30 results on '"Vukšić, M."'
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2. Differential cross section measurements of the 9Be(3He,p)11B reaction for NRA applications
- Author
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Provatas, G., Fazinić, S., Soić, N., Vukman, N., Cosic, D., Krmpotić, M., Vukšić, M., Crnjac, A., Popočovski, R., Palada, L., Čolović, P., Dell’Aquila, D., Gašparić, I., Malenica, D. Jelavić, Mijatović, T., and Uroić, M.
- Published
- 2020
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3. Breit-Wigner phase is a fundamental property of a resonance
- Author
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Ceci, S., Vukšić, M., and Zauner, B.
- Subjects
High Energy Physics - Phenomenology - Abstract
In the course of devising a simple method for extraction of the S-matrix poles from the data, an additional fundamental resonance property emerged. It is a reaction invariant quantity, and since it is directly related to the Breit-Wigner parameters, we call it the Breit-Wigner phase beta. We propose that this beta is added in resonant data tables., Comment: 5 pages, 5 figures
- Published
- 2014
4. Suppression of Smad-1 mRNA expression level by Smad-2 likely control dichotomy of NF-κB and Smads mediated activation
- Author
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Slade, N., Zorić, A., Horvat, B., Vukšić, M., Kostović, I., and Poljak, L.
- Published
- 2015
- Full Text
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5. Overview of the JET preparation for deuterium-tritium operation with the ITER like-wall Recent citations
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Joffrin, E., Abduallev, S., Abhangi, M., Abreu, P., Afanasev, V., Afzal, M., Aggarwal, K.M., Ahlgren, T., Aho-Mantila, L., Aiba, N., Airila, M., Alarcon, T., Albanese, R., Alegre, D., Aleiferis, S., Alessi, E., Aleynikov, P., Alkseev, A., Allinson, M., Alper, B., Alves, E., Ambrosino, G., Ambrosino, R., Amosov, V., Andersson Sundén, E., Andrews, R., Angelone, M., Anghel, M., Angioni, C., Appel, L., Appelbee, C., Arena, P., Ariola, M., Arshad, S., Artaud, J., Arter, W., Ash, A., Ashikawa, N., Aslanyan, V., Asunta, O., Asztalos, O., Auriemma, F., Austin, Y., Avotina, L., Axton, M., Ayres, C., Baciero, A., Baião, D., Balboa, I., Balden, M., Balshaw, N., Bandaru, V.K., Banks, J., Baranov, Y.F., Barcellona, C., Barnard, T., Barnes, M., Barnsley, R., Baron Wiechec, A., Barrera Orte, L., Baruzzo, M., Basiuk, V., Bassan, M., Bastow, R., Batista, A., Batistoni, P., Baumane, L., Bauvir, B., Baylor, L., Beaumont, P.S., Beckers, M., Beckett, B., Bekris, N., Beldishevski, M., Bell, K., Belli, F., Belonohy, E., Benayas, J., Bergsåker, H., Bernardo, J., Bernert, M., Berry, M., Bertalot, L., Besiliu, C., Betar, H., Beurskens, M., Bielecki, J., Biewer, T., Bilato, R., Biletskyi, O., Bílková, P., Binda, F., Birkenmeier, G., Bizarro, J.P.S., Björkas, C., Blackburn, J., Blackman, T.R., Blanchard, P., Blatchford, P., Bobkov, V., Boboc, A., Bogar, O., Bohm, P., Bohm, T., Bolshakova, I., Bolzonella, T., Bonanomi, N., Boncagni, L., Bonfiglio, D., Bonnin, X., Boom, J., Borba, D., Borodin, D., borodkina, I., Boulbe, C., Bourdelle, C., Bowden, M., Bowman, C., Boyce, T., Boyer, H., Bradnam, S.C., Braic, V., Bravanec, R., Breizman, B., Brennan, D., Breton, S., Brett, A., Brezinsek, S., Bright, M., Brix, M., Broeckx, W., Brombin, M., Brosławski, A., Brown, B., Brunetti, D., Bruno, E., Buch, J., Buchanan, J., Buckingham, R., Buckley, M., Bucolo, M., Budny, R., Bufferand, H., Buller, S., Bunting, P., Buratti, P., Burckhart, A., Burroughes, G., Buscarino, A., Busse, A., Butcher, D., Butler, B., Bykov, I., Cahyna, P., Calabrò, G., Calacci, L., Callaghan, D., Callaghan, J., Calvo, I., Camenen, Y., Camp, P., Campling, D.C., Cannas, B., Capat, A., Carcangiu, S., Card, P., Cardinali, A., Carman, P., Carnevale, D., Carr, M., Carralero, D., Carraro, L., Carvalho, B.B., Carvalho, I., Carvalho, P., Carvalho, D.D., Casson, F.J., Castaldo, C., Catarino, N., Causa, F., Cavazzana, R., Cave-Ayland, K., Cavedon, M., Cecconello, M., Ceccuzzi, S., Cecil, E., Challis, C.D., Chandra, D., Chang, C.S., Chankin, A., Chapman, I.T., Chapman, B., Chapman, S.C., Chernyshova, M., Chiariello, A., Chitarin, G., Chmielewski, P., Chone, L., Ciraolo, G., Ciric, D., Citrin, J., Clairet, F., Clark, M., Clark, E., Clarkson, R., Clay, R., Clements, C., Coad, J.P., Coates, P., Cobalt, A., Coccorese, V., Cocilovo, V., Coelho, R., Coenen, J.W., Coffey, I., Colas, L., Colling, B., Collins, S., Conka, D., Conroy, S., Conway, N., Coombs, D., Cooper, S.R., Corradino, C., Corre, Y., Corrigan, G., Coster, D., Craciunescu, T., Cramp, S., Crapper, C., Crisanti, F., CROCI, G., Croft, D., Crombé, K., Cruz, N., Cseh, G., Cufar, A., Cullen, A., Curson, P., Curuia, M., Czarnecka, A., Czarski, T., Cziegler, I., Dabirikhah, H., Dal Molin, A., Dalgliesh, P., Dalley, S., Dankowski, J., Darrow, D., David, P., Davies, A., Davis, W., Dawson, K., Day, I., Day, C., De Bock, M., de Castro, A., De Dominici, G., De La Cal, E., De La Luna, E., De Masi, G., De Temmerman, G., De Tommasi, G., De Vries, P., Deane, J., Dejarnac, R., Del Sarto, D., Delabie, E., Demerdzhiev, V., Dempsey, A., Den Harder, N., Dendy, R.O., Denis, J., Denner, P., Devaux, S., Devynck, P., Di Maio, F., Di Siena, A., Di Troia, C., Dickinson, D., Dinca, P., Dittmar, T., Dobrashian, J., Doerk, H., Doerner, R.P., Domptail, F., Donné, T., Dorling, S.E., Douai, D., Dowson, S., Drenik, A., Dreval, M., Drewelow, P., Drews, P., Duckworth, Ph., Dumont, R., Dumortier, P., Dunai, D., Dunne, M., Ďuran, I., Durodié, F., Dutta, P., Duval, B.P., Dux, R., Dylst, K., Edappala, P.V., Edwards, A.M., Edwards, J.S., Eich, Th., Eidietis, N., Eksaeva, A., Ellis, R., Ellwood, G., Elsmore, C., Emery, S., Enachescu, M., Ericsson, G., Eriksson, J., Eriksson, F., Eriksson, L.G., Ertmer, S., Esquembri, S., Esquisabel, A.L., Esser, H.G., Ewart, G., Fable, E., Fagan, D., Faitsch, M., Falie, D., Fanni, A., Farahani, A., Fasoli, A., Faugeras, B., Fazinić, S., Felici, F., Felton, R.C., Feng, S., Fernades, A., Fernandes, H., Ferreira, J., Ferreira, D.R., Ferro, G., Fessey, J.A., Ficker, O., Field, A., Fietz, S., Figini, L., Figueiredo, A., Figueiredo, J., Fil, N., Finburg, P., Fischer, U., Fittill, L., Fitzgerald, M., Flammini, D., Flanagan, J., Flinders, K., Foley, S., Fonnesu, N., Fontdecaba, J.M., Formisano, A., Forsythe, L., Fortuna, L., Fransson, E., Frasca, M., Frassinetti, L., Freisinger, M., Fresa, R., Fridström, R., Frigione, D., Fuchs, V., Fusco, V., Futatani, S., Gál, K., Galassi, D., Gałązka, K., Galeani, S., Gallart, D., Galvão, R., Gao, Y., Garcia, J., Garcia-Carrasco, A., García-Muñoz, M., Gardener, M., Garzotti, L., Gaspar, J., Gaudio, P., Gear, D., Gebhart, T., Gee, S., Geiger, B., Gelfusa, M., George, R., Gerasimov, S., Gervasini, G., Gethins, M., Ghani, Z., Ghate, M., Gherendi, M., Ghezzi, F., Giacalone, J.C., Giacomelli, L., Giacometti, G., Gibson, K., Giegerich, T., Gil, L., Gilbert, M.R., Gin, D., Giovannozzi, E., Giroud, C., Glöggler, S., Goff, J., Gohil, P., Goloborod’ko, V., Goloborodko, V., Gomes, R., Gonçalves, B., Goniche, M., Goodyear, A., Gorini, G., Görler, T., Goulding, R., Goussarov, A., Graham, B., Graves, J.P., Greuner, H., Grierson, B., Griffiths, J., Griph, S., Grist, D., Groth, M., Grove, R., Gruca, M., Guard, D., Guérard, C., Guillemaut, C., Guirlet, R., Gulati, S., Gurl, C., Gutierrez-Milla, A., Utoh, H.H., Hackett, L., Hacquin, S., Hager, R., Hakola, A., Halitovs, M., Hall, S., Hallworth-Cook, S., Ham, C., Hamed, M., Hamilton, N., Hamlyn-Harris, C., Hammond, K., Hancu, G., Harrison, J., Harting, D., Hasenbeck, F., Hatano, Y., Hatch, D.R., Haupt, T., Hawes, J., Hawkes, N.C., Hawkins, J., Hawkins, P., Hazel, S., Heesterman, P., Heinola, K., Hellesen, C., Hellsten, T., Helou, W., Hemming, O., Hender, T.C., Henderson, S.S., Henderson, M., Henriques, R., Hepple, D., Herfindal, J., Hermon, G., Hidalgo, C., Higginson, W., Highcock, E.G., Hillesheim, J., Hillis, D., Hizanidis, K., Hjalmarsson, A., Ho, A., Hobirk, J., Hogben, C.H.A., Hogeweij, G.M.D., Hollingsworth, A., Hollis, S., Hölzl, M., Honore, J.-J., Hook, M., Hopley, D., Horáček, J., Hornung, G., Horton, A., Horton, L.D., Horvath, L., Hotchin, S.P., Howell, R., Hubbard, A., Huber, A., Huber, V., Huddleston, T.M., Hughes, M., Hughes, J., Huijsmans, G.T.A., Huynh, P., Hynes, A., Igaune, I., Iglesias, D., Imazawa, N., Imríšek, M., Incelli, M., Innocente, P., Ivanova-Stanik, I., Ivings, E., Jachmich, S., Jackson, A., Jackson, T., Jacquet, P., Jansons, J., Jaulmes, F., Jednoróg, S., Jenkins, I., Jepu, I., Johnson, T., Johnson, R., Johnston, J., Joita, L., Joly, J., Jonasson, E., Jones, T., Jones, C., Jones, L., Jones, G., Jones, N., Juvonen, M., Hoshino, K.K., Kallenbach, A., Kalsey, M., Kaltiaisenaho, T., Kamiya, K., Kaniewski, J., Kantor, A., Kappatou, A., Karhunen, J., Karkinsky, D., Kaufman, M., Kaveney, G., Kazakov, Y., Kazantzidis, V., Keeling, D.L., Keenan, F.P., Kempenaars, M., Kent, O., Kent, J., Keogh, K., Khilkevich, E., Kim, H.-T., King, R., King, D., Kinna, D.J., Kiptily, V., Kirk, A., Kirov, K., Kirschner, A., Kizane, G., Klas, M., Klepper, C., Klix, A., Knight, M., Knight, P., Knipe, S., Knott, S., Kobuchi, T., Köchl, F., Kocsis, G., Kodeli, I., Koechl, F., Kogut, D., Koivuranta, S., Kolesnichenko, Y., Kollo, Z., Kominis, Y., Köppen, M., Korolczuk, S., Kos, B., Koslowski, H.R., Kotschenreuther, M., Koubiti, M., Kovaldins, R., Kovanda, O., Kowalska-Strzęciwilk, E., Krasilnikov, A., Krasilnikov, V., Krawczyk, N., Kresina, M., Krieger, K., Krivska, A., Kruezi, U., Książek, I., Kukushkin, A., Kundu, A., Kurki-Suonio, T., Kwak, S., Kwon, O.J., Laguardia, L., Lahtinen, A., Laing, A., Lalousis, P., Lam, N., Lamb, C., Lambertz, H.T., Lang, P.T., Lanthaler, S., Lascas Neto, E., Łaszyńska, E., Lawless, R., Lawson, K.D., Lazaros, A., Lazzaro, E., Leach, R., Learoyd, G., Leerink, S., Lefebvre, X., Leggate, H.J., Lehmann, J., Lehnen, M., Leichauer, P., Leichtle, D., Leipold, F., Lengar, I., Lennholm, M., Lepiavko, B., Leppänen, J., Lerche, E., Lescinskis, A., Lescinskis, B., Lesnoj, S., Leyland, M., Leysen, W., Li, Y., Li, L., Liang, Y., Likonen, J., Linke, J., Linsmeier, Ch., Lipschultz, B., Litaudon, X., Liu, G., Lloyd, B., Lo Schiavo, V.P., Loarer, T., Loarte, A., Lomanowski, B., Lomas, P.J., Lönnroth, J., López, J.M., Lorenzini, R., Losada, U., Loughlin, M., Lowry, C., Luce, T., Lucock, R., Lukin, A., Luna, C., Lungaroni, M., Lungu, C.P., Lungu, M., Lunniss, A., Lunt, T., Lupelli, I., Lutsenko, V., Lyssoivan, A., Macheta, P., Macusova, E., Magesh, B., Maggi, C., Maggiora, R., Mahesan, S., Maier, H., Mailloux, J., Maingi, R., Makwana, R., Malaquias, A., Malinowski, K., Malizia, A., Manas, P., Manduchi, G., Manso, M.E., Mantica, P., Mantsinen, M., Manzanares, A., Maquet, Ph., Marandet, Y., Marcenko, N., Marchetto, C., Marchuk, O., Marconato, N., Mariani, A., Marin, M., Marinelli, M., Marinucci, M., Markovič, T., Marocco, D., Marot, L., Marsh, J., Martin, A., Martin De Aguilera, A., Martín-Solís, J.R., Martone, R., Martynova, Y., Maruyama, S., Maslov, M., Matejcik, S., Mattei, M., Matthews, G.F., Matveev, D., Matveeva, E., Mauriya, A., Maviglia, F., May-Smith, T., Mayer, M., Mayoral, M.L., Mazon, D., Mazzotta, C., Mcadams, R., McCarthy, P.J., McClements, K.G., McCormack, O., McCullen, P.A., Mcdonald, D., McHardy, M., McKean, R., McKehon, J., McNamee, L., Meadowcroft, C., Meakins, A., Medley, S., Meigh, S., Meigs, A.G., Meisl, G., Meiter, S., Meitner, S., Meneses, L., Menmuir, S., Mergia, K., Merle, A., Merriman, P., Mertens, Ph., Meshchaninov, S., Messiaen, A., Meyer, 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Poulipoulis, G., Powell, T., Prajapati, V., Prakash, R., Predebon, I., Prestopino, G., Price, D., Price, M., Price, R., Primetzhofer, D., Prior, P., Pucella, G., Puglia, P., Puiatti, M.E., Purahoo, K., Pusztai, I., Pütterich, Th., Rachlew, E., Rack, M., Ragona, R., Rainford, M., Raj, P., Rakha, A., Ramogida, G., Ranjan, S., Rapson, C.J., Rasmussen, D., Rasmussen, J.J., Rathod, K., Rattá, G., Ratynskaia, S., Ravera, G., Rebai, M., Reed, A., Réfy, D., Regaña, J., Reich, M., Reid, N., Reimold, F., Reinhart, M., Reinke, M., Reiser, D., Rendell, D., Reux, C., Reyes Cortes, S.D.A., Reynolds, S., Ricci, D., Richiusa, M., Rigamonti, D., Rimini, F.G., Risner, J., Riva, M., Rivero-Rodriguez, J., Roach, C., Robins, R., Robinson, S., Robson, D., Rodionov, R., Rodrigues, P., Rodriguez, J., Rohde, V., Romanelli, Marco, Romanelli, F., Romanelli, S., Romazanov, J., Rowe, S., Rubel, M., Rubinacci, G., Rubino, G., Ruchko, L., Ruset, C., Rzadkiewicz, J., Saarelma, S., Sabot, R., Sáez, X., Safi, E., 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Withycombe, A., Witts, D., Wolfrum, E., Wood, R., Woodley, R., Woodley, C., Wray, S., Wright, J.C., Wright, P., Wukitch, S., Wynn, A., Xiang, L., Xu, T., Xue, Y., Yadikin, D., Yakovenko, Y., Yanling, W., Yavorskij, V., Young, I., Young, R., Young, D., Zacks, J., Zagorski, R., Zaitsev, F.S., Zakharov, L., Zanino, R., Zarins, A., Zarins, R., Zarzoso Fernandez, D., Zastrow, K.D., Zerbini, M., Zhang, W., Zhou, Y., Zilli, E., Zocco, A., Zoita, V., Zoletnik, S., Zwingmann, W., Zychor, I., CEA Cadarache, Commissariat à l'énergie atomique et aux énergies alternatives (CEA), VTT Technical Research Centre of Finland (VTT), Naka Fusion Institute, National Institutes for Quantum and Radiological Science and Technology (QST), Association EURATOM-TEKES, Association EURATOM-TEKES, Helsinki University of Technology, Finland, Institut de Recherche sur la Fusion par confinement Magnétique (IRFM), STMicroelectronics, EURATOM/CCFE Fusion Association, Culham Science Centre [Abingdon], Assoc. Euratom-ENEA-CREATE, Università degli studi di Napoli Federico II, Universita degli studi di Napoli 'Parthenope' [Napoli], Queen's University [Kingston], Max-Planck-Institut für Plasmaphysik [Garching] (IPP), Università degli studi di Catania [Catania], National Institute for Fusion Science (NIFS), Massachusetts Institute of Technology (MIT), Culham Centre for Fusion Energy (CCFE), North Carolina State University [Raleigh] (NC State), University of North Carolina System (UNC), Conseil National de Recherches Canada (CNRC), ITER Organization, Consorzio RFX, Associazione Euratom/ENEA sulla Fusione (RFX), Italian National Agency for New Technologies, Energy and Sustainable Economic Development (ENEA), EUROfus Program Management Unit PMU, European Fusion Development Agreement [Garching bei München] ( EFDA-CSU), ITER [St. Paul-lez-Durance], ITER, H. Niewodniczanski Institute of Nuclear Physics, Polska Akademia Nauk (PAN), Maladies chroniques, santé perçue, et processus d'adaptation (APEMAC), Université de Lorraine (UL), Cités, Territoires, Environnement et Sociétés (CITERES), Université de Tours-Centre National de la Recherche Scientifique (CNRS), Euratom/UKAEA Fusion Assoc., Magnetic Sensor laboratory [Lviv] (MSL), National Polytechnic University of Lviv (LPNU), Bar-Ilan University [Israël], The National Research Nuclear University MEPhI (Moscow Engineering Physics Institute) [Moscow, Russia], Institute of Energy and Climate Research - Plasma Physics (IEK-4), Forschungszentrum Jülich GmbH, Institute for Problems of Material Science, National Academy of Sciences of Ukraine (NASU), Institute of Plasma Physics [Praha], Czech Academy of Sciences [Prague] (ASCR), Istituto di Fisica del Plasma, EURATOM-ENEA-CNR Association, Consiglio Nazionale delle Ricerche [Roma] (CNR), Physique des interactions ioniques et moléculaires (PIIM), Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS), Dipartimento di Informatica Sistemi e Produzione, University of Rome Tor Vergata (DISP), Università degli Studi di Roma Tor Vergata [Roma], Département Méthodes et Modèles Mathématiques pour l'Industrie (3MI-ENSMSE), École des Mines de Saint-Étienne (Mines Saint-Étienne MSE), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT)-Centre G2I, Instituto de Plasmas e Fusão Nuclear [Lisboa] (IPFN), Instituto Superior Técnico, Universidade Técnica de Lisboa (IST), Institute for Plasma Research, Bhat, Gandhinagar India, Jet Propulsion Laboratory (JPL), NASA-California Institute of Technology (CALTECH), Institute of Plasma Physics and Laser Microfusion [Warsaw] (IPPLM), Dutch Institute for Fundamental Energy Research [Eindhoven] (DIFFER), Astrophysics Research Centre [Belfast] (ARC), Queen's University [Belfast] (QUB), Associazone EURATOM ENEA sulla Fusione, EURATOM, Laboratoire de physique des plasmas de l'ERM, Laboratorium voor plasmafysica van de KMS (LPP ERM KMS), Ecole Royale Militaire / Koninklijke Militaire School (ERM KMS), Centro de Investigaciones Energéticas Medioambientales y Tecnológicas [Madrid] (CIEMAT), Institut für Physik, University of Basel (Unibas), Institute of Plasma Physics, Association Euratom/IPP.CR (IPP PRAGUE), Institut Jean Lamour (IJL), Université de Lorraine (UL)-Centre National de la Recherche Scientifique (CNRS), Dutch Institute for Fundamental Energy Research [Nieuwegein] (DIFFER), Dipartimento di Energia [Milano] (DENG), Politecnico di Milano [Milan] (POLIMI), NIPNE -Bucharest-Magurele (NIPNE), NIPNE, Laboratory for Plasma Physics (LPP), Ecole Polytechnique Fédérale de Lausanne (EPFL), Département d'Astrophysique, de physique des Particules, de physique Nucléaire et de l'Instrumentation Associée (DAPNIA), Centre de Recherches en Physique des Plasmas (CRPP), Laboratoire Jean Alexandre Dieudonné (JAD), Université Nice Sophia Antipolis (... - 2019) (UNS), Université Côte d'Azur (UCA)-Université Côte d'Azur (UCA)-Centre National de la Recherche Scientifique (CNRS), Southern University of Science and Technology [Shenzhen] (SUSTech), Institut de Planétologie et d'Astrophysique de Grenoble (IPAG), Centre National d'Études Spatiales [Toulouse] (CNES)-Université Grenoble Alpes (UGA)-Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire des Sciences de l'Univers de Grenoble (OSUG), Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP)-Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA)-Université Joseph Fourier - Grenoble 1 (UJF)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP)-Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA)-Université Joseph Fourier - Grenoble 1 (UJF)-Centre National de la Recherche Scientifique (CNRS), University of Évora [Portugal], Laboratoire de Spectrochimie Infrarouge et Raman - UMR 8516 (LASIR), Centre National de la Recherche Scientifique (CNRS)-Université de Lille, Dipartimento di Ingegneria Elettrica Elettronica e dei Sistemi, Department of Physics [Stockholm], Stockholm University, Laboratoire de Mécanique, Modélisation et Procédés Propres (M2P2), Aix Marseille Université (AMU)-École Centrale de Marseille (ECM)-Centre National de la Recherche Scientifique (CNRS), Sichuan University, Istituto Nazionale di Geofisica e di Oceanografia Sperimentale (OGS), Operations Department (ESAC), European Space Astronomy Centre (ESAC), European Space Agency (ESA)-European Space Agency (ESA), A.F. 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Institut Energie & Klimaforsch, Oak Ridge National Laboratory [Oak Ridge] (ORNL), UT-Battelle, LLC, Karlsruhe Institute of Technology (KIT), Institut fur Energie und Klimaforschung - Plasmaphysik (IEK-4), CEA-Direction de l'Energie Nucléaire (CEA-DEN), Gulliver, ESPCI ParisTech-Centre National de la Recherche Scientifique (CNRS), National Center for Atmospheric Research [Boulder] (NCAR), Aalto University, Institut Européen des membranes (IEM), Université de Montpellier (UM)-Université Montpellier 2 - Sciences et Techniques (UM2)-Ecole Nationale Supérieure de Chimie de Montpellier (ENSCM)-Centre National de la Recherche Scientifique (CNRS), System Design Department, IHP Microelctronics, LPSM UMR 8001 - Laboratoire de Probabilités, Statistique et Modélisation, York Plasma Institute (YPI), University of York [York, UK], Centre for Plasma Physics, Association EURATOM, Guizhou Institute of Technology, Laboratoire d'Énergétique Moléculaire et Macroscopique, Combustion (EM2C), CentraleSupélec-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), Aalto University School of Science and Technology, PELIN Laboratory, 27A, Gzhatskaya, Saint-Petersburg, Space Research Institute of the Russian Academy of Sciences (IKI), Faculty of Mathematics and Physics [Praha/Prague], Charles University [Prague], Euratom/UKEAE Fusion Association (JET), UKEA, INAF-IASF/Rome, Istituto Nazionale di Astrofisica (INAF), Ricerca Formazione Innovazione (Consorzio RFX), Consiglio Nazionale delle Ricerche (CNR), Barcelona Supercomputing Center - 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Joint Research Centre [Karlsruhe] (JRC), National Center for Scientific Research 'Demokritos' (NCSR), Laboratorio Nacional de Fusión [Madrid], Asociación Euratom-CIEMAT, Michigan State University [East Lansing], Michigan State University System, Unit of Lymphoid Malignancies, San Raffaele Scientific Institute, Università degli studi di Cassino e del Lazio Meridionale (UNICAS), Health and Safety Laboratory, Centre de Nanosciences et de Nanotechnologies [Orsay] (C2N), Université Paris-Sud - Paris 11 (UP11)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), California Institute of Technology (CALTECH)-NASA, Université de Lille, Sciences et Technologies-Centre National de la Recherche Scientifique (CNRS), Science et Ingénierie des Matériaux et Procédés (SIMaP), Université Joseph Fourier - Grenoble 1 (UJF)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP)-Institut National Polytechnique de Grenoble (INPG)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA), Université Paris-Sud - Paris 11 (UP11)-Centre National de la Recherche Scientifique (CNRS)-Université Paris-Saclay, COMUE Université Côte d'Azur (2015 - 2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015 - 2019) (COMUE UCA)-Centre National de la Recherche Scientifique (CNRS), Observatoire des Sciences de l'Univers de Grenoble (OSUG), Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP)-Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA)-Université Joseph Fourier - Grenoble 1 (UJF)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP)-Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA)-Université Joseph Fourier - Grenoble 1 (UJF)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS), Université de Lille-Centre National de la Recherche Scientifique (CNRS), CEA-Direction des Energies (ex-Direction de l'Energie Nucléaire) (CEA-DES (ex-DEN)), Laboratoire de Probabilités, Statistiques et Modélisations (LPSM (UMR_8001)), Université Paris Diderot - Paris 7 (UPD7)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-CEA-Direction des Energies (ex-Direction de l'Energie Nucléaire) (CEA-DES (ex-DEN)), Matériaux et nanosciences d'Alsace, Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Université de Strasbourg (UNISTRA)-Réseau nanophotonique et optique, Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA), Istituto Nazionale di Fisica Nucleare (INFN), Université Paris Diderot - Paris 7 (UPD7)-Groupe Hospitalier Saint Louis - Lariboisière - Fernand Widal [Paris], Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-Assistance publique - Hôpitaux de Paris (AP-HP) (APHP), CentraleSupélec-Centre National de la Recherche Scientifique (CNRS)-Université Paris-Saclay, and Centre National de la Recherche Scientifique (CNRS)-Aix Marseille Université (AMU)-Assistance Publique - Hôpitaux de Marseille (APHM)
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[PHYS.PHYS.PHYS-PLASM-PH]Physics [physics]/Physics [physics]/Plasma Physics [physics.plasm-ph] ,ComputingMilieux_MISCELLANEOUS - Abstract
International audience
- Published
- 2019
- Full Text
- View/download PDF
6. Underdevelopment of the Human Hippocampus in Callosal Agenesis: An In Vivo Fetal MRI Study
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Knezović, V., primary, Kasprian, G., additional, Štajduhar, A., additional, Schwartz, E., additional, Weber, M., additional, Gruber, G.M., additional, Brugger, P.C., additional, Prayer, D., additional, and Vukšić, M., additional
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- 2019
- Full Text
- View/download PDF
7. OC06.03: Reduced hippocampal volume in human fetal brains with agenesis of the corpus callosum revealed by magnetic resonance imaging
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Knezović, V., primary, Štajduhar, A., additional, Schwartz, E., additional, Prayer, D., additional, Vukšić, M., additional, and Kasprian, G., additional
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- 2017
- Full Text
- View/download PDF
8. Proizvodnja bioplina iz leguminoza
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Jovičić, Daria, Kralik, Davor, Ivanović, M, Vukšić, M, Mirjanić, Jelena, and Dundović, J.
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bioplin ,biomasa ,svinjska gnojovka ,lucerna - Abstract
Biomasa u proizvodnji energije je interesantna jer je moguća kontinuirana opskrba bioplinskih postrojenja sa ujednačenom kvalitetom sirovine tijekom cijele godine. U današnjem svijetu zahtjevi za hranom i energijom neprestano se povećavaju. Zbog povećane potražnje za hranom posebno životinjskoga podrijetla farme povećavaju svoju proizvodnju i na taj način povećavaju količinu otpada. Konverzijom otpada s farmi i biomase u bioplin tj. energiju gospodarstva mogu ostvariti dodatnu ekonomsku dobit. Radi utvrđivanja energetskog potencijala lucerne korištena je svježa svinjska gnojovka i svježa lucerna (Medicago sativa). Kontrolna skupina bila je svježa svinjska gnojovka (K) a eksperimentalna grupa je bila svježa svinjska gnojovka uz dodatak 10% (m/m) svježe lucerne (KS). Svježa gnojovka kao kontrolna skupina sadržavala je 9, 05% suhe tvari dok je kesperimentalna sadržavala 9, 73% suhe tvari. Određen je sadržaj krute tvari, postotak vlage, sadržaj pepela i organske tvari. Elektrokemijskim mjerenjem utvrđen je pH. Istraživanje je postavljeno u diskontinuiranim bioreaktorima (zapremine 1000 ml) pri mezofilnim uvjetima (35°C) u tri ponavljanja. Vrijeme zadržavanja bilo je 61 dana.
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- 2010
9. Overview of the JET preparation for deuterium–tritium operation with the ITER like-wall
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Joffrin, E., Abduallev, S., Abhangi, M., Abreu, P., Afanasev, V., Afzal, M., Aggarwal, K.M., Ahlgren, T., Aho-Mantila, L., Aiba, N., Airila, M., Alarcon, T., Albanese, R., Alegre, D., Aleiferis, S., Alessi, E., Aleynikov, P., Alkseev, A., Allinson, M., Alper, B., Alves, E., Ambrosino, G., Ambrosino, R., Amosov, V., Andersson Sundén, E., Andrews, R., Angelone, M., Anghel, M., Angioni, C., Appel, L., Appelbee, C., Arena, P., Ariola, M., Arshad, S., Artaud, J., Arter, W., Ash, A., Ashikawa, N., Aslanyan, V., Asunta, O., Asztalos, O., Auriemma, F., Austin, Y., Avotina, L., Axton, M., Ayres, C., Baciero, A., Baião, D., Balboa, I., Balden, M., Balshaw, N., Bandaru, V.K., Banks, J., Baranov, Y.F., Barcellona, C., Barnard, T., Barnes, M., Barnsley, R., Baron Wiechec, A., Barrera Orte, L., Baruzzo, M., Basiuk, V., Bassan, M., Bastow, R., Batista, A., Batistoni, P., Baumane, L., Bauvir, B., Baylor, L., Beaumont, P.S., Beckers, M., Beckett, B., Bekris, N., Beldishevski, M., Bell, K., Belli, F., Belonohy, É., Benayas, J., Bergsåker, H., Bernardo, J., Bernert, M., Berry, M., Bertalot, L., Besiliu, C., Betar, H., Beurskens, M., Bielecki, J., Biewer, T., Bilato, R., Biletskyi, O., Bílková, P., Binda, F., Birkenmeier, G., Bizarro, J.P.S., Björkas, C., Blackburn, J., Blackman, T.R., Blanchard, P., Blatchford, P., Bobkov, V., Boboc, A., Bogar, O., Bohm, P., Bohm, T., Bolshakova, I., Bolzonella, T., Bonanomi, N., Boncagni, L., Bonfiglio, D., Bonnin, X., Boom, J., Borba, D., Borodin, D., Borodkina, I., Boulbe, C., Bourdelle, C., Bowden, M., Bowman, C., Boyce, T., Boyer, H., Bradnam, S.C., Braic, V., Bravanec, R., Breizman, B., Brennan, D., Breton, S., Brett, A., Brezinsek, S., Bright, M., Brix, M., Broeckx, W., Brombin, M., Brosławski, A., Brown, B., Brunetti, D., Bruno, E., Buch, J., Buchanan, J., Buckingham, R., Buckley, M., Bucolo, M., Budny, R., Bufferand, H., Buller, S., Bunting, P., Buratti, P., Burckhart, A., Burroughes, G., Buscarino, A., Busse, A., Butcher, D., Butler, B., 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A., Kundu, A., Kurki-Suonio, T., Kwak, S., Kwon, O.J., Laguardia, L., Lahtinen, A., Laing, A., Lalousis, P., Lam, N., Lamb, C., Lambertz, H.T., Lang, P.T., Lanthaler, S., Lascas Neto, E., Łaszyńska, E., Lawless, R., Lawson, K.D., Lazaros, A., Lazzaro, E., Leach, R., Learoyd, G., Leerink, S., Lefebvre, X., Leggate, H.J., Lehmann, J., Lehnen, M., Leichauer, P., Leichtle, D., Leipold, F., Lengar, I., Lennholm, M., Lepiavko, B., Leppänen, J., Lerche, E., Lescinskis, A., Lescinskis, B., Lesnoj, S., Leyland, M., Leysen, W., Li, Y., Li, L., Liang, Y., Likonen, J., Linke, J., Linsmeier, Ch., Lipschultz, B., Litaudon, X., Liu, G., Lloyd, B., Lo Schiavo, V.P., Loarer, T., Loarte, A., Lomanowski, B., Lomas, P.J., Lönnroth, J., López, J.M., Lorenzini, R., Losada, U., Loughlin, M., Lowry, C., Luce, T., Lucock, R., Lukin, A., Luna, C., Lungaroni, M., Lungu, C.P., Lungu, M., Lunniss, A., Lunt, T., Lupelli, I., Lutsenko, V., Lyssoivan, A., Macheta, P., Macusova, E., Magesh, B., Maggi, C., Maggiora, R., Mahesan, S., Maier, H., Mailloux, J., Maingi, R., Makwana, R., Malaquias, A., Malinowski, K., Malizia, A., Manas, P., Manduchi, G., Manso, M.E., Mantica, P., Mantsinen, M., Manzanares, A., Maquet, Ph., Marandet, Y., Marcenko, N., Marchetto, C., Marchuk, O., Marconato, N., Mariani, A., Marin, M., Marinelli, M., Marinucci, M., Markovič, T., Marocco, D., Marot, L., Marsh, J., Martin, A., Martín De Aguilera, A., Martín-Solís, J.R., Martone, R., Martynova, Y., Maruyama, S., Maslov, M., Matejcik, S., Mattei, M., Matthews, G.F., Matveev, D., Matveeva, E., Mauriya, A., Maviglia, F., May-Smith, T., Mayer, M., Mayoral, M.L., Mazon, D., Mazzotta, C., McAdams, R., McCarthy, P.J., McClements, K.G., McCormack, O., McCullen, P.A., McDonald, D., McHardy, M., McKean, R., McKehon, J., McNamee, L., Meadowcroft, C., Meakins, A., Medley, S., Meigh, S., Meigs, A.G., Meisl, G., Meiter, S., Meitner, S., Meneses, L., Menmuir, S., Mergia, K., Merle, A., Merriman, P., Mertens, Ph., Meshchaninov, S., Messiaen, A., Meyer, H., Michling, R., Milanesio, D., Militello, F., Militello-Asp, E., Milocco, A., Miloshevsky, G., Mink, F., Minucci, S., Miron, I., Mistry, S., Miyoshi, Y., Mlynář, J., Moiseenko, V., Monaghan, P., Monakhov, I., Moon, S., Mooney, R., Moradi, S., Morales, J., Moran, J., Mordijck, S., Moreira, L., Moro, F., Morris, J., Moser, L., Mosher, S., Moulton, D., Mrowetz, T., Muir, A., Muraglia, M., Murari, A., Muraro, A., Murphy, S., Muscat, P., Muthusonai, N., Myers, C., Asakura, N.N., N’Konga, B., Nabais, F., Naish, R., Naish, J., Nakano, T., Napoli, F., Nardon, E., Naulin, V., Nave, M.F.F., Nedzelskiy, I., Nemtsev, G., Nesenevich, V., Nespoli, F., Neto, A., Neu, R., Neverov, V.S., Newman, M., Ng, S., Nicassio, M., Nielsen, A.H., Nina, D., Nishijima, D., Noble, C., Nobs, C.R., Nocente, M., Nodwell, D., Nordlund, K., Nordman, H., Normanton, R., Noterdaeme, J.M., Nowak, S., Nunes, I., O’Gorman, T., O’Mullane, M., Oberkofler, M., Oberparleiter, M., Odupitan, T., Ogawa, M.T., Okabayashi, M., Oliver, H., Olney, R., Omoregie, L., Ongena, J., Orsitto, F., Orszagh, J., Osborne, T., Otin, R., Owen, A., Owen, T., Paccagnella, R., Packer, L.W., Pajuste, E., Pamela, S., Panja, S., Papp, P., Papp, G., Parail, V., Pardanaud, C., Parra Diaz, F., Parsloe, A., Parsons, N., Parsons, M., Pasqualotto, R., Passeri, M., Patel, A., Pathak, S., Patten, H., Pau, A., Pautasso, G., Pavlichenko, R., Pavone, A., Pawelec, E., Paz Soldan, C., Peackoc, A., Pehkonen, S.-P., Peluso, E., Penot, C., Penzo, J., Pepperell, K., Pereira, R., Perelli Cippo, E., Perez Von Thun, C., Pericoli, V., Peruzzo, S., Peterka, M., Petersson, P., Petravich, G., Petre, A., Petržilka, V., Philipps, V., Pigatto, L., Pillon, M., Pinches, S., Pintsuk, G., Piovesan, P., Pires De Sa, W., Pires Dos Reis, A., Piron, L., Piron, C., Pironti, A., Pisano, F., Pitts, R., Plyusnin, V., Poli, F.M., Pomaro, N., Pompilian, O.G., Pool, P., Popovichev, S., Poradziński, M., Porfiri, M.T., Porosnicu, C., Porton, M., Possnert, G., Potzel, S., Poulipoulis, G., Powell, T., Prajapati, V., Prakash, R., Predebon, I., Prestopino, G., Price, D., Price, M., Price, R., Primetzhofer, D., Prior, P., Pucella, G., Puglia, P., Puiatti, M.E., Purahoo, K., Pusztai, I., Pütterich, Th., Rachlew, E., Rack, M., Ragona, R., Rainford, M., Raj, P., Rakha, A., Ramogida, G., Ranjan, S., Rapson, C.J., Rasmussen, D., Rasmussen, J.J., Rathod, K., Rattá, G., Ratynskaia, S., Ravera, G., Rebai, M., Reed, A., Réfy, D., Regaña, J., Reich, M., Reid, N., Reimold, F., Reinhart, M., Reinke, M., Reiser, D., Rendell, D., Reux, C., Reyes Cortes, S.D.A., Reynolds, S., Ricci, D., Richiusa, M., Rigamonti, D., Rimini, F.G., Risner, J., Riva, M., Rivero-Rodriguez, J., Roach, C., Robins, R., Robinson, S., Robson, D., Rodionov, R., Rodrigues, P., Rodriguez, J., Rohde, V., Romanelli, M., Romanelli, F., Romanelli, S., Romazanov, J., Rowe, S., Rubel, M., Rubinacci, G., Rubino, G., Ruchko, L., Ruset, C., Rzadkiewicz, J., Saarelma, S., Sabot, R., Sáez, X., 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13. Climate action ,JET ,tritium ,fusion power ,isotope ,7. Clean energy - Abstract
For the past several years, the JET scientific programme (Pamela et al 2007 Fusion Eng. Des. 82 590) has been engaged in a multi-campaign effort, including experiments in D, H and T, leading up to 2020 and the first experiments with 50%/50% D–T mixtures since 1997 and the first ever D–T plasmas with the ITER mix of plasma-facing component materials. For this purpose, a concerted physics and technology programme was launched with a view to prepare the D–T campaign (DTE2). This paper addresses the key elements developed by the JET programme directly contributing to the D–T preparation. This intense preparation includes the review of the physics basis for the D–T operational scenarios, including the fusion power predictions through first principle and integrated modelling, and the impact of isotopes in the operation and physics of D–T plasmas (thermal and particle transport, high confinement mode (H-mode) access, Be and W erosion, fuel recovery, etc). This effort also requires improving several aspects of plasma operation for DTE2, such as real time control schemes, heat load control, disruption avoidance and a mitigation system (including the installation of a new shattered pellet injector), novel ion cyclotron resonance heating schemes (such as the threeions scheme), new diagnostics (neutron camera and spectrometer, active Alfvèn eigenmode antennas, neutral gauges, radiation hard imaging systems…) and the calibration of the JET neutron diagnostics at 14 MeV for accurate fusion power measurement. The active preparation of JET for the 2020 D–T campaign provides an incomparable source of information and a basis for the future D–T operation of ITER, and it is also foreseen that a large number of key physics issues will be addressed in support of burning plasmas.
10. Recent findings in etiopathogenesis of Alzheimer's disease: does Alzheimer's disease begin in the dorsal raphe nucleus?
- Author
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Šimić, Goran, Kostović, I, Jernej, B, Judaš, M, and Vukšić, M
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aging ,Alzheimer's disease ,behavioral and psychological symptoms ,cerebrospinal fluid ,dorsal raphe nucleus ,early diagnosis ,fetal brain development ,neurofibrillary degeneration ,serotonin ,tau protein - Abstract
Although substantial evidence indicates that the progression of pathological changes of the neuronal cytoskeleton is crucial in determining the severity of dementia in Alzheimer’ s disease (AD), the exact causes and evolution of these changes, the initial site at which they begin, and the neuronal susceptibility levels for their development are poorly understood. The current clinical criteria for diagnosis of AD are focused mostly on cognitive deficits produced by dysfunction of hippocampal and high-order neocortical areas, whereas noncognitive, behavioural and psychological symptoms of dementia such as disturbances in mood, emotion, appetite, and wake– sleep cycle, confusion, agitation and depression have been less considered. The early occurrence of these symptoms suggests brainstem involvement, and more specifically of the serotonergic nuclei. In spite of the fact that the Braak staging system and National Institutes of Aging – Reagan Institute (NIA-RI) criteria do not include their evaluation, several recent reports drew attention to the possibility of selective and early involvement of raphe nuclei, particularly the dorsal raphe nucleus (DRN), in the pathogenesis of AD. Based on these findings of differential susceptibility and anatomical connectivity, a novel pathogenetic scheme of AD progression was proposed. Although the precise mechanisms of neurofibrillary degeneration still await elucidation, we speculated that cumulative oxidative damage may be the main cause of DRN alterations, as the age is the main risk factor for sporadic AD. Within such a framework, b-amyloid production is considered only as one of the factors (although a significant one in familial cases) that promotes molecular series of events underlying AD-related neuropathological changes.
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- 2009
11. Perspectives of translational neuroscience and announcement of the new journal Translational Neuroscience
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Šimić, Goran, Kostović, I., Jernej, B., Judaš, M., and Vukšić, M.
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neurology ,neuropsychology ,neuroscience ,neurosurgery ,translational research - Abstract
The main premise of my talk was that only through continuous investment and advances in basic biomedical and behavioral discoveries coupled with efficient translational science we can solve huge burden of neurological and psychiatric diseases today. The international, peer-review journal Translational Neuroscience was founded in accordance with our intention and hope to reinforce translational neuroscience research in order to ensure that extraordinary scientific advances of the past years will be rapidly captured, translated, and disseminated for the benefit of all people. Translational Neuroscience is aimed to provide a closer interaction between basic and clinical neuroscientists to further expand our understanding of brain structure, function and disease, and translate this knowledge into clinical applications and novel therapies of nervous system disorders. The journal is intended to be the premier source of high quality research that reports novel findings that are likely to change the direction of thinking and practice in biomedical sciences. The target audience of the journal are both basic and clinical neuroscientists, neurologists, neuropathologists, neuroanatomists, neurosurgeons, psychiatrists, psychologists, as well as graduate and postgraduate students in medicine and biology. It will cover research findings in all subfields of neuroscience (behavioral, cognitive, computational, developmental and regeneration, molecular, neural aging, neuroanatomy, neurobiology, neurochemistry, neuroendocrinology, neurogenetics, neuroimmunology, neuropathology, neuropharmacology, neurophysiology, methodology, neurotoxicology and systems neuroscience) as well as in the fields of neurology and neurosurgery. We hope that this new journal will represent international forum for the dissemination of research data aiming at the exchange of ideas thus facilitating the collaboration between researchers from different countries. We will offer unbiased, fast and comprehensive peer review, open access to the published articles, web-based manuscript submission system and free English language correction of grammar and style for authors. I invite you to help us in our efforts to make Translational Neuroscience an esteemed international journal by sending us your best work.
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- 2009
12. D2, D3 and D4 dopamine receptor expression in the prefrontal cortex of normal and schizophrenic brains
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Mladinov, Mihovil, Mayer, Davor, Jovanov-Milošević, Nataša, Kostović, Ivica, Šimić, Goran, Kostović, I, Jernej, B, Judaš, M, and Vukšić, M
- Subjects
confocal microscopy ,dopamine receptors ,expression pattern ,glia ,immunocytochemistry ,immunofluorescence ,prefrontal cortex ,pyramidal neurons ,schizophrenia - Abstract
The knowledge of the dopamine system is enormously important for understanding the human behavior, as well as for the pathophysiology of many neurological and psychiatric diseases. Functional disturbance of the midbrain dopamine trajectories to the prefrontal cortex (PFC) have been commonly implicated to psychiatric disorders like schizophrenia, autism, depression and drug abuse. So far, the majority of studies addressing the localization of dopamine receptors (DR) in the human brain used crude scintigraphic approach of ligand binding, while the precise anatomical localization of dopamine receptors in the PFC, particularly of the D2 group, has been largely neglected. Human brain tissue was taken during autopsy from 4 schizophrenic patients (age range: 51-59 years) and 3 age-matched controls (48-56 years) with no history of neurological and psychiatric disorders. Tissue specimens from the right orbitomedial PFC (BA11/12) of each brain were analyzed. The blocks were fixed in 4% paraformaldehyde, dehydrated, paraffin-embedded and cut in 12-micron thick sections. For immunocytochemistry the sections were stained using novel anti-DRD2, DRD3 and DRD4 antibodies. The specificity of the antibodies used was previously characterized by Wolstencroft, Šimić et al. in 2007. In schizophrenic brains, we found strong DRD2 immunoreactivity in pyramidal neurons of layer III and moderate in layer V pyramidal cells. Inversely, the expression of DRD4 was stronger in layer V pyramidal neurons. The expression of DRD3 was generally weaker than for DRD2 and DRD4. Contrary to normal controls, a significant number of DRD2-immunoreactive reactive astroglial cells, predominantly in the subcortical white matter, were found in all four schizophrenic brains. This finding represented the major difference in the dopamine receptors expression between normal and schizophrenic brains. Pyramidal cell expression of DR of the D2 group confirms that the activity of the prefrontal neuronal circuits is strongly modulated by dopamine transmission. The pronounced expression of the DRD2 receptors in reactive astrocytes of all four schizophrenic brains analyzed suggests its possible importance for the pathogenesis of schizophrenia.
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- 2009
13. L-shell X-ray production cross sections of Ag and Au induced by carbon ions between 2 MeV and 5 MeV
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Silhadi, H., Fazinić, Stjepko, Haidra, A., Zamboni, Ivana, Ouziane, S., Siketić, Z, Crnjac, A, Brajković, M, Barac, M, and Vukšić, M
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Nuclear and High Energy Physics ,ionization ,L-shell ,ECUSAR ,L-shell ionization, carbon ions, Ag, Au ,040103 agronomy & agriculture ,0401 agriculture, forestry, and fisheries ,04 agricultural and veterinary sciences ,Instrumentation - Abstract
In this work we experimentally determined Ag and Au L-Shell X-ray production cross sections by 2 to 5 MeV carbon ions. The measurements were performed using the standard measurement setup already used to measure M- Shell X-ray production cross sections [1]. Ag and Au thin targets were used and related X- ray spectra were measured with Si(Li) and SDD X-ray detectors simultaneously with the carbon backscattering spectra. The present new data are compared to the data available in the literature [2-3] as well as to theoretical predictions of ECPSSR [4] and ECUSAR [5] models. The analysis of data shows that the ECUSAR predictions are good at low carbon ion energies while the ECPSSR predictions agree at the higher incident energies. [1] A. Haidra, S. Fazini´c, S. Ouziane, I. Zamboni, D. Banas, Nucl. Instr. and Meth. B 440 (2019) 180-185. [2] D. Bhattacharya. M. Sarkar., M. B. chattarjee, P. Sen, G. Kuri, D .P. Mahapatra and G. Lapicki. Phy.Rev A 49 N 6 (1994) 4616-4622. [3] R. Mehta, H. L.Sun, D. K.Marble, J.L.Duggan, F. D. McDaniel and G. Lapicki, J.Phys.B. At Mol. Opt. Phys. 28 (1995)1187-1200. [4] W. Brandt, G. Lapicki, Phys. Rev. A 23 (1981) 1717–1729. [5] G. Lapicki, Phys. research B 189 (2002) 8- 20.
- Published
- 1999
14. Dynamics of the radiation induced defects in semiconductors studied by pulsed ion beams and micro RBS channeling
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Crnjac, A, Fazinić, S, Jakšić, M, Siketić, Z, Crnjac, A, Brajković, M, Barac, M, and Vukšić, M
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RBS channeling, ion microprobe, semiconductors - Abstract
Irradiation with pulsed ion beams is used to induce defects in semiconductor materials. Point defects are created around ion tracks in the crystal lattice. Pulsed pause time allows for defects recombinations before new radiation sequence. Defect dynamics are studied by varying pulsed pause times and controlling sample temperature. Relative number of defects in irradiated areas is quantified by means of RBS channeling technique, which was performed ex-situ. During channeling, beam spot size is focused to less than 10 micrometer dimension, and beam scanning allows to locate irradiated areas with RBSc used as the microscopic position sensitive technique. Experiment results are used to interpret the effect of beam pulsing time and sample temperature on the relative number of radiation induced defects in investigated semiconductor materials.
- Published
- 1999
15. Fetal development of the human amygdala.
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Mulc D, Smilović D, Krsnik Ž, Junaković-Munjas A, Kopić J, Kostović I, Šimić G, and Vukšić M
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- Female, Pregnancy, Humans, Prospective Studies, Fetal Development, Antibodies, Amygdala, Basolateral Nuclear Complex
- Abstract
The intricate development of the human amygdala involves a complex interplay of diverse processes, varying in speed and duration. In humans, transient cytoarchitectural structures deliquesce, leading to the formation of functionally distinct nuclei as a result of multiple interdependent developmental events. This study compares the amygdala's cytoarchitectural development in conjunction with specific antibody reactivity for neuronal, glial, neuropil, and radial glial fibers, synaptic, extracellular matrix, and myelin components in 39 fetal human brains. We recognized that the early fetal period, as a continuation of the embryonic period, is still dominated by relatively uniform histogenetic processes. The typical appearance of ovoid cell clusters in the lateral nucleus during midfetal period is most likely associated with the cell migration and axonal growth processes in the developing human brain. Notably, synaptic markers are firstly detected in the corticomedial group of nuclei, while immunoreactivity for the panaxonal neurofilament marker SMI 312 is found dorsally. The late fetal period is characterized by a protracted migration process evidenced by the presence of doublecortin and SOX-2 immunoreactivity ventrally, in the prospective paralaminar nucleus, reinforced by vimentin immunoreactivity in the last remaining radial glial fibers. Nearing the term period, SMI 99 immunoreactivity indicates that perinatal myelination becomes prominent primarily along major axonal pathways, laying the foundation for more pronounced functional maturation. This study comprehensively elucidates the rate and sequence of maturational events in the amygdala, highlighting the key role of prenatal development in its behavioral, autonomic, and endocrine regulation, with subsequent implications for both normal functioning and psychiatric disorders., (© 2024 Wiley Periodicals LLC.)
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- 2024
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16. Effect of Two-Step Sintering on Properties of Alumina Ceramics Containing Waste Alumina Powder.
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Vukšić M, Žmak I, Ćurković L, and Kocjan A
- Abstract
This study aims to evaluate the recycling potential of solid waste alumina powder (WAP) by utilization of the two-step sintering (TSS) process. For the study, WAP was collected as an industrial scrap after the machining process for the formation of green alumina compacts. The alumina samples were prepared according to the slip casting method by preparing suspensions containing commercial alumina with 0.8 μm average particle size and by adding up to 20 dwb. % (i.e., expressed on a dry weight basis) of WAP with 3.4 μm average particle size. The samples were sintered at optimized TSS conditions and compared with conventional one-step sintering (OSS) by conducting morphological analyses. The average grain size (AGS) was determined from the obtained field emission scanning electron microscopy (FESEM) images, while the sample porosity was calculated based on apparent densities. The obtained micrographs after TSS implementation revealed a partially textured microstructure. Furthermore, a comparison of the mechanical properties of alumina samples lacking or containing 20 dwb. % of WAP obtained after sintering is presented. The indentation fracture toughness (~3.2 MPa m
1/2 ) and Vickers hardness data (~14.5 GPa) showed a positive effect of adding WAP to alumina samples. The slightly improved mechanical properties of ceramic samples containing waste alumina are a consequence of lower porosity, which is due to the remaining sintering additives in WAP. The collected results demonstrate the possibility of using TSS for sintering ceramic materials that contain WAP.- Published
- 2022
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17. Prenatal development of the human entorhinal cortex.
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Šimić G, Krsnik Ž, Knezović V, Kelović Z, Mathiasen ML, Junaković A, Radoš M, Mulc D, Španić E, Quattrocolo G, Hall VJ, Zaborszky L, Vukšić M, Olucha Bordonau F, Kostović I, Witter MP, and Hof PR
- Subjects
- Adult, Female, Fetus, Hippocampus growth & development, Humans, Neurons metabolism, Pregnancy, Prospective Studies, Acetylcholinesterase metabolism, Entorhinal Cortex growth & development, Fetal Development
- Abstract
Little is known about the development of the human entorhinal cortex (EC), a major hub in a widespread network for learning and memory, spatial navigation, high-order processing of object information, multimodal integration, attention and awareness, emotion, motivation, and perception of time. We analyzed a series of 20 fetal and two adult human brains using Nissl stain, acetylcholinesterase (AChE) histochemistry, and immunocytochemistry for myelin basic protein (MBP), neuronal nuclei antigen (NeuN), a pan-axonal neurofilament marker, and synaptophysin, as well as postmortem 3T MRI. In comparison with other parts of the cerebral cortex, the cytoarchitectural differentiation of the EC begins remarkably early, in the 10th week of gestation (w.g.). The differentiation occurs in a superficial magnocellular layer in the deep part of the marginal zone, accompanied by cortical plate (CP) condensation and multilayering of the deep part of CP. These processes last until the 13-14th w.g. At 14 w.g., the superficial lamina dissecans (LD) is visible, which divides the CP into the lamina principalis externa (LPE) and interna (LPI). Simultaneously, the rostral LPE separates into vertical cell-dense islands, whereas in the LPI, the deep LD emerges as a clear acellular layer. In the 16th w.g., the LPE remodels into vertical cell-dense and cell-sparse zones with a caudorostral gradient. At 20 w.g., NeuN immunoreactivity is most pronounced in the islands of layer II cells, whereas migration and differentiation inside-out gradients are seen simultaneously in both the upper (LPE) and the lower (LPI) pyramidal layers. At this stage, the EC adopts for the first time an adult-like cytoarchitectural organization, the superficial LD becomes discernible by 3T MRI, MBP-expressing oligodendrocytes first appear in the fimbria and the perforant path (PP) penetrates the subiculum to reach its molecular layer and travels along through the Cornu Ammonis fields to reach the suprapyramidal blade of the dentate gyrus, whereas the entorhinal-dentate branch perforates the hippocampal sulcus about 2-3 weeks later. The first AChE reactivity appears as longitudinal stripes at 23 w.g. in layers I and II of the rostrolateral EC and then also as AChE-positive in-growing fibers in islands of superficial layer III and layer II neurons. At 40 w.g., myelination of the PP starts as patchy MBP-immunoreactive oligodendrocytes and their processes. Our results refute the possibility of an inside-out pattern of the EC development and support the key role of layer II prospective stellate cells in the EC lamination. As the early cytoarchitectural differentiation of the EC is paralleled by the neurochemical development, these developmental milestones in EC structure and connectivity have implications for understanding its normal function, including its puzzling modular organization and potential contribution to consciousness content (awareness), as well as for its insufficiently explored deficits in developmental, psychiatric, and degenerative brain disorders., (© 2022 Wiley Periodicals LLC.)
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- 2022
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18. Structural Changes in the Cortico-Ponto-Cerebellar Axis at Birth are Associated with Abnormal Neurological Outcomes in Childhood.
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Raguž M, Radoš M, Kostović Srzetić M, Kovačić N, Žunić Išasegi I, Benjak V, Ćaleta T, Vukšić M, and Kostović I
- Subjects
- Child, Preschool, Diffusion Magnetic Resonance Imaging, Female, Humans, Infant, Newborn, Pons, Pregnancy, Prospective Studies, Cerebellum diagnostic imaging, Infant, Premature
- Abstract
White matter lesions in hypoxic-ischemic encephalopathy (HIE) are considered to be the important substrate of frequent neurological consequences in preterm infants. The aim of the study was to analyze volumes and tractographic parameters of the cortico-ponto-cerebellar axis to assess alterations in the periventricular fiber system and crossroads, corticopontine and corticospinal pathways and prospective transsynaptic changes of the cerebellum.Term infants (control), premature infants without (normotypic) and with perinatal HIE (HIE) underwent brain magnetic resonance imaging at term-equivalent age (TEA) and at 2 years. Cerebrum, cerebellum, brainstem divisions and ventrodorsal compartments volumetric analysis were performed, as well as fractional anisotropy (FA) and apparent diffusion coefficient (ADC) of corticopontine, corticospinal pathways and middle cerebellar peduncles. Amiel-Tison scale at TEA and the Hempel test at 2 years were assessed.Cerebellum, brainstem and its compartments volumes were decreased in normotypic and HIE groups at TEA, while at 2 years volumes were significantly reduced in the HIE group, accompanied by decreased volume and FA and increased ADC of corticopontine and corticospinal pathways. Negative association of the brainstem, cerebellum, mesencephalon, pons, corticopontine volumes and corticospinal pathway FA at TEA with the neurological score at 2 years. Cerebellum and pons volumes presented as potential prognostic indicators of neurological outcomes.Our findings agree that these pathways, as a part of the periventricular fiber system and crossroads, exhibit lesion-induced reaction and vulnerability in HIE. Structural differences between normotypic and HIE group at the 2 years suggest a different developmental structural plasticity., (© 2021. Springer-Verlag GmbH Germany, part of Springer Nature.)
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- 2021
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19. Understanding Emotions: Origins and Roles of the Amygdala.
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Šimić G, Tkalčić M, Vukić V, Mulc D, Španić E, Šagud M, Olucha-Bordonau FE, Vukšić M, and R Hof P
- Subjects
- Humans, Amygdala physiology, Emotions physiology
- Abstract
Emotions arise from activations of specialized neuronal populations in several parts of the cerebral cortex, notably the anterior cingulate, insula, ventromedial prefrontal, and subcortical structures, such as the amygdala, ventral striatum, putamen, caudate nucleus, and ventral tegmental area. Feelings are conscious, emotional experiences of these activations that contribute to neuronal networks mediating thoughts, language, and behavior, thus enhancing the ability to predict, learn, and reappraise stimuli and situations in the environment based on previous experiences. Contemporary theories of emotion converge around the key role of the amygdala as the central subcortical emotional brain structure that constantly evaluates and integrates a variety of sensory information from the surroundings and assigns them appropriate values of emotional dimensions, such as valence, intensity, and approachability. The amygdala participates in the regulation of autonomic and endocrine functions, decision-making and adaptations of instinctive and motivational behaviors to changes in the environment through implicit associative learning, changes in short- and long-term synaptic plasticity, and activation of the fight-or-flight response via efferent projections from its central nucleus to cortical and subcortical structures.
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- 2021
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20. Corrigendum to: Histological and MRI Study of the Development of the Human Indusium Griseum.
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Rasonja MB, Orešković D, Knezović V, Pogledić I, Pupačić D, Vukšić M, Brugger PC, Prayer D, Petanjek Z, and Milošević NJ
- Published
- 2021
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21. Histological and MRI Study of the Development of the Human Indusium Griseum.
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Bobić Rasonja M, Orešković D, Knezović V, Pogledić I, Pupačić D, Vukšić M, Brugger PC, Prayer D, Petanjek Z, and Jovanov Milošević N
- Subjects
- Cell Count, Cell Differentiation, Female, Histological Techniques, Humans, Magnetic Resonance Imaging, Male, Limbic Lobe cytology, Limbic Lobe embryology, Neurons cytology, Neurons physiology
- Abstract
To uncover the ontogenesis of the human indusium griseum (IG), 28 post-mortem fetal human brains, 12-40 postconceptional weeks (PCW) of age, and 4 adult brains were analyzed immunohistochemically and compared with post-mortem magnetic resonance imaging (MRI) of 28 fetal brains (14-41 PCW). The morphogenesis of the IG occurred between 12 and 15 PCW, transforming the bilateral IG primordia into a ribbon-like cortical lamina. The histogenetic transition of sub-laminated zones into the three-layered cortical organization occurred between 15 and 35 PCW, concomitantly with rapid cell differentiation that occurred from 18 to 28 PCW and the elaboration of neuronal connectivity during the entire second half of gestation. The increasing number of total cells and neurons in the IG at 25 and 35 PCW confirmed its continued differentiation throughout this period. High-field 3.0 T post-mortem MRI enabled visualization of the IG at the mid-fetal stage using T2-weighted sequences. In conclusion, the IG had a distinct histogenetic differentiation pattern than that of the neighboring intralimbic areas of the same ontogenetic origin, and did not show any signs of regression during the fetal period or postnatally, implying a functional role of the IG in the adult brain, which is yet to be disclosed., (© The Author(s) 2019. Published by Oxford University Press. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.)
- Published
- 2019
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22. Exploitation of thermal gradients for investigation of irradiation temperature effects with charged particles.
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Hardie CD, London AJ, Lim JJH, Bamber R, Tadić T, Vukšić M, and Fazinić S
- Abstract
The effects of radiation damage on materials are strongly dependant on temperature, making it arguably the most significant parameter of concern in nuclear engineering. Owing to the challenges and expense of irradiating and testing materials, material property data is often limited to few irradiation conditions and material variants. A new technique has been developed which enables the investigation of radiation damage of samples subject to a thermal gradient, whereby a wealth of data over a range of irradiation temperatures is produced from a single irradiation experiment. The results produced are practically inaccessible by use of multiple conventional isothermal irradiations. We present a precipitation-hardened copper alloy (CuCrZr) case-study irradiated with a linear temperature gradient between 125 and 440 °C. Subsequent micro-scale post irradiation characterisation (nanoindentation, transmission electron microscopy and atom probe tomography) highlight the capability to observe mechanical and microstructural changes over a wide range of irradiation temperatures. We observed irradiation-softening in CuCrZr that did not occur due to irradiation-enhanced aging of the Cr-precipitates. Excellent reproducibility of the new technique was demonstrated and replicated irradiation-hardening data from several isothermal neutron irradiation studies. Our new technique provides this data at a fraction of the time and cost required by conventional irradiation experiments.
- Published
- 2019
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23. Effect of Additives on Stability of Alumina-Waste Alumina Suspension for Slip Casting: Optimization Using Box-Behnken Design.
- Author
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Vukšić M, Žmak I, Ćurković L, and Ćorić D
- Abstract
The green machining of alumina (Al
2 O3 ) green bodies generates a certain amount of waste alumina powder. Waste alumina ceramic powder should be disposed of as non-hazardous waste in a legally compliant manner. The influence of additives on the stability of 70 wt.% (≈40 vol.%) alumina-waste alumina water-based suspension was investigated in the presented research. A Box-Behnken three-factor response surface design was used for the preparation of stable highly-concentrated suspensions with the addition of three additives. The optimal amount of each additive was selected according to the obtained results of minimal apparent viscosity: 0.05 wt.% Tiron as dispersant, 0.1 wt.% poly (vinyl alcohol) as binder and 0.2 wt.% magnesium aluminate spinel as abnormal grain growth inhibitor. The analysis of variance was used to identify the contribution of each additive. The zeta potential and sedimentations tests were performed to confirm the suspension stability measurements at different pH values. Alumina particles were optimally dispersed at pH values between 8 and 11. According to the results, the investigated composition of 20 wt.% waste alumina powder (weight content, dry alumina powder), with the addition of optimal amounts of additives, shows a possible application in the production of ceramics by slip casting.- Published
- 2019
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24. Underdevelopment of the Human Hippocampus in Callosal Agenesis: An In Vivo Fetal MRI Study.
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Knezović V, Kasprian G, Štajduhar A, Schwartz E, Weber M, Gruber GM, Brugger PC, Prayer D, and Vukšić M
- Subjects
- Agenesis of Corpus Callosum pathology, Corpus Callosum diagnostic imaging, Corpus Callosum embryology, Corpus Callosum pathology, Female, Fetus pathology, Hippocampus embryology, Hippocampus pathology, Humans, Magnetic Resonance Imaging methods, Male, Neuroimaging, Pregnancy, Agenesis of Corpus Callosum diagnostic imaging, Fetus diagnostic imaging, Hippocampus diagnostic imaging
- Abstract
Background and Purpose: In subjects with agenesis of the corpus callosum, a variety of structural brain alterations is already present during prenatal life. Quantification of these alterations in fetuses with associated brain or body malformations (corpus callosum agenesis and other related anomalies) and so-called isolated cases may help to optimize the challenging prognostic prenatal assessment of fetuses with corpus callosum agenesis. This fetal MR imaging study aimed to identify differences in the size of the prenatal hippocampus between subjects with isolated corpus callosum agenesis, corpus callosum agenesis and other related anomalies, and healthy controls., Materials and Methods: Eighty-five in utero fetal brain MR imaging scans, (20-35 gestational weeks) were postprocessed using a high-resolution algorithm. On the basis of multiplanar T2-TSE sequences, 3D isovoxel datasets were generated, and both hippocampi and the intracranial volume were segmented., Results: Hippocampal volumes increased linearly with gestational weeks in all 3 groups. One-way ANOVA demonstrated differences in hippocampal volumes between control and pathologic groups (isolated corpus callosum agenesis: left, P = .02; right, P = .04; corpus callosum agenesis and other related anomalies: P < .001). Differences among the pathologic groups were also present for both sides. Intracranial volume and right and left hippocampal volume ratios were different between corpus callosum agenesis cases and controls ( P < .001). When we corrected for intracranial volume, no differences were found between corpus callosum agenesis and other associated anomalies and isolated corpus callosum agenesis (left, P = .77; right, P = .84). Hippocampal size differences were more pronounced at a later gestational age., Conclusions: Callosal agenesis apparently interferes with the normal process of hippocampal formation and growth, resulting in underdevelopment, which could account for certain learning and memory deficits in individuals with agenesis of the corpus callosum in later life., (© 2019 by American Journal of Neuroradiology.)
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- 2019
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25. The Zagreb Collection of human brains: entering the virtual world.
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Hrabač P, Bosak A, Vukšić M, Judaš M, Kostović I, and Krsnik Ž
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- Croatia, History, 20th Century, History, 21st Century, Humans, Information Storage and Retrieval, Biological Specimen Banks history, Brain anatomy & histology, Computer Systems, Histology, Software
- Published
- 2018
26. Ion Microbeam Analyses of Dust Particles and Codeposits from JET with the ITER-Like Wall.
- Author
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Fazinić S, Tadić T, Vukšić M, Rubel M, Petersson P, Fortuna-Zaleśna E, and Widdowson A
- Abstract
Generation of metal dust in the JET tokamak with the ITER-like wall (ILW) is a topic of vital interest to next-step fusion devices because of safety issues with plasma operation. Simultaneous Nuclear Reaction Analysis (NRA) and Particle-Induced X-ray Emission (PIXE) with a focused four MeV
3 He microbeam was used to determine the composition of dust particles related to the JET operation with the ILW. The focus was on "Be-rich particles" collected from the deposition zone on the inner divertor tile. The particles found are composed of a mix of codeposited species up to 120 μm in size with a thickness of 30-40 μm. The main constituents are D from the fusion fuel, Be and W from the main plasma-facing components, and Ni and Cr from the Inconel grills of the antennas for auxiliary plasma heating. Elemental concentrations were estimated by iterative NRA-PIXE analysis. Two types of dust particles were found: (i) larger Be-rich particles with Be concentrations above 90 at% with a deuterium presence of up to 3.4 at% and containing Ni (1-3 at%), Cr (0.4-0.8 at%), W (0.2-0.9 at%), Fe (0.3-0.6 at%), and Cu and Ti in lower concentrations and (ii) small particles rich in Al and/or Si that were in some cases accompanied by other elements, such as Fe, Cu, or Ti or W and Mo.- Published
- 2018
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27. Coevolution in the timing of GABAergic and pyramidal neuron maturation in primates.
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Charvet CJ, Šimić G, Kostović I, Knezović V, Vukšić M, Babić Leko M, Takahashi E, Sherwood CC, Wolfe MD, and Finlay BL
- Subjects
- Animals, Brain cytology, Humans, Macaca physiology, Mice, Rats, Biological Coevolution, GABAergic Neurons cytology, Neurogenesis, Pyramidal Cells cytology
- Abstract
The cortex of primates is relatively expanded compared with many other mammals, yet little is known about what developmental processes account for the expansion of cortical subtype numbers in primates, including humans. We asked whether GABAergic and pyramidal neuron production occurs for longer than expected in primates than in mice in a sample of 86 developing primate and rodent brains. We use high-resolution structural, diffusion MR scans and histological material to compare the timing of the ganglionic eminences (GE) and cortical proliferative pool (CPP) maturation between humans, macaques, rats, and mice. We also compare the timing of post-neurogenetic maturation of GABAergic and pyramidal neurons in primates (i.e. humans, macaques) relative to rats and mice to identify whether delays in neurogenesis are concomitant with delayed post-neurogenetic maturation. We found that the growth of the GE and CPP are both selectively delayed compared with other events in primates. By contrast, the timing of post-neurogenetic GABAergic and pyramidal events (e.g. synaptogenesis) are predictable from the timing of other events in primates and in studied rodents. The extended duration of GABAergic and pyramidal neuron production is associated with the amplification of GABAerigc and pyramidal neuron numbers in the human and non-human primate cortex., (© 2017 The Author(s).)
- Published
- 2017
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28. The relevance of human fetal subplate zone for developmental neuropathology of neuronal migration disorders and cortical dysplasia.
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Kostović I, Sedmak G, Vukšić M, and Judaš M
- Subjects
- Cell Movement physiology, Humans, Neurons physiology, Cerebral Cortex embryology, Cerebral Cortex pathology, Malformations of Cortical Development pathology, Malformations of Cortical Development, Group II pathology
- Abstract
The human fetal cerebral cortex develops through a series of partially overlapping histogenetic events which occur in transient cellular compartments, such as the subplate zone. The subplate serves as waiting compartment for cortical afferent fibers, the major site of early synaptogenesis and neuronal differentiation and the hub of the transient fetal cortical circuitry. Thus, the subplate has an important but hitherto neglected role in the human fetal cortical connectome. The subplate is also an important compartment for radial and tangential migration of future cortical neurons. We review the diversity of subplate neuronal phenotypes and their involvement in cortical circuitry and discuss the complexity of late neuronal migration through the subplate as well as its potential relevance for pathogenesis of migration disorders and cortical dysplasia. While migratory neurons may become misplaced within the subplate, they can easily survive by being involved in early subplate circuitry; this can enhance their subsequent survival even if they have immature or abnormal physiological activity and misrouted connections and thus survive into adulthood. Thus, better understanding of subplate developmental history and various subsets of its neurons may help to elucidate certain types of neuronal disorders, including those accompanied by epilepsy., (© 2014 John Wiley & Sons Ltd.)
- Published
- 2015
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29. Human fetal tau protein isoform: possibilities for Alzheimer's disease treatment.
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Jovanov-Milošević N, Petrović D, Sedmak G, Vukšić M, Hof PR, and Simić G
- Subjects
- Alzheimer Disease genetics, Alzheimer Disease prevention & control, Animals, Brain pathology, Gene Expression Regulation, Developmental, Humans, Mice, Phosphorylation, Protein Isoforms genetics, Protein Isoforms metabolism, tau Proteins genetics, Alzheimer Disease metabolism, Brain metabolism, Fetus metabolism, tau Proteins metabolism
- Abstract
While early 1990s reports showed the phosphorylation pattern of fetal tau protein to be similar to that of tau in paired helical filaments (PHF) in Alzheimer's disease (AD), neither the molecular mechanisms of the transient developmental hyperphosphorylation of tau nor reactivation of the fetal plasticity due to re-expression of fetal protein kinases in the aging and AD human brain have been sufficiently investigated. Here, we summarize the current knowledge on fetal tau, adding new data on the specific patterns of tau protein and mRNA expression in the developing human brain as well as on change in tau phosphorylation in the perforant pathway after entorhinal cortex lesion in mice. As fetal tau isoform does not form PHF even in a highly phosphorylated state, understanding its expression and post-translational modifications represents an important avenue for future research towards the development of AD treatment and prevention., (Copyright © 2012 Elsevier Ltd. All rights reserved.)
- Published
- 2012
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30. The Zagreb Collection of human brains: a unique, versatile, but underexploited resource for the neuroscience community.
- Author
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Judaš M, Šimić G, Petanjek Z, Jovanov-Milošević N, Pletikos M, Vasung L, Vukšić M, and Kostović I
- Subjects
- Academies and Institutes, Adult, Anatomy, Cross-Sectional, Biomedical Research, Brain embryology, Brain growth & development, Child, Croatia, Embryo, Mammalian anatomy & histology, Female, Fetus anatomy & histology, History, 20th Century, History, 21st Century, Humans, Male, Neurons cytology, Biological Specimen Banks history, Biological Specimen Banks organization & administration, Brain anatomy & histology
- Abstract
The Zagreb Collection of developing and adult human brains was founded in 1974 by Ivica Kostović and consists of 1,278 developing and adult human brains, including 610 fetal, 317 children, and 359 adult brains. It is one of the largest collections of developing human brains. The collection serves as a key resource for many focused research projects and has led to several seminal contributions on mammalian cortical development, such as the discovery of the transient fetal subplate zone and of early bilaminar synaptogenesis in the embryonic and fetal human cerebral cortex, and the first description of growing afferent pathways in the human fetal telencephalon. The Zagreb Collection also serves as a core resource for ever-growing networks of international collaboration and represents the starting point for many young investigators who now pursue independent research careers at leading international institutions. The Zagreb Collection, however, remains underexploited owing to a lack of adequate funding in Croatia. Funding could establish an online catalog of the collection and modern virtual microscopy scanning methods to make the collection internationally more accessible., (© 2011 New York Academy of Sciences.)
- Published
- 2011
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