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3. Prediction of Outcome and Endovascular Treatment Benefit

Author

Venema, Esmee, Roozenbeek, Bob, Mulder, Maxim JHL, Brown, Scott, Majoie, Charles BLM, Steyerberg, Ewout W, Demchuk, Andrew M, Muir, Keith W, Dávalos, Antoni, Mitchell, Peter J, Bracard, Serge, Berkhemer, Olvert A, Lycklama à Nijeholt, Geert J, van Oostenbrugge, Robert J, Roos, Yvo BWEM, van Zwam, Wim H, van der Lugt, Aad, Hill, Michael D, White, Philip, Campbell, Bruce CV, Guillemin, Francis, Saver, Jeffrey L, Jovin, Tudor G, Goyal, Mayank, Dippel, Diederik WJ, Lingsma, Hester F, der Lugt, Aad van, Boiten, Jelis, Vos, Jan Albert, Jansen, Ivo GH, Goldhoorn, Robert-Jan B, Compagne, Kars CJ, Kappelhof, Manon, Brouwer, Josje, den Hartog, Sanne J, Hinsenveld, Wouter H, van Es, Adriaan CGM, Emmer, Bart J, Coutinho, Jonathan M, Schonewille, Wouter J, Wermer, Marieke JH, van Walderveen, Marianne AA, Staals, Julie, Hofmeijer, Jeannette, Martens, Jasper M, de Bruijn, Sebastiaan F, van Dijk, Lukas C, van der Worp, H Bart, Lo, Rob H, van Dijk, Ewoud J, Boogaarts, Hieronymus D, Vries, J de, de Kort, Paul LM, van Tuijl, Julia, Peluso, Jo P, Fransen, Puck, van den Berg, Jan SP, van Hasselt, Boudewijn AAM, Aerden, Leo AM, Dallinga, René J, Uyttenboogaart, Maarten, Eschgi, Omid, Bokkers, Reinoud PH, Schreuder, Tobien HCML, Heijboer, Roel JJ, Keizer, Koos, Yo, Lonneke SF, den Hertog, Heleen M, Bulut, Tomas, Brouwers, Paul JAM, Sprengers, Marieke ES, Jenniskens, Sjoerd FM, van den Berg, René, Yoo, Albert J, Beenen, Ludo FM, Postma, Alida A, Roosendaal, Stefan D, van der Kallen, Bas FW, van den Wijngaard, Ido R, Bot, Joost, van Doormaal, Pieter-Jan, Meijer, Anton, Ghariq, Elyas, van Proosdij, Marc P, Krietemeijer, G Menno, Lo, Rob, Gerrits, Dick, Dinkelaar, Wouter, and Appelman, Auke PA

Subjects
Clinical Trials and Supportive Activities, Clinical Research, Stroke, Brain Disorders, Neurosciences, Aged, Aged, 80 and over, Brain Ischemia, Endovascular Procedures, Humans, Ischemic Stroke, Male, Middle Aged, Registries, Thrombectomy, Treatment Outcome, ischemic stroke, registry, reperfusion, thrombectomy, uncertainty, HERMES collaborators and MR CLEAN Registry Investigators*, Cardiorespiratory Medicine and Haematology, Clinical Sciences, Neurology & Neurosurgery
Abstract

Background and purposeBenefit of early endovascular treatment (EVT) for ischemic stroke varies considerably among patients. The MR PREDICTS decision tool, derived from MR CLEAN (Multicenter Randomized Clinical Trial of Endovascular Treatment for Acute Ischemic Stroke in the Netherlands), predicts outcome and treatment benefit based on baseline characteristics. Our aim was to externally validate and update MR PREDICTS with data from international trials and daily clinical practice.MethodsWe used individual patient data from 6 randomized controlled trials within the HERMES (Highly Effective Reperfusion Evaluated in Multiple Endovascular Stroke Trials) collaboration to validate the original model. Then, we updated the model and performed a second validation with data from the observational MR CLEAN Registry. Primary outcome was functional independence (defined as modified Rankin Scale score 0–2) 3 months after stroke. Treatment benefit was defined as the difference between the probability of functional independence with and without EVT. Discriminative performance was evaluated using a concordance (C) statistic.ResultsWe included 1242 patients from HERMES (633 assigned to EVT, 609 assigned to control) and 3156 patients from the MR CLEAN Registry (all of whom underwent EVT within 6.5 hours). The C-statistic for functional independence was 0.74 (95% CI, 0.72–0.77) in HERMES and, after model updating, 0.80 (0.78–0.82) in the Registry. Median predicted treatment benefit of routinely treated patients (Registry) was 10.3% (interquartile range, 5.8%–14.4%). Patients with low (

Published
2021

4. Display of the human mucinome with defined O-glycans by gene engineered cells

Author

Nason, Rebecca, Büll, Christian, Konstantinidi, Andriana, Sun, Lingbo, Ye, Zilu, Halim, Adnan, Du, Wenjuan, Sørensen, Daniel M, Durbesson, Fabien, Furukawa, Sanae, Mandel, Ulla, Joshi, Hiren J, Dworkin, Leo Alexander, Hansen, Lars, David, Leonor, Iverson, Tina M, Bensing, Barbara A, Sullam, Paul M, Varki, Ajit, Vries, Erik de, de Haan, Cornelis AM, Vincentelli, Renaud, Henrissat, Bernard, Vakhrushev, Sergey Y, Clausen, Henrik, and Narimatsu, Yoshiki

Subjects
Rare Diseases, Genetic Engineering, Glycosylation, HEK293 Cells, Humans, Microbiota, Mucin-1, Mucins, Mucous Membrane, Polysaccharides
Abstract

Mucins are a large family of heavily O-glycosylated proteins that cover all mucosal surfaces and constitute the major macromolecules in most body fluids. Mucins are primarily defined by their variable tandem repeat (TR) domains that are densely decorated with different O-glycan structures in distinct patterns, and these arguably convey much of the informational content of mucins. Here, we develop a cell-based platform for the display and production of human TR O-glycodomains (~200 amino acids) with tunable structures and patterns of O-glycans using membrane-bound and secreted reporters expressed in glycoengineered HEK293 cells. Availability of defined mucin TR O-glycodomains advances experimental studies into the versatile role of mucins at the interface with pathogenic microorganisms and the microbiome, and sparks new strategies for molecular dissection of specific roles of adhesins, glycoside hydrolases, glycopeptidases, viruses and other interactions with mucin TRs as highlighted by examples.

Published
2021

6. Genetic association analysis identifies variants associated with disease progression in primary sclerosing cholangitis

Author

Alberts, Rudi, de Vries, Elisabeth MG, Goode, Elizabeth C, Jiang, Xiaojun, Sampaziotis, Fotis, Rombouts, Krista, Böttcher, Katrin, Folseraas, Trine, Weismüller, Tobias J, Mason, Andrew L, Wang, Weiwei, Alexander, Graeme, Alvaro, Domenico, Bergquist, Annika, Björkström, Niklas K, Beuers, Ulrich, Björnsson, Einar, Boberg, Kirsten Muri, Bowlus, Christopher L, Bragazzi, Maria C, Carbone, Marco, Chazouillères, Olivier, Cheung, Angela, Dalekos, Georgios, Eaton, John, Eksteen, Bertus, Ellinghaus, David, Färkkilä, Martti, Festen, Eleonora AM, Floreani, Annarosa, Franceschet, Irene, Gotthardt, Daniel Nils, Hirschfield, Gideon M, Hoek, B van, Holm, Kristian, Hohenester, Simon, Hov, Johannes Roksund, Imhann, Floris, Invernizzi, Pietro, Juran, Brian D, Lenzen, Henrike, Lieb, Wolfgang, Liu, Jimmy Z, Marschall, Hanns-Ulrich, Marzioni, Marco, Melum, Espen, Milkiewicz, Piotr, Müller, Tobias, Pares, Albert, Rupp, Christian, Rust, Christian, Sandford, Richard N, Schramm, Christoph, Schreiber, Stefan, Schrumpf, Erik, Silverberg, Mark S, Srivastava, Brijesh, Sterneck, Martina, Teufel, Andreas, Vallier, Ludovic, Verheij, Joanne, Vila, Arnau Vich, Vries, Boudewijn de, Zachou, Kalliopi, Chapman, Roger W, Manns, Michael P, Pinzani, Massimo, Rushbrook, Simon M, Lazaridis, Konstantinos N, Franke, Andre, Anderson, Carl A, Karlsen, Tom H, Ponsioen, Cyriel Y, and Weersma, Rinse K

Subjects
Genetics, Transplantation, Chronic Liver Disease and Cirrhosis, Liver Disease, Clinical Research, Rare Diseases, Digestive Diseases - (Gallbladder), Digestive Diseases, Aetiology, 2.1 Biological and endogenous factors, Oral and gastrointestinal, Adult, Cholangitis, Sclerosing, Cohort Studies, Disease Progression, Female, Humans, Kaplan-Meier Estimate, Logistic Models, Male, Middle Aged, Polymorphism, Single Nucleotide, Proportional Hazards Models, Thrombospondins, International PSC Study Group, The UK PSC Consortium, Primary sclerosing cholangitis, genetics, liver transplantation, Clinical Sciences, Paediatrics and Reproductive Medicine, Gastroenterology & Hepatology
Abstract

ObjectivePrimary sclerosing cholangitis (PSC) is a genetically complex, inflammatory bile duct disease of largely unknown aetiology often leading to liver transplantation or death. Little is known about the genetic contribution to the severity and progression of PSC. The aim of this study is to identify genetic variants associated with PSC disease progression and development of complications.DesignWe collected standardised PSC subphenotypes in a large cohort of 3402 patients with PSC. After quality control, we combined 130 422 single nucleotide polymorphisms of all patients-obtained using the Illumina immunochip-with their disease subphenotypes. Using logistic regression and Cox proportional hazards models, we identified genetic variants associated with binary and time-to-event PSC subphenotypes.ResultsWe identified genetic variant rs853974 to be associated with liver transplant-free survival (p=6.07×10-9). Kaplan-Meier survival analysis showed a 50.9% (95% CI 41.5% to 59.5%) transplant-free survival for homozygous AA allele carriers of rs853974 compared with 72.8% (95% CI 69.6% to 75.7%) for GG carriers at 10 years after PSC diagnosis. For the candidate gene in the region, RSPO3, we demonstrated expression in key liver-resident effector cells, such as human and murine cholangiocytes and human hepatic stellate cells.ConclusionWe present a large international PSC cohort, and report genetic loci associated with PSC disease progression. For liver transplant-free survival, we identified a genome-wide significant signal and demonstrated expression of the candidate gene RSPO3 in key liver-resident effector cells. This warrants further assessments of the role of this potential key PSC modifier gene.

Published
2018

8. “They consider themselves very different”

Author

Vries, Lotje de and Schomerus, Mareike

Abstract

This article unpacks the different trajectories of a once-unified Zande people through a focus on their respective positions in the nation-states of South Sudan and the Central African Republic (CAR). While the Zande people live at the margins of their states in both countries, South Sudan’s Azande are numerous enough to carry political clout. More importantly, South Sudan’s status as a newly independent state made it open to opposition and contest, inviting dreams of alternative forms of governance and authority. In the CAR, the state has mostly remained an elusive dream, hardly offering inspiration for governance alternatives that build on the heroic histories of the once powerful Zande kingdoms. Drawing on recent histories, we show how cross-border experience of violence by the Lord’s Resistance Army and subsequent military intervention briefly brought the Azande together again, but ultimately made difference more visible and acute.

Published
2024
Full Text
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9. The role of the ideal of coherence between school and family in valuing cooperative practices of religious education

Author

Broer, Nico, de Muynck, Bram, Boele-de Bruin, Laura, Vries, Albert de, and de With, Fianne N.

Abstract

Children’s religious education is vital for the formation of pupils in Dutch Orthodox Protestant schools. Therefore, it seems self-evident that parents and teachers cooperate. This article presents research on parents’ and teachers’ opinions about the helpfulness of cooperative practices in religious education. A total of 1346 parents and teachers completed questionnaires developed from a previous study. This article finds that parents and teachers cherish the ideal of ‘coherence between school and family’ although differences between the respondent groups and school types occurred. Moreover, the research shows that this ideal influences the valuing of cooperative practices of religious education.

Published
2024
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11. Representing Sequence: The Influence of Timeline Axis and Directionon Causal Reasoning in Litigation Law

Author

Fox, Amy Rae, Berg, Martin van den, and Vries, Erica de

Subjects
external representation, courtroom graphics, visu-alization, spatial construal of time, sequence, events, multime-dia learning
Abstract

Can the representation of event sequence influence how jurorsremember and reason in a legal case? We addressed this ques-tion by examining the interaction between an individual’s pre-ferred spatial construal of time (SCT) for an external (visual-spatial) representation and the SCT of a courtroom graphic.One hundred fifty three undergraduates played the role of ju-rors in a fictitious civil trial. The details of a case were re-counted in a multimedia presentation featuring timelines an-imated in one of four orientations: left-right, right-left, top-bottom, and bottom-top. Participants were assessed on mea-sures of comprehension and causal reasoning. Results indi-cated effects of timeline orientation and SCT choice behav-ior on comprehension and reasoning. We discuss these resultsin terms of the role of attention in temporal-causal reasoning,and implications for the design of multimedia materials for thecourtroom.

Published
2016

12. Historische literatuur tot leven wekken bij Duits: Vakoverstijgend activerend literatuuronderwijs volgens de meervoudige benadering

Author

Vries, P. de, Ramachers, S.T.M.R., Zanden, P.J.A.C. van der, Vries, P. de, Ramachers, S.T.M.R., and Zanden, P.J.A.C. van der

Abstract

Contains fulltext : 307344.pdf (Publisher’s version ) (Open Access), Het kan een uitdaging zijn om leerlingen voor het lezen van literatuur te enthousiasmeren - zeker in een vreemde taal. Als het dan ook nog historische literatuur betreft, lijkt de afstand tussen de tekst en het referentiekader van de leerlingen bijzonder groot. Hoe sla je de brug naar de leerling?, 5 p.

Published
2024

14. The IceCube Neutrino Observatory Part I: Point Source Searches

Author

Collaboration, IceCube, Aartsen, MG, Abbasi, R, Abdou, Y, Ackermann, M, Adams, J, Aguilar, JA, Ahlers, M, Altmann, D, Auffenberg, J, Bai, X, Baker, M, Barwick, SW, Baum, V, Bay, R, Beatty, JJ, Bechet, S, Tjus, J Becker, Becker, K-H, Bell, M, Benabderrahmane, ML, BenZvi, S, Berghaus, P, Berley, D, Bernardini, E, Bernhard, A, Bertrand, D, Besson, DZ, Binder, G, Bindig, D, Bissok, M, Blaufuss, E, Blumenthal, J, Boersma, DJ, Bohaichuk, S, Bohm, C, Bose, D, Böser, S, Botner, O, Brayeur, L, Bretz, H-P, Brown, AM, Bruijn, R, Brunner, J, Carson, M, Casey, J, Casier, M, Chirkin, D, Christov, A, Christy, B, Clark, K, Clevermann, F, Coenders, S, Cohen, S, Cowen, DF, Silva, AH Cruz, Danninger, M, Daughhetee, J, Davis, JC, Clercq, C De, Ridder, S De, Desiati, P, Vries, KD de, With, M de, DeYoung, T, Díaz-Vélez, JC, Dunkman, M, Eagan, R, Eberhardt, B, Eisch, J, Ellsworth, RW, Euler, S, Evenson, PA, Fadiran, O, Fazely, AR, Fedynitch, A, Feintzeig, J, Feusels, T, Filimonov, K, Finley, C, Fischer-Wasels, T, Flis, S, Franckowiak, A, Frantzen, K, Fuchs, T, Gaisser, TK, Gallagher, J, Gerhardt, L, Gladstone, L, Glüsenkamp, T, Goldschmidt, A, Golup, G, Gonzalez, JG, Goodman, JA, Góra, D, Grandmont, DT, Grant, D, Groß, A, Ha, C, and Ismail, A Haj

Subjects
astro-ph.HE
Abstract

Papers on point source searches submitted to the 33nd International CosmicRay Conference (Rio de Janeiro 2013) by the IceCube Collaboration.

Published
2013

15. The IceCube Neutrino Observatory Part III: Cosmic Rays

Author

Collaboration, IceCube, Aartsen, MG, Abbasi, R, Abdou, Y, Ackermann, M, Adams, J, Aguilar, JA, Ahlers, M, Altmann, D, Auffenberg, J, Bai, X, Baker, M, Barwick, SW, Baum, V, Bay, R, Beatty, JJ, Bechet, S, Tjus, J Becker, Becker, K-H, Bell, M, Benabderrahmane, ML, BenZvi, S, Berghaus, P, Berley, D, Bernardini, E, Bernhard, A, Bertrand, D, Besson, DZ, Binder, G, Bindig, D, Bissok, M, Blaufuss, E, Blumenthal, J, Boersma, DJ, Bohaichuk, S, Bohm, C, Bose, D, Böser, S, Botner, O, Brayeur, L, Bretz, H-P, Brown, AM, Bruijn, R, Brunner, J, Carson, M, Casey, J, Casier, M, Chirkin, D, Christov, A, Christy, B, Clark, K, Clevermann, F, Coenders, S, Cohen, S, Cowen, DF, Silva, AH Cruz, Danninger, M, Daughhetee, J, Davis, JC, Clercq, C De, Ridder, S De, Desiati, P, Vries, KD de, With, M de, DeYoung, T, Díaz-Vélez, JC, Dunkman, M, Eagan, R, Eberhardt, B, Eisch, J, Ellsworth, RW, Euler, S, Evenson, PA, Fadiran, O, Fazely, AR, Fedynitch, A, Feintzeig, J, Feusels, T, Filimonov, K, Finley, C, Fischer-Wasels, T, Flis, S, Franckowiak, A, Frantzen, K, Fuchs, T, Gaisser, TK, Gallagher, J, Gerhardt, L, Gladstone, L, Glüsenkamp, T, Goldschmidt, A, Golup, G, Gonzalez, JG, Goodman, JA, Góra, D, Grandmont, DT, Grant, D, Groß, A, Ha, C, and Ismail, A Haj

Subjects
astro-ph.HE
Abstract

Papers on cosmic rays submitted to the 33nd International Cosmic RayConference (Rio de Janeiro 2013) by the IceCube Collaboration.

Published
2013

16. The IceCube Neutrino Observatory Part IV: Searches for Dark Matter and Exotic Particles

Author

Collaboration, IceCube, Aartsen, MG, Abbasi, R, Abdou, Y, Ackermann, M, Adams, J, Aguilar, JA, Ahlers, M, Altmann, D, Auffenberg, J, Bai, X, Baker, M, Barwick, SW, Baum, V, Bay, R, Beatty, JJ, Bechet, S, Tjus, J Becker, Becker, K-H, Bell, M, Benabderrahmane, ML, BenZvi, S, Berghaus, P, Berley, D, Bernardini, E, Bernhard, A, Bertrand, D, Besson, DZ, Binder, G, Bindig, D, Bissok, M, Blaufuss, E, Blumenthal, J, Boersma, DJ, Bohaichuk, S, Bohm, C, Bose, D, Böser, S, Botner, O, Brayeur, L, Bretz, H-P, Brown, AM, Bruijn, R, Brunner, J, Carson, M, Casey, J, Casier, M, Chirkin, D, Christov, A, Christy, B, Clark, K, Clevermann, F, Coenders, S, Cohen, S, Cowen, DF, Silva, AH Cruz, Danninger, M, Daughhetee, J, Davis, JC, Clercq, C De, Ridder, S De, Desiati, P, Vries, KD de, With, M de, DeYoung, T, Díaz-Vélez, JC, Dunkman, M, Eagan, R, Eberhardt, B, Eisch, J, Ellsworth, RW, Euler, S, Evenson, PA, Fadiran, O, Fazely, AR, Fedynitch, A, Feintzeig, J, Feusels, T, Filimonov, K, Finley, C, Fischer-Wasels, T, Flis, S, Franckowiak, A, Frantzen, K, Fuchs, T, Gaisser, TK, Gallagher, J, Gerhardt, L, Gladstone, L, Glüsenkamp, T, Goldschmidt, A, Golup, G, Gonzalez, JG, Goodman, JA, Góra, D, Grandmont, DT, Grant, D, Groß, A, Ha, C, and Ismail, A Haj

Subjects
astro-ph.HE
Abstract

Papers on searches for Dark Matter and exotic particles submitted to the 33ndInternational Cosmic Ray Conference (Rio de Janeiro 2013) by the IceCubeCollaboration.

Published
2013

17. The IceCube Neutrino Observatory Part VI: Ice Properties, Reconstruction and Future Developments

Author

Collaboration, IceCube, Aartsen, MG, Abbasi, R, Abdou, Y, Ackermann, M, Adams, J, Aguilar, JA, Ahlers, M, Altmann, D, Auffenberg, J, Bai, X, Baker, M, Barwick, SW, Baum, V, Bay, R, Beatty, JJ, Bechet, S, Tjus, J Becker, Becker, K-H, Bell, M, Benabderrahmane, ML, BenZvi, S, Berghaus, P, Berley, D, Bernardini, E, Bernhard, A, Bertrand, D, Besson, DZ, Binder, G, Bindig, D, Bissok, M, Blaufuss, E, Blumenthal, J, Boersma, DJ, Bohaichuk, S, Bohm, C, Bose, D, Böser, S, Botner, O, Brayeur, L, Bretz, H-P, Brown, AM, Bruijn, R, Brunner, J, Carson, M, Casey, J, Casier, M, Chirkin, D, Christov, A, Christy, B, Clark, K, Clevermann, F, Coenders, S, Cohen, S, Cowen, DF, Silva, AH Cruz, Danninger, M, Daughhetee, J, Davis, JC, Clercq, C De, Ridder, S De, Desiati, P, Vries, KD de, With, M de, DeYoung, T, Díaz-Vélez, JC, Dunkman, M, Eagan, R, Eberhardt, B, Eisch, J, Ellsworth, RW, Euler, S, Evenson, PA, Fadiran, O, Fazely, AR, Fedynitch, A, Feintzeig, J, Feusels, T, Filimonov, K, Finley, C, Fischer-Wasels, T, Flis, S, Franckowiak, A, Frantzen, K, Fuchs, T, Gaisser, TK, Gallagher, J, Gerhardt, L, Gladstone, L, Glüsenkamp, T, Goldschmidt, A, Golup, G, Gonzalez, JG, Goodman, JA, Góra, D, Grandmont, DT, Grant, D, Groß, A, Ha, C, and Ismail, A Haj

Subjects
astro-ph.HE
Abstract

Papers on ice properties, reconstruction and future developments submitted tothe 33nd International Cosmic Ray Conference (Rio de Janeiro 2013) by theIceCube Collaboration.

Published
2013

18. The IceCube Neutrino Observatory Part II: Atmospheric and Diffuse UHE Neutrino Searches of All Flavors

Author

Collaboration, IceCube, Aartsen, MG, Abbasi, R, Abdou, Y, Ackermann, M, Adams, J, Aguilar, JA, Ahlers, M, Altmann, D, Auffenberg, J, Bai, X, Baker, M, Barwick, SW, Baum, V, Bay, R, Beatty, JJ, Bechet, S, Tjus, J Becker, Becker, K-H, Bell, M, Benabderrahmane, ML, BenZvi, S, Berghaus, P, Berley, D, Bernardini, E, Bernhard, A, Bertrand, D, Besson, DZ, Binder, G, Bindig, D, Bissok, M, Blaufuss, E, Blumenthal, J, Boersma, DJ, Bohaichuk, S, Bohm, C, Bose, D, Böser, S, Botner, O, Brayeur, L, Bretz, H-P, Brown, AM, Bruijn, R, Brunner, J, Carson, M, Casey, J, Casier, M, Chirkin, D, Christov, A, Christy, B, Clark, K, Clevermann, F, Coenders, S, Cohen, S, Cowen, DF, Silva, AH Cruz, Danninger, M, Daughhetee, J, Davis, JC, Clercq, C De, Ridder, S De, Desiati, P, Vries, KD de, With, M de, DeYoung, T, Díaz-Vélez, JC, Dunkman, M, Eagan, R, Eberhardt, B, Eisch, J, Ellsworth, RW, Euler, S, Evenson, PA, Fadiran, O, Fazely, AR, Fedynitch, A, Feintzeig, J, Feusels, T, Filimonov, K, Finley, C, Fischer-Wasels, T, Flis, S, Franckowiak, A, Frantzen, K, Fuchs, T, Gaisser, TK, Gallagher, J, Gerhardt, L, Gladstone, L, Glüsenkamp, T, Goldschmidt, A, Golup, G, Gonzalez, JG, Goodman, JA, Góra, D, Grandmont, DT, Grant, D, Groß, A, Ha, C, and Ismail, A Haj

Subjects
astro-ph.HE
Abstract

Papers on atmospheric and diffuse UHE neutrino searches of all flavorssubmitted to the 33nd International Cosmic Ray Conference (Rio de Janeiro 2013)by the IceCube Collaboration.

Published
2013

19. The IceCube Neutrino Observatory Part V: Neutrino Oscillations and Supernova Searches

Author

Collaboration, IceCube, Aartsen, MG, Abbasi, R, Abdou, Y, Ackermann, M, Adams, J, Aguilar, JA, Ahlers, M, Altmann, D, Auffenberg, J, Bai, X, Baker, M, Barwick, SW, Baum, V, Bay, R, Beatty, JJ, Bechet, S, Tjus, J Becker, Becker, K-H, Bell, M, Benabderrahmane, ML, BenZvi, S, Berghaus, P, Berley, D, Bernardini, E, Bernhard, A, Bertrand, D, Besson, DZ, Binder, G, Bindig, D, Bissok, M, Blaufuss, E, Blumenthal, J, Boersma, DJ, Bohaichuk, S, Bohm, C, Bose, D, Böser, S, Botner, O, Brayeur, L, Bretz, H-P, Brown, AM, Bruijn, R, Brunner, J, Carson, M, Casey, J, Casier, M, Chirkin, D, Christov, A, Christy, B, Clark, K, Clevermann, F, Coenders, S, Cohen, S, Cowen, DF, Silva, AH Cruz, Danninger, M, Daughhetee, J, Davis, JC, Clercq, C De, Ridder, S De, Desiati, P, Vries, KD de, With, M de, DeYoung, T, Díaz-Vélez, JC, Dunkman, M, Eagan, R, Eberhardt, B, Eisch, J, Ellsworth, RW, Euler, S, Evenson, PA, Fadiran, O, Fazely, AR, Fedynitch, A, Feintzeig, J, Feusels, T, Filimonov, K, Finley, C, Fischer-Wasels, T, Flis, S, Franckowiak, A, Frantzen, K, Fuchs, T, Gaisser, TK, Gallagher, J, Gerhardt, L, Gladstone, L, Glüsenkamp, T, Goldschmidt, A, Golup, G, Gonzalez, JG, Goodman, JA, Góra, D, Grandmont, DT, Grant, D, Groß, A, Ha, C, and Ismail, A Haj

Subjects
astro-ph.HE
Abstract

Papers on neutrino oscillation and supernova searches submitted to the 33ndInternational Cosmic Ray Conference (Rio de Janeiro 2013) by the IceCubeCollaboration.

Published
2013

21. Deep Underground Science and Engineering Laboratory - Preliminary Design Report

Author

Lesko, Kevin T, Acheson, Steven, Alonso, Jose, Bauer, Paul, Chan, Yuen-Dat, Chinowsky, William, Dangermond, Steve, Detwiler, Jason A, Vries, Syd De, DiGennaro, Richard, Exter, Elizabeth, Fernandez, Felix B, Freer, Elizabeth L, Gilchriese, Murdock GD, Goldschmidt, Azriel, Grammann, Ben, Griffing, William, Harlan, Bill, Haxton, Wick C, Headley, Michael, Heise, Jaret, Hladysz, Zbigniew, Jacobs, Dianna, Johnson, Michael, Kadel, Richard, Kaufman, Robert, King, Greg, Lanou, Robert, Lemut, Alberto, Ligeti, Zoltan, Marks, Steve, Martin, Ryan D, Matthesen, John, Matthew, Brendan, Matthews, Warren, McConnell, Randall, McElroy, William, Meyer, Deborah, Norris, Margaret, Plate, David, Robinson, Kem E, Roggenthen, William, Salve, Rohit, Sayler, Ben, Scheetz, John, Tarpinian, Jim, Taylor, David, Vardiman, David, Wheeler, Ron, Willhite, Joshua, and Yeck, James

Subjects
hep-ex, nucl-ex, physics.geo-ph
Abstract

The DUSEL Project has produced the Preliminary Design of the Deep UndergroundScience and Engineering Laboratory (DUSEL) at the rehabilitated formerHomestake mine in South Dakota. The Facility design calls for, on the surface,two new buildings - one a visitor and education center, the other an experimentassembly hall - and multiple repurposed existing buildings. To supportunderground research activities, the design includes two laboratory modules andadditional spaces at a level 4,850 feet underground for physics, biology,engineering, and Earth science experiments. On the same level, the designincludes a Department of Energy-shepherded Large Cavity supporting the LongBaseline Neutrino Experiment. At the 7,400-feet level, the design incorporatesone laboratory module and additional spaces for physics and Earth scienceefforts. With input from some 25 science and engineering collaborations, theProject has designed critical experimental space and infrastructure needs,including space for a suite of multidisciplinary experiments in a laboratorywhose projected life span is at least 30 years. From these experiments, acritical suite of experiments is outlined, whose construction will be fundedalong with the facility. The Facility design permits expansion and evolution,as may be driven by future science requirements, and enables participation byother agencies. The design leverages South Dakota's substantial investment infacility infrastructure, risk retirement, and operation of its SanfordLaboratory at Homestake. The Project is planning education and outreachprograms, and has initiated efforts to establish regional partnerships withunderserved populations - regional American Indian and rural populations.

Published
2011

22. Special report on emissions scenarios

Author

Nakicenovic, N., Alcamo, J., Davis, G., Vries, B. de, Fenhann, J., Gaffin, S., Gregory, K., Grubler, A., Jung, T.Y., Kram, T., Rovere, E.L. La, Michaelis, L., Mori, S., Morita, T., Pepper, W., Pitcher, H., Price, L., Riahi, K., Roehrl, A., Rogner, H-H., Sankovski, A., Schlesinger, M., Shukla, P., Smith, S., Swart, R., Rooijen, S. van, Victor, N., and Zhou, D.

Subjects
Emission Scenarios
Published
2000

23. A genotype-first approach identifies an intellectual disability-overweight syndrome caused by PHIP haploinsufficiency

Author

Jansen, Sandra, Hoischen, Alexander, Coe, Bradley P., Carvill, Gemma L., Van Esch, Hilde, Bosch, Daniëlle G. M., Andersen, Ulla A., Baker, Carl, Bauters, Marijke, Bernier, Raphael A., van Bon, Bregje W., Claahsen-van der Grinten, Hedi L., Gecz, Jozef, Gilissen, Christian, Grillo, Lucia, Hackett, Anna, Kleefstra, Tjitske, Koolen, David, Kvarnung, Malin, Larsen, Martin J., Marcelis, Carlo, McKenzie, Fiona, Monin, Marie-Lorraine, Nava, Caroline, Schuurs-Hoeijmakers, Janneke H., Pfundt, Rolph, Steehouwer, Marloes, Stevens, Servi J. C., Stumpel, Connie T., Vansenne, Fleur, Vinci, Mirella, van de Vorst, Maartje, Vries, Petra de, Witherspoon, Kali, Veltman, Joris A., Brunner, Han G., Mefford, Heather C., Romano, Corrado, Vissers, Lisenka E. L. M., Eichler, Evan E., and de Vries, Bert B. A.

Published
2018
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26. Exchange on subject pedagogy during lesson study in initial teacher education

Author

Bakker, Carien, Vries, Siebrich de, and de Glopper, Kees

Abstract

Purpose: This exploratory study investigates the extent to which lesson study (LS) in initial teacher education (ITE) teams address subject-pedagogical aspects during their conversations and what subject-pedagogical aspects are addressed. Design/methodology/approach: The two-case design of the study – one LS team in ITE comprised of an ST and experienced teachers and one comprised of an ST and novice teachers – is aimed to discover similarities and variations in their focus of attention. Findings: The conversations of both LS teams were to a large degree about subject-pedagogical aspects. Both teams paid relatively less attention to discussing the themes “subject matter” and “learning objectives” and more to “pupils” learning and “teacher activities.” Concerning the theme of “pupils” learning, the LS team with experienced teachers focused more than the novice LS team on discussing the aspects “pupils” initial situation and “expected learning behavior.” The novice LS team focused more than the experienced team on discussing their observations of individual pupils' thinking. Originality/value: The results indicate that LS in ITE with a mix of ST and experienced teachers can facilitate exchange on subject-pedagogical aspects of the research lesson. This may help develop and deepen the subject-pedagogical knowledge, views and routines of STs. The differences found between the two LS teams provide starting points for differentiation in the support of LS teams in ITE. Follow-up research could focus on the questions of whether and how LS teams in ITE bring more coherence to their attention for subject-pedagogical aspects of the lesson.

Published
2023
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27. Circulating tumour cells to drive the use of neoadjuvant chemotherapy in patients with muscle-invasive bladder cancer

Author

Beije, N., Kruijff, I.E. de, Jong, J.J de, Klaver, S.O., Vries, P. de, Jacobs, R.A.L., Somford, D.M., Slaa, E. Te, Heijden, A.G. van der, Witjes, J.A., Fossion, L., Boevé, E.R., Hoeven, J. van der, Melick, H.H.E. van, Wijburg, C.J., Bickerstaffe, H., Martens, J.W.M., Wit, R. de, Kraan, J., Sleijfer, S., Boormans, J.L., Medical Oncology, and Urology

Subjects
Male, Cancer Research, Oncology, Urinary Bladder Neoplasms, SDG 3 - Good Health and Well-being, Recurrence, Muscles, Urological cancers Radboud Institute for Molecular Life Sciences [Radboudumc 15], Humans, Female, Neoplastic Cells, Circulating, Neoadjuvant Therapy, Aged
Abstract

Contains fulltext : 248253.pdf (Publisher’s version ) (Open Access) BACKGROUND: Guidelines recommend neoadjuvant chemotherapy (NAC) for the treatment of nonmetastatic muscle-invasive bladder cancer (MIBC). NAC is, however, underutilized in practice because of its associated limited overall survival (OS) benefit and significant treatment-related toxicity. We hypothesized that the absence of circulating tumour cells (CTCs) identifies MIBC patients with such a favourable prognosis that NAC may be withheld. PATIENTS AND METHODS: The CirGuidance study was an open-label, multicentre trial that included patients with clinical stage T2-T4aN0-N1M0 MIBC, scheduled for radical cystectomy. CTC-negative patients (no CTCs detectable using the CELLSEARCH system) underwent radical surgery without NAC; CTC-positive patients (≥1 detectable CTCs) were advised to receive NAC, followed by radical surgery. The primary endpoint was the 2-year OS in the CTC-negative group with a prespecified criterion for trial success of ≥75% (95% confidence interval (CI) ±5%). RESULTS: A total of 273 patients were enrolled. Median age was 69 years; median follow-up was 36 months. The primary endpoint of 2-year OS in the CTC-negative group was 69.5% (N = 203; 95% CI 62.6%-75.5%). Two-year OS was 58.2% in the CTC-positive group (N = 70; 95% CI 45.5%-68.9%). CTC-positive patients had a higher rate of cancer-related mortality [hazard ratio (HR) 1.61, 95% CI 1.05-2.45, P = 0.03] and disease relapse (HR 1.87, 95% CI 1.28-2.73, P = 0.001) than CTC-negative patients. Explorative analyses suggested that CTC-positive patients who had received NAC (n = 22) survived longer than CTC-positive patients who had not (n = 48). CONCLUSION: The absence of CTCs in MIBC patients was associated with improved cancer-related mortality and a lower risk of disease relapse after cystectomy; however, their absence alone does not justify to withhold NAC. Exploratory analyses suggested that CTC-positive MIBC patients might derive more benefit from NAC. TRIAL REGISTRATION: Netherlands Trial Register NL3954; https://www.trialregister.nl/trial/3954.

Published
2022

28. Terrorisme in Nederland herkennen via Machine Learning

Author

Vries, P. de and Vries, P. de

Abstract

NLDA HDV Eindstudie, Deze thesis beoordeelt de bruikbaarheid van Machine Learning om de dreiging van een terroristische aanslag in Nederland te herkennen. Hiertoe worden verschillende beschikbare Machine Learning toepassingen getoetst aan een eisenpakket dat aangeeft waaraan een bruikbare Machine Learning toepassing moet voldoen. Uit de confrontatie tussen het eisenpakket en de beschikbare Machine Learning toepassingen volgt de conclusie dat Machine Learning niet bruikbaar is om de dreiging van een terroristische aanslag te herkennen in Nederland. Hoewel Machine Learning zeker de capaciteit heeft om te leren uit grote hoeveelheden data, berust de leerprestatie op de omvang van de aangeboden data. De beschikbare Machine Learning toepassingen leren van veel aangeboden gegevens. Deze toepassingen zijn daardoor in meer of mindere mate in staat om relevante terroristische grootheden te voorspellen. Juist het gelukkige gebrek aan terroristische aanslagen in Nederland, leidt ertoe dat er voor Nederland weinig data beschikbaar is om uit te leren. Hierdoor draagt Machine Learning niet bij aan effectieve en efficiënte terrorismebestrijding. Ook blijft het arbitrair of de Machine Learning toepassingen leren uit de werkelijke ‘oorzaken’ van terrorisme. Dit maakt Machine Learning vanuit validiteit ongeschikt voor de Nederlandse wet. In de literatuur is veel aandacht besteed aan welke factoren leiden tot terrorisme, maar consensus ontbreekt. Beschouwing van meerdere Machine Learning toepassing, toont aan dat de relevantie van deze factoren afhankelijk is van de geografische locatie waar je terrorisme onderzoekt. Om kennis over terrorisme in Nederland te vergroten en een grotere dataset op te bouwen om Machine Learning toe te passen moeten ook intenties of pogingen van terrorisme geregistreerd worden.

Published
2022

29. How to implement nature-based interventions in hospitals, long-term care facilities for elderly, and rehabilitation centers: A scoping review.

Author

Steensma, Rosanne, van den Bogerd, Nicole, Dijkstra, Karin, Janssen-Heijnen, Maryska, Krabbendam, Lydia, Vries, Ralph de, and Maas, Jolanda

Subjects
REHABILITATION centers, ELDER care, WEATHER, WELL-being, HOSPITALS, LONG-term care facilities
Abstract

Healthcare settings are increasingly adopting nature-based interventions (NBIs) to support users' health and well-being, but these interventions are often underutilized. To get a grip on utilization problems, insight into factors that affect use and uptake of NBIs in routine care is needed. This scoping review aimed to provide an overview of factors that facilitate or impede successful implementation of NBIs in hospitals, long-term care facilities for the elderly (LTCF), and rehabilitation centers. Systematic searches were conducted across various databases to identify studies that collected qualitative and/or quantitative data on the implementation of NBIs in healthcare settings. Findings were classified into the five domains of the Consolidated Framework for Implementation Research. A total of 57 articles were included in the review. The articles provide detailed insight into facilitating and impeding implementation factors related to the intervention (e.g., awareness, adaptability, type of natural elements, accessibility, safety, weather conditions, comfort, privacy, supportive design factors, activities). Other found factors related to the inner setting (e.g., culture, implementation climate) and individuals (e.g., characteristics and opportunities of stakeholders). Factors related to the outer setting (e.g., financing) and implementation process (e.g., teaming, assessing needs, planning, engaging, doing, integration in care and therapy, reflection and evaluation, maintenance) also emerged, but to a lesser extent. This review identified a broad range of factors important for the successful implementation of NBIs, which can guide implementation of future NBIs. To complement these findings, future studies should consider conducting implementation studies. [Display omitted] [ABSTRACT FROM AUTHOR]

Published
2025
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30. A Lifetime of Events: Age and Gender Variations in the Life Story.

Author

Vries, Brian de and Watt, David

Abstract

Adopted a structural perspective in examining life events in the context of an individual's life story. Ten men and 10 women at each of 3 age groups identified personally significant life events from their past and anticipated future. Women identified more life events and reported a younger age corresponding to their first event than men. Discusses other findings. (KW)

Published
1996

31. Investigation of deuterium trapping and release in the JET divertor during the third ILW campaign using TDS

Author

JET Contributors, Likonen, J., Heinola, K., De Backer, A., Baron-Wiechec, A., Catarino, N., Jepu, I., Ayres, C. F., Coad, P., Matthews, G. F., Widdowson, A., Abduallev, S., Abhangi, M., Abreu, P., Afzal, M., Aggarwal, K. M., Ahlgren, T., Ahn, J. H., Aho-Mantila, L., Aiba, N., Airila, M., Albanese, R., Aldred, V., Alegre, D., Alessi, E., Aleynikov, P., Alfier, A., Alkseev, A., Allinson, M., Alper, B., Alves, E., Ambrosino, G., Ambrosino, R., Amicucci, L., Amosov, V., Sunden, E. Andersson, Angelone, M., Anghel, M., Angioni, C., Appel, L., Appelbee, C., Arena, P., Ariola, M., Arnichand, H., Arshad, S., Ash, A., Ashikawa, N., Aslanyan, V., Asunta, O., Auriemma, F., Austin, Y., Avotina, L., Axton, M. D., Ayres, C., Bacharis, M., Baciero, A., Baiao, D., Bailey, S., Baker, A., Balboa, I., Balden, M., Balshaw, N., Bament, R., Banks, J. W., Baranov, Y. F., Barnard, M. A., Barnes, D., Barnes, M., Barnsley, R., Wiechec, A. Baron, Orte, L. Barrera, Baruzzo, M., Basiuk, V., Bassan, M., Bastow, R., Batista, A., Batistoni, P., Baughan, R., Bauvir, B., Baylor, L., Bazylev, B., Beal, J., Beaumont, P. S., Beckers, M., Beckett, B., Becoulet, A., Bekris, N., Beldishevski, M., Bell, K., Belli, F., Bellinger, M., Belonohy, E., Ben Ayed, N., Benterman, N. A., Bergsaker, H., Bernardo, J., Bernert, M., Berry, M., Bertalot, L., Besliu, C., Beurskens, M., Bieg, B., Bielecki, J., Biewer, T., Bigi, M., Bilkova, P., Binda, F., Bisoffi, A., Bizarro, J. P. S., Bjorkas, C., Blackburn, J., Blackman, K., Blackman, T. R., Blanchard, P., Blatchford, P., Bobkov, V., Boboc, A., Bodnar, G., Bogar, O., Bolshakova, I., Bolzonella, T., Bonanomi, N., Bonelli, F., Boom, J., Booth, J., Borba, D., Borodin, D., Borodkina, I., Botrugno, A., Bottereau, C., Boulting, P., Bourdelle, C., Bowden, M., Bower, C., Bowman, C., Boyce, T., Boyd, C., Boyer, H. J., Bradshaw, J. M. A., Braic, V., Bravanec, R., Breizman, B., Bremond, S., Brennan, P. D., Breton, S., Brett, A., Brezinsek, S., Bright, M. D. J., Brix, M., Broeckx, W., Brombin, M., Broslawski, A., Brown, D. P. D., Brown, M., Bruno, E., Bucalossi, J., Buch, J., Buchanan, J., Buckley, M. A., Budny, R., Bufferand, H., Bulman, M., Bulmer, N., Bunting, P., Buratti, P., Burckhart, A., Buscarino, A., Busse, A., Butler, N. K., Bykov, I., Byrne, J., Cahyna, P., Calabro, G., Calvo, I., Camenen, Y., Camp, P., Campling, D. C., Cane, J., Cannas, B., Capel, A. J., Card, P. J., Cardinali, A., Carman, P., Carr, M., Carralero, D., Carraro, L., Carvalho, B. B., Carvalho, I., Carvalho, P., Casson, F. J., Castaldo, C., Caumont, J., Causa, F., Cavazzana, R., Cave-Ayland, K., Cavinato, M., Cecconello, M., Ceccuzzi, S., Cecil, E., Cenedese, A., Cesario, R., Challis, C. D., Chandler, M., Chandra, D., Chang, C. S., Chankin, A., Chapman, I. T., Chapman, S. C., Chernyshova, M., Chitarin, G., Ciraolo, G., Ciric, D., Citrin, J., Clairet, F., Clark, E., Clark, M., Clarkson, R., Clatworthy, D., Clements, C., Cleverly, M., Coad, J. P., Coates, P. A., Cobalt, A., Coccorese, V., Cocilovo, V., Coda, S., Coelho, R., Coenen, J. W., Coffey, I., Colas, L., Collins, S., Conka, D., Conroy, S., Conway, N., Coombs, D., Cooper, D., Cooper, S. R., Corradino, C., Corre, Y., Corrigan, G., Cortes, S., Coster, D., Couchman, A. S., Cox, M. P., Craciunescu, T., Cramp, S., Craven, R., Crisanti, F., Croci, G., Croft, D., Crombe, K., Crowe, R., Cruz, N., Cseh, G., Cufar, A., Cullen, A., Curuia, M., Czarnecka, A., Dabirikhah, H., Dalgliesh, P., Dalley, S., Dankowski, J., Darrow, D., Davies, O., Davis, W., Day, C., Day, I. E., De Bock, M., Castro, A. de, Cal, E. de la, Luna, E. de la, De Masi, G., Pablos, J. L. de, Temmerman, G., De, De Tommasi, G., Vries, P. de, Deakin, K., Deane, J., Agostini, F. Degli, Dejarnac, R., Delabie, E., Harder, N. den, Dendy, R. O., Denis, J., Denner, P., Devaux, S., Devynck, P., Di Maio, F., Di Siena, A., Di Troia, C., Dinca, P., D’Inca, R., Ding, B., Dittmar, T., Doerk, H., Doerner, R. P., Donne, T., Dorling, S. E., Dormido-Canto, S., Doswon, S., Douai, D., Doyle, P. T., Drenik, A., Drewelow, P., Drews, P., Duckworth, Ph, Dumont, R., Dumortier, P., Dunai, D., Dunne, M., Duran, I., Durodie, F., Dutta, P., Duval, B. P., Dux, R., Dylst, K., Dzysiuk, N., Edappala, P. V., Edmond, J., Edwards, A. M., Edwards, J., Eich, Th, Ekedahl, A., El-Jorf, R., Elsmore, C. G., Enachescu, M., Ericsson, G., Eriksson, F., Eriksson, J., Eriksson, L. G., Esposito, B., Esquembri, S., Esser, H. G., Esteve, D., Evans, B., Evans, G. E., Evison, G., Ewart, G. D., Fagan, D., Faitsch, M., Falie, D., Fanni, A., Fasoli, A., Faustin, J. M., Fawlk, N., Fazendeiro, L., Fedorczak, N., Felton, R. C., Fenton, K., Fernades, A., Fernandes, H., Ferreira, J., Fessey, J. A., Fevrier, O., Ficker, O., Field, A., Fietz, S., Figueiredo, A., Figueiredo, J., Fil, A., Finburg, P., Firdaouss, M., Fischer, U., Fittill, L., Fitzgerald, M., Flammini, D., Flanagan, J., Fleming, C., Flinders, K., Fonnesu, N., Fontdecaba, J. M., Formisano, A., Forsythe, L., Fortuna, L., Fortuna-Zalesna, E., Fortune, M., Foster, S., Franke, T., Franklin, T., Frasca, M., Frassinetti, L., Freisinger, M., Fresa, R., Frigione, D., Fuchs, V., Fuller, D., Futatani, S., Fyvie, J., Gal, K., Galassi, D., Galazka, K., Galdon-Quiroga, J., Gallagher, J., Gallart, D., Galvao, R., Gao, X., Gao, Y., Garcia, J., Garcia-Carrasco, A., Garcia-Munoz, M., Gardarein, J.-L., Garzotti, L., Gaudio, P., Gauthier, E., Gear, D. F., Gee, S. J., Geiger, B., Gelfusa, M., Gerasimov, S., Gervasini, G., Gethins, M., Ghani, Z., Ghate, M., Gherendi, M., Giacalone, J. C., Giacomelli, L., Gibson, C. S., Giegerich, T., Gil, C., Gil, L., Gilligan, S., Gin, D., Giovannozzi, E., Girardo, J. B., Giroud, C., Giruzzi, G., Gloeggler, S., Godwin, J., Goff, J., Gohil, P., Goloborod’ko, V., Gomes, R., Goncalves, B., Goniche, M., Goodliffe, M., Goodyear, A., Gorini, G., Gosk, M., Goulding, R., Goussarov, A., Gowland, R., Graham, B., Graham, M. E., Graves, J. P., Grazier, N., Grazier, P., Green, N. R., Greuner, H., Grierson, B., Griph, F. S., Grisolia, C., Grist, D., Groth, M., Grove, R., Grundy, C. N., Grzonka, J., Guard, D., Guerard, C., Guillemaut, C., Guirlet, R., Gurl, C., Utoh, H. H., Hackett, L. J., Hacquin, S., Hagar, A., Hager, R., Hakola, A., Halitovs, M., Hall, S. J., Cook, S. P. Hallworth, Hamlyn-Harris, C., Hammond, K., Harrington, C., Harrison, J., Harting, D., Hasenbeck, F., Hatano, Y., Hatch, D. R., Haupt, T. D. V., Hawes, J., Hawkes, N. C., Hawkins, J., Hawkins, P., Haydon, P. W., Hayter, N., Hazel, S., Heesterman, P. J. L., Hellesen, C., Hellsten, T., Helou, W., Hemming, O. N., Hender, T. C., Henderson, M., Henderson, S. S., Henriques, R., Hepple, D., Hermon, G., Hertout, P., Hidalgo, C., Highcock, E. G., Hill, M., Hillairet, J., Hillesheim, J., Hillis, D., Hizanidis, K., Hjalmarsson, A., Hobirk, J., Hodille, E., Hogben, C. H. A., Hogeweij, G. M. D., Hollingsworth, A., Hollis, S., Homfray, D. A., Horacek, J., Hornung, G., Horton, A. R., Horton, L. D., Horvath, L., Hotchin, S. P., Hough, M. R., Howarth, P. J., Hubbard, A., Huber, A., Huber, V., Huddleston, T. M., Hughes, M., Huijsmans, G. T. A., Hunter, C. L., Huynh, P., Hynes, A. M., Iglesias, D., Imazawa, N., Imbeaux, F., Imrisek, M., Incelli, M., Innocente, P., Irishkin, M., Ivanova-Stanik, I., Jachmich, S., Jacobsen, A. S., Jacquet, P., Jansons, J., Jardin, A., Jarvinen, A., Jaulmes, F., Jednorog, S., Jenkins, I., Jeong, C., Joffrin, E., Johnson, R., Johnson, T., Johnston, Jane, Joita, L., Jones, G., Jones, T. T. C., Hoshino, K. K., Kallenbach, A., Kamiya, K., Kaniewski, J., Kantor, A., Kappatou, A., Karhunen, J., Karkinsky, D., Karnowska, I., Kaufman, M., Kaveney, G., Kazakov, Y., Kazantzidis, V., Keeling, D. L., Keenan, T., Keep, J., Kempenaars, M., Kennedy, C., Kenny, D., Kent, J., Kent, O. N., Khilkevich, E., Kim, H. T., Kim, H. S., Kinch, A., King, C., King, D., King, R. F., Kinna, D. J., Kiptily, V., Kirk, A., Kirov, K., Kirschner, A., Kizane, G., Klepper, C., Klix, A., Knight, P., Knipe, S. J., Knott, S., Kobuchi, T., Koechl, F., Kocsis, G., Kodeli, I., Kogan, L., Kogut, D., Koivuranta, S., Kominis, Y., Koeppen, M., Kos, B., Koskela, T., Koslowski, H. R., Koubiti, M., Kovari, M., Kowalska-Strzeciwilk, E., Krasilnikov, A., Krasilnikov, V., Krawczyk, N., Kresina, M., Krieger, K., Krivska, A., Kruezi, U., Ksiazek, I., Kukushkin, A., Kundu, A., Kurki-Suonio, T., Kwak, S., Kwiatkowski, R., Kwon, O. J., Laguardia, L., Lahtinen, A., Laing, A., Lam, N., Lambertz, H. T., Lane, C., Lang, P. T., Lanthaler, S., Lapins, J., Lasa, A., Last, J. R., Laszynska, E., Lawless, R., Lawson, A., Lawson, K. D., Lazaros, A., Lazzaro, E., Leddy, J., Lee, S., Lefebvre, X., Leggate, H. J., Lehmann, J., Lehnen, M., Leichtle, D., Leichuer, P., Leipold, F., Lengar, I., Lennholm, M., Lerche, E., Lescinskis, A., Lesnoj, S., Letellier, E., Leyland, M., Leysen, W., Li, L., Liang, Y., Linke, J., Linsmeier, Ch, Lipschultz, B., Liu, G., Liu, Y., Lo Schiavo, V. P., Loarer, T., Loarte, A., Lobel, R. C., Lomanowski, B., Lomas, P. J., Lonnroth, J., Lopez, J. M., Lopez-Razola, J., Lorenzini, R., Losada, U., Lovell, J. J., Loving, A. B., Lowry, C., Luce, T., Lucock, R. M. A., Lukin, A., Luna, C., Lungaroni, M., Lungu, C. P., Lungu, M., Lunniss, A., Lupelli, I., Lyssoivan, A., Macdonald, N., Macheta, P., Maczewa, K., Magesh, B., Maget, P., Maggi, C., Maier, H., Mailloux, J., Makkonen, T., Makwana, R., Malaquias, A., Malizia, A., Manas, P., Manning, A., Manso, M. E., Mantica, P., Mantsinen, M., Manzanares, A., Maquet, Ph, Marandet, Y., Marcenko, N., Marchetto, C., Marchuk, O., Marinelli, M., Marinucci, M., Markovic, T., Marocco, D., Marot, L., Marren, C. A., Marshal, R., Martin, A., Martin, Y., Martin de Aguilera, A., Martinez, F. J., Martin-Solis, J. R., Martynova, Y., Maruyama, S., Masiello, A., Maslov, M., Matejcik, S., Mattei, M., Maviglia, F., Mayer, M., Mayoral, M. L., May-Smith, T., Mazon, D., Mazzotta, C., McAdams, R., McCarthy, P. J., McClements, K. G., McCormack, O., McCullen, P. A., McDonald, D., McIntosh, S., McKean, R., McKehon, J., Meadows, R. C., Meakins, A., Medina, F., Medland, M., Medley, S., Meigh, S., Meigs, A. G., Meisl, G., Meitner, S., Meneses, L., Menmuir, S., Mergia, K., Merrigan, I. R., Mertens, Ph, Meshchaninov, S., Messiaen, A., Meyer, H., Mianowski, S., Michling, R., Middleton-Gear, D., Miettunen, J., Militello, F., Militello-Asp, E., Miloshevsky, G., Mink, F., Minucci, S., Miyoshi, Y., Mlynar, J., Molina, D., Monakhov, I., Moneti, M., Mooney, R., Moradi, S., Mordijck, S., Moreira, L., Moreno, R., Moro, F., Morris, A. W., Morris, J., Moser, L., Mosher, S., Moulton, D., Murari, A., Muraro, A., Murphy, S., Asakura, N. N., Na, Y. S., Nabais, F., Naish, R., Nakano, T., Nardon, E., Naulin, V., Nave, M. F. F., Nedzelski, I., Nemtsev, G., Nespoli, F., Neto, A., Neu, R., Neverov, V. S., Newman, M., Nicholls, K. J., Nicolas, T., Nielsen, A. H., Nielsen, P., Nilsson, E., Nishijima, D., Noble, C., Nocente, M., Nodwell, D., Nordlund, K., Nordman, H., Nouailletas, R., Nunes, I., Oberkofler, M., Odupitan, T., Ogawa, M. T., O’Gorman, T., Okabayashi, M., Olney, R., Omolayo, O., O’Mullane, M., Ongena, J., Orsitto, F., Orszagh, J., Oswuigwe, B. I., Otin, R., Owen, A., Paccagnella, R., Pace, N., Pacella, D., Packer, L. W., Page, A., Pajuste, E., Palazzo, S., Pamela, S., Panja, S., Papp, P., Paprok, R., Parail, V., Park, M., Diaz, F. Parra, Parsons, M., Pasqualotto, R., Patel, A., Pathak, S., Paton, D., Patten, H., Pau, A., Pawelec, E., Soldan, C. Paz, Peackoc, A., Pearson, I. J., Pehkonen, S.-P., Peluso, E., Penot, C., Pereira, A., Pereira, R., Puglia, P. P. Pereira, Thun, C. Perez von, Peruzzo, S., Peschanyi, S., Peterka, M., Petersson, P., Petravich, G., Petre, A., Petrella, N., Petrzilka, V., Peysson, Y., Pfefferle, D., Philipps, V., Pillon, M., Pintsuk, G., Piovesan, P., Pires dos Reis, A., Piron, L., Pironti, A., Pisano, F., Pitts, R., Pizzo, F., Plyusnin, V., Pomaro, N., Pompilian, O. G., Pool, P. J., Popovichev, S., Porfiri, M. T., Porosnicu, C., Porton, M., Possnert, G., Potzel, S., Powell, T., Pozzi, J., Prajapati, V., Prakash, R., Prestopino, G., Price, D., Price, M., Price, R., Prior, P., Proudfoot, R., Pucella, G., Puglia, P., Puiatti, M. E., Pulley, D., Purahoo, K., Puetterich, Th, Rachlew, E., Rack, M., Ragona, R., Rainford, M. S. J., Rakha, A., Ramogida, G., Ranjan, S., Rapson, C. J., Rasmussen, J. J., Rathod, K., Ratta, G., Ratynskaia, S., Ravera, G., Rayner, C., Rebai, M., Reece, D., Reed, A., Refy, D., Regan, B., Regana, J., Reich, M., Reid, N., Reimold, F., Reinhart, M., Reinke, M., Reiser, D., Rendell, D., Reux, C., Reyes Cortes, S. D. A., Reynolds, S., Riccardo, V., Richardson, N., Riddle, K., Rigamonti, D., Rimini, F. G., Risner, J., Riva, M., Roach, C., Robins, R. J., Robinson, S. A., Robinson, T., Robson, D. W., Roccella, R., Rodionov, R., Rodrigues, P., Rodriguez, J., Rohde, V., Romanelli, F., Romanelli, M., Romanelli, S., Romazanov, J., Rowe, S., Rubel, M., Rubinacci, G., Rubino, G., Ruchko, L., Ruiz, M., Ruset, C., Rzadkiewicz, J., Saarelma, S., Sabot, R., Safi, E., Sagar, P., Saibene, G., Saint-Laurent, F., Salewski, M., Salmi, A., Salmon, R., Salzedas, F., Samaddar, D., Samm, U., Sandiford, D., Santa, P., Santala, M. I. K., Santos, B., Santucci, A., Sartori, F., Sartori, R., Sauter, O., Scannell, R., Schlummer, T., Schmid, K., Schmidt, V., Schmuck, S., Schneider, M., Schoepf, K., Schworer, D., Scott, S. D., Sergienko, G., Sertoli, M., Shabbir, A., Sharapov, S. E., Shaw, A., Shaw, R., Sheikh, H., Shepherd, A., Shevelev, A., Shumack, A., Sias, G., Sibbald, M., Sieglin, B., Silburn, S., Silva, A., Silva, C., Simmons, P. A., Simpson, J., Simpson-Hutchinson, J., Sinha, A., Sipila, S. K., Sips, A. C. C., Siren, P., Sirinelli, A., Sjostrand, H., Skiba, M., Skilton, R., Slabkowska, K., Slade, B., Smith, N., Smith, P. G., Smith, R., Smith, T. J., Smithies, M., Snoj, L., Soare, S., Solano, E. R., Somers, A., Sommariva, C., Sonato, P., Sopplesa, A., Sousa, J., Sozzi, C., Spagnolo, S., Spelzini, T., Spineanu, F., Stables, G., Stamatelatos, I., Stamp, M. F., Staniec, P., Stankunas, G., Stan-Sion, C., Stead, M. J., Stefanikova, E., Stepanov, I., Stephen, A. V., Stephen, M., Stevens, A., Stevens, B. D., Strachan, J., Strand, P., Strauss, H. R., Strom, P., Stubbs, G., Studholme, W., Subba, F., Summers, H. P., Svensson, J., Swiderski, L., Szabolics, T., Szawlowski, M., Szepesi, G., Suzuki, T. T., Tal, B., Tala, T., Talbot, A. R., Talebzadeh, S., Taliercio, C., Tamain, P., Tame, C., Tang, W., Tardocchi, M., Taroni, L., Taylor, D., Taylor, K. A., Tegnered, D., Telesca, G., Teplova, N., Terranova, D., Testa, D., Tholerus, E., Thomas, J., Thomas, J. D., Thomas, P., Thompson, A., Thompson, C.-A., Thompson, V. K., Thorne, L., Thornton, A., Thrysoe, A. S., Tigwell, P. A., Tipton, N., Tiseanu, I., Tojo, H., Tokitani, M., Tolias, P., Tomes, M., Tonner, P., Towndrow, M., Trimble, P., Tripsky, M., Tsalas, M., Tsavalas, P., Jun, D. Tskhakaya, Turner, I., Turner, M. M., Turnyanskiy, M., Tvalashvili, G., Tyrrell, S. G. J., Uccello, A., Ul-Abidin, Z., Uljanovs, J., Ulyatt, D., Urano, H., Uytdenhouwen, I., Vadgama, A. P., Valcarcel, D., Valentinuzzi, M., Valisa, M., Olivares, P. Vallejos, Valovic, M., Van De Mortel, M., Van Eester, D., Van Renterghem, W., Rooij, G. J. van, Varje, J., Varoutis, S., Vartanian, S., Vasava, K., Vasilopoulou, T., Vega, J., Verdoolaege, G., Verhoeven, R., Verona, C., Rinati, G. Verona, Veshchev, E., Vianello, N., Vicente, J., Viezzer, E., Villari, S., Villone, F., Vincenzi, P., Vinyar, I., Viola, B., Vitins, A., Vizvary, Z., Vlad, M., Voitsekhovitch, I., Vondracek, P., Vora, N., Vu, T., Pires de Sa, W. W., Wakeling, B., Waldon, C. W. F., Walkden, N., Walker, M., Walker, R., Walsh, M., Wang, E., Wang, N., Warder, S., Warren, R. J., Waterhouse, J., Watkins, N. W., Watts, C., Wauters, T., Weckmann, A., Weiland, J., Weisen, H., Weiszflog, M., Wellstood, C., West, A. T., Wheatley, M. R., Whetham, S., Whitehead, A. M., Whitehead, B. D., Widdowson, A. M., Wiesen, S., Wilkinson, J., Williams, J., Williams, M., Wilson, A. R., Wilson, D. J., Wilson, H. R., Wilson, J., Wischmeier, M., Withenshaw, G., Withycombe, A., Witts, D. M., Wood, D., Wood, R., Woodley, C., Wray, S., Wright, J., Wright, J. C., Wu, J., Wukitch, S., Wynn, A., Xu, T., Yadikin, D., Yanling, W., Yao, L., Yavorskij, V., Yoo, M. G., Young, C., Young, D., Young, I. D., Young, R., Zacks, J., Zagorski, R., Zaitsev, F. S., Zanino, R., Zarins, A., Zastrow, K. D., Zerbini, M., Zhang, W., Zhou, Y., Zilli, E., Zoita, V., Zoletnik, S., Zychor, I., Universidad de Sevilla. Departamento de Física Atómica, Molecular y Nuclear, Universidad de Sevilla. RNM138: Física Nuclear Aplicada, Department of Physics, and Materials Physics

Subjects
retention, Nuclear and High Energy Physics, Technology and Engineering, Materials science, Materials Science (miscellaneous), RETENTION, TILES, Thermal desorption, Trapping, Mass spectrometry, 114 Physical sciences, 01 natural sciences, 010305 fluids & plasmas, Fusion, plasma och rymdfysik, 0103 physical sciences, ddc:530, ta216, tiles, ta218, 010302 applied physics, Jet (fluid), ta114, Physics, Divertor, Fusion, Plasma and Space Physics, lcsh:TK9001-9401, Nuclear Energy and Engineering, Deuterium, 13. Climate action, lcsh:Nuclear engineering. Atomic power, Atomic physics
Abstract

Selected set of samples from JET ITER-Like Wall (JET-ILW) divertor tiles exposed in 2015-2016 has been analysed using Thermal Desorption Spectrometry (TDS). The deuterium (D) amounts obtained with TDS were compared with Nuclear Reaction Analysis (NRA). The highest amount of D was found on the top part of inner divertor which has regions with the thickest deposited layers as for divertor tiles removed in 2014. This area resides deep in the scrape-off layer and plasma configurations for the second (ILW-2, 2013-2014) and the third (ILW-3, 2015-2016) JET-ILW campaigns were similar. Agreement between TDS and NRA is good on the apron of Tile 1 and on the upper vertical region whereas on the lower vertical region of Tile 1 the NRA results are clearly smaller than the TDS results. Inner divertor Tile 3 has somewhat less D than Tiles 0 and 1, and the D amount decreases towards the lower part of the tile. The D retention at the divertor inner and outer corner regions is not symmetric as there is more D retention poloidally at the inner than at the outer divertor corner. In most cases the TDS spectra for the ILW-3 samples are different from the corresponding ILW-2 spectra because HD and D-2 release occurs at higher temperatures than from the ILW-2 samples indicating that the low energy traps have been emptied during the plasma operations and that D is either in the energetically deep traps or located deeper in the sample. For complete list of authors see http://dx.doi.org/10.1016/j.nme.2019.03.012

Published
2019
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33. Faecal Metabolomics in Paediatric Inflammatory Bowel Disease: A Systematic Review.

Author

Jagt, Jasmijn Z, Verburgt, Charlotte M, Vries, Ralph de, Boer, Nanne K H de, Benninga, Marc A, Jonge, Wouter J de, Limbergen, Johan E van, and Meij, Tim G J de

Abstract

Background and Aims Paediatric inflammatory bowel disease [IBD] is characterized by altered immunological and metabolic pathways. Metabolomics may therefore increase pathophysiological understanding and could develop into characterization of biomarkers for diagnosis and IBD treatment response. However, no uniform metabolomic profiles have been identified to date. This systematic review aimed to identify faecal metabolomic signatures in paediatric IBD vs controls, and to describe metabolites associated with disease activity and treatment response. Methods A literature search was performed in Embase, Medline, Web of Science and Cochrane Library. Studies assessing faecal metabolomics in paediatric patients < 18 years with IBD [ de novo , active, inactive] with comparative groups [IBD vs non-IBD; responders vs non-responders] were included. The quality of included studies was assessed according to the Newcastle–Ottawa Scale. Results Nineteen studies were included [540 patients with IBD, 386 controls], assessing faecal short-chain fatty acids [SCFA] [five studies], amino acids [AA] [ten studies], bile acids [BA] [eight studies] and other metabolites [nine studies] using various methodologies. Significantly increased levels of AA [particularly phenylalanine], primary BA and lower levels of secondary BA were described in paediatric IBD compared to controls. Faecal SCFA results varied across studies. Additionally, responders and non-responders to exclusive enteral nutrition and infliximab showed differences in baseline faecal metabolites [based on BA, AA]. Conclusions This systematic review provides evidence for distinct faecal metabolomic profiles in paediatric IBD. However, results varied across studies, possibly due to differences in study design and applied analytical techniques. Faecal metabolomics could provide more insight into host–microbial interactions in IBD, but further studies with standardized methodologies and reporting are needed. [ABSTRACT FROM AUTHOR]

Published
2022
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35. VAT and Purchases that Are Also Used by Third Parties

Author

Bijl, Jeroen and Vries, Joël de

Abstract

This article reviews and critically assesses the recent Grand Chamber judgment of the CJEU on Registers of Beneficial Ownership (RBOs) and the preceding Advocate General’s (AG’s) Opinion. Throughout this analysis, the author pinpoints at certain misconceptions and ponders on the open questions left. The article focuses on the interaction of the transparency principle with the fundamental rights of privacy and data protection. It also considers the potential impact of the judgment on ‘tax-related’ data and on fighting money laundering and tax evasion altogether. It finally, discusses the effect the judgment is expected to have on RBOs across the EU, but also on transparency in general.

Published
2023

37. Patient-reported Quality of Life in Patients with Primary Metastatic Prostate Cancer Treated with Androgen Deprivation Therapy with and Without Concurrent Radiation Therapy to the Prostate in a Prospective Randomised Clinical Trial; Data from the HORRAD Trial

Author

Boeve, L., Hulshof, M., Verhagen, P., Twisk, J.W.R., Witjes, W.P.J., Vries, P. de, Moorselaar, R.J.A. van, Andel, G. van, Vis, Andre N., Boeve, L., Hulshof, M., Verhagen, P., Twisk, J.W.R., Witjes, W.P.J., Vries, P. de, Moorselaar, R.J.A. van, Andel, G. van, and Vis, Andre N.

Abstract

Item does not contain fulltext, Background: A survival benefit was demonstrated for patients with low-volume metastatic prostate cancer (mPCa) when local radiotherapy was added to androgen deprivation therapy (ADT). Objective: To determine the effect of ADT combined with external beam radiotherapy (EBRT) to the prostate on health-related quality of life (HRQoL) of patients with primary bone mPCa. Design, setting, and participants: The HORRAD trial is a multicentre randomised controlled trial recruiting 432patients with primary bone mPCa between 2004 and 2014. Intervention: Patients were randomised to ADT with EBRT or to ADT alone. Outcome measurements and statistical analysis: Patients completed two validated HRQoL questionnaires (European Organization for Research and Treatment of Cancer [EORTC] Quality of Life Questionnaire Core Module (QLQ-C30) and EORTC Quality of Life Questionnaire Prostate Module [QLQ-PR25]) at baseline and at 3, 6, 12, and24 mo after the initiation of treatment. The effect of both treatments was evaluated based on mixed-effect models. Results and limitations: Patient characteristics and HRQoL scores at baseline were similar in both arms. At baseline, 98% of patients completed the questionnaires, compared with 58% at 24 mo. Patients reported significantly more diarrhoea (difference between the groups 10.8; 95% confidence interval [CI] 7.3-14.2), bowel symptoms (4.5; 95% CI 2.1-6.8), and urinary symptoms (11.9; 95% CI 8.9-14.8) after EBRT and ADT compared with ADT alone (all between-arm difference p < 0.001). Urinary complaints levelled at 6 mo. At 2 yr, only bowel symptom scores were significantly different (8.0; 95% CI 4.8-11.1, p <= 0.001), but 68% of patients in the radiotherapy group did not report clinically relevant worsening of their bowel symptom scores. Conclusions: Patients with bone mPCa reported temporary modest urinary and bowel symptoms after combined treatment with EBRT of the prostate and ADT compared with ADT alone. For some patients (22%), deterioration of

Published
2021

38. How teachers interpret displays of students' gaze in reading comprehension assignments

Author

Knoop-van Campen, C.A.N., Kok, E., Doornik, R. van, Vries, P. de, Immink, M., Jarodzka, H., Gog, T.A.J.M. van, Knoop-van Campen, C.A.N., Kok, E., Doornik, R. van, Vries, P. de, Immink, M., Jarodzka, H., and Gog, T.A.J.M. van

Abstract

Contains fulltext : 241632.pdf (Publisher’s version ) (Open Access), Reading comprehension is a central skill in secondary education. To be able to provide adaptive instruction, teachers need to be able to accurately estimate students' reading comprehension. However, they tend to experience difficulties doing so. Eye tracking can uncover these reading processes by visualizing what a student looked at, in what order, and for how long, in a gaze display. The question is, however, whether teachers could interpret such displays. We, therefore, examined how teachers interpret gaze displays and perceived their potential use in education to foster tailored support for reading comprehension. Sixty teachers in secondary education were presented with three static gaze displays of students performing a reading comprehension task. Teachers were asked to report how they interpreted these gaze displays and what they considered to be the promises and pitfalls of gaze displays for education. Teachers interpreted in particular reading strategies in the gaze displays quite well, and also interpreted the displays as reflecting other concepts, such as motivation and concentration. Results showed that teachers' interpretations of the gaze displays were generally consistent across teachers and that teachers discriminated well between displays of different strategies. Teachers were generally positive about potential applications in educational practice. This study provides first insights into how teachers experience the utility of gaze displays as an innovative tool to support reading instruction, which is timely as rapid technological developments already enable eye tracking through webcams on regular laptops. Thus, using gaze displays in an educational setting seems to be an increasingly feasible scenario.

Published
2021

48. Central and mixed sleep apnea related to patients treated with maxillomandibular advancement for obstructive sleep apnea: A retrospective cohort study.

Author

Ho, Jean-Pierre T.F., Zhou, Ning, Verbraecken, Johan, Vries, Nico de, and Lange, Jan de

Subjects
SLEEP apnea syndromes, COHORT analysis
Abstract

The aim of this study was to evaluate the clinical efficacy of maxillomandibular advancement (MMA) for obstructive sleep apnea (OSA) patients with a percentage of central and mixed apnea index in the total apnea−hypopnea index (CMAI%) ≧25%. Patients treated with MMA for OSA were retrospectively evaluated for baseline and postoperative patient data and polysomnographic results. The pre- and postoperative obstructive, central and mixed apnea parameters were compared. Of the included 78 patients, 21 patients (27%) presented with CMAI% ≧25% (median CMAI%, 49.1%; 35.9–63.8) prior to MMA. In 67% of these cases, MMA resulted in CMAI% <25 (median CMAI%, 6.1%; 2.1–8.9) and significantly improved the apnea−hypopnea index (AHI) (p < 0.001), the lowest oxyhemoglobin saturation (p < 0.001), central and mixed apnea index (p < 0.001), percentage of central and mixed apneas of total AHI (p = 0.004), central apnea index (p < 0.001), and mixed apnea index (p < 0.001). CMAI% ≧25% emerged in 25% of patients after MMA (median CMAI%, 49.1%; 35.9–63.8). Within the undeniable limitations of the study, it seems that the presence of CMAI% ≧25% should not be regarded as a contraindication for MMA in OSA patients. [ABSTRACT FROM AUTHOR]

Published
2022
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