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2. Plasticity mechanisms of genetically distinct Purkinje cells

Author

Voerman, Stijn, Broersen, Robin, Swagemakers, Sigrid M A, De Zeeuw, Chris I, van der Spek, Peter J, Voerman, Stijn, Broersen, Robin, Swagemakers, Sigrid M A, De Zeeuw, Chris I, and van der Spek, Peter J

Abstract

Despite its uniform appearance, the cerebellar cortex is highly heterogeneous in terms of structure, genetics and physiology. Purkinje cells (PCs), the principal and sole output neurons of the cerebellar cortex, can be categorized into multiple populations that differentially express molecular markers and display distinctive physiological features. Such features include action potential rate, but also their propensity for synaptic and intrinsic plasticity. However, the precise molecular and genetic factors that correlate with the differential physiological properties of PCs remain elusive. In this article, we provide a detailed overview of the cellular mechanisms that regulate PC activity and plasticity. We further perform a pathway analysis to highlight how molecular characteristics of specific PC populations may influence their physiology and plasticity mechanisms.

Published
2024

3. Plasticity mechanisms of genetically distinct Purkinje cells.

Author

Voerman S, Broersen R, Swagemakers SMA, De Zeeuw CI, and van der Spek PJ

Subjects
Animals, Humans, Action Potentials physiology, Synapses physiology, Synapses metabolism, Synapses genetics, Cerebellar Cortex cytology, Cerebellar Cortex metabolism, Cerebellar Cortex physiology, Purkinje Cells metabolism, Purkinje Cells physiology, Neuronal Plasticity genetics
Abstract

Despite its uniform appearance, the cerebellar cortex is highly heterogeneous in terms of structure, genetics and physiology. Purkinje cells (PCs), the principal and sole output neurons of the cerebellar cortex, can be categorized into multiple populations that differentially express molecular markers and display distinctive physiological features. Such features include action potential rate, but also their propensity for synaptic and intrinsic plasticity. However, the precise molecular and genetic factors that correlate with the differential physiological properties of PCs remain elusive. In this article, we provide a detailed overview of the cellular mechanisms that regulate PC activity and plasticity. We further perform a pathway analysis to highlight how molecular characteristics of specific PC populations may influence their physiology and plasticity mechanisms., (© 2024 The Authors. BioEssays published by Wiley Periodicals LLC.)

Published
2024
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