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21 results on '"Vollmer, Laura L."'

4. Data from A Simplified Synthesis of Novel Dictyostatin Analogues with In Vitro Activity against Epothilone B–Resistant Cells and Antiangiogenic Activity in Zebrafish Embryos

Author

Vollmer, Laura L., primary, Jiménez, Maria, primary, Camarco, Daniel P., primary, Zhu, Wei, primary, Daghestani, Hikmat N., primary, Balachandran, Raghavan, primary, Reese, Celeste E., primary, Lazo, John S., primary, Hukriede, Neil A., primary, Curran, Dennis P., primary, Day, Billy W., primary, and Vogt, Andreas, primary

Published
2023
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5. Supplementary Tables 1-2,Characterization Data & References from A Simplified Synthesis of Novel Dictyostatin Analogues with In Vitro Activity against Epothilone B–Resistant Cells and Antiangiogenic Activity in Zebrafish Embryos

Author

Vollmer, Laura L., primary, Jiménez, Maria, primary, Camarco, Daniel P., primary, Zhu, Wei, primary, Daghestani, Hikmat N., primary, Balachandran, Raghavan, primary, Reese, Celeste E., primary, Lazo, John S., primary, Hukriede, Neil A., primary, Curran, Dennis P., primary, Day, Billy W., primary, and Vogt, Andreas, primary

Published
2023
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6. NMR Spectra from A Simplified Synthesis of Novel Dictyostatin Analogues with In Vitro Activity against Epothilone B–Resistant Cells and Antiangiogenic Activity in Zebrafish Embryos

Author

Vollmer, Laura L., primary, Jiménez, Maria, primary, Camarco, Daniel P., primary, Zhu, Wei, primary, Daghestani, Hikmat N., primary, Balachandran, Raghavan, primary, Reese, Celeste E., primary, Lazo, John S., primary, Hukriede, Neil A., primary, Curran, Dennis P., primary, Day, Billy W., primary, and Vogt, Andreas, primary

Published
2023
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7. N-(1′-naphthyl)-3,4,5-trimethoxybenzohydrazide as microtubule destabilizer: Synthesis, cytotoxicity, inhibition of cell migration and in vivo activity against acute lymphoblastic leukemia

Author

Salum, Lívia B., Mascarello, Alessandra, Canevarolo, Rafael R., Altei, Wanessa F., Laranjeira, Angelo B.A., Neuenfeldt, Patrícia D., Stumpf, Taisa R., Chiaradia-Delatorre, Louise D., Vollmer, Laura L., Daghestani, Hikmat N., de Souza Melo, Carolina P., Silveira, André B., Leal, Paulo C., Frederico, Marisa J.S., do Nascimento, Leandro F., Santos, Adair R.S., Andricopulo, Adriano D., Day, Billy W., Yunes, Rosendo A., Vogt, Andreas, Yunes, José A., and Nunes, Ricardo J.

Published
2015
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9. sj-pdf-1-jbx-10.1177_24725552211018198 – Supplemental material for A High-Content Screening Assay for Small Molecules That Stabilize Mutant Triose Phosphate Isomerase (TPI) as Treatments for TPI Deficiency

Author

Vogt, Andreas, Eicher, Samantha L., Myers, Tracey D., Hrizo, Stacy L., Vollmer, Laura L., Meyer, E. Michael, and Palladino, Michael J.

Subjects
FOS: Clinical medicine, 111599 Pharmacology and Pharmaceutical Sciences not elsewhere classified
Abstract

Supplemental material, sj-pdf-1-jbx-10.1177_24725552211018198 for A High-Content Screening Assay for Small Molecules That Stabilize Mutant Triose Phosphate Isomerase (TPI) as Treatments for TPI Deficiency by Andreas Vogt, Samantha L. Eicher, Tracey D. Myers, Stacy L. Hrizo, Laura L. Vollmer, E. Michael Meyer and Michael J. Palladino in SLAS Discovery

Published
2021
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10. LMNB1_Assay_Development_paper_REV2_Supplemental – Supplemental material for Development and Optimization of a High-Content Analysis Platform to Identify Suppressors of Lamin B1 Overexpression as a Therapeutic Strategy for Autosomal Dominant Leukodystrophy

Author

Nmezi, Bruce, Vollmer, Laura L., Shun, Tong Ying, Gough, Albert, Harshvardhan Rolyan, Liu, Fang, Yumeng Jia, Quasar S. Padiath, and Vogt, Andreas

Subjects
FOS: Clinical medicine, 111599 Pharmacology and Pharmaceutical Sciences not elsewhere classified
Abstract

Supplemental material, LMNB1_Assay_Development_paper_REV2_Supplemental for Development and Optimization of a High-Content Analysis Platform to Identify Suppressors of Lamin B1 Overexpression as a Therapeutic Strategy for Autosomal Dominant Leukodystrophy by Bruce Nmezi, Laura L. Vollmer, Tong Ying Shun, Albert Gough, Harshvardhan Rolyan, Fang Liu, Yumeng Jia, Quasar S. Padiath and Andreas Vogt in SLAS Discovery

Published
2020
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11. A Tumor Cell-Selective Inhibitor of Mitogen-Activated Protein Kinase Phosphatases Sensitizes Breast Cancer Cells to Lymphokine-Activated Killer Cell Activity

Author

Kaltenmeier, Christof T., primary, Vollmer, Laura L., additional, Vernetti, Lawrence A., additional, Caprio, Lindsay, additional, Davis, Keanu, additional, Korotchenko, Vasiliy N., additional, Day, Billy W., additional, Tsang, Michael, additional, Hulkower, Keren I., additional, Lotze, Michael T., additional, and Vogt, Andreas, additional

Published
2017
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12. A High-Content Screen Reveals New Small-Molecule Enhancers of Ras/Mapk Signaling as Probes for Zebrafish Heart Development.

Author

Saydmohammed, Manush, Vollmer, Laura L., Onuoha, Ezenwa O., Maskrey, Taber S., Gibson, Gregory, Watkins, Simon C., Wipf, Peter, Vogt, Andreas, and Tsang, Michael

Abstract

Zebrafish is the preferred vertebrate model for high throughput chemical screens to discover modulators of complex biological pathways. We adapted a transgenic zebrafish line, Tg(dusp6:EGFP), which reports on fibroblast growth factor (Fgf)/Ras/Mapk activity, into a quantitative, high-content chemical screen to identify novel Fgf hyperactivators as chemical probes for zebrafish heart development and regeneration. We screened 10,000 compounds from the TimTec ActiProbe library, and identified several structurally distinct classes of molecules that enhanced Fgf/Ras/Mapk signaling. We chose three agents—ST020101, ST011282, and ST006994—for confirmatory and functional studies based on potency, repeatability with repurchased material, favorable whole organism toxicity, and evidence of structure–activity relationships. Functional follow-up assays confirmed that all three compounds induced the expression of Fgf target genes during zebrafish embryonic development. Moreover, these compounds increased cardiac progenitor populations by effecting a fate change from endothelial to cardiac progenitors that translated into increased numbers of cardiomyocytes. Interestingly, ST006994 augmented Fgf/Ras/Mapk signaling without increasing Erk phosphorylation, suggesting a molecular mechanism of action downstream of Erk. We posit that the ST006994 pharmacophore could become a unique chemical probe to uncover novel mechanisms of Fgf signaling during heart development and regeneration downstream of the Mapk signaling node. [ABSTRACT FROM AUTHOR]

Published
2018
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14. In Vivo Structure-Activity Relationship Studies Support Allosteric Targeting of a Dual Specificity Phosphatase

Author

Korotchenko, Vasiliy N., primary, Saydmohammed, Manush, additional, Vollmer, Laura L., additional, Bakan, Ahmet, additional, Sheetz, Kyle, additional, Debiec, Karl T., additional, Greene, Kristina A., additional, Agliori, Christine S., additional, Bahar, Ivet, additional, Day, Billy W., additional, Vogt, Andreas, additional, and Tsang, Michael, additional

Published
2014
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16. Survivin Is a Therapeutic Target in Merkel Cell Carcinoma

Author

Arora, Reety, primary, Shuda, Masahiro, additional, Guastafierro, Anna, additional, Feng, Huichen, additional, Toptan, Tuna, additional, Tolstov, Yanis, additional, Normolle, Daniel, additional, Vollmer, Laura L., additional, Vogt, Andreas, additional, Dömling, Alexander, additional, Brodsky, Jeffrey L., additional, Chang, Yuan, additional, and Moore, Patrick S., additional

Published
2012
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18. A Simplified Synthesis of Novel Dictyostatin Analogues with In Vitro Activity against Epothilone B–Resistant Cells and Antiangiogenic Activity in Zebrafish Embryos

Author

Vollmer, Laura L., primary, Jiménez, Maria, additional, Camarco, Daniel P., additional, Zhu, Wei, additional, Daghestani, Hikmat N., additional, Balachandran, Raghavan, additional, Reese, Celeste E., additional, Lazo, John S., additional, Hukriede, Neil A., additional, Curran, Dennis P., additional, Day, Billy W., additional, and Vogt, Andreas, additional

Published
2011
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21. Identifying a resistance determinant for the antimitotic natural products disorazole C1 and A1.

Author

Lazo, John S, Reese, Celeste E, Vogt, Andreas, Vollmer, Laura L, Kitchens, Carolyn A, Günther, Eckhard, Graham, Thomas H, Hopkins, Chad D, and Wipf, Peter

Abstract

Disorazoles are macrocyclic polyketides first isolated from the fermentation broth of the myxobacterium Sorangium cellulosum. Both the major fermentation product disorazole A(1) and its much rarer companion disorazole C(1) exhibit potent cytotoxic activity against many human tumor cells. Furthermore, the disorazoles appear to bind tubulin uniquely among known antimitotic agents, promoting apoptosis or premature senescence. It is uncertain what conveys tumor cell sensitivity to these complex natural products. Therefore, we generated and characterized human tumor cells resistant to disorazole C(1). Resistant cells proved exceedingly difficult to generate and required single step mutagenesis with chronic stepwise exposure to increasing concentrations of disorazole C(1). Compared with wild-type HeLa cells, disorazole C(1)-resistant HeLa/DZR cells were 34- and 8-fold resistant to disorazole C(1) and disorazole A(1) growth inhibition, respectively. HeLa/DZR cells were also remarkably cross-resistant to vinblastine (280-fold), paclitaxel (2400-fold), and doxorubicin (47-fold) but not cisplatin, suggesting a multidrug-resistant phenotype. Supporting this hypothesis, MCF7/MDR cells were 10-fold cross-resistant to disorazole C(1). HeLa/DZR disorazole resistance was not durable in the absence of chronic compound exposure. Verapamil reversed HeLa/DZR resistance to disorazole C(1) and disorazole A(1). Moreover, HeLa/DZR cells expressed elevated levels of the drug resistance ATP-binding cassette ABCB1 transporter. Loss of ABCB1 by incubation with short interfering RNA restored sensitivity to the disorazoles. Thus, the multidrug resistance transporter ABCB1 can affect the cytotoxicity of both disorazole C(1) and A(1). Disorazole C(1), however, retained activity against cells resistant against the clinically used microtubule-stabilizing agent epothilone B.

Published
2010
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