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3,514 results on '"W. Arnold"'

1. Transient Middle Cerebral Artery Occlusion with an Intraluminal Suture Enables Reproducible Induction of Ischemic Stroke in Mice

Author

Luke Lemmerman, Hallie Harris, Maria Balch, Maria Rincon-Benavides, Natalia Higuita-Castro, W. Arnold, and Daniel Gallego-Perez

Subjects
Biology (General), QH301-705.5
Abstract

Ischemic stroke is a leading cause of mortality and chronic disability worldwide, underscoring the need for reliable and accurate animal models to study this disease’s pathology, molecular mechanisms of injury, and treatment approaches. As most clinical strokes occur in regions supplied by the middle cerebral artery (MCA), several experimental models have been developed to simulate an MCA occlusion (MCAO), including transcranial MCAO, micro- or macro-sphere embolism, thromboembolisation, photothrombosis, Endothelin-1 injection, and – the most common method for ischemic stroke induction in murine models – intraluminal MCAO. In the intraluminal MCAO model, the external carotid artery (ECA) is permanently ligated, after which a partially-coated monofilament is inserted and advanced proximally to the common carotid artery (CCA) bifurcation, before being introduced into the internal carotid artery (ICA). The coated tip of the monofilament is then advanced to the origin of the MCA and secured for the duration of occlusion. With respect to other MCAO models, this model offers enhanced reproducibility regarding infarct volume and cognitive/functional deficits, and does not require a craniotomy. Here, we provide a detailed protocol for the surgical induction of unilateral transient ischemic stroke in mice, using the intraluminal MCAO model.Graphic abstract: Overview of the intraluminal monofilament method for transient middle cerebral artery occlusion (MCAO) in mouse.

Published
2022
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2. Review: Seasonal differences in the physiology of wild northern ruminants

Author

W. Arnold

Subjects
seasonal acclimatization, metabolic rate, thermoregulation, digestion, organ size, Animal culture, SF1-1100
Abstract

Ruminants living in seasonal environments face a two-fold challenge during winter. The energetic cost of maintaining a high body temperature is higher at lower ambient temperatures, and this is compounded by poor availability and quality of feed. Wild ruminants acclimatize to this energetic challenge by hypothermia, that is, reduced endogenous heat production and abandoning the maintenance of a high body temperature, particularly in peripheral body parts. Further but lesser contributions to lower energy expenditure during winter are reduced foraging activity; lower heat increment of feeding; and reduced maintenance cost of size-reduced organs. Altogether, metabolic rate, estimated by the continuous measurement of heart rate, during winter is downregulated to more than half of the summer level, as is voluntary food intake, even in animals fed ad libitum. The transformation from the summer into the thrifty winter phenotype is also evident in the physiology of digestion. Microbial protein synthesis is less facilitated by diminished phosphorus secretion into the shrunk rumen during winter. In line with this result, the concentration of ammonia, the end-product of protein digestion in the rumen, peaks in rumen liquid in spring, whereas the molar proportion of acetate, an indicator of fermentation of a diet rich in fiber, peaks in winter. In contrast to reduced stimulation of growth of ruminal microbes during winter, active transport of nutrients across the intestinal epithelium is increased, resulting in more efficient exploitation of the lower amount and quality of ingested winter feed. Nevertheless, the energy balance remains negative during winter. This is compensated by using fat reserves accumulated during summer, which become a major metabolic fuel during winter.

Published
2020
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3. The neuromuscular impact of symptomatic SMN restoration in a mouse model of spinal muscular atrophy

Author

W. Arnold, Vicki L. McGovern, Benjamin Sanchez, Jia Li, Kaitlyn M. Corlett, Stephen J. Kolb, Seward B. Rutkove, and Arthur H. Burghes

Subjects
Spinal muscular atrophy, Biomarker, Survival motor neuron, Antisense oligonucleotide, Electrical impedance myography, Motor unit number estimation, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571
Abstract

Background: Significant advances in the development of SMN-restoring therapeutics have occurred since 2010 when very effective biological treatments were reported in mouse models of spinal muscular atrophy. As these treatments are applied in human clinical trials, there is pressing need to define quantitative assessments of disease progression, treatment stratification, and therapeutic efficacy. The electrophysiological measures Compound Muscle Action Potential and Motor Unit Number Estimation are reliable measures of nerve function. In both the SMN∆7 mouse and a pig model of spinal muscular atrophy, early SMN restoration results in preservation of electrophysiological measures. Currently, clinical trials are underway in patients at post-symptomatic stages of disease progression. In this study, we present results from both early and delayed SMN restoration using clinically-relevant measures including electrical impedance myography, compound muscle action potential, and motor unit number estimation to quantify the efficacy and time-sensitivity of SMN-restoring therapy. Methods: SMA∆7 mice were treated via intracerebroventricular injection with antisense oligonucleotides targeting ISS-N1 to increase SMN protein from the SMN2 gene on postnatal day 2, 4, or 6 and compared with sham-treated spinal muscular atrophy and control mice. Compound muscle action potential and motor unit number estimation of the triceps surae muscles were performed at day 12, 21, and 30 by a single evaluator blinded to genotype and treatment. Similarly, electrical impedance myography was measured on the biceps femoris muscle at 12 days for comparison. Results: Electrophysiological measures and electrical impedance myography detected significant differences at 12 days between control and late-treated (4 or 6 days) and sham-treated spinal muscular atrophy mice, but not in mice treated at 2 days (p

Published
2016
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6. Muerte encefálica: consideraciones clínicas y legales

Author

W. Arnold Hoppe, Dr.

Subjects
Muerte encefálica /di (diagnóstico), muerte encefálica /pp (fisiopatología), muerte encefálica /lj (legislación & jurisprudencia), trasplante de órganos /lj (legislación & jurisprudencia), examen neurológico/ st (normas) examen neurológico/ mt (métodos), apnea /di (diagnóstico), actitud frente a la muerte, actitud del personal de salud, características culturales, Chile, Medicine
Abstract

Temor y ambivalencia son aspectos centrales en la matriz sociocultural relacionada con la muerte encefálica. Para el médico que debe evaluar pacientes y certificar el diagnóstico de muerte encefálica es crucial contar con una sólida comprensión de la fisiopatología, los criterios diagnósticos y de los exámenes complementarios. La existencia de un marco legal coherente y completo para el diagnóstico de muerte encefálica, independiente de la potencial donación de órganos, es ciertamente crucial para el médico. La relevancia que tiene en este sentido el fallo del Tribunal Constitucional de Chile del 13 de agosto de 1995 se analiza en profundidad.

Published
2010
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21. C lostridioides difficile toxin is infrequently detected in inflammatory bowel disease and does not associate with clinical outcomes

Author

Rachel Bernard, Muhammad B. Hammami, Forest W. Arnold, Brian Mcgrath, Alieysa Patel, Brandon Wuerth, Maribeth R. Nicholson, Krishna Rao, and Dejan Micic

Subjects
Inflammatory bowel disease, Clostridium difficile, Colitis, Diseases of the digestive system. Gastroenterology, RC799-869
Abstract

Abstract Introduction Clostridioides difficile infection (CDI) rates and outcomes can vary based on differences in testing strategy. Our aim was to assess the prevalence of toxin detection in inflammatory bowel disease (IBD) when compared to those without IBD. Secondly, the clinical outcomes of CDI in IBD were assessed using two-step testing strategies. Methods We included patients undergoing CDI testing from four academic centers in the United States between January 1, 2018 and June 30, 2020. First the prevalence of toxin detection was compared between individuals with IBD and those without IBD. Secondly, among patients with IBD a primary composite outcome of abdominal colectomy, admission to an intensive care unit (ICU) or death within 30 days of C. difficile testing was assessed across the three categorical groups (screen positive/toxin positive, screen positive/toxin negative and screen negative assay) resulting from the two-step testing strategy. Results When comparing individuals with a positive screening assay, patients with IBD were less likely to have toxin detected by enzyme immunoassay (EIA) as compared to the non-IBD population (22/145 (15.2%) vs. 413/1144 (36.1%), p

Published
2022
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28. Multi-site, Multi-domain Airway Tree Modeling (ATM'22): A Public Benchmark for Pulmonary Airway Segmentation.

Author

Minghui Zhang, Yangqian Wu, Hanxiao Zhang, Yulei Qin, Hao Zheng 0008, Wen Tang, Corey W. Arnold, Chenhao Pei, Pengxin Yu, Yang Nan 0002, Guang Yang 0006, Simon Walsh, Dominic C. Marshall, Matthieu Komorowski, Puyang Wang, Dazhou Guo, Dakai Jin, Yanan Wu, Shuiqing Zhao, Runsheng Chang, Boyu Zhang, Xing Lv, Abdul Qayyum, Moona Mazher, Qi Su, Yonghuang Wu, Ying'ao Liu, Yufei Zhu, Jiancheng Yang, Ashkan Pakzad, Bojidar Rangelov, Raúl San José Estépar, Carlos Cano-Espinosa, Jiayuan Sun, Guang-Zhong Yang, and Yun Gu

Published
2023
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46. Multi-site, Multi-domain Airway Tree Modeling.

Author

Minghui Zhang, Yangqian Wu, Hanxiao Zhang, Yulei Qin, Hao Zheng 0008, Wen Tang, Corey W. Arnold, Chenhao Pei, Pengxin Yu, Yang Nan 0002, Guang Yang 0006, Simon Walsh, Dominic C. Marshall, Matthieu Komorowski, Puyang Wang, Dazhou Guo, Dakai Jin, Yanan Wu, Shuiqing Zhao, Runsheng Chang, Boyu Zhang, Xing Lu, Abdul Qayyum, Moona Mazher, Qi Su, Yonghuang Wu, Ying'ao Liu, Yufei Zhu, Jiancheng Yang, Ashkan Pakzad, Bojidar Rangelov, Raúl San José Estépar, Carlos Cano-Espinosa, Jiayuan Sun, Guang-Zhong Yang, and Yun Gu

Published
2023
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47. Band Wear and Effects on Recovery and Survival Estimates of Diving Ducks

Author

Michael L. Szymanski, Todd W. Arnold, Pamela R. Garrettson, and Alan D. Afton

Subjects
Aythya affinis, Aythya americana, band wear, double‐band, functional band loss, incoloy, General. Including nature conservation, geographical distribution, QH1-199.5
Abstract

ABSTRACT Wildlife biologists commonly use marked individuals to estimate population size and vital rates. If markers are lost or become too illegible to be reported (which we define as functional loss), population size and vital rates derived from marked individuals could be biased. We double‐banded 4,990 lesser scaup (Aythya affinis) and 1,429 redheads (A. americana) with a traditionally used band made of aluminum, plus another band made of incoloy designed to be more resistant to wear. Banding took place at 10 late‐summer banding stations in the northcentral United States and Canada during 2009 and 2010 and during spring at Pool 19 on the Mississippi River, Iowa, USA, during 2009–2011. We then examined bands recovered from hunter‐shot birds to assess wear of paired bands. We also conducted band‐recovery analyses to test for differences in band retention and reporting rates between birds banded with aluminum versus hard metal bands. Band wear assessments indicated that incoloy bands lost zero mass over time and showed no effects of wear. Although no bands were lost, aluminum bands showed significant mass loss and wear over time. For double‐banded lesser scaup recovered in their fourth year after banding, 71.9% of aluminum bands had contact information that was completely unreadable, compared with only 12.5% for those worn by redheads. Based on our recent double‐band recovery data, up to 34% of lesser scaup bands would be recovered during the fifth through eighth hunting seasons of band wear. Band wear affected estimated recovery rates of both species, with stronger effects in lesser scaup. Our results indicate that use of aluminum bands resulted in a substantial loss of information; thus, banders should only use bands made of hard metal alloys (e.g., incoloy or stainless steel), and discontinue all use of aluminum bands for these species and other diving ducks with sparse recovery data. Future demographic analyses using banding data for species with excessive band wear and low numbers of band‐recoveries should account for band type and functional band loss. © 2020 The Wildlife Society.

Published
2020
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50. Relative particle yield fluctuations in $$\text{ Pb--Pb }$$ Pb--Pb collisions at $$\sqrt{s_\mathrm{{NN}}} =2.76\hbox { TeV}$$ sNN=2.76TeV

Author

S. Acharya, D. Adamová, J. Adolfsson, M. M. Aggarwal, G. Aglieri Rinella, M. Agnello, N. Agrawal, Z. Ahammed, S. U. Ahn, S. Aiola, A. Akindinov, M. Al-Turany, S. N. Alam, D. S. D. Albuquerque, D. Aleksandrov, B. Alessandro, R. Alfaro Molina, Y. Ali, A. Alici, A. Alkin, J. Alme, T. Alt, L. Altenkamper, I. Altsybeev, C. Alves Garcia Prado, C. Andrei, D. Andreou, H. A. Andrews, A. Andronic, V. Anguelov, C. Anson, T. Antičić, F. Antinori, P. Antonioli, L. Aphecetche, H. Appelshäuser, S. Arcelli, R. Arnaldi, O. W. Arnold, I. C. Arsene, M. Arslandok, B. Audurier, A. Augustinus, R. Averbeck, M. D. Azmi, A. Badalà, Y. W. Baek, S. Bagnasco, R. Bailhache, R. Bala, A. Baldisseri, M. Ball, R. C. Baral, A. M. Barbano, R. Barbera, F. Barile, L. Barioglio, G. G. Barnaföldi, L. S. Barnby, V. Barret, P. Bartalini, K. Barth, E. Bartsch, N. Bastid, S. Basu, G. Batigne, B. Batyunya, P. C. Batzing, J. L. BazoAlba, I. G. Bearden, H. Beck, C. Bedda, N. K. Behera, I. Belikov, F. Bellini, H. Bello Martinez, R. Bellwied, L. G. E. Beltran, V. Belyaev, G. Bencedi, S. Beole, A. Bercuci, Y. Berdnikov, D. Berenyi, R. A. Bertens, D. Berzano, L. Betev, A. Bhasin, I. R. Bhat, B. Bhattacharjee, J. Bhom, A. Bianchi, L. Bianchi, N. Bianchi, C. Bianchin, J. Bielčík, J. Bielčíková, A. Bilandzic, G. Biro, R. Biswas, S. Biswas, J. T. Blair, D. Blau, C. Blume, G. Boca, F. Bock, A. Bogdanov, L. Boldizsár, M. Bombara, G. Bonomi, M. Bonora, J. Book, H. Borel, A. Borissov, M. Borri, E. Botta, C. Bourjau, L. Bratrud, P. Braun-Munzinger, M. Bregant, T. A. Broker, M. Broz, E. J. Brucken, E. Bruna, G. E. Bruno, D. Budnikov, H. Buesching, S. Bufalino, P. Buhler, P. Buncic, O. Busch, Z. Buthelezi, J. B. Butt, J. T. Buxton, J. Cabala, D. Caffarri, H. Caines, A. Caliva, E. Calvo Villar, P. Camerini, A. A. Capon, F. Carena, W. Carena, F. Carnesecchi, J. Castillo Castellanos, A. J. Castro, E. A. R. Casula, C. Ceballos Sanchez, S. Chandra, B. Chang, W. Chang, S. Chapeland, M. Chartier, S. Chattopadhyay, A. Chauvin, C. Cheshkov, B. Cheynis, V. Chibante Barroso, D. D. Chinellato, S. Cho, P. Chochula, M. Chojnacki, S. Choudhury, T. Chowdhury, P. Christakoglou, C. H. Christensen, P. Christiansen, T. Chujo, S. U. Chung, C. Cicalo, L. Cifarelli, F. Cindolo, J. Cleymans, F. Colamaria, D. Colella, A. Collu, M. Colocci, M. Concas, G. Conesa Balbastre, Z. Conesa del Valle, J. G. Contreras, T. M. Cormier, Y. Corrales Morales, I. Cortés Maldonado, P. Cortese, M. R. Cosentino, F. Costa, S. Costanza, J. Crkovská, P. Crochet, E. Cuautle, L. Cunqueiro, T. Dahms, A. Dainese, M. C. Danisch, A. Danu, D. Das, I. Das, S. Das, A. Dash, S. Dash, S. De, A. De Caro, G. de Cataldo, C. de Conti, J. de Cuveland, A. De Falco, D. De Gruttola, N. De Marco, S. De Pasquale, R. D. De Souza, H. F. Degenhardt, A. Deisting, A. Deloff, C. Deplano, P. Dhankher, D. Di Bari, A. Di Mauro, P. Di Nezza, B. Di Ruzza, M. A. Diaz Corchero, T. Dietel, P. Dillenseger, Y. Ding, R. Divià, Ø. Djuvsland, A. Dobrin, D. Domenicis Gimenez, B. Dönigus, O. Dordic, L. V. R. Doremalen, A. K. Dubey, A. Dubla, L. Ducroux, S. Dudi, A. K. Duggal, M. Dukhishyam, P. Dupieux, R. J. Ehlers, D. Elia, E. Endress, H. Engel, E. Epple, B. Erazmus, F. Erhardt, B. Espagnon, G. Eulisse, J. Eum, D. Evans, S. Evdokimov, L. Fabbietti, J. Faivre, A. Fantoni, M. Fasel, L. Feldkamp, A. Feliciello, G. Feofilov, A. Fernández Téllez, E. G. Ferreiro, A. Ferretti, A. Festanti, V. J. G. Feuillard, J. Figiel, M. A. S. Figueredo, S. Filchagin, D. Finogeev, F. M. Fionda, M. Floris, S. Foertsch, P. Foka, S. Fokin, E. Fragiacomo, A. Francescon, A. Francisco, U. Frankenfeld, G. G. Fronze, U. Fuchs, C. Furget, A. Furs, M. Fusco Girard, J. J. Gaardhøje, M. Gagliardi, A. M. Gago, K. Gajdosova, M. Gallio, C. D. Galvan, P. Ganoti, C. Garabatos, E. Garcia-Solis, K. Garg, C. Gargiulo, P. Gasik, E. F. Gauger, M. B. Gay Ducati, M. Germain, J. Ghosh, P. Ghosh, S. K. Ghosh, P. Gianotti, P. Giubellino, P. Giubilato, E. Gladysz-Dziadus, P. Glässel, D. M. Goméz Coral, A. Gomez Ramirez, A. S. Gonzalez, V. Gonzalez, P. González-Zamora, S. Gorbunov, L. Görlich, S. Gotovac, V. Grabski, L. K. Graczykowski, K. L. Graham, L. Greiner, A. Grelli, C. Grigoras, V. Grigoriev, A. Grigoryan, S. Grigoryan, J. M. Gronefeld, F. Grosa, J. F. Grosse-Oetringhaus, R. Grosso, F. Guber, R. Guernane, B. Guerzoni, K. Gulbrandsen, T. Gunji, A. Gupta, R. Gupta, I. B. Guzman, R. Haake, C. Hadjidakis, H. Hamagaki, G. Hamar, J. C. Hamon, M. R. Haque, J. W. Harris, A. Harton, H. Hassan, D. Hatzifotiadou, S. Hayashi, S. T. Heckel, E. Hellbär, H. Helstrup, A. Herghelegiu, E. G. Hernandez, G. Herrera Corral, F. Herrmann, B. A. Hess, K. F. Hetland, H. Hillemanns, C. Hills, B. Hippolyte, B. Hohlweger, D. Horak, S. Hornung, R. Hosokawa, P. Hristov, C. Hughes, T. J. Humanic, N. Hussain, T. Hussain, D. Hutter, D. S. Hwang, S. A. Iga Buitron, R. Ilkaev, M. Inaba, M. Ippolitov, M. S. Islam, M. Ivanov, V. Ivanov, V. Izucheev, B. Jacak, N. Jacazio, P. M. Jacobs, M. B. Jadhav, S. Jadlovska, J. Jadlovsky, S. Jaelani, C. Jahnke, M. J. Jakubowska, M. A. Janik, P. H. S. Y. Jayarathna, C. Jena, M. Jercic, R. T. Jimenez Bustamante, P. G. Jones, A. Jusko, P. Kalinak, A. Kalweit, J. H. Kang, V. Kaplin, S. Kar, A. KarasuUysal, O. Karavichev, T. Karavicheva, L. Karayan, P. Karczmarczyk, E. Karpechev, U. Kebschull, R. Keidel, D. L. D. Keijdener, M. Keil, B. Ketzer, Z. Khabanova, P. Khan, S. A. Khan, A. Khanzadeev, Y. Kharlov, A. Khatun, A. Khuntia, M. M. Kielbowicz, B. Kileng, B. Kim, D. Kim, D. J. Kim, H. Kim, J. S. Kim, J. Kim, M. Kim, S. Kim, T. Kim, S. Kirsch, I. Kisel, S. Kiselev, A. Kisiel, G. Kiss, J. L. Klay, C. Klein, J. Klein, C. Klein-Bösing, S. Klewin, A. Kluge, M. L. Knichel, A. G. Knospe, C. Kobdaj, M. Kofarago, M. K. Köhler, T. Kollegger, V. Kondratiev, N. Kondratyeva, E. Kondratyuk, A. Konevskikh, M. Konyushikhin, M. Kopcik, M. Kour, C. Kouzinopoulos, O. Kovalenko, V. Kovalenko, M. Kowalski, G. Koyithatta Meethaleveedu, I. Králik, A. Kravčáková, L. Kreis, M. Krivda, F. Krizek, E. Kryshen, M. Krzewicki, A. M. Kubera, V. Kučera, C. Kuhn, P. G. Kuijer, A. Kumar, J. Kumar, L. Kumar, S. Kumar, S. Kundu, P. Kurashvili, A. Kurepin, A. B. Kurepin, A. Kuryakin, S. Kushpil, M. J. Kweon, Y. Kwon, S. L. La Pointe, P. La Rocca, C. Lagana Fernandes, Y. S. Lai, I. Lakomov, R. Langoy, K. Lapidus, C. Lara, A. Lardeux, A. Lattuca, E. Laudi, R. Lavicka, R. Lea, L. Leardini, S. Lee, F. Lehas, S. Lehner, J. Lehrbach, R. C. Lemmon, E. Leogrande, I. León Monzón, P. Lévai, X. Li, J. Lien, R. Lietava, B. Lim, S. Lindal, V. Lindenstruth, S. W. Lindsay, C. Lippmann, M. A. Lisa, V. Litichevskyi, W. J. Llope, D. F. Lodato, P. I. Loenne, V. Loginov, C. Loizides, P. Loncar, X. Lopez, E. López Torres, A. Lowe, P. Luettig, J. R. Luhder, M. Lunardon, G. Luparello, M. Lupi, T. H. Lutz, A. Maevskaya, M. Mager, S. M. Mahmood, A. Maire, R. D. Majka, M. Malaev, L. Malinina, D. Mal’Kevich, P. Malzacher, A. Mamonov, V. Manko, F. Manso, V. Manzari, Y. Mao, M. Marchisone, J. Mareš, G. V. Margagliotti, A. Margotti, J. Margutti, A. Marín, C. Markert, M. Marquard, N. A. Martin, P. Martinengo, J. A. L. Martinez, M. I. Martínez, G. Martínez García, M. Martinez Pedreira, S. Masciocchi, M. Masera, A. Masoni, E. Masson, A. Mastroserio, A. M. Mathis, P. F. T. Matuoka, A. Matyja, C. Mayer, J. Mazer, M. Mazzilli, M. A. Mazzoni, F. Meddi, Y. Melikyan, A. Menchaca-Rocha, E. Meninno, J. Mercado Pérez, M. Meres, S. Mhlanga, Y. Miake, M. M. Mieskolainen, D. L. Mihaylov, K. Mikhaylov, A. Mischke, A. N. Mishra, D. Miśkowiec, J. Mitra, C. M. Mitu, N. Mohammadi, A. P. Mohanty, B. Mohanty, M. Mohisin Khan, E. Montes, D. A. Moreira De Godoy, L. A. P. Moreno, S. Moretto, A. Morreale, A. Morsch, V. Muccifora, E. Mudnic, D. Mühlheim, S. Muhuri, J. D. Mulligan, M. G. Munhoz, K. Münning, R. H. Munzer, H. Murakami, S. Murray, L. Musa, J. Musinsky, C. J. Myers, J. W. Myrcha, D. Nag, B. Naik, R. Nair, B. K. Nandi, R. Nania, E. Nappi, A. Narayan, M. U. Naru, H. Natal da Luz, C. Nattrass, S. R. Navarro, K. Nayak, R. Nayak, T. K. Nayak, S. Nazarenko, R. A. Negrao De Oliveira, L. Nellen, S. V. Nesbo, F. Ng, M. Nicassio, M. Niculescu, J. Niedziela, B. S. Nielsen, S. Nikolaev, S. Nikulin, V. Nikulin, F. Noferini, P. Nomokonov, G. Nooren, J. C. C. Noris, J. Norman, A. Nyanin, J. Nystrand, H. Oeschler, H. Oh, A. Ohlson, T. Okubo, L. Olah, J. Oleniacz, A. C. Oliveira Da Silva, M. H. Oliver, J. Onderwaater, C. Oppedisano, R. Orava, M. Oravec, A. Ortiz Velasquez, A. Oskarsson, J. Otwinowski, K. Oyama, Y. Pachmayer, V. Pacik, D. Pagano, G. Paić, P. Palni, J. Pan, A. K. Pandey, S. Panebianco, V. Papikyan, P. Pareek, J. Park, S. Parmar, A. Passfeld, S. P. Pathak, R. N. Patra, B. Paul, H. Pei, T. Peitzmann, X. Peng, L. G. Pereira, H. Pereira Da Costa, D. Peresunko, E. Perez Lezama, V. Peskov, Y. Pestov, V. Petráček, V. Petrov, M. Petrovici, C. Petta, R. P. Pezzi, S. Piano, M. Pikna, P. Pillot, L. O. D. L. Pimentel, O. Pinazza, L. Pinsky, D. B. Piyarathna, M. Płoskoń, M. Planinic, F. Pliquett, J. Pluta, S. Pochybova, P. L. M. Podesta-Lerma, M. G. Poghosyan, B. Polichtchouk, N. Poljak, W. Poonsawat, A. Pop, H. Poppenborg, S. Porteboeuf-Houssais, V. Pozdniakov, S. K. Prasad, R. Preghenella, F. Prino, C. A. Pruneau, I. Pshenichnov, M. Puccio, V. Punin, J. Putschke, S. Raha, S. Rajput, J. Rak, A. Rakotozafindrabe, L. Ramello, F. Rami, D. B. Rana, R. Raniwala, S. Raniwala, S. S. Räsänen, B. T. Rascanu, D. Rathee, V. Ratza, I. Ravasenga, K. F. Read, K. Redlich, A. Rehman, P. Reichelt, F. Reidt, X. Ren, R. Renfordt, A. Reshetin, K. Reygers, V. Riabov, T. Richert, M. Richter, P. Riedler, W. Riegler, F. Riggi, C. Ristea, M. Rodríguez Cahuantzi, K. Røed, E. Rogochaya, D. Rohr, D. Röhrich, P. S. Rokita, F. Ronchetti, E. D. Rosas, P. Rosnet, A. Rossi, A. Rotondi, F. Roukoutakis, C. Roy, P. Roy, A. J. Rubio Montero, O. V. Rueda, R. Rui, B. Rumyantsev, A. Rustamov, E. Ryabinkin, Y. Ryabov, A. Rybicki, S. Saarinen, S. Sadhu, S. 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Zhu, J. Zhu, Y. Zhu, A. Zichichi, M. B. Zimmermann, G. Zinovjev, J. Zmeskal, S. Zou, and ALICE Collaboration

Subjects
Astrophysics, QB460-466, Nuclear and particle physics. Atomic energy. Radioactivity, QC770-798
Abstract

Abstract First results on $$\hbox {K}/\pi $$ K/π , $$\hbox {p}/\pi $$ p/π and K/p fluctuations are obtained with the ALICE detector at the CERN LHC as a function of centrality in $$\text{ Pb--Pb }$$ Pb--Pb collisions at $$\sqrt{s_\mathrm{{NN}}} =2.76\hbox { TeV}$$ sNN=2.76TeV . The observable $$\nu _{\mathrm{dyn}}$$ νdyn , which is defined in terms of the moments of particle multiplicity distributions, is used to quantify the magnitude of dynamical fluctuations of relative particle yields and also provides insight into the correlation between particle pairs. This study is based on a novel experimental technique, called the Identity Method, which allows one to measure the moments of multiplicity distributions in case of incomplete particle identification. The results for $$\hbox {p}/\pi $$ p/π show a change of sign in $$\nu _{\mathrm{dyn}}$$ νdyn from positive to negative towards more peripheral collisions. For central collisions, the results follow the smooth trend of the data at lower energies and $$\nu _{\mathrm{dyn}}$$ νdyn exhibits a change in sign for $$\hbox {p}/\pi $$ p/π and K/p.

Published
2019
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