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4. Hypertension and migraine comorbidity: prevalence and risk of cerebrovascular events: evidence from a large, multicenter, cross-sectional survey in Italy (MIRACLES study)

Author

Mancia, G, Rosei, Ea, Ambrosioni, E, Avino, F, Carolei, A, Daccã², M, Di Giacomo, G, Ferri, C, Grazioli, I, Melzi, G, Nappi, G, Pinessi, L, Sandrini, G, Trimarco, B, Zanchin, G, MIRACLES Study Group List of collaborators: Rosei EA, Cerbo, R, Del Bene, E, Ferrari, A, Genco, S, Maggioni, F, Malatino, L, Martelletti, P, Nami, R, Palasciano, G, Prudenzano, Mp, Sarchielli, Paola, Volpe, M, Di Iulio, F, Fedele, A, Felli, V, Privitera, G, Abbattista, L, Altieri, A, Bellomo, Mn, Bellomo, P, Bonelli, D, Cappa, G, Cavone, E, De Bellis, A, De Mola, C, De Renzio PA, Di Cecco, G, Di Cosola, V, Di Lecce, G, Di Paola, S, Dileo, Cm, Ferrante, F, Gallo, A, Genchi, A, Grasso, N, Iacobellis, S, Lampugnani, F, Lettini, A, Mancini, A, Mariani, F, Martinelli, G, Martire, A, Mastandrea, A, Miccoli, Ma, Miolli, G, Nicassio, N, Panza, P, Romito, N, Roselli, Gc, Rossi, F, Santoro, G, Saracino, A, Savino, F, Silvestri, C, Stucci, N, Surgo, R, Tarì, G, Turchiano, S, Vigilante, C, Zamparella, M, Bariselli, M, Benedetto, G, Di Mauro, G, Di Pietro, C, Dragone, L, Emiliani, L, Erba, P, Guarnera, L, Maccarrone, R, Mauro, N, Palumbo, M, Pizzo, S, Quaggiotti, E, Rigoni, F, Romano, M, Rondi, G, Rossi, A, Tabaglio, E, Trapelli, F, Verzura, P, Zammarchi, G, Zecchi, F, Zucchi, R, Alessi, A, Bacci, E, Bianucci, S, Falorni, F, Foppa, L, Frati, A, Hili, Jl, Mij, R, Negro, P, Niccolini, N, Pini, C, Santangeli, S, Schirripa, E, Serni, R, Zucconi, E, Bartolomucci, M, Bontempo, F, Calegaro, E, Chiarinelli, M, Ciccarella, A, De Mattia, C, D'Innocenzo, C, Evangelista, P, Giammaria, A, Gizzi, M, Laglia, G, Lupi, R, Masciovecchio, L, Nattellis, A, Zugaro, A, Barbieri, G, Bellentani, G, Bertoli, R, Bolognesi, Mg, Borghi, R, Bronzini, G, Cassanelli, M, Cirsone, R, D'Urso, Ar, Gallina, Mp, Giroldi, L, Iancu, G, Mai, Mp, Manfredonia, M, Nappi, E, Onesti, L, Pini, P, Rubbiani, B, Sacco, R, Tripodi, A, Verna, A, Zini, C, Aldrigo, L, Bertamini, A, Bossone, V, Bovo, P, Bovo, R, Bozza, F, Danieli, M, Doriguzzi, Ma, Eifu', G, Fragasso, A, Francheo, R, Mayellaro, V, Moro, A, Rubiconi, D, Russo, S, Ventura, A, Zoccali, R, Abbate, G, Arcangelo, A, Battaglia, T, Buccoleri, G, Cardinale, C, Cardinale, G, D'Agati, P, D'Alessandro, R, Di Carlo, V, Di Garbo, V, Favuzza, M, Giovenco, E, Liberti, G, Mauceri, Ml, Miallo, C, Progno, Ma, Quartetti, G, Scimeca, S, Enrico, S, Spatafora, V, Spera, G, Viola, V, Vultaggio, G, Above, L, Ammirati, G, Barone, D, Brizzi, P, Callegari, S, Casari, G, Coronelli, M, Daccò, M, Deodato, D, Fortunato, A, Gabba, F, Grimaldi, D, Menini, M, Musolino, A, Negri, F, Orlandi, E, Pisani, G, Quattrocchi, P, Baglioni, G, Benedetti, W, Bensi, A, Berardi, M, Birgolotti, Mc, Buresta, R, Cimignoli, E, Coppini, B, Draghini, L, Germini, F, Grilli, P, Lindi, S, Mezzetti, S, Natali, R, Pannacci, V, Parretti, D, Petrelli, S, Scarponi, T, Sgrelli, V, Surace, Ma, Susta, A, Tedeschi, L, Urbani, A, Bennardo, S, Bitetti, R, Burgio, R, Caccamo, G, Cottonaro, C, Di Pasquale, S, Di Stefano, S, Drago, G, Gurrieri, G, La Rosa, F, La Terra Bella, B, Ottaviano, G, Ottaviano, V, Ruta, G, Sortino, F, Tidona, F, Tumino, A, Tumino, G, Tumino, M, Vitale, G, Maria Zelante RF, Annibali, A, Antognoli, L, Antonelli, P, Arcadi, Re, Bartolini, A, Bruschelli, C, Calvieri, A, Domeniconi, P, Fiumana, M, Frittaion, F, Lazzaro, M, Leardi, F, Leoni, M, Marini, G, Marri, G, Massari, R, Mazzei, N, Mocci, B, Mocci, M, Morelli, A, Nati, G, Sebastiano, Orifici, Maria Luisa Paoletti, Maurizio, Parisi, Massimo, Pergolini, Italo, Polce, Stefano Roberto Polce, Paolo, Questino, Francesco, Rossiello, Massimo, Sabatini, Tiziana, Volpe, Agnello, M, Antonaci, L, Antonucci, P, Avaltroni, R, Barbaro, N, Bartolone, L, Bertini, Ma, Blasi, P, Bruziches, V, Cannata, P, Cannone, A, Capuano, C, Carbonetti, M, Cianfriglia, S, Fanelli, R, Fazi, F, Gambioli, S, Giannini, M, Giannone, M, Guerriero, G, Lanza, L, Latino, C, Leporelli, M, Maresca, G, Matzuzzi, G, Milani, L, Mocci, A, Muccichini, L, Oliva, F, Palange, Ma, Pratticò, C, Re, M, Sagoni, E, Salciccia, S, Sciarretta, A, Silvi, C, Tranò, F, Tripiciano, P, Troccoli, A, Troysi, S, Ansaldi, S, Anselmi, F, Bianchini, C, Carletti, F, De Michelis, R, De Risi, E, Faglia, S, Fracassi, L, Franci, A, Lenzi, G, Loretti, M, Marchetti, F, Marrelli, G, Martellini, A, Moretti, A, Pieragalli, L, Sani, P, Scibilia, G, and Turillazzi, P.

Published
2011

9. Concomitant cyclophosphamide, doxorubicin, vincristine, and prednisone chemotherapy plus highly active antiretroviral therapy in patients with human immunodeficiency virus-related, non-Hodgkin lymphoma.

Author

Vaccher, Emanuela, Spina, Michele, di Gennaro, Giampiero, Talamini, Renato, Nasti, Guglielmo, Schioppa, Ornella, Vultaggio, Giuseppe, Tirelli, Umberto, Vaccher, E, Spina, M, di Gennaro, G, Talamini, R, Nasti, G, Schioppa, O, Vultaggio, G, and Tirelli, U

Published
2001
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10. Gestione e sviluppo locale

Author

TRAPANI, Ferdinando, Leone NG, Aprile, M, Badami, A, Barone, A, Bini, G, Bonafede, G, Cernigliaro, F, Dalla Vecchia, M, Dara Guccione, G, Dragotto, T, Fazio, G, Foderà, L, Giuffrè, T, Imbesi, G, Italia, A, Lagalla, R, Lamponi, A, Li Vigni, VP, Longobardi, M, Lozato-Giotart, JP, Mauro, E, Messana, P, Missineo, S, Naselli, F, Panzarella, A, Persico, P, Purpura, A, Quartarone, C, Raimondo, L, Ruggieri Foderà, RM, Ruggiriello, D, Schiavo, F, Tilotta, V, Tranchida, G, Trapani, F, Tusa, S, Urbani, L, and Vultaggio, G

Subjects
turismo sostenibile, sviluppo locale, turismo e territorio, Settore ICAR/21 - Urbanistica
Abstract

Nel saggio curato da Ferdinando Trapani affronta aspetti che legano il problema della gestione turistica delle risorse locali dal punto di vista della programmazione che della pianificazione dello sviluppo territoriale. Il contributo di Ferdinando Trapani affronta una riflessione sulla problematica della gestione nel rapporto tra domanda e offerta turistica.

Published
2013

11. Estrogen receptor alpha mRNA variant lacking exon 5 is co-expressed with the wild-type in endometrial adenocarcinoma

Author

Ilva Ferretti, Giuseppe Vultaggio, Lorenza Driul, Luigi Cobellis, Erica Villa, Felice Petraglia, Fernando M. Reis, Cobellis, Luigi, Reis, Fm, Driul, L, Vultaggio, G, Ferretti, I, Villa, E, and Petraglia, F.

Subjects
Adult, medicine.medical_specialty, medicine.drug_class, Biopsy, endometrial adenocarcinoma, Gene Expression, Estrogen receptor, Hysteroscopy, Adenocarcinoma, Biology, Endometrium, Exon, Internal medicine, Endometrial adenocarcinoma, medicine, Humans, RNA, Messenger, Receptor, Aged, Aged, 80 and over, medicine.diagnostic_test, Reverse Transcriptase Polymerase Chain Reaction, estrogen receptor, Endometrial cancer, Estrogen Receptor alpha, Genetic Variation, Obstetrics and Gynecology, Exons, Middle Aged, medicine.disease, Molecular biology, Endometrial Neoplasms, Alternative Splicing, medicine.anatomical_structure, Endocrinology, Receptors, Estrogen, Reproductive Medicine, Estrogen, Female, Endometrial biopsy
Abstract

Background : Endometrial adenocarcinoma is a typical estrogen-dependent neoplasia. The molecular mechanisms underlying carcinogenesis in the endometrium are still largely unknown. Recently, estrogen receptor (ER) mRNA splicing variants have been investigated in several normal and neoplastic human tissues. It has been suggested that the variant receptors compete with the wild-type receptors and thereby modulate the effects of estrogens and related steroids. Objective : To investigate the possible expression of the ER α mRNA variant-type lacking exon 5 (ERΔ5) in endometrial adenocarcinoma and peritumoral tissues, non-neoplastic endometrium of healthy women served as control. Study design : The study included 16 patients divided in two groups. The first group ( n =6) was submitted to hysteroscopy and endometrial biopsy for metrorrhage, showing normal proliferative ( n =2) or secretory ( n =4) endometrium, the second group ( n =10) included patients submitted to hysterectomy for endometrial adenocarcinoma (stages Ib–IIIb). In this latter group, specimens from peritumoral tissues were also analyzed ( n =3). Characterization of the variant and wild-type α estrogen receptor transcripts was performed by RT-PCR with primers located in exons 4 and 6, followed by southern hybridization with probes directed to a specific 29 nucleotide sequence of exon 6, internal to the amplified fragments. Results : The ER α mRNA variant was co-expressed with the wild-type ER in five or six samples of non-neoplastic endometrium and in 10/10 cases of adenocarcinoma, with a more intense hybridization signal corresponding to the wild-type 439 bp band compared to the variant-type 300 bp band. Specimens from peritumoral tissue also expressed the variant ERΔ5 along with wild-type ER. Conclusion : The presence of α mRNA variant lacking exon 5 in both normal and endometrial adenocarcinoma do not support a major role of variant estrogens receptors in the biology of endometrial cancer.

Published
2002

12. Estrogen receptor alpha mRNA variant lacking exon 5 is co-expressed with the wild-type in endometrial adenocarcinoma.

Author

Cobellis L, Reis FM, Driul L, Vultaggio G, Ferretti I, Villa E, and Petraglia F

Subjects
Adenocarcinoma pathology, Adenocarcinoma surgery, Adult, Aged, Aged, 80 and over, Alternative Splicing, Biopsy, Endometrial Neoplasms pathology, Endometrial Neoplasms surgery, Endometrium chemistry, Endometrium pathology, Estrogen Receptor alpha, Female, Humans, Hysteroscopy, Middle Aged, RNA, Messenger analysis, Reverse Transcriptase Polymerase Chain Reaction, Adenocarcinoma genetics, Endometrial Neoplasms genetics, Exons, Gene Expression, Genetic Variation, Receptors, Estrogen genetics
Abstract

Background: Endometrial adenocarcinoma is a typical estrogen-dependent neoplasia. The molecular mechanisms underlying carcinogenesis in the endometrium are still largely unknown. Recently, estrogen receptor (ER) mRNA splicing variants have been investigated in several normal and neoplastic human tissues. It has been suggested that the variant receptors compete with the wild-type receptors and thereby modulate the effects of estrogens and related steroids., Objective: To investigate the possible expression of the ER alpha mRNA variant-type lacking exon 5 (ERDelta5) in endometrial adenocarcinoma and peritumoral tissues, non-neoplastic endometrium of healthy women served as control., Study Design: The study included 16 patients divided in two groups. The first group (n=6) was submitted to hysteroscopy and endometrial biopsy for metrorrhage, showing normal proliferative (n=2) or secretory (n=4) endometrium, the second group (n=10) included patients submitted to hysterectomy for endometrial adenocarcinoma (stages Ib-IIIb). In this latter group, specimens from peritumoral tissues were also analyzed (n=3). Characterization of the variant and wild-type alpha estrogen receptor transcripts was performed by RT-PCR with primers located in exons 4 and 6, followed by southern hybridization with probes directed to a specific 29 nucleotide sequence of exon 6, internal to the amplified fragments., Results: The ER alpha mRNA variant was co-expressed with the wild-type ER in five or six samples of non-neoplastic endometrium and in 10/10 cases of adenocarcinoma, with a more intense hybridization signal corresponding to the wild-type 439bp band compared to the variant-type 300bp band. Specimens from peritumoral tissue also expressed the variant ERDelta5 along with wild-type ER., Conclusion: The presence of alpha mRNA variant lacking exon 5 in both normal and endometrial adenocarcinoma do not support a major role of variant estrogens receptors in the biology of endometrial cancer.

Published
2002
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13. Failure of detection of the tyrosine to histidine substitution at the residue 33 of thymidylate synthase in human colorectal cancer. A preliminary study.

Author

Sanguedolce R, Alessandro R, De Leo G, Gullotti L, Sanguedolce F, Vultaggio G, Diana G, Cirello B, and Rausa L

Subjects
Adenocarcinoma enzymology, Adenocarcinoma genetics, Adenocarcinoma pathology, Aged, Colonic Neoplasms enzymology, Colonic Neoplasms pathology, Female, Histidine, Humans, Male, Neoplasm Staging, Rectal Neoplasms enzymology, Rectal Neoplasms pathology, Reverse Transcriptase Polymerase Chain Reaction, Tyrosine, Colonic Neoplasms genetics, Neoplasm Proteins genetics, Point Mutation, Rectal Neoplasms genetics, Thymidylate Synthase genetics
Abstract

Structural changes in the macromolecular targets of pharmacological agents can result in alterations in the efficacy of these agents. In previous studies Berger et al. (1) identified a variant structural form of thymidylate synthase (TS) that is associated with relative resistance to 5-fluoro-2'-deoxyuridine, in a human colonic tumor cell line. They observed that expression of the variant TS, which differs from the normal form by a tyrosine to histidine substitution at residue 33, confers a 4-fold level of drug resistance in mammalian cells, as well as in bacteria. Now we report on the use of RT-PCR techniques to see if that variant TS form could be present in human samples from patients who underwent surgery for primary colorectal cancer and been previously untreated and to try to find relationships between that hypothetical variant TS form and the 5-Fluorouracil treatment. The possible role of Tyr-33 in 5-fluoropyrimidine-mediated inhibition of TS is discussed.

Published
2000

14. The role of thymidylate synthase levels in the prognosis and the treatment of patients with colorectal cancer.

Author

Sanguedolce R, Vultaggio G, Sanguedolce F, Modica G, Li Volsi F, Diana G, Guereio G, Bellanca L, and Rausa L

Subjects
Adenocarcinoma enzymology, Adenocarcinoma mortality, Adenocarcinoma pathology, Aged, Biomarkers, Tumor analysis, Colorectal Neoplasms enzymology, Colorectal Neoplasms mortality, Colorectal Neoplasms pathology, Female, Humans, Intestinal Mucosa enzymology, Intestinal Mucosa pathology, Male, Middle Aged, Neoplasm Staging, Prognosis, Survival Rate, Thymidylate Synthase analysis, Time Factors, Adenocarcinoma surgery, Colorectal Neoplasms surgery, Thymidylate Synthase metabolism
Abstract

Inhibition of Thymidylate Synthase (TS) by the 5-Fluorouracil (5Fu) active metabolite Fluoro-deoxy-uridine-monophosphate (FdUMP) is considered to be the main mechanism of action of 5Fu. TS level from tumors and normal mucosa of 62 untreated patients who underwent surgery for primary colorectal adenocarcinoma was performed. The aim of this study was to evaluate the possibility of considering the TS level as a prognostic factor of the disease. A large variation in the level of the enzyme was found among tumors. Our data demonstrate that there is no association with age, sex, and tumor size; however there are significant relationships between TS levels and staging and histological grading. In fact the TS values are higher in Dukes' A and in G1 than in Dukes' D and G3 tumors (p < 0.05). Another significant association has been found between the TS level and tumor site: pts with right colon neoplasias had higher TS levels than pts with left and rectum ones. An interesting trend was found between the TS levels and survival parameters. Pts who had lower TS levels had a significantly increased risk of death (p < 0.05) over pts with a higher outcome. Our data support the hypothesis that a high TS level is a favourable prognostic factor in human untreated colorectal carcinomas according to our previous preliminary data (1).

Published
1998

15. Thymidylate synthase level and DNA-ploidy pattern as possible prognostic factors in human colorectal cancer: a preliminary study.

Author

Sanguedolce R, Brumarescu I, Dardanoni G, Grassadonia A, Vultaggio G, and Rausa L

Subjects
Adenocarcinoma metabolism, Adenocarcinoma mortality, Adenocarcinoma surgery, Age Factors, Aged, Aneuploidy, Colorectal Neoplasms metabolism, Colorectal Neoplasms mortality, Colorectal Neoplasms surgery, DNA, Neoplasm genetics, Diploidy, Disease-Free Survival, Female, Humans, Male, Middle Aged, Neoplasm Staging, Predictive Value of Tests, Prognosis, Sex Characteristics, Survival Rate, Thymidylate Synthase metabolism, Adenocarcinoma pathology, Colorectal Neoplasms pathology, DNA, Neoplasm analysis, Ploidies, Thymidylate Synthase analysis
Abstract

5-Fluorouracil is the drug chosen for the treatment of patients with advanced colorectal carcinoma; its major site of action is thymidylate synthase (TS), resulting in pronounced and prolonged inhibition of DNA synthesis. The aim of this study was to evaluate the possibility of considering TS level in human colorectal carcinomas of previously untreated patients (pts) as a prognostic factor. Our data demonstrate that there is no association with age, sex, tumor site and tumor size; however, there is a relationship between TS levels and staging: in fact, the TS values are higher (P < 0.05) in Dukes-A tumors than in the others. A significant association was also found between the TS levels and survival parameters: in fact, pts with longer disease-free and overall survivals had a significantly increased TS level compared to pts with a poorer outcome (P < 0.05). Moreover, pts with DNA-aneuploid tumors had lower TS level (median = 0.044 pmol/mg protein) than diploid pts who had higher TS level (median = 0.093 pmol/mg protein); however the difference is not significant. Our result are based on preliminary data; however, they seem to support the hypothesis that a high TS level is a favourable prognostic factor in human colorectal carcinoma.

Published
1995

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