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The Ground Wide Angle Camera Network (GWAC-N) is a network of robotic multi-aperture, multiple field-of-view (FoV) optical telescopes. The main contingent of GWAC-N instruments are provided by the Ground Wide Angle Cameras Array (GWAC-A), and additional, narrower FoV telescopes are utilized to provide fast multi-band follow-up capabilities. The primary scientific goal of the GWAC-N is to search for optical counterparts of gamma-ray bursts that will be detected by the Space Variable Object Monitor (SVOM) satellite. The GWAC-N performs many additional observing tasks including follow-up of Target of Opportunities (ToO) targets and the detection (and monitoring) of variable objects and optical transients. To handle these use cases (and to allow for extensibility), we have designed ten observation modes and 175 observation strategies, including a joint strategy with multiple GWAC-N telescopes for the follow-up of gravitational wave (GW) events. To perform these observations, we develop an Automatic Observation Management (AOM) system capable of performing object management, dynamic scheduling, automatic broadcasting across the network, and image handling. The AOM system combines the individual telescopes which comprise the GWAC-N into a network and smoothly organizes all associated operations, completely meeting the requirements dictated by GWAC-N. With its modular design, the AOM is scientifically and technically viable for other general-purpose telescope networks. As the GWAC-N extends and evolves, the AOM will greatly enhance its discovery potential. In this first paper of a series, we present the scientific goals of the GWAC-N and detail the hardware, software, and workflow developed to achieve these goals. The structure, technical design, implementation, and performance of the AOM system are also described in detail. We conclude with a summary of the current status of the GWAC-N and our near-future development plan.

With the continuous development of informatization, big data has been increasingly used in the prevention and control of chronic diseases, which has a significant and considerable influence on public health. This paper briefly introduces the definition, characteristics and classification of big data and healthy big data, focusing on the analysis methods and their applications in tertiary prevention, as well as the challenges in technology, data management, sharing and quality, ethics and privacy, with the aim of providing more research approaches for healthy big data application in chronic disease prevention and control.随着信息化的不断发展，大数据（big data）正在越来越多地被运用于慢性病预防控制领域，对居民健康产生重大且深远的影响。本文简要地介绍了大数据和健康大数据（healthy big data）的定义、特征和分类；重点阐述了健康大数据的分析方法及其在慢性病三级预防中的应用；健康大数据应用所面临的技术难题、数据管理和共享、数据质量、伦理和隐私等诸多方面的挑战。为健康大数据在慢性病预防控制方面提供更多研究思路。.

Harmful drinking causes serious consequences to social security as well as physical and mental health of the general public. The Global Burden of Disease Study (2017) showed that the number of alcohol-related deaths in China in 2017 was 1.82 times higher than that in 1990, and the population attributable fraction increased by 44.13%. The burden of disease caused by drinking alcohol had been increasing. By comparing with the comprehensive intervention strategy of restricting harmful drinking put forward by the World Health Organization, we suggest that the current interventions that need to be improved in China should include several aspects below: (1) strengthening the control of alcohol production, marketing and circulation, (2) restricting the availability of alcohol products for minors through enterprise self-discipline, laws and regulations, parents and school health education, (3) bridging gaps in appropriate techniques and services for alcohol restriction/abstinence in the health care system, (4) providing services such as rapid screening of alcohol dependence and short abstinence interventions, (5) strengthening restrictions on alcohol advertising especially in new media (e.g., online and social media) marketing practices for alcohol products, (6) conducting scientific research and evaluation on alcohol tax-related issues, and (7) regularly reviewing alcohol prices related to inflation and income levels.有害饮酒给社会安全和身心健康带来严重危害。全球疾病负担研究（2017）显示2017年我国饮酒致死的人数是1990年的1.82倍，导致的死亡人群归因分值增幅达44.13%。饮酒导致的疾病负担日益严重。通过与世界卫生组织提出的限制有害饮酒综合干预策略比对分析发现，我们认为当前我国有待完善的干预领域包括加强酒类生产、销售和流通环节的管控，通过企业自律、法规宣贯、家长和学校健康教育限制未成年人的酒类产品的可获得性；在医疗卫生体系中填补限酒/戒酒适宜技术和服务的空白，提供酒精依赖快速筛查、简短戒酒干预等服务；加强酒类广告的限制措施，尽快出台新媒体（如网络、社交媒体）酒类产品营销活动规范；针对酒税问题开展科学研究和评估，定期审查与通货膨胀和收入水平相关的酒类价格。.

Corneal allograft rejection is an immunological hypersensitive reaction caused by the antigenicity of the donor cornea. This study aimed to explore the effects of RMT1-10 on the prevention of corneal graft rejection by modifying immunological characteristics of dendritic cells (DCs).DCs and CD4+T cells were sorted using flow cytometry and used for in vitro mixed lymphocyte culture. The cultured cells were prepared for the characterization of the DC cell phenotypes using the markers CD11c, CD80, MHC II, CD54, and TIM-4. Cytokine concentrations of IL-4, IL-12, and IL-10 of supernatants were measured by the enzyme-linked immunosorbent assay. CD4+T cells were examined by flow cytometry for apoptosis and proliferation. We also investigated the effect of RMT1-10 in the prevention and treatment of high-risk corneal graft rejection using a mouse model of corneal transplantation.DCs were identified as the CD11c+MHC-II-expressing subset. RMT1-10 suppressed the expression of CD11c, CD80, MHC II, CD54, and TIM-4 of DCs using the blockade of TIM-1 signaling. Moreover, TIM-1 blockade inhibited the production of IL-12 and IL-10 in a mixed lymphocyte culture system. However, a TIM-1 blockade had no effect on the apoptosis of CD4+T cells. RMT1-10 suppressed DC maturation, inhibiting the proliferation of CD4+T cells.RMT1-10 significantly improved the survival rate of the corneal allografts in mice compared with saline-injected controls. This clinical improvement from RMT1-10 occurred through the inhibition of CD4+T cell proliferation. Moreover, RMT1-10 induced antigen-specific detection of receptor immune tolerance. The cross-linking of TIM-1 on CD4+T cells with the agonist mAb provided a costimulatory inhibition signal for T cell activation or proliferation.

2018 witnessed the 40(th) anniversary of the Alma-Ata Declaration. On October 25, 2018, the World Health Organization issued a new Astana Declaration, which reiterates and further develops the concept and core elements of primary health care. It is also proposes that the implementation of the primary health care concept will facilitate to cope with the increasing burden of non-communicable diseases in different countries. Based on the analysis on the policies and practices of the prevention and control of non-communicable diseases in China, this paper points out that the "government-leading, multi-sectoral collaboration, social mobilization and participation by all people" which we have always emphasized is just the application of this primary health care concept, and the Astana Declaration also brings a new and important inspiration to the prevention and control of non-communicable diseases in China.2018年是《阿拉木图宣言》发布40周年，WHO于10月25日发布了新的《阿斯塔纳宣言》，其中重申并进一步发展了基本卫生保健理念和核心要素，还提出践行基本卫生保健理念将有助于应对各国目前不断增加的慢性病疾病负担。本文通过对我国慢性病防控政策与实践的分析，提出一直强调的"政府主导、部门协作、动员社会、全民参与"正是对基本卫生保健理念的应用，而《阿斯塔纳宣言》也将对中国慢性病防控带来新的重要启示。.

The second observational campaign of gravitational waves organized by the LIGO/Virgo Collaborations has led to several breakthroughs such as the detection of gravitational wave signals from merger systems involving black holes or neutrons stars. During O2,14 gravitational wave alerts were sent to the astronomical community with sky regions covering mostly over hundreds of square degrees. Among them, 6 have been finally confirmed as real astrophysical events. Since 2013, a new set of ground-based robotic telescopes called GWAC and its pathfinder mini-GWAC have been developed to contribute to the various challenges of themulti-messenger and time domain astronomy. The GWAC system is built up in the framework of the ground-segment system of the SVOM mission that will be devoted to the study of the multi-wavelength transient sky in the next decade. During O2, only the mini-GWAC telescopenetwork was fully operational. Due to the wide field of view and fast automatic follow-up capabilities of the mini-GWAC telescopes, they were well adapted to efficiently cover the sky localization areas of the gravitational wave event candidates. In this paper, we present the mini-GWAC pipeline we have set up to respond to the GW alerts and we report our optical follow-up observations of 8 GW alerts detected during the O2 run. Our observations provided the largest coverage of the GW localization areas in a short latency made by any optical facility. We found tens of optical transient candidates in our images, but none of those could be securely associated with any confirmed black hole-black hole merger event. Based on this first experience and the near future technical improvements of our network system, we will be more competitive to detect the optical counterparts from some gravitational wave events that will be detected during the upcoming O3 run, especially those emerging from binary neutron star mergers., 17 pages, 10 figures, 11 tables

Catastrophic disasters occur frequently in recent years, resulting in a large number of casualties. Thus, more and more scholars begin to focus on a newly emerged displine-rescue medicine. This paper introduces the status quo of rescue medicine and expounds the practical experience related to rescue medicine as practiced by author's unit, in order to provide a reference for the establishment of the discipline and its future development.