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10. Motor abilities in adults born with very low birthweight: A study of two birth cohorts from Finland and Norway.

Author

Benum, Silje D., Aakvik, Kristina A. D., Jørgensen, Anna P. M., Jussinniemi, Laura, Kulmala, Maarit, Vollsæter, Maria, Kajantie, Eero, and Evensen, Kari Anne I.

Abstract

Aim: To compare overall, fine, and gross motor abilities in adults born preterm with very low birthweight (VLBW) and a control group of term‐born individuals. Method: In a joint assessment of the Helsinki Study of Very Low Birth Weight Adults and NTNU Low Birth Weight in a Lifetime Perspective study, data were collected with harmonized methods for 118 adults born preterm (gestational age < 37 weeks) with VLBW (≤1500 g) and 147 control individuals. The primary outcome was overall motor abilities; secondary outcomes were fine and gross motor abilities. Results: The Bruininks Motor Ability Test Short Form total score was 4.1 (95% confidence interval 2.7–6.0) points lower in adults born with VLBW than in the control group, adjusted for cohort, age, and sex. This was partly mediated by their shorter height. They also had lower scores for other fine and gross motor tests. Results were similar when participants with neurosensory impairment were excluded, and when we adjusted for additional covariates. Interpretation: Adults born preterm with VLBW had poorer overall, fine, and gross motor abilities than adults born at term. This indicates that substantial difficulties in motor function among individuals born preterm with VLBW persist into mid‐adulthood. [ABSTRACT FROM AUTHOR]

Published
2024
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11. Laryngeal response to high-intensity exercise in healthy athletes

Author

Carlsen, Petter Helø, primary, Muralitharan, Praveen, additional, Fenne, Hilde, additional, Hammer, Ida Jansrud, additional, Engan, Mette, additional, Vollsæter, Maria, additional, Bovim, Lars Peder, additional, Røksund, Ola Drange, additional, Halvorsen, Thomas, additional, and Clemm, Hege Havstad, additional

Published
2024
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15. Health-related quality of life in two birth cohorts of extremely preterm born adults.

Author

Benestad, Merete Røineland, Drageset, Jorunn, Vollsæter, Maria, Hufthammer, Karl Ove, Halvorsen, Thomas, and Vederhus, Bente Johanne

Subjects
QUALITY of life, COHORT analysis, ADULTS, NEONATOLOGY, CHILDREN'S health
Abstract

Aim: Investigate potential long- term cohort influences on health-related quality of life (HRQoL) in adults born extremely preterm (EP) during the 1980-90s, in view of advancements in neonatal care within that timeframe. Methods: Two cohorts of EP-born adults (82-85 cohort and 91-92 cohort) enrolling matched term controls, were compared. Participants were assessed at 18 years and again in their mid-twenties using the Child Health Questionnaire Children Form- 87 (CHQ-CF87) and the Short Form Health Survey (SF-36). Results: At 18 years, 77 (90%) EP- born and 75 (93%) term controls had data, followed by 67 (78%) EP-born and 66 (82%) term controls in their mid-twenties. At 18 years, there were no differences across the birth decades, and EP-born and term-born reported relatively similar HRQoL scores. In the mid- twenties, birth decade did also not significantly impact HRQoL scores, although the EP--born 82-85 cohort scored numerically poorer than the 91-92 cohort in three domains. Term controls scored similarly across birth decade in all domains. Regarding influence from neonatal factors, postnatal corticosteroids had a negative impact in some domains. Conclusion: No significant differences in HRQoL were observed between EP-born adults from the 82-85 cohort versus the 91-92 cohort, although the EP- born 82-85 cohort tended to score poorer in their mid-twenties. [ABSTRACT FROM AUTHOR]

Published
2024
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16. Expiratory airflow in late adolescence and early adulthood in individuals born very preterm or with very low birthweight compared with controls born at term or with normal birthweight: a meta-analysis of individual participant data

Author

Doyle, Lex W, Andersson, Sture, Bush, Andy, Cheong, Jeanie L Y, Clemm, Hege, Evensen, Kari Anne I, Gough, Aisling, Halvorsen, Thomas, Hovi, Petteri, Kajantie, Eero, Lee, Katherine J, McGarvey, Lorcan, Narang, Indra, Näsänen-Gilmore, Pieta, Steinshamn, Sigurd, Vollsaeter, Maria, and Vrijlandt, Elianne J L E

Published
2019
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34. Long-term consequences of low birth weight - Motor function as a determinant of physical activity, fitness and body composition in very low birth weight adults: An international study

Author

Evensen, Kari, Benum, Silje, Mork, Paul, Morken, Tora, Lydersen, Stian, Indredavik, Marit, Brubakk, Ann-Mari, Halvorsen, Thomas, Vollsæter, Maria, Kajantie, Eero, Tikanmäki, Marjaana, Hovi, Petteri, Nurhonen, Markku, Majander, Anna, Baumann, Nicole, and Cheong, Jeanie

Subjects
Physical activity, Preterm, Visual function, Medicine and Health Sciences, Motor skills, Motor abilities, Very low birth weight, Overweight, Body composition, Motor function
Abstract

Every year, approximately 15 million infants worldwide (11% of all newborns) are born preterm (

Published
2022
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36. Maternal education and cognitive development in 15 European very-preterm birth cohorts from the RECAP Preterm platform

Author

Sentenac, Mariane, Benhammou, Valérie, Aden, Ulrika, Ancel, Pierre Yves, Bakker, Leonhard A., Bakoy, Hannah, Barros, Henrique, Baumann, Nicole, Bilsteen, Josephine Funck, Børch, Klaus, Croci, Ileana, Cuttini, Marina, Draper, Elizabeth, Halvorsen, Thomas, Johnson, Samantha, Källén, Karin, Land, Tuuli, Lebeer, Jo, Lehtonen, Liisa, Maier, Rolf F., Marlow, Neil, Morgan, Andrei, Ni, Yanyan, Raikkonen, Katri, Rtimi, Anass, Sarrechia, Iemke, Varendi, Heili, Vollsaeter, Maria, Wolke, Dieter, Ylijoki, Milla, Zeitlin, Jennifer, Sentenac, Mariane, Benhammou, Valérie, Aden, Ulrika, Ancel, Pierre Yves, Bakker, Leonhard A., Bakoy, Hannah, Barros, Henrique, Baumann, Nicole, Bilsteen, Josephine Funck, Børch, Klaus, Croci, Ileana, Cuttini, Marina, Draper, Elizabeth, Halvorsen, Thomas, Johnson, Samantha, Källén, Karin, Land, Tuuli, Lebeer, Jo, Lehtonen, Liisa, Maier, Rolf F., Marlow, Neil, Morgan, Andrei, Ni, Yanyan, Raikkonen, Katri, Rtimi, Anass, Sarrechia, Iemke, Varendi, Heili, Vollsaeter, Maria, Wolke, Dieter, Ylijoki, Milla, and Zeitlin, Jennifer

Abstract

BACKGROUND: Studies are sparse and inconclusive about the association between maternal education and cognitive development among children born very preterm (VPT). Although this association is well established in the general population, questions remain about its magnitude among children born VPT whose risks of medical and developmental complications are high. We investigated the association of maternal education with cognitive outcomes in European VPT birth cohorts. METHODS: We used harmonized aggregated data from 15 population-based cohorts of children born at <32 weeks of gestational age (GA) or <1500 g from 1985 to 2013 in 13 countries with information on maternal education and assessments of general development at 2-3 years and/or intelligence quotients between 4 and 15 years. Term-born controls (≥37 weeks of GA) were available in eight cohorts. Maternal education was classified as: low (primary/lower secondary); medium (upper secondary/short tertiary); high (bachelor's/higher). Pooled standardized mean differences (SMDs) in cognitive scores were estimated (reference: high educational level) for children assessed at ages 2-3, 4-7 and 8-15 years. RESULTS: The study included 10 145 VPT children from 12 cohorts at 2-3 years, 8829 from 12 cohorts at 4-7 years and 1865 children from 6 cohorts at 8-15 years. Children whose mothers had low, compared with high, educational attainment scored lower on cognitive measures [pooled unadjusted SMDs: 2-3 years = -0.32 (95% confidence intervals: -0.43 to -0.21); 4-7 years = -0.57 (-0.67; -0.47); 8-15 years = -0.54 (-0.72; -0.37)]. Analyses by GA subgroups (<27 vs ≥27 weeks) in children without severe neonatal morbidity and term controls yielded similar results. CONCLUSIONS: Across diverse settings and regardless of the degree of prematurity, low maternal education was associated with lower cognition.

Published
2022

42. Exercise Training in Duchenne Muscular Dystrophy: A Systematic Review and Meta-Analysis

Author

Hammer, Stian, Toussaint, Michel, Vollsæter, Maria, Tvedt, Marianne Nesbjørg, Røksund, Ola Drange, Reychler, Gregory, Lund, Hans, and Andersen, Tiina Maarit

Subjects
Duchenne muscular dystrophy, respiratory muscle training, education, Physical Therapy, Sports Therapy and Rehabilitation, General Medicine, RM1-950, rehabilitation, Muscular Dystrophy, Duchenne, Quality of Life, Humans, Muscle Strength, Therapeutics. Pharmacology, Exercise, exercise training, physiotherapy
Abstract

Objective: To evaluate the effects and safety of exercise training, and to determine the most effective exercise intervention for people with Duchenne muscular dystrophy. Exercise training was compared with no training, placebo or alternative exercise training. Primary outcomes were functioning and health-related quality of life. Secondary outcomes were muscular strength, endurance and lung function. Data sources: A systematic literature search was conducted in Medline, EMBASE, CINAHL, Cochrane Central, PEDro and Scopus. Study selection and data extraction: Screening, data extraction, risk of bias and quality assessment were carried out. Risk of bias was assessed using the Cochrane Collaborations risk of bias tools. The certainty of evidence was assessed using Grading of Recommendations Assessment, Development and Evaluation. Data synthesis: Twelve studies with 282 participants were included. A narrative synthesis showed limited or no improvements in functioning compared with controls. Health-related quality of life was assessed in only 1 study. A meta-analysis showed a significant difference in muscular strength and endurance in favour of exercise training compared with no training and placebo. However, the certainty of evidence was very low. Conclusion: Exercise training may be beneficial in Duchenne muscular dystrophy, but the evidence remains uncertain. Further research is needed on exercise training to promote functioning and health-related quality of life in Duchenne muscular dystrophy. Lay abstract The aim of this study was to examine the effects of all types of exercise training compared with no training, placebo or alternative exercise training programmes in people with Duchenne muscular dystrophy. The primary outcomes were functioning and health-related quality of life. Secondary outcomes were muscular strength and endurance. A further aim was to evaluate safety and, if possible, to find the most effective exercise training intervention. This review investigates existing research on this topic. The results have been systematically gathered and analysed, to give a broader view of what effect exercise training may have for people with Duchenne muscular dystrophy. The results suggest that exercise training preserves functioning, and benefits muscular strength and endurance. The study was not able to identify the best type of exercise training and prescriptions to use in Duchenne muscular dystrophy. The validity of the results was reduced by the low number of studies included, the low quality of the studies, and diversity in both the interventions and outcome measures used. The results should therefore be interpreted with caution.

Published
2022

44. Left Vocal Cord Paralysis, Lung Function and Exercise Capacity in Young Adults Born Extremely Preterm With a History of Neonatal Patent Ductus Arteriosus Surgery—A National Cohort Study

Author

Engan, Mette, primary, Engeset, Merete S., additional, Sandvik, Lorentz, additional, Gamlemshaug, Ole C. O., additional, Engesæter, Ingvild Ø., additional, Øymar, Knut, additional, Vollsæter, Maria, additional, Røksund, Ola D., additional, Hufthammer, Karl Ove, additional, Halvorsen, Thomas, additional, and Clemm, Hege H., additional

Published
2022
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