen, S. Teasdale, H. Corbin, M. R. Graham, S. A. Lang, P. Chang, M. Gerard, J. E. Tetzlaff, M. Walsh, H. Yoon, Brian Warriner, Peter Fancourt-Smith, Jim McEwen, Judy Crane, N. H. Badner, R. Bhandari, W. E. Komar, S. Ganapathy, C. B. Warriner, J. P. McCormack, M. Levine, N. Glick, V. W. S. Chan, M. McQuestion, M. Gomez, C. Cruise, D. Evana, D. Shumka, R. J. Smyth, M. Graham, David Halpenny, Gerald V. Goresky, J. Eldon Zaretski, B. Kavanagh, S. Roger, A. Davies, M. Friedlander, M. M. Cohen, P. G. Duncan, W. D. B. Pope, D. Biehl, R. Merchant, W. A. Tweed, Michael J. Tessler, Mark Angle, Simcha Kleiman, B. P. Kavanagh, G. J. Doak, G. Li, R. I. Hall, J. A. Sulliyan, I. Yee, S. Halpern, R. Pittini, C. Huh, G. L. Bryson, R. Gverzdys, C. Perreault, L. Ferland, F. Gobeil, D. Girard, R. Smyth, B. Asokumar, M. Glynn, Sandra Silveira, Jeff Clark, Paul Milgram, W. M. Splinter, H. B. MacNeill, E. A. Ménard, E. J. Rhine, D. J. Roberts, G. M. Gould, G. G. Johnson, Daniel Quance, Saul Wiesel, Jane Easdown, N. Tien Truong, Normand Miller, Nathan Sheiner, L. Welborn, J. Norden, R. Hannallah, L. Broadman, N. Seiden, M. Iwai, R. Iwai, H. Horigome, M. Yamashita, Catherine E. Wood, Kim Klassen, S. Kleinman, S. Yentis, N. Sikich, T. A. Yemen, B. Mascik, W. Nelson, H. Ghantous, J. Gandolfi, Gordon Wood, Mohamed Ali, Kevin Inman, J. M. Karski, J. Carroll, D. Brooks, P. A. Oakley, P. M. Webster, J. Karski, T. Yao, J. Ivanov, P. Young, S. Carson, R. D. Weisel, Richard M. Cooper, David T. Wong, Douglas P. Wagner, William A. Knaus, Charul A. Munshi, John P. Kampine, I. D. Soutter, A. Mathieu, A. Gafni, A. Dauphin, L. Torsher, M. Tierney, H. S. Hopkins, G. J. Baylon, Elizabeth A. Peter, C. P. Bellhouse, Caroline Dore, T. W. Rachwal, D. T. Lanigan, Raymond Yip, J. B. Derdemezi, B. A. Britt, D. E. Withington, F. Reynolds, A. Patrick, W. Man, N. R. Searle, H. Ste-Marie, Mark A. Kostash, Richard Johnston, R. J. Bailey, M. D. Sharpe, R. P. Woda, M. Haug, P. Slugg, J. Lockrem, G. Barnett, B. A. Finegan, M. Robertson, D. Taylor, G. Frost, A. Koshal, Grant E. Rodney, Clayton C. Reichert, Desmond N. O’Regan, Derek Blackstock, David J. Steward, Richard Wenstone, Ellen Harrington, A. Wong, B. Braude, D. Fear, B. Bissonnette, Craig W. Reid, Kathryn A. Hull, S. Yogendran, G. McGuire, V. Chan, E. Hartley, K. Van Kessel, R. Weisel, N. Takla, N. A. Tremblay, F. E. Ralley, J. G. Ramsay, G. R. Robbins, F. C. Salevsky, S. Gandhi, N. Nimphius, Bernard Dionne, Christian Jodoin, Michel Lorange, Alain Lapointe, Geoffrey Hawboldt, G. A. Volgyesi, Guy Tousignant, R. Barnett, and B. Gallant

Subjects
Anesthesiology and Pain Medicine, General Medicine
Published
1992
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2. NSAIDs and balanced analgesia

Author

W. Code

Subjects
Drug, medicine.medical_specialty, media_common.quotation_subject, Premedication, Pain, Anesthesiology, medicine, Phenylbutazone, Humans, Tolmetin, Child, media_common, Aspirin, Analgesics, Pain, Postoperative, business.industry, Anti-Inflammatory Agents, Non-Steroidal, Infant, General Medicine, Perioperative, medicine.disease, Salicylates, Acetaminophen, Anesthesiology and Pain Medicine, Anesthesia, Renal blood flow, Heart failure, Female, Analgesia, Propionates, business, Ketorolac, medicine.drug
Abstract

Anaesthetists have changed their drug regimens several times in the last few decades. Today, anaesthesia is most frequently carried out with a "balanced" combination of agents to achieve optimal surgical anaesthesia and enhance recovery. Similarly, analgesia, one of the comerstones of anaesthesia, is increasingly considered with a combination of pharmacological agents and the term "balanced analgesia" is frequently considered. Opioids are no longer the sole entity for analgesia as anaesthetists now can combine local anaesthetics and/or non-steroidal anti-inflammatory drugs (NSAIDs) to optimize pain management in the perioperative period. Wall has suggested that prophylactic use of analgesics may decrease their postoperative requirements by reducing noxious input and thereby minimizing the hyperexcitable "windup" state in the central nervous system. 1 NSAID's inhibition of prostaglandin synthesis may reduce peripheral nociception and hence reduce the pain and inflammatory response to surgical trauma. In the following discussion, I will outline the strengths, weaknesses, and potential indications of NSAIDs as applied to the perioperative period. The NSAIDs include a wide number of pharmacological groups under one umbrella. Goodman and Gillman et al. (G and G) outline the prototype aspirin (acetylsalicylic acid), the near historical phenylbutazone and incorporate acetaminophen (paracetamol) into this group. 2 They list the common side effects including gastric or intestinal ulceration, altered platelet function (for the platelet's life with aspirin but a reversible cyclooxygenase inhibition related to the NSAID's half-life), prolongation of gestation (prostaglandins of the E and F series are potent uterotropic agents) and relatively rarely renal dysfunction. 2 The NSAIDs may decrease renal blood flow and the rate of glomerular fdtration in patients who have congestive heart failure, hepatic cirrhosis with ascites, hypovolaemia or chronic renal disease. 2 Clinical action of NSAIDs can vary from drug group to drug group, drug to drug and, as shown in rheuma

Published
1993

3. Closed loop stability of measure-driven impulsive control systems.

Author

W. Code and G. Silva

Subjects
*LOOPS (Group theory), *STABILITY (Mechanics), *CONTROL theory (Engineering), *DYNAMICS, *FEEDBACK control systems, *MATHEMATICAL analysis
Abstract

Abstract  Closed loop stabilization of impulsive control systems containing a measure in the dynamics is considered. It is proved that, as for regular affine systems, an almost everywhere continuous stabilizing impulsive feedback control law exists for such impulsive systems. An example illustrating the loop closing features is also presented. [ABSTRACT FROM AUTHOR]

Published
2010
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4. Erratum

Author

Saiah Michèle, Borgeat Alain, Wilder-Smith Oliver, Orlando R. Hung, Charles E. Hope, Geoffrey Laney, Sara C. Whynot, Thomas J. Coonan, David S. Malloy, S. Patterson, A. Gelb, P. Manninen, D. Strum, B. Glosten, M. J. Spellman, E. I. Eger, R. A. Craen, A. W. Gelb, J. M. Murkin, K. Y. Chong, D. H. Penning, H. El-Behairy, J. F. Brien, J. W. Coh, R. Arellano, J. Correa, L. Fedorko, Z. Liu, J. F. Boylan, A. N. Sandler, H. Nierenberg, P. A. Sheiner, P. D. Greig, G. M. O’Leary, S. J. Teasdale, M. F. X. Glynn, B. A. Orser, L. -Y. Wang, J. F. MacDonald, C. W. Loomis, K. D. Arunachalam, D. Vyas, B. Milne, Daniel Gagnon, Josée Lavoie, Jean-Yves Dupuis, D. R. Miller, R. J. Martineau, D. Greenway, L. Olivaris, K. Hull, R. N. M. Tierney, J. E. Wynands, R. Martineau, B. St-Jean, J. Kitts, D. Miller, P. Lindsay, M. Curran, G. C. Allen, M. L. Crossan, Richard Wise, François Donati, David R. Bevan, J. F. Hardy, J. Desroches, J. Perrault, M. Carrier, D. Robitaille, D. M. Ansley, J. P. O’Connor, J. Dolman, G. E. Townsend, D. Ricci, D. J. Liepert, P. M. Browne, T. Hertz, M. Rooney, R. W. Yip, W. Code, A. A. Phillips, R. F. McLean, J. H. Devitt, E. M. Harrington, R. J. Byrick, P. Y. Wong, D. Wigglesworth, J. C. Kay, L. A. Sinclair, J. P. Koch, K. A. Deemar, G. K. Christakis, S. Belo, P. Angle, D. Cheng, J. Boylan, A. Sandler, C. Feindel, F. Carmichael, P. Boylen, L. G. R. DeLima, H. J. Nathan, M. S. Hynes, M. E. Bourke, G. N. Russell, C. Seyone, F. Chung, Daniel Chartrand, Lucie Roux, S. L. Dain, B. D. Smith, A. C. Webster, D. F. Wigglesworth, D. K. Rose, G. Caskennette, C. Mechetuk, D. John Doyle, Wilfred DeMajo, Frank Bosch, Mark Lee, K. M. McClenaghan, C. D. Mazer, R. Preston, E. T. Crosby, D. Kotarba, H. Dudas, R. D. Elliott, J. Enns, P. H. Manninen, J. K. Farrar, David L. Huzyka, L. Philip Lin, Susan Fossey, Brendan T. Finucane, M. Stockwell, S. Lozanoff, S. Lang, J. Hyssen, D. C. Campbell, M. J. Douglas, T. J. G. Pavy, M. L. Flanagan, G. H. McMorland, Colin Bands, Ch. B. Ffaracs, Catherine Lipsett, David Drover, Mark Stafford-Smith, Sarah Stevens, Kate Shields, Michael J. MacSween, J. D. McAllister, P. K. Morley-Forster, A. K. White, M. D. Taylor, H. M. Vandenberghe, D. Knoppert, H. Reimer, P. C. Duke, C. H. Kehler, M. W. Kepron, V. A. Taraska, J. Carstoniu, P. Norman, J. Katz, Medhat Hannallah, C. M. Cooney, J. B. Lyons, A. Hennigan, W. P. Blunnie, D. C. Moriarty, W. B. Dobkowski, F. S. Prato, N. A. Shannon, D. J. Drost, B. Arya, J. M. Wills, D. Bond, P. Morley-Forester, Mullen JB, I. Spahr-Schopfer, J. Lerman, E. Cutz, M. Dolovich, S. Kowalski, B. Ong, D. Bell, T. Ostryzniuk, C. Serrette, T. Wasylak, S. Coke, Takako Tsuda, Takashi Nakagawa, Norifumi Mabuchi, Hiroshi Ando, Osamu Nishida, Takafumi Azami, Hirotada Katsuya, Yukio Goto, N. Searle, M. Roy, null R. R. T., Charles E. Smith, Alfred C. Pinchak, Joan F. Hagen, Donald Hancock, Andrei V. Krassioukov, Lynne C. Weaver, I. R. Sutton, W. A. C. Mutch, J. M. Teskey, I. R. Thomson, M. Rosenbloom, D. Thiessen, S. Teasdale, H. Corbin, M. R. Graham, S. A. Lang, P. Chang, M. Gerard, J. E. Tetzlaff, M. Walsh, H. Yoon, Brian Warriner, Peter Fancourt-Smith, Jim McEwen, Judy Crane, N. H. Badner, R. Bhandari, W. E. Komar, S. Ganapathy, C. B. Warriner, J. P. McCormack, M. Levine, N. Glick, V. W. S. Chan, M. McQuestion, M. Gomez, C. Cruise, D. Evana, D. Shumka, R. J. Smyth, M. Graham, David Halpenny, Gerald V. Goresky, J. Eldon Zaretski, B. Kavanagh, S. Roger, A. Davies, M. Friedlander, M. M. Cohen, P. G. Duncan, W. D. B. Pope, D. Biehl, R. Merchant, W. A. Tweed, Michael J. Tessler, Mark Angle, Simcha Kleiman, B. P. Kavanagh, G. J. Doak, G. Li, R. I. Hall, J. A. Sulliyan, I. Yee, S. Halpern, R. Pittini, C. Huh, G. L. Bryson, R. Gverzdys, C. Perreault, L. Ferland, F. Gobeil, D. Girard, R. Smyth, B. Asokumar, M. Glynn, Sandra Silveira, Jeff Clark, Paul Milgram, W. M. Splinter, H. B. MacNeill, E. A. Ménard, E. J. Rhine, D. J. Roberts, G. M. Gould, G. G. Johnson, Daniel Quance, Saul Wiesel, Jane Easdown, N. Tien Truong, Normand Miller, Nathan Sheiner, L. Welborn, J. Norden, R. Hannallah, L. Broadman, N. Seiden, M. Iwai, R. Iwai, H. Horigome, M. Yamashita, Catherine E. Wood, Kim Klassen, S. Kleinman, S. Yentis, N. Sikich, T. A. Yemen, B. Mascik, W. Nelson, H. Ghantous, J. Gandolfi, Gordon Wood, Mohamed Ali, Kevin Inman, J. M. Karski, J. Carroll, D. Brooks, P. A. Oakley, P. M. Webster, J. Karski, T. Yao, J. Ivanov, P. Young, S. Carson, R. D. Weisel, Richard M. Cooper, David T. Wong, Douglas P. Wagner, William A. Knaus, Charul A. Munshi, John P. Kampine, I. D. Soutter, A. Mathieu, A. Gafni, A. Dauphin, L. Torsher, M. Tierney, H. S. Hopkins, G. J. Baylon, Elizabeth A. Peter, C. P. Bellhouse, Caroline Dore, T. W. Rachwal, D. T. Lanigan, Raymond Yip, J. B. Derdemezi, B. A. Britt, D. E. Withington, F. Reynolds, A. Patrick, W. Man, N. R. Searle, H. Ste-Marie, Mark A. Kostash, Richard Johnston, R. J. Bailey, M. D. Sharpe, R. P. Woda, M. Haug, P. Slugg, J. Lockrem, G. Barnett, B. A. Finegan, M. Robertson, D. Taylor, G. Frost, A. Koshal, Grant E. Rodney, Clayton C. Reichert, Desmond N. O’Regan, Derek Blackstock, David J. Steward, Richard Wenstone, Ellen Harrington, A. Wong, B. Braude, D. Fear, B. Bissonnette, Craig W. Reid, Kathryn A. Hull, S. Yogendran, G. McGuire, V. Chan, E. Hartley, K. Kessel, R. Weisel, N. Takla, N. A. Tremblay, F. E. Ralley, J. G. Ramsay, G. R. Robbins, F. C. Salevsky, S. Gandhi, N. Nimphius, Bernard Dionne, Christian Jodoin, Michel Lorange, Alain Lapointe, Geoffrey Hawboldt, G. A. Volgyesi, Guy Tousignant, R. Barnett, and B. Gallant

Subjects
Anesthesiology and Pain Medicine, General Medicine
Published
1992
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7. Evolving gene targets and technology in influenza detection.

Author

Malanoski AP and Lin B

Subjects
Disease Outbreaks, Epidemiological Monitoring, Humans, Influenza Vaccines, Influenza, Human epidemiology, Orthomyxoviridae genetics, Reagent Kits, Diagnostic, Genes, Viral, Influenza, Human diagnosis, Influenza, Human virology, Orthomyxoviridae classification, Orthomyxoviridae isolation & purification
Abstract

Influenza viruses cause recurring epidemic outbreaks every year associated with high morbidity and mortality. Despite extensive research and surveillance efforts to control influenza outbreaks, the primary mitigation treatment for influenza is the development of yearly vaccine mixes targeted for the most prevalent virus strains. Consequently, the focus of many detection technologies has evolved toward accurate identification of subtype and understanding the evolution and molecular determinants of novel and pathogenic forms of influenza. The recent availability of potential antiviral treatments are only effective if rapid and accurate diagnostic tests for influenza epidemic management are available; thus, early detection of influenza infection is still important for prevention, containment, patient management, and infection control. This review discusses the current and emerging technologies for detection and strain identification of influenza virus and their specific gene targets, as well as their implications in patient management.

Published
2013
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8. NSAIDs and balanced analgesia.

Author

Code W

Subjects
Analgesics adverse effects, Analgesics pharmacology, Child, Female, Humans, Infant, Ketorolac, Pain drug therapy, Pain prevention & control, Pain, Postoperative drug therapy, Pain, Postoperative prevention & control, Premedication, Propionates adverse effects, Propionates pharmacology, Salicylates adverse effects, Salicylates pharmacology, Tolmetin adverse effects, Tolmetin analogs & derivatives, Tolmetin pharmacology, Analgesia, Anti-Inflammatory Agents, Non-Steroidal adverse effects, Anti-Inflammatory Agents, Non-Steroidal pharmacology
Published
1993
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9. During repetitive forebrain ischemia, post-ischemic hypothermia protects neurons from damage.

Author

Shuaib A, Ijaz S, Kalra J, and Code W

Subjects
Animals, Brain pathology, Electroencephalography, Gerbillinae, Ischemic Attack, Transient pathology, Ischemic Attack, Transient physiopathology, Male, Neurons pathology, Recurrence, Hypothermia, Induced, Ischemic Attack, Transient therapy, Prosencephalon blood supply
Abstract

In rodents damage from repetitive transient cerebral ischemia is more severe than that seen with a single ischemic insult of similar duration. Mild hypothermia has been shown to be very effective in protecting the brain during single ischemic insults. We tested the protective effects of hypothermia in repetitive ischemic insults. We used the gerbil model of repetitive ischemia (three minutes ischemia repeated at one hourly intervals three times) and histological evaluation was done using the silver staining technique. Our study reveals that a decrease in body and scalp temperature by 1-2 degrees Celsius can significantly reduce neuronal damage in the cerebral cortex, CA1 region of the hippocampus and substantia nigra reticulata during repetitive ischemia. As the hypothermia was induced after the initial insult, we believe this offers an opportunity for intervention in the clinical settings.

Published
1992

10. Hypothermia protects astrocytes during ischemia in cell culture.

Author

Shuaib A, Sochocka E, Code W, and Hertz L

Subjects
Animals, Astrocytes enzymology, Cells, Cultured, L-Lactate Dehydrogenase metabolism, Mice, Astrocytes physiology, Cold Temperature, Ischemia physiopathology
Abstract

A mild decrease in temperature (2-3 degrees) can result in marked attenuation of ischemic neuronal damage in living animals. We now report the protective effects of hypothermia in an astrocyte with simulated ischemia in cell culture system. Hypothermia when used during ischemia showed significant reduction of damage. Brief episodes of post-ischemic hypothermia were not protective whereas more prolonged post-ischemic hypothermia showed moderate protection. Cell culture systems may prove to be useful tools to study the mechanisms of hypothermic protection during ischemia.

Published
1992
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11. Repetitive transient forebrain ischemia in gerbils: delayed neuronal damage in the substantia nigra reticulata.

Author

Shuaib A, Ijaz S, Kalra J, and Code W

Subjects
Animals, Gerbillinae, Male, Substantia Nigra cytology, Time Factors, Ischemic Attack, Transient pathology, Nerve Degeneration physiology, Neurons pathology, Prosencephalon blood supply, Substantia Nigra pathology
Abstract

Repetitive cerebral ischemia results in severe neuronal damage in multiple regions of the brain including the hippocampus, striatum, thalamus, medial geniculate nucleus and the substantia nigra reticulata (SNr). We postulated that the damage in the SNr was delayed, resulting from a loss of striatal inhibitory input. We used the gerbil model of repetitive ischemia (3 min times 2 and 3 min times 3) to evaluate the extent of neuronal damage at 2, 3, 5 and 7 days after the ischemic insult. Silver degeneration stain was used for histological evaluation. Our results indicate that damage in the SNr begins after 48 h and is maximum at 7 days. This delay in onset of damage offers a window for pharmacological protection.

Published
1992
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