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Background: Easily accessible health information on the internet can be a powerful tool to improve health care. However, much information on the internet is of poor quality and many patients feel unable to appraise its quality. Therefore, we developed the web portal tala-med providing evidence-based, [for full text, please go to the a.m. URL]

Hintergrund: Eine patientenorientierte Versorgung steht weltweit im Fokus des öffentlichen Gesundheitswesens. Angesichts der Komplexität ihrer Versorgungsbedürfnisse sind multimorbide ältere Patient*innen eine prioritäre Zielgruppe für eine patientenorientierte Versorgung [zum vollständigen Text gelangen Sie über die oben angegebene URL]

Hintergrund: Patientenorientierte Verordnung von Medikamenten bei multimorbiden, geriatrischen Patient*innen stellt die Behandelnden vor große Herausforderungen. Die gleichzeitige Einnahme von zehn oder mehr Medikamenten (exzessive Polypharmazie) ist keine Seltenheit und zeigte sich assoziiert [zum vollständigen Text gelangen Sie über die oben angegebene URL]

Introduction: Coronavirus disease (COVID-19) has recently dominated scientific literature. Incomplete understanding and a lack of data concerning the pathophysiology, epidemiology, and optimal treatment of the disease has resulted in conflicting recommendations. Adherence to existing guidelines and actual treatment strategies have thus far not been studied systematically. We hypothesized that capturing the variance in care would lead to the discovery of aspects that need further research and—in case of proven benefits of interventions not being performed—better communication to care providers. Methods: This article is based on a quantitative and qualitative cross-sectional mixed-methods online survey among intensive-care physicians in Germany during the COVID-19 pandemic by the CEOsys (COVID-19 Evidence Ecosystem) network, endorsed by the German Interdisciplinary Association for Intensive Care and Emergency Medicine (DIVI) conducted from December 3 to 31 December 2020. Results: We identified several areas of care with an especially high variance in treatment among hospitals in Germany. Crucially, 51.5% of the participating ICUs (n = 205) reported using intubation as a last resort for respiratory failure in COVID-19 patients, while 21.8% used intubation early after admission. Furthermore, 11.5% considered extracorporeal membrane oxygenation (ECMO) in awake patients. Finally, 72.3% of respondents used the ARDS-network-table to titrate positive end-expiratory-pressure (PEEP) levels, with 36.9% choosing the low-PEEP table and 41.8% the high-PEEP table. Conclusions: We found that significant differences exist between reported treatment strategies and that adherence to published guidelines is variable. We describe necessary steps for future research based on our results highlighting significant clinical variability in care.

Background/research question: Digitalization and the increasing availability of online information have changed the way in which information is searched for and retrieved by the public, and by health professionals. The technical developments of the last two decades have transformed the methods [for full text, please go to the a.m. URL], Who cares? – EbM und Transformation im Gesundheitswesen; 22. Jahrestagung des Deutschen Netzwerks Evidenzbasierte Medizin

Additional file 3. Participant questionnaire. Short questionnaire on socio-demographic and illness-related characteristics.

Additional file 4. Focus groups interview guide. Questions of the focus groups interview guide.

Additional file 2. Consolidated criteria for reporting qualitative studies (COREQ): 32-item checklist. Completed consolidated criteria for reporting qualitative studies (COREQ) checklist.

Hintergrund/Fragestellung: Mit der flächendeckenden Verbreitung des Internets in den letzten Dekaden hat sich auch der Zugang zu medizinischem Wissen stark verändert. Mit Einführung der Telematikinfrastruktur werden alle Praxen in Deutschland zu einem Internetanschluss verpflichtet.[zum vollständigen Text gelangen Sie über die oben angegebene URL], Nützliche patientenrelevante Forschung; 21. Jahrestagung des Deutschen Netzwerks Evidenzbasierte Medizin

BACKGROUND Although antihyperglycemic pharmacotherapy in frail older adults with type 2 diabetes mellitus (T2DM) is challenging, recommendations from international guidelines are mainly based on indirect evidence from trials not including frail participants. OBJECTIVE This systematic review investigated the effectiveness and safety of pharmacotherapy in frail older adults with T2DM. MATERIAL AND METHODS Randomized (RCT) and non-randomized prospective clinical trials (non-RCT) were searched in three electronic databases (Medline, Embase, Central) up to October 2018. Trials in older adults with T2DM who were assessed as significantly or severely impaired by defined cut-off scores of assessment instruments on frailty, activities of daily living or physical functional impairment were included. RESULTS Two reviewers independently screened 17,391 references for inclusion and assessed risk of bias with ROBINS‑I. Five non-RCTs and no RCT were identified. Treatment of T2DM without insulin compared to insulin could be associated with increased improvement in cardiac functions in patients with cardiac resynchronization therapy and with decreased falls in frail older women. While better glycemic control with low variability and low HbA1c (hemoglobin A1c) values (

Hintergrund: Patientenorientierung (PO) zielt auf eine Individualisierung der Gesundheitsversorgung entsprechend der spezifischen Bedürfnisse und Präferenzen eines Patienten. Die inkonsistente Definition und Verwendung des Begriffs erschwert jedoch die Entwicklung adäquater Messinstrumente[zum vollständigen Text gelangen Sie über die oben angegebene URL], 18. Deutscher Kongress für Versorgungsforschung (DKVF)