1. Body mass index and outcome after revascularization for symptomatic carotid artery stenosis
- Author
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Volkers, EJ, Greving, JP, Hendrikse, J, Algra, A, Kappelle, LJ, Becquemin, JP, Bonati, LH, Brott, TG, Bulbulia, R, Calvet, D, Eckstein, HH, Fraedrich, G, Gregson, J, Halliday, A, Howard, G, Jansen, O, Roubin, GS, Brown, MM, Mas, JL, Ringleb, PA, Carotid Stenosis Trialists' Collaboration, COLLABORATORS, Algra, AProf, Becquemin, JPProf, Mas, JLProf, Brown, MMProf, Hendrikse, JProf, Eckstein, HHProf, Fraedrich, GProf, Jansen, OProf, Ringleb, PAProf, Brott, TGProf, Howard, GProf, Roubin, GSProf, and Radcliffe, J
- Abstract
To determine whether the obesity paradox exists in patients who undergo carotid artery stenting (CAS) or carotid endarterectomy (CEA) for symptomatic carotid artery stenosis. We combined individual patient data from 2 randomized trials (Endarterectomy vs Angioplasty in Patients with Symptomatic Severe Carotid Stenosis and Stent-Protected Angioplasty vs Carotid Endarterectomy) and 3 centers in a third trial (International Carotid Stenting Study). Baseline body mass index (BMI) was available for 1,969 patients and classified into 4 groups: 120 days after randomization). This outcome was compared between different BMI strata in CAS and CEA patients separately, and in the total group. We performed intention-to-treat multivariable Cox regression analyses. Median follow-up was 2.0 years. Stroke or death occurred in 159 patients in the periprocedural (cumulative risk 8.1%) and in 270 patients in the postprocedural period (rate 4.8/100 person-years). BMI did not affect periprocedural risk of stroke or death for patients assigned to CAS (ptrend = 0.39) or CEA (ptrend = 0.77) or for the total group (ptrend = 0.48). Within the total group, patients with BMI 25
- Published
- 2017