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10 results on '"Vrousgou, Olga"'

1. Practical Contextual Bandits with Feedback Graphs

Author

Zhang, Mengxiao, Zhang, Yuheng, Vrousgou, Olga, Luo, Haipeng, and Mineiro, Paul

Subjects
Computer Science - Machine Learning
Abstract

While contextual bandit has a mature theory, effectively leveraging different feedback patterns to enhance the pace of learning remains unclear. Bandits with feedback graphs, which interpolates between the full information and bandit regimes, provides a promising framework to mitigate the statistical complexity of learning. In this paper, we propose and analyze an approach to contextual bandits with feedback graphs based upon reduction to regression. The resulting algorithms are computationally practical and achieve established minimax rates, thereby reducing the statistical complexity in real-world applications.

Published
2023

2. A Grid-Enabled Modular Framework for Efficient Sequence Analysis Workflows

Author

Vrousgou, Olga T., Psomopoulos, Fotis E., Mitkas, Pericles A., Diniz Junqueira Barbosa, Simone, Series editor, Chen, Phoebe, Series editor, Du, Xiaoyong, Series editor, Filipe, Joaquim, Series editor, Kara, Orhun, Series editor, Kotenko, Igor, Series editor, Liu, Ting, Series editor, Sivalingam, Krishna M., Series editor, Washio, Takashi, Series editor, Iliadis, Lazaros, editor, and Jayne, Chrisina, editor

Published
2015
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4. Open Targets Genetics: systematic identification of trait-associated genes using large-scale genetics and functional genomics

Author

Ghoussaini, Maya, primary, Mountjoy, Edward, additional, Carmona, Miguel, additional, Peat, Gareth, additional, Schmidt, Ellen M, additional, Hercules, Andrew, additional, Fumis, Luca, additional, Miranda, Alfredo, additional, Carvalho-Silva, Denise, additional, Buniello, Annalisa, additional, Burdett, Tony, additional, Hayhurst, James, additional, Baker, Jarrod, additional, Ferrer, Javier, additional, Gonzalez-Uriarte, Asier, additional, Jupp, Simon, additional, Karim, Mohd Anisul, additional, Koscielny, Gautier, additional, Machlitt-Northen, Sandra, additional, Malangone, Cinzia, additional, Pendlington, Zoe May, additional, Roncaglia, Paola, additional, Suveges, Daniel, additional, Wright, Daniel, additional, Vrousgou, Olga, additional, Papa, Eliseo, additional, Parkinson, Helen, additional, MacArthur, Jacqueline A L, additional, Todd, John A, additional, Barrett, Jeffrey C, additional, Schwartzentruber, Jeremy, additional, Hulcoop, David G, additional, Ochoa, David, additional, McDonagh, Ellen M, additional, and Dunham, Ian, additional

Published
2020
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5. The NHGRI-EBI GWAS Catalog of published genome-wide association studies, targeted arrays and summary statistics 2019

Author

Buniello, Annalisa, primary, MacArthur, Jacqueline A L, additional, Cerezo, Maria, additional, Harris, Laura W, additional, Hayhurst, James, additional, Malangone, Cinzia, additional, McMahon, Aoife, additional, Morales, Joannella, additional, Mountjoy, Edward, additional, Sollis, Elliot, additional, Suveges, Daniel, additional, Vrousgou, Olga, additional, Whetzel, Patricia L, additional, Amode, Ridwan, additional, Guillen, Jose A, additional, Riat, Harpreet S, additional, Trevanion, Stephen J, additional, Hall, Peggy, additional, Junkins, Heather, additional, Flicek, Paul, additional, Burdett, Tony, additional, Hindorff, Lucia A, additional, Cunningham, Fiona, additional, and Parkinson, Helen, additional

Published
2018
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7. Open Targets: a platform for therapeutic target identification and validation

Author

Koscielny, Gautier, primary, An, Peter, additional, Carvalho-Silva, Denise, additional, Cham, Jennifer A., additional, Fumis, Luca, additional, Gasparyan, Rippa, additional, Hasan, Samiul, additional, Karamanis, Nikiforos, additional, Maguire, Michael, additional, Papa, Eliseo, additional, Pierleoni, Andrea, additional, Pignatelli, Miguel, additional, Platt, Theo, additional, Rowland, Francis, additional, Wankar, Priyanka, additional, Bento, A. Patrícia, additional, Burdett, Tony, additional, Fabregat, Antonio, additional, Forbes, Simon, additional, Gaulton, Anna, additional, Gonzalez, Cristina Yenyxe, additional, Hermjakob, Henning, additional, Hersey, Anne, additional, Jupe, Steven, additional, Kafkas, Şenay, additional, Keays, Maria, additional, Leroy, Catherine, additional, Lopez, Francisco-Javier, additional, Magarinos, Maria Paula, additional, Malone, James, additional, McEntyre, Johanna, additional, Munoz-Pomer Fuentes, Alfonso, additional, O'Donovan, Claire, additional, Papatheodorou, Irene, additional, Parkinson, Helen, additional, Palka, Barbara, additional, Paschall, Justin, additional, Petryszak, Robert, additional, Pratanwanich, Naruemon, additional, Sarntivijal, Sirarat, additional, Saunders, Gary, additional, Sidiropoulos, Konstantinos, additional, Smith, Thomas, additional, Sondka, Zbyslaw, additional, Stegle, Oliver, additional, Tang, Y. Amy, additional, Turner, Edward, additional, Vaughan, Brendan, additional, Vrousgou, Olga, additional, Watkins, Xavier, additional, Martin, Maria-Jesus, additional, Sanseau, Philippe, additional, Vamathevan, Jessica, additional, Birney, Ewan, additional, Barrett, Jeffrey, additional, and Dunham, Ian, additional

Published
2016
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8. The NHGRI-EBI GWAS Catalog of published genome-wide association studies, targeted arrays and summary statistics 2019.

Author

Buniello, Annalisa, MacArthur, Jacqueline A L, Cerezo, Maria, Harris, Laura W, Hayhurst, James, Malangone, Cinzia, McMahon, Aoife, Morales, Joannella, Mountjoy, Edward, Sollis, Elliot, Suveges, Daniel, Vrousgou, Olga, Whetzel, Patricia L, Amode, Ridwan, Guillen, Jose A, Riat, Harpreet S, Trevanion, Stephen J, Hall, Peggy, Junkins, Heather, and Flicek, Paul

Published
2019
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9. Open Targets Genetics: systematic identification of trait-associated genes using large-scale genetics and functional genomics.

Author

Ghoussaini M, Mountjoy E, Carmona M, Peat G, Schmidt EM, Hercules A, Fumis L, Miranda A, Carvalho-Silva D, Buniello A, Burdett T, Hayhurst J, Baker J, Ferrer J, Gonzalez-Uriarte A, Jupp S, Karim MA, Koscielny G, Machlitt-Northen S, Malangone C, Pendlington ZM, Roncaglia P, Suveges D, Wright D, Vrousgou O, Papa E, Parkinson H, MacArthur JAL, Todd JA, Barrett JC, Schwartzentruber J, Hulcoop DG, Ochoa D, McDonagh EM, and Dunham I

Subjects
Chromatin chemistry, Chromatin metabolism, Datasets as Topic, Drug Discovery methods, Drug Repositioning methods, Genome-Wide Association Study, Genotype, Humans, Inflammatory Bowel Diseases drug therapy, Inflammatory Bowel Diseases metabolism, Inflammatory Bowel Diseases pathology, Internet, Phenotype, Quantitative Trait, Heritable, Databases, Genetic, Genome, Human, Inflammatory Bowel Diseases genetics, Molecular Targeted Therapy methods, Quantitative Trait Loci, Software
Abstract

Open Targets Genetics (https://genetics.opentargets.org) is an open-access integrative resource that aggregates human GWAS and functional genomics data including gene expression, protein abundance, chromatin interaction and conformation data from a wide range of cell types and tissues to make robust connections between GWAS-associated loci, variants and likely causal genes. This enables systematic identification and prioritisation of likely causal variants and genes across all published trait-associated loci. In this paper, we describe the public resources we aggregate, the technology and analyses we use, and the functionality that the portal offers. Open Targets Genetics can be searched by variant, gene or study/phenotype. It offers tools that enable users to prioritise causal variants and genes at disease-associated loci and access systematic cross-disease and disease-molecular trait colocalization analysis across 92 cell types and tissues including the eQTL Catalogue. Data visualizations such as Manhattan-like plots, regional plots, credible sets overlap between studies and PheWAS plots enable users to explore GWAS signals in depth. The integrated data is made available through the web portal, for bulk download and via a GraphQL API, and the software is open source. Applications of this integrated data include identification of novel targets for drug discovery and drug repurposing., (© The Author(s) 2020. Published by Oxford University Press on behalf of Nucleic Acids Research.)

Published
2021
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10. Open Targets: a platform for therapeutic target identification and validation.

Author

Koscielny G, An P, Carvalho-Silva D, Cham JA, Fumis L, Gasparyan R, Hasan S, Karamanis N, Maguire M, Papa E, Pierleoni A, Pignatelli M, Platt T, Rowland F, Wankar P, Bento AP, Burdett T, Fabregat A, Forbes S, Gaulton A, Gonzalez CY, Hermjakob H, Hersey A, Jupe S, Kafkas Ş, Keays M, Leroy C, Lopez FJ, Magarinos MP, Malone J, McEntyre J, Munoz-Pomer Fuentes A, O'Donovan C, Papatheodorou I, Parkinson H, Palka B, Paschall J, Petryszak R, Pratanwanich N, Sarntivijal S, Saunders G, Sidiropoulos K, Smith T, Sondka Z, Stegle O, Tang YA, Turner E, Vaughan B, Vrousgou O, Watkins X, Martin MJ, Sanseau P, Vamathevan J, Birney E, Barrett J, and Dunham I

Subjects
Databases, Factual, Humans, Reproducibility of Results, Web Browser, Workflow, Computational Biology methods, Molecular Targeted Therapy methods, Search Engine, Software
Abstract

We have designed and developed a data integration and visualization platform that provides evidence about the association of known and potential drug targets with diseases. The platform is designed to support identification and prioritization of biological targets for follow-up. Each drug target is linked to a disease using integrated genome-wide data from a broad range of data sources. The platform provides either a target-centric workflow to identify diseases that may be associated with a specific target, or a disease-centric workflow to identify targets that may be associated with a specific disease. Users can easily transition between these target- and disease-centric workflows. The Open Targets Validation Platform is accessible at https://www.targetvalidation.org., (© The Author(s) 2016. Published by Oxford University Press on behalf of Nucleic Acids Research.)

Published
2017
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