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14 results on '"Vormoor, H. Josef"'

1. Fludarabine exposure predicts outcome after CD19 CAR T-cell therapy in children and young adults with acute leukemia

Author

Dekker, Linde, Calkoen, Friso G., Jiang, Yilin, Blok, Hilly, Veldkamp, Saskia R., De Koning, Coco, Spoon, Maike, Admiraal, Rick, Hoogerbrugge, Peter, Vormoor, Britta, Vormoor, H. Josef, Visscher, Henk, Bierings, Marc, Van Der Vlugt, Marieke, Van Tinteren, Harm, Nijstad, A. Laura, Huitema, Alwin D.R., Van Der Elst, Kim C.M., Pieters, Rob, Lindemans, Caroline A., and Nierkens, Stefan

Published
2022
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2. Survival disparities between children and adolescents and young adults for the major subtypes of non-Hodgkin lymphoma in the Netherlands: a large population-based study

Author

PMC Medisch specialisten, Cancer, MS Hematologie, Infection & Immunity, Regenerative Medicine and Stem Cells, Schulpen, Maya, Beishuizen, Auke, Chamuleau, Martine E D, Dinmohamed, Avinash G, Meyer-Wentrup, Friederike A G, Vormoor, H Josef, Van der Wagen, Lotte E, Minnema, Monique C, Loeffen, Jan L C, Karim-Kos, Henrike E, PMC Medisch specialisten, Cancer, MS Hematologie, Infection & Immunity, Regenerative Medicine and Stem Cells, Schulpen, Maya, Beishuizen, Auke, Chamuleau, Martine E D, Dinmohamed, Avinash G, Meyer-Wentrup, Friederike A G, Vormoor, H Josef, Van der Wagen, Lotte E, Minnema, Monique C, Loeffen, Jan L C, and Karim-Kos, Henrike E

Published
2024

3. Survival disparities between children and adolescents and young adults for the major subtypes of non-Hodgkin lymphoma in the Netherlands:a large population-based study

Author

Schulpen, Maya, Beishuizen, Auke, Chamuleau, Martine E.D., Dinmohamed, Avinash G., Meyer-Wentrup, Friederike A.G., Vormoor, H. Josef, van der Wagen, Lotte E., Minnema, Monique C., Loeffen, Jan L.C., Karim-Kos, Henrike E., Schulpen, Maya, Beishuizen, Auke, Chamuleau, Martine E.D., Dinmohamed, Avinash G., Meyer-Wentrup, Friederike A.G., Vormoor, H. Josef, van der Wagen, Lotte E., Minnema, Monique C., Loeffen, Jan L.C., and Karim-Kos, Henrike E.

Published
2024

5. Survival disparities between children and adolescents and young adults for the major subtypes of non-Hodgkin lymphoma in the Netherlands: a large population-based study

Author

Schulpen, Maya, primary, Beishuizen, Auke, additional, Chamuleau, Martine E. D., additional, Dinmohamed, Avinash G., additional, Meyer-Wentrup, Friederike A. G., additional, Vormoor, H. Josef, additional, Van der Wagen, Lotte E., additional, Minnema, Monique C., additional, Loeffen, Jan L. C., additional, and Karim-Kos, Henrike E., additional

Published
2023
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6. Implementation of paediatric precision oncology into clinical practice: The Individualized Therapies for Children with cancer program ‘iTHER’

Author

Langenberg, Karin P.S., Meister, Michael T., Bakhuizen, Jette J., Boer, Judith M., van Eijkelenburg, Natasha K.A., Hulleman, Esther, Ilan, Uri, Looze, Eleonora J., Dierselhuis, Miranda P., van der Lugt, Jasper, Breunis, Willemijn, Schild, Linda G., Ober, Kimberley, van Hooff, Sander R., Scheijde-Vermeulen, Marijn A., Hiemcke-Jiwa, Laura S., Flucke, Uta E., Kranendonk, Mariette E.G., Wesseling, Pieter, Sonneveld, Edwin, Punt, Simone, Boltjes, Arjan, van Dijk, Freerk, Verwiel, Eugene T.P., Volckmann, Richard, Hehir-Kwa, Jayne Y., Kester, Lennart A., Koudijs, Marco M.J., Waanders, Esme, Holstege, Frank C.P., Vormoor, H. Josef, Hoving, Eelco W., van Noesel, Max M., Pieters, Rob, Kool, Marcel, Stumpf, Miriam, Blattner-Johnson, Mirjam, Balasubramanian, Gnana P., Van Tilburg, Cornelis M., Jones, Barbara C., Jones, David T.W., Witt, Olaf, Pfister, Stefan M., Jongmans, Marjolijn C.J., Kuiper, Roland P., de Krijger, Ronald R., Wijnen, Marc H.W., den Boer, Monique L., Zwaan, C. Michel, Kemmeren, Patrick, Koster, Jan, Tops, Bastiaan B.J., Goemans, Bianca F., Molenaar, Jan J., Dep Scheikunde, Afd Pharmaceutics, Pharmaceutics, Dep Scheikunde, Afd Pharmaceutics, Pharmaceutics, Center of Experimental and Molecular Medicine, Oncogenomics, and CCA - Cancer Treatment and Quality of Life

Subjects
Cancer Research, Adolescent, Molecular biology, Precision medicine, High-Throughput Nucleotide Sequencing, Medical Oncology, Hereditary, Oncology, Neoplasms, Mutation, Exome Sequencing, Next-generation sequencing, Humans, Molecular targeted therapy, Prospective Studies, Child, Cancer
Abstract

iTHER is a Dutch prospective national precision oncology program aiming to define tumour molecular profiles in children and adolescents with primary very high-risk, relapsed, or refractory paediatric tumours. Between April 2017 and April 2021, 302 samples from 253 patients were included. Comprehensive molecular profiling including low-coverage whole genome sequencing (lcWGS), whole exome sequencing (WES), RNA sequencing (RNA-seq), Affymetrix, and/or 850k methylation profiling was successfully performed for 226 samples with at least 20% tumour content. Germline pathogenic variants were identified in 16% of patients (35/219), of which 22 variants were judged causative for a cancer predisposition syndrome. At least one somatic alteration was detected in 204 (90.3%), and 185 (81.9%) were considered druggable, with clinical priority very high (6.1%), high (21.3%), moderate (26.0%), intermediate (36.1%), and borderline (10.5%) priority. iTHER led to revision or refinement of diagnosis in 8 patients (3.5%). Temporal heterogeneity was observed in paired samples of 15 patients, indicating the value of sequential analyses. Of 137 patients with follow-up beyond twelve months, 21 molecularly matched treatments were applied in 19 patients (13.9%), with clinical benefit in few. Most relevant barriers to not applying targeted therapies included poor performance status, as well as limited access to drugs within clinical trial. iTHER demonstrates the feasibility of comprehensive molecular profiling across all ages, tumour types and stages in paediatric cancers, informing of diagnostic, prognostic, and targetable alterations as well as reportable germline variants. Therefore, WES and RNA-seq is nowadays standard clinical care at the Princess Máxima Center for all children with cancer, including patients at primary diagnosis. Improved access to innovative treatments within biology-driven combination trials is required to ultimately improve survival.

Published
2022

9. Implementation of paediatric precision oncology into clinical practice: The Individualized Therapies for Children with cancer program ‘iTHER’

Author

Dep Scheikunde, Afd Pharmaceutics, Pharmaceutics, Langenberg, Karin P.S., Meister, Michael T., Bakhuizen, Jette J., Boer, Judith M., van Eijkelenburg, Natasha K.A., Hulleman, Esther, Ilan, Uri, Looze, Eleonora J., Dierselhuis, Miranda P., van der Lugt, Jasper, Breunis, Willemijn, Schild, Linda G., Ober, Kimberley, van Hooff, Sander R., Scheijde-Vermeulen, Marijn A., Hiemcke-Jiwa, Laura S., Flucke, Uta E., Kranendonk, Mariette E.G., Wesseling, Pieter, Sonneveld, Edwin, Punt, Simone, Boltjes, Arjan, van Dijk, Freerk, Verwiel, Eugene T.P., Volckmann, Richard, Hehir-Kwa, Jayne Y., Kester, Lennart A., Koudijs, Marco M.J., Waanders, Esme, Holstege, Frank C.P., Vormoor, H. Josef, Hoving, Eelco W., van Noesel, Max M., Pieters, Rob, Kool, Marcel, Stumpf, Miriam, Blattner-Johnson, Mirjam, Balasubramanian, Gnana P., Van Tilburg, Cornelis M., Jones, Barbara C., Jones, David T.W., Witt, Olaf, Pfister, Stefan M., Jongmans, Marjolijn C.J., Kuiper, Roland P., de Krijger, Ronald R., Wijnen, Marc H.W., den Boer, Monique L., Zwaan, C. Michel, Kemmeren, Patrick, Koster, Jan, Tops, Bastiaan B.J., Goemans, Bianca F., Molenaar, Jan J., Dep Scheikunde, Afd Pharmaceutics, Pharmaceutics, Langenberg, Karin P.S., Meister, Michael T., Bakhuizen, Jette J., Boer, Judith M., van Eijkelenburg, Natasha K.A., Hulleman, Esther, Ilan, Uri, Looze, Eleonora J., Dierselhuis, Miranda P., van der Lugt, Jasper, Breunis, Willemijn, Schild, Linda G., Ober, Kimberley, van Hooff, Sander R., Scheijde-Vermeulen, Marijn A., Hiemcke-Jiwa, Laura S., Flucke, Uta E., Kranendonk, Mariette E.G., Wesseling, Pieter, Sonneveld, Edwin, Punt, Simone, Boltjes, Arjan, van Dijk, Freerk, Verwiel, Eugene T.P., Volckmann, Richard, Hehir-Kwa, Jayne Y., Kester, Lennart A., Koudijs, Marco M.J., Waanders, Esme, Holstege, Frank C.P., Vormoor, H. Josef, Hoving, Eelco W., van Noesel, Max M., Pieters, Rob, Kool, Marcel, Stumpf, Miriam, Blattner-Johnson, Mirjam, Balasubramanian, Gnana P., Van Tilburg, Cornelis M., Jones, Barbara C., Jones, David T.W., Witt, Olaf, Pfister, Stefan M., Jongmans, Marjolijn C.J., Kuiper, Roland P., de Krijger, Ronald R., Wijnen, Marc H.W., den Boer, Monique L., Zwaan, C. Michel, Kemmeren, Patrick, Koster, Jan, Tops, Bastiaan B.J., Goemans, Bianca F., and Molenaar, Jan J.

Published
2022

10. Implementation of paediatric precision oncology into clinical practice: The Individualized Therapies for Children with cancer program 'iTHER'

Author

Genetica Oper.Mang. Clinical Genetics, Cancer, PMC Medisch specialisten, Arts-assistenten Kinderen, Groep Holstege, Pathologie Pathologen staf, Pathologie Groep Van Diest, Brain, Hematologie ICAT, Infection & Immunity, CDL Cluster Onderzoek en Onderwijs, Pathologie Moleculair, Genetica Sectie Genoomdiagnostiek, Onderzoek Beeld, Child Health, Neurochirurgen, Zorg en O&O, Genetica Klinische Genetica, Genetica, Zorgeenheid Kinderchirurgie Medisch, Speerpunt, CMM, Langenberg, Karin P S, Meister, Michael T, Bakhuizen, Jette J, Boer, Judith M, van Eijkelenburg, Natasha K A, Hulleman, Esther, Ilan, Uri, Looze, Eleonora J, Dierselhuis, Miranda P, van der Lugt, Jasper, Breunis, Willemijn, Schild, Linda G, Ober, Kimberley, van Hooff, Sander R, Scheijde-Vermeulen, Marijn A, Hiemcke-Jiwa, Laura S, Flucke, Uta E, Kranendonk, Mariette E G, Wesseling, Pieter, Sonneveld, Edwin, Punt, Simone, Boltjes, Arjan, van Dijk, Freerk, Verwiel, Eugene T P, Volckmann, Richard, Hehir-Kwa, Jayne Y, Kester, Lennart A, Koudijs, Marco M J, Waanders, Esme, Holstege, Frank C P, Vormoor, H Josef, Hoving, Eelco W, van Noesel, Max M, Pieters, Rob, Kool, Marcel, Stumpf, Miriam, Blattner-Johnson, Mirjam, Balasubramanian, Gnana P, Van Tilburg, Cornelis M, Jones, Barbara C, Jones, David T W, Witt, Olaf, Pfister, Stefan M, Jongmans, Marjolijn C J, Kuiper, Roland P, de Krijger, Ronald R, Wijnen, Marc H W, den Boer, Monique L, Zwaan, C Michel, Kemmeren, Patrick, Koster, Jan, Tops, Bastiaan B J, Goemans, Bianca F, Molenaar, Jan J, Genetica Oper.Mang. Clinical Genetics, Cancer, PMC Medisch specialisten, Arts-assistenten Kinderen, Groep Holstege, Pathologie Pathologen staf, Pathologie Groep Van Diest, Brain, Hematologie ICAT, Infection & Immunity, CDL Cluster Onderzoek en Onderwijs, Pathologie Moleculair, Genetica Sectie Genoomdiagnostiek, Onderzoek Beeld, Child Health, Neurochirurgen, Zorg en O&O, Genetica Klinische Genetica, Genetica, Zorgeenheid Kinderchirurgie Medisch, Speerpunt, CMM, Langenberg, Karin P S, Meister, Michael T, Bakhuizen, Jette J, Boer, Judith M, van Eijkelenburg, Natasha K A, Hulleman, Esther, Ilan, Uri, Looze, Eleonora J, Dierselhuis, Miranda P, van der Lugt, Jasper, Breunis, Willemijn, Schild, Linda G, Ober, Kimberley, van Hooff, Sander R, Scheijde-Vermeulen, Marijn A, Hiemcke-Jiwa, Laura S, Flucke, Uta E, Kranendonk, Mariette E G, Wesseling, Pieter, Sonneveld, Edwin, Punt, Simone, Boltjes, Arjan, van Dijk, Freerk, Verwiel, Eugene T P, Volckmann, Richard, Hehir-Kwa, Jayne Y, Kester, Lennart A, Koudijs, Marco M J, Waanders, Esme, Holstege, Frank C P, Vormoor, H Josef, Hoving, Eelco W, van Noesel, Max M, Pieters, Rob, Kool, Marcel, Stumpf, Miriam, Blattner-Johnson, Mirjam, Balasubramanian, Gnana P, Van Tilburg, Cornelis M, Jones, Barbara C, Jones, David T W, Witt, Olaf, Pfister, Stefan M, Jongmans, Marjolijn C J, Kuiper, Roland P, de Krijger, Ronald R, Wijnen, Marc H W, den Boer, Monique L, Zwaan, C Michel, Kemmeren, Patrick, Koster, Jan, Tops, Bastiaan B J, Goemans, Bianca F, and Molenaar, Jan J

Published
2022

11. Fludarabine exposure predicts outcome after CD19 CAR T-cell therapy in children and young adults with acute leukemia

Author

CTI Van Wijk, Infection & Immunity, CTI Nierkens, Cancer, Onderzoek Beeld, Zorg en O&O, Apotheek Onderzoek, Apotheek O&O&O, Apotheek Klinische Farmacie, CDL Patiëntenzorg MI, CTI Research, Dekker, Linde, Calkoen, Friso G., Jiang, Yilin, Blok, Hilly, Veldkamp, Saskia R., De Koning, Coco, Spoon, Maike, Admiraal, Rick, Hoogerbrugge, Peter, Vormoor, Britta, Vormoor, H. Josef, Visscher, Henk, Bierings, Marc, Van Der Vlugt, Marieke, Van Tinteren, Harm, Nijstad, A. Laura, Huitema, Alwin D.R., Van Der Elst, Kim C.M., Pieters, Rob, Lindemans, Caroline A., Nierkens, Stefan, CTI Van Wijk, Infection & Immunity, CTI Nierkens, Cancer, Onderzoek Beeld, Zorg en O&O, Apotheek Onderzoek, Apotheek O&O&O, Apotheek Klinische Farmacie, CDL Patiëntenzorg MI, CTI Research, Dekker, Linde, Calkoen, Friso G., Jiang, Yilin, Blok, Hilly, Veldkamp, Saskia R., De Koning, Coco, Spoon, Maike, Admiraal, Rick, Hoogerbrugge, Peter, Vormoor, Britta, Vormoor, H. Josef, Visscher, Henk, Bierings, Marc, Van Der Vlugt, Marieke, Van Tinteren, Harm, Nijstad, A. Laura, Huitema, Alwin D.R., Van Der Elst, Kim C.M., Pieters, Rob, Lindemans, Caroline A., and Nierkens, Stefan

Published
2022

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