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4 results on '"Vogel, S. de"'

1. Associations of dietary methyl donor intake with MLH1 promoter hypermethylation and related molecular phenotypes in sporadic colorectal cancer

Author

Vogel, S. de, Bongaerts, B.W.C., Wouters, K.A.D., Kester, A.D.M., Schouten, L.J., Goeij, A.F.P.M. de, Bruïne, A.P. de, Goldbohm, R.A., Brandt, P.A. van den, Engeland, M. van, Weijenberg, M.P., and TNO Kwaliteit van Leven

Subjects
Male, Proto-Oncogene Proteins B-raf, Questionnaires, Riboflavin, Vitamin intake, Protein methylation, Cohort Studies, Cancer risk, Folic Acid, Methionine, Humans, Alcohol consumption, Gene mutation, neoplasms, Netherlands, Adaptor Proteins, Signal Transducing, Aged, Dietary intake, Promoter region, Nuclear Proteins, Colon carcinogenesis, DNA, Neoplasm, DNA Methylation, Middle Aged, Sex difference, digestive system diseases, Vitamin B 6, Diet, Colorectal carcinoma, Vitamin B 12, Phenotype, Health, Mutation, Microsatellite instability, Protein expression, Epigenetics, Female, Promoter Regions (Genetics), Cohort analysis, Colorectal Neoplasms, Cancer incidence, Microsatellite Repeats
Abstract

Intake of dietary factors that serve as methyl group donors may influence promoter hypermethylation in colorectal carcinogenesis. We investigated whether dietary folate, vitamin B2 and vitamin B6, methionine and alcohol were associated with mutL homologue 1 (MLH1) hypermethylation and the related molecular phenotypes of MLH1 protein expression, microsatellite instability (MSI) and BRAF mutations in patients with colorectal carcinomas. Within the Netherlands Cohort Study on diet and cancer (n = 120 852), 648 cases (367 men and 281 women) and 4059 subcohort members were available for data analyses from a follow-up period between 2.3 and 7.3 years after baseline. Gender-specific adjusted incidence rate ratios (RRs) were calculated over categories of dietary intake in case-cohort analyses. The intakes of folate, vitamin B2, methionine and alcohol were not associated with risk of tumors showing MLH1 hypermethylation, those lacking MLH1 protein expression or with MSI. Among men, we observed strong positive associations between folate and BRAF-mutated tumors (RR = 3.04 for the highest versus lowest tertile of intake, Ptrend = 0.03) and between vitamin B6 and tumors showing MLH1 hypermethylation (highest versus lowest tertile: RR = 3.23, Ptrend = 0.03). Among women, the relative risks of tumors with BRAF mutations or MLH1 hypermethylation were also increased in the highest tertiles of folate and vitamin B6 intake, respectively, but these did not reach statistical significance. The positive associations between folate intake and tumors harboring BRAF mutations and between vitamin B6 intake and those showing MLH1 hypermethylation were most pronounced among men and may suggest that these vitamins enhance colorectal cancer risk through genetic as well as epigenetic aberrations. © The Author 2008. Published by Oxford University Press. All rights reserved.

Published
2008

2. Alcohol consumption and distinct molecular pathways to colorectal cancer

Author

Bongaerts, B.W.C., Goeij, A.F.P.M. de, Vogel, S. de, Brandt, P.A. van den, Goldbohm, R.A., Weijenberg, M.P., and TNO Kwaliteit van Leven

Subjects
tumor classification, Male, protein p53, cancer risk, protein MLH1, human experiment, middle aged, genetics, gene mutation, tumor suppressor gene, Netherlands, statistical significance, adult, article, drinking behavior, risk assessment, clinical trial, cohort analysis, APC protein, aged, female, nutritional assessment, risk factor, Health, epidemiology, Microsatellite Instability, Alcohol, Cohort study, Colorectal Neoplasms, Genes, APC, chromosomal instability, Alcohol Drinking, alcohol consumption, gene overexpression, Food and Chemical Risk Analysis, colorectal cancer, Humans, controlled study, Genetic Predisposition to Disease, human, normal human, protein expression, questionnaire, The Netherlands, human tissue, K ras protein, multicenter study, confidence interval, Mutation, incidence, Epidemiologic Methods, genetic predisposition, colorectal tumor
Abstract

High alcohol consumption is related to colorectal cancer (CRC). Our objective was to study associations between alcohol consumption and risk of CRC according to characteristics of aetiological pathways: the chromosomal instability (CIN) and the microsatellite instability (MIN) pathway. We classified CIN+ tumours (tumours with either a truncating APC mutation, an activating K-ras mutation or overexpression of p53), MIN+ tumours (tumours lacking hMLH1 expression) and CIN-/MIN- tumours (tumours without these defects). In the Netherlands Cohort Study on diet and cancer, 120 852 men and women, aged 55-69 years, completed a questionnaire on risk factors for cancer at baseline (1986). Case-cohort analyses were conducted using 573 CRC cases with complete data after 7.3 years of follow-up, excluding the first 2.3 years. Adjusted incidence rate ratios (RR) and 95% confidence intervals (CI) were estimated. Compared with abstaining, alcohol consumption of ≥30 g/d was positively associated with the risk of CRC irrespective of genetic or molecular aberrations present, although statistical significance was not reached (RR 1.35 (95% CI 0.9-2.0) for the CIN+ tumours, RR 1.59 (95% CI 0.4-5.8) for the MIN+ tumours and RR 1.15 (95% CI 0.5-2.7) for the CIN-/MIN- tumours). Beer, wine and liquor consumption were, independent of their alcoholic content, not consistently associated with the risk of CRC within the defined subgroups. In conclusion, our results indicate that a daily alcohol consumption of ≥ 30 g is associated with an increase in risk of CRC, independent of the presence or absence of the studied characteristics of different aetiological pathways.

Published
2007

3. Biomarkers related to one-carbon metabolism as potential risk factors for distal colorectal adenomas

Author

Vogel, S. de, Schneede, J., Ueland, P.M., Vollset, S.E., Meyer, K., Fredriksen, A., Midttun, O., Bjorge, T., Kampman, E., Bretthauer, M., Hoff, G., Vogel, S. de, Schneede, J., Ueland, P.M., Vollset, S.E., Meyer, K., Fredriksen, A., Midttun, O., Bjorge, T., Kampman, E., Bretthauer, M., and Hoff, G.

Abstract

Item does not contain fulltext, BACKGROUND: Efficient one-carbon metabolism, which requires adequate supply of methyl group donors and B-vitamins, may protect against colorectal carcinogenesis. However, plasma folate and vitamins B2 and B12 have inconsistently been associated with colorectal cancer risk, and there have been no previous studies relating plasma concentrations of methionine, choline, and betaine to this outcome. METHODS: This study comprised 10,601 individuals, 50 to 64 years of age, participating in the Norwegian Colorectal Cancer Prevention (NORCCAP) screening study. Using logistic regression analyses, we crosssectionally investigated associations between distal colorectal adenoma occurrence-potential precursor lesions of colorectal carcinomas-and plasma concentrations of methyl group donors and B-vitamins, and polymorphisms of genes related to one-carbon metabolism. RESULTS: Screening revealed 1,809 subjects (17.1%) with at least one adenoma. The occurrence of high-risk adenomas (observed in 421 subjects) was inversely associated with plasma concentrations of methionine (highest versus lowest quartile: odds ratio (OR) = 0.61; 95% confidence interval (CI) = 0.45-0.83), betaine: OR = 0.74; 95% CI = 0.54-1.02, the vitamin B2 form flavin-mononucleotide (FMN): OR = 0.65; 95% CI = 0.49-0.88, and the vitamin B6 form pyridoxal 5'-phosphate (PLP): OR = 0.69; 95% CI = 0.51-0.95, but not with folate, choline, vitamin B12 concentrations, or with the studied polymorphisms. High methionine concentration in combination with high vitamin B2 or B6 concentrations was associated with lower occurrence of high-risk adenomas compared with these factors individually. CONCLUSIONS: High plasma concentrations of methionine and betaine, and vitamins B2 and B6 may reduce risk of developing colorectal adenomas. IMPACT: In addition to B-vitamins, methyl group donors such as methionine and betaine may play a role in colorectal carcinogenesis.

Published
2011

4. Alcohol consumption and mutations or promoter hypermethylation of the von Hippel-Lindau gene in renal cell carcinoma.

Author

Schouten, L.J., Dijk, B.A.C. van, Oosterwijk, E., Engeland, M. van, Hulsbergen-van de Kaa, C.A., Kiemeney, L.A.L.M., Goldbohm, R.A., Kester, A., Vogel, S. de, Schalken, J.A., Brandt, P.A. van den, Schouten, L.J., Dijk, B.A.C. van, Oosterwijk, E., Engeland, M. van, Hulsbergen-van de Kaa, C.A., Kiemeney, L.A.L.M., Goldbohm, R.A., Kester, A., Vogel, S. de, Schalken, J.A., and Brandt, P.A. van den

Abstract

Contains fulltext : 69626.pdf (publisher's version ) (Closed access), Alcohol consumption has been associated with a decreased risk for renal cell cancer in several studies. We investigated whether alcohol is associated with (epi)genetic changes of the von Hippel-Lindau (VHL) gene in renal cell cancer. The Netherlands Cohort Study (NLCS) on Diet and Cancer started in 1986 (n = 120,852) and uses the case-cohort method. After 11.3 years of follow-up, 314 renal cell cancer cases and 4,511 subcohort members were available for analysis. DNA was isolated from paraffin-embedded tumor tissue from 235 cases. VHL mutations were analyzed by sequencing, whereas VHL promoter methylation was analyzed using methylation-specific PCR. In multivariate analysis, hazard ratios of renal cell cancer for cohort members who consumed up to 5, 15, 30, and > or = 30 g of alcohol per day were 0.72, 0.64, 0.81, and 0.69, respectively, compared with nondrinkers [95% confidence interval (95% CI) for the > or = 30 category, 0.44-1.07; P for trend, 0.17]. Alcohol intake from beer, wine, and liquor was associated with decreased risks for renal cell cancer, although not statistically significant. Hazard ratios were not different for clear-cell renal cell cancer with and without VHL mutations, except for alcohol from beer, which was associated with an increased risk for clear-cell renal cell cancer without VHL mutations (hazard ratio for > or = 5 g of alcohol from beer compared with nondrinkers, 2.74; 95% CI, 1.35-5.57). Alcohol was associated with a decreased risk for clear-cell renal cell cancer without VHL gene promoter methylation (hazard ratio for >15 g compared with nondrinkers, 0.58; 95% CI, 0.34-0.99). In this study, a not statistically significant inverse association was observed between alcohol and renal cell cancer. There was no statistical significant heterogeneity by VHL mutation or methylation status.

Published
2008

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