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1. NUMB as a Therapeutic Target for Melanoma

Author

Hristova, Denitsa M., Fukumoto, Takeshi, Takemori, Chihiro, Gao, Le, Hua, Xia, Wang, Joshua X., Li, Ling, Beqiri, Marilda, Watters, Andrea, Vultur, Adina, Gimie, Yusra, Rebecca, Vito, Samarkina, Anastasia, Jimbo, Haruki, Nishigori, Chikako, Zhang, Jie, Cheng, Chaoran, Wei, Zhi, Somasundaram, Rajasekharan, Fukunaga-Kalabis, Mizuho, and Herlyn, Meenhard

Published
2022
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2. Overcoming Intrinsic Multidrug Resistance in Melanoma by Blocking the Mitochondrial Respiratory Chain of Slow-Cycling JARID1Bhigh Cells

Author

Roesch, Alexander, Vultur, Adina, Bogeski, Ivan, Wang, Huan, Zimmermann, Katharina M, Speicher, David, Körbel, Christina, Laschke, Matthias W, Gimotty, Phyllis A, Philipp, Stephan E, Krause, Elmar, Pätzold, Sylvie, Villanueva, Jessie, Krepler, Clemens, Fukunaga-Kalabis, Mizuho, Hoth, Markus, Bastian, Boris C, Vogt, Thomas, and Herlyn, Meenhard

Subjects
Clinical Research, Cancer, Development of treatments and therapeutic interventions, 5.1 Pharmaceuticals, Antineoplastic Agents, Cisplatin, Drug Resistance, Neoplasm, Electron Transport, Gene Knockdown Techniques, Humans, Indoles, Jumonji Domain-Containing Histone Demethylases, Melanoma, Nuclear Proteins, Oligomycins, Repressor Proteins, Sulfonamides, Vemurafenib, Neurosciences, Oncology and Carcinogenesis, Oncology & Carcinogenesis
Abstract

Despite success with BRAFV600E inhibitors, therapeutic responses in patients with metastatic melanoma are short-lived because of the acquisition of drug resistance. We identified a mechanism of intrinsic multidrug resistance based on the survival of a tumor cell subpopulation. Treatment with various drugs, including cisplatin and vemurafenib, uniformly leads to enrichment of slow-cycling, long-term tumor-maintaining melanoma cells expressing the H3K4-demethylase JARID1B/KDM5B/PLU-1. Proteome-profiling revealed an upregulation in enzymes of mitochondrial oxidative-ATP-synthesis (oxidative phosphorylation) in this subpopulation. Inhibition of mitochondrial respiration blocked the emergence of the JARID1B(high) subpopulation and sensitized melanoma cells to therapy, independent of their genotype. Our findings support a two-tiered approach combining anticancer agents that eliminate rapidly proliferating melanoma cells with inhibitors of the drug-resistant slow-cycling subpopulation.

Published
2013

3. Supplementary Figure S6 from Hypoxia Induces Phenotypic Plasticity and Therapy Resistance in Melanoma via the Tyrosine Kinase Receptors ROR1 and ROR2

Author

O'Connell, Michael P., primary, Marchbank, Katie, primary, Webster, Marie R., primary, Valiga, Alexander A., primary, Kaur, Amanpreet, primary, Vultur, Adina, primary, Li, Ling, primary, Herlyn, Meenhard, primary, Villanueva, Jessie, primary, Liu, Qin, primary, Yin, Xiangfan, primary, Widura, Sandy, primary, Nelson, Janelle, primary, Ruiz, Nivia, primary, Camilli, Tura C., primary, Indig, Fred E., primary, Flaherty, Keith T., primary, Wargo, Jennifer A., primary, Frederick, Dennie T., primary, Cooper, Zachary A., primary, Nair, Suresh, primary, Amaravadi, Ravi K., primary, Schuchter, Lynn M., primary, Karakousis, Giorgos C., primary, Xu, Wei, primary, Xu, Xiaowei, primary, and Weeraratna, Ashani T., primary

Published
2023
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4. Data from Hypoxia Induces Phenotypic Plasticity and Therapy Resistance in Melanoma via the Tyrosine Kinase Receptors ROR1 and ROR2

Author

O'Connell, Michael P., primary, Marchbank, Katie, primary, Webster, Marie R., primary, Valiga, Alexander A., primary, Kaur, Amanpreet, primary, Vultur, Adina, primary, Li, Ling, primary, Herlyn, Meenhard, primary, Villanueva, Jessie, primary, Liu, Qin, primary, Yin, Xiangfan, primary, Widura, Sandy, primary, Nelson, Janelle, primary, Ruiz, Nivia, primary, Camilli, Tura C., primary, Indig, Fred E., primary, Flaherty, Keith T., primary, Wargo, Jennifer A., primary, Frederick, Dennie T., primary, Cooper, Zachary A., primary, Nair, Suresh, primary, Amaravadi, Ravi K., primary, Schuchter, Lynn M., primary, Karakousis, Giorgos C., primary, Xu, Wei, primary, Xu, Xiaowei, primary, and Weeraratna, Ashani T., primary

Published
2023
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6. Supplementary Data Figure Legends from Hypoxia Induces Phenotypic Plasticity and Therapy Resistance in Melanoma via the Tyrosine Kinase Receptors ROR1 and ROR2

Author

O'Connell, Michael P., primary, Marchbank, Katie, primary, Webster, Marie R., primary, Valiga, Alexander A., primary, Kaur, Amanpreet, primary, Vultur, Adina, primary, Li, Ling, primary, Herlyn, Meenhard, primary, Villanueva, Jessie, primary, Liu, Qin, primary, Yin, Xiangfan, primary, Widura, Sandy, primary, Nelson, Janelle, primary, Ruiz, Nivia, primary, Camilli, Tura C., primary, Indig, Fred E., primary, Flaherty, Keith T., primary, Wargo, Jennifer A., primary, Frederick, Dennie T., primary, Cooper, Zachary A., primary, Nair, Suresh, primary, Amaravadi, Ravi K., primary, Schuchter, Lynn M., primary, Karakousis, Giorgos C., primary, Xu, Wei, primary, Xu, Xiaowei, primary, and Weeraratna, Ashani T., primary

Published
2023
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7. Supplementary Table 2 from Hypoxia Induces Phenotypic Plasticity and Therapy Resistance in Melanoma via the Tyrosine Kinase Receptors ROR1 and ROR2

Author

O'Connell, Michael P., primary, Marchbank, Katie, primary, Webster, Marie R., primary, Valiga, Alexander A., primary, Kaur, Amanpreet, primary, Vultur, Adina, primary, Li, Ling, primary, Herlyn, Meenhard, primary, Villanueva, Jessie, primary, Liu, Qin, primary, Yin, Xiangfan, primary, Widura, Sandy, primary, Nelson, Janelle, primary, Ruiz, Nivia, primary, Camilli, Tura C., primary, Indig, Fred E., primary, Flaherty, Keith T., primary, Wargo, Jennifer A., primary, Frederick, Dennie T., primary, Cooper, Zachary A., primary, Nair, Suresh, primary, Amaravadi, Ravi K., primary, Schuchter, Lynn M., primary, Karakousis, Giorgos C., primary, Xu, Wei, primary, Xu, Xiaowei, primary, and Weeraratna, Ashani T., primary

Published
2023
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8. Data from Neural Crest-Like Stem Cell Transcriptome Analysis Identifies LPAR1 in Melanoma Progression and Therapy Resistance

Author

Liu, Jianglan, primary, Rebecca, Vito W., primary, Kossenkov, Andrew V., primary, Connelly, Thomas, primary, Liu, Qin, primary, Gutierrez, Alexis, primary, Xiao, Min, primary, Li, Ling, primary, Zhang, Gao, primary, Samarkina, Anastasia, primary, Zayasbazan, Delaine, primary, Zhang, Jie, primary, Cheng, Chaoran, primary, Wei, Zhi, primary, Alicea, Gretchen M., primary, Fukunaga-Kalabis, Mizuho, primary, Krepler, Clemens, primary, Aza-Blanc, Pedro, primary, Yang, Chih-Cheng, primary, Delvadia, Bela, primary, Tong, Cynthia, primary, Huang, Ye, primary, Delvadia, Maya, primary, Morias, Alice S., primary, Sproesser, Katrin, primary, Brafford, Patricia, primary, Wang, Joshua X., primary, Beqiri, Marilda, primary, Somasundaram, Rajasekharan, primary, Vultur, Adina, primary, Hristova, Denitsa M., primary, Wu, Lawrence W., primary, Lu, Yiling, primary, Mills, Gordon B., primary, Xu, Wei, primary, Karakousis, Giorgos C., primary, Xu, Xiaowei, primary, Schuchter, Lynn M., primary, Mitchell, Tara C., primary, Amaravadi, Ravi K., primary, Kwong, Lawrence N., primary, Frederick, Dennie T., primary, Boland, Genevieve M., primary, Salvino, Joseph M., primary, Speicher, David W., primary, Flaherty, Keith T., primary, Ronai, Ze'ev A., primary, and Herlyn, Meenhard, primary

Published
2023
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9. Table S5 from Neural Crest-Like Stem Cell Transcriptome Analysis Identifies LPAR1 in Melanoma Progression and Therapy Resistance

Author

Liu, Jianglan, primary, Rebecca, Vito W., primary, Kossenkov, Andrew V., primary, Connelly, Thomas, primary, Liu, Qin, primary, Gutierrez, Alexis, primary, Xiao, Min, primary, Li, Ling, primary, Zhang, Gao, primary, Samarkina, Anastasia, primary, Zayasbazan, Delaine, primary, Zhang, Jie, primary, Cheng, Chaoran, primary, Wei, Zhi, primary, Alicea, Gretchen M., primary, Fukunaga-Kalabis, Mizuho, primary, Krepler, Clemens, primary, Aza-Blanc, Pedro, primary, Yang, Chih-Cheng, primary, Delvadia, Bela, primary, Tong, Cynthia, primary, Huang, Ye, primary, Delvadia, Maya, primary, Morias, Alice S., primary, Sproesser, Katrin, primary, Brafford, Patricia, primary, Wang, Joshua X., primary, Beqiri, Marilda, primary, Somasundaram, Rajasekharan, primary, Vultur, Adina, primary, Hristova, Denitsa M., primary, Wu, Lawrence W., primary, Lu, Yiling, primary, Mills, Gordon B., primary, Xu, Wei, primary, Karakousis, Giorgos C., primary, Xu, Xiaowei, primary, Schuchter, Lynn M., primary, Mitchell, Tara C., primary, Amaravadi, Ravi K., primary, Kwong, Lawrence N., primary, Frederick, Dennie T., primary, Boland, Genevieve M., primary, Salvino, Joseph M., primary, Speicher, David W., primary, Flaherty, Keith T., primary, Ronai, Ze'ev A., primary, and Herlyn, Meenhard, primary

Published
2023
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10. Supplementary Figures from Neural Crest-Like Stem Cell Transcriptome Analysis Identifies LPAR1 in Melanoma Progression and Therapy Resistance

Author

Liu, Jianglan, primary, Rebecca, Vito W., primary, Kossenkov, Andrew V., primary, Connelly, Thomas, primary, Liu, Qin, primary, Gutierrez, Alexis, primary, Xiao, Min, primary, Li, Ling, primary, Zhang, Gao, primary, Samarkina, Anastasia, primary, Zayasbazan, Delaine, primary, Zhang, Jie, primary, Cheng, Chaoran, primary, Wei, Zhi, primary, Alicea, Gretchen M., primary, Fukunaga-Kalabis, Mizuho, primary, Krepler, Clemens, primary, Aza-Blanc, Pedro, primary, Yang, Chih-Cheng, primary, Delvadia, Bela, primary, Tong, Cynthia, primary, Huang, Ye, primary, Delvadia, Maya, primary, Morias, Alice S., primary, Sproesser, Katrin, primary, Brafford, Patricia, primary, Wang, Joshua X., primary, Beqiri, Marilda, primary, Somasundaram, Rajasekharan, primary, Vultur, Adina, primary, Hristova, Denitsa M., primary, Wu, Lawrence W., primary, Lu, Yiling, primary, Mills, Gordon B., primary, Xu, Wei, primary, Karakousis, Giorgos C., primary, Xu, Xiaowei, primary, Schuchter, Lynn M., primary, Mitchell, Tara C., primary, Amaravadi, Ravi K., primary, Kwong, Lawrence N., primary, Frederick, Dennie T., primary, Boland, Genevieve M., primary, Salvino, Joseph M., primary, Speicher, David W., primary, Flaherty, Keith T., primary, Ronai, Ze'ev A., primary, and Herlyn, Meenhard, primary

Published
2023
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13. Supplementary Figure S5 from The Novel SMAC Mimetic Birinapant Exhibits Potent Activity against Human Melanoma Cells

Author

Krepler, Clemens, primary, Chunduru, Srinivas K., primary, Halloran, Molly B., primary, He, Xu, primary, Xiao, Min, primary, Vultur, Adina, primary, Villanueva, Jessie, primary, Mitsuuchi, Yasuhiro, primary, Neiman, Eric M., primary, Benetatos, Christopher, primary, Nathanson, Katherine L., primary, Amaravadi, Ravi K., primary, Pehamberger, Hubert, primary, McKinlay, Mark, primary, and Herlyn, Meenhard, primary

Published
2023
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14. Data from Protein Signatures of NK Cell–Mediated Melanoma Killing Predict Response to Immunotherapies

Author

Cappello, Sabrina, primary, Sung, Hsu-Min, primary, Ickes, Christian, primary, Gibhardt, Christine S., primary, Vultur, Adina, primary, Bhat, Hilal, primary, Hu, Zhongwen, primary, Brafford, Patricia, primary, Denger, Andreas, primary, Stejerean-Todoran, Ioana, primary, Köhn, Rixa-Mareike, primary, Lorenz, Verena, primary, Künzel, Nicolas, primary, Salinas, Gabriela, primary, Stanisz, Hedwig, primary, Legler, Tobias, primary, Rehling, Peter, primary, Schön, Michael P., primary, Lang, Karl S., primary, Helms, Volkhard, primary, Herlyn, Meenhard, primary, Hoth, Markus, primary, Kummerow, Carsten, primary, and Bogeski, Ivan, primary

Published
2023
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15. Supplementary Table 2 from Brain Metastasis Cell Lines Panel: A Public Resource of Organotropic Cell Lines

Author

Valiente, Manuel, primary, Van Swearingen, Amanda E.D., primary, Anders, Carey K., primary, Bairoch, Amos, primary, Boire, Adrienne, primary, Bos, Paula D., primary, Cittelly, Diana M., primary, Erez, Neta, primary, Ferraro, Gino B., primary, Fukumura, Dai, primary, Gril, Brunilde, primary, Herlyn, Meenhard, primary, Holmen, Sheri L., primary, Jain, Rakesh K., primary, Joyce, Johanna A., primary, Lorger, Mihaela, primary, Massague, Joan, primary, Neman, Josh, primary, Sibson, Nicola R., primary, Steeg, Patricia S., primary, Thorsen, Frits, primary, Young, Leonie S., primary, Varešlija, Damir, primary, Vultur, Adina, primary, Weis-Garcia, Frances, primary, and Winkler, Frank, primary

Published
2023
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16. Supplementary Figures from Protein Signatures of NK Cell–Mediated Melanoma Killing Predict Response to Immunotherapies

Author

Cappello, Sabrina, primary, Sung, Hsu-Min, primary, Ickes, Christian, primary, Gibhardt, Christine S., primary, Vultur, Adina, primary, Bhat, Hilal, primary, Hu, Zhongwen, primary, Brafford, Patricia, primary, Denger, Andreas, primary, Stejerean-Todoran, Ioana, primary, Köhn, Rixa-Mareike, primary, Lorenz, Verena, primary, Künzel, Nicolas, primary, Salinas, Gabriela, primary, Stanisz, Hedwig, primary, Legler, Tobias, primary, Rehling, Peter, primary, Schön, Michael P., primary, Lang, Karl S., primary, Helms, Volkhard, primary, Herlyn, Meenhard, primary, Hoth, Markus, primary, Kummerow, Carsten, primary, and Bogeski, Ivan, primary

Published
2023
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17. Supplementary Table S1 from The Novel SMAC Mimetic Birinapant Exhibits Potent Activity against Human Melanoma Cells

Author

Krepler, Clemens, primary, Chunduru, Srinivas K., primary, Halloran, Molly B., primary, He, Xu, primary, Xiao, Min, primary, Vultur, Adina, primary, Villanueva, Jessie, primary, Mitsuuchi, Yasuhiro, primary, Neiman, Eric M., primary, Benetatos, Christopher, primary, Nathanson, Katherine L., primary, Amaravadi, Ravi K., primary, Pehamberger, Hubert, primary, McKinlay, Mark, primary, and Herlyn, Meenhard, primary

Published
2023
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18. Figure S1 from Brain Metastasis Cell Lines Panel: A Public Resource of Organotropic Cell Lines

Author

Valiente, Manuel, primary, Van Swearingen, Amanda E.D., primary, Anders, Carey K., primary, Bairoch, Amos, primary, Boire, Adrienne, primary, Bos, Paula D., primary, Cittelly, Diana M., primary, Erez, Neta, primary, Ferraro, Gino B., primary, Fukumura, Dai, primary, Gril, Brunilde, primary, Herlyn, Meenhard, primary, Holmen, Sheri L., primary, Jain, Rakesh K., primary, Joyce, Johanna A., primary, Lorger, Mihaela, primary, Massague, Joan, primary, Neman, Josh, primary, Sibson, Nicola R., primary, Steeg, Patricia S., primary, Thorsen, Frits, primary, Young, Leonie S., primary, Varešlija, Damir, primary, Vultur, Adina, primary, Weis-Garcia, Frances, primary, and Winkler, Frank, primary

Published
2023
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19. Supplementary Files 1-11 from Protein Signatures of NK Cell–Mediated Melanoma Killing Predict Response to Immunotherapies

Author

Cappello, Sabrina, primary, Sung, Hsu-Min, primary, Ickes, Christian, primary, Gibhardt, Christine S., primary, Vultur, Adina, primary, Bhat, Hilal, primary, Hu, Zhongwen, primary, Brafford, Patricia, primary, Denger, Andreas, primary, Stejerean-Todoran, Ioana, primary, Köhn, Rixa-Mareike, primary, Lorenz, Verena, primary, Künzel, Nicolas, primary, Salinas, Gabriela, primary, Stanisz, Hedwig, primary, Legler, Tobias, primary, Rehling, Peter, primary, Schön, Michael P., primary, Lang, Karl S., primary, Helms, Volkhard, primary, Herlyn, Meenhard, primary, Hoth, Markus, primary, Kummerow, Carsten, primary, and Bogeski, Ivan, primary

Published
2023
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20. Data from Brain Metastasis Cell Lines Panel: A Public Resource of Organotropic Cell Lines

Author

Valiente, Manuel, primary, Van Swearingen, Amanda E.D., primary, Anders, Carey K., primary, Bairoch, Amos, primary, Boire, Adrienne, primary, Bos, Paula D., primary, Cittelly, Diana M., primary, Erez, Neta, primary, Ferraro, Gino B., primary, Fukumura, Dai, primary, Gril, Brunilde, primary, Herlyn, Meenhard, primary, Holmen, Sheri L., primary, Jain, Rakesh K., primary, Joyce, Johanna A., primary, Lorger, Mihaela, primary, Massague, Joan, primary, Neman, Josh, primary, Sibson, Nicola R., primary, Steeg, Patricia S., primary, Thorsen, Frits, primary, Young, Leonie S., primary, Varešlija, Damir, primary, Vultur, Adina, primary, Weis-Garcia, Frances, primary, and Winkler, Frank, primary

Published
2023
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21. Supplementary Table 1 from Brain Metastasis Cell Lines Panel: A Public Resource of Organotropic Cell Lines

Author

Valiente, Manuel, primary, Van Swearingen, Amanda E.D., primary, Anders, Carey K., primary, Bairoch, Amos, primary, Boire, Adrienne, primary, Bos, Paula D., primary, Cittelly, Diana M., primary, Erez, Neta, primary, Ferraro, Gino B., primary, Fukumura, Dai, primary, Gril, Brunilde, primary, Herlyn, Meenhard, primary, Holmen, Sheri L., primary, Jain, Rakesh K., primary, Joyce, Johanna A., primary, Lorger, Mihaela, primary, Massague, Joan, primary, Neman, Josh, primary, Sibson, Nicola R., primary, Steeg, Patricia S., primary, Thorsen, Frits, primary, Young, Leonie S., primary, Varešlija, Damir, primary, Vultur, Adina, primary, Weis-Garcia, Frances, primary, and Winkler, Frank, primary

Published
2023
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22. 335 Analyses of severe immune-mediated toxicity in patients with advanced mCRPC treated with a PSMA-targeted armored CAR T-cells

Author

Gladney, Whitney, primary, Vultur, Adina, additional, Schweizer, Michael, additional, Fraietta, Joseph, additional, Rech, Andrew, additional, June, Carl, additional, O’Rourke, Matthew, additional, Roberts, Amy, additional, Patel, Hinel, additional, Rosen, Jamie, additional, Hufner, Pam, additional, Luo, Yanping, additional, Barrett, David, additional, Fountaine, Thomas, additional, and Chagin, Karen, additional

Published
2022
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23. MCU controls melanoma progression through a redox‐controlled phenotype switch

Author

Stejerean‐Todoran, Ioana, primary, Zimmermann, Katharina, additional, Gibhardt, Christine S, additional, Vultur, Adina, additional, Ickes, Christian, additional, Shannan, Batool, additional, Bonilla del Rio, Zuriñe, additional, Wölling, Anna, additional, Cappello, Sabrina, additional, Sung, Hsu‐Min, additional, Shumanska, Magdalena, additional, Zhang, Xin, additional, Nanadikar, Maithily, additional, Latif, Muhammad U, additional, Wittek, Anna, additional, Lange, Felix, additional, Waters, Andrea, additional, Brafford, Patricia, additional, Wilting, Jörg, additional, Urlaub, Henning, additional, Katschinski, Dörthe M, additional, Rehling, Peter, additional, Lenz, Christof, additional, Jakobs, Stefan, additional, Ellenrieder, Volker, additional, Roesch, Alexander, additional, Schön, Michael P, additional, Herlyn, Meenhard, additional, Stanisz, Hedwig, additional, and Bogeski, Ivan, additional

Published
2022
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24. A distinct pattern of growth and RAC1 signaling in melanoma brain metastasis cells

Author

Stejerean-Todoran, Ioana, primary, Gimotty, Phyllis A, additional, Watters, Andrea, additional, Brafford, Patricia, additional, Krepler, Clemens, additional, Godok, Tetiana, additional, Li, Haiyin, additional, Bonilla del Rio, Zuriñe, additional, Zieseniss, Anke, additional, Katschinski, Dörthe M, additional, Sertel, Sinem M, additional, Rizzoli, Silvio O, additional, Garman, Bradley, additional, Nathanson, Katherine L, additional, Xu, Xiaowei, additional, Chen, Qing, additional, Oswald, Jack H, additional, Lotem, Michal, additional, Mills, Gordon B, additional, Davies, Michael A, additional, Schön, Michael P, additional, Bogeski, Ivan, additional, Herlyn, Meenhard, additional, and Vultur, Adina, additional

Published
2022
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26. Acquired Resistance to BRAF Inhibitors Mediated by a RAF Kinase Switch in Melanoma Can Be Overcome by Cotargeting MEK and IGF-1R/PI3K

Author

Villanueva, Jessie, Vultur, Adina, Lee, John T., Somasundaram, Rajasekharan, Fukunaga-Kalabis, Mizuho, Cipolla, Angela K., Wubbenhorst, Bradley, Xu, Xiaowei, Gimotty, Phyllis A., Kee, Damien, Santiago-Walker, Ademi E., Letrero, Richard, D'Andrea, Kurt, Pushparajan, Anitha, Hayden, James E., Brown, Kimberly Dahlman, Laquerre, Sylvie, McArthur, Grant A., Sosman, Jeffrey A., Nathanson, Katherine L., and Herlyn, Meenhard

Published
2010
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27. Protein Signatures of NK Cell–Mediated Melanoma Killing Predict Response to Immunotherapies

Author

Cappello, Sabrina, primary, Sung, Hsu-Min, additional, Ickes, Christian, additional, Gibhardt, Christine S., additional, Vultur, Adina, additional, Bhat, Hilal, additional, Hu, Zhongwen, additional, Brafford, Patricia, additional, Denger, Andreas, additional, Stejerean-Todoran, Ioana, additional, Köhn, Rixa-Mareike, additional, Lorenz, Verena, additional, Künzel, Nicolas, additional, Salinas, Gabriela, additional, Stanisz, Hedwig, additional, Legler, Tobias, additional, Rehling, Peter, additional, Schön, Michael P., additional, Lang, Karl S., additional, Helms, Volkhard, additional, Herlyn, Meenhard, additional, Hoth, Markus, additional, Kummerow, Carsten, additional, and Bogeski, Ivan, additional

Published
2021
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28. Neural Crest-Like Stem Cell Transcriptome Analysis Identifies LPAR1 in Melanoma Progression and Therapy Resistance

Author

Liu, Jianglan, primary, Rebecca, Vito W., additional, Kossenkov, Andrew V., additional, Connelly, Thomas, additional, Liu, Qin, additional, Gutierrez, Alexis, additional, Xiao, Min, additional, Li, Ling, additional, Zhang, Gao, additional, Samarkina, Anastasia, additional, Zayasbazan, Delaine, additional, Zhang, Jie, additional, Cheng, Chaoran, additional, Wei, Zhi, additional, Alicea, Gretchen M., additional, Fukunaga-Kalabis, Mizuho, additional, Krepler, Clemens, additional, Aza-Blanc, Pedro, additional, Yang, Chih-Cheng, additional, Delvadia, Bela, additional, Tong, Cynthia, additional, Huang, Ye, additional, Delvadia, Maya, additional, Morias, Alice S., additional, Sproesser, Katrin, additional, Brafford, Patricia, additional, Wang, Joshua X., additional, Beqiri, Marilda, additional, Somasundaram, Rajasekharan, additional, Vultur, Adina, additional, Hristova, Denitsa M., additional, Wu, Lawrence W., additional, Lu, Yiling, additional, Mills, Gordon B., additional, Xu, Wei, additional, Karakousis, Giorgos C., additional, Xu, Xiaowei, additional, Schuchter, Lynn M., additional, Mitchell, Tara C., additional, Amaravadi, Ravi K., additional, Kwong, Lawrence N., additional, Frederick, Dennie T., additional, Boland, Genevieve M., additional, Salvino, Joseph M., additional, Speicher, David W., additional, Flaherty, Keith T., additional, Ronai, Ze'ev A., additional, and Herlyn, Meenhard, additional

Published
2021
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29. Melanoma

Author

Vultur, Adina, primary, Smalley, Keiran, additional, and Herlyn, Meenhard, additional

Published
2013
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31. Beyond structure, to survival: activation of stat3 by cadherin engagement

Author

Raptis, Leda, Arulanandam, Rozanne, Vultur, Adina, Geletu, Mulu, Chevalier, Sebastien, and Feracci, Helene

Subjects
Gene expression -- Research -- Health aspects, Cadherins -- Health aspects -- Research, Cancer -- Care and treatment, Biological sciences, Research, Health aspects
Abstract

Cells in normal tissues or in tumors have extensive opportunities for adhesion to their neighbors and the importance of cell to cell contact in the study of fundamental cellular processes is beginning to emerge. In this review, we discuss recent evidence of dramatic changes in the activity of an important signal transducer found to be profoundly affected by cell to cell adhesion, the signal transducer and activator of transcription-3 (Stat3). Direct cadherin engagement, growth of cells to postconfluence, or formation of multicellular aggregates were found to induce a striking increase in the levels of Stat3 activity, Rac1/Cdc42, and members of the IL6 receptor family in different settings. This activation was specific to Stat3, in that the levels of the extracellular signal regulated kinase (Erk1/2), a signal transducer often coordinately activated with Stat3 by a number of growth factors or oncogenes, remained unaffected by cell density. Density-dependent Stat3 activation may play a key role in survival, and could contribute to the establishment of cell polarity. It is clear that at any given time the total Stat3 activity levels in a cell are the sum of the effects of cell to cell adhesion plus the conventional Stat3 activating factors present. Key words: Stat3, E-cadherin, Rac1/Cdc42, signal transduction, cell survival. Les cellules des tissus normaux ou tumoraux ont de multiples opportunites d'adherer a leurs voisines et l'importance des contacts intercellulaires dans l'etude des processus cellulaires fondamentaux commence a emerger. Dans cet article de synthese, nous discutons des preuves des changements dramatiques qui surviennent dans l'activite d'un important transducteur de signaux profondement affecte par l'adhesion cellulaire, Stat3 (<< signal transducer and activator of transcription-3 >>). L'engagement direct des cadherines, la croissance des cellules en post-confluences ou la formation d'agregats multicellulaires induisent une augmentation remarquable des niveaux d'activite de Stat3, de Rac1/Cdc42 et des membres de la famille du recepteur de l'IL-6, dans differentes conditions. Cette activation est specifique a Stat3, car les niveaux de la kinase Erk1/2 (<< extracellular signal regulated kinase >>), un transducteur de signaux souvent active de facon coordonnee avec Stat3 par plusieurs facteurs de croissance ou oncogenes, ne sont pas affectes par la densite cellulaire. Cette activation de Stat3 dependante de la densite pourrait jouer un role cle dans la survie et pourrait contribuer a l'etablissement de la polarite cellulaire. De toute facon, il est clair qu'a tout moment les niveaux totaux d'activite de Stat3 dans une cellule sont la resultante des effets de l'adhesion cellule-cellule et de ceux des facteurs conventionnels d'activation de Stat3 presents. Mots-cles : Stat3, E-cadherine, Rac1/Cdc42, signaux de transduction, survie cellulaire., Introduction Cells in both normal tissues and tumors have extensive opportunities for adhesion to their neighbors in a three-dimensional organization, and it has recently become apparent that in the study [...]

Published
2009
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32. Differential effects of c-Ras upon transformation, adipocytic differentiation, and apoptosis mediated by the simian virus 40 large tumor antigen

Author

Cao, Jun, Arulanandam, Rozanne, Vultur, Adina, Anagnostopoulu, Aikaterini, and Raptis, Leda

Subjects
SV40 (Virus) -- Research, Cell differentiation -- Research, Apoptosis -- Research, Ras genes -- Research, Fat cells -- Research, Biological sciences, Research
Abstract

Abstract: To investigate the functional relationship between the ability of the simian virus 40 large tumor antigen (TAg) to transform and its ability to block adipocytic differentiation and induce apoptosis, [...]

Published
2007

34. Brain Metastasis Cell Lines Panel: A Public Resource of Organotropic Cell Lines

Author

Valiente, Manuel, primary, Van Swearingen, Amanda E.D., additional, Anders, Carey K., additional, Bairoch, Amos, additional, Boire, Adrienne, additional, Bos, Paula D., additional, Cittelly, Diana M., additional, Erez, Neta, additional, Ferraro, Gino B., additional, Fukumura, Dai, additional, Gril, Brunilde, additional, Herlyn, Meenhard, additional, Holmen, Sheri L., additional, Jain, Rakesh K., additional, Joyce, Johanna A., additional, Lorger, Mihaela, additional, Massague, Joan, additional, Neman, Josh, additional, Sibson, Nicola R., additional, Steeg, Patricia S., additional, Thorsen, Frits, additional, Young, Leonie S., additional, Varešlija, Damir, additional, Vultur, Adina, additional, Weis-Garcia, Frances, additional, and Winkler, Frank, additional

Published
2020
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37. 52. BrMPANEL: A PUBLIC RESOURCE OF ORGANOTROPIC CELL LINES

Author

Valiente, Manuel, primary, Van Swearingen, Amanda, additional, Anders, Carey, additional, Bairoch, Amos, additional, Boire, Adrienne, additional, Bos, Paula, additional, Cittelly, Diana, additional, Erez, Neta, additional, Ferrarro, Gino, additional, Fukumura, Dai, additional, Gril, Brunilde, additional, Herlyn, Meenhard, additional, Holmen, Sheri, additional, Jain, Rakesh, additional, Joyce, Johanna, additional, Lorger, Mihaela, additional, Massague, Joan, additional, Neman, Josh, additional, Sibson, Nicola, additional, Steeg, Patricia, additional, Thorsen, Frits, additional, Young, Leonie, additional, Vareslija, Damir, additional, Vultur, Adina, additional, Weis-Garcia, Frances, additional, and Winkler, Frank, additional

Published
2020
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42. Redox signals at the ER –mitochondria interface control melanoma progression

Author

Zhang, Xin, primary, Gibhardt, Christine S, additional, Will, Thorsten, additional, Stanisz, Hedwig, additional, Körbel, Christina, additional, Mitkovski, Miso, additional, Stejerean, Ioana, additional, Cappello, Sabrina, additional, Pacheu‐Grau, David, additional, Dudek, Jan, additional, Tahbaz, Nasser, additional, Mina, Lucas, additional, Simmen, Thomas, additional, Laschke, Matthias W, additional, Menger, Michael D, additional, Schön, Michael P, additional, Helms, Volkhard, additional, Niemeyer, Barbara A, additional, Rehling, Peter, additional, Vultur, Adina, additional, and Bogeski, Ivan, additional

Published
2019
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45. Hypoxia-activated prodrug enhances therapeutic effect of sunitinib in melanoma

Author

Liu, Shujing, primary, Tetzlaff, Michael T., additional, Wang, Tao, additional, Chen, Xiang, additional, Yang, Ruifeng, additional, Kumar, Suresh M., additional, Vultur, Adina, additional, Li, Pengxiang, additional, Martin, James S., additional, Herlyn, Meenhard, additional, Amaravadi, Ravi, additional, Li, Bin, additional, and Xu, Xiaowei, additional

Published
2017
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46. A Comprehensive Patient-Derived Xenograft Collection Representing the Heterogeneity of Melanoma

Author

Krepler, Clemens, primary, Sproesser, Katrin, additional, Brafford, Patricia, additional, Beqiri, Marilda, additional, Garman, Bradley, additional, Xiao, Min, additional, Shannan, Batool, additional, Watters, Andrea, additional, Perego, Michela, additional, Zhang, Gao, additional, Vultur, Adina, additional, Yin, Xiangfan, additional, Liu, Qin, additional, Anastopoulos, Ioannis N., additional, Wubbenhorst, Bradley, additional, Wilson, Melissa A., additional, Xu, Wei, additional, Karakousis, Giorgos, additional, Feldman, Michael, additional, Xu, Xiaowei, additional, Amaravadi, Ravi, additional, Gangadhar, Tara C., additional, Elder, David E., additional, Haydu, Lauren E., additional, Wargo, Jennifer A., additional, Davies, Michael A., additional, Lu, Yiling, additional, Mills, Gordon B., additional, Frederick, Dennie T., additional, Barzily-Rokni, Michal, additional, Flaherty, Keith T., additional, Hoon, Dave S., additional, Guarino, Michael, additional, Bennett, Joseph J., additional, Ryan, Randall W., additional, Petrelli, Nicholas J., additional, Shields, Carol L., additional, Terai, Mizue, additional, Sato, Takami, additional, Aplin, Andrew E., additional, Roesch, Alexander, additional, Darr, David, additional, Angus, Steve, additional, Kumar, Rakesh, additional, Halilovic, Ensar, additional, Caponigro, Giordano, additional, Jeay, Sebastien, additional, Wuerthner, Jens, additional, Walter, Annette, additional, Ocker, Matthias, additional, Boxer, Matthew B., additional, Schuchter, Lynn, additional, Nathanson, Katherine L., additional, and Herlyn, Meenhard, additional

Published
2017
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48. The Soldier and the Animal: metaphor in maintenance of antiretroviral adherence in Ghana’s Eastern Region

Author

Akiyama, Matthew J., Napier, David, Bourque, S., Goldberg, A., Boukh-Viner, T., Gregg, C., Kyryakov, P., Chowdhury, S., Titorenko, V.I., Andrews, S.D., Ateeq, B., Torrisani, J., D’Allesio, A.C., Unterberger, A., OU, J-N, McKinney, A., Rabbani, S., Szyf, M., Berger, Robert G., Hancock, Trina, Decatanzaro, Denys, Antonova, Lilia, Mueller, Christopher R., Fong, Jenna, Bañski, Piotr, Kodiha, Mohamed, Stochaj, Ursula, Moheshwarnath, Issur, Bisaillon, Martin, Brisbin, Sarah E., Chin-Sang, Ian D., Ste-Marie, A., Simard, C., Côté, S., Fucile, S, Gisel, E, Erg, Otr, Lau, C, Bourdeau, Annie, Heinonen, Krista M., Doody, Karen M., Higgins, Emily K., Lee-Loy, Ailsa, Tremblay, Michel L., Banski, Piotr, Leduc, F., Maquennehan, V., Nkoma, G. Bikond, Boissonneault, G., Lim, Letitia Z., Hacking, S. A., Li, A., Wang, H., Harvey, E. J., Henderson, J. E., Prefontaine, D., Lajoie-Kadoch, S., Mogas, A.K., Foley, S., Olivenstein, R., Halayko, A.J., Ernst, P., Lemière, C., Martin, J.G., Hamid, Q., McKillop, W. M., Dekaban, G. A., Nguyen, Alana, Beland, Melanie, Gaitan, Yaned, Bouchard, Maxime, Behrmann, Jason, Williams-Jones, Bryn, Hakonarson, Hakon, Grant, Struan F.A., Bradfield, Jonathan P., Marchand, Luc, Kim, Cecilia E., Glessner, Joseph T., Grabs, Rosemarie, Casalunovo, Tracy, Taback, Shayne P., Frackelton, Edward C., Lawson, Margaret L., Robinson, Luke J., Capasso, Mario, Skraban, Robert, Lu, Yang, Chiavacci, Rosetta M., Stanley, Charles A., Kirsch, Susan E., Monos, Dimitri S., Devoto, Marcella, Qu, Hui-Qi, Polychronakos, Constantin, Proulx, Dominic Paquin, Lemieux, Réal, Bazin, Renée, Richard, Nathalie, Tseu, Irene, Post, Martin, Radina, M, Penner, MJ, Smith, RG, Samdup, D, Sebak, Safaa, Mirzaei, Maryam, Malhotra, Meenakshi, Kulamarva, Arun, Prakash, Satya, Tzankov, S., Bhangoo, M. K., Fan, A.C.Y., Young, J.C., Arulanandam, Rozanne, Cao, Jun, Vultur, Adina, Degeer, Jonathan, Larue, Lionel, Feracci, Hélène, Raptis, Leda, Vi, Linda, Gan, Bing Siang, O’gorman, David, Shao, W., and Saleh, M.

Subjects
cell division, implant osseo-integration, caspase-3, Bisphenol-A, heterokaryons, Ghana, Hsp70, stress, VAB-1 Eph Receptor, bone regeneration, protein folding, Rho GTPases, antibodies, implantation, adherence, oncogenic signaling, Hsc70s, polyploidy, genomic integrity, topoisomerase, fertility, shuttling, airway smooth muscle cells, Calcineurin, ADAM12, apoptosis, tyrosine kinase, cell signalling, CnABP, single-nucleotide polymorphism, developmental delay, Type 1 diabetes, cell-cell adhesion, tissue engineering, protein tyrosine phosphatase-1B, confluence, C. elegans, CSLSR Abstracts, pregnancy, interleukin 33, stretch, estrogens, RAS activation, tumour suppressor, antiretroviral therapy, DNA repair, autism, Hsp90, Dupuytren’s Disease, DAF-18/PTEN, Wilms’ tumor, intersferon-gamma, idiopathic toe walking, Hsc70, cytochrome C, megakaryocytes, metastasis, ADHD, chaperones, IGF, nucleoli, nucleolar targeting, epigenetics, uterus, Pax2, Stat3, nucleus, HIV, Krobo, illness narrative, demethylation, asthma, osteoporosis, bronchial biopsies, hematopoiesis, spermiogenesis, T cell protein tyrosine phosphatase, cadherin, blood platelet production, inflammation, genome-wide association, Abstracts from CSLSR, chromatin, accumulation, mitochondrial import
Published
2007

49. Targeting Notch enhances the efficacy of ERK inhibitors in BRAF-V600E melanoma

Author

Krepler, Clemens, primary, Xiao, Min, additional, Samanta, Minu, additional, Vultur, Adina, additional, Chen, Hsin-Yi, additional, Brafford, Patricia, additional, Reyes-Uribe, Patricia I., additional, Halloran, Molly, additional, Chen, Thomas, additional, He, Xu, additional, Hristova, Denitsa, additional, Liu, Qin, additional, Samatar, Ahmed A., additional, Davies, Michael A., additional, Nathanson, Katherine L., additional, Fukunaga-Kalabis, Mizuho, additional, Herlyn, Meenhard, additional, and Villanueva, Jessie, additional

Published
2016
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50. Abstract A02: A novel orthotopic ovarian patient derived xenograft model platform to investigate novel therapies for BRCA deficient ovarian cancers

Author

George, Erin, primary, Kim, Hyoung, additional, Tanyi, Janos, additional, Ragland, Ryan, additional, Brown, Eric, additional, Zhang, Rugang, additional, Brafford, Patricia, additional, Sproesser, Katrin, additional, Beqiri, Marilda, additional, Vultur, Adina, additional, Krepler, Clemens, additional, Weis, Brandon, additional, Nathanson, Kate, additional, Lu, Yuling, additional, Mills, Gordon, additional, Makvandi, Mehran, additional, Mach, Robert, additional, Morgan, Mark, additional, and Simpkins, Fiona, additional

Published
2016
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