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7. Pre- and postoperative radiotherapy for extremity soft tissue sarcoma: Evaluation of inter-observer target volume contouring variability among French sarcoma group radiation oncologists

Author

Sargos, P., Charleux, T., Haas, R.L., Michot, A., Llacer, C., Moureau-Zabotto, L., Vogin, G., Le Péchoux, C., Verry, C., Ducassou, A., Delannes, M., Mervoyer, A., Wiazzane, N., Thariat, J., Sunyach, M.P., Benchalal, M., Laredo, J.D., Kind, M., Gillon, P., and Kantor, G.

Published
2018
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10. PD-0653 Target volume delineation for radiotherapy of meningiomas: an ANOCEF consensus guideline.

Author

MARTZ, N., primary, Salleron, J., additional, Dhermain, F., additional, Vogin, G., additional, Daisne, J., additional, Mouttet-Audouard, R., additional, Tanguy, R., additional, Noel, G., additional, Peyre, M., additional, Lecouillard, I., additional, Jacob, J., additional, Attal, J., additional, Charissoux, M., additional, Veresezan, O., additional, Hanzen, C., additional, Huchet, A., additional, Latorzeff, I., additional, Coutte, A., additional, Doyen, J., additional, Stefan, D., additional, Feuvret, L., additional, Garcia, G.C., additional, and Royer, P., additional

Published
2023
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14. ANOCEF Consensus Guideline on Target Volume Delineation for Meningiomas Radiotherapy

Author

Martz, N., primary, Salleron, J., additional, Dhermain, F., additional, Vogin, G., additional, Daisne, J.F., additional, Audouard, R. Mouttet, additional, Tanguy, R., additional, Noel, G., additional, Peyre, M., additional, Lecouillard, I., additional, Jacob, J., additional, Attal, J., additional, Charissoux, M., additional, Veresezan, O.V., additional, Hanzen, C., additional, Huchet, A., additional, Latorzeff, I., additional, Coutte, A., additional, Doyen, J., additional, Dinu, S., additional, Feuvret, L., additional, Garcia, G., additional, and Royer, P., additional

Published
2022
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23. Concepts and terms for dose/volume parameters in carbon-ion radiotherapy: Conclusions of the ULICE taskforce.

Author

UCL - SSS/IREC/MIRO - Pôle d'imagerie moléculaire, radiothérapie et oncologie, UCL - (SLuc) Service de radiothérapie oncologique, Vogin, G, Wambersie, A, Pötter, R, Beuve, M, Combs, S E, Magrin, G, Mayer, R, Mock, U, Sarrut, D, Schreiner, T, Fossati, P, Balosso, J, UCL - SSS/IREC/MIRO - Pôle d'imagerie moléculaire, radiothérapie et oncologie, UCL - (SLuc) Service de radiothérapie oncologique, Vogin, G, Wambersie, A, Pötter, R, Beuve, M, Combs, S E, Magrin, G, Mayer, R, Mock, U, Sarrut, D, Schreiner, T, Fossati, P, and Balosso, J

Abstract

The Union of Light Ion Centers in Europe (ULICE) program addressed the need for uniting scientific results for carbon-ion radiation therapy obtained by several institutions worldwide in different fields of excellence, and translating them into a real benefit to the community. Particularly, the concepts for dose/volume parameters developed in photon radiotherapy cannot be extrapolated to high linear energy transfer particles. The ULICE-WP2 taskforce included radiation oncologists involved in carbon-ion radiation therapy and International Commission on Radiation Units and Measurements, radiation biologists, expert physicists in the fields of carbon-ion radiation therapy, microdosimetry, biological modeling and image-guided radiotherapy. Consensual reports emerged from multiple discussions within both the restricted group and the wider ULICE community. Public deliverables were produced and disseminated to the European Commission. Here we highlight the disparity in practices between treating centers, then address the main topics to finally elaborate specific recommendations. Although it appears relatively simple to add geometrical margins around the clinical target volume to obtain the planning target volume as performed in photon radiotherapy, this procedure is not appropriate for carbon-ion radiation therapy. Due to the variation of the radiation quality in depth, there is no generic relative biological effectiveness value for carbon-ions outside of an isolated point, for a given fractionation and specific experimental conditions. Absorbed dose and "equieffective dose" for specified conditions must always be reported. This work contributed to the development of standard operating procedures for carbon-ion radiation therapy clinical trials. These procedures are now being applied, particularly in the first phase III international, multicenter trial (PHRC Étoile).

Published
2018

25. Radiation Therapy in Extracranial Chondrosarcomas: A Multicenter French Sarcoma Group and Rare Cancer Network Study

Author

Terlizzi, M., primary, Rapeaud, E., additional, Le Pechoux, C., additional, Salas, S., additional, Lerouge, D., additional, Sunyach, M.P., additional, Vogin, G., additional, Sole, C.V., additional, Zilli, T., additional, Myroslav, L., additional, Mampuya, A., additional, Calvo, F.A., additional, Attal, J., additional, De Bari, B., additional, Ozsahin, M., additional, Sargos, P., additional, and Thariat, J.O., additional

Published
2018
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26. Radiothérapie des chondrosarcomes extracrâniens : étude multicentrique du Groupe sarcome français et du Rare Cancer Network

Author

Terlizzi, M.L., primary, Rapeaud, E., additional, Le Péchoux, C., additional, Salas, S., additional, Lerouge, D., additional, Sunyach, M.-P., additional, Vogin, G., additional, Solé, C., additional, Zilli, T., additional, Myroslav, L., additional, Mampuya, A., additional, Calvo, F.A., additional, Attal, J., additional, De Bari, B., additional, Ozsahin, M., additional, Sargos, P., additional, and Thariat, J., additional

Published
2018
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29. [Conformal radiotherapy for vertebral bone metastasis]

Author

Faivre, Jc, Py, Jf, Vogin, G., Martinage, G., Salleron, J., Royer, P., Grandgirard, N., Pasquier, D., Thureau, S., Equipe Quantification en Imagerie Fonctionnelle (QuantIF-LITIS), Laboratoire d'Informatique, de Traitement de l'Information et des Systèmes (LITIS), Université Le Havre Normandie (ULH), Normandie Université (NU)-Normandie Université (NU)-Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Institut national des sciences appliquées Rouen Normandie (INSA Rouen Normandie), Institut National des Sciences Appliquées (INSA)-Normandie Université (NU)-Institut National des Sciences Appliquées (INSA)-Université Le Havre Normandie (ULH), and Institut National des Sciences Appliquées (INSA)-Normandie Université (NU)-Institut National des Sciences Appliquées (INSA)

Subjects
Organs at Risk, Spinal Neoplasms, Radiotherapy, Soins oncologiques de supports, Conformal, Intensity-modulated, Vertèbre, Pain, Bone metastasis, [SDV.CAN]Life Sciences [q-bio]/Cancer, Métastase osseuse, Decompression, Surgical, Spine, Douleur, Patient Education as Topic, Back Pain, Quality of Life, Humans, Radiotherapy, Conformal, Spinal Cord Compression, Supportive care, Radiotherapy, Image-Guided, Radiothérapie
Abstract

International audience; Analgesic external beam radiation therapy is a standard of care for patients with uncomplicated painful bone metastases and/or prevention of bone complications. In case of fracture risk, radiation therapy is performed after surgery in a consolidation of an analgesic purpose and stabilizing osteosynthesis. Radiotherapy is mandatory after vertebroplasty or kyphoplasty. Spinal cord compression - the only emergency in radiation therapy - is indicated postoperatively either exclusively for non surgical indication. Analgesic re-irradiation is possible in the case of insufficient response or recurrent pain after radiotherapy. Metabolic radiation, bisphosphonates or denosumab do not dissuade external radiation therapy for pain relief. Systemic oncological treatments can be suspended with a period of wash out given the risk of radiosensitization or recall phenomenon. Better yet, the intensity modulated radiotherapy and stereotactic radiotherapy can be part of a curative strategy for oligometastatic patients and suggest new treatment prospects.

Published
2016

35. Radiothérapie adaptative des cancers ORL : un outil permettant d’identifier les patients nécessitant une adaptation de leur traitement

Author

Huger, S., Graff, P., Marchesi, V., Vogin, G., Guinement, L., Serre, A.A., Peiffert, D., Institut de Cancérologie de Lorraine - Alexis Vautrin [Nancy] (UNICANCER/ICL), UNICANCER, Institut Universitaire du Cancer de Toulouse - Oncopole (IUCT Oncopole - UMR 1037), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-CHU Toulouse [Toulouse]-Institut National de la Santé et de la Recherche Médicale (INSERM), Ingénierie Moléculaire et Physiopathologie Articulaire (IMoPA), Université de Lorraine (UL)-Centre National de la Recherche Scientifique (CNRS), Maladies chroniques, santé perçue, et processus d'adaptation (APEMAC), Université Paris Descartes - Paris 5 (UPD5)-Université de Lorraine (UL), and Institut de Cancérologie de Lorraine - Alexis Vautrin (ICL)

Subjects
Male, ORL, Patient Selection, Radiotherapy Planning, Computer-Assisted, Radiothérapie adaptative, Dosimetric alert tool, CBCT, Middle Aged, Outil d’alerte dosimétrique, Otorhinolaryngologic Neoplasms, Head and neck, Adaptive radiotherapy, Head and Neck Neoplasms, Humans, Female, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, Tomographie conique, Retrospective Studies
Abstract

International audience; PURPOSE:The purpose of this work was to implement a simple dosimetric alert tool in a retrospective study for six patients suffering from head and neck cancer to detect when a patient might require an adaptive radiotherapy.MATERIALS AND METHODS:The dosimetric tool generates a 3D cartography of two dosimetric complementary information: a dose variation tolerance map and a dose differential map. The tolerance map is calculated on the initial scanner (CTinit) using the planned dose distribution. It shows for each voxel of each delineated volume the availability for local dose variations during the course of radiotherapy without exceeding the dose threshold. The differential dose map is generated on the tomographic image CBCT (CBCTtreatment). It shows dose variations between the planned and the actual delivered dose distribution for each voxel. By comparing both maps, when a voxel presents a value superior to the corresponding dose variation tolerance, an alert is generated and the anatomical areas concerned are visually indicated to the physician.RESULTS:The application of the dosimetric tool on six patients with head and neck cancers reveals the ability of the tool to detect cases requiring a new treatment plan. Two patients whose the tumour shrinkage produced an increase of the delivered dose to the spinal cord beyond 45 Gy have been detected.CONCLUSION:The development of the dosimetric tool allows the automatic detection, with no delineation needs, of patients suffering from head and neck cancers requiring an adaptive strategy.; Objectif de l’étudeL’objectif de ce travail était d’implémenter un outil d’alerte dosimétrique simple dans une étude rétrospective portant sur six patients ORL afin de détecter les situations où une adaptation de traitement était requise.Matériel et méthodesL’outil dosimétrique génère la cartographie tridimensionnelle de deux informations dosimétriques complémentaires : une carte de tolérance de variation de dose et une carte de différentielle de dose. La carte de tolérance est calculée à partir de la distribution de dose planifiée sur la scanographie initiale. Elle affiche pour chaque voxel de chaque organe délinéé, les variations acceptables de dose au cours des séances d’irradiation sans excéder les contraintes dosimétriques. La carte de différence de dose est générée suite au calcul de dose réelle sur l’image tomographique conique. Les variations de dose entre la distribution planifiée et la distribution réelle sont affichées pour chaque voxel. En comparant les deux cartes, lorsqu’un voxel présente une valeur supérieure à la tolérance de variation de dose correspondante, un système d’alerte se déclenche et la zone anatomique concernée est visuellement indiquée au médecin.RésultatsL’implémentation de l’outil d’alerte sur six patients atteints de cancer de la sphère ORL, avec une tomographie conique hebdomadaire, a révélé l’aptitude de l’outil à détecter les cas justifiant un nouveau plan de traitement. Deux patients chez qui la régression tumorale engendrait une majoration de la dose délivrée au canal médullaire au-delà de 45 Gy ont été détectés.ConclusionLe développement de cet outil de détection automatique permet d’orienter rapidement, et sans délinéation médicale, les patients atteints de cancer ORL vers une stratégie de radiothérapie adaptative.

Published
2015

38. Étude multicentrique des pratiques de la radiothérapie des sarcomes des tissus mous des membres en France : impact carcinologique et fonctionnel

Author

Llacer, C., primary, Le-Péchoux, C., additional, Sunyach, M., additional, Ducassou, A., additional, Delannes, M., additional, Noël, G., additional, Thariat, J., additional, Sargos, P., additional, Kantor, G., additional, Vogin, G., additional, Fourquet, J., additional, and Moureau-Zabotto, L., additional

Published
2016
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41. PO-0768: Evaluation of RT practice for limb soft tissue sarcomas and its impact on prognosis and toxicity

Author

Llacer-Moscardo, C., primary, Le Pechoux, C., additional, Sunyach, M.P., additional, Thezenas, S., additional, Ducassou, A., additional, Delannes, M., additional, Noel, G., additional, Thariat, J., additional, Vogin, G., additional, Fourquet, J., additional, Vilotte, F., additional, Sargos, P., additional, Kantor, G., additional, Chapet, S., additional, and Moureau-Zabotto, L., additional

Published
2016
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43. 3402 Time interval (TI) between surgery and start of adjuvant radiotherapy (RT): A retrospective analysis of 1150 cases from the French Sarcoma Group

Author

Fourquet, J., primary, Vilotte, F., additional, Sunyach, M.P., additional, LePéchoux, C., additional, Ranchère-Vince, D., additional, Bonvalot, S., additional, Coindre, J.M., additional, Terrier, P., additional, Meeus, P., additional, Kao, W., additional, Biau, J., additional, Helfre, S., additional, Martin, E., additional, Vogin, G., additional, Penel, N., additional, Stoeckle, E., additional, and Sargos, P., additional

Published
2015
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