109 results on '"Vougiouka O"'
Search Results
2. AB0034 NLRP12 GENE VARIANTS AND AUTOINFLAMMATORY DISEASES IN A GREEK PATIENT COHORT
- Author
-
Ziaragkali, S., primary, Papatheodorou, V., additional, Karamanakos, A., additional, Vougiouka, O., additional, Sapountzi, E., additional, Germenis, A., additional, Tektonidou, M. G., additional, Sfikakis, P. P., additional, and Laskari, K., additional
- Published
- 2024
- Full Text
- View/download PDF
3. Growth and Puberty in Juvenile Dermatomyositis: A Longitudinal Cohort Study
- Author
-
Nordal, E., Pistorio, A., Rygg, M., Giancane, G., Maghnie, M., Iorgi, N. di, Flemming, K., Hofer, M., Melo-Gomes, J.A., Bica, B.E.R.G., Brunner, J., Dannecker, G., Gerloni, V., Harjacek, M., Huppertz, H.I., Pratsidou-Gertsi, P., Nielsen, S., Stanevicha, V., Cate, R. ten, Vougiouka, O., Pastore, S., Simonini, G., Ravelli, A., Martini, A., Ruperto, N., and Paediat Rheumatology Int Trials
- Subjects
Male ,Delayed puberty ,Pediatrics ,medicine.medical_specialty ,Adolescent ,Standard score ,Dermatomyositis ,Cohort Studies ,03 medical and health sciences ,Pubertal stage ,0302 clinical medicine ,Rheumatology ,medicine ,Humans ,Juvenile ,Mass index ,Longitudinal Studies ,Child ,Prospective cohort study ,Juvenile dermatomyositis ,030203 arthritis & rheumatology ,business.industry ,Puberty ,medicine.disease ,Child, Preschool ,Female ,Median body ,medicine.symptom ,business ,Follow-Up Studies - Abstract
Objective To study growth and puberty in a multinational longitudinal prospective cohort of children with juvenile dermatomyositis (DM). Methods Children from 31 countries who were ages DM in active phase were studied, and analyses of height, weight, and pubertal development were conducted in those who had follow-up visits during a 2-year period and for whom anthropometric data was available. Results A total of 196 of 275 children (71%) were included. We found a significant reduction in parent-adjusted height Z score over time in female patients (P < 0.0001) and male patients (P = 0.001), but with catch-up growth at the final study visit. Median body mass index Z score peaked at 6 months (P < 0.0001) and was still significantly above baseline at the final study visit, which was at a median of 26 months after baseline (P = 0.007), with no difference between sexes. Female patients with a disease duration >= 12 months after onset had significantly lower parent-adjusted height Z score (P = 0.002) and no 2-year catch-up growth. At the final study visit, growth failure was seen in 20 of 97 female patients (21%) and in 11 of 73 male patients (15%). Height deflection ( increment height Z score less than -0.25/year) was observed in 29 of 116 female patients (25%) and 25 of 80 male patients (31.3%). Delayed puberty was seen in 20 of 55 female patients (36.4%) and in 11 of 31 male patients (35.5%). Children in early pubertal stage at baseline had the highest risk of growth failure. Conclusion Juvenile DM in the active phase and/or its treatment has a significant impact on growth and puberty in affected children. Children with recent onset of puberty or previous growth failure have the highest risk of delayed pubertal development and further growth retardation.
- Published
- 2020
4. Emergence of Lumpy Skin Disease in Greece, 2015
- Author
-
Tasioudi, K. E., Antoniou, S. E., Iliadou, P., Sachpatzidis, A., Plevraki, E., Agianniotaki, E. I., Fouki, C., Mangana-Vougiouka, O., Chondrokouki, E., and Dile, C.
- Published
- 2016
- Full Text
- View/download PDF
5. Bovine rabies in Greece in 2013
- Author
-
Tasioudi, K. E., Korou, L. M., Iliadou, P., Agianniotaki, E. I., Kostoglou, P., Tzani, M., Anastasiadis, I., Athanasiadis, I., Doudounakis, S., and Mangana-Vougiouka, O.
- Published
- 2015
- Full Text
- View/download PDF
6. Opportunistic infections in immunosuppressed patients with juvenile idiopathic arthritis: analysis by the Pharmachild Safety Adjudication Committee
- Author
-
Giancane G1, Swart JF2, Castagnola E3, Groll AH4, Horneff G5, 6, Huppertz HI7, Lovell DJ8, Wolfs T2, Herlin T9, Dolezalova P10, Sanner H11, Susic G13, Sztajnbok F14, Maritsi D15, Constantin T16, Vargova V17, Sawhney S18, Rygg M19, K Oliveira S21, Cattalini M22, Bovis F1, Bagnasco F1, Pistorio A23, Martini A24, Wulffraat N2, Ruperto N25, Paediatric Rheumatology International Trials Organisation (PRINTO). Cuttica R, Garay SM, Brunner J, Emminger W, Appenzeller S, Len C, Saad Magalhaes C, Telcharova-Mihaylovska A, Harjacek M, Jelusic M, Estmann A, Nielsen S, Herrera Mora C, Gervais E, Koné-Paut I, Quartier P, Foeldvari I, Horneff G, Lutz T, Minden K, Tzaribachev N, Trachana M, Tsitsami E, Vougiouka O, Orban I, Harel L, Hashkes P, Uziel Y, Cimaz R, Civino A, Consolini R, D'Angelo G, De Benedetti F, Filocamo G, Fueri E, Gallizzi R, Maggio MC, Magnolia MG, Miniaci A, Montin D, Olivieri A. N., Pastore S, Rigante D, Zulian F, Rumba-Rozenfelde I, Stanevicha V, Panaviene V, Rodriguez Lozano AL, Rubio-Perez N, Vega Cornejo G, Hoppenreijs E, Kamphuis S, Flato B, Nordal EB, Abdwani R, Miraval T, Paz Gastanaga ME, Smolewska E, Ailioaie C, Cochino AV, Laday M, Lazar C, Alexeeva E, Chasnyk V, Keltsev V, Suwairi WMS, Vijatov-Djuric G, Vojinovic J, Arkachaisri T, Koskova E, Avcin T, Ally M, Van Rensburg CJ, Louw I, Lopez JA, Boteanu AL, Calvo Penades I, De Inocencio J, Mesa-Del-Castillo P, Moreno E, Remesal A, Hofer M, Gok F, Ozen S, Ramanan A, Pallotti C, Villa L., Giancane, G1, Swart, Jf2, Castagnola, E3, Groll, Ah4, Horneff, G5, Huppertz, Hi7, Lovell, Dj8, Wolfs, T2, Herlin, T9, Dolezalova, P10, Sanner, H11, Susic, G13, Sztajnbok, F14, Maritsi, D15, Constantin, T16, Vargova, V17, Sawhney, S18, Rygg, M19, K Oliveira, S21, Cattalini, M22, Bovis, F1, Bagnasco, F1, Pistorio, A23, Martini, A24, Wulffraat, N2, Ruperto, N25, Paediatric Rheumatology International Trials Organisation (PRINTO)., Cuttica R, Garay, Sm, Brunner, J, Emminger, W, Appenzeller, S, Len, C, Saad Magalhaes, C, Telcharova-Mihaylovska, A, Harjacek, M, Jelusic, M, Estmann, A, Nielsen, S, Herrera Mora, C, Gervais, E, Koné-Paut, I, Quartier, P, Foeldvari, I, Horneff, G, Lutz, T, Minden, K, Tzaribachev, N, Trachana, M, Tsitsami, E, Vougiouka, O, Orban, I, Harel, L, Hashkes, P, Uziel, Y, Cimaz, R, Civino, A, Consolini, R, D'Angelo, G, De Benedetti, F, Filocamo, G, Fueri, E, Gallizzi, R, Maggio, Mc, Magnolia, Mg, Miniaci, A, Montin, D, Olivieri, A. N., Pastore, S, Rigante, D, Zulian, F, Rumba-Rozenfelde, I, Stanevicha, V, Panaviene, V, Rodriguez Lozano, Al, Rubio-Perez, N, Vega Cornejo, G, Hoppenreijs, E, Kamphuis, S, Flato, B, Nordal, Eb, Abdwani, R, Miraval, T, Paz Gastanaga, Me, Smolewska, E, Ailioaie, C, Cochino, Av, Laday, M, Lazar, C, Alexeeva, E, Chasnyk, V, Keltsev, V, Suwairi, Wm, Vijatov-Djuric, G, Vojinovic, J, Arkachaisri, T, Koskova, E, Avcin, T, Ally, M, Van Rensburg, Cj, Louw, I, Lopez, Ja, Boteanu, Al, Calvo Penades, I, De Inocencio, J, Mesa-Del-Castillo, P, Moreno, E, Remesal, A, Hofer, M, Gok, F, Ozen, S, Ramanan, A, Pallotti, C, Villa, L., Giancane, Gabriella, Swart, Joost F, Castagnola, Elio, Groll, Andreas H, Horneff, Gerd, Huppertz, Hans-Iko, Lovell, Daniel J, Wolfs, Tom, Herlin, Troel, Dolezalova, Pavla, Sanner, Helga, Susic, Gordana, Sztajnbok, Flavio, Maritsi, Despoina, Constantin, Tama, Vargova, Veronika, Sawhney, Sujata, Rygg, Marite, K Oliveira, Sheila, Cattalini, Marco, Bovis, Francesca, Bagnasco, Francesca, Pistorio, Angela, Martini, Alberto, Wulffraat, Nico, Ruperto, Nicolino, Cuttica, Ruben, Garay, Stella Mari, Brunner, Jurgen, Emminger, Wolfgang, Appenzeller, Simone, Len, Claudio, Saad Magalhaes, Claudia, Telcharova-Mihaylovska, Albena, Harjacek, Miroslav, Jelusic, Marija, Estmann, Anne, Nielsen, Susan, Herrera Mora, Cristina, Gervais, Elisabeth, Koné-Paut, Isabelle, Quartier, Pierre, Foeldvari, Ivan, Lutz, Thoma, Minden, Kirsten, Tzaribachev, Nikolay, Trachana, Maria, Tsitsami, Elena, Vougiouka, Olga, Orban, Ilonka, Harel, Liora, Hashkes, Philip, Uziel, Yosef, Cimaz, Rolando, Civino, Adele, Consolini, Rita, D'Angelo, Gianfranco, De Benedetti, Fabrizio, Filocamo, Giovanni, Fueri, Elena, Gallizzi, Romina, Maggio, Maria Cristina, Magnolia, Maria Greca, Miniaci, Angela, Montin, Davide, Olivieri, Alma Nunzia, Pastore, Serena, Rigante, Donato, Zulian, Francesco, Rumba-Rozenfelde, Ingrida, Stanevicha, Valda, Panaviene, Violeta, Rodriguez Lozano, Ana Luisa, Rubio-Perez, Nadina, Vega Cornejo, Gabriel, Hoppenreijs, Esther, Kamphuis, Sylvia, Flato, Berit, Nordal, Ellen Berit, Abdwani, Reem, Miraval, Tatiana, Paz Gastanaga, Maria Eliana, Smolewska, Elzbieta, Ailioaie, Constantin, Cochino, Alexis-Virgil, Laday, Matilda, Lazar, Calin, Alexeeva, Ekaterina, Chasnyk, Vyacheslav, Keltsev, Vladimir, Suwairi, Wafaa Mohammed Saad, Vijatov-Djuric, Gordana, Vojinovic, Jelena, Arkachaisri, Thaschawee, Koskova, Elena, Avcin, Tadej, Ally, Mahmood, Van Rensburg, Christa Janse, Louw, Ingrid, Lopez, Jordi Anton, Boteanu, Alina Lucica, Calvo Penades, Inmaculada, De Inocencio, Jaime, Mesa-Del-Castillo, Pablo, Moreno, Estefania, Remesal, Agustin, Hofer, Michael, Gok, Faysal, Ozen, Seza, Ramanan, Athimalaipet, Pallotti, Chiara, Villa, Luca, and Pediatrics
- Subjects
Male ,lcsh:Diseases of the musculoskeletal system ,Biologic ,Paediatrics: 760 [VDP] ,Artritis infecciosa ,MedDRA ,Infants malalts ,Arthritis ,Severity of Illness Index ,Hospital patients ,Cohort Studies ,Pharmacovigilance ,0302 clinical medicine ,030212 general & internal medicine ,Registries ,Child ,Biologics ,Immunosuppressive therapy ,Infections ,Juvenile idiopathic arthritis ,Opportunistic ,biologics ,immunosuppressive therapy ,infections ,juvenile idiopathic arthritis ,opportunistic ,Barneleddgikt ,3. Good health ,Settore MED/38 - PEDIATRIA GENERALE E SPECIALISTICA ,Antirheumatic Agents ,Child, Preschool ,Cohort ,Pediatric Infectious Disease ,Female ,Infection ,Research Article ,medicine.medical_specialty ,Tuberculosis ,juvenil idiopathic arthritis ,Opportunistic Infections ,Herpes Zoster ,03 medical and health sciences ,Immunocompromised Host ,Juvenile idiopathic arthriti ,Internal medicine ,medicine ,Humans ,book ,030203 arthritis & rheumatology ,Malalts hospitalitzats ,Immunosupressió ,business.industry ,Sick children ,medicine.disease ,Rheumatology ,Arthritis, Juvenile ,Infectious arthritis ,Pediatri: 760 [VDP] ,Orthopedic surgery ,Opportunistiske infeksjoner ,book.journal ,lcsh:RC925-935 ,business ,Infeccions oportunistes ,Immunosuppression - Abstract
Background: To derive a list of opportunistic infections (OI) through the analysis of the juvenile idiopathic arthritis (JIA) patients in the Pharmachild registry by an independent Safety Adjudication Committee (SAC). Methods: The SAC (3 pediatric rheumatologists and 2 pediatric infectious disease specialists) elaborated and approved by consensus a provisional list of OI for use in JIA. Through a 5 step-procedure, all the severe and serious infections, classified as per MedDRA dictionary and retrieved in the Pharmachild registry, were evaluated by the SAC by answering six questions and adjudicated with the agreement of 3/5 specialists. A final evidence-based list of OI resulted by matching the adjudicated infections with the provisional list of OI. Results: A total of 772 infectious events in 572 eligible patients, of which 335 serious/severe/very severe non-OI and 437 OI (any intensity/severity), according to the provisional list, were retrieved. Six hundred eighty-two of 772 (88.3%) were adjudicated as infections, of them 603/682 (88.4%) as common and 119/682 (17.4%) as OI by the SAC. Matching these 119 opportunistic events with the provisional list, 106 were confirmed by the SAC as OI, and among them infections by herpes viruses were the most frequent (68%), followed by tuberculosis (27.4%). The remaining events were divided in the groups of non-OI and possible/patient and/or pathogen-related OI. Conclusions: We found a significant number of OI in JIA patients on immunosuppressive therapy. The proposed list of OI, created by consensus and validated in the Pharmachild cohort, could facilitate comparison among future pharmacovigilance studies. © The Author(s). 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
- Published
- 2020
7. THU0498 PATIENT-REPORTED TREATMENT BURDEN AND ITS IMPACT ON QUALITY OF LIFE IN JUVENILE IDIOPATHIC ARTHRITIS: RESULTS FROM THE PHARMACHILD REGISTRY
- Author
-
Alongi, A., primary, Consolaro, A., additional, Vijatov-Djuric, G., additional, Filocamo, G., additional, Vougiouka, O., additional, Olivieri, A. N., additional, Herrera Mora, C., additional, Emminger, W., additional, Ravelli, A., additional, and Ruperto, N., additional
- Published
- 2020
- Full Text
- View/download PDF
8. Incidence and clinical profile of acute rheumatic fever in Greece
- Author
-
Kafetzis, D. A., Chantzi, F.-M., Grigoriadou, G., Vougiouka, O., and Liapi, G.
- Published
- 2005
- Full Text
- View/download PDF
9. Sleep and its relationship to health-related quality of life in children and adolescents with inactive juvenile idiopathic arthritis
- Author
-
Tsipoura, G. Lazaratou, H. Damigos, D. Vougiouka, O.
- Abstract
Aim of the work: To describe and compare sleep disturbance in children and adolescents with inactive juvenile idiopathic arthritis (JIA) and to study their relation to health-related quality of life (HRQoL). Patients and methods: Fifty JIA patients and 50 controls along with their parents were studied. Sleep disturbance was assessed by the Children's Sleep Habits Questionnaire (CSHQ) and HRQoL was assessed according to the revised KINDLR questionnaire. Results: The 50 JIA children were 14 boys (28%) and 36 girls (72%); 58% children and 42% adolescent. The mean age of participants was comparable between boys (11.6 ± 2.9 years) and girls (11.4 ± 3.3 years) either in JIA (p =.76) or control (p =.56). Patients enrolled had enthesitis-related arthritis in 6(12%), RF-positive polyarthritis in 8(16%), oligoarthritis in 32(64%), systemic arthritis in 2(4%) and psoriatic arthritis in 2(4%). Patients had higher CSHQ score (45.5 ± 8.2) and a lower KINDLR (72.4 ± 16.8) compared to the control (40.4 ± 3.4 and 78.3 ± 5.4; p
- Published
- 2018
10. Kawasaki Disease after Streptococcal Pneumonia
- Author
-
Argyri, I. Soldatou, A. Grigoriadou, G. Vougiouka, O. Tsolia, M.
- Abstract
A 4.5-year-old girl presented to the emergency department with a 5-day history of high fever, fatigue, and rash. Because of pneumonia with pleural empyema and sepsis caused by Streptococcus pyogenes, she was admitted to the pediatric intensive care unit. After initial improvement and on the eighth day, she became febrile again and also developed conjunctivitis, rash, cervical lymphadenopathy, periungual desquamation, and elevated inflammatory markers. A cardiac echo revealed a limited dilatation of the left main coronary artery. Because of suspicion of secondary Kawasaki disease, she received intravenous immunoglobulin and acetylsalicylic acid. There was an immediate clinical response with improvement of all clinical manifestations and laboratory findings. During follow-up examination 1 month later, the diameter of the left main coronary artery was within normal limits. A high index of suspicion of Kawasaki disease in children is required upon development of fever and compatible signs and symptoms in patients with serious streptococcal disease. © 2018 Wolters Kluwer Health, Inc. All rights reserved.
- Published
- 2018
11. Expert consensus on dynamics of laboratory tests for diagnosis of macrophage activation syndrome complicating systemic juvenile idiopathic arthritis
- Author
-
Ravelli, A, Minoia, F, Davì, S, Horne, A, Bovis, F, Pistorio, A, Aricò, M, Avcin, T, Behrens, Em, De Benedetti, F, Filipovic, A, Grom, Aa, Henter, J-i, Ilowite, Nte, Jordan, Mb, Khubchandani, R, Kitoh, T, Lehmberg, K, Lovell, Dj, Miettunen, P, Nichols, Ke, Ozen, S, Schmid, Jp, Ramanan, Av, Russo, R, Schneider, R, Sterba, G, Uziel, Y, Wallace, C, Wouters, C, Wulffraat, N, Demirkaya, E, Brunner, Hi, Martini, A, Ruperto, N, Cron, Rq, Angioloni, S, Pallotti, C, Pesce, M, Rinaldi, M, Villa, L, Abinun, M, Aggarwal, A, Akikusa, J, Al-mayouf, Sm, Alessio, M, Anton, J, Apaz, Mt, Astigarraga, I, Ayaz, Na, Barone, P, Bica, B, Bolt, I, Breda, L, Chasnyk, V, Cimaz, R, Corona, F, Cuttica, R, D'Angelo, G, Davidsone, Z, De Cunto, C, De Inocencio, J, Eisenstein, E, Enciso, S, Espada, G, Fischbach, M, Frosch, M, Gallizzi, R, Gamir, Ml, Gao, Y-j, Griffin, T, Hashad, S, Hennon, T, Horneff, G, Huasong, Z, Huber, A, Insalaco, A, Ioseliani, M, Jelusic-drazic, M, Jeng, M, Kapovic, A, Kasapcopur, O, Kone-paut, I, De Oliveira Skf, Lattanzi, B, Lepore, L, Li, C, Lipton, Jm, Magni-manzoni, S, Maritsi, D, Mccurdy, D, Merino, R, Mulaosmanovic, V, Nielsen, S, Pal, P, Prahalad, S, Rigante, Donato, Rumba-rozenfelde, I, Magalhaes, Cs, Sanner, H, Sawhney, S, Sewairi, Wm, Shakoory, B, Shenoi, S, Clovis, As, Stanevicha, V, Stine, Kc, Susic, G, Sztajnbok, F, Takei, S, Tezer, H, Trauzeddel, R, Tsitsami, E, Unsal, E, Vougiouka, O, Weaver, Lk, Weiss, J, Weitzman, S, On Behalf Of The Pediatric Rheumatology International Trials Organization, Zletni M., The Childhood Arthritis & Rheumatology Research Alliance, The Pediatric Rheumatology Collaborative Study Group And The Histiocyte Society, Ravelli, A., Minoia, F., Davi, S., Horne, A., Bovis, F., Pistorio, A., Arico, M., Avcin, T., Behrens, E. M., De Benedetti, F., Filipovic, A., Grom, A. A., Henter, J. -I., Ilowite, N. T., Jordan, M. B., Khubchandani, R., Kitoh, T., Lehmberg, K., Lovell, D. J., Miettunen, P., Nichols, K. E., Ozen, S., Schmid, J. P., Ramanan, A. V., Russo, R., Schneider, R., Sterba, G., Uziel, Y., Wallace, C., Wouters, C., Wulffraat, N., Demirkaya, E., Brunner, H. I., Martini, A., Ruperto, N., Cron, R. Q., Angioloni, S., Pallotti, C., Pesce, M., Rinaldi, M., Villa, L., Abinun, M., Aggarwal, A., Akikusa, J., Al-Mayouf, S. M., Alessio, M., Anton, J., Apaz, M. T., Astigarraga, I., Ayaz, N. A., Barone, P., Bica, B., Bolt, I., Breda, L., Chasnyk, V., Cimaz, R., Corona, F., Cuttica, R., D'Angelo, G., Davidsone, Z., De Cunto, C., De Inocencio, J., Eisenstein, E., Enciso, S., Espada, G., Fischbach, M., Frosch, M., Gallizzi, R., Gamir, M. L., Gao, Y. -J., Griffin, T., Hashad, S., Hennon, T., Horneff, G., Huasong, Z., Huber, A., Insalaco, A., Ioseliani, M., Jelusic-Drazic, M., Jeng, M., Kapovic, A., Kasapcopur, O., Kone-Paut, I., De Oliveira, S. K. F., Lattanzi, B., Lepore, L., Li, C., Lipton, J. M., Magni-Manzoni, S., Maritsi, D., Mccurdy, D., Merino, R., Mulaosmanovic, V., Nielsen, S., Pal, P., Prahalad, S., Rigante, D., Rumba-Rozenfelde, I., Magalhaes, C. S., Sanner, H., Sawhney, S., Sewairi, W. M., Shakoory, B., Shenoi, S., Clovis, A. S., Stanevicha, V., Stine, K. C., Susic, G., Sztajnbok, F., Takei, S., Tezer, H., Trauzeddel, R., Tsitsami, E., Unsal, E., Vougiouka, O., Weaver, L. K., Weiss, J., Weitzman, S., Zletni, M., and Çocuk Sağlığı ve Hastalıkları
- Subjects
medicine.medical_specialty ,systemic juvenile idiopathic arthritis ,Epidemiology ,Immunology ,Arthritis ,Bioinformatics ,03 medical and health sciences ,0302 clinical medicine ,Rheumatology ,Internal medicine ,medicine ,Journal Article ,Immunology and Allergy ,030212 general & internal medicine ,Juvenile Idiopathic Arthritis ,Prospective cohort study ,030203 arthritis & rheumatology ,medicine.diagnostic_test ,business.industry ,Paediatric Rheumatology ,medicine.disease ,Outcomes research ,Settore MED/38 - PEDIATRIA GENERALE E SPECIALISTICA ,Macrophage activation syndrome ,Erythrocyte sedimentation rate ,Absolute neutrophil count ,sense organs ,business - Abstract
OBJECTIVE: To identify which laboratory tests that change over time are most valuable for the timely diagnosis of macrophage activation syndrome (MAS) complicating systemic juvenile idiopathic arthritis (sJIA).METHODS: A multistep process, based on a combination of expert consensus and analysis of real patient data, was conducted. A panel of experts was first asked to evaluate 115 profiles of patients with MAS, which included the values of laboratory tests at the pre-MAS visit and at MAS onset, and the change in values between the two time points. The experts were asked to choose the 5 laboratory tests in which change was most important for the diagnosis of MAS and to rank the 5 selected tests in order of importance. The relevance of change in laboratory parameters was further discussed and ranked by the same experts at a consensus conference.RESULTS: Platelet count was the most frequently selected test, followed by ferritin level, aspartate aminotransferase (AST), white cell count, neutrophil count, and fibrinogen and erythrocyte sedimentation rate. Ferritin was most frequently assigned the highest score. At the end of the process, platelet count, ferritin level and AST were the laboratory tests in which the experts found change over time to be most important.CONCLUSIONS: We identified the laboratory tests in which change over time is most valuable for the early diagnosis of MAS in sJIA. The dynamics of laboratory values during the course of MAS should be further scrutinised in a prospective study in order to establish the optimal cut-off values for their variation.
- Published
- 2016
12. Sheep poxvirus identification from clinical specimens by PCR, cell culture, immunofluorescence and agar gel immunoprecipitation assay
- Author
-
Mangana-Vougiouka, O, Markoulatos, P, Koptopoulos, G, Nomikou, K, Bakandritsos, N, and Papadopoulos, P
- Published
- 2000
- Full Text
- View/download PDF
13. Sheep poxvirus identification by PCR in cell cultures
- Author
-
Mangana-Vougiouka, O., Markoulatos, P., Koptopoulos, G., Nomikou, K., Bakandritsos, N., and Papadopoulos, O.
- Published
- 1999
- Full Text
- View/download PDF
14. Epizootiological investigation of the most important infectious equine diseases in Greece
- Author
-
K Zafiropoulou, D Ntousi, M. Patakakis, D Dilaveris, Kyriaki Nomikou, Mangana-Vougiouka O, E Orfanou, D. Panagiotatos (Δ. Παναπωτατοσ), and S Boutsini
- Subjects
medicine.medical_specialty ,Veterinary medicine ,biology ,business.industry ,Equine diseases ,Glanders ,General Medicine ,West Nile encephalitis ,Seroepidemiologic Studies ,medicine.disease ,biology.organism_classification ,Virology ,Equine viral arteritis ,Epidemiology ,biology.protein ,Medicine ,African horse sickness ,Animal Science and Zoology ,Antibody ,business - Abstract
During the period 2001 to 2008, a total of 7,872 equine sera were tested at the Centre of Veterinary Institutes of Athens. Antibodies against seven infectious diseases of equids were determined: equine infectious anaemia (EIA), African horse sickness (AHS), equine viral arteritis (EVA), West Nile encephalitis (WNE), glanders, piroplasmosis and dourine. Tests for the four viral diseases found 4.5% seropositivity for EIA, 0% for AHS, 3.3% for EVA and 4% for WNE. All sera tested for glanders antibodies were negative. Tests for piroplasmosis detected antibodies against T. equi and B. caballi in 12.9% and 1.3% of the sera, respectively. No sample tested positive for dourine. The results of this epidemiological survey provide strong evidence that Greece is free from the diseases of AHS, glanders and dourine.
- Published
- 2013
15. Performance of Birmingham Vasculitis Activity Score and disease extent index in childhood vasculitides
- Author
-
Demirkaya, E, Ozen, S, Pistorio, A, Galasso, R, Ravelli, A, Hasija, R, Baskin, E, Dressler, F, Fischbach, M, Garcìa Consuegra, J, Iagaru, N, Pasic, S, Scarpato, S, Rossum, v, Apaz, M, Barash, J, Calcagno, G, Gonzalez, B, Hoppenreijs, E, Ioseliani, M, Mazur-Zielinska, H, Vougiouka, O, Wulffraat, N, Luqmani, R, and Martini, A
- Abstract
OBJECTIVES: To evaluate the performance of the Birmingham Vasculitis Activity Score (BVAS) v3 and the Disease Extent Index (DEI) for the assessment of disease activity in 4 primary childhood (c-) systemic vasculitides. METHODS: Patients fulfilling the EULAR/PRINTO/PRES (Ankara) c-vasculitis classification criteria for Henoch-Schönlein purpura (HSP), childhood (c) polyarteritis nodosa (c-PAN), c-Wegener's granulomatosis (c-WG) and c-Takayasu arteritis (c-TA) with disease duration at the time of diagnosis ≤3 months were extracted from the PRINTO database. The performance of the BVAS and DEI were examined by assessing convergent validity, the pattern of disease involvement, and responsiveness. We also evaluated alternative unweighted scoring methods for both tools. RESULTS: The analysis set included 796 patients with 669 HSP, 80 c-PAN, 25 c-WG and 22 c-TA. The median age at diagnosis was 6.9 years (6.6-12) and median delay in making the diagnosis from the onset of signs/symptoms was 0.01 (0.003-0.027) years. A strong correlation was found between the BVAS and DEI (rs=0.78) while correlation with the physician global assessment was moderate (rs=0.48) with BVAS and poor with DEI (rs=0.25). Both the BVAS and DEI sub-scores and total scores were able to descrive the disease involvement in the 4 childhood vasculitides. Responsiveness was large (>1.5) for both tools. The performance characteristics of the BVAS and DEI with the unweighted methods were comparable. CONCLUSIONS: This study demonstrates that both the BVAS and DEI are valid tools for the assessment of the level of disease activity in a large cohort of childhood acute and chronic vasculitides.
- Published
- 2016
16. The response to the inactivated Hepatitis A vaccine in children with autoinflammatory diseases: A prospective observational controlled study
- Author
-
Maritsi, D.N. Vartzelis, G. Kossiva, L. Vougiouka, O. Garoufi, A.
- Published
- 2016
17. An epizootiological survey of sheep pox in Greece from 1982 to 1998
- Author
-
D. Panagiotatos (Δ. Παναπωτατοσ), N. Bakandritsos (Ν. Μπακανδριτσοσ), Kyriaki Nomikou, Mangana-Vougiouka O, and G. Koptopoulos
- Subjects
General Veterinary - Abstract
Η eυλογιά του προβάτου eίναι λοιμώδeς νόσημα υψηλής μeταδοτικότητας, το οποίο eκδηλώνeται σποραδικά σe ορισμένeς πeριοχές της χώρας μας τα τeλeυταία χρόνια. Πιστeύeται ότι eισάγeται στη χώρα μας από γeιτονικές χώρeς, μέσω των διασυνοριακών μeτακινήσeων ζώων και πιθανώς ανθρώπων. Στην ανακοίνωση μας αυτή παρατίθeνται eπιζωοτιολογικά στοιχeία των τeλeυταίων 17 eτών, έτσι ώστe να eίναι δυνατή η παρακολούθηση της eξέλιξης του νοσήματος και η eξαγωγή συμπeρασμάτων. Από το 1982 έως το 1986 δeν υπήρχαν κρούσματα eυλογιάς στη χώρα. Η πρώτη eστία eμφανίσθηκe στο Νομό Λέσβου το 1987, αλλά δeν eπeκτάθηκe. Το 1988 σημeιώθηκαν eστίeς στο Νομό Έβρου, όπου και πάλι το νόσημα πeριορίστηκe έγκαιρα. Το 1994 eπανeμφανίσθηκe μία μόνο eστία στο Νομό Έβρου. Από το 1995 έως το 1998 eμφανίστηκαν πολλές eστίeς στο Νομό Έβρου, καθώς και σe άλλeς πeριοχές, όπως στο Νομό Θeσσαλονίκης (1995), στους Νομούς Λάρισας, Ξάνθης, Ροδόπης, Καβάλας, Μαγνησίας και στη Λήμνο (1996). Το 1997 υπήρξαν κρούσματα eυλογιάς eκτός του Νομοΰ Eβρου, στους Νομούς Καβάλας, Μαγνησίας, Χαλκιδικής και στη Σαμοθράκη. Το 1998 οι eστίeς πeριορίστηκαν και σe αριθμό και σe έκταση και παρέμeιναν στα όρια του Νομού Έβρου.
- Published
- 2018
18. THE IMMUNE RESPONSE TO HEPATITIS A VACCINE IN CHILDREN WITH AUTOINFLAMMATORY DISORDERS
- Author
-
Maritsi, D. Vartzelis, G. Metaxa, Z. Vougiouka, O. and Spyridis, N. Diamantopoulos, S.
- Published
- 2015
19. An Infant with Purpuric Rash and Edema
- Author
-
Argyri, I. Korona, A. Mougkou, K. Vougiouka, O. Tsolia, M. Spyridis, N.
- Published
- 2015
20. Rabies in Greece; Historical perspectives in view of the current re-emergence in wild and domestic animals
- Author
-
Tsiodras, S. Korou, L.-M. Tzani, M. Tasioudi, K.E. Kalachanis, K. Mangana-Vougiouka, O. Rigakos, G. Dougas, G. Seimenis, A.M. Kontos, V.
- Abstract
Greece has been rabies free since 1987 while no human cases have been seen since 1970. The re-emergence of rabies in Northern Greece during 2012-2013 in wild and domestic animals prompted a systematic review of historical evidence of the presence of the disease in the country from ancient years till the present. Historical data is presented along with efforts to prevent disease in animals and humans especially during the high prevalent periods in the country in the mid-20th century. These efforts serve as a guide to current extensive efforts to prevent spread especially in the wild and domestic animal populations. © 2014 Elsevier Ltd.
- Published
- 2014
21. Sheep poxvirus identification from clinical specimens by PCR, cell culture, immunofluorescence and agar gel immunoprecipitation assay
- Author
-
N. Bakandritsos (Ν. Μπακανδριτσοσ), Panayotis Markoulatos, Kyriaki Nomikou, Mangana-Vougiouka O, G. Koptopoulos, and P Papadopoulos
- Subjects
Immunoprecipitation ,Orf virus ,Biopsy ,viruses ,Fluorescent Antibody Technique ,Sheep Diseases ,Poxviridae Infections ,Biology ,Immunofluorescence ,Polymerase Chain Reaction ,Sensitivity and Specificity ,Agar gel ,Antigen ,medicine ,Animals ,Molecular Biology ,Cells, Cultured ,Skin ,Sheep ,medicine.diagnostic_test ,Poxviridae ,Cell Biology ,Gold standard (test) ,Precipitin Tests ,Virology ,Molecular biology ,Cell culture ,Normal skin - Abstract
Some 40 clinical specimens of skin lesions from sheep pox suspected cases were investigated by four different diagnostic assays: PCR, virus isolation in lamb testis cell cultures, direct immunofluorescent assay (DIFA) and antigen detecting agar gel immune precipitation test (AGIPT). All the specimens were positive by PCR and virus isolation, 29 were positive by DIFA and 16 by AGIPT. Using virus isolation on cell cultures as the gold standard, the PCR sensitivity was 100%, while that of DIFA and AGIPT was 73% and 40%, respectively. Skin samples with orf lesions or normal skin biopsies were PCR-negative. Cross-reactions with orf virus were observed in three samples only in the AGIPT assay. The PCR described combines high specificity and sensitivity with speed. PCR was therefore shown to be the method of choice for sheep poxvirus diagnosis directly from clinical specimens.
- Published
- 2000
22. Detection of sheep poxvirus in skin biopsy samples by a multiplex polymerase chain reaction
- Author
-
Kyriaki Nomikou, Mangana-Vougiouka O, Panayotis Markoulatos, O. Papadopoulos, and G. Koptopoulos
- Subjects
Biopsy ,Sheep Diseases ,Poxviridae Infections ,Biology ,Polymerase Chain Reaction ,Sensitivity and Specificity ,Capripoxvirus ,law.invention ,law ,Virology ,Sheeppox virus ,Multiplex polymerase chain reaction ,medicine ,Animals ,Polymerase chain reaction ,DNA Primers ,Skin ,Sheep ,medicine.diagnostic_test ,biology.organism_classification ,DNA extraction ,Molecular biology ,DNA, Viral ,Skin biopsy ,Primer (molecular biology) - Abstract
The development of a multiplex polymerase chain reaction (PCR) method with amplification of capripoxvirus in a single-step procedure from skin biopsies using three primer pairs, two specific for capripoxvirus and one specific for alpha-tubulin is described. A sensitive multiplex PCR was achieved by optimization of parameters such as the primer concentrations, magnesium and dNTPs concentrations. False negative results that sometimes arise due to inhibitors of DNA amplification may be avoided by the inclusion in the assay of alpha-tubulin primers. The results reported on 42 skin biopsies from sheep suspected to have poxvirus infection, indicated that the assay could monitor simultaneously DNA extraction from skin biopsy samples and allow improved detection of capripoxvirus within 24 h of specimen receipt in the laboratory.
- Published
- 2000
23. Sheep poxvirus identification by PCR in cell cultures
- Author
-
Kyriaki Nomikou, G. Koptopoulos, N. Bakandritsos (Ν. Μπακανδριτσοσ), Mangana-Vougiouka O, Panayotis Markoulatos, and O. Papadopoulos
- Subjects
Male ,viruses ,Cell Culture Techniques ,Sheep Diseases ,Poxviridae Infections ,Polymerase Chain Reaction ,Sensitivity and Specificity ,Virus ,Capripoxvirus ,law.invention ,law ,Virology ,Testis ,Animals ,Poxviridae ,Polymerase chain reaction ,Sheeppox ,Sheep ,biology ,Hybridization probe ,virus diseases ,biology.organism_classification ,Open reading frame ,Chordopoxvirinae ,DNA, Viral - Abstract
A simple, rapid and specific diagnostic polymerase chain reaction (PCR) method was developed for sheep poxvirus identification. The primers used were from the sequenced genomes of the capripox viruses KS-1 and InS-1. Six different sheep pox isolates were tested against two orf (parapox) and three animal herpesviruses as controls. Material from uninfected cell cultures was also used as control. The sensitivity of the PCR was approximately equivalent with each of the two primers and for the six sheep pox isolates. All the negative control virus DNAs were negative and differed clearly from those of the sheep pox strains.
- Published
- 1999
24. THU0579 Treating To Target with Canakinumab in Patients with Active Systemic Juvenile Idiopathic Arthritis: Results from The Long-Term Extension The Phase III Pivotal Trial
- Author
-
Ruperto, N., primary, Brunner, H.I., additional, Quartier, P., additional, Constantin, T., additional, Alexeeva, E., additional, Kone-Paut, I., additional, Marzan, K., additional, Wulffraat, N., additional, Schneider, R., additional, Padeh, S., additional, Chasnyk, V., additional, Wouters, C., additional, Kuemmerle-Deschner, J.B., additional, Kallinich, T., additional, Lauwerys, B., additional, Haddad, E., additional, Nasonov, E., additional, Trachana, M., additional, Vougiouka, O., additional, Leon, K., additional, Speziale, A., additional, Lheritier, K., additional, Martini, A., additional, and Lovell, D., additional
- Published
- 2016
- Full Text
- View/download PDF
25. Treatment of autoinflammatory diseases: results from the Eurofever Registry and a literature review
- Author
-
Haar, Nienke Ter, Lachmann, Helen, Özen, Seza, Woo, Pat, Uziel, Yosef, Modesto, Consuelo, Koné Paut, Isabelle, Cantarini, Luca, Insalaco, Antonella, Neven, Bénédicte, Hofer, Michael, Rigante, Donato, Al Mayouf, Sulaiman, Touitou, Isabelle, Gallizzi, Romina, Papadopoulou Alataki, Efimia, Martino, Silvana, Kuemmerle Deschner, Jasmin, Obici, Laura, Iagaru, Nicolae, Simon, Anna, Nielsen, Susan, Martini, Alberto, Ruperto, Nicolino, Gattorno, Marco, Frenkel, Joost, Kondi, A, De Cunto, C, Espada, G, Russo, R, Amaryan, G, Boros, C, Wouters, C, de Oliveira SK, Borzutzky, A, Jelusic Drazic, M, Dolezalova, P, Herlin, T, Desjonqueres, M, Djeddi, D, Hentgen, V, Darce, M, Ioseliani, M, Berendes, R, Horneff, G, Jansson, A, Minden, K, Schwarz, T, Trauzeddel, R, Kanakoudi Tsakalidou, F, Vougiouka, O, Constantin, T, Rao, Ap, Brik, R, Harel, L, Alessio, M, Breda, L, Cimaz, R, Consolini, Rita, Fabio, G, Garozzo, R, Lepore, L, Manna, R, Meini, A, Olivieri, An, Stanevicha, V, Rusoniene, S, Hoppenreijs, E, Al Abrawi Sy, Nikishina, I, Sewairi, Wm, Susic, G, Ciznar, P, Avcin, T, Anton, J, Bou, R, Merino, R, Elorduy, Mj, Fasth, A, Aksu, G, Demirkaya, E., Ter Haar, N., Lachmann, H., Özen, S., Woo, P., Uziel, Y., Modesto, C., Koné Paut, I., Cantarini, L., Insalaco, A., Neven, B., Hofer, M., Rigante, D., Al Mayouf, S., Touitou, I., Gallizzi, R., Papadopoulou Alataki, E., Martino, S., Kuemmerle Deschner, J., Obici, L., Iagaru, N., Simon, A., Nielsen, S., Martini, A., Ruperto, N., Gattorno, M., Frenkel, J., and Olivieri, Alma Nunzia
- Subjects
Genetics and Molecular Biology (all) ,medicine.medical_specialty ,PFAPA syndrome ,Immunology ,autoinflammatory diseases ,Eurofever ,Registry ,Familial Mediterranean fever ,Disease ,Biochemistry ,General Biochemistry, Genetics and Molecular Biology ,03 medical and health sciences ,0302 clinical medicine ,Rheumatology ,autoinflammatory disease ,Internal medicine ,Acne Vulgaris ,medicine ,Immunology and Allergy ,Humans ,Registries ,030304 developmental biology ,030203 arthritis & rheumatology ,0303 health sciences ,Arthritis, Infectious ,Mevalonate kinase deficiency ,business.industry ,Hyper-IgD syndrome ,Arthritis ,Settore MED/09 - MEDICINA INTERNA ,Infectious ,Cryopyrin-associated periodic syndrome ,medicine.disease ,Cryopyrin-Associated Periodic Syndromes ,Pyoderma Gangrenosum ,3. Good health ,Familial Mediterranean Fever ,Pathogenesis and modulation of inflammation [N4i 1] ,Europe ,TNF receptor associated periodic syndrome ,Mevalonate Kinase Deficiency ,Biochemistry, Genetics and Molecular Biology (all) ,business - Abstract
Item does not contain fulltext OBJECTIVE: To evaluate the response to treatment of autoinflammatory diseases from an international registry and an up-to-date literature review. METHODS: The response to treatment was studied in a web-based registry in which clinical information on anonymised patients with autoinflammatory diseases was collected retrospectively as part of the Eurofever initiative. Participating hospitals included paediatric rheumatology centres of the Paediatric Rheumatology International Trial Organisation network and adult centres with a specific interest in autoinflammatory diseases. The following diseases were included: familial Mediterranean fever (FMF), cryopyrin-associated periodic syndromes (CAPS), tumour necrosis factor (TNF)-receptor associated periodic syndrome (TRAPS), mevalonate kinase deficiency (MKD), pyogenic arthritis pustulosis acne (PAPA) syndrome, deficiency of interleukin-1 receptor antagonist (DIRA), NLRP12-related periodic fever and periodic fever aphthosis pharyngitis adenitis (PFAPA) syndrome. Cases were independently validated by experts for each disease. A literature search regarding treatment of the abovementioned diseases was also performed using Medline and Embase. RESULTS: 22 months from the beginning of the enrolment, complete information on 496 validated patients was available. Data from the registry in combination with evidence from the literature confirmed that colchicine is the treatment of choice for FMF and IL-1 blockade for DIRA and CAPS. Corticosteroids on demand probably represent a valid therapeutic strategy for PFAPA, but also for MKD and TRAPS. Patients with poorly controlled MKD, TRAPS, PAPA or FMF may benefit from IL-1 blockade; anti-TNF treatment may represent a possible valuable alternative. CONCLUSIONS: In the absence of high-grade evidence, these results could serve as a basis for therapeutic guidelines and to identify candidate drugs for future therapeutic trials.
- Published
- 2013
26. Performance of Birmingham Vasculitis Activity Score and disease extent index in childhood vasculitides
- Author
-
Demirkaya, E, Ozen, S, Pistorio, A, Galasso, R, Ravelli, Angelo, Hasija, R, Baskin, E, Dressler, F, Fischbach, M, Garcìa Consuegra, J, Iagaru, N, Pasic, S, Scarpato, S, Van Rossum Ma, Apaz, Mt, Barash, J, Calcagno, G, Gonzalez, B, Hoppenreijs, E, Ioseliani, M, Mazur Zielinska, H, Vougiouka, O, Wulffraat, N, Luqmani, R, Martini, Alberto, Ruperto, N, and Dolezalova, P.
- Subjects
Vasculitis ,IgA Vasculitis ,Granulomatosis with Polyangiitis ,Reproducibility of Results ,Prognosis ,Severity of Illness Index ,Takayasu Arteritis ,Polyarteritis Nodosa ,Diagnosis, Differential ,Predictive Value of Tests ,Terminology as Topic ,Health Status Indicators ,Humans ,Child - Abstract
OBJECTIVES: To evaluate the performance of the Birmingham Vasculitis Activity Score (BVAS) v3 and the Disease Extent Index (DEI) for the assessment of disease activity in 4 primary childhood (c-) systemic vasculitides. METHODS: Patients fulfilling the EULAR/PRINTO/PRES (Ankara) c-vasculitis classification criteria for Henoch-Schönlein purpura (HSP), childhood (c) polyarteritis nodosa (c-PAN), c-Wegener's granulomatosis (c-WG) and c-Takayasu arteritis (c-TA) with disease duration at the time of diagnosis ≤3 months were extracted from the PRINTO database. The performance of the BVAS and DEI were examined by assessing convergent validity, the pattern of disease involvement, and responsiveness. We also evaluated alternative unweighted scoring methods for both tools. RESULTS: The analysis set included 796 patients with 669 HSP, 80 c-PAN, 25 c-WG and 22 c-TA. The median age at diagnosis was 6.9 years (6.6-12) and median delay in making the diagnosis from the onset of signs/symptoms was 0.01 (0.003-0.027) years. A strong correlation was found between the BVAS and DEI (rs=0.78) while correlation with the physician global assessment was moderate (rs=0.48) with BVAS and poor with DEI (rs=0.25). Both the BVAS and DEI sub-scores and total scores were able to descrive the disease involvement in the 4 childhood vasculitides. Responsiveness was large (>1.5) for both tools. The performance characteristics of the BVAS and DEI with the unweighted methods were comparable. CONCLUSIONS: This study demonstrates that both the BVAS and DEI are valid tools for the assessment of the level of disease activity in a large cohort of childhood acute and chronic vasculitides.
- Published
- 2011
27. A multinational study og the epidemiology, treatment and outcome of childhood arthritis (EPOCA study): Preliminary data from 6.940 patients
- Author
-
Consolaro, A, Aggarwal, A, Herlin, Troels, Vougiouka, O, Burgos-Vargas, R, Orban, I, Shafaie, N, Trachana, M, Rutkowska-Sak, L, Rumba-Rozenfelde, I, Mihaylova, D, Martini, A, and Ravelli, A
- Published
- 2011
28. The puzzling clinical spectrum and course of juvenile sarcoidosis
- Author
-
Fretzayas, A. Moustaki, M. Vougiouka, O.
- Abstract
Background: Juvenile sarcoidosis is a rare, chronic, multisystem, granulomatous disease of obscure etiology which is seen in childhood and adulthood. The disease in childhood has a course different from that in adulthood. Data sources: PubMed database was searched using terms sarcoidosis, children or childhood sarcoidosis or juvenile sarcoidosis in combination with one of the following terms: epidemiology, clinical manifestations, genetics, diagnosis, treatment, and prognosis. We also retrieved the terms such as early onset sarcoidosis and Blau syndrome. Furthermore, e-medicine and European Respiratory Society monographs for sarcoidosis were reviewed. Results: Sarcoidosis in childhood presents with two age dependent, distinct forms. In younger children it is clinically evident before the age of four years and characterized by the triad of rash, arthritis and uveitis. In their older counterparts, the juvenile late onset sarcoidosis involves several organs and its clinical appearance resembles the adult type of the disease, with the respiratory system being most frequently affected (hilar lymphadenopathy, pulmonary infiltrations). Steroid is the main agent of treatment whereas methotrexate is also used for beneficial steroid sparing effects. New, novel therapies may change the outcome of the disease especially in difficult morbid cases. Conclusions: Sarcoidosis in childhood is recognized as a systemic disease affecting various organs and having diverse clinical course depending on the age of onset. © 2011 Children's Hospital, Zhejiang University School of Medicine and Springer-Verlag Berlin Heidelberg. All rights reserved.
- Published
- 2011
29. Long term efficacy and safety of canakinumab in children with systemic juvenile idiopathic arthritis with and without fever
- Author
-
Horneff, G, primary, Ruperto, N, additional, Brunner, H, additional, Quartier, P, additional, Constantin, T, additional, Alexeeva, E, additional, Kone-Paut, I, additional, Marzan, K, additional, Wulffraat, N, additional, Schneider, R, additional, Padeh, S, additional, Chasnyk, V, additional, Wouters, C, additional, Deschner, J Kummerle, additional, Kallinich, T, additional, Lauwerys, B, additional, Haddad, E, additional, Nasonov, E, additional, Trachana, M, additional, Vougiouka, O, additional, Abrams, K, additional, Leon, K, additional, Lheritier, K, additional, Martini, A, additional, and Lovell, D, additional
- Published
- 2015
- Full Text
- View/download PDF
30. THU0505 The Immune Response to Hepatitis a Vaccine in Children with Autoinflammatory Disorders
- Author
-
Maritsi, D., primary, Vartzelis, G., additional, Metaxa, Z., additional, Vougiouka, O., additional, Spyridis, N., additional, and Diamantopoulos, S., additional
- Published
- 2015
- Full Text
- View/download PDF
31. FRI0496 Efficacy and Safety of Canakinumab in Children with Systemic Juvenile Idiopathic Arthritis with and Without Fever
- Author
-
Ruperto, N., primary, Brunner, H., additional, Quartier, P., additional, Constantin, T., additional, Alexeeva, E., additional, Kone-Paut, I., additional, Marzan, K., additional, Wulffraat, N., additional, Schneider, R., additional, Padeh, S., additional, Chasnyk, V., additional, Wouters, C., additional, Kummerle Deschner, J., additional, Kallinich, T., additional, Lauwerys, B., additional, Haddad, E., additional, Nasonov, E., additional, Trachana, M., additional, Vougiouka, O., additional, Abrams, K., additional, Leon, K., additional, Lheritier, K., additional, Martini, A., additional, and Lovell, D., additional
- Published
- 2015
- Full Text
- View/download PDF
32. S10 segment sequence analysis of some Greek bluetongue virus strains
- Author
-
Sv, Nikolakaki, Kyriaki Nomikou, Mangana-Vougiouka O, Papanastassopoulou M, Koumbati M, and Papadopoulos O
- Abstract
Sequence analyses of the non-structural protein gene NS3/NS3A of eight Greek bluetongue (BT) virus (BTV) field isolates from the 1979 and 1999-2001 epizootics provide preliminary molecular data on the epidemiology of BT in Greece. These isolates from infected sheep belonged to serotypes BTV-1, BTV-4, BTV-9 and BTV-16. Phylogenetic analysis of the NS3/NS3A gene segregated these Greek isolates of BTV into two monophyletic groups. The first group was formed by all isolates of BTV-4; all were identical in their sequences, regardless of the area and year of isolation in Greece, and clustered with strains from Tunisia and Corsica. The isolates of BTV-1, BTV-9 and BTV-16 segregated into a second monophyletic group and clustered with Asian strains, showing a high homology (97-99%). From an epidemiological point of view, these preliminary results infer that one group of isolates is Mediterranean, whilst the second appears to be of Asian origin.
- Published
- 2010
33. Bluetongue laboratory diagnosis: a ring test to evaluate serological results using a competitive ELISA kit
- Author
-
Lelli R, Di Ventura M, Mt, Mercante, Tittarelli M, Mangana-Vougiouka O, Kyriaki Nomikou, Conte A, Di Emidio B, Portanti O, Giovannucci G, Bonfini B, Zaghini M, and Caporale V
- Abstract
The occurrence of bluetongue (BT) in Italy prompted an increase in disease surveillance. Thus a competitive enzyme-linked immunosorbent assay (c-ELISA) to detect immunoglobulins to BT virus (BTV) was developed and distributed amongst 27 laboratories comprising the Italian veterinary diagnostic laboratories network to screen field sera. This ring test enabled comparison of the results and the evaluation of the reproducibility of the method. The c-ELISA developed by the National Reference Centre for Exotic Diseases (c-ELISA-IZSAM) was compared also against a commercially available c-ELISA. In addition, results obtained by the Centre of Athens Veterinary Institutions are presented.
- Published
- 2010
34. PReS-FINAL-2188: Insulin sensitivity is improved in sjia children with insulin resistance after tocilizumab treatment: results from the tender study
- Author
-
Mirjafari, H, primary, Ruperto, N, additional, Brunner, HI, additional, Zuber, Z, additional, Zulian, F, additional, Maldonado-Velázquez, MR, additional, Mantzourani, E, additional, Murray, K, additional, Roth, J, additional, Rovensky, J, additional, Vougiouka, O, additional, Wang, J, additional, Harari, O, additional, Lovell, D, additional, Martini, A, additional, and De Benedetti, F, additional
- Published
- 2013
- Full Text
- View/download PDF
35. Benign hypermobility syndrome in Greek schoolchildren
- Author
-
Vougiouka, O Moustaki, M Tsanaktsi, M
- Subjects
education - Abstract
Since the incidence of benign hypermobility syndrome is significantly high in otherwise healthy children, paediatricians should consider this benign entity when they evaluate musculoskeletal complaints in childhood.
- Published
- 2000
36. AB0252 Traps syndrome in a three generation greek family with long lasting recurrent fevers
- Author
-
Vougiouka, O., primary, Karpathios, T., additional, Konstantopoulos, H., additional, and Bakoula, C., additional
- Published
- 2013
- Full Text
- View/download PDF
37. AB1172 Safety and efficacy of a 12-MO canakinumab administration in patients with systemic juvenile idiopathic arthritis: Data from the greek national registry
- Author
-
Trachana, M., primary, Pratsidou-Gertsi, P., additional, and Vougiouka, O., additional
- Published
- 2013
- Full Text
- View/download PDF
38. Re-emergence of animal rabies in northern Greece and subsequent human exposure, October 2012 – March 2013
- Author
-
Tsiodras, S, primary, Dougas, G, additional, Baka, A, additional, Billinis, C, additional, Doudounakis, S, additional, Balaska, A, additional, Georgakopoulou, T, additional, Rigakos, G, additional, Kontos, V, additional, Tasioudi, K E, additional, Tzani, M, additional, Tsarouxa, P, additional, Iliadou, P, additional, Mangana-Vougiouka, O, additional, Iliopoulos, D, additional, Sapounas, S, additional, Efstathiou, P, additional, Tsakris, A, additional, Hadjichristodoulou, C, additional, and Kremastinou, J, additional
- Published
- 2013
- Full Text
- View/download PDF
39. Epizootiological investigation of the most important infectious equine diseases in Greece
- Author
-
MANGANA-VOUGIOUKA, O., primary, BOUTSINI, S., additional, NTOUSI, D., additional, PATAKAKIS, M., additional, ORFANOU, E., additional, ZAFIROPOULOU, K., additional, DILAVERIS, D., additional, PANAGIOTATOS, D., additional, and NOMIKOU, K., additional
- Published
- 2013
- Full Text
- View/download PDF
40. The Diversity of Juvenile Sarcoidosis Symptoms
- Author
-
Vougiouka, O., primary, Moustaki, M., additional, Nicolaidou, P., additional, and Fretzayas, Andrew, additional
- Published
- 2012
- Full Text
- View/download PDF
41. Efficacy of adalimumab in refractory juvenile idiopathic arthritis related uveitis: report of 6 cases
- Author
-
Vougiouka, O, primary, Atsali, E, additional, Panousi-Vlahou, C, additional, Azaris, S, additional, and Koidou, A, additional
- Published
- 2011
- Full Text
- View/download PDF
42. Situation actuelle de la fièvre catarrhale ovine en Grèce
- Author
-
Tsakiris, J., primary, Aronis, E., additional, Sachsamanoglou, M., additional, Petridou, P., additional, Patounis, T., additional, Iliadou, P., additional, Patakakis, M., additional, Doudounakis, S., additional, and Mangana-Vougiouka, O., additional
- Published
- 2009
- Full Text
- View/download PDF
43. The epidemiology of sheep pox in Greece from 1987 to 2007
- Author
-
MANGANA-VOUGIOUKA, O., primary, KOTTARIDI, C., additional, and NOMIKOU, K., additional
- Published
- 2008
- Full Text
- View/download PDF
44. Incidence and clinical profile of acute rheumatic fever in Greece
- Author
-
Kafetzis, D. A., primary, Chantzi, F.-M., additional, Grigoriadou, G., additional, Vougiouka, O., additional, and Liapi, G., additional
- Published
- 2004
- Full Text
- View/download PDF
45. Detection of sheep poxvirus in skin biopsy samples by a multiplex polymerase chain reaction
- Author
-
Markoulatos, P, primary, Mangana-Vougiouka, O, additional, Koptopoulos, G, additional, Nomikou, K, additional, and Papadopoulos, O, additional
- Published
- 2000
- Full Text
- View/download PDF
46. Performance of the birmingham vasculitis activity score and disease extent index in childhood vasculitides
- Author
-
Demirkaya, E., Ozen, S., Pistorio, A., Galasso, R., Ravelli, A., Hasija, R., Baskin, E., Dressler, F., Fischbach, M., Consuegra, J. G., Iagaru, N., Pasic, S., Scarpato, S., Rossum, M. A. J., Apaz, M. T., Barash, J., Calcagno, G., Gonzalez, B., Hoppenreijs, E., Ioseliani, M., Mazur-Zielinska, H., Vougiouka, O., Wulffraat, N., Luqmani, R., Martini, A., NICOLINO RUPERTO, Dolezalova, P., Amsterdam institute for Infection and Immunity, and Paediatric Infectious Diseases / Rheumatology / Immunology
- Abstract
Objectives. To evaluate the performance of the Birmingham Vasculitis Activity Score (BVAS) v3 and the Disease Extent Index (DEI) for the assessment of disease activity in 4 primary childhood (c-) systemic vasculitides. Methods. Patients fulfilling the EU-LAR/PRINTO/PRES (Ankara) c-vasculitis classification criteria for Henoch-Schonlein purpura (HSP), childhood (c) polyarteritis nodosa (c-PAN), c-Wegener's granulomatosis (c-WG) and c-Takayasu arteritis (c-TA) with disease duration at the time of diagnosis 1.5) for both tools. The performance characteristics of the BVAS and DEI with the unweighted methods were comparable. Conclusion. This study demonstrates that both the BVAS and DEI are valid tools for the assessment of the level of disease activity in a large cohort of childhood acute and chronic vasculitides
47. VP2 gene sequence analysis of some isolates of bluetongue virus recovered in the Mediterranean Basin during the 1998-2002 outbreak
- Author
-
Savini G, Ac, Potgieter, Monaco F, Mangana-Vougiouka O, Kyriaki Nomikou, Yadin H, and Caporale V
- Abstract
Since 1998, five serotypes of bluetongue virus (BTV), BTV-1, BTV-2, BTV-4, BTV-9 and BTV-16, have been reported in countries surrounding the Mediterranean Basin. Preliminary data on the sequencing analysis of the VP2-genes of BTV isolates recovered during the 1998-2002 epizootic of BT in Italy, Greece and Israel were studied. The VP2-genes of the Italian BTV-2 and BTV-9, Greek BTV-4 and BTV-9, Israeli BTV-4 and BTV-16 and South African BTV-2, BTV-4, BTV-9 and BTV-16, together with those of their corresponding South African serotype reference and vaccine strains, were cloned and the sequences of their terminal ends determined. These sequences, as well as those of all BTV VP2-gene sequences currently available on GenBank, were used to compile a phylogenetic tree to determine the probable geographic origins of the BTV incursions into Europe. The Italian isolates included in this study were from different regions, animal hosts and years (2000-2002). The results demonstrated that sequencing of the terminal end of the VP2-gene of BTV can be used for topotyping. According to the phylogenetic analysis, the Italian BTV-2 and BTV-9 isolates were stable across all species, irrespective of geographic origin and year of isolation. The sequencing data of the Italian isolates were identical to those of a BTV-2 isolate from Corsica. There was 97% homology between the Italian and Corsican BTV-2 isolates and the BTV-2 vaccine and reference isolates from South Africa. Italian BTV-9 isolates were also identical to the Greek BTV-9 isolates (99% homology). Surprisingly these BTV-9 isolates had only 67% homology with the reference BTV-9 isolate from South Africa. Conversely, BTV-9 field isolates from Australia and elsewhere in Europe had 89% homology with the Italian isolate at the nucleic acid level. Greek and Israeli BTV-4 isolates were almost identical (98% homology) and shared a 90% homology with the BTV-4 South African reference and vaccine strains. Israeli BTV-16 and South African BTV-16 reference strains were also similar. From these results, it may be concluded that Italian and Corsican BTV-2, Israeli and Greek BTV-4, and South African and Israeli BTV-16 had a common origin. The Greek BTV-9 isolate had more than 99% homology with the isolates from Italy, indicating these isolates to have had a common origin. The European BTV-9 isolates, grouped as 'eastern isolates', were more similar to the Australian isolates than to the South African reference strains.
48. Epizootiological investigation of the most important infectious equine diseases in Greece
- Author
-
Mangana-Vougiouka O, Boutsini S, Ntousi D, Patakakis M, Orfanou E, Zafiropoulou K, Dilaveris D, Panagiotatos D, and Kyriaki Nomikou
- Subjects
Greece ,Seroepidemiologic Studies ,Commerce ,Animals ,Horse Diseases ,Serologic Tests ,Horses ,Communicable Diseases - Abstract
During the period 2001 to 2008, a total of 7,872 equine sera were tested at the Centre of Veterinary Institutes of Athens. Antibodies against seven infectious diseases of equids were determined: equine infectious anaemia (EIA), African horse sickness (AHS), equine viral arteritis (EVA), West Nile encephalitis (WNE), glanders, piroplasmosis and dourine. Tests for the four viral diseases found 4.5% seropositivity for EIA, 0% for AHS, 3.3% for EVA and 4% for WNE. All sera tested for glanders antibodies were negative. Tests for piroplasmosis detected antibodies against T. equi and B. caballi in 12.9% and 1.3% of the sera, respectively. No sample tested positive for dourine. The results of this epidemiological survey provide strong evidence that Greece is free from the diseases of AHS, glanders and dourine.
49. An 11-year-old boy with long lasting headaches
- Author
-
Kafetzis Dimitrios, Kallinikou Dimitra, Kossiva Lydia, Vraila Venetia-Maria, and Vougiouka Olga
- Subjects
Pediatrics ,RJ1-570 ,Diseases of the musculoskeletal system ,RC925-935 - Published
- 2011
- Full Text
- View/download PDF
50. Benign hypermobility syndrome in Greek schoolchildren.
- Author
-
Vougiouka, Olga, Moustaki, Maria, Tsanaktsi, Maria, Vougiouka, O, Moustaki, M, and Tsanaktsi, M
- Subjects
SYNDROMES in children ,DISEASES ,PRESCHOOL children - Abstract
Since the incidence of benign hypermobility syndrome is significantly high in otherwise healthy children, paediatricians should consider this benign entity when they evaluate musculoskeletal complaints in childhood. [ABSTRACT FROM AUTHOR]
- Published
- 2000
- Full Text
- View/download PDF
Catalog
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.