631 results on '"Volpicelli, P"'
Search Results
2. Suppression of the JAK/STAT pathway inhibits neuroinflammation in the line 61-PFF mouse model of Parkinson’s disease
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Huixian Hong, Yong Wang, Marissa Menard, Jessica A. Buckley, Lianna Zhou, Laura Volpicelli-Daley, David G. Standaert, Hongwei Qin, and Etty N. Benveniste
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Parkinson’s disease ,Neuroinflammation ,α-Synuclein ,JAK/STAT ,AZD1480 ,scRNA-Seq ,Neurology. Diseases of the nervous system ,RC346-429 - Abstract
Abstract Parkinson’s disease (PD) is characterized by neuroinflammation, progressive loss of dopaminergic neurons, and accumulation of α-synuclein (α-Syn) into insoluble aggregates called Lewy pathology. The Line 61 α-Syn mouse is an established preclinical model of PD; Thy-1 is used to promote human α-Syn expression, and features of sporadic PD develop at 9–18 months of age. To accelerate the PD phenotypes, we injected sonicated human α-Syn preformed fibrils (PFFs) into the striatum, which produced phospho-Syn (p-α-Syn) inclusions in the substantia nigra pars compacta and significantly increased MHC Class II-positive immune cells. Additionally, there was enhanced infiltration and activation of innate and adaptive immune cells in the midbrain. We then used this new model, Line 61-PFF, to investigate the effect of inhibiting the JAK/STAT signaling pathway, which is critical for regulation of innate and adaptive immune responses. After administration of the JAK1/2 inhibitor AZD1480, immunofluorescence staining showed a significant decrease in p-α-Syn inclusions and MHC Class II expression. Flow cytometry showed reduced infiltration of CD4+ T-cells, CD8+ T-cells, CD19+ B-cells, dendritic cells, macrophages, and endogenous microglia into the midbrain. Importantly, single-cell RNA-Sequencing analysis of CD45+ cells from the midbrain identified 9 microglia clusters, 5 monocyte/macrophage (MM) clusters, and 5 T-cell (T) clusters, in which potentially pathogenic MM4 and T3 clusters were associated with neuroinflammatory responses in Line 61-PFF mice. AZD1480 treatment reduced cell numbers and cluster-specific expression of the antigen-presentation genes H2-Eb1, H2-Aa, H2-Ab1, and Cd74 in the MM4 cluster and proinflammatory genes such as Tnf, Il1b, C1qa, and C1qc in the T3 cluster. Together, these results indicate that inhibiting the JAK/STAT pathway suppresses the activation and infiltration of innate and adaptive cells, reducing neuroinflammation in the Line 61-PFF mouse model.
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- 2024
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3. Coronal Heating Rate in the Slow Solar Wind
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Telloni, Daniele, Romoli, Marco, Velli, Marco, Zank, Gary P., Adhikari, Laxman, Downs, Cooper, Burtovoi, Aleksandr, Susino, Roberto, Spadaro, Daniele, Zhao, Lingling, Liberatore, Alessandro, Shi, Chen, De Leo, Yara, Abbo, Lucia, Frassati, Federica, Jerse, Giovanna, Landini, Federico, Nicolini, Gianalfredo, Pancrazzi, Maurizio, Russano, Giuliana, Sasso, Clementina, Andretta, Vincenzo, Da Deppo, Vania, Fineschi, Silvano, Grimani, Catia, Heinzel, Petr, Moses, John D., Naletto, Giampiero, Stangalini, Marco, Teriaca, Luca, Uslenghi, Michela, Berlicki, Arkadiusz, Bruno, Roberto, Capobianco, Gerardo, Capuano, Giuseppe E., Casini, Chiara, Casti, Marta, Chioetto, Paolo, Corso, Alain J., D'Amicis, Raffaella, Fabi, Michele, Frassetto, Fabio, Giarrusso, Marina, Giordano, Silvio, Guglielmino, Salvo L., Magli, Enrico, Massone, Giuseppe, Messerotti, Mauro, Nisticò, Giuseppe, Pelizzo, Maria G., Reale, Fabio, Romano, Paolo, Schühle, Udo, Solanki, Sami K., Straus, Thomas, Ventura, Rita, Volpicelli, Cosimo A., Zangrilli, Luca, Zimbardo, Gaetano, Zuppella, Paola, Bale, Stuart D., and Kasper, Justin C.
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Astrophysics - Solar and Stellar Astrophysics ,Physics - Space Physics - Abstract
This Letter reports the first observational estimate of the heating rate in the slowly expanding solar corona. The analysis exploits the simultaneous remote and local observations of the same coronal plasma volume with the Solar Orbiter/Metis and the Parker Solar Probe instruments, respectively, and relies on the basic solar wind magnetohydrodynamic equations. As expected, energy losses are a minor fraction of the solar wind energy flux, since most of the energy dissipation that feeds the heating and acceleration of the coronal flow occurs much closer to the Sun than the heights probed in the present study, which range from 6.3 to 13.3 solar radii. The energy deposited to the supersonic wind is then used to explain the observed slight residual wind acceleration and to maintain the plasma in a non-adiabatic state. As derived in the Wentzel-Kramers-Brillouin limit, the present energy transfer rate estimates provide a lower limit, which can be very useful in refining the turbulence-based modeling of coronal heating and subsequent solar wind acceleration.
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- 2023
4. Suppression of the JAK/STAT pathway inhibits neuroinflammation in the line 61-PFF mouse model of Parkinson’s disease
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Hong, Huixian, Wang, Yong, Menard, Marissa, Buckley, Jessica A., Zhou, Lianna, Volpicelli-Daley, Laura, Standaert, David G., Qin, Hongwei, and Benveniste, Etty N.
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- 2024
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5. Lung ultrasound among Expert operator’S: ScOring and iNter-rater reliability analysis (LESSON study) a secondary COWS study analysis from ITALUS group
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Boero, Enrico, Gargani, Luna, Schreiber, Annia, Rovida, Serena, Martinelli, Giampaolo, Maggiore, Salvatore Maurizio, Urso, Felice, Camporesi, Anna, Tullio, Annarita, Lombardi, Fiorella Anna, Cammarota, Gianmaria, Biasucci, Daniele Guerino, Bignami, Elena Giovanna, Deana, Cristian, Volpicelli, Giovanni, Livigni, Sergio, and Vetrugno, Luigi
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- 2024
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6. Mediation role of interpersonal problems between insecure attachment and eating disorder psychopathology
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Carfagno, Marco, Barone, Eugenia, Arsenio, Eleonora, Bello, Rosaria, Marone, Luigi, Volpicelli, Antonio, Cascino, Giammarco, and Monteleone, Alessio Maria
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- 2024
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7. Clinical research on point-of-care lung ultrasound: misconceptions and limitations
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Volpicelli, Giovanni and Rovida, Serena
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- 2024
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8. Roberto Copetti, MD (1954–2024)
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Volpicelli, Giovanni
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- 2024
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9. Lung ultrasound among Expert operator’S: ScOring and iNter-rater reliability analysis (LESSON study) a secondary COWS study analysis from ITALUS group
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Enrico Boero, Luna Gargani, Annia Schreiber, Serena Rovida, Giampaolo Martinelli, Salvatore Maurizio Maggiore, Felice Urso, Anna Camporesi, Annarita Tullio, Fiorella Anna Lombardi, Gianmaria Cammarota, Daniele Guerino Biasucci, Elena Giovanna Bignami, Cristian Deana, Giovanni Volpicelli, Sergio Livigni, and Luigi Vetrugno
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Lung sonography ,Inter-rater variability ,Lung ultrasound score ,Intensive care ,Anesthesiology ,RD78.3-87.3 ,Medical emergencies. Critical care. Intensive care. First aid ,RC86-88.9 - Abstract
Abstract Background Lung ultrasonography (LUS) is a non-invasive imaging method used to diagnose and monitor conditions such as pulmonary edema, pneumonia, and pneumothorax. It is precious where other imaging techniques like CT scan or chest X-rays are of limited access, especially in low- and middle-income countries with reduced resources. Furthermore, LUS reduces radiation exposure and its related blood cancer adverse events, which is particularly relevant in children and young subjects. The score obtained with LUS allows semi-quantification of regional loss of aeration, and it can provide a valuable and reliable assessment of the severity of most respiratory diseases. However, inter-observer reliability of the score has never been systematically assessed. This study aims to assess experienced LUS operators’ agreement on a sample of video clips showing predefined findings. Methods Twenty-five anonymized video clips comprehensively depicting the different values of LUS score were shown to renowned LUS experts blinded to patients’ clinical data and the study’s aims using an online form. Clips were acquired from five different ultrasound machines. Fleiss-Cohen weighted kappa was used to evaluate experts’ agreement. Results Over a period of 3 months, 20 experienced operators completed the assessment. Most worked in the ICU (10), ED (6), HDU (2), cardiology ward (1), or obstetric/gynecology department (1). The proportional LUS score mean was 15.3 (SD 1.6). Inter-rater agreement varied: 6 clips had full agreement, 3 had 19 out of 20 raters agreeing, and 3 had 18 agreeing, while the remaining 13 had 17 or fewer people agreeing on the assigned score. Scores 0 and score 3 were more reproducible than scores 1 and 2. Fleiss’ Kappa for overall answers was 0.87 (95% CI 0.815–0.931, p
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- 2024
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10. Mediation role of interpersonal problems between insecure attachment and eating disorder psychopathology
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Marco Carfagno, Eugenia Barone, Eleonora Arsenio, Rosaria Bello, Luigi Marone, Antonio Volpicelli, Giammarco Cascino, and Alessio Maria Monteleone
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Eating disorders ,Attachment ,Interpersonal problems ,Psychopathology ,Mediation analysis ,Nutritional diseases. Deficiency diseases ,RC620-627 - Abstract
Abstract Purpose Although insecure attachment and interpersonal problems have been acknowledged as risk and maintaining factors of eating disorders (EDs), the mediating role of interpersonal problems between attachment style and ED psychopathology has been poorly explored. The purpose of this study was to investigate the mediating role of interpersonal problems between insecure attachment and ED psychopathology. Methods One-hundred-nine women with anorexia nervosa and 157 women with bulimia nervosa filled in the Eating Disorder Inventory-2 (EDI-2) and the Experiences in Close Relationships (ECR) revised scale to assess ED core symptoms and attachment styles, respectively. Interpersonal difficulties were evaluated by the Inventory of Interpersonal Problems (IIP-32). A mediator’s path model was conducted with anxious and avoidant attachment subscores as independent variables, ED core symptoms as dependent variables and interpersonal difficulties as mediators. The diagnosis was entered in the model as a confounding factor. Results The socially inhibited/avoidant interpersonal dimension was a mediator between avoidant attachment and the drive to thinness as well as between avoidant attachment and body dissatisfaction. An indirect connection was found between attachment-related anxiety and bulimic symptoms through the mediation of intrusive/needy score. Conclusions Social avoidance and intrusiveness mediate the relationships between avoidant and anxious attachment styles and ED psychopathology. These interpersonal problems may represent specific targets for psychotherapeutic treatments in individuals with EDs and insecure attachment. Level of evidence Level III: Evidence obtained from well-designed cohort or case–control analytic studies.
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- 2024
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11. Simultaneous post-neurosurgical ventriculitis and bacteraemia by two different strains of KPC-producing K. pneumoniae successfully treated with meropenem/vaborbactam and high dose of fosfomycin
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Lorenzo Volpicelli, Sara Cairoli, Dania Al Ismail, Floriana Baisi, Federica Sacco, Bianca Maria Goffredo, Mario Venditti, and Alessandra Oliva
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KPC ,Ventriculitis ,Meropenem/vaborbactam ,Fosfomycin ,Therapeutic drug monitoring ,Microbiology ,QR1-502 - Abstract
Objective: A case of post-neurosurgical ventriculitis caused by a KPC-producing Klebsiella pneumoniae (KPC-Kp) with a ceftazidime/avibactam-resistant, meropenem-susceptible phenotype is reported. Methods and results: The patient had a concomitant bloodstream infection with a wild-type KPC-Kp with a ceftazidime/avibactam-susceptible, meropenem-resistant phenotype. Prolonged treatment with intravenous fosfomycin and meropenem/vaborbactam achieved clinical success.Therapeutic drug monitoring performed during the first days of treatment showed for the first time that vaborbactam efficiently penetrates cerebrospinal fluid. In contrast, meropenem was undetectable in cerebrospinal fluid at each sampling, suggesting that additional doses of meropenem may be required to appropriately prescribe meropenem/vaborbactam for central nervous system infections. Plasma and cerebrospinal fluid levels of fosfomycin were adequate, confirming the potential of this agent possibly even in the fight against multidrug-resistant organisms. Conclusions: This case highlights the need for therapeutic drug monitoring as a crucial tool for optimizing treatment in complicated cases where the pharmacokinetic behaviour of antibiotics is difficult to predict.
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- 2024
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12. Clinical research on point-of-care lung ultrasound: misconceptions and limitations
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Giovanni Volpicelli and Serena Rovida
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Medical physics. Medical radiology. Nuclear medicine ,R895-920 - Abstract
Abstract Over the last 20 years, advances in point-of-care lung ultrasound (PoCLUS) have been consistent. The clinical application of PoCLUS has drastically changed the diagnosis of some respiratory conditions mainly in the acute setting. Despite these improvements, misconceptions regarding the current scientific evidence and errors in the direction given to the latest research are delaying the implementation of PoCLUS in the clinical field. The diagnostic power of PoCLUS is still under-evaluated in many settings and there is a generalized yet unjustified feeling that further evidence is needed before introducing PoCLUS as a standard of care. In the effort to build up further evidence by new studies, the role of randomized clinical trials is over-emphasized and gold standards used to investigate diagnostic accuracy of PoCLUS are sometimes not appropriate. Moreover, the sonographic patterns and techniques used to confirm the diagnoses not always are adapted to the patients’ clinical condition, which limit the scientific value of those clinical studies. Finally, there is a recurrent confusion in the role of PoCLUS scoring techniques, which should be only applied to quantify and monitor injury severity and not to diagnose lung diseases. Awareness of these misconceptions and errors could help the researchers when approaching new study projects on PoCLUS.
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- 2024
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13. Impact of emotional abuse on eating disorder psychopathology: A multiple mediation analysis
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Barone Eugenia, Carfagno Marco, Marafioti Niccolò, Bello Rosaria, Arsenio Eleonora, Marone Luigi, Volpicelli Antonio, Cascino Giammarco, and Monteleone Alessio Maria
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Eating disorders ,Childhood maltreatment ,Emotional abuse ,Psychopathology ,Mediation analysis ,Psychiatry ,RC435-571 - Abstract
Introduction: Childhood maltreatment, particularly emotional abuse (EA), has been identified as a significant risk factor for the development of eating disorders (EDs). This study investigated the association between EA and ED symptoms while considering multiple potential mediators. Methods: Participants included 151 individuals with Anorexia Nervosa (AN), 115 with Bulimia Nervosa (BN), and 108 healthy controls. The Childhood trauma questionnaire, the Toronto Alexithymia scale, the Behavioral inhibition System, and the Eating Disorder Inventory 2 scale were completed before treatment. A mediator path model was conducted in each group: EA was set as independent variable, eating symptoms as dependent variables and ineffectiveness, sensitivity to punishment, alexithymia, and impulsivity as mediators. Results: In individuals with AN, impulsivity emerged as a significant mediator between EA and desire for thinness and bulimic behaviors. Conversely, in individuals with BN, sensitivity to punishment was found to mediate the association between EA and dissatisfaction with one's body.Ineffectiveness and difficulty identifying emotions were identified as transdiagnostic mediators in both clinical groups. No mediation effect was found in healthy individuals. Discussion: The simultaneous assessment of multiple mediators in a unique model outlines the complex interplay between childhood EA and ED psychopathology. Improving ineffectiveness, emotion identification, sensitivity to punishment and impulsivity and exploring their relations with early emotional abuse may represent treatment targets in individuals with EDs and childhood trauma.
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- 2024
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14. Trabecular bone score assessed by dual-energy X ray absorption predicts vertebral fractures in HIV infected young adults
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Teresa Mannarino, Adriana D'Antonio, Simona Mercinelli, Maria Falzarano, Federica Volpicelli, Ciro Gabriele Mainolfi, Emanuela Zappulo, Giovanni Di Filippo, Maria Rosaria Cotugno, Ivan Gentile, and Alberto Cuocolo
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Human immunodeficiency virus ,HIV ,Osteoporosis ,Trabecular bone score ,Diseases of the musculoskeletal system ,RC925-935 - Abstract
Introduction: Bone mineral density (BMD) is reduced in patients with human immunodeficiency virus (HIV) infection. Trabecular bone score (TBS) is an additional feature calculated by dual-energy X ray absorption (DXA) that measures texture inhomogeneity at lumbar spine level, providing an index of bone microarchitecture. However, its clinical value still needs to be fully addressed. Aims of the study were to assess BMD and TBS in a cohort of patients with HIV compared to a population of healthy subjects and to investigate the prognostic value of TBS in HIV infected patients. Method: Bone health was assessed by DXA in 165 patients with HIV infection (120 men, mean age 40 ± 7 years) and in 164 healthy subjects (53 male, mean age 37 ± 10 years). BMD was measured at level of lumbar spine (L1-L4), femoral neck and total hip. TBS was computed from the images of lumbar spine using machine proprietary software. Results: BMD at femoral neck level was similar in HIV infected patients and healthy subjects (p = 0.57), whereas BMD measured in total femur was lower in HIV infected patients compared to healthy subjects (p
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- 2024
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15. Excitatory synaptic structural abnormalities produced by templated aggregation of α-syn in the basolateral amygdala
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Nolwazi Z. Gcwensa, Dreson L. Russell, Khaliah Y. Long, Charlotte F. Brzozowski, Xinran Liu, Karen L. Gamble, Rita M. Cowell, and Laura A. Volpicelli-Daley
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Parkinson's disease ,Dementia with Lewy bodies ,Basolateral amygdala ,Glutamatergic ,Presynaptic terminal ,Synapses ,Neurosciences. Biological psychiatry. Neuropsychiatry ,RC321-571 - Abstract
Parkinson's disease (PD) and Dementia with Lewy bodies (DLB) are characterized by neuronal α-synuclein (α-syn) inclusions termed Lewy Pathology, which are abundant in the amygdala. The basolateral amygdala (BLA), in particular, receives projections from the thalamus and cortex. These projections play a role in cognition and emotional processing, behaviors which are impaired in α-synucleinopathies. To understand if and how pathologic α-syn impacts the BLA requires animal models of α-syn aggregation. Injection of α-syn pre-formed fibrils (PFFs) into the striatum induces robust α-syn aggregation in excitatory neurons in the BLA that corresponds with reduced contextual fear conditioning. At early time points after aggregate formation, cortico-amygdala excitatory transmission is abolished. The goal of this project was to determine if α-syn inclusions in the BLA induce synaptic degeneration and/or morphological changes. In this study, we used C57BL/6 J mice injected bilaterally with PFFs in the dorsal striatum to induce α-syn aggregate formation in the BLA. A method was developed using immunofluorescence and three-dimensional reconstruction to analyze excitatory cortico-amygdala and thalamo-amygdala presynaptic terminals closely juxtaposed to postsynaptic densities. The abundance and morphology of synapses were analyzed at 6- or 12-weeks post-injection of PFFs. α-Syn aggregate formation in the BLA did not cause a significant loss of synapses, but cortico-amygdala and thalamo-amygdala presynaptic terminals and postsynaptic densities with aggregates of α-syn show increased volumes, similar to previous findings in human DLB cortex, and in non-human primate models of PD. Transmission electron microscopy showed that asymmetric synapses in mice with PFF-induced α-syn aggregates have reduced synaptic vesicle intervesicular distances, similar to a recent study showing phospho-serine-129 α-syn increases synaptic vesicle clustering. Thus, pathologic α-syn causes major alterations to synaptic architecture in the BLA, potentially contributing to behavioral impairment and amygdala dysfunction observed in synucleinopathies.
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- 2024
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16. A role for ceftazidime/avibactam combination therapy: the question may still be on the table
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Volpicelli, Lorenzo and Oliva, Alessandra
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- 2024
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17. Routine Use of a Standardized Mastectomy Diagram by Surgeons Improves Accuracy and Timeliness of the Final Pathological Report
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Seto, Andrew, Pass, Alexandra, Babkowski, Robert, Volpicelli, Elgida R., Cheng, Zandra, and Pass, Helen A.
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- 2023
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18. Real-world use of imipenem/cilastatin/relebactam for the treatment of KPC-producing Klebsiella pneumoniae complex and difficult-to-treat resistance (DTR) Pseudomonas aeruginosa infections: a single-center preliminary experience
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Cristiana Leanza, Maria Teresa Mascellino, Lorenzo Volpicelli, Sara Covino, Antonio Falletta, Francesca Cancelli, Cristiana Franchi, Martina Carnevalini, Claudio M. Mastroianni, and Alessandra Oliva
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imipenem-relebactam ,KPC-producing Klebsiella pneumoniae ,imipenem/cilastatin/relebactam ,ceftazidime-avibactam resistance ,polymicrobial infections ,antimicrobial resistance ,Microbiology ,QR1-502 - Abstract
IntroductionReal-life experience with imipenem/cilastatin/relebactam (IMI/REL) for the treatment of KPC-producing Klebsiella pneumoniae complex (KPC-Kp) and difficult-to-treat resistance (DTR) Pseudomonas aeruginosa (DTR-PA) infections is herein described.MethodsAdult patients with KPC-Kp or DTR-PA infections who received ≥48 h of IMI/REL were included. Clinical and microbiological outcomes were retrieved through the medical records. Primary outcome was clinical cure. Secondary outcomes included mortality from infection onset and adverse effects attributable to IMI/REL.ResultsWe included 10 patients with different infections caused by DTR-PA (n = 4), KPC-Kp [n = 5, of which 3 ceftazidime/avibactam-resistant (CTV-R KPC-Kp), 2 CTV susceptible (CTV-S KPC-Kp)] or both DTR-PA/KPC-Kp (n = 1) successfully treated with IMI/REL: 3 hospital-acquired pneumonia, 1 ventilator-associated pneumonia, 2 skin and soft tissue infections, 1 osteomyelitis, 2 bloodstream infections, 1 complicated urinary tract infection. Clinical cure was achieved in all cases. No patients died and no side effect were reported.DiscussionWe reported the preliminary real-life experience on the successful and safe use of IMI/REL for the treatment of KPC-Kp or DTR-PA complicated infections, including pneumonia and bone infections.
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- 2024
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19. Left bundle branch pacing and cardiac remodeling in HF patients with type 2 diabetes mellitus: epigenetic pathways and clinical outcomes
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Celestino Sardu, Ludovica Vittoria Marfella, Valerio Giordano, Caterina Claudia Lepre, Giovanbattista D’Amico, Mario Volpicelli, Carla Contaldi, Raffaele Galiero, Alfredo Caturano, Flavia Casolaro, Ferdinando Carlo Sasso, Carlo Uran, Domenico Cozzolino, Maddalena Nicoletti, Giuseppe Signoriello, Giuseppe Paolisso, and Raffaele Marfella
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heart failure ,cardiac remodeling ,reduced EF ,T2DM ,CRTd ,Therapeutics. Pharmacology ,RM1-950 - Abstract
BackgroundLeft bundle branch (LBB) pacing could achieve cardiac resynchronization therapy (CRT) in patients who cannot be resynchronized via the placement of the left ventricle (LV) lead into the coronary sinus. LBB pacing could improve cardiovascular outcomes in heart failure (HF) patients with LBB block who are affected by type 2 diabetes mellitus (T2DM).Study hypothesisLBB pacing could increase the number of CRT responders and lead to the best clinical outcomes in HF patients with T2DM, inducing cardiac remodeling and improving left ventricle ejection fraction (LVEF) via microRNA (miR) modulation.MethodsIn a multicenter observational study, we enrolled 334 HF patients with LBB block and an indication to receive LBB pacing for CRT. In these patients, we evaluated the CRT responder rate, clinical outcomes, and miR expression at 1 year of follow-up.ResultsAt 1 year of follow-up, we had 223 responders (66.8%), 132 hospitalizations for HF (39.5%), 24 cardiac deaths (7.2%), and 37 all-cause deaths (11.1%), with a higher rate of HF hospitalizations (77 (69.4%) vs 55 (24.7%), p < 0.05), and cardiac deaths (13 (11.7% vs 11 (4.9%), p < 0.05) in non-responders vs responders. At the end of follow-up, we found the lowest expression of miR-26, miR-29, miR-30, miR-92, and miR-145 in LBB-pacing non-responders vs responders (p < 0.05), and a direct correlation between miR-30 (0.340, [0.833–1.915]; p 0.001), the 6-minute-walking test (6MWT; 0.168, [0.008–0.060]; p 0.011), angiotensin-receptor-neprilysin inhibitors (ARNI; 0.157, [0.183–4.877]; p 0.035), sodium-glucose-transporter-2 inhibitors (0.245, [2.242–7.283]; p 0.001), and LVEF improvements. C reactive protein (CRP) inversely correlated with LVEF improvement (−0.220, [-(0.066–0.263)]; p 0.001). ARNI (1.373, CI 95% [1.007–1.872], p 0.045), miR-30 (2.713, CI 95% [1.543–4.769], p 0.001), and 6MWT (1.288, CI 95% [1.084–1.998], p 0.001) were predictors of LBB pacing responders at 1 year of follow-up.ConclusionLBB-pacing responders evidenced miR modulation, which was linked to significant improvement of the cardiac pump. Specifically, miR-30 was linked to cardiac pump improvement and predicted responders at 1 year of follow-up in patients with T2DM.
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- 2024
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20. Facts and myths about use of esketamine for treatment-resistant depression: a narrative clinical review
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Matteo Di Vincenzo, Vassilis Martiadis, Bianca Della Rocca, Eleonora Arsenio, Andrea D’Arpa, Antonio Volpicelli, Mario Luciano, Gaia Sampogna, and Andrea Fiorillo
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treatment-resistant depression ,esketamine ,major depressive disorder ,recovery ,remission ,Psychiatry ,RC435-571 - Abstract
Introduction and aimsTreatment-resistant depression (TRD) occurs when at least two different antidepressants, taken at the right dosage, for adequate period of time and with continuity, fail to give positive clinical effects. Esketamine, the S-enantiomer of ketamine, was recently approved for TRD treatment from U.S. Food and Drug Administration and European Medicine Agency. Despite proved clinical efficacy, many misconceptions by clinicians and patients accompany this medication. We aimed to review the most common “false myths” regarding TRD and esketemine, counterarguing with evidence-based facts.MethodsThe keywords “esketamine”, “treatment resistance depression”, “depression”, “myth”, “mythology”, “pharmacological treatment”, and “misunderstanding” were entered in the main databases and combined through Boolean operators.ResultsMisconceptions regarding the TRD prevalence, clinical features and predictors have been found. With respect of esketamine, criteria to start treatment, dissociative symptoms, potential addiction and aspects of administration and monitoring, were found to be affected by false beliefs by clinicians and patients.Discussion and conclusionTRD represents a challenging condition, requiring precise diagnosis in order to achieve patient’s full recovery. Esketamine has been proved as an effective medication to treat TRD, although it requires precautions. Evidence can inform clinical practice, in order to offer this innovative treatment to all patients with TRD.
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- 2024
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21. Cellular and subcellular localization of Rab10 and phospho-T73 Rab10 in the mouse and human brain
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Vijay Singh, Marissa A. Menard, Geidy E. Serrano, Thomas G. Beach, Hien T. Zhao, Alexis Riley-DiPaolo, Nitya Subrahmanian, Matthew J. LaVoie, and Laura A. Volpicelli-Daley
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Rab10 ,pRab10 ,Antisense oligonucleotide ,Rab10 knock down ,Phosphorylation ,Mouse brain ,Neurology. Diseases of the nervous system ,RC346-429 - Abstract
Abstract Autosomal dominant pathogenic mutations in Leucine-rich repeat kinase 2 (LRRK2) cause Parkinson’s disease (PD). The most common mutation, G2019S-LRRK2, increases the kinase activity of LRRK2 causing hyper-phosphorylation of its substrates. One of these substrates, Rab10, is phosphorylated at a conserved Thr73 residue (pRab10), and is one of the most abundant LRRK2 Rab GTPases expressed in various tissues. The involvement of Rab10 in neurodegenerative disease, including both PD and Alzheimer’s disease makes pinpointing the cellular and subcellular localization of Rab10 and pRab10 in the brain an important step in understanding its functional role, and how post-translational modifications could impact function. To establish the specificity of antibodies to the phosphorylated form of Rab10 (pRab10), Rab10 specific antisense oligonucleotides were intraventricularly injected into the brains of mice. Further, Rab10 knock out induced neurons, differentiated from human induced pluripotent stem cells were used to test the pRab10 antibody specificity. To amplify the weak immunofluorescence signal of pRab10, tyramide signal amplification was utilized. Rab10 and pRab10 were expressed in the cortex, striatum and the substantia nigra pars compacta. Immunofluorescence for pRab10 was increased in G2019S-LRRK2 knockin mice. Neurons, astrocytes, microglia and oligodendrocytes all showed Rab10 and pRab10 expression. While Rab10 colocalized with endoplasmic reticulum, lysosome and trans-Golgi network markers, pRab10 did not localize to these organelles. However, pRab10, did overlap with markers of the presynaptic terminal in both mouse and human cortex, including α-synuclein. Results from this study suggest Rab10 and pRab10 are expressed in all brain areas and cell types tested in this study, but pRab10 is enriched at the presynaptic terminal. As Rab10 is a LRRK2 kinase substrate, increased kinase activity of G2019S-LRRK2 in PD may affect Rab10 mediated membrane trafficking at the presynaptic terminal in neurons in disease.
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- 2023
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22. Enduring Neurobiological Consequences of Early-Life Stress: Insights from Rodent Behavioral Paradigms
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Luisa Speranza, Kardelen Dalim Filiz, Pellegrino Lippiello, Maria Grazia Ferraro, Silvia Pascarella, Maria Concetta Miniaci, and Floriana Volpicelli
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anxiety ,cancer ,depression ,dopamine ,glucocorticoids ,neurotrophins ,Biology (General) ,QH301-705.5 - Abstract
Stress profoundly affects physical and mental health, particularly when experienced early in life. Early-life stress (ELS) encompasses adverse childhood experiences such as abuse, neglect, violence, or chronic poverty. These stressors can induce long-lasting changes in brain structure and function, impacting areas involved in emotion regulation, cognition, and stress response. Consequently, individuals exposed to high levels of ELS are at an increased risk for mental health disorders like depression, anxiety, and post-traumatic stress disorders, as well as physical health issues, including metabolic disorders, cardiovascular disease, and cancer. This review explores the biological and psychological consequences of early-life adversity paradigms in rodents, such as maternal separation or deprivation and limited bedding or nesting. The study of these experimental models have revealed that the organism’s response to ELS is complex, involving genetic and epigenetic mechanisms, and is associated with the dysregulation of physiological systems like the nervous, neuroendocrine, and immune systems, in a sex-dependent fashion. Understanding the impact of ELS is crucial for developing effective interventions and preventive strategies in humans exposed to stressful or traumatic experiences in childhood.
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- 2024
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23. Factors Associated with Anxiety, Depression, and Quality of Life in Patients with Psoriasis: A Cross-Sectional Study
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Salvatore Cipolla, Pierluigi Catapano, Antonio Fiorino Bonamico, Valeria De Santis, Roberta Murolo, Francesca Romano, Antonio Volpicelli, Francesco Perris, Ada Lo Schiavo, Michele Fabrazzo, and Francesco Catapano
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psoriasis ,quality of life ,anxiety ,depression ,affective disorders ,mental health ,Neurosciences. Biological psychiatry. Neuropsychiatry ,RC321-571 - Abstract
Background: Psoriasis is a chronic skin disorder affecting 2–3% of the global population, and is associated with several comorbidities, including psychiatric disorders. This study aimed to identify factors influencing anxiety, depression, and quality of life (QoL) in patients with psoriasis. Methods: This observational study included 112 patients diagnosed with psoriasis. Dermatological and psychiatric assessments were conducted using Psodisk, the Hamilton Anxiety Rating Scale (HAM-A), Hamilton Depression Rating Scale (HAM-D), Symptom Checklist-90-Revised (SCL-90-R), and 36-Item Short Form Health Survey (SF-36). Descriptive statistics, correlation analyses, and multivariate regression models were employed. Results: The sample was predominantly middle-aged males (mean age 48.91 years). Females (p < 0.001), patients with arthritis (p < 0.05), and those with a sedentary lifestyle (p < 0.05) showed higher anxiety and depression scores. Psodisk subscales significantly correlated with psychiatric symptoms and QoL measures (p < 0.001). Pain (B: 0.63, p < 0.05; B: −2.03, p < 0.01) and sleep disturbances (B: 0.68, p < 0.01; B: 0.60, p < 0.01; B: −1.46, p < 0.01; B: −1.57, p < 0.05; B: 3.91, p < 0.05) emerged as major predictors of poor mental health and reduced QoL. Conclusions. The study underscores the complex relationship between psoriasis, psychiatric comorbidities, and QoL. Key factors exacerbating anxiety and depression include female gender, arthritis, and sedentary lifestyle. Comprehensive management of psoriasis should address both dermatological and psychological aspects, with a focus on pain relief and improving sleep quality to enhance overall patient well-being.
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- 2024
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24. Use of Virtual Reality in School-Aged Children with Developmental Coordination Disorder: A Novel Approach
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Giulia Purpura, Valentina Di Giusto, Carla Fulvia Zorzi, Giusi Figliano, Mattia Randazzo, Valentina Volpicelli, Rosanna Blonda, Elena Brazzoli, Tarjn Reina, Silvia Rezzonico, Roberta Sala, and Anna Cavallini
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developmental coordination disorder ,neurodevelopmental disorders ,virtual reality ,technology ,rehabilitation ,children ,Chemical technology ,TP1-1185 - Abstract
Virtual reality (VR) applications in paediatric rehabilitation are recent but promising. This brief report describes a VR rehabilitation program for a small sample of children with Developmental Coordination Disorder (DCD). The program focused explicitly on executive functions, a key area of concern for this population. It was conducted over 11 weeks in the CARE Lab. This lab was designed with appropriate structural characteristics and sophisticated technology to provide a rehabilitative setting with recreational and semi-immersive features. Before and after the VR training, the children were evaluated in terms of visual attention, inhibition, planning abilities, and visual–motor coordination. The rehabilitation programs were customised according to the clinical needs and the functional profile of each patient, proposing different games with variable complexity levels. These preliminary results showed a global and clinically significant change in executive functions, especially visual attention and inhibition skills. These findings suggest interesting implications for clinical practice, providing new information for professionals regarding the application of VR in the field of paediatric rehabilitation.
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- 2024
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25. Evaluation of the Effectiveness of Combined Treatment with Intravaginal Diazepam and Pelvic Floor Rehabilitation in Patients with Vulvodynia by Ultrasound Monitoring of Biometric Parameters of Pelvic Muscles: A Pilot Study
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Lucia Merlino, Enrico Ciminello, Agnese Immacolata Volpicelli, Stefano Tillier, Marianna Francesca Pasquali, Mattia Dominoni, Barbara Gardella, Roberto Senatori, Barbara Dionisi, and Maria Grazia Piccioni
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vulvodynia ,pelvis floor ,rehabilitation ,pain ,Medicine - Abstract
(1) Background: Vulvodynia is characterized by vulvar pain for at least three months and may have related variables, one of these being pelvic floor hypertonus. The purpose of this study was to compare the therapeutic effectiveness of two weekly sessions of pelvic floor rehabilitation and 5 mg of vaginal diazepam daily vs. pelvic floor rehabilitation alone in individuals with vulvodynia. (2) Methods: A single-center, not-blind, randomized study enrolled 20 vulvodynic patients: A total of 10 were treated with dual therapy (intravaginal diazepam and pelvic floor rehabilitation), and 10 were treated with only pelvic floor rehabilitation. All of them underwent a pelvic floor ultrasound examination and VAS pain and Marinoff scale assessments before the beginning of therapy as well as three and six months later. (3) Results: The elevator plate angle ranged from 8.2 to 9.55 (p = 0.0005), hiatal area diameter ranged from 1.277 to 1.482 (p = 0.0002), levator symphysis distance ranged from 3.88 to 4.098 (p = 0.006), anorectal angle ranged from 121.9 to 125.49 (p = 0.006), Marinoff scale ranged from 2.3 to 1.4 (p = 0.009), and VAS scale ranged from 5.8 to 2.8 (p < 0.001). (4) Conclusions: This pilot study demonstrates that the suggested treatment improves the hypertonicity of the pelvic floor, as measured by ultrasound parameters, correlating with a reduction in symptomatology.
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- 2024
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26. Exploring the Solar Wind from its Source on the Corona into the Inner Heliosphere during the First Solar Orbiter - Parker Solar Probe Quadrature
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Telloni, Daniele, Andretta, Vincenzo, Antonucci, Ester, Bemporad, Alessandro, Capuano, Giuseppe E., Fineschi, Silvano, Giordano, Silvio, Habbal, Shadia, Perrone, Denise, Pinto, Rui F., Sorriso-Valvo, Luca, Spadaro, Daniele, Susino, Roberto, Woodham, Lloyd D., Zank, Gary P., Romoli, Marco, Bale, Stuart D., Kasper, Justin C., Auchère, Frédéric, Bruno, Roberto, Capobianco, Gerardo, Case, Anthony W., Casini, Chiara, Casti, Marta, Chioetto, Paolo, Corso, Alain J., Da Deppo, Vania, De Leo, Yara, de Wit, Thierry Dudok, Frassati, Federica, Frassetto, Fabio, Goetz, Keith, Guglielmino, Salvo L., Harvey, Peter R., Heinzel, Petr, Jerse, Giovanna, Korreck, Kelly E., Landini, Federico, Larson, Davin, Liberatore, Alessandro, Livi, Roberto, MacDowall, Robert J., Magli, Enrico, Malaspina, David M., Massone, Giuseppe, Messerotti, Mauro, Moses, John D., Naletto, Giampiero, Nicolini, Gianalfredo, Nisticò, Giuseppe, Panasenco, Olga, Pancrazzi, Maurizio, Pelizzo, Maria G., Pulupa, Marc, Reale, Fabio, Romano, Paolo, Sasso, Clementina, Schühle, Udo, Stangalini, Marco, Stevens, Michael L., Strachan, Leonard, Straus, Thomas, Teriaca, Luca, Uslenghi, Michela, Velli, Marco, Verscharen, Daniel, Volpicelli, Cosimo A., Whittlesey, Phyllis, Zangrilli, Luca, Zimbardo, Gaetano, and Zuppella, Paola
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Astrophysics - Solar and Stellar Astrophysics ,Physics - Plasma Physics ,Physics - Space Physics - Abstract
This Letter addresses the first Solar Orbiter (SO) -- Parker Solar Probe (PSP) quadrature, occurring on January 18, 2021, to investigate the evolution of solar wind from the extended corona to the inner heliosphere. Assuming ballistic propagation, the same plasma volume observed remotely in corona at altitudes between 3.5 and 6.3 solar radii above the solar limb with the Metis coronagraph on SO can be tracked to PSP, orbiting at 0.1 au, thus allowing the local properties of the solar wind to be linked to the coronal source region from where it originated. Thanks to the close approach of PSP to the Sun and the simultaneous Metis observation of the solar corona, the flow-aligned magnetic field and the bulk kinetic energy flux density can be empirically inferred along the coronal current sheet with an unprecedented accuracy, allowing in particular estimation of the Alfv\'en radius at 8.7 solar radii during the time of this event. This is thus the very first study of the same solar wind plasma as it expands from the sub-Alfv\'enic solar corona to just above the Alfv\'en surface., Comment: 10 pages, 4 figures
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- 2021
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27. Cellular and subcellular localization of Rab10 and phospho-T73 Rab10 in the mouse and human brain
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Singh, Vijay, Menard, Marissa A., Serrano, Geidy E., Beach, Thomas G., Zhao, Hien T., Riley-DiPaolo, Alexis, Subrahmanian, Nitya, LaVoie, Matthew J., and Volpicelli-Daley, Laura A.
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- 2023
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28. Lung ultrasound: are we diagnosing too much?
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Volpicelli, Giovanni, Fraccalini, Thomas, and Cardinale, Luciano
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- 2023
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29. First light observations of the solar wind in the outer corona with the Metis coronagraph
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Romoli, M., Antonucci, E., Andretta, V., Capuano, G. E., Da Deppo, V., De Leo, Y., Downs, C., Fineschi, S., Heinzel, P., Landini, F., Liberatore, A., Naletto, G., Nicolini, G., Pancrazzi, M., Sasso, C., Spadaro, D., Susino, R., Telloni, D., Teriaca, L., Uslenghi, M., Wang, Y. M., Bemporad, A., Capobianco, G., Casti, M., Fabi, M., Frassati, F., Frassetto, F., Giordano, S., Grimani, C., Jerse, G., Magli, E., Massone, G., Messerotti, M., Moses, D., Pelizzo, M. G., Romano, P., Schühle, U., Slemer, A., Stangalini, M., Straus, T., Volpicelli, C. A., Zangrilli, L., Zuppella, P., Abbo, L., Auchére, F., Cuadrado, R. Aznar, Berlicki, A., Bruno, R., Ciaravella, A., D'Amicis, R., Lamy, P., Lanzafame, A., Malvezzi, A. M., Nicolosi, P., Nisticò, G., Peter, H., Plainaki, C., Poletto, L., Reale, F., Solanki, S. K., Strachan, L., Tondello, G., Tsinganos, K., Velli, M., Ventura, R., Vial, J. C., Woch, J., and Zimbardo, G.
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Astrophysics - Solar and Stellar Astrophysics - Abstract
The investigation of the wind in the solar corona initiated with the observations of the resonantly scattered UV emission of the coronal plasma obtained with UVCS-SOHO, designed to measure the wind outflow speed by applying the Doppler dimming diagnostics. Metis on Solar Orbiter complements the UVCS spectroscopic observations, performed during solar activity cycle 23, by simultaneously imaging the polarized visible light and the HI Ly-alpha corona in order to obtain high-spatial and temporal resolution maps of the outward velocity of the continuously expanding solar atmosphere. The Metis observations, on May 15, 2020, provide the first HI Ly-alpha images of the extended corona and the first instantaneous map of the speed of the coronal plasma outflows during the minimum of solar activity and allow us to identify the layer where the slow wind flow is observed. The polarized visible light (580-640 nm), and the UV HI Ly-alpha (121.6 nm) coronal emissions, obtained with the two Metis channels, are combined in order to measure the dimming of the UV emission relative to a static corona. This effect is caused by the outward motion of the coronal plasma along the direction of incidence of the chromospheric photons on the coronal neutral hydrogen. The plasma outflow velocity is then derived as a function of the measured Doppler dimming. The static corona UV emission is simulated on the basis of the plasma electron density inferred from the polarized visible light. This study leads to the identification, in the velocity maps of the solar corona, of the high-density layer about +/-10 deg wide, centered on the extension of a quiet equatorial streamer present at the East limb where the slowest wind flows at about (160 +/- 18) km/s from 4 Rs to 6 Rs. Beyond the boundaries of the high-density layer, the wind velocity rapidly increases, marking the transition between slow and fast wind in the corona.
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- 2021
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30. Cosmic-ray flux predictions and observations for and with Metis on board Solar Orbiter
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Grimani, C., Andretta, V., Chioetto, P., Da Deppo, V., Fabi, M., Gissot, S., Naletto, G., Persici, A., Plainaki, C., Romoli, M., Sabbatini, F., Spadaro, D., Stangalini, M., Telloni, D., Uslenghi, M., Antonucci, E., Bemporad, A., Capobianco, G., Capuano, G., Casti, M., De Leo, Y., Fineschi, S., Frassati, F., Frassetto, F., Heinzel, P., Jerse, G., Landini, F., Liberatore, A., Magli, E., Messerotti, M., Moses, D., Nicolini, G., Pancrazzi, M., Pelizzo, M. G., Romano, P., Sasso, C., Schühle, U., Slemer, A., Straus, T., Susino, R., Teriaca, L., Volpicelli, C. A., von Forstner, J. L. Freiherr, and Zuppella, P.
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Astrophysics - Instrumentation and Methods for Astrophysics - Abstract
The Metis coronagraph is one of the remote sensing instruments hosted on board the ESA/NASA Solar Orbiter mission. Metis is devoted to carry out the first simultaneous imaging of the solar corona in both visible light (VL) and ultraviolet (UV). High-energy particles penetrate spacecraft materials and may limit the performance of on-board instruments. A study of galactic cosmic-ray (GCR) tracks observed in the first VL images gathered by Metis during the commissioning phase for a total of 60 seconds of exposure time is presented here. A similar analysis is planned for the UV channel. A prediction of the GCR flux up to hundreds of GeV is made here for the first part of the Solar Orbiter mission to study the Metis coronagraph performance. GCR model predictions are compared to observations gathered on board Solar Orbiter by the EPD/HET experiment in the range 10 MeV-100 MeV in the summer 2020 and with previous measurements. Estimated cosmic-ray fluxes above 70 MeV n$^{-1}$ have been also parameterized and used for Monte Carlo simulations aiming at reproducing the cosmic-ray track observations in the Metis coronagraph VL images. The same parameterizations can also be used to study the performance of other detectors. By comparing observations of cosmic-ray tracks in the Metis VL images with FLUKA Monte Carlo simulations of cosmic-ray interactions in the VL detector, it is found that cosmic rays fire a fraction of the order of 10$^{-4}$ of the whole image pixel sample. Therefore, cosmic rays do not affect sensibly the quality of Metis VL images. It is also found that the overall efficiency for cosmic-ray identification in the Metis VL images is approximately equal to the contribution of Z$>$2 particles. As a result, the Metis coronagraph may play the role of a proton monitor for long-term GCR variations during the overall mission duration., Comment: 11 pages, 7 figures, accepted for publication on Astronomy & Astrophysics
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- 2021
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31. SWELTO -- Space WEather Laboratory in Turin Observatory
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Bemporad, A., Abbo, L., Barghini, D., Benna, C., Biondo, R., Bonino, D., Capobianco, G., Carella, F., Cora, A., Fineschi, S., Frassati, F., Gardiol, D., Giordano, S., Liberatore, A., Mancuso, S., Mignone, A., Rasetti, S., Reale, F., Riva, A., Salvati, F., Susino, R., Volpicelli, A., and Zangrilli, L.
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Astrophysics - Solar and Stellar Astrophysics ,Astrophysics - Instrumentation and Methods for Astrophysics ,Physics - Space Physics - Abstract
SWELTO -- Space WEather Laboratory in Turin Observatory is a conceptual framework where new ideas for the analysis of space-based and ground-based data are developed and tested. The input data are (but not limited to) remote sensing observations (EUV images of the solar disk, Visible Light coronagraphic images, radio dynamic spectra, etc...), in situ plasma measurements (interplanetary plasma density, velocity, magnetic field, etc...), as well as measurements acquired by local sensors and detectors (radio antenna, fluxgate magnetometer, full-sky cameras, located in OATo). The output products are automatic identification, tracking, and monitoring of solar stationary and dynamic features near the Sun (coronal holes, active regions, coronal mass ejections, etc...), and in the interplanetary medium (shocks, plasmoids, corotating interaction regions, etc...), as well as reconstructions of the interplanetary medium where solar disturbances may propagate from the Sun to the Earth and beyond. These are based both on empirical models and numerical MHD simulations. The aim of SWELTO is not only to test new data analysis methods for future application for Space Weather monitoring and prediction purposes, but also to procure, test and deploy new ground-based instrumentation to monitor the ionospheric and geomagnetic responses to solar activity. Moreover, people involved in SWELTO are active in outreach to disseminate the topics related with Space Weather to students and the general public.
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- 2021
32. Luminous efficiency based on FRIPON meteors
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Drolshagen, Esther, Ott, Theresa, Koschny, Detlef, Drolshagen, Gerhard, Vaubaillon, Jeremie, Colas, Francois, Trigo-Rodriguez, Josep Maria, Zanda, Brigitte, Bouley, Sylvain, Jeanne, Simon, Malgoyre, Adrien, Birlan, Mirel, Vernazza, Pierre, Gardiol, Daniele, Nedelcu, Dan Alin, Rowe, Jim, Forcier, Mathieu, Asensio, Eloy Peña, Lamy, Herve, Ferrière, Ludovic, Barghini, Dario, Carbognani, Albino, Di Martino, Mario, Rasetti, Stefania, Valsecchi, Giovanni Battista, Volpicelli, Cosimo Antonio, Di Carlo, Matteo, Knapic, Cristina, Pratesi, Giovanni, Riva, Walter, Stirpe, Giovanna M., Zorba, Sonia, Hernandez, Olivier, Jehin, Emmanuel, Jobin, Marc, King, Ashley, Sanchez-Lavega, Agustin, Toni, Andrea, and Poppe, Björn
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Astrophysics - Earth and Planetary Astrophysics - Abstract
In meteor physics the luminous efficiency ${\tau}$ is used to convert the meteor's magnitude to the corresponding meteoroid's mass. However, lack of sufficiently accurate verification methods or adequate laboratory tests leave this parameter to be controversially discussed. In this work meteor/fireball data obtained by the Fireball Recovery and InterPlanetary Observation Network (FRIPON) was used to calculate the masses of the pre-atmospheric meteoroids which could in turn be compared to the meteor brightnesses to assess their luminous efficiencies. For that, deceleration-based formulas for the mass computation were used. We have found ${\tau}$-values, as well as the shape change coefficients, of 294 fireballs with determined masses in the range of $10^{-6}$ kg - $100$ kg. The derived ${\tau}$-values have a median of ${\tau}_{median}$ = 2.17 %. Most of them are on the order of 0.1 % - 10 %. We present how our values were obtained, compare them with data reported in the literature, and discuss several methods. A dependence of ${\tau}$ on the pre-atmospheric velocity of the meteor, $v_e$, is noticeable with a relation of ${\tau}=0.0023 \cdot v_e^{2.3}$. The higher luminous efficiency of fast meteors could be explained by the higher energy released. Fast meteoroids produce additional emission lines that radiate more efficiently in specific wavelengths due to the appearance of the so-called second component of higher temperature. Furthermore, a dependence of ${\tau}$ on the initial meteoroid mass, $M_e$, was found, with negative linear behaviour in log-log space: ${\tau}=0.48 \cdot M_e^{-0.47}$. This implies that the radiation of smaller meteoroids is more efficient.
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- 2020
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33. ASO Author Reflections: Standardized Mastectomy Diagrams Improve the Accuracy and Timeliness of Pathology Reports
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Seto, Andrew, Pass, Alexandra, Babkowski, Robert, Volpicelli, Elgida R., Cheng, Zandra, and Pass, Helen A.
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- 2023
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34. Roberto Copetti, MD (1954–2024)
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Giovanni Volpicelli
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Medical physics. Medical radiology. Nuclear medicine ,R895-920 - Published
- 2024
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35. Ceftazidime/avibactam-resistant meropenem-susceptible KPC-producing Klebsiella pneumoniae: Analysis of cases and evaluation of in vitro activity of fosfomycin-containing combinations
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A. Oliva, D. Al Ismail, G. Arcari, MC. Miele, E. Casali, F. Sacco, L. Volpicelli, M. De Angelis, M.T. Mascellino, F. Cancelli, G. Raponi, A. Carattoli, and M Venditti
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Ceftazidime/avibactam-resistant meropenem-susceptible KPC-producing Klebsiella pneumoniae KPC-variant ,Fosfomycin ,Synergism ,Carbapenems ,Meropenem/vaborbactam ,Microbiology ,QR1-502 - Abstract
ABSTRACT: Objectives: Little is known regarding outcomes and optimal therapeutic regimens of infections caused by Klebsiella pneumoniae carbapenemase-producing Klebsiella pneumoniae (KPC-Kp) resistant to ceftazidime/avibactam (CZA) and susceptible to meropenem (MEM). Although susceptible to MEM in vitro, the possibility of developing MEM resistance overtime is a concern. We describe the clinical characteristics of patients with colonization/infection due to KPC variants with a focus on the in vitro activity of fosfomycin (FOS)-containing combinations. Methods: Patients with colonization/infection due to a KPC variant were included. Fosfomycin susceptibility was performed by agar dilution method. Synergistic activity of FOS-based combinations was evaluated by gradient strip-agar diffusion method. The emergence of in vitro MEM resistance was also tested. Results: Eleven patients were included: eight with infection [four with ventilator-associated pneumonia and four with bloodstream infections] and three with colonization. Previous therapy with CZA was administered to all patients (with a mean cumulative duration of 23 days). All subjects with infection received meropenem, in monotherapy (n = 4) or with amikacin (n = 2) or fosfomycin (n = 2), and achieved clinical cure. A new CZA-susceptible and MEM-resistant KPC-Kp strain was subsequently isolated in three patients (27.3%). Meropenem/vaborbactam (MVB) showed high in vitro activity, while FOS+MEM combination was synergistic in 40% of cases. In vitro resistance to MEM was observed with maintenance of CZA resistance. Conclusions: Detection of KPC variants may occur within the same patient, especially if CZA has been previously administered. Although clinical success has been obtained with carbapenems, the emergence of MEM resistance is a concern. Fosfomycin plus meropenem is synergistic and may be a valuable combination option for KPC variants, while MVB may be considered in monotherapy. The detection of KPC variants in an endemic setting for KPC-Kp represents a worryingly emerging condition. The optimal therapeutic approach is still unknown and the development of meropenem resistance is of concern, which may lead to therapeutic failure in clinical practice. In these cases, the addition of fosfomycin to meropenem, or a more potent antibiotic, such as meropenem/vaborbactam, may be valuable therapeutic options.
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- 2023
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36. Metis Observation of the Onset of Fully Developed Turbulence in the Solar Corona
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Daniele Telloni, Luca Sorriso-Valvo, Gary P. Zank, Marco Velli, Vincenzo Andretta, Denise Perrone, Raffaele Marino, Francesco Carbone, Antonio Vecchio, Laxman Adhikari, Lingling Zhao, Sabrina Guastavino, Fabiana Camattari, Chen Shi, Nikos Sioulas, Zesen Huang, Marco Romoli, Ester Antonucci, Vania Da Deppo, Silvano Fineschi, Catia Grimani, Petr Heinzel, John D. Moses, Giampiero Naletto, Gianalfredo Nicolini, Daniele Spadaro, Marco Stangalini, Luca Teriaca, Michela Uslenghi, Lucia Abbo, Frédéric Auchère, Regina Aznar Cuadrado, Arkadiusz Berlicki, Roberto Bruno, Aleksandr Burtovoi, Gerardo Capobianco, Chiara Casini, Marta Casti, Paolo Chioetto, Alain J. Corso, Raffaella D’Amicis, Yara De Leo, Michele Fabi, Federica Frassati, Fabio Frassetto, Silvio Giordano, Salvo L. Guglielmino, Giovanna Jerse, Federico Landini, Alessandro Liberatore, Enrico Magli, Giuseppe Massone, Giuseppe Nisticò, Maurizio Pancrazzi, Maria G. Pelizzo, Hardi Peter, Christina Plainaki, Luca Poletto, Fabio Reale, Paolo Romano, Giuliana Russano, Clementina Sasso, Udo Schühle, Sami K. Solanki, Leonard Strachan, Thomas Straus, Roberto Susino, Rita Ventura, Cosimo A. Volpicelli, Joachim Woch, Luca Zangrilli, Gaetano Zimbardo, and Paola Zuppella
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Magnetohydrodynamics ,Interplanetary turbulence ,Space plasmas ,Solar corona ,Solar wind ,Astrophysics ,QB460-466 - Abstract
This Letter reports the first observation of the onset of fully developed turbulence in the solar corona. Long time series of white-light coronal images, acquired by Metis aboard Solar Orbiter at 2 minutes cadence and spanning about 10 hr, were studied to gain insight into the statistical properties of fluctuations in the density of the coronal plasma in the time domain. From pixel-by-pixel spectral frequency analysis in the whole Metis field of view, the scaling exponents of plasma fluctuations were derived. The results show that, over timescales ranging from 1 to 10 hr and corresponding to the photospheric mesogranulation-driven dynamics, the density spectra become shallower moving away from the Sun, resembling a Kolmogorov-like spectrum at 3 R _⊙ . According to the latest observation and interpretive work, the observed 5/3 scaling law for density fluctuations is indicative of the onset of fully developed turbulence in the corona. Metis observation-based evidence for a Kolmogorov turbulent form of the fluctuating density spectrum casts light on the evolution of 2D turbulence in the early stages of its upward transport from the low corona.
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- 2024
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37. A Case Study of the May 30th, 2017 Italian Fireball
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Carbognani, A., Barghini, D., Gardiol, D., di Martino, M., Valsecchi, G. B., Trivero, P., Buzzoni, A., Rasetti, S., Selvestrel, D., Knapic, C., Londero, E., Zorba, S., Volpicelli, C. A., Di Carlo, M., Vaubaillon, J., Marmo, C., Colas, F., Valeri, D., Zanotti, F., Morini, M., Demaria, P., Zanda, B., Bouley, S., Vernazza, P., Gattacceca, J., Rault, J. -L., Maquet, L., and Birlan, M.
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Astrophysics - Earth and Planetary Astrophysics - Abstract
On May 30th, 2017 at about 21h 09m 17s UTC a green bright fireball crossed the sky of north-eastern Italy. The fireball path was observed from some all-sky cameras starting from a mean altitude of $81.1 \pm 0.2$ km (Lat. $44.369^{\circ} \pm 0.002^{\circ}$ N; Long. $11.859^{\circ} \pm 0.002^{\circ}$ E) and extinct at $23.3 \pm 0.2$ km (Lat. $45.246^{\circ} \pm 0.002^{\circ}$ N; Long. $12.046^{\circ} \pm 0.002^{\circ}$ E), between the Italian cities of Venice and Padua. In this paper, on the basis of simple physical models, we will compute the atmospheric trajectory, analize the meteoroid atmospheric dynamics, the dark flight phase (with the strewn field) and compute the best heliocentric orbit of the progenitor body. Search for meteorites on the ground has not produced any results so far., Comment: 19 pages, 17 figures. Accepted for publication in The European Physical Journal PLUS
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- 2019
38. Metis: the Solar Orbiter visible light and ultraviolet coronal imager
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Antonucci, Ester, Romoli, Marco, Andretta, Vincenzo, Fineschi, Silvano, Heinzel, Petr, Moses, J. Daniel, Naletto, Giampiero, Nicolini, Gianalfredo, Spadaro, Daniele, Teriaca, Luca, Berlicki, Arkadiusz, Capobianco, Gerardo, Crescenzio, Giuseppe, Da Deppo, Vania, Focardi, Mauro, Frassetto, Fabio, Heerlein, Klaus, Landini, Federico, Magli, Enrico, Malvezzi, Andrea Marco, Massone, Giuseppe, Melich, Radek, Nicolosi, Piergiorgio, Noci, Giancarlo, Pancrazzi, Maurizio, Pelizzo, Maria G., Poletto, Luca, Sasso, Clementina, Schühle, Udo, Solanki, Sami K., Strachan, Leonard, Susino, Roberto, Tondello, Giuseppe, Uslenghi, Michela, Woch, Joachim, Abbo, Lucia, Bemporad, Alessandro, Casti, Marta, Dolei, Sergio, Grimani, Catia, Messerotti, Mauro, Ricci, Marco, Straus, Thomas, Telloni, Daniele, Zuppella, Paola, Auchère, Frederic, Bruno, Roberto, Ciaravella, Angela, Corso, Alain J., Copano, Miguel Alvarez, Cuadrado, Regina Aznar, D'Amicis, Raffaella, Enge, Reiner, Gravina, Alessio, Jejčič, Sonja, Lamy, Philippe, Lanzafame, Alessandro, Meierdierks, Thimo, Papagiannaki, Ioanna, Peter, Hardi, Rico, German Fernandez, Sertsu, Mewael Giday, Staub, Jan, Tsinganos, Kanaris, Velli, Marco, Ventura, Rita, Verroi, Enrico, Vial, Jean-Claude, Vives, Sebastien, Volpicelli, Antonio, Werner, Stephan, Zerr, Andreas, Negri, Barbara, Castronuovo, Marco, Gabrielli, Alessandro, Bertacin, Roberto, Carpentiero, Rita, Natalucci, Silvia, Marliani, Filippo, Cesa, Marco, Laget, Philippe, Morea, Danilo, Pieraccini, Stefano, Radaelli, Paolo, Sandri, Paolo, Sarra, Paolo, Cesare, Stefano, Del Forno, Felice, Massa, Ernesto, Montabone, Mauro, Mottini, Sergio, Quattropani, Daniele, Schillaci, Tiziano, Boccardo, Roberto, Brando, Rosario, Pandi, Arianna, Baietto, Cristian, Bertone, Riccardo, Alvarez-Herrero, Alberto, Parejo, Pilar García, Cebollero, María, Amoruso, Mauro, and Centonze, Vito
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Astrophysics - Solar and Stellar Astrophysics ,Astrophysics - Instrumentation and Methods for Astrophysics - Abstract
Metis is the first solar coronagraph designed for a space mission capable of performing simultaneous imaging of the off-limb solar corona in both visible and UV light. The observations obtained with Metis aboard the Solar Orbiter ESA-NASA observatory will enable us to diagnose, with unprecedented temporal coverage and spatial resolution, the structures and dynamics of the full corona from 1.7 $R_\odot$ to about 9 $R_\odot$. Due to the uniqueness of the Solar Orbiter mission profile, Metis will be able to observe the solar corona from a close vantage point (down to 0.28 AU), achieving out-of-ecliptic views with the increase of the orbit inclination over time. Moreover, observations near perihelion, during the phase of lower rotational velocity of the solar surface relative to the spacecraft, will allow longer-term studies of the coronal features. Thanks to a novel occultation design and a combination of a UV interference coating of the mirrors and a spectral bandpass filter, Metis images the solar corona simultaneously in the visible light band, between 580 and 640 nm, and in the UV H I Lyman-{\alpha} line at 121.6 nm. The coronal images in both the UV Lyman-{\alpha} and polarised visible light are obtained at high spatial resolution with a spatial scale down to about 2000 km and 15000 km at perihelion, in the cases of the visible and UV light, respectively. A temporal resolution down to 1 second can be achieved when observing coronal fluctuations in visible light. The Metis measurements will allow for complete characterisation of the main physical parameters and dynamics of the electron and neutral hydrogen/proton plasma components of the corona in the region where the solar wind undergoes acceleration and where the onset and initial propagation of coronal mass ejections take place, thus significantly improving our understanding of the region connecting the Sun to the heliosphere.
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- 2019
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39. Lung ultrasound: are we diagnosing too much?
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Giovanni Volpicelli, Thomas Fraccalini, and Luciano Cardinale
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Medical physics. Medical radiology. Nuclear medicine ,R895-920 - Abstract
Abstract The clinical use of lung ultrasound (LUS) has made more efficient many diagnostic processes at bedside. The great power of LUS is a superior diagnostic sensitivity in many applications, when compared to chest radiography (CXR). The implementation of LUS in emergency is contributing to reveal a growing number of radio-occult pulmonary conditions. In some diseases, the superior sensitivity of LUS is a great advantage, like for pneumothorax and pulmonary edema. Diagnosing at bedside pneumothoraxes, pulmonary congestions, and COVID-19 pneumonia that are visible by LUS but undetected by CXR may be decisive for appropriate management, and even for saving lives. However, in other conditions, like bacterial pneumonia and small peripheral infarctions due to subsegmental pulmonary embolism, the high sensitivity of LUS does not always lead to advantages. Indeed, we doubt that it is always necessary to treat by antibiotics patients suspected of lower respiratory tract infection, who show radio-occult pulmonary consolidations, and to treat by anticoagulation patients with small subsegmental pulmonary embolism. The possibility that we are overtreating radio-occult conditions should be investigated with dedicated clinical trials.
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- 2023
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40. Alpha-synuclein in Parkinson’s disease and other synucleinopathies: from overt neurodegeneration back to early synaptic dysfunction
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Paolo Calabresi, Alessandro Mechelli, Giuseppina Natale, Laura Volpicelli-Daley, Giulia Di Lazzaro, and Veronica Ghiglieri
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Cytology ,QH573-671 - Abstract
Abstract Although the discovery of the critical role of α-synuclein (α-syn) in the pathogenesis of Parkinson’s disease (PD) is now twenty-five years old, it still represents a milestone in PD research. Abnormal forms of α-syn trigger selective and progressive neuronal death through mitochondrial impairment, lysosomal dysfunction, and alteration of calcium homeostasis not only in PD but also in other α-syn-related neurodegenerative disorders such as dementia with Lewy bodies, multiple system atrophy, pure autonomic failure, and REM sleep behavior disorder. Furthermore, α-syn-dependent early synaptic and plastic alterations and the underlying mechanisms preceding overt neurodegeneration have attracted great interest. In particular, the presence of early inflammation in experimental models and PD patients, occurring before deposition and spreading of α-syn, suggests a mechanistic link between inflammation and synaptic dysfunction. The knowledge of these early mechanisms is of seminal importance to support the research on reliable biomarkers to precociously identify the disease and possible disease-modifying therapies targeting α-syn. In this review, we will discuss these critical issues, providing a state of the art of the role of this protein in early PD and other synucleinopathies.
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- 2023
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41. ASO Visual Abstract: Routine Use of a Standardized, Mastectomy Diagram by Surgeons Improves Accuracy and Timeliness of the Final Pathological Report
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Seto, Andrew, Pass, Alexandra, Babkowski, Robert, Volpicelli, Elgida R., Cheng, Zandra, and Pass, Helen A.
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- 2023
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42. Is There a Burnout Epidemic among Medical Students? Results from a Systematic Review
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Matteo Di Vincenzo, Eleonora Arsenio, Bianca Della Rocca, Anna Rosa, Lucia Tretola, Rita Toricco, Alessia Boiano, Pierluigi Catapano, Sandra Cavaliere, Antonio Volpicelli, Gaia Sampogna, and Andrea Fiorillo
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medical students ,burnout ,prevention ,severe mental disorder ,mental exhaustion ,Medicine (General) ,R5-920 - Abstract
Background and Objectives: Medical students represent the ideal target group for promoting mental health and mental wellbeing, being exposed to specific risk factors, such as the content of medical training, the exposure to sickness and death, and a stressful academic routine. Medical students report high levels of cynicism and emotional exhaustion, which represent two of the essential features of burnout syndrome. In this systematic review, studies assessing the levels of burnout among medical students through validated tools worldwide were analyzed. Materials and Methods: A systematic review has been performed in order to identify studies: (1) focusing on samples of medical students; (2) evaluating burnout syndrome using validated tools; (3) providing prevalence data on burnout; and (4) written in English. Results: Out of the 5547 papers initially obtained, 64 were finally included in the analysis. The sample sizes ranged from 51 to 2682 participants. Almost all studies had a cross-sectional design; the Maslach Burnout Inventory and its related versions were the most frequently used assessment tools. The prevalence of burnout, which was stratified based on gender and academic stage, ranged from 5.6 to 88%. Burnout was mostly predicted by thoughts of stopping medical education, negative life events, lack of support, dissatisfaction, and poor motivation. Conclusions: The prevalence of burnout syndrome in medical students is quite heterogeneous, reaching a peak of 88% in some countries. However, several predictors have been identified, including negative life events or poor motivation. These findings highlight the need to develop preventive interventions targeting the future generation of medical doctors, in order to improve their coping strategies and resilience styles.
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- 2024
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43. Pediatric Hemangiomas in the Female Genital Tract: A Literature Review
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Lucia Merlino, Agnese Immacolata Volpicelli, Franco Anglana, Giulia D’Ovidio, Mattia Dominoni, Marianna Francesca Pasquali, Barbara Gardella, Paolo Inghirami, Pietro Lippa, and Roberto Senatori
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pediatric hemangioma ,vaginal hemangioma ,vulvar hemangioma ,hemangioma of lower genital tract ,Medicine - Abstract
Background: Hemangiomas are aberrant proliferations of blood vessels and the most frequent benign pediatric soft tissue tumors. Although they are common, genital localization is rare. This study aimed to assist doctors in the diagnosis, management, and treatment of pediatric vulvovaginal hemangiomas by conducting a review of the literature. Methods: We conducted a literature review including papers published between August 2009 and May 2023. Results: While most hemangiomas are usually indolent and resolve with time, in some cases, especially cervicovaginal and uterine ones, they might present with severe symptoms like heavy bleeding and need further instrumental investigation for diagnosis, like CT or MRI. As for the treatment, many options are available, with medical therapy or expectant management being the first choice. Conclusions: Vulvovaginal pediatric hemangiomas are rare and require more research on how to detect and manage these lesions, especially the symptomatic and the psychologically impacting ones. For the time being, treatment should be personalized based on the patient’s situation and clinician’s expertise.
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- 2024
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44. Parkinson's disease pathology is directly correlated to SIRT3 in human subjects and animal models: Implications for AAV.SIRT3-myc as a disease-modifying therapy
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Dennison Trinh, Ahmad R. Israwi, Harsimar Brar, Jose E.A. Villafuerte, Ruella Laylo, Humaiyra Patel, Sabika Jafri, Lina Al Halabi, Shaumia Sinnathurai, Kiran Reehal, Alyssa Shi, Vayisnavei Gnanamanogaran, Natalie Garabedian, Ivy Pham, Drake Thrasher, Philippe P. Monnier, Laura A. Volpicelli-Daley, and Joanne E. Nash
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Parkinson's disease ,α-synuclein pre-formed fibrils ,Rat model ,Disease-modifying ,Sirtuin 3 ,Mitochondria ,Neurosciences. Biological psychiatry. Neuropsychiatry ,RC321-571 - Abstract
In Parkinson's disease (PD), post-mortem studies in affected brain regions have demonstrated a decline in mitochondrial number and function. This combined with many studies in cell and animal models suggest that mitochondrial dysfunction is central to PD pathology. We and others have shown that the mitochondrial protein deacetylase, SIRT3, has neurorestorative effects in PD models. In this study, to determine whether there is a link between PD pathology and SIRT3, we analysed SIRT3 levels in human subjects with PD, and compared to age-matched controls. In the SNc of PD subjects, SIRT3 was reduced by 56.8 ± 15.5% compared to control, regardless of age (p
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- 2023
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45. What influences psychological functioning in patients with mood disorders? The role of clinical, sociodemographic, and temperamental characteristics in a naturalistic study
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Matteo Di Vincenzo, Gaia Sampogna, Bianca Della Rocca, Carlotta Brandi, Emiliana Mancuso, Lorenzo Landolfi, Antonio Volpicelli, Arcangelo Di Cerbo, Andrea Fiorillo, and Mario Luciano
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Functioning ,psychological ,Bipolar disorder ,Depression ,Quality of life ,Affective temperaments ,Psychiatry ,RC435-571 - Abstract
Abstract Background The present study aims to assess clinical and psychological correlates of psychological functioning in patients with mood disorders, in a naturalistic setting. In particular, we aimed to describe which sociodemographic, clinical, and temperamental dispositions are more frequently associated with poor psychological functioning, and to describe the association between cognitive and psychological functioning in euthymic patients with major depression and bipolar disorder. Methods Inclusion criteria were as follows: (1) diagnosis of major depression, or bipolar disorder type I or II; (2) age between 18 and 65 years; and (3) being in a stable phase of the disorder. Patients’ psychiatric symptoms, quality of life, affective temperaments, and impulsivity were investigated with validated assessment instruments. Results 166 patients have been recruited, mainly female (55.4%), whose mean age was 47.1 ± 14.2 years. 42.6% of individuals reported a diagnosis of major depression. According to regression analyses, poor cognitive performance (p
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- 2022
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46. The ChoCO-W prospective observational global study: Does COVID-19 increase gangrenous cholecystitis?
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Belinda De Simone, Fikri M. Abu-Zidan, Elie Chouillard, Salomone Di Saverio, Massimo Sartelli, Mauro Podda, Carlos Augusto Gomes, Ernest E. Moore, Susan J. Moug, Luca Ansaloni, Yoram Kluger, Federico Coccolini, Aitor Landaluce-Olavarria, Begoña Estraviz-Mateos, Ana Uriguen-Etxeberria, Alessio Giordano, Alfonso Palmieri Luna, Luz Adriana Hernández Amín, Adriana María Palmieri Hernández, Amanda Shabana, Zakaria Andee Dzulkarnaen, Muhammad Asyraf Othman, Mohamad Ikhwan Sani, Andrea Balla, Rosa Scaramuzzo, Pasquale Lepiane, Andrea Bottari, Fabio Staderini, Fabio Cianchi, Andrea Cavallaro, Antonio Zanghì, Alessandro Cappellani, Roberto Campagnacci, Angela Maurizi, Mario Martinotti, Annamaria Ruggieri, Asri Che Jusoh, Karim Abdul Rahman, Anis Suraya M. Zulkifli, Barbara Petronio, Belén Matías-García, Ana Quiroga-Valcárcel, Fernando Mendoza-Moreno, Boyko Atanasov, Fabio Cesare Campanile, Ilaria Vecchioni, Luca Cardinali, Grazia Travaglini, Elisa Sebastiani, Serge Chooklin, Serhii Chuklin, Pasquale Cianci, Enrico Restini, Sabino Capuzzolo, Giuseppe Currò, Rosalinda Filippo, Michele Rispoli, Daniel Aparicio-Sánchez, Virginia Durán Muñóz-Cruzado, Sandra Dios Barbeito, Samir Delibegovic, Amar Kesetovic, Diego Sasia, Felice Borghi, Giorgio Giraudo, Diego Visconti, Emanuele Doria, Mauro Santarelli, Davide Luppi, Stefano Bonilauri, Ugo Grossi, Giacomo Zanus, Alberto Sartori, Giacomo Piatto, Maurizio De Luca, Domenico Vita, Luigi Conti, Patrizio Capelli, Gaetano Maria Cattaneo, Athanasios Marinis, Styliani-Aikaterini Vederaki, Mehmet Bayrak, Yasemin Altıntas, Mustafa Yener Uzunoglu, Iskender Eren Demirbas, Yuksel Altinel, Serhat Meric, Yunus Emre Aktimur, Derya Salim Uymaz, Nail Omarov, Ibrahim Azamat, Eftychios Lostoridis, Eleni-Aikaterini Nagorni, Antonio Pujante, Gabriele Anania, Cristina Bombardini, Francesco Bagolini, Emre Gonullu, Baris Mantoglu, Recayi Capoglu, Stefano Cappato, Elena Muzio, Elif Colak, Suleyman Polat, Zehra Alan Koylu, Fatih Altintoprak, Zülfü Bayhan, Emrah Akin, Enrico Andolfi, Sulce Rezart, Jae Il Kim, Sung Won Jung, Yong Chan Shin, Octavian Enciu, Elena Adelina Toma, Fabio Medas, Gian Luigi Canu, Federico Cappellacci, Fabrizio D’Acapito, Giorgio Ercolani, Leonardo Solaini, Francesco Roscio, Federico Clerici, Roberta Gelmini, Francesco Serra, Elena Giulia Rossi, Francesco Fleres, Guglielmo Clarizia, Alessandro Spolini, Francesco Ferrara, Gabriela Nita, Jlenia Sarnari, Mahir Gachabayov, Abakar Abdullaev, Gaetano Poillucci, Gian Marco Palini, Simone Veneroni, Gianluca Garulli, Micaela Piccoli, Gianmaria Casoni Pattacini, Francesca Pecchini, Giulio Argenio, Mariano Fortunato Armellino, Giuseppe Brisinda, Silvia Tedesco, Pietro Fransvea, Giuseppe Ietto, Caterina Franchi, Giulio Carcano, Gennaro Martines, Giuseppe Trigiante, Giulia Negro, Gustavo Machain Vega, Agustín Rodríguez González, Leonardo Ojeda, Gaetano Piccolo, Andrea Bondurri, Anna Maffioli, Claudio Guerci, Boo Han Sin, Zamri Zuhdi, Azlanudin Azman, Hussam Mousa, Shadi al Bahri, Goran Augustin, Ivan Romic, Trpimir Moric, Ioannis Nikolopoulos, Jacopo Andreuccetti, Giusto Pignata, Rossella D’Alessio, Jakub Kenig, Urszula Skorus, Gustavo Pereira Fraga, Elcio Shiyoiti Hirano, Jackson Vinícius de Lima Bertuol, Arda Isik, Eray Kurnaz, Mohammad Sohail Asghar, Ameer Afzal, Ali Akbar, Taxiarchis Konstantinos Nikolouzakis, Konstantinos Lasithiotakis, Emmanuel Chrysos, Koray Das, Nazmi Özer, Ahmet Seker, Mohamed Ibrahim, Hytham K. S. Hamid, Ahmed Babiker, Konstantinos Bouliaris, George Koukoulis, Chrysoula-Christina Kolla, Andrea Lucchi, Laura Agostinelli, Antonio Taddei, Laura Fortuna, Carlotta Agostini, Leo Licari, Simona Viola, Cosimo Callari, Letizia Laface, Emmanuele Abate, Massimiliano Casati, Alessandro Anastasi, Giuseppe Canonico, Linda Gabellini, Lorenzo Tosi, Anna Guariniello, Federico Zanzi, Lovenish Bains, Larysa Sydorchuk, Oksana Iftoda, Andrii Sydorchuk, Michele Malerba, Federico Costanzo, Raffaele Galleano, Michela Monteleone, Andrea Costanzi, Carlo Riva, Maciej Walędziak, Andrzej Kwiatkowski, Łukasz Czyżykowski, Piotr Major, Marcin Strzałka, Maciej Matyja, Michal Natkaniec, Maria Rosaria Valenti, Maria Domenica Pia Di Vita, Maria Sotiropoulou, Stylianos Kapiris, Damien Massalou, Massimiliano Veroux, Alessio Volpicelli, Rossella Gioco, Matteo Uccelli, Marta Bonaldi, Stefano Olmi, Matteo Nardi, Giada Livadoti, Cristian Mesina, Theodor Viorel Dumitrescu, Mihai Calin Ciorbagiu, Michele Ammendola, Giorgio Ammerata, Roberto Romano, Mihail Slavchev, Evangelos P. Misiakos, Emmanouil Pikoulis, Dimitrios Papaconstantinou, Mohamed Elbahnasawy, Sherief Abdel-elsalam, Daniel M. Felsenreich, Julia Jedamzik, Nikolaos V. Michalopoulos, Theodoros A. Sidiropoulos, Maria Papadoliopoulou, Nicola Cillara, Antonello Deserra, Alessandro Cannavera, Ionuţ Negoi, Dimitrios Schizas, Athanasios Syllaios, Ilias Vagios, Stavros Gourgiotis, Nick Dai, Rekha Gurung, Marcus Norrey, Antonio Pesce, Carlo Vittorio Feo, Nicolo’ Fabbri, Nikolaos Machairas, Panagiotis Dorovinis, Myrto D. Keramida, Francesk Mulita, Georgios Ioannis Verras, Michail Vailas, Omer Yalkin, Nidal Iflazoglu, Direnc Yigit, Oussama Baraket, Karim Ayed, Mohamed hedi Ghalloussi, Parmenion Patias, Georgios Ntokos, Razrim Rahim, Miklosh Bala, Asaf Kedar, Robert G. Sawyer, Anna Trinh, Kelsey Miller, Ruslan Sydorchuk, Ruslan Knut, Oleksandr Plehutsa, Rumeysa Kevser Liman, Zeynep Ozkan, Saleh Abdel Kader, Sanjay Gupta, Monika Gureh, Sara Saeidi, Mohsen Aliakbarian, Amin Dalili, Tomohisa Shoko, Mitsuaki Kojima, Raira Nakamoto, Semra Demirli Atici, Gizem Kilinc Tuncer, Tayfun Kaya, Spiros G. Delis, Stefano Rossi, Biagio Picardi, Simone Rossi del Monte, Tania Triantafyllou, Dimitrios Theodorou, Tadeja Pintar, Jure Salobir, Dimitrios K. Manatakis, Nikolaos Tasis, Vasileios Acheimastos, Orestis Ioannidis, Lydia Loutzidou, Savvas Symeonidis, Tiago Correia de Sá, Mónica Rocha, Tommaso Guagni, Desiré Pantalone, Gherardo Maltinti, Vladimir Khokha, Wafaa Abdel-elsalam, Basma Ghoneim, José Antonio López-Ruiz, Yasin Kara, Syaza Zainudin, Firdaus Hayati, Nornazirah Azizan, Victoria Tan Phooi Khei, Rebecca Choy Xin Yi, Harivinthan Sellappan, Zaza Demetrashvili, Nika Lekiashvili, Ana Tvaladze, Caterina Froiio, Daniele Bernardi, Luigi Bonavina, Angeles Gil-Olarte, Sebastiano Grassia, Estela Romero-Vargas, Francesco Bianco, Andrew A. Gumbs, Agron Dogjani, Ferdinando Agresta, Andrey Litvin, Zsolt J. Balogh, George Gendrikson, Costanza Martino, Dimitrios Damaskos, Nikolaos Pararas, Andrew Kirkpatrick, Mikhail Kurtenkov, Felipe Couto Gomes, Adolfo Pisanu, Oreste Nardello, Fabrizio Gambarini, Hager Aref, Nicola de’ Angelis, Vanni Agnoletti, Antonio Biondi, Marco Vacante, Giulia Griggio, Roberta Tutino, Marco Massani, Giovanni Bisetto, Savino Occhionorelli, Dario Andreotti, Domenico Lacavalla, Walter L. Biffl, and Fausto Catena
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Acute cholecystitis ,Cholecystectomy ,Gangrene ,COVID-19 ,SARS-CoV-2 ,Laparoscopy ,Surgery ,RD1-811 ,Medical emergencies. Critical care. Intensive care. First aid ,RC86-88.9 - Abstract
Abstract Background The incidence of the highly morbid and potentially lethal gangrenous cholecystitis was reportedly increased during the COVID-19 pandemic. The aim of the ChoCO-W study was to compare the clinical findings and outcomes of acute cholecystitis in patients who had COVID-19 disease with those who did not. Methods Data were prospectively collected over 6 months (October 1, 2020, to April 30, 2021) with 1-month follow-up. In October 2020, Delta variant of SARS CoV-2 was isolated for the first time. Demographic and clinical data were analyzed and reported according to the STROBE guidelines. Baseline characteristics and clinical outcomes of patients who had COVID-19 were compared with those who did not. Results A total of 2893 patients, from 42 countries, 218 centers, involved, with a median age of 61.3 (SD: 17.39) years were prospectively enrolled in this study; 1481 (51%) patients were males. One hundred and eighty (6.9%) patients were COVID-19 positive, while 2412 (93.1%) were negative. Concomitant preexisting diseases including cardiovascular diseases (p
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- 2022
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47. Clinical course of Coronavirus Disease-19 in patients with haematological malignancies is characterized by a longer time to respiratory deterioration compared to non-haematological ones: results from a case–control study
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Oliva, A., Curtolo, A., Volpicelli, L., Cancelli, F., Borrazzo, C., Cogliati Dezza, F., Marcelli, G., Gavaruzzi, F., Di Bari, S., Ricci, P., Turriziani, O., Mastroianni, C. M., and Venditti, M.
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- 2022
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48. Retrospective analysis of the diagnostic accuracy of lung ultrasound for pulmonary embolism in patients with and without pleuritic chest pain
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Peiman Nazerian, Chiara Gigli, Angelika Reissig, Emanuele Pivetta, Simone Vanni, Thomas Fraccalini, Giordana Ferraris, Alessandra Ricciardolo, Stefano Grifoni, Giovanni Volpicelli, and WINFOCUS and US SIMEU study group
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Pulmonary embolism ,Lung ultrasound ,Pleuritic pain ,Diagnostic accuracy ,Medical physics. Medical radiology. Nuclear medicine ,R895-920 - Abstract
Abstract Background Lung ultrasound (LUS) has a role in the diagnosis of pulmonary embolism (PE) mainly based on the visualization of pulmonary infarctions. However, examining the whole chest to detect small peripheral infarctions by LUS may be challenging. Pleuritic pain, a frequent presenting symptom in patients with PE, is usually localized in a restricted chest area identified by the patient itself. Our hypothesis is that sensitivity of LUS for PE in patients with pleuritic chest pain may be higher due to the possibility of focusing the examination in the painful area. We combined data from three prospective studies on LUS in patients suspected of PE and extracted data regarding patients with and without pleuritic pain at presentation to compare the performances of LUS. Results Out of 872 patients suspected of PE, 217 (24.9%) presented with pleuritic pain and 279 patients (32%) were diagnosed with PE. Pooled sensitivity of LUS for PE in patients with and without pleuritic chest pain was 81.5% (95% CI 70–90.1%) and 49.5% (95% CI 42.7–56.4%) (p
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- 2022
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49. Alpha-synuclein in Parkinson’s disease and other synucleinopathies: from overt neurodegeneration back to early synaptic dysfunction
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Calabresi, Paolo, Mechelli, Alessandro, Natale, Giuseppina, Volpicelli-Daley, Laura, Di Lazzaro, Giulia, and Ghiglieri, Veronica
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- 2023
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50. On a Class of Nonlinear Elliptic Equations with General Growth in the Gradient
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M. Francesca Betta, Anna Mercaldo, and Roberta Volpicelli
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existence ,uniqueness ,nonlinear elliptic equations ,fixed point ,Mathematics ,QA1-939 - Abstract
In this paper, we prove an existence and uniqueness result for a class of Dirichlet boundary value problems whose model is −Δpu=β|∇u|q+c|u|p−2u+fin Ω,u=0on ∂Ω, where Ω is an open bounded subset of RN, N≥2, 1
- Published
- 2024
- Full Text
- View/download PDF
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