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44 results on '"Vondráček, Vladimír"'

3. Silicon Carbide Timepix3 detector for quantum-imaging detection and spectral tracking of charged particles in wide range of energy and field-of-view

Author

Novak, Andrej, Granja, Carlos, Sagatova, Andrea, Jakubek, Jan, Zatko, Bohumir, Vondracek, Vladimir, Andrlik, Michal, Zach, Vaclav, Polansky, Stepan, Rathi, Anuj, and Oancea, Cristina

Subjects
Physics - Instrumentation and Detectors, Physics - Medical Physics
Abstract

The hybrid architecture of the Timepix (TPX) family of detectors enables the use of different semiconductor sensors, most commonly silicon (Si), as well as high-density materials such as Cadmium Telluride (CdTe) or Gallium Arsenide (GaAs). For this purpose, we explore the potential of a silicon carbide (SiC) sensor bump-bonded on a Timepix3 detector as a radiation imaging and particle tracking detector. SiC stands as a radiation-hard material also with the ability to operate at elevated temperatures up to several hundreds of degrees Celsius. As a result, this sensor material is more suitable for radiation harsh environments compared to conventional e.g., Si sensors. In this work, we evaluate the response for precise radiation spectrometry and high-resolution particle tracking of newly developed SiC Timepix3 detector which is built and operated as a compact radiation camera MiniPIX-Timepix3 with integrated readout electronics. Calibration measurements were conducted with mono-energetic proton beams with energies of 13, 22, and 31 MeV at the U-120M cyclotron at the Nuclear Physics Institute Czech Academy of Science (NPI CAS), Prague, as well as 100 and 226 MeV at the Proton Therapy Center Czech (PTC) in Prague. High-resolution pattern recognition analysis and single-particle spectral tracking are used for detailed inspection and understanding of the sensor response. Results include distributions of deposited energy and linear energy transfer (LET) spectra. The spatial uniformity of the pixelated detector response is examined in terms of homogeneously distributed deposited energy., Comment: 9 pages, proceedings iWoRiD

Published
2023

4. The emerging role of Artificial Intelligence in proton therapy: A review

Author

Isaksson, Lars Johannes, Mastroleo, Federico, Vincini, Maria Giulia, Marvaso, Giulia, Zaffaroni, Mattia, Gola, Michał, Mazzola, Giovanni Carlo, Bergamaschi, Luca, Gaito, Simona, Alongi, Filippo, Doyen, Jerome, Fossati, Piero, Haustermans, Karin, Høyer, Morten, Langendijk, Johannes Albertus, Matute, Raùl, Orlandi, Ester, Schwarz, Marco, Troost, Esther G.C., Vondracek, Vladimir, La Torre, Davide, Curigliano, Giuseppe, Petralia, Giuseppe, Orecchia, Roberto, Alterio, Daniela, and Jereczek-Fossa, Barbara Alicja

Published
2024
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5. Clinical practice in European centres treating paediatric posterior fossa tumours with pencil beam scanning proton therapy

Author

Toussaint, Laura, Matysiak, Witold, Alapetite, Claire, Aristu, Javier, Bannink-Gawryszuk, Agata, Bolle, Stephanie, Bolsi, Alessandra, Calvo, Felipe, Cerron Campoo, Fernando, Charlwood, Frances, Demoor-Goldschmidt, Charlotte, Doyen, Jérôme, Drosik-Rutowicz, Katarzyna, Dutheil, Pauline, Embring, Anna, Engellau, Jacob, Goedgebeur, Anneleen, Goudjil, Farid, Harrabi, Semi, Kopec, Renata, Kristensen, Ingrid, Lægsdmand, Peter, Lütgendorf-Caucig, Carola, Meijers, Arturs, Mirandola, Alfredo, Missohou, Fernand, Montero Feijoo, Marta, Muren, Ludvig P., Ondrova, Barbora, Orlandi, Ester, Pettersson, Erik, Pica, Alessia, Plaude, Sandija, Righetto, Roberto, Rombi, Barbara, Timmermann, Beate, Van Beek, Karen, Vela, Anthony, Vennarini, Sabina, Vestergaard, Anne, Vidal, Marie, Vondracek, Vladimir, Weber, Damien C., Whitfield, Gillian, Zimmerman, Jens, Maduro, John H., and Lassen-Ramshad, Yasmin

Published
2024
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14. 5-Years Analysis of Effectivity and Toxicity of Ultra-Hypofractionated Proton Radiotherapy in the Treatment of Low- and Intermediate-Risk Prostate Cancer—A Retrospective Analysis

Author

Kubeš, Jiri, primary, Sláviková, Silvia, additional, Vítek, Pavel, additional, Haas, Alexandra, additional, Ondrová, Barbora, additional, Dedečková, Kateřina, additional, Andrlík, Michal, additional, Domanský, Martin, additional, Jiránková, Kateřina, additional, Schlencová, Veronika, additional, Harazimová, Anh, additional, Turková, Barbora, additional, Doležal, Tomáš, additional, Al-Hamami, Sarah Falah Abass, additional, and Vondráček, Vladimír, additional

Published
2023
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15. Profile of European proton and carbon ion therapy centers assessed by the EORTC facility questionnaire

Author

Weber, Damien C., Abrunhosa-Branquinho, André, Bolsi, Alessandra, Kacperek, Andrzej, Dendale, Rémi, Geismar, Dirk, Bachtiary, Barbara, Hall, Annika, Heufelder, Jens, Herfarth, Klaus, Debus, Jürgen, Amichetti, Maurizio, Krause, Mechthild, Orecchia, Roberto, Vondracek, Vladimir, Thariat, Juliette, Kajdrowicz, Tomasz, Nilsson, Kristina, and Grau, Cai

Published
2017
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18. MAILED DOSIMETRY AUDIT OF ACTIVE SCANNING PROTON BEAMS IN TEN PROTON THERAPY CENTERS

Author

Davídková, Marie, primary, Ankjærgaard, C, additional, Andersen, C.E., additional, Dasu, A., additional, De Angelis, C., additional, De Marzi, Ludovic, additional, De Saint-Hubert, Marijke, additional, Ekendahl, Daniela, additional, Henthorn, Nicholas, additional, Michaelidesová, Anna Jelínek, additional, Knežević, Željka, additional, Krzempek, Dawid, additional, Kukolowicz, Pawel, additional, Liszka, Małgorzata, additional, Lorentini, Stefano, additional, Leite, Amelia Maia, additional, Majer, Marija, additional, Navrátil, Matěj, additional, Reniers, Brigitte, additional, Ślusarczyk-Kacprzyk, Wioletta, additional, Van Goethem, Marc Jan, additional, Vestergaard, Anne, additional, Vilches-Freixas, Gloria, additional, Vondráček, Vladimír, additional, Togno, Michele, additional, Stolarczyk, Liliana, additional, and Olko, Pawel, additional

Published
2022
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20. Pencil‐beam scanning proton therapy for the treatment of glomus jugulare tumours

Author

Kubeš, Jiří, primary, Vondráček, Vladimír, additional, Andrlik, Michal, additional, Navrátil, Matěj, additional, Sláviková, Silvia, additional, Klika, Daniel, additional, Haas, Alexandra, additional, Dědečková, Kateřina, additional, Kopečková, Kateřina, additional, Ondrová, Barbora, additional, Rotnáglová, Eliška, additional, Vinakurau, Štěpán, additional, Grebenyuk, Alexander, additional, and Rosina, Jozef, additional

Published
2022
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21. Proton pencil-beam scanning radiotherapy in the treatment of nasopharyngeal cancer: dosimetric parameters and 2-year results

Author

Vítek Pavel, Sláviková Silvia, Patzelt Matěj, Navrátil Matěj, Prausová Jana, Lukeš Petr, Kubeš Jiří, Dědečková Kateřina, Andrlik Michal, Ondrová Barbora, Rosina Jozef, Vondráček Vladimír, Rotnáglová Eliška, and Grebenyuk Alexander

Subjects
Chemotherapy, medicine.medical_specialty, business.industry, medicine.medical_treatment, General Medicine, medicine.disease, Acute toxicity, Radiation therapy, 03 medical and health sciences, 0302 clinical medicine, Otorhinolaryngology, Nasopharyngeal carcinoma, 030220 oncology & carcinogenesis, Concomitant, medicine, Gastrectomy, Radiology, Stage (cooking), 030223 otorhinolaryngology, business, Proton therapy
Abstract

Patients with nasopharyngeal cancer are candidates for proton radiotherapy due to large and comprehensive target volumes, and the necessity for sparing of healthy tissues. The aim of this work is to evaluate treatment outcome and toxicity profile of patients treated with proton pencil-beam scanning radiotherapy. Between Jan 2013 and June 2018, 40 patients were treated for nasopharyngeal cancer (NPC) with IMPT (proton radiotherapy with modulated intensity). Median age was 47 years and the majority of patients had locally advanced tumors (stage 2–8 patients. (20%); stage 3–18 patients (45%); stage 4A–10 patients. (25%); stage 4B–4 patients. (10%). Median of total dose was 74 GyE (70–76 GyE) in 37 fractions (35–38). Bilateral neck irradiation was used in all cases. Concomitant chemotherapy was applied in 34 cases. (85%). Median follow-up time was 24 (1.5–62) months. Two-year overall survival (OS), disease-free survival (DFS), and local control (LC) were 80%, 75%, and 84%, respectively. Acute toxicity was generally mild despite large target volumes and concurrent application of chemotherapy with skin toxicity and dysphagia reported as the most frequent acute side effects. The insertion of a percutaneous endoscopic gastrectomy (PEG) was necessary in four cases (10%). Serious late toxicity (G > 3. RTOG) was observed in two patients (5%) (dysphagia and brain necrosis). IMPT for nasopharyngeal cancer patients is feasible with mild acute toxicity. Treatment outcomes are promising despite the high percentage of advanced disease in this group.

Published
2020
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22. Pencil Beam Scanning (PBS) Intensity-Modulated Proton Therapy (IMPT) Chemoradiotherapy for Anal Canal Cancer—Single Institution Experience

Author

Vítek, Pavel, primary, Kubeš, Jiří, additional, Vondráček, Vladimír, additional, Andrlik, Michal, additional, Navrátíl, Matěj, additional, Zapletal, Radek, additional, Haas, Alexandra, additional, Dědečková, Kateřina, additional, Ondrová, Barbora, additional, Grebenyuk, Alexander, additional, and Rosina, Jozef, additional

Published
2021
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23. Ultrahypofractionated Proton Radiation Therapy in the Treatment of Low and Intermediate-Risk Prostate Cancer-5-Year Outcomes

Author

Kubeš, Jiří, primary, Haas, Alexandra, additional, Vondráček, Vladimír, additional, Andrlík, Michal, additional, Navrátil, Matěj, additional, Sláviková, Silvia, additional, Vítek, Pavel, additional, Dědečková, Kateřina, additional, Prausová, Jana, additional, Ondrová, Barbora, additional, Vinakurau, Štěpán, additional, Grebenyuk, Alexander, additional, Doležal, Tomáš, additional, Velacková, Barbora, additional, and Rosina, Jozef, additional

Published
2021
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24. Proton pencil-beam scanning radiotherapy in the treatment of nasopharyngeal cancer: dosimetric parameters and 2-year results

Author

Kubeš, Jiří, Vondráček, Vladimír, Andrlik, Michal, Navrátil, Matěj, Sláviková, Silvia, Vítek, Pavel, Dědečková, Kateřina, Prausová, Jana, Ondrová, Barbora, Rotnáglová, Eliška, Lukeš, Petr, Patzelt, Matěj, Grebenyuk, Alexander, and Rosina, Jozef

Subjects
Nasopharyngeal Carcinoma, Proton Therapy, Humans, Nasopharyngeal Neoplasms, Radiotherapy Dosage, Radiotherapy, Intensity-Modulated, Middle Aged, Protons, Follow-Up Studies
Abstract

Patients with nasopharyngeal cancer are candidates for proton radiotherapy due to large and comprehensive target volumes, and the necessity for sparing of healthy tissues. The aim of this work is to evaluate treatment outcome and toxicity profile of patients treated with proton pencil-beam scanning radiotherapy. Between Jan 2013 and June 2018, 40 patients were treated for nasopharyngeal cancer (NPC) with IMPT (proton radiotherapy with modulated intensity). Median age was 47 years and the majority of patients had locally advanced tumors (stage 2-8 patients. (20%); stage 3-18 patients (45%); stage 4A-10 patients. (25%); stage 4B-4 patients. (10%). Median of total dose was 74 GyE (70-76 GyE) in 37 fractions (35-38). Bilateral neck irradiation was used in all cases. Concomitant chemotherapy was applied in 34 cases. (85%). Median follow-up time was 24 (1.5-62) months.Two-year overall survival (OS), disease-free survival (DFS), and local control (LC) were 80%, 75%, and 84%, respectively. Acute toxicity was generally mild despite large target volumes and concurrent application of chemotherapy with skin toxicity and dysphagia reported as the most frequent acute side effects. The insertion of a percutaneous endoscopic gastrectomy (PEG) was necessary in four cases (10%). Serious late toxicity (G 3. RTOG) was observed in two patients (5%) (dysphagia and brain necrosis). IMPT for nasopharyngeal cancer patients is feasible with mild acute toxicity. Treatment outcomes are promising despite the high percentage of advanced disease in this group.

Published
2020

25. In Vitro Comparison of Passive and Active Clinical Proton Beams

Author

Michaelidesová, Anna, primary, Vachelová, Jana, additional, Klementová, Jana, additional, Urban, Tomáš, additional, Pachnerová Brabcová, Kateřina, additional, Kaczor, Stanislav, additional, Falk, Martin, additional, Falková, Iva, additional, Depeš, Daniel, additional, Vondráček, Vladimír, additional, and Davídková, Marie, additional

Published
2020
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26. Treatment of young adult pineoblastoma pacient with proton beam therapy and high-dose chemoterapy

Author

Vinakurau, Stěpan, primary, Emmerová, Renata, additional, Engelová, Jana, additional, Sumerauer, David, additional, Ondrová, Barbora, additional, Kubeš, Jiří, additional, Vondráček, Vladimír, additional, Haas, Alexandra, additional, Jirásek, Tomáš, additional, Zámečník, Josef, additional, Buchvald, Pavel, additional, and Marečková, Zuzana, additional

Published
2020
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27. 498 - MAILED DOSIMETRY AUDIT OF ACTIVE SCANNING PROTON BEAMS IN TEN PROTON THERAPY CENTERS

Author

Davídková, Marie, Ankjærgaard, C, Andersen, C.E., Dasu, A., De Angelis, C., De Marzi, Ludovic, De Saint-Hubert, Marijke, Ekendahl, Daniela, Henthorn, Nicholas, Michaelidesová, Anna Jelínek, Knežević, Željka, Krzempek, Dawid, Kukolowicz, Pawel, Liszka, Małgorzata, Lorentini, Stefano, Leite, Amelia Maia, Majer, Marija, Navrátil, Matěj, Reniers, Brigitte, Ślusarczyk-Kacprzyk, Wioletta, Van Goethem, Marc Jan, Vestergaard, Anne, Vilches-Freixas, Gloria, Vondráček, Vladimír, Togno, Michele, Stolarczyk, Liliana, and Olko, Pawel

Published
2022
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37. Ruptured non-coronary sinus of Valsalva aneurysm into the right atrium in 44-year-old patient: Case report

Author

Slautin, Andrey, Mikulenka, Vladimír, Hlubocký, Jaroslav, Novotný, Róbert, Špaček, Miroslav, Vondráček, Vladimír, and Lindner, Jaroslav

Abstract

We hereby present a case report of ruptured sinus of Valsalva aneurysm into the right atrium in 44-year-old patient with 8-month progressive exertional dyspnoea, occasional palpitations and oedema of lower extremities. A massive left-to-right shunt between the outflow tract of the left ventricle and right atrium was discovered from the echocardiogram examination. The patient was indicated for surgery, during which it was discovered a defect in the area of the non-coronary sinus extending into the right atrium, calcifications in the annulus of the congenitally bicuspid aortic valve, without signs of endocarditis present, abundant tissue was excised from the right atrium which had originally been an aneurysm of the non-coronary sinus of the aortic root. Sinus of Valsalva aneurysm is a very rare pathology which is generally asymptomatic. In this case it manifested through a rupture into the right atrium and symptomatology of right-sided heart failure. Surgery was the only possible treatment.

Published
2024
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38. IT Technologies in Music Educations With Focus on CD-ROM

Author

Vondráček, Vladimír

Abstract

Magdalény Rettigové 4, 116 39 Praha 1 tel.: +420 221 900 111 www.pedf.cuni.cz IČ 00216208 DIČ CZ00216208 Dle čl. 4 Opatření rektora č. 6/2010 o Zpřístupnění elektronické databáze závěrečných prací http://www.cuni.cz/UK-3470.html a čl. 1 Opatření děkana 17/2010 se z časového hlediska závěrečné práce dělí do tří skupin: a. "nové práce", tj. práce odevzdávané k obhajobě počínaje 29. 9. 2010, b. "starší práce", tj. práce odevzdané k obhajobě od 1. 1. 2006 do 28. 9. 2010, c. "práce před rokem 2006", tj. práce odevzdané k obhajobě před 1. 1. 2006. V tomto případě jde o "starší práci" odevzdanou k obhajobě od 1. 1. 2006 do 28. 9. 2010. Omlouváme se, ale dokument není k dispozici.

Published
2008

43. Pencil Beam Scanning (PBS) Intensity-Modulated Proton Therapy (IMPT) Chemoradiotherapy for Anal Canal Cancer—Single Institution Experience.

Author

Vítek, Pavel, Kubeš, Jiří, Vondráček, Vladimír, Andrlik, Michal, Navrátíl, Matěj, Zapletal, Radek, Haas, Alexandra, Dědečková, Kateřina, Ondrová, Barbora, Grebenyuk, Alexander, and Rosina, Jozef

Subjects
EPITHELIAL cell tumors, BIOPSY, COLOSTOMY, RETROSPECTIVE studies, MAGNETIC resonance imaging, ANAL tumors, CHEMORADIOTHERAPY, TREATMENT effectiveness, RISK assessment, PROTON therapy, SPONTANEOUS cancer regression, DESCRIPTIVE statistics, SURVIVAL analysis (Biometry), DIGITAL diagnostic imaging, DRUG toxicity, DIGITAL rectal examination
Abstract

Simple Summary: Eligible patients received PBS IMPT at a single institution. Treatment was administered in two volumes: 1—tumour with margins plus involved lymph nodes; 2—regional lymph node groups: perirectal (mesorectal), obturatory, inguinal, internal, external, and common iliac. The total doses of 57.5 GyE and 45 GyE, respectively, were administered in volumes 1 and 2 in 25 fractions, 5 fractions per week, respectively (a simultaneous integrated boost). Concomitant chemotherapy cisplatinum (CDDP) plus 5-FU or CDDP plus capecitabine was administered as per protocol. This single-institution study showed the high efficacy of PBS IMPT, achieving a high rate of complete regression. The 2-year overall survival, relapse-free survival and colostomy-free survival were 94.2, 93.8 and 91.0%, respectively. The haematological acute toxicity of grade 3–4 remained low. The acute toxicity completely resolved in all patients and had no lethal outcomes. Background: A favourable dose distribution has been described for proton beam therapy (PBT) of anal cancer in dosimetric studies. The relationship between dosimetric parameters in bone marrow and haematologic toxicity, treatment interruptions, and treatment efficacy has also been documented. There are only few references on clinical results of PBT for anal cancer. The primary objective of the retrospective study was to assess the efficacy of pencil beam scanning intensity-modulated proton therapy (PBS IMPT) in the definitive chemoradiotherapy of anal cancer. Secondary objectives were established to identify the risks of acute chronic toxicity risks and to assess colostomy rates. Materials and methods: Patients were treated for biopsy-proven squamous cell cancer (SCC) of the anus at initial or advanced stages. Eligible patients received PBS IMPT at a single institution. Treatment was administered in two volumes: 1—tumour with margins plus involved lymph nodes; 2—regional lymph node groups: perirectal (mesorectal), obturatory, inguinal, internal, external, and common iliac. The total doses of 57.5 GyE and 45 GyE, respectively, were administered in volumes 1 and 2 in 25 fractions, 5 fractions per week, respectively (a simultaneous integrated boost). Concomitant chemotherapy cisplatinum (CDDP) plus 5-FU or CDDP plus capecitabine was administered as per protocol. The treatment effect was assessed using DRE (digital rectal examination) and MRI (magnetic resonance imaging) within the follow-up period. Toxicity was scaled using CTCAE version 4.0 criteria. Results: 39 of 41 patients treated during the period of February 2014–August 2021 were eligible for analysis. All patients completed treatment, 76.9% without interruption. The median treatment time was 35 days (32–35). The median follow-up period was 30 months, 34 patients are alive to-date, 5 patients died prior to the date of analysis, and 2 deaths were unrelated to the primary disease. The 2-year overall survival, relapse-free survival, and colostomy-free survival were 94.2%, 93.8%, and 91.0%, respectively. Complete regression was achieved in 36 patients (92.3%), partial regression was achieved in 2 (5.1%), and immediate progression at end of treatment occurred in 1 patient (2.6%). Salvage resection was indicated for two patients in partial regression and due to severe chronic dermatologic toxicity. The grade 3 and 4 haematological toxicity rates were 7.7% and 5.1%, respectively. The most frequent non-haematological acute toxicities of grade 3–4 observed were dermatitis (23.1%), diarrhoea (7.7%), and dehydration (7.7%). Chronic toxicity emerged predominantly as skin atrophy/ulceration grade 2 (26.5%) and grade 3–4 (5.8%), and radiation proctitis grade 2 (38.2%) and grade 3 (2.9%). Discussion, conclusions: This single-institution study showed the high efficacy of PBS IMPT, achieving a high rate of complete regression. The haematological acute toxicity of grade 3–4 remained low; however, the impact of altered chemotherapy (CDDP instead of mitomycin C) remains unclear. The incidence of other acute toxicities shares similarity with photon therapy investigated in large studies. The acute toxicity completely resolved in all patients, had no lethal outcomes, and never resulted in the necessity for colostomy. By contrast, it was chronic toxicity, skin ulceration, perirectal fistulation, and fibrosis that resulted in salvage surgery and/or the need for a colostomy. A challenging question remains: to what extent can PBT prevent chronic toxicity? Longer follow-up remains necessary. [ABSTRACT FROM AUTHOR]

Published
2022
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