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610 results on '"Vuorinen, Tytti"'

3. Enterovirus D68 Outbreak in Children, Finland, August-September 2022

Author

Peltola, Ville, Osterback, Riikka, Waris, Matti, Ivaska, Lauri, Tahtinen, Paula A., Laine, Miia, and Vuorinen, Tytti

Subjects
Statistics, Causes of, Enterovirus infections -- Statistics -- Causes of, Pediatric research, Epidemics -- Statistics -- Causes of -- Finland, Pediatric communicable diseases -- Statistics -- Causes of, Enterovirus diseases -- Statistics -- Causes of, Communicable diseases in children -- Statistics -- Causes of
Abstract

Widespread enterovirus D68 (EV-D68) epidemics occurred in the United States and in other parts of the world in 2014, 2016, and 2018 (2,2). Low-level EV-D68 detection was reported in the [...]

Published
2023
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11. Incidence Trends for SARS-CoV-2 Alpha and Beta Variants, Finland, Spring 2021

Author

Kant, Ravi, Nguyen, Phuoc Truong, Blomqvist, Soile, Erdin, Mert, Alburkat, Hussein, Suvanto, Maija, Zakham, Fathiah, Salminen, Veera, Olander, Viktor, Paloniemi, Minna, Huhti, Leena, Lehtinen, Sara, Luukinen, Bruno, Jarva, Hanna, Kallio-Kokko, Hannimari, Kurkela, Satu, Lappalainen, Maija, Liimatainen, Hanna, Hannula, Sari, Halkilahti, Jani, Ikonen, Jonna, Ikonen, Niina, Helve, Otto, Gunell, Marianne, Vuorinen, Tytti, Plyusnin, Ilya, Lindh, Erika, Ellonen, Pekka, Sironen, Tarja, Savolainen-Kopra, Carita, Smura, Teemu, and Vapalahti, Olli

Subjects
Statistics, Identification and classification, Genetic aspects, Causes of, Forecasts and trends, Market trend/market analysis, SARS-CoV-2 variants -- Statistics -- Identification and classification -- Genetic aspects, Epidemics -- Statistics -- Causes of -- Forecasts and trends -- Finland, COVID-19 -- Statistics -- Causes of -- Forecasts and trends
Abstract

Several new variants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have emerged globally, most notably variants of concern Alpha (B.1.1.7) (1), Beta (B1.351) (2), Gamma (P.1) (3), and most [...]

Published
2021
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13. Regulated on Activation, Normal T cell Expressed and Secreted (RANTES) drives the resolution of allergic asthma

Author

Li, Nina, Mirzakhani, Hoomann, Kiefer, Alexander, Koelle, Julia, Vuorinen, Tytti, Rauh, Manfred, Yang, Zuqin, Krammer, Susanne, Xepapadaki, Paraskevi, Lewandowska-Polak, Anna, Lukkarinen, Heikki, Zhang, Nan, Stanic, Barbara, Zimmermann, Theodor, Kowalski, Marek L., Jartti, Tuomas, Bachert, Claus, Akdis, Mübeccel, Papadopoulos, Nikolaos G., Raby, Benjamin A., Weiss, Scott T., and Finotto, Susetta

Published
2021
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14. Household Transmission and Clinical Features of Respiratory Tract Infections That Were SARS-CoV-2 Positive and Negative.

Author

Ahti, Jaakko, Toivonen, Laura, Ollila, Helena, Ivaska, Lauri, Salo-Tuominen, Krista, Vuorinen, Tytti, Lempainen, Johanna, and Peltola, Ville

Subjects
SARS-CoV-2 Omicron variant, RESPIRATORY infections, SARS-CoV-2, POLYMERASE chain reaction, VIRAL transmission
Abstract

Background Comparative data are limited on the transmission of respiratory infections positive and negative for SARS-CoV-2 in households with children. Methods In June to August 2020, we recruited 700 participants (175 households, 376 children, 324 adults) to be prospectively followed for all respiratory tract infections. Follow-up lasted from recruitment until April 2022. Daily symptoms were monitored by weekly electronic questionnaires. SARS-CoV-2 polymerase chain reaction testing from nasopharyngeal specimens was performed for symptomatic participants and twice (1-week interval) for the household members of positive participants. Clinical features and secondary attack rates (SARs) based on the onset of symptoms were compared between respiratory infections that were SARS-CoV-2 positive and negative. Results Most SARS-CoV-2 infections (90%) occurred from January to April 2022 when Omicron BA.1 and BA.2 were the dominant variants. SARS-CoV-2–positive infections were transmitted more often than SARS-CoV-2–negative infections (SAR, 41% vs 24%; P <.001). SARS-CoV-2 transmission was similar for child and adult index cases (SAR, 40% vs 43%; P =.47), but the transmission of SARS-CoV-2–negative infections was higher for child index cases (SAR, 27% vs 18%; P <.001). Conclusions Our findings demonstrate that SARS-CoV-2 Omicron viruses spread more effectively within households as compared with other respiratory infections. [ABSTRACT FROM AUTHOR]

Published
2024
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18. Heterozygous TLR3 Mutation in Patients with Hantavirus Encephalitis

Author

Partanen, Terhi, Chen, Jie, Lehtonen, Johanna, Kuismin, Outi, Rusanen, Harri, Vapalahti, Olli, Vaheri, Antti, Anttila, Veli-Jukka, Bode, Michaela, Hautala, Nina, Vuorinen, Tytti, Glumoff, Virpi, Kraatari, Minna, Åström, Pirjo, Saarela, Janna, Kauma, Heikki, Lorenzo, Lazaro, Casanova, Jean-Laurent, Zhang, Shen-Ying, Seppänen, Mikko, and Hautala, Timo

Published
2020
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30. Human bocavirus 1 coinfection is associated with decreased cytokine expression in the rhinovirus‐induced first wheezing episode in children

Author

Hurme, Pekka; https://orcid.org/0000-0002-9748-2442, Sahla, Reetta, Rückert, Beate; https://orcid.org/0000-0003-1804-1698, Vahlberg, Tero, Turunen, Riitta, Vuorinen, Tytti, Akdis, Mubeccel; https://orcid.org/0000-0003-0554-9943, Söderlund‐Venermo, Maria, Akdis, Cezmi; https://orcid.org/0000-0001-8020-019X, Jartti, Tuomas, Hurme, Pekka; https://orcid.org/0000-0002-9748-2442, Sahla, Reetta, Rückert, Beate; https://orcid.org/0000-0003-1804-1698, Vahlberg, Tero, Turunen, Riitta, Vuorinen, Tytti, Akdis, Mubeccel; https://orcid.org/0000-0003-0554-9943, Söderlund‐Venermo, Maria, Akdis, Cezmi; https://orcid.org/0000-0001-8020-019X, and Jartti, Tuomas

Abstract

Background Rhinovirus (RV)‐induced first wheezing episodes in children are associated with a markedly increased risk of asthma. Previous studies have suggested that human bocavirus 1 (HBoV1) may modify RV‐induced immune responses in young children. We investigated cytokine profiles of sole RV‐ and dual RV‐HBoV1‐induced first wheezing episodes, and their association with severity and prognosis. Methods Fifty‐two children infected with only RV and nine children infected with dual RV‐HBoV1, aged 3–23 months, with severe first wheezing episodes were recruited. At acute illness and 2 weeks later, peripheral blood mononuclear cells were isolated, and stimulated with anti‐CD3/anti‐CD28 in vitro. Multiplex ELISA was used to quantitatively identify 56 different cytokines at both study points. Patients were prospectively followed for 4 years. Results The mean age of the children was 14.3 months, and 30% were sensitized. During the acute illness, the adjusted analyses revealed a decrease in the expression of IL‐1b, MIP‐1b, Regulated upon activation, normal T cell expressed and presumably secreted (CCL5), TNF‐a, TARC, and ENA‐78 in the RV‐HBoV1 group compared with the RV group. In the convalescence phase, the RV‐HBoV1 group was characterized by decreased expression of Fractalkine, MCP‐3, and IL‐8 compared to the RV group. Furthermore, the hospitalization time was associated with the virus group and cytokine response (interaction p < 0.05), signifying that increased levels of epidermal growth factor and MIP‐1b were related with a shorter duration of hospitalization in the RV‐HBoV1 coinfection group but not in the RV group. Conclusions Different cytokine response profiles were detected between the RV and the RV‐HBoV1 groups. Our results show the idea that RV‐induced immune responses may be suppressed by HBoV1.

Published
2023

50. Long-Lasting T Cell Responses in BNT162b2 COVID-19 mRNA Vaccinees and COVID-19 Convalescent Patients

Author

Hurme, Antti, Jalkanen, Pinja, Heroum, Jemna, Liedes, Oona, Vara, Saimi, Melin, Merit, Teräsjärvi, Johanna, He, Quishui, Pöysti, Sakari, Hänninen, Arno, Jarmo, Oksi, Vuorinen, Tytti, Kantele, Anu, Tähtinen, Paula, Ivaska, Laura, Kakkola, Laura, Lempainen, Johanna, Julkunen, Ilkka, Department of Medicine, HUS Inflammation Center, Clinicum, and Infektiosairauksien yksikkö

Subjects
3121 General medicine, internal medicine and other clinical medicine
Published
2022

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