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The functions of the adrenal cortex, thyroid gland and carbohydrate metabolism have been analysed in 20 patients to whom current schemes of premedication and anesthesia have been applied, 20 patients who in the nearest preoperative period and intraoperatively have been administered ganglioblockers and adrenolytics, and 20 patients in whom clophelin has been used during premedication and anesthesia. It has been established that the use of stress-protecting agents for premedication and anesthesia almost prevents hyperergic reaction of the adrenal cortex, thyroid gland and carbohydrate metabolism.

The indices of central and peripheral hemodynamics in 40 patients with the generally accepted scheme of premedication and in 40 patients who were given adrenogangliolytics for medicamentous preparing before narcosis have been analyzed. The inclusion of these drugs in the premedication preparing was established to ensure a sufficiently complete prevention of an excessive preoperative stress reaction.

Central and peripheral hemodynamic changes have been studied in 80 patients aged 18 to 67 years after planned gastro-intestinal and biliary surgery. In 40 of them clopheline (clonidine) was used in premedication. The use of clopheline in premedication led to stabilization of central hemodynamic parameters, made it possible to improve considerably microcirculation, avoid the unfavourable effects of psychic tension, induction to anesthesia, laryngoscopy and tracheal intubation. All the above permits the authors to recommend the use of clopheline in premedication.