589 results on '"Vukusic S"'
Search Results
2. Caractéristiques neurologiques de la sclérose en plaque associée à une uvéite : étude cas témoins monocentrique
- Author
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Gil, W., primary, Chacun, S., additional, Androdias, G., additional, Vasseneix, C., additional, Kodjikian, L., additional, El Jammal, T., additional, Vukusic, S., additional, and Sève, P., additional
- Published
- 2024
- Full Text
- View/download PDF
3. P26 - Risque de poussée après vaccination contre le COVID-19 chez les patients atteints de sclérose en plaques en France utilisant un design « self-controlled case series »
- Author
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Mulliez, A., primary, Moisset, X., additional, Chenaf, C., additional, Taithe, F., additional, Vukusic, S., additional, and Leray, E., additional
- Published
- 2024
- Full Text
- View/download PDF
4. Recommandations de la Société Francophone de la Sclérose en Plaques : grossesse et sclérose en plaques
- Author
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Vukusic, S. and Lebrun-Frénay, C.
- Published
- 2022
- Full Text
- View/download PDF
5. Recommandations de la Société francophone de la sclérose en plaques : grossesse et maladies du spectre NMO
- Author
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Vukusic, S. and Lebrun-Frénay, C.
- Published
- 2022
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- View/download PDF
6. Impact of methodological choices in comparative effectiveness studies: application in natalizumab versus fingolimod comparison among patients with multiple sclerosis
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Lefort, M., Sharmin, S., Andersen, J. B., Vukusic, S., Casey, R., Debouverie, M., Edan, G., Ciron, J., Ruet, A., De Sèze, J., Maillart, E., Zephir, H., Labauge, P., Defer, G., Lebrun-Frenay, C., Moreau, T., Berger, E., Clavelou, P., Pelletier, J., Stankoff, B., Gout, O., Thouvenot, E., Heinzlef, O., Al-Khedr, A., Bourre, B., Casez, O., Cabre, P., Montcuquet, A., Wahab, A., Camdessanché, J. P., Maurousset, A., Ben Nasr, H., Hankiewicz, K., Pottier, C., Maubeuge, N., Dimitri-Boulos, D., Nifle, C., Laplaud, D. A., Horakova, D., Havrdova, E. K., Alroughani, R., Izquierdo, G., Eichau, S., Ozakbas, S., Patti, F., Onofrj, M., Lugaresi, A., Terzi, M., Grammond, P., Grand’Maison, F., Yamout, B., Prat, A., Girard, M., Duquette, P., Boz, C., Trojano, M., McCombe, P., Slee, M., Lechner-Scott, J., Turkoglu, R., Sola, P., Ferraro, D., Granella, F., Shaygannejad, V., Prevost, J., Maimone, D., Skibina, O., Buzzard, K., Van der Walt, A., Karabudak, R., Van Wijmeersch, B., Csepany, T., Spitaleri, D., Vucic, S., Koch-Henriksen, N., Sellebjerg, F., Soerensen, P. S., Hilt Christensen, C. C., Rasmussen, P. V., Jensen, M. B., Frederiksen, J. L., Bramow, S., Mathiesen, H. K., Schreiber, K. I., Butzkueven, H., Magyari, M., Kalincik, T., and Leray, E.
- Published
- 2022
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7. Pregnancy with multiple sclerosis
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Vukusic, S., Michel, L., Leguy, S., and Lebrun-Frenay, C.
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- 2021
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8. MRI characteristics of MOG-Ab associated disease in adults: An update
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Shor, N., Deschamps, R., Cobo Calvo, A., Maillart, E., Zephir, H., Ciron, J., Papeix, C., Durand-Dubief, F., Ruet, A., Ayrignac, X., Cohen, M., Deiva, K., Laplaud, D., Bourre, B., Audoin, B., Collongues, N., Vukusic, S., Cotton, F., and Marignier, R.
- Published
- 2021
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- View/download PDF
9. Artificial intelligence to predict clinical disability in patients with multiple sclerosis using FLAIR MRI
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Brochet, B., Casey, R., Cotton, F., De Sèze, J., Douek, P., Guillemin, F., Laplaud, D., Lebrun-Frenay, C., Mansuy, L., Moreau, T., Olaiz, J., Pelletier, J., Rigaud-Bully, C., Stankoff, B., Vukusic, S., Marignier, R., Debouverie, M., Edan, G., Ciron, J., Ruet, A., Collongues, N., Lubetzki, C., Vermersch, P., Labauge, P., Defer, G., Cohen, M., Fromont, A., Wiertlewsky, S., Berger, E., Clavelou, P., Audoin, B., Giannesini, C., Gout, O., Thouvenot, E., Heinzlef, O., Al-Khedr, A., Bourre, B., Casez, O., Cabre, P., Montcuquet, A., Créange, A., Camdessanché, J.-P., Faure, J., Maurousset, A., Patry, I., Hankiewicz, K., Pottier, C., Maubeuge, N., Labeyrie, C., Nifle, C., Ameli, R., Anxionnat, R., Attye, A., Bannier, E., Barillot, C., Ben Salem, D., Boncoeur-Martel, M.-P., Bonneville, F., Boutet, C., Brisset, J.-C., Cervenanski, F., Claise, B., Commowick, O., Constans, J.-M., Dardel, P., Desal, H., Dousset, Vincent, Durand-Dubief, F., Ferre, J.-C., Gerardin, E., Glattard, T., Grand, S., Grenier, T., Guillevin, R., Guttmann, C., Krainik, A., Kremer, S., Lion, S., Menjot de Champfleur, N., Mondot, L., Outteryck, O., Pyatigorskaya, N., Pruvo, J.-P., Rabaste, S., Ranjeva, J.-P., Roch, J.-A., Sadik, J.C., Sappey-Marinier, D., Savatovsky, J., Tanguy, J.-Y., Tourbah, A., Tourdias, T., Roca, P., Colas, L., Tucholka, A., Rubini, P., Cackowski, S., Ding, J., Budzik, J.-F., Renard, F., Doyle, S., Barbier, E.L., Bousaid, I., Lassau, N., and Verclytte, S.
- Published
- 2020
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10. Urinary tract infections and multiple sclerosis: Recommendations from the French Multiple Sclerosis Society
- Author
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Donzé, C., Papeix, C., Lebrun-Frénay, C., Collongues, N., de Seze, M., Dinh, A., Even, A., Scheiber-Nogueira, C., Bensa, C., Bourre, B., Carra-Dallière, C., Ciron, J., Cohen, M., Guennoc, A.M., Louapre, C., Lebreton, F., Michel, L., Maillart, E., Audoin, B., Ayrignac, X., Bernady, P., Brochet, B., Clavelou, P., Colamarino, R., Declemy, A., de Seze, J., Derache, N., Faucheux, J.-M., Heinzlef, O., Labauge, P., Laplaud, D., Lepage, E., Leray, E., Magy, L., Mathey, G., Mekies, C., Mondain, V., Planque, E., Pelletier, J., Pittion, S., Stankhof, B., Tournaire, P., Thouvenot, E., Vukusic, S., Wiertlevski, S., Zephir, H., Alchaar, H., Androdias, G., Benazet, M., Bensmail, D., Biotti, D., Blanchard-Dauphin, A., Bonnan, M., Boutière, C., Branger, P., Bresch, S., Bru, J.-P., Camdessanché, J.-P., Castel Canal, E., Coustans, M., Casez, O., Castan, B., Creange, A., Creisson, E., De Broucker, T., Depaz, R., Douay, X., Dulau, C., Durand-Dubief, F., Fagniez, O., Faucher, M., Floch, A., Fournier, M., Fromont, A., Gallien, P., Gamé, X., Gault, D., Gayou, A., Giroux, M., Gout, O., Grimaud, J., Hautecoeur, P., Kerbrat, A., Kremer, L., Kwiatkowski, A., Labeyrie, C., Lachaud, S., Lanctin-Garcia, C., Lanotte, L., Manchon, E., Maurousset, A., Milor, A.-M., Moisset, X., Mont-Cuquet, A., Moreau, T., Ouallet, J.-C., Patry, I., Peaureaux, D., Pouget, M.-C., Pourcher Martinez, V., Radot, C., Ruet, A., Saint-Val, C., Salmon, A., Taithe, F., Tatevin, P., Vaillant, M., Stahl, J.-P., Vuoto, F., Zaenker, C., and Lebrun-Frenay, C.
- Published
- 2020
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11. Recommandations de la Société francophone de la sclérose en plaques « Vaccinations et Sclérose En Plaques » : aspects pratiques
- Author
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Lebrun-Frénay, C., Mathey, G., Casez, O., Cohen, M., Rico-Lamy, A., Pourcher, V., and Vukusic, S.
- Published
- 2019
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12. Immunization and multiple sclerosis: Recommendations from the French Multiple Sclerosis Society
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Abadie, V., Achour, C., Ader, F., Alchaar, H., Alkhedr, A., Andreux, F., Androdias, G., Arjmand, R., Audoin, B., Audry, D., Aufauvre, D., Autreaux, C., Ayrignac, X., Bailbe, M., Benazet, M., Bensa, C., Bensmail, D., Berger, E., Bernady, P., Bertagna, Y., Biotti, D., Blanchard-Dauphin, A., Bonenfant, J., Bonnan, M., Bonnemain, B., Borgel, F., Botelho-Nevers, E., Boucly, S., Bourre, B., Boutière, C., Branger, P., Brassat, D., Bresch, S., Breuil, V., Brochet, B., Brugeilles, H., Bugnon, P., Cabre, P., Camdessanché, J.-P., Carra-Dalière, C., Casez, O., Chamouard, J.-M., Chassande, B., Chataignier, P., Chbicheb, M., Chenet, A., Ciron, J., Clavelou, P., Cohen, M., Colamarino, R., Collongues, N., Coman, I., Corail, P.-R., Courtois, S., Coustans, M., Creange, A., Creisson, E., Daluzeau, N., Davenas, C., De Seze, J., Debouverie, M., Depaz, R., Derache, N., Divio, L., Douay, X., Dulau, C., Durand-Dubief, F., Edan, G., Elias, Z., Fagniez, O., Faucher, M., Faucheux, J.-M., Fournier, M., Gagneux-Brunon, A., Gaida, P., Galli, P., Gallien, P., Gaudelus, J., Gault, D., Gayou, A., Genevray, M., Gentil, A., Gere, J., Gignoux, L., Giroux, M., Givron, P., Gout, O., Grimaud, J., Guennoc, A.-M., Hadhoum, N., Hautecoeur, P., Heinzlef, O., Jaeger, M., Jeannin, S., Kremer, L., Kwiatkowski, A., Labauge, P., Labeyrie, C., Lachaud, S., Laffont, I., Lanctin-Garcia, C., Lannoy, J., Lanotte, L., Laplaud, D., Latombe, D., Lauxerois, M., Le Page, E., Lebrun-Frenay, C., Lejeune, P., Lejoyeux, P., Lemonnier, B., Leray, E., Loche, C.-M., Louapre, C., Lubetzki, C., Maarouf, A., Mada, B., Magy, L., Maillart, E., Manchon, E., Marignier, R., Marque, P., Mathey, G., Maurousset, A., Mekies, C., Merienne, M., Michel, L., Milor, A.-M., Moisset, X., Montcuquet, A., Moreau, T., Morel, N., Moussa, M., Naudillon, J.-P., Normand, M., Olive, P., Ouallet, J.-C., Outteryck, O., Pacault, C., Papeix, C., Patry, I., Peaureaux, D., Pelletier, J., Pichon, B., Pittion, S., Planque, E., Pouget, M.-C., Pourcher, V., Radot, C., Robert, I., Rocher, F., Ruet, A., Saint-Val, C., Salle, J.-Y., Salmon, A., Sartori, E., Schaeffer, S., Stankhof, B., Taithe, F., Thouvenot, E., Tizon, C., Tourbah, A., Tourniaire, P., Vaillant, M., Vermersch, P., Vidil, S., Wahab, A., Warter, M.-H., Wiertlewski, S., Wiplosz, B., Wittwer, B., Zaenker, C., Zephir, H., Lebrun, C., and Vukusic, S.
- Published
- 2019
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13. Multiple sclerosis registries in Europe – An updated mapping survey
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Glaser, A., Stahmann, A., Meissner, T., Flachenecker, P., Horáková, D., Zaratin, P., Brichetto, G., Pugliatti, M., Rienhoff, O., Vukusic, S., de Giacomoni, A.C., Battaglia, M.A., Brola, W., Butzkueven, H., Casey, R., Drulovic, J., Eichstädt, K., Hellwig, K., Iaffaldano, P., Ioannidou, E., Kuhle, J., Lycke, K., Magyari, M., Malbaša, T., Middleton, R., Myhr, K.M., Notas, K., Orologas, A., Otero-Romero, S., Pekmezovic, T., Sastre-Garriga, J., Seeldrayers, P., Soilu-Hänninen, M., Stawiarz, L., Trojano, M., Ziemssen, T., Hillert, J., and Thalheim, C.
- Published
- 2019
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14. Recommendations for the use of Rituximab in neuromyelitis optica spectrum disorders
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Ciron, J., Audoin, B., Bourre, B., Brassat, D., Durand-Dubief, F., Laplaud, D., Maillart, E., Papeix, C., Vukusic, S., Zephir, H., Marignier, R., and Collongues, N.
- Published
- 2018
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15. Historique de la sclérose en plaques
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Defer, Gilles, primary, Debouverie, Marc, additional, Bardou, I., additional, Benamar, M., additional, Bernard-Valnet, R., additional, Branger, P., additional, Brassat, D., additional, Benallègue, N., additional, Calocer, F., additional, Damotte, V., additional, Dejardin, O., additional, Dejean, A., additional, Derache, N., additional, Docagne, F., additional, Donzé, C., additional, Dubessy, A.-L., additional, Fontaine, B., additional, Fournié, G., additional, Fromont, A., additional, Garcia, A., additional, Hautecœur, P., additional, Lanotte, L., additional, Laplaud, D., additional, Le Mauff, B., additional, Lebas, H., additional, Leray, E., additional, Mathey, G., additional, Merkler, D., additional, Michel, L., additional, Michieletto, M., additional, Morille, J., additional, Nicol, B., additional, Pierrot-Deseilligny, C., additional, Pittion-Vouyovitch, S., additional, Rebeix, I., additional, Saoudi, A., additional, Seilhean, D., additional, Stankoff, B., additional, Toutirais, O., additional, Vivien, D., additional, and Vukusic, S., additional
- Published
- 2019
- Full Text
- View/download PDF
16. Immunologie de la sclérose en plaques
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Defer, Gilles, primary, Debouverie, Marc, additional, Bardou, I., additional, Benamar, M., additional, Bernard-Valnet, R., additional, Branger, P., additional, Brassat, D., additional, Benallègue, N., additional, Calocer, F., additional, Damotte, V., additional, Dejardin, O., additional, Dejean, A., additional, Derache, N., additional, Docagne, F., additional, Donzé, C., additional, Dubessy, A.-L., additional, Fontaine, B., additional, Fournié, G., additional, Fromont, A., additional, Garcia, A., additional, Hautecœur, P., additional, Lanotte, L., additional, Laplaud, D., additional, Le Mauff, B., additional, Lebas, H., additional, Leray, E., additional, Mathey, G., additional, Merkler, D., additional, Michel, L., additional, Michieletto, M., additional, Morille, J., additional, Nicol, B., additional, Pierrot-Deseilligny, C., additional, Pittion-Vouyovitch, S., additional, Rebeix, I., additional, Saoudi, A., additional, Seilhean, D., additional, Stankoff, B., additional, Toutirais, O., additional, Vivien, D., additional, and Vukusic, S., additional
- Published
- 2019
- Full Text
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17. Épidémiologie, environnement et génétique dans la sclérose en plaques
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Defer, Gilles, primary, Debouverie, Marc, additional, Bardou, I., additional, Benamar, M., additional, Bernard-Valnet, R., additional, Branger, P., additional, Brassat, D., additional, Benallègue, N., additional, Calocer, F., additional, Damotte, V., additional, Dejardin, O., additional, Dejean, A., additional, Derache, N., additional, Docagne, F., additional, Donzé, C., additional, Dubessy, A.-L., additional, Fontaine, B., additional, Fournié, G., additional, Fromont, A., additional, Garcia, A., additional, Hautecœur, P., additional, Lanotte, L., additional, Laplaud, D., additional, Le Mauff, B., additional, Lebas, H., additional, Leray, E., additional, Mathey, G., additional, Merkler, D., additional, Michel, L., additional, Michieletto, M., additional, Morille, J., additional, Nicol, B., additional, Pierrot-Deseilligny, C., additional, Pittion-Vouyovitch, S., additional, Rebeix, I., additional, Saoudi, A., additional, Seilhean, D., additional, Stankoff, B., additional, Toutirais, O., additional, Vivien, D., additional, and Vukusic, S., additional
- Published
- 2019
- Full Text
- View/download PDF
18. Histoire naturelle de la sclérose en plaques
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Defer, Gilles, primary, Debouverie, Marc, additional, Bardou, I., additional, Benamar, M., additional, Bernard-Valnet, R., additional, Branger, P., additional, Brassat, D., additional, Benallègue, N., additional, Calocer, F., additional, Damotte, V., additional, Dejardin, O., additional, Dejean, A., additional, Derache, N., additional, Docagne, F., additional, Donzé, C., additional, Dubessy, A.-L., additional, Fontaine, B., additional, Fournié, G., additional, Fromont, A., additional, Garcia, A., additional, Hautecœur, P., additional, Lanotte, L., additional, Laplaud, D., additional, Le Mauff, B., additional, Lebas, H., additional, Leray, E., additional, Mathey, G., additional, Merkler, D., additional, Michel, L., additional, Michieletto, M., additional, Morille, J., additional, Nicol, B., additional, Pierrot-Deseilligny, C., additional, Pittion-Vouyovitch, S., additional, Rebeix, I., additional, Saoudi, A., additional, Seilhean, D., additional, Stankoff, B., additional, Toutirais, O., additional, Vivien, D., additional, and Vukusic, S., additional
- Published
- 2019
- Full Text
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19. Comment je gère un traitement par natalizumab au-delà de la 24e cure
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Androdias, G. and Vukusic, S.
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- 2015
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20. Coexistence of flavum ligament ossification with diffuse idiopathic skeletal hyperostosis in the cervical spine: Review of literature and technical note starting from a rare case
- Author
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Calvanese, F., primary, Capo, G., additional, Picart, T., additional, Durieux, E., additional, Vukusic, S., additional, Di Carlo, D., additional, and Barrey, C.Y., additional
- Published
- 2022
- Full Text
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21. Recycling of Cross-linked Polyethylene Cable Waste via Particulate Infusion
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Qudaih, R., Janajreh, I., Vukusic, S. E., Seliger, Günther, editor, Khraisheh, Marwan M.K., editor, and Jawahir, I.S., editor
- Published
- 2011
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22. Intramedullary abscess secondary to infective endocarditis presenting as longitudinally extensive transverse myelopathy
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Theuriet, J., primary, Richard, C., additional, Cotton, F., additional, Vukusic, S., additional, and Marignier, R., additional
- Published
- 2022
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23. Étude rétrospective multicentrique de 15 cas adultes de xanthomatose cérébrotendineuse : aspects cliniques et paracliniques typiques et atypiques
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Lionnet, C., Carra, C., Ayrignac, X., Levade, T., Gayraud, D., Castelnovo, G., Besson, G., Androdias, G., Vukusic, S., Confavreux, C., Zaenker, C., De Seze, J., Collongues, N., Blanc, F., Tranchant, C., Wallon, D., Hannequin, D., Gerdelat-Mas, A., Brassat, D., Clanet, M., Zephir, H., Outteryck, O., Vermersch, P., and Labauge, P.
- Published
- 2014
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24. Infarctus bulbaire paramédian bilatéral d’évolution progressive : à propos de deux cas documentés en imagerie par résonance magnétique séquentielle
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Boulogne, S., Roggerone, S., Deiana, G., Derex, L., Vukusic, S., Confavreux, C., and Nighoghossian, N.
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- 2014
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25. Cadre nosologique et stratégie diagnostique de la myélite aiguë transverse longitudinalement étendue
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Collongues, N., Papeix, C., Zéphir, H., Audoin, B., Cotton, F., Durand-dubief, F., Vukusic, S., Brassat, D., Laplaud, D., and Marignier, R.
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- 2014
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26. Signes et symptômes de la sclérose en plaques
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Brochet, Bruno, primary, Lebrun-Frénay, Christine, additional, de Sèze, Jérôme, additional, Zéphir, Hélène, additional, Allart, E., additional, Audoin, B., additional, Ayrignac, X., additional, Bensa, C., additional, Blanchard-Dauphin, A., additional, Brassat, D., additional, Carra-Dallière, C., additional, Clavelou, P., additional, Cohen, M., additional, Créange, A., additional, Collongues, N., additional, Debouverie, M., additional, Defer, G., additional, de Sèze, M., additional, Donzé, C., additional, Edan, G., additional, Fromont, A., additional, Gamé, X., additional, Gout, O., additional, Guillon, C., additional, Harand, C., additional, Jenny, B., additional, Labauge, P., additional, Lalive, P.-H., additional, Le Page, E., additional, Marque, P., additional, Michel, L., additional, Moisset, X., additional, Ouallet, J.-C., additional, Outteryck, O., additional, Pelé, F., additional, Pelletier, J., additional, Pittion-Vouyovitch, S., additional, Ramelli, A.-L., additional, Ruet, A., additional, Thouvenot, E., additional, Veillard, D., additional, Vignal-Clermont, C., additional, and Vukusic, S., additional
- Published
- 2017
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27. Diagnostics différentiels de la sclérose en plaques
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Brochet, Bruno, primary, Lebrun-Frénay, Christine, additional, de Sèze, Jérôme, additional, Zéphir, Hélène, additional, Allart, E., additional, Audoin, B., additional, Ayrignac, X., additional, Bensa, C., additional, Blanchard-Dauphin, A., additional, Brassat, D., additional, Carra-Dallière, C., additional, Clavelou, P., additional, Cohen, M., additional, Créange, A., additional, Collongues, N., additional, Debouverie, M., additional, Defer, G., additional, de Sèze, M., additional, Donzé, C., additional, Edan, G., additional, Fromont, A., additional, Gamé, X., additional, Gout, O., additional, Guillon, C., additional, Harand, C., additional, Jenny, B., additional, Labauge, P., additional, Lalive, P.-H., additional, Le Page, E., additional, Marque, P., additional, Michel, L., additional, Moisset, X., additional, Ouallet, J.-C., additional, Outteryck, O., additional, Pelé, F., additional, Pelletier, J., additional, Pittion-Vouyovitch, S., additional, Ramelli, A.-L., additional, Ruet, A., additional, Thouvenot, E., additional, Veillard, D., additional, Vignal-Clermont, C., additional, and Vukusic, S., additional
- Published
- 2017
- Full Text
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28. Thérapeutiques et prise en charge de la sclérose en plaques
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Brochet, Bruno, primary, Lebrun-Frénay, Christine, additional, de Sèze, Jérôme, additional, Zéphir, Hélène, additional, Allart, E., additional, Audoin, B., additional, Ayrignac, X., additional, Bensa, C., additional, Blanchard-Dauphin, A., additional, Brassat, D., additional, Carra-Dallière, C., additional, Clavelou, P., additional, Cohen, M., additional, Créange, A., additional, Collongues, N., additional, Debouverie, M., additional, Defer, G., additional, de Sèze, M., additional, Donzé, C., additional, Edan, G., additional, Fromont, A., additional, Gamé, X., additional, Gout, O., additional, Guillon, C., additional, Harand, C., additional, Jenny, B., additional, Labauge, P., additional, Lalive, P.-H., additional, Le Page, E., additional, Marque, P., additional, Michel, L., additional, Moisset, X., additional, Ouallet, J.-C., additional, Outteryck, O., additional, Pelé, F., additional, Pelletier, J., additional, Pittion-Vouyovitch, S., additional, Ramelli, A.-L., additional, Ruet, A., additional, Thouvenot, E., additional, Veillard, D., additional, Vignal-Clermont, C., additional, and Vukusic, S., additional
- Published
- 2017
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29. Diagnostic positif de la sclérose en plaques
- Author
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Brochet, Bruno, primary, Lebrun-Frénay, Christine, additional, de Sèze, Jérôme, additional, Zéphir, Hélène, additional, Allart, E., additional, Audoin, B., additional, Ayrignac, X., additional, Bensa, C., additional, Blanchard-Dauphin, A., additional, Brassat, D., additional, Carra-Dallière, C., additional, Clavelou, P., additional, Cohen, M., additional, Créange, A., additional, Collongues, N., additional, Debouverie, M., additional, Defer, G., additional, de Sèze, M., additional, Donzé, C., additional, Edan, G., additional, Fromont, A., additional, Gamé, X., additional, Gout, O., additional, Guillon, C., additional, Harand, C., additional, Jenny, B., additional, Labauge, P., additional, Lalive, P.-H., additional, Le Page, E., additional, Marque, P., additional, Michel, L., additional, Moisset, X., additional, Ouallet, J.-C., additional, Outteryck, O., additional, Pelé, F., additional, Pelletier, J., additional, Pittion-Vouyovitch, S., additional, Ramelli, A.-L., additional, Ruet, A., additional, Thouvenot, E., additional, Veillard, D., additional, Vignal-Clermont, C., additional, and Vukusic, S., additional
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- 2017
- Full Text
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30. Acute relapsing ataxic sensory neuronopathy with anti-FGFR3 autoantibodies mimicking acute myelopathy
- Author
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Theuriet, J., primary, Pegat, A., additional, Bernard, E., additional, Richard, C., additional, Camdessanche, J.-P., additional, and Vukusic, S., additional
- Published
- 2022
- Full Text
- View/download PDF
31. Deciphering multiple sclerosis disability progression in the elderly: a multicenter cohort study
- Author
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Ouallet, J-C, Rollot, F., Casey, R., Edan, G., Vukusic, S, Jonchère, Laurent, CHU Bordeaux [Bordeaux], CHU Pontchaillou [Rennes], Centre d'Investigation Clinique [Rennes] (CIC), Université de Rennes (UR)-Hôpital Pontchaillou-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre de recherche en neurosciences de Lyon - Lyon Neuroscience Research Center (CRNL), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), and Hospices Civils de Lyon (HCL)
- Subjects
[SDV] Life Sciences [q-bio] ,[SDV]Life Sciences [q-bio] - Abstract
International audience
- Published
- 2022
32. High and low efficacy therapy in secondary progressive multiple sclerosis
- Author
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Roos, I., Leray, E., Buzzard, K., Skibina, O., Lechner-Scott, J., Malpas, C. B., Butzkueven, H., Vukusic, S, Kalincik, T., University of Melbourne, Recherche en Pharmaco-épidémiologie et Recours aux Soins (REPERES), Université de Rennes (UR)-École des Hautes Études en Santé Publique [EHESP] (EHESP), École des Hautes Études en Santé Publique [EHESP] (EHESP), Centre d'Investigation Clinique [Rennes] (CIC), Université de Rennes (UR)-Hôpital Pontchaillou-Institut National de la Santé et de la Recherche Médicale (INSERM), CHU Pontchaillou [Rennes], Monash university, The Royal Melbourne Hospital, University of Newcastle [Callaghan, Australia] (UoN), Centre de recherche en neurosciences de Lyon - Lyon Neuroscience Research Center (CRNL), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), and Hospices Civils de Lyon (HCL)
- Subjects
[SDV]Life Sciences [q-bio] - Abstract
International audience; Meeting Abstract
- Published
- 2022
33. Prévenir la sclérose en plaques : un objectif réaliste ?
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Vukusic, S.
- Published
- 2012
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- View/download PDF
34. Improving the decision to switch from first to second-line therapy in MS: a dynamic scoring system
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Sabathe, C., Casey, Romain, Vukusic, S., Leray, Emmanuelle, Mathey, G., de Seze, J., Ciron, J., Wiertlewski, S., Ruet, A., Pelletier, J., Zephir, H., Michel, L., Lebrun-Frenay, C., Moisset, X., Thouvenot, Eric, Camdessanche, J. -P., Bakchine, Serge, Stankoff, B., Al Khedr, A., Cabre, P., Maillart, E., Berger, E., Heinzlef, O., Hankiewicz, K., Moreau, T., Gout, O., Bourre, B., Wahab, A., Labauge, Pierre, Montcuquet, A., Defer, G., Maurousset, A., Maubeuge, N., Dalia, D. Boulos, Ben Nasr, H., Nifle, C., Casez, O., Laplaud, D. -A., Foucher, yohann, MethodS in Patients-centered outcomes and HEalth ResEarch (SPHERE), Université de Tours (UT)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Nantes - UFR des Sciences Pharmaceutiques et Biologiques, Université de Nantes (UN)-Université de Nantes (UN), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon, Centre de recherche en neurosciences de Lyon - Lyon Neuroscience Research Center (CRNL), Université de Lyon-Université de Lyon-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Hospices Civils de Lyon (HCL), Recherche en Pharmaco-épidémiologie et Recours aux Soins (REPERES), Université de Rennes (UR)-École des Hautes Études en Santé Publique [EHESP] (EHESP), École des Hautes Études en Santé Publique [EHESP] (EHESP), Adaptation, mesure et évaluation en santé. Approches interdisciplinaires (APEMAC), Université de Lorraine (UL), Service de neurologie [CHRU Nancy], Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy), CHU Strasbourg, CIC Strasbourg (Centre d’Investigation Clinique Plurithématique (CIC - P) ), Université de Strasbourg (UNISTRA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Nouvel Hôpital Civil de Strasbourg-Hôpital de Hautepierre [Strasbourg], Centre Hospitalier Universitaire de Toulouse (CHU Toulouse), Centre hospitalier universitaire de Nantes (CHU Nantes), Centre de Recherche en Transplantation et Immunologie (U1064 Inserm - CRTI), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Nantes - UFR de Médecine et des Techniques Médicales (UFR MEDECINE), Université de Bordeaux (UB), Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale (U1215 Inserm - UB), Université de Bordeaux (UB)-Institut François Magendie-Institut National de la Santé et de la Recherche Médicale (INSERM), CIC Bordeaux, Université Bordeaux Segalen - Bordeaux 2-Institut National de la Santé et de la Recherche Médicale (INSERM), Hôpital de la Timone [CHU - APHM] (TIMONE), Lille Neurosciences & Cognition - U 1172 (LilNCog), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Centre d'Investigation Clinique [Rennes] (CIC), Université de Rennes (UR)-Hôpital Pontchaillou-Institut National de la Santé et de la Recherche Médicale (INSERM), CHU Pontchaillou [Rennes], Microenvironment, Cell Differentiation, Immunology and Cancer (MICMAC), Université de Rennes (UR)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), CHU Nice [Cimiez], Hôpital Cimiez [Nice] (CHU), CHU Clermont-Ferrand, Centre Hospitalier Universitaire de Nîmes (CHU Nîmes), Institut de Génomique Fonctionnelle (IGF), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Centre Hospitalier Universitaire de Saint-Etienne [CHU Saint-Etienne] (CHU ST-E), Centre Hospitalier Universitaire de Reims (CHU Reims), Institut du Cerveau = Paris Brain Institute (ICM), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Sorbonne Université (SU)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), CHU Amiens-Picardie, CHU de la Martinique [Fort de France], CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Service de Neurologie [CHRU Besançon], Centre Hospitalier Régional Universitaire de Besançon (CHRU Besançon), CHI Poissy-Saint-Germain, Centre Hospitalier de Saint-Denis [Ile-de-France], Centre d'épidémiologie des populations (CEP), Université de Bourgogne (UB)-Centre Régional de Lutte contre le cancer Georges-François Leclerc [Dijon] (UNICANCER/CRLCC-CGFL), UNICANCER-UNICANCER, Fondation Ophtalmologique Adolphe de Rotschild, CHU Rouen, Normandie Université (NU), CHU Henri Mondor [Créteil], CHU Montpellier, Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), CHU Limoges, CHU Caen, Normandie Université (NU)-Tumorothèque de Caen Basse-Normandie (TCBN), CHU Trousseau [Tours], Centre Hospitalier Régional Universitaire de Tours (CHRU Tours), INSERM CIC 0802 (INSERM - CHU de Poitiers), Université de Poitiers-Centre hospitalier universitaire de Poitiers (CHU Poitiers)-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre hospitalier universitaire de Poitiers (CHU Poitiers), Hémostase, Inflammation, Thrombose (HITH - U1176 Inserm - CHU Bicêtre), Institut National de la Santé et de la Recherche Médicale (INSERM)-AP-HP Hôpital Bicêtre (Le Kremlin-Bicêtre)-Université Paris-Saclay, Hôpital Sud Francilien Corbeil Essonne, Centre de Référence des Maladies Auto-Inflammatoires et des Amyloses [CH Versailles] (CeRéMAIA - Hôpital André Mignot), Centre Hospitalier de Versailles André Mignot (CHV), Laboratoire de Génétique Chromosomique [CHU de Grenoble], CHU Grenoble, Agence Nationale de la Recherche French National Research Agency (ANR) uropean Commission [ANR-10COHO-002], Fond de dotation de l'Universite de Nantes, Foundation EDMUS, ANR-10-COHO-0002,OFSEP,Observatoire Français de la Sclérose en Plaques(2010), Université de Tours-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Nantes - UFR des Sciences Pharmaceutiques et Biologiques, Centre de recherche en neurosciences de Lyon (CRNL), Université de Lyon-Université de Lyon-Université Jean Monnet [Saint-Étienne] (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-École des Hautes Études en Santé Publique [EHESP] (EHESP), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Strasbourg (UNISTRA)-Hôpital de Hautepierre [Strasbourg]-Nouvel Hôpital Civil de Strasbourg, CHU Toulouse [Toulouse], Physiopathologie de la Plasticité Neuronale (Neurocentre Magendie - U1215 Inserm), Lille Neurosciences & Cognition - U 1172 (LilNCog (ex-JPARC)), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Hôpital Pontchaillou-Institut National de la Santé et de la Recherche Médicale (INSERM), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Université de Montpellier (UM)-Université Montpellier 1 (UM1)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Montpellier 2 - Sciences et Techniques (UM2)-Centre National de la Recherche Scientifique (CNRS), Centre Hospitalier Universitaire de Saint-Etienne (CHU de Saint-Etienne), Institut du Cerveau et de la Moëlle Epinière = Brain and Spine Institute (ICM), Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), CHU Henri Mondor, Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre hospitalier universitaire de Poitiers (CHU Poitiers)-Université de Poitiers, Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), and Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)
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[SDV]Life Sciences [q-bio] ,ComputingMilieux_MISCELLANEOUS - Abstract
International audience; Meeting Abstract 035
- Published
- 2021
35. Histoire naturelle des leucodystrophies avec mutation EIF2B : étude rétrospective multicentrique de 24 cas adultes
- Author
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Carra-Dalliere, C., Horzinski, L., Ayrignac, X., Vukusic, S., Rodriguez, D., Mauguiere, F., Peter, L., Goizet, C., Bouhour, F., Denier, C., Confavreux, C., Obadia, M., Blanc, F., de Seze, J., Sedel, F., Guennoc, A.-M., Sartori, E., Laplaud, D., Antoine, J.-C., Fogli, A., Boespflug-Tanguy, O., and Labauge, P.
- Published
- 2011
- Full Text
- View/download PDF
36. Guillain-Barré syndrome following first injection of ChAdOx1 nCoV-19 vaccine: First report
- Author
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Theuriet, J., primary, Richard, C., additional, Becker, J., additional, Pegat, A., additional, Bernard, E., additional, and Vukusic, S., additional
- Published
- 2021
- Full Text
- View/download PDF
37. Clinical failure of natalizumab in multiple sclerosis: Specific causes and strategy
- Author
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Guery, D., primary, Marignier, R., additional, Durand-Dubief, F., additional, Lavie, C., additional, Pique, J., additional, Guerrier, O., additional, and Vukusic, S., additional
- Published
- 2021
- Full Text
- View/download PDF
38. Infections and multiple sclerosis: Recommendations from the French Multiple Sclerosis Society
- Author
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Papeix, C., primary, Donze, C., additional, Lebrun-Frénay, C., additional, Papeix, C., additional, Donzé, C., additional, Laplaud, D., additional, Thouvenot, E., additional, Ayrignac, X., additional, Pourcher-Martinez, V., additional, Zéphir, H., additional, de Seze, J., additional, Michel, L., additional, Bensa, C., additional, Cara-Dalliere, C., additional, Guen-noc, A.M., additional, Casez, O., additional, Maarouf, A., additional, Bourre, B., additional, Kwiatkowski, A., additional, Cohen, M., additional, Maillart, E., additional, Collongues, N., additional, Louapre, C., additional, Androdias, G., additional, Guegen, A., additional, Audoin, B., additional, Mattey, G., additional, Bernady, P., additional, Faucheux, J.M., additional, Labauge, P., additional, Meckies, C., additional, Stankoff, B., additional, Tourniaire, P., additional, Dinh, A., additional, Guennoc, A.M., additional, Durnad-Dubief, F., additional, Wiertlewski, S., additional, Derache, N., additional, Le page, E., additional, Pittion, S., additional, Vukusic, S., additional, Clavelou, P., additional, Heinzlef, O., additional, Colamarino, R., additional, Planque, E., additional, Rico, A., additional, Sheiber nogueira, C., additional, de Seze, M., additional, Ciron, J., additional, Alchaar, H., additional, Bensmail, D., additional, Biotti, D., additional, Branger, P., additional, Brochet, B., additional, Castan, B., additional, Creange, A., additional, Creisson, E., additional, DeBroucker, T., additional, Depaz, R., additional, Douay, X., additional, Dulau, C., additional, Faucher, M., additional, Fournier, M., additional, Fromont, A., additional, Gallien, P., additional, Gout, O., additional, Grimaud, J., additional, Hervé, Y., additional, Kerbrat, A., additional, Kremer, L., additional, Lanotte, L., additional, Magy, L., additional, Mania, A., additional, Maurousset, A., additional, Moisset, X., additional, Montcuquet, A., additional, Moreau, T., additional, Morel, N., additional, Patry, I., additional, Peaureaux, D., additional, Pouget, M.C., additional, Ruet, A., additional, Saint-Val, C., additional, Stahl, J.P., additional, Taithe, F., additional, Tattevin, P., additional, Vaillant, M., additional, and Vuoto, F., additional
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- 2021
- Full Text
- View/download PDF
39. Neuromyelitis optica: a positive appraisal of seronegative cases
- Author
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Bernard-Valnet, R., Liblau, R. S., Vukusic, S., and Marignier, R.
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- 2015
- Full Text
- View/download PDF
40. Histoire naturelle de la sclérose en plaques : que dire à un nouveau malade ?
- Author
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Vukusic, S. and Confavreux, C.
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- 2010
- Full Text
- View/download PDF
41. The Prevention of Post-Partum Relapses with Progestin and Estradiol in Multiple Sclerosis (POPART'MUS) trial: Rationale, objectives and state of advancement
- Author
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Vukusic, S., Ionescu, I., El-Etr, M., Schumacher, M., Baulieu, E.E., Cornu, C., and Confavreux, C.
- Published
- 2009
- Full Text
- View/download PDF
42. DMTs and Covid-19 severity in MS: a pooled analysis from Italy and France: a pooled analysis from Italy and France
- Author
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Sormani, M. (Maria Pia) P. (P), Salvetti, M. (Marco), Labauge, P. (Pierre), Schiavetti, I. (Irene), Zephir, H. (Helene), Carmisciano, L. (Luca), Bensa, C. (Caroline), De Rossi, N. (Nicola), Pelletier, J. (Jean), Cordioli, C. (Cinzia), Vukusic, S. (Sandra), Moiola, L. (Lucia), Kerschen, P. (Philippe), Radaelli, M. (Marta), Théaudin, M. (Marie), Immovilli, P. (Paolo), Casez, O. (Olivier), Capobianco, M. (Marco), Ciron, J. (Jonathan), Trojano, M. (Maria), Stankoff, B. (Bruno), Créange, A. (Alain), Tedeschi, G. (Gioacchino), Clavelou, P. (Pierre), Comi, G. (Giancarlo), Thouvenot, E. (Eric), Battaglia, M. (Mario) A. (Alberto), Moreau, T. (Thibault), Patti, F. (Francesco), De Sèze, J. (Jérôme), Louapre, C. (Celine), and Musc
- Subjects
Aucun - Abstract
We evaluated the effect of DMTs on Covid-19 severity in patients with MS, with a pooled-analysis of two large cohorts from Italy and France. The association of baseline characteristics and DMTs with Covid-19 severity was assessed by multivariate ordinal-logistic models and pooled by a fixed-effect meta-analysis. 1066 patients with MS from Italy and 721 from France were included. In the multivariate model, anti-CD20 therapies were significantly associated (OR = 2.05, 95%CI = 1.39-3.02, p
- Published
- 2021
43. Myelin-oligodendrocyte glycoprotein antibody-associated disease
- Author
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Marignier, R. Hacohen, Y. Cobo-Calvo, A. Pröbstel, A.-K. Aktas, O. Alexopoulos, H. Amato, M.-P. Asgari, N. Banwell, B. Bennett, J. Brilot, F. Capobianco, M. Chitnis, T. Ciccarelli, O. Deiva, K. De Sèze, J. Fujihara, K. Jacob, A. Kim, H.J. Kleiter, I. Lassmann, H. Leite, M.-I. Linington, C. Meinl, E. Palace, J. Paul, F. Petzold, A. Pittock, S. Reindl, M. Sato, D.K. Selmaj, K. Siva, A. Stankoff, B. Tintore, M. Traboulsee, A. Waters, P. Waubant, E. Weinshenker, B. Derfuss, T. Vukusic, S. Hemmer, B.
- Abstract
Myelin-oligodendrocyte glycoprotein antibody-associated disease (MOGAD) is a recently identified autoimmune disorder that presents in both adults and children as CNS demyelination. Although there are clinical phenotypic overlaps between MOGAD, multiple sclerosis, and aquaporin-4 antibody-associated neuromyelitis optica spectrum disorder (NMOSD) cumulative biological, clinical, and pathological evidence discriminates between these conditions. Patients should not be diagnosed with multiple sclerosis or NMOSD if they have anti-MOG antibodies in their serum. However, many questions related to the clinical characterisation of MOGAD and pathogenetic role of MOG antibodies are still unanswered. Furthermore, therapy is mainly based on standard protocols for aquaporin-4 antibody-associated NMOSD and multiple sclerosis, and more evidence is needed regarding how and when to treat patients with MOGAD. © 2021 Elsevier Ltd
- Published
- 2021
44. Rentabilité diagnostique de la biopsie de glandes salivaires accessoires dans la neurosarcoïdose : étude rétrospective à partir de 529 patients
- Author
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Fournier, N., primary, Gerfaud-Valentin, M., additional, Jamilloux, Y., additional, Streichenberger, N., additional, Vukusic, S., additional, Marignier, R., additional, Androdias, G., additional, and Sève, P., additional
- Published
- 2021
- Full Text
- View/download PDF
45. Mycophenolate mofetil in multiple sclerosis: a multicentre retrospective study on 344 patients
- Author
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Michel, L, Vukusic, S, De Seze, J, Ducray, F, Ongagna, J C, Lefrère, F, Jacq-Foucher, M, Confavreux, C, Wiertlewski, S, and Laplaud, D A
- Published
- 2014
- Full Text
- View/download PDF
46. Multiple sclerosis genomic map implicates peripheral immune cells and microglia in susceptibility
- Author
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Patsopoulos, NA, Baranzini, SE, Santaniello, A, Shoostari, P, Cotsapas, C, Wong, G, Beecham, AH, James, T, Replogle, J, Vlachos, IS, McCabe, C, Pers, TH, Brandes, A, White, C, Keenan, B, Cimpean, M, Winn, P, Panteliadis, IP, Robbins, A, Andlauer, TFM, Zarzycki, O, Dubois, B, Goris, A, Sondergaard, HB, Sellebjerg, F, Sorensen, PS, Ullum, H, Thorner, LW, Saarela, J, Cournu-Rebeix, I, Damotte, V, Fontaine, B, Guillot-Noel, L, Lathrop, M, Vukusic, S, Berthele, A, Pongratz, V, Gasperi, C, Graetz, C, Grummel, V, Hemmer, B, Hoshi, M, Knier, B, Korn, T, Lill, CM, Luessi, F, Muhlau, M, Zipp, F, Dardiotis, E, Agliardi, C, Amoroso, A, Barizzone, N, Benedetti, MD, Bernardinelli, L, Cavalla, P, Clarelli, F, Comi, G, Cusi, D, Esposito, F, Ferre, L, Galimberti, D, Guaschino, C, Leone, MA, Martinelli, V, Moiola, L, Salvetti, M, Sorosina, M, Vecchio, D, Zauli, A, Santoro, S, Mancini, N, Zuccala, M, Mescheriakova, J, van Duijn, C, Bos, SD, Celius, EG, Spurkland, A, Comabella, M, Montalban, X, Alfredsson, L, Bomfim, IL, Gomez-Cabrero, D, Hillert, J, Jagodic, M, Linden, M, Piehl, F, Jelcic, I, Martin, R, Sospedra, M, Baker, A, Ban, M, Hawkins, C, Hysi, P, Kalra, S, Karpe, F, Khadake, J, Lachance, G, Molyneux, P, Neville, M, Thorpe, J, Bradshaw, E, Caillier, SJ, Calabresi, P, Cree, BAC, Cross, A, Davis, M, de Bakker, PWI, Delgado, S, Dembele, M, Edwards, K, Fitzgerald, K, Frohlich, IY, Gourraud, PA, Haines, JL, Hakonarson, H, Kimbrough, D, Isobe, N, Konidari, I, Lathi, E, Lee, MH, Li, T, An, D, Zimmer, A, Madireddy, L, Manrique, CP, Mitrovic, M, Olah, M, Patrick, E, Pericak-Vance, MA, Piccio, L, Schaefer, C, Weiner, H, Lage, K, Scott, RJ, Lechner-Scott, J, Leal, R, Moscato, P, Booth, DR, Stewart, GJ, Vucic, S, Pame, G, BamettO, M, Mason, D, GriffithS, L, Broadley, S, Tajouri, L, Baxter, A, Slee, M, Taylor, BV, Charlesworth, J, Kilpatrick, TJ, Rubio, J, Jokubaitis, V, Wiley, J, Butzkueven, H, Leslie, S, Motyer, A, Stankovich, J, Carroll, WM, Kermode, AG, Edrin, M, Barclay, M, Peyrin-Biroulet, L, Chamaillard, M, Colombe, JF, Cottone, M, Croft, A, D'Inca, R, Halfvarson, J, Hanigan, K, Henderson, P, Hugot, JP, Karban, A, Kennedy, NA, Khan, MA, Lemann, M, Levine, A, Massey, D, Milla, M, Motoey, GW, Ng, SME, Oikonomnou, J, Peeters, H, Proctor, DD, Rahier, JF, Roberts, R, Rutgeerts, P, Seibold, F, Stronati, L, Taylor, KM, Torkvist, L, Ublick, K, Van Limbergen, J, Van Gossum, A, Vatn, MH, Zhang, H, Zhang, W, Donnelly, P, Barroso, I, Blackwe, JM, Bramon, E, Brown, MA, Casas, JP, Corvin, A, Deloukas, P, Duncanson, A, Jankowski, J, Markus, HS, Mathew, CG, Palmer, CNA, Plomin, R, Rautanen, A, Sawcer, SJ, Trembath, RC, Viswanathan, AC, Wood, NW, Spencer, CCA, Band, G, Bellenguez, C, Freeman, C, Hellenthal, G, Giannoulatou, E, Pirinen, M, Pearson, R, Strange, A, Sul, Z, Vukcevic, DA, Langford, C, Hunt, SE, Edkins, S, Gwilliam, R, Blackburn, H, Bumpstead, SJ, Dronov, S, Gillman, M, Gray, E, Hammond, N, Jayakumar, A, McCann, OT, Liddle, J, Potter, SC, Ravindrarajah, R, Ricketts, M, Waller, M, Weston, P, Widaa, S, Whittaker, P, Compston, A, Hafler, D, Harbo, HF, Hauser, SL, Stewart, G, D'Alfonso, S, Hadjigeorgiou, G, Taylor, B, Barcellos, LF, Booth, D, Hintzen, R, Kockum, I, Martinelli-Boneschi, F, McCauley, JL, Oksenberg, JR, Oturai, A, Sawcer, S, Ivinson, AJ, Olsson, T, De Jager, PL, Patsopoulos, Na, Baranzini, Se, Santaniello, A, Shoostari, P, Cotsapas, C, Wong, G, Beecham, Ah, James, T, Replogle, J, Vlachos, I, Mccabe, C, Pers, Th, Brandes, A, White, C, Keenan, B, Cimpean, M, Winn, P, Panteliadis, Ip, Robbins, A, Andlauer, Tfm, Zarzycki, O, Dubois, B, Goris, A, Sondergaard, Hb, Sellebjerg, F, Sorensen, P, Ullum, H, Thorner, Lw, Saarela, J, Cournu-Rebeix, I, Damotte, V, Fontaine, B, Guillot-Noel, L, Lathrop, M, Vukusic, S, Berthele, A, Pongratz, V, Gasperi, C, Graetz, C, Grummel, V, Hemmer, B, Hoshi, M, Knier, B, Korn, T, Lill, Cm, Luessi, F, Muhlau, M, Zipp, F, Dardiotis, E, Agliardi, C, Amoroso, A, Barizzone, N, Benedetti, Md, Bernardinelli, L, Cavalla, P, Clarelli, F, Comi, G, Cusi, D, Esposito, F, Ferre, L, Galimberti, D, Guaschino, C, Leone, Ma, Martinelli, V, Moiola, L, Salvetti, M, Sorosina, M, Vecchio, D, Zauli, A, Santoro, S, Mancini, N, Zuccala, M, Mescheriakova, J, van Duijn, C, Bos, Sd, Celius, Eg, Spurkland, A, Comabella, M, Montalban, X, Alfredsson, L, Bomfim, Il, Gomez-Cabrero, D, Hillert, J, Jagodic, M, Linden, M, Piehl, F, Jelcic, I, Martin, R, Sospedra, M, Baker, A, Ban, M, Hawkins, C, Hysi, P, Kalra, S, Karpe, F, Khadake, J, Lachance, G, Molyneux, P, Neville, M, Thorpe, J, Bradshaw, E, Caillier, Sj, Calabresi, P, Cree, Bac, Cross, A, Davis, M, de Bakker, Pwi, Delgado, S, Dembele, M, Edwards, K, Fitzgerald, K, Frohlich, Iy, Gourraud, Pa, Haines, Jl, Hakonarson, H, Kimbrough, D, Isobe, N, Konidari, I, Lathi, E, Lee, Mh, Li, T, An, D, Zimmer, A, Madireddy, L, Manrique, Cp, Mitrovic, M, Olah, M, Patrick, E, Pericak-Vance, Ma, Piccio, L, Schaefer, C, Weiner, H, Lage, K, Scott, Rj, Lechner-Scott, J, Leal, R, Moscato, P, Booth, Dr, Stewart, Gj, Vucic, S, Pame, G, Bametto, M, Mason, D, Griffiths, L, Broadley, S, Tajouri, L, Baxter, A, Slee, M, Taylor, Bv, Charlesworth, J, Kilpatrick, Tj, Rubio, J, Jokubaitis, V, Wiley, J, Butzkueven, H, Leslie, S, Motyer, A, Stankovich, J, Carroll, Wm, Kermode, Ag, Edrin, M, Barclay, M, Peyrin-Biroulet, L, Chamaillard, M, Colombe, Jf, Cottone, M, Croft, A, D'Inca, R, Halfvarson, J, Hanigan, K, Henderson, P, Hugot, Jp, Karban, A, Kennedy, Na, Khan, Ma, Lemann, M, Levine, A, Massey, D, Milla, M, Motoey, Gw, Ng, Sme, Oikonomnou, J, Peeters, H, Proctor, Dd, Rahier, Jf, Roberts, R, Rutgeerts, P, Seibold, F, Stronati, L, Taylor, Km, Torkvist, L, Ublick, K, Van Limbergen, J, Van Gossum, A, Vatn, Mh, Zhang, H, Zhang, W, Donnelly, P, Barroso, I, Blackwe, Jm, Bramon, E, Brown, Ma, Casas, Jp, Corvin, A, Deloukas, P, Duncanson, A, Jankowski, J, Markus, H, Mathew, Cg, Palmer, Cna, Plomin, R, Rautanen, A, Sawcer, Sj, Trembath, Rc, Viswanathan, Ac, Wood, Nw, Spencer, Cca, Band, G, Bellenguez, C, Freeman, C, Hellenthal, G, Giannoulatou, E, Pirinen, M, Pearson, R, Strange, A, Sul, Z, Vukcevic, Da, Langford, C, Hunt, Se, Edkins, S, Gwilliam, R, Blackburn, H, Bumpstead, Sj, Dronov, S, Gillman, M, Gray, E, Hammond, N, Jayakumar, A, Mccann, Ot, Liddle, J, Potter, Sc, Ravindrarajah, R, Ricketts, M, Waller, M, Weston, P, Widaa, S, Whittaker, P, Compston, A, Hafler, D, Harbo, Hf, Hauser, Sl, Stewart, G, D'Alfonso, S, Hadjigeorgiou, G, Taylor, B, Barcellos, Lf, Booth, D, Hintzen, R, Kockum, I, Martinelli-Boneschi, F, Mccauley, Jl, Oksenberg, Jr, Oturai, A, Sawcer, S, Ivinson, Aj, Olsson, T, De Jager, Pl, Neurology, and Immunology
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0301 basic medicine ,Multiple Sclerosis ,Quantitative Trait Loci ,Inheritance Patterns ,Cell Cycle Proteins ,Genome-wide association study ,Biology ,Major histocompatibility complex ,Polymorphism, Single Nucleotide ,Major Histocompatibility Complex ,Transcriptome ,03 medical and health sciences ,0302 clinical medicine ,Immune system ,Gene Frequency ,Autoimmune Process ,medicine ,Humans ,RNA-Seq ,X chromosome ,Genetics ,Chromosomes, Human, X ,Multidisciplinary ,Microglia ,Multiple sclerosis ,GTPase-Activating Proteins ,Chromosome Mapping ,Genomics ,medicine.disease ,3. Good health ,030104 developmental biology ,medicine.anatomical_structure ,Genetic Loci ,Case-Control Studies ,biology.protein ,Genome-Wide Association Study ,030217 neurology & neurosurgery - Abstract
Genetic roots of multiple sclerosis The genetics underlying who develops multiple sclerosis (MS) have been difficult to work out. Examining more than 47,000 cases and 68,000 controls with multiple genome-wide association studies, the International Multiple Sclerosis Genetics Consortium identified more than 200 risk loci in MS (see the Perspective by Briggs). Focusing on the best candidate genes, including a model of the major histocompatibility complex region, the authors identified statistically independent effects at the genome level. Gene expression studies detected that every major immune cell type is enriched for MS susceptibility genes and that MS risk variants are enriched in brain-resident immune cells, especially microglia. Up to 48% of the genetic contribution of MS can be explained through this analysis. Science , this issue p. eaav7188 ; see also p. 1383
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- 2019
47. Identification of Therapeutic Lag in Multiple Sclerosis
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Alroughani, Raed, IULİANO, Gerardo, Hupperts, Raymond, LechnerScott, Jeannette, Spitaleri, Daniele, Van Pesch, Vincent, Soysal, Aysun, Prevost, Julie, AgueraMorales, E, Urtaza, FJO, Türkoğlu, Recai, Sidhom, Youssef, Gouider, Riadh, Van Wijmeersch, Bart, Butzkueven, Helmut, Malpas, Charles, Vukusic, S, Kalincik, Tomas, ÖZAKBAŞ, SERKAN, Horakova, Dana, GI, Ayuso, Duquette, Pierre, ROOS, I, Leray, E, FRASCOLİ, F, Casey, Romain, Havrdova, Eva, Trojano, Maria, Madueno, SE, Patti, Francesco, Onofrj, Marco, Lugaresi, Alessandra, Prat, Alexandre, Girard, Marc, Grammond, Pierre, Sola, Patrizia, Bergamaschi, Roberto, BOZ, CAVİT, Cartechini, E, SA, MJ, TERZİ, MURAT, GrandMaison, Francois, and Granella, Franco
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- 2020
48. Aggressive multiple sclerosis (2): Treatment
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Arrambide, G., Iacobaeus, E., Amato, M. P., Derfuss, T., Vukusic, S., Hemmer, B., Brundin, L., Tintore, M., Berger, J., Boyko, A., Brinar, V., Brownlee, W., Ciccarelli, O., Coles, A., Correale, J., Cutter, G., Edan, G., Evangelou, N., Fernandez, O., Frederiksen, J., Gold, R., Hacohen, Y., Hartung, H. -P., Hellwig, K., Hillert, J., Imitola, J., Kalincik, T., Kappos, L., Khoury, S., Kim, H. J., Havrdova, E. K., Liblau, R., Lycke, J., Montalban, X., Muraro, P., Reingold, S., Schmierer, K., Sellebjerg, F., Sorensen, P. S., Solari, A., Sormani, M. P., Thompson, A., Trapp, B., Tremlett, H., Trojano, M., Tur, C., Uccelli, A., van Pesch, V., and Waubant, E.
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Aggressive ,medicine.medical_specialty ,Treatment response ,relapsing–remitting ,Disease ,Permanent disability ,multiple sclerosis ,disability ,highly active ,treatment response ,Multiple sclerosis ,03 medical and health sciences ,0302 clinical medicine ,2018 ECTRIMS Focused Workshop Group ,medicine ,Relapsing-remitting ,030212 general & internal medicine ,Intensive care medicine ,Highly active ,Therapeutic window ,Neurology & Neurosurgery ,Disability ,business.industry ,1103 Clinical Sciences ,medicine.disease ,ddc ,Natural history ,Neurology ,Relapsing remitting ,Neurology (clinical) ,business ,1109 Neurosciences ,030217 neurology & neurosurgery ,Meeting Reviews - Abstract
Altres ajuts: The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: The workshop on which the manuscript is based was supported in its entirety by the European Committee on Treatment and Research in Multiple Sclerosis (ECTRIMS). The natural history of multiple sclerosis (MS) is highly heterogeneous. A subgroup of patients has what might be termed aggressive MS. These patients may have frequent, severe relapses with incomplete recovery and are at risk of developing greater and permanent disability at the earlier stages of the disease. Their therapeutic window of opportunity may be narrow, and while it is generally considered that they will benefit from starting early with a highly efficacious treatment, a unified definition of aggressive MS does not exist and data on its treatment are largely lacking. Based on discussions at an international focused workshop sponsored by the European Committee for Treatment and Research in Multiple Sclerosis (ECTRIMS), we review our current knowledge about treatment of individuals with aggressive MS. We analyse the available evidence, identify gaps in knowledge and suggest future research needed to fill those gaps. A companion paper details the difficulties in developing a consensus about what defines aggressive MS.
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- 2020
49. Clinical Characteristics and Outcomes in Patients With Coronavirus Disease 2019 and Multiple Sclerosis
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Louapre, C. (Céline), Collongues, N. (Nicolas), Stankoff, B. (Bruno), Giannesini, C. (Claire), Papeix, C. (Caroline), Bensa, C. (Caroline), Deschamps, R. (Romain), Créange, A. (Alain), Wahab, A. (Abir), Pelletier, J. (Jean), Heinzlef, O. (Olivier), Labauge, P. (Pierre), Guilloton, L. (Laurent), Ahle, G. (Guido), Goudot, M. (Mathilde), Bigaut, K. (Kevin), Laplaud, D. (David-Axel), Vukusic, S. (Sandra), Lubetzki, C. (Catherine), and De Sèze, J. (Jérôme)
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Aucun - Abstract
Importance: Risk factors associated with the severity of coronavirus disease 2019 (COVID-19) in patients with multiple sclerosis (MS) are unknown. Disease-modifying therapies (DMTs) may modify the risk of developing a severe COVID-19 infection, beside identified risk factors such as age and comorbidities. Objective: To describe the clinical characteristics and outcomes in patients with MS and COVID-19 and identify factors associated with COVID-19 severity. Design, Setting, and Participants: The Covisep registry is a multicenter, retrospective, observational cohort study conducted in MS expert centers and general hospitals and with neurologists collaborating with MS expert centers and members of the Société Francophone de la Sclérose en Plaques. The study included patients with MS presenting with a confirmed or highly suspected diagnosis of COVID-19 between March 1, 2020, and May 21, 2020. Exposures: COVID-19 diagnosed with a polymerase chain reaction test on a nasopharyngeal swab, thoracic computed tomography, or typical symptoms. Main Outcomes and Measures: The main outcome was COVID-19 severity assessed on a 7-point ordinal scale (ranging from 1 [not hospitalized with no limitations on activities] to 7 [death]) with a cutoff at 3 (hospitalized and not requiring supplemental oxygen). We collected demographics, neurological history, Expanded Disability Severity Scale score (EDSS; ranging from 0 to 10, with cutoffs at 3 and 6), comorbidities, COVID-19 characteristics, and outcomes. Univariate and multivariate logistic regression models were used to estimate the association of collected variables with COVID-19 outcomes. Results: A total of 347 patients (mean [SD] age, 44.6 [12.8] years, 249 women; mean [SD] disease duration, 13.5 [10.0] years) were analyzed. Seventy-three patients (21.0%) had a COVID-19 severity score of 3 or more, and 12 patients (3.5%) died of COVID-19. The median EDSS was 2.0 (range, 0-9.5), and 284 patients (81.8%) were receiving DMT. There was a higher proportion of patients with a COVID-19 severity score of 3 or more among patients with no DMT relative to patients receiving DMTs (46.0% vs 15.5%; P
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- 2020
50. Aggressive multiple sclerosis (1) : Towards a definition of the phenotype
- Author
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Iacobaeus, E., Arrambide, G., Amato, M. P., Derfuss, T., Vukusic, S., Hemmer, B., Tintore, M., Brundin, L., Berger, J., Boyko, A., Brinar, V., Brownlee, W., Ciccarelli, O., Coles, A., Correale, J., Cutter, G., Edan, G., Evangelou, N., Fernandez, O., Frederiksen, J., Gold, R., Hacohen, Y., Hartung, H. -P., Hellwig, K., Hillert, J., Imitola, J., Kalincik, T., Kappos, L., Khoury, S., Kim, H. J., Havrdova, E. K., Liblau, R., Lycke, J., Montalban, X., Muraro, P., Reingold, S., Schmierer, K., Sellebjerg, F., Sorensen, P. S., Solari, A., Sormani, M. P., Thompson, A., Trapp, B., Tremlett, H., Trojano, M., Tur, C., Uccelli, A., van Pesch, V., Waubant, E., UCL - SSS/IONS/CEMO - Pôle Cellulaire et moléculaire, and UCL - (SLuc) Service de neurologie
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Disease subtype ,Aggressive ,medicine.medical_specialty ,Severe disease ,Aggressive disease ,multiple sclerosis ,Relapsing/remitting ,Multiple sclerosis ,03 medical and health sciences ,0302 clinical medicine ,disability ,highly active ,observational studies ,relapsing/remitting ,2018 ECTRIMS Focused Workshop Group ,medicine ,Intensive care medicine ,Secondary progressive ,Highly active ,Observational studies ,030304 developmental biology ,0303 health sciences ,Neurology & Neurosurgery ,Disability ,business.industry ,1103 Clinical Sciences ,medicine.disease ,Phenotype ,Additional research ,ddc ,Neurology ,Observational study ,Neurology (clinical) ,1109 Neurosciences ,business ,030217 neurology & neurosurgery ,Meeting Reviews - Abstract
Altres ajuts: The author(s) disclosed receipt of the following financial support for the research, authorship and/or publication of this article: The workshop on which the manuscript is based was supported in its entirety by the European Committee on Treatment and Research in Multiple Sclerosis (ECTRIMS). While the major phenotypes of multiple sclerosis (MS) and relapsing-remitting, primary and secondary progressive MS have been well characterized, a subgroup of patients with an active, aggressive disease course and rapid disability accumulation remains difficult to define and there is no consensus about their management and treatment. The current lack of an accepted definition and treatment guidelines for aggressive MS triggered a 2018 focused workshop of the European Committee for Treatment and Research in Multiple Sclerosis (ECTRIMS) on aggressive MS. The aim of the workshop was to discuss approaches on how to describe and define the disease phenotype and its treatments. Unfortunately, it was not possible to come to consensus on a definition because of unavailable data correlating severe disease with imaging and molecular biomarkers. However, the workshop highlighted the need for future research needed to define this disease subtype while also focusing on its treatment and management. Here, we review previous attempts to define aggressive MS and present characteristics that might, with additional research, eventually help characterize it. A companion paper summarizes data regarding treatment and management.
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- 2020
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