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Your search keyword '"Vukovic, Jana"' showing total 43 results
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43 results on '"Vukovic, Jana"'

1. A convergent evolutionary pathway attenuating cellulose production drives enhanced virulence of some bacteria

Author

Nhu, Nguyen Thi Khanh, Rahman, M. Arifur, Goh, Kelvin G. K., Kim, Seung Jae, Phan, Minh-Duy, Peters, Kate M., Alvarez-Fraga, Laura, Hancock, Steven J., Ravi, Chitra, Kidd, Timothy J., Sullivan, Matthew J., Irvine, Katharine M., Beatson, Scott A., Sweet, Matthew J., Irwin, Adam D., Vukovic, Jana, Ulett, Glen C., Hasnain, Sumaira Z., and Schembri, Mark A.

Published
2024
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14. Featured Cover.

Author

Chauquet, Solal, Willis, Emily F., Grice, Laura, Harley, Samuel B. R., Powell, Joseph E., Wray, Naomi R., Nguyen, Quan, Ruitenberg, Marc J., Shah, Sonia, and Vukovic, Jana

Subjects
T cells
Abstract

Cover legends: The cover image is based on the Research Article Exercise rejuvenates microglia and reverses T cell accumulation in the aged female mouse brain by Solal Chauquet et al., https://doi.org/10.1111/acel.14172.By Solal Chauquet; Emily F. Willis; Laura Grice; Samuel B. R. Harley; Joseph E. Powell; Naomi R. Wray; Quan Nguyen; Marc J. Ruitenberg; Sonia Shah and Jana VukovicReported by Author; Author; Author; Author; Author; Author; Author; Author; Author; Author [Extracted from the article]

Published
2024
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15. Donor bone marrow-derived macrophage MHC II drives neuroinflammation and altered behaviour during chronic GVHD in mice

Author

Adams, Rachael C, primary, Carter-Cusack, Dylan, additional, Shaikh, Samreen N, additional, Llanes, Genesis T, additional, Johnston, Rebecca L, additional, Quaife-Ryan, Gregory, additional, Boyle, Glen M, additional, Koufariotis, Lambros T, additional, Möller, Andreas, additional, Blazar, Bruce R., additional, Vukovic, Jana, additional, and MacDonald, Kelli PA, additional

Published
2021
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24. Repopulating Microglia Promote Brain Repair in an IL-6-Dependent Manner

Author

Willis, Emily F., primary, MacDonald, Kelli P.A., additional, Nguyen, Quan H., additional, Garrido, Adahir Labrador, additional, Gillespie, Ellen R., additional, Harley, Samuel B.R., additional, Bartlett, Perry F., additional, Schroder, Wayne A., additional, Yates, Abi G., additional, Anthony, Daniel C., additional, Rose-John, Stefan, additional, Ruitenberg, Marc J., additional, and Vukovic, Jana, additional

Published
2020
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27. CSF1R Inhibition Promotes Neuroinflammation and Behavioural Deficits during Graft-Versus-Host Disease in Mice

Author

Adams, Rachael C, Carter-Cusack, Dylan, Llanes, Genesis T, Hunter, Christopher R, Vinnakota, Janaki Manoja, Ruitenberg, Marc, Vukovic, Jana, Bertolino, Patrick, Chand, Kirat K., Wixey, Julie A., Nayler, Samuel P, Hill, Geoffrey R, Furlan, Scott N, Zeiser, Robert, and MacDonald, Kelli PA

Abstract

Chronic graft-versus-host disease (cGVHD) remains a significant complication of allogeneic hematopoietic stem cell transplantation. Central nervous system (CNS) involvement is becoming increasingly recognised, where brain-infiltrating donor MHC class II +bone marrow-derived macrophages (BMDM) are implicated mediators of pathology. Colony-stimulating factor 1 receptor (CSF1R)-dependent BMDM are established mediators of cutaneous and pulmonary cGVHD, and clinical trials assessing the efficacy of CSF1R antibody blockade to deplete macrophages are promising. We hypothesized that CSF1R antibody blockade may also be a useful strategy to prevent/treat CNS cGVHD.

Published
2023
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42. Promoting central nervous system regeneration: Lessons from cranial nerve I.

Author

Ruitenberg, Marc J. and Vukovic, Jana

Subjects
*NERVOUS system regeneration, *CRANIAL nerves, *OLFACTORY nerve, *TRANSPLANTATION of organs, tissues, etc., *NEUROSCIENCES
Abstract

The olfactory nerve differs from cranial nerves III-XII in that it contains a specialised type of glial cell, called 'olfactory ensheathing cell' (OEC), rather than Schwann cells. In addition, functional neurogenesis persists postnatally in the olfactory system, i.e. the primary olfactory pathway continuously rebuilds itself throughout adult life. The presence of OECs in the olfactory nerve is thought to be critical to this continuous growth process. Because of this intrinsic capacity for self-repair, the mammalian olfactory system has proved as a useful model in neuroregeneration studies. In addition, OECs have been used in transplantation studies to promote pathway regeneration elsewhere in the nervous system. Here, we have reviewed the parameters that allow for repair within the primary olfactory pathway and the role that OECs are thought to play in this process. We conclude that, in addition to intrinsic growth potential, the presence of an aligned substrate to the target structure is a fundamental prerequisite for appropriate restoration of connectivity with the olfactory bulb. Hence, strategies to promote regrowth of injured nerve pathways should incorporate usage of aligned, oriented substrates of OECs or other cellular conduits with additional intervention to boost neuronal cell body responses to injury and/or neutralisation of putative inhibitors. [ABSTRACT FROM AUTHOR]

Published
2008

43. Influence of adult Schwann cells and olfactory ensheathing glia on axon--target cell interactions in the CNS: a comparative analysis using a retinotectal co-graft model.

Author

Vukovic J, Plant GW, Ruitenberg MJ, and Harvey AR

Abstract

We used an in vivo transplant approach to examine how adult Schwann cells and olfactory ensheathing glia OEG influence the specificity of axon-target cell interactions when they are introduced into the CNS. Populations of either Schwann cells or OEG were mixed with dissociated fetal tectal cells presumptive superior colliculus and, after reaggregation, pieces were grafted onto newborn rat superior colliculus. Both glial types were prelabeled with lentiviral vectors encoding green fluorescent protein. Grafts rapidly established fiber connections with the host and retinal projections into co-grafts were assessed 656 days posttransplantation by injecting cholera toxin B into host eyes. In control rats that received pure dissociated-reaggregated tectal grafts, retinal ganglion cell RGC axons selectively innervated defined target areas, corresponding to the retinorecipient layer in normal superior colliculus. The pattern of RGC axon ingrowth into OEG containing co-grafts was similar to that in control grafts. However, in Schwann cell co-grafts there was reduced host retinal input into presumptive target areas and many RGC axons were scattered throughout the neuropil. Given that OEG in co-grafts had minimal impact on axon-target cell recognition, OEG might be an appropriate cell type for direct transplantation into injured neuropil when attempting to stimulate specific pathway reconstruction.

Published
2007
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