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This is enhanced publication content of an article published in a peer-reviewed scientific journal. This enhanced publication content is not peer-reviewed. The publisher of the original manuscript was not involved in the preparation of this infographic abstract and has neither reviewed nor approved its content.

This is a plain language summary (PLS) of an article published in a peer-reviewed scientific journal. This PLS is not peer-reviewed. The publisher of the original manuscript was not involved in the preparation of this PLS and has neither reviewed nor approved its content.

Supplemental material, sj-docx-1-tab-10.1177_1759720X221149965 for Association between baseline cardiovascular risk and incidence rates of major adverse cardiovascular events and malignancies in patients with psoriatic arthritis and psoriasis receiving tofacitinib by Lars E. Kristensen, Bruce Strober, Denis Poddubnyy, Ying-Ying Leung, Hyejin Jo, Kenneth Kwok, Ivana Vranic, Dona L. Fleishaker, Lara Fallon, Arne Yndestad and Dafna D. Gladman in Therapeutic Advances in Musculoskeletal Disease

Rheumatoid arthritis (RA) is a chronic inflammatory disorder with poorly defined aetiology characterised by synovial inflammation with variable disease severity and drug responsiveness. To investigate the peripheral blood immune cell landscape of early, drug naive RA, we performed comprehensive clinical and molecular profiling of 267 RA patients and 52 healthy vaccine recipients for up to 18 months to establish a high quality sample biobank including plasma, serum, peripheral blood cells, urine, genomic DNA, RNA from whole blood, lymphocyte and monocyte subsets. We have performed extensive multi-omic immune phenotyping, including genomic, metabolomic, proteomic, transcriptomic and autoantibody profiling. We anticipate that these detailed clinical and molecular data will serve as a fundamental resource offering insights into immune-mediated disease pathogenesis, progression and therapeutic response, ultimately contributing to the development and application of targeted therapies for RA.

This is an infographic abstract of an article published in a peer-reviewed scientific journal. This infographic abstract is not peer-reviewed. The publisher of the original manuscript was not involved in the preparation of this infographic abstract and has neither reviewed nor approved its content.

This is a plain language summary (PLS) of an article published in a peer-reviewed scientific journal. This PLS is not peer-reviewed. The publisher of the original manuscript was not involved in the preparation of this PLS and has neither reviewed nor approved its content.

Additional file 2: Table S1. Hypersensitivity TEAEs (PT) on or after the date of subject first ADA-positive test (safety population; TP3).

The full abstract for this thesis is available in the body of the thesis, and will be available when the embargo expires.

The Rondanini Pietà (1552-1564) engages the viewer in an embodied and temporal process of perceiving the becomings of sculpted form—rough and smooth surfaces, indentations, fissures and contours—enfolded in the material and physical qualities of the marble block and its flesh-like surface. Emphasizing the process of creating the work, a multitude of chisel marks animate sculpted matter and prolong the eventual pausing of the viewer’s eyes. The materiality of the stone urges the viewer to move around to perceive the sculpture as it becomes transfigured anew through the continuous morphing of the facial and bodily features of its two figures: Christ and the Virgin. Deterring the comprehensibility of the subject matter, the enfolding of matter and form, conceptualized as the infinito, calls attention to the very rhetorical and ontological nature of the work as sculpture. Kept in private collections for several centuries, the Rondanini Pietà is an uncommissioned sculpture considered to be the last work by Michelangelo Bounarroti. To interpret this Pietà, scholars have utilized established biographical, iconographic, and chronological approaches to the artist’s oeuvre. In 1934, Charles de Tolnay published the first modern study of the work, interpreting it as a testament of the artist’s religiosity—an interpretation that dominates the scholarship. Focusing primarily on a discussion of the Rondanini Pietà, this thesis introduces a concept of the infinito and with it a theoretical framework to expose the overdetermined nature of this scholarship. Judging the work to be either finished or unfinished (finito or non-finito) scholars rehearse the Cartesian dichotomy of res extensa and res cogitans, segregating matter from form and denying sculpture its ontological quality. In order to understand what comes prior to the processes of description, interpretation and contextualization, what is at stake is to rethink how we approach sculpture as a medium that has specific physical and material characteristics that determine its rhetorical potential. Making the viewer part of how sculpture works to make temporally visible the becomings of form, the concept of the infinito challenges us to reflect upon the methodologies used in the study of sculpture produced in the period.