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1. Voedselovergevoeligheid

Author

Vlieg-Boerstra, Berber, Oude Elberink, Hanneke, Sprikkelman, Aline, van Doorn, Olga, Soeters, Maarten, editor, Wierdsma, Nicolette, editor, Kruizenga, Hinke, editor, and Bouma, Gerd, editor

Published
2023
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3. Managing food allergy: GA2LEN guideline 2022

Author

Bansal, Priya, Berni–Canani, Roberto, Blumchen, Katharina, Bonertz, Andreas, Bourgoin-Heck, Melisande, Ceylon, Ozlem, Divaret-Chauveau, Amandine, Fleischer, David, Gomez, Maximiliano, Groetch, Marion, Hernandez, Domingo Barber, Hjorth, Betina, Hussey, Lydia Collins, Knulst, André C., Leung, Agnes, Mack, Douglas, Mahler, Vera, Mori, Francesca, Namazova-Baranova, Leyla, Palosuo, Kati, Parisi, Claudio Alberto Salvador, Pastorino, Antonio Carlos, Rudzeviciene, Odilija, Said, Maria, Sawiec, Piotr, Sicherer, Scott, Sato, Sakura, Zubchenko, Svitlana, Muraro, Antonella, de Silva, Debra, Halken, Susanne, Worm, Margitta, Khaleva, Ekaterina, Arasi, Stefania, Dunn-Galvin, Audrey, Nwaru, Bright I., De Jong, Nicolette W., Rodríguez Del Río, Pablo, Turner, Paul J., Smith, Pete, Begin, Philippe, Angier, Elizabeth, Arshad, Hasan, Ballmer-Weber, Barbara, Beyer, Kirsten, Bindslev-Jensen, Carsten, Cianferoni, Antonella, Demoulin, Céline, Deschildre, Antoine, Ebisawa, Motohiro, Fernandez-Rivas, Maria Montserrat, Fiocchi, Alessandro, Flokstra-de Blok, Bertine, Gerdts, Jennifer, Gradman, Josefine, Grimshaw, Kate, Jones, Carla, Lau, Susanne, Loh, Richard, Alvaro Lozano, Montserrat, Makela, Mika, Marchisotto, Mary Jane, Meyer, Rosan, Mills, Clare, Nilsson, Caroline, Nowak-Wegrzyn, Anna, Nurmatov, Ulugbek, Pajno, Giovanni, Podestà, Marcia, Poulsen, Lars K., Sampson, Hugh A., Sanchez, Angel, Schnadt, Sabine, Szajewska, Hania, Van Ree, Ronald, Venter, Carina, Vlieg-Boerstra, Berber, Warner, Amena, Wong, Gary, Wood, Robert, Zuberbier, Torsten, and Roberts, Graham

Published
2022
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4. Dietary Management of Food Allergy

Author

Durban, Raquel, Groetch, Marion, Meyer, Rosan, Coleman Collins, Sherry, Elverson, Wendy, Friebert, Alyssa, Kabourek, Jamie, Marchand, Stephanie M., McWilliam, Vicki, Netting, Merryn, Skypala, Isabel, Van Brennan, Taryn, Vassilopoulou, Emillia, Vlieg–Boerstra, Berber, and Venter, Carina

Published
2021
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5. Dietary composition of adult eosinophilic esophagitis patients is related to disease severity

Author

Eussen, Simone R.B.M., Wielders, Sanne, de Rooij, Willemijn E., Van Ampting, Marleen T.J., Van Esch, Betty C.A.M., de Vries, Jeanne H.M., Bredenoord, Albert J., Vlieg-Boerstra, Berber, Eussen, Simone R.B.M., Wielders, Sanne, de Rooij, Willemijn E., Van Ampting, Marleen T.J., Van Esch, Betty C.A.M., de Vries, Jeanne H.M., Bredenoord, Albert J., and Vlieg-Boerstra, Berber

Abstract

Background: In addition to the elimination diet, dietary composition may influence disease severity in patients with eosinophilic esophagitis (EoE) through modulation of the immune response. Aim: To explore the immunomodulatory role of nutrition before and during elimination diet in adult EoE patients. Methods: Nutritional intake was assessed in 39 Dutch adult EoE patients participating in the Supplemental Elemental Trial (Dutch trial registry NL6014, NTR6778) using 3-day food diaries. In this randomized controlled trial, diagnosed patients received either a four-food elimination diet alone (FFED) or FFED with addition of an amino acid-based formula for 6 weeks. Multiple linear regression analyses were performed to assess associations between the intake of nutrients and food groups per 1000 kCal and peak eosinophil count/high power field (PEC), both at baseline and after 6 weeks. Results: At baseline, we found a statistically significant negative (thus favorable) relationship between the intake of protein, total fat, phosphorus, zinc, vitamin B12, folate, and milk products and PEC (p <.05), while calcium (p =.058) and full-fat cheese/curd (p =.056) were borderline (favorably) significant. In contrast, total carbohydrates, prepacked fruit juice, and white bread were significantly positively (unfavorable) related to PEC (p <.05), while ultra-processed meals (p =.059) were borderline (unfavorably) significant. After dietary intervention, coffee/tea were significantly negatively (favorably) related to PEC, hummus/legumes were significantly positively (unfavorably) related with PEC, while peanuts were borderline significantly positively related (p =.058). Conclusion: Dietary composition may be related to inflammation in adult EoE patients. High-quality and anti-inflammatory diets may be a promising adjuvant therapy in the dietary management of EoE.

Published
2024

6. Dietary composition of adult eosinophilic esophagitis patients is related to disease severity

Author

Afd Pharmacology, Pharmacology, Eussen, Simone R.B.M., Wielders, Sanne, de Rooij, Willemijn E., Van Ampting, Marleen T.J., Van Esch, Betty C.A.M., de Vries, Jeanne H.M., Bredenoord, Albert J., Vlieg-Boerstra, Berber, Afd Pharmacology, Pharmacology, Eussen, Simone R.B.M., Wielders, Sanne, de Rooij, Willemijn E., Van Ampting, Marleen T.J., Van Esch, Betty C.A.M., de Vries, Jeanne H.M., Bredenoord, Albert J., and Vlieg-Boerstra, Berber

Published
2024

7. A systematic review and meta‐analysis on nutritional and dietary interventions for the treatment of acute respiratory infection in pediatric patients: An EAACI taskforce.

Author

Milani, Gregorio P., Alberti, Ilaria, Abodi, Martina, Lakoumentas, John, Konstantinou, George N., Papadopoulos, Nikolaos G., Pop, Raluca M., Bocsan, Ioana C., Cassimos, Dimitrios, Kull, Inger, Bettocchi, Silvia, Corsello, Antonio, Cugliari, Marco, Ciliberti, Letizia, Spolidoro, Giulia C. I., Agostoni, Carlo, Vlieg Boerstra, Berber, Venter, Carina, O'Mahony, Liam, and Vassilopoulou, Emilia

Subjects
RESPIRATORY infections, PEDIATRIC respiratory diseases, RESPIRATORY infections in children, CHILD patients, VITAMIN A
Abstract

Acute respiratory infections are a major cause of morbidity and mortality in children worldwide. Dietary and nutritional interventions, including minerals and vitamin supplementation, have been explored as potential treatments for these infections. However, the evidence on their efficacy is limited and inconclusive. This systematic review and meta‐analysis aim to provide a comprehensive summary of the available evidence on the effectiveness of dietary and nutritional interventions for treating acute respiratory tract infections in children. A systematic review was conducted according to the PRISMA 2020 guidelines in April 2022 and updated in April 2023. Clinical trials focusing on dietary or nutritional interventions, including supplementations, in children with acute respiratory tract infections were included. The selection of interventions and outcomes was based on biological plausibility. Data were extracted using a standardized form, and the risk of bias was assessed using the Cochrane Risk of Bias Tool. Meta‐analysis was performed using random‐effect models. A total of 50 studies were included in the review. Four trials were conducted in low, 32 in lower‐middle, 12 in upper‐middle, and only two in high‐income countries. The studies evaluated various dietary interventions, including zinc, vitamin A, vitamin E, vitamin D, and probiotics. The results of individual studies on the efficacy of these interventions were mixed, with some showing positive effects on clinical outcomes such as duration of symptoms, while others showed no significant impact. Meta‐analysis was conducted for zinc supplementation in children with pneumonia, and the pooled results suggested a potential limited benefit in terms of reduced hospital length of stay but not time to recovery. Meta‐analyses on vitamin D did not show any effect in children with pneumonia. This systematic review fills a critical gap in the literature by synthesizing the available evidence on the efficacy and safety of nutritional or dietary interventions for acute respiratory tract infections in children. The findings indicate no dietary or nutritional intervention can currently be recommended for the routine treatment of respiratory tract infections in children based on single supplement studies. The metanalysis suggests that zinc supplementation might have a beneficial effect on length of hospitalization in children with pneumonia. New studies are needed to establish more conclusive evidence for pediatric acute respiratory diseases especially for children living in a context of high‐income countries. [ABSTRACT FROM AUTHOR]

Published
2024
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8. Conducting an Oral Food Challenge: An Update to the 2009 Adverse Reactions to Foods Committee Work Group Report

Author

Bird, J. Andrew, Leonard, Stephanie, Groetch, Marion, Assa'ad, Amal, Cianferoni, Antonella, Clark, April, Crain, Maria, Fausnight, Tracy, Fleischer, David, Green, Todd, Greenhawt, Matthew, Herbert, Linda, Lanser, Bruce J., Mikhail, Irene, Mustafa, Shahzad, Noone, Sally, Parrish, Christopher, Varshney, Pooja, Vlieg-Boerstra, Berber, Young, Michael C., Sicherer, Scott, and Nowak-Wegrzyn, Anna

Published
2020
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9. Food allergy outside the eight big foods in Europe: A systematic review and meta‐analysis

Author

Spolidoro, Giulia C. I., primary, Nyassi, Sungkutu, additional, Lisik, Daniil, additional, Ioannidou, Athina, additional, Ali, Mohamed Mustafa, additional, Amera, Yohannes Tesfaye, additional, Rovner, Graciela, additional, Khaleva, Ekaterina, additional, Venter, Carina, additional, van Ree, Ronald, additional, Worm, Margitta, additional, Vlieg‐Boerstra, Berber, additional, Sheikh, Aziz, additional, Muraro, Antonella, additional, Roberts, Graham, additional, and Nwaru, Bright I., additional

Published
2024
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12. Dietary composition of adult eosinophilic esophagitis patients is related to disease severity.

Author

Eussen, Simone R. B. M., Wielders, Sanne, de Rooij, Willemijn E., Van Ampting, Marleen T. J., Van Esch, Betty C. A. M., de Vries, Jeanne H. M., Bredenoord, Albert J., and Vlieg‐Boerstra, Berber

Subjects
EOSINOPHILIC esophagitis, ELIMINATION diets, FOOD diaries, ADULTS, MULTIPLE regression analysis, DIET therapy
Abstract

Background: In addition to the elimination diet, dietary composition may influence disease severity in patients with eosinophilic esophagitis (EoE) through modulation of the immune response. Aim: To explore the immunomodulatory role of nutrition before and during elimination diet in adult EoE patients. Methods: Nutritional intake was assessed in 39 Dutch adult EoE patients participating in the Supplemental Elemental Trial (Dutch trial registry NL6014, NTR6778) using 3‐day food diaries. In this randomized controlled trial, diagnosed patients received either a four‐food elimination diet alone (FFED) or FFED with addition of an amino acid‐based formula for 6 weeks. Multiple linear regression analyses were performed to assess associations between the intake of nutrients and food groups per 1000 kCal and peak eosinophil count/high power field (PEC), both at baseline and after 6 weeks. Results: At baseline, we found a statistically significant negative (thus favorable) relationship between the intake of protein, total fat, phosphorus, zinc, vitamin B12, folate, and milk products and PEC (p <.05), while calcium (p =.058) and full‐fat cheese/curd (p =.056) were borderline (favorably) significant. In contrast, total carbohydrates, prepacked fruit juice, and white bread were significantly positively (unfavorable) related to PEC (p <.05), while ultra‐processed meals (p =.059) were borderline (unfavorably) significant. After dietary intervention, coffee/tea were significantly negatively (favorably) related to PEC, hummus/legumes were significantly positively (unfavorably) related with PEC, while peanuts were borderline significantly positively related (p =.058). Conclusion: Dietary composition may be related to inflammation in adult EoE patients. High‐quality and anti‐inflammatory diets may be a promising adjuvant therapy in the dietary management of EoE. [ABSTRACT FROM AUTHOR]

Published
2024
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13. EAACI guidelines on the diagnosis of IgE‐mediated food allergy

Author

Santos, Alexandra F., primary, Riggioni, Carmen, additional, Agache, Ioana, additional, Akdis, Cezmi A., additional, Akdis, Mubeccel, additional, Alvarez‐Perea, Alberto, additional, Alvaro‐Lozano, Montserrat, additional, Ballmer‐Weber, Barbara, additional, Barni, Simona, additional, Beyer, Kirsten, additional, Bindslev‐Jensen, Carsten, additional, Brough, Helen A., additional, Buyuktiryaki, Betul, additional, Chu, Derek, additional, Del Giacco, Stefano, additional, Dunn‐Galvin, Audrey, additional, Eberlein, Bernadette, additional, Ebisawa, Motohiro, additional, Eigenmann, Philippe, additional, Eiwegger, Thomas, additional, Feeney, Mary, additional, Fernandez‐Rivas, Montserrat, additional, Fisher, Helen R., additional, Fleischer, David M., additional, Giovannini, Mattia, additional, Gray, Claudia, additional, Hoffmann‐Sommergruber, Karin, additional, Halken, Susanne, additional, Hourihane, Jonathan O’B., additional, Jones, Christina J., additional, Jutel, Marek, additional, Knol, Edward, additional, Konstantinou, George N., additional, Lack, Gideon, additional, Lau, Susanne, additional, Marques Mejias, Andreina, additional, Marchisotto, Mary Jane, additional, Meyer, Rosan, additional, Mortz, Charlotte G., additional, Moya, Beatriz, additional, Muraro, Antonella, additional, Nilsson, Caroline, additional, Lopes de Oliveira, Lucila Camargo, additional, O’Mahony, Liam, additional, Papadopoulos, Nikolaos G., additional, Perrett, Kirsten, additional, Peters, Rachel L., additional, Podesta, Marcia, additional, Poulsen, Lars K., additional, Roberts, Graham, additional, Sampson, Hugh A., additional, Schwarze, Jürgen, additional, Smith, Peter, additional, Tham, Elizabeth Huiwen, additional, Untersmayr, Eva, additional, Van Ree, Ronald, additional, Venter, Carina, additional, Vickery, Brian P., additional, Vlieg‐Boerstra, Berber, additional, Werfel, Thomas, additional, Worm, Margitta, additional, Du Toit, George, additional, and Skypala, Isabel, additional

Published
2023
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14. Prevalence of tree nut allergy in Europe: A systematic review and meta‐analysis

Author

Spolidoro, Giulia C. I., primary, Lisik, Daniil, additional, Nyassi, Sungkutu, additional, Ioannidou, Athina, additional, Ali, Mohamed Mustafa, additional, Amera, Yohannes Tesfaye, additional, Rovner, Graciela, additional, Khaleva, Ekaterina, additional, Venter, Carina, additional, van Ree, Ronald, additional, Worm, Margitta, additional, Vlieg‐Boerstra, Berber, additional, Sheikh, Aziz, additional, Muraro, Antonella, additional, Roberts, Graham, additional, and Nwaru, Bright I., additional

Published
2023
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15. Prevalence estimates of eight big food allergies in Europe: Updated systematic review and meta‐analysis

Author

Spolidoro, Giulia C. I., primary, Ali, Mohamed Mustafa, additional, Amera, Yohannes Tesfaye, additional, Nyassi, Sungkutu, additional, Lisik, Daniil, additional, Ioannidou, Athina, additional, Rovner, Graciela, additional, Khaleva, Ekaterina, additional, Venter, Carina, additional, van Ree, Ronald, additional, Worm, Margitta, additional, Vlieg‐Boerstra, Berber, additional, Sheikh, Aziz, additional, Muraro, Antonella, additional, Roberts, Graham, additional, and Nwaru, Bright I., additional

Published
2023
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17. Prevalence of tree nut allergy in Europe: A systematic review and meta‐analysis.

Author

Spolidoro, Giulia C. I., Lisik, Daniil, Nyassi, Sungkutu, Ioannidou, Athina, Ali, Mohamed Mustafa, Amera, Yohannes Tesfaye, Rovner, Graciela, Khaleva, Ekaterina, Venter, Carina, van Ree, Ronald, Worm, Margitta, Vlieg‐Boerstra, Berber, Sheikh, Aziz, Muraro, Antonella, Roberts, Graham, and Nwaru, Bright I.

Subjects
FOOD allergy, ALMOND, HAZELNUTS, CLINICAL immunology, AGE groups
Abstract

In 2014, the European Academy of Allergy and Clinical Immunology (EAACI) published the first systematic review that summarized the prevalence of food allergy (FA) and food sensitization in Europe for studies published 2000–2012. However, only summary estimates for tree nut allergy (TNA) were feasible in that work. In the current update of that systematic review, we summarized the prevalence of tree nut allergy/sensitization to individual tree nuts. Six databases were searched for relevant papers published 2012–2021 and 17 eligible studies were added to the 15 studies already identified between 2000 and 2012, giving a total of 32 studies. Of the investigated tree nuts, meta‐analysis was possible for hazelnut, walnut, almond, and in few cases, for cashew, and Brazil nut. The lifetime self‐reported prevalence was 0.8% (95% CI 0.5–1.1) for hazelnut and 0.4% (0.2–0.9) for walnut. The point self‐reported prevalence was 4.0% (2.9–5.2) for hazelnut, 3.4% (2.0–4.9) for Brazil nut, 2.0% (1.1–2.9) for almond, and 1.8% (1.1–2.5) for walnut. Point prevalence of food challenge‐confirmed TNA was 0.04% (0.0–0.1) for hazelnut and 0.02% (0.01–0.1) for walnut. Due to paucity of data, we could not identify any meaningful and consistent differences across age groups and European regions. [ABSTRACT FROM AUTHOR]

Published
2024
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18. Peanut thresholds in peanut‐allergic children are related to dietary composition

Author

Luiten, Daisy, primary, Biezeveld, Maarten, additional, van Doorn, Olga, additional, Riady, Hanae, additional, Yang, Ming, additional, Bergsma, Femke, additional, van der Plas, Atie, additional, Brand, Kim, additional, Arends, Nicolette, additional, de Bruin, Annette, additional, de Vries, Jeanne, additional, de Meij, Tim, additional, and Vlieg‐Boerstra, Berber, additional

Published
2023
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19. Peanut thresholds in peanut-allergic children are related to dietary composition

Author

Luiten, Daisy, Biezeveld, Maarten, van Doorn, Olga, Riady, Hanae, Yang, Ming, Bergsma, Femke, van der Plas, Atie, Brand, Kim, Arends, Nicolette, de Bruin, Annette, de Vries, Jeanne, de Meij, Tim, Vlieg-Boerstra, Berber, Luiten, Daisy, Biezeveld, Maarten, van Doorn, Olga, Riady, Hanae, Yang, Ming, Bergsma, Femke, van der Plas, Atie, Brand, Kim, Arends, Nicolette, de Bruin, Annette, de Vries, Jeanne, de Meij, Tim, and Vlieg-Boerstra, Berber

Abstract

Background: There is no clear explanation for the large variation in threshold levels among peanut-allergic children. We hypothesized that diet composition can partly explain this variation in thresholds, as nutrients and foods influence the intestinal barrier function and microbiota. Aim: to explore the relationship between the threshold levels for peanut and nutritional intake and gut microbial composition in peanut-allergic children. Methods: In this explorative cross-sectional study the cumulative threshold levels for peanut were determined by oral food challenge tests. Data on nutrients and foods consumed were obtained from 3-day food diaries. Microbial composition of faeces and saliva were determined by molecular microbiota detection technique. Multivariable linear regression analysis and multiple logistic regression were used to explore the associations, adjusted for energy and senitization. Results: Sixty-five children were included, of whom 32 (49%) (median age 50 months, IQR 28.0–96.5) had a positive oral food challenge. Significant positive associations were found between the intake of total carbohydrates, vitamin A and cumulative threshold levels for peanut, while significant negative associations were found for long-chain polyunsaturated fatty acids, linoleic acid and omega-6 fatty acids. No associations were found between threshold levels and microbial composition of faeces and saliva. However, a significant higher abundance of Proteobacteria and Bacteroidetes in saliva (p = 0.011 and 0.04, respectively) and of Proteobacteria in faeces (p = 0.003) were found in children with a positive peanut challenge compared to children with a negative peanut challenge. Conclusion: As a novel concept, this study showed that dietary composition is related to threshold levels for peanut.

Published
2023

20. EAACI guidelines on the diagnosis of IgE-mediated food allergy

Author

CTI Research, MS Dermatologie/Allergologie, Infection & Immunity, Santos, Alexandra F, Riggioni, Carmen, Agache, Ioana, Akdis, Cezmi A, Akdis, Mubeccel, Alvarez-Perea, Alberto, Alvaro-Lozano, Montserrat, Ballmer-Weber, Barbara, Barni, Simona, Beyer, Kirsten, Bindslev-Jensen, Carsten, Brough, Helen A, Buyuktiryaki, Betul, Chu, Derek, Del Giacco, Stefano, Dunn-Galvin, Audrey, Eberlein, Bernadette, Ebisawa, Motohiro, Eigenmann, Philippe, Eiwegger, Thomas, Feeney, Mary, Fernandez-Rivas, Montserrat, Fisher, Helen R, Fleischer, David M, Giovannini, Mattia, Gray, Claudia, Hoffmann-Sommergruber, Karin, Halken, Susanne, Hourihane, Jonathan O'B, Jones, Christina J, Jutel, Marek, Knol, Edward, Konstantinou, George N, Lack, Gideon, Lau, Susanne, Marques Mejias, Andreina, Marchisotto, Mary Jane, Meyer, Rosan, Mortz, Charlotte G, Moya, Beatriz, Muraro, Antonella, Nilsson, Caroline, Lopes de Oliveira, Lucila Camargo, O'Mahony, Liam, Papadopoulos, Nikolaos G, Perrett, Kirsten, Peters, Rachel L, Podesta, Marcia, Poulsen, Lars K, Roberts, Graham, Sampson, Hugh A, Schwarze, Jürgen, Smith, Peter, Tham, Elizabeth Huiwen, Untersmayr, Eva, Van Ree, Ronald, Venter, Carina, Vickery, Brian P, Vlieg-Boerstra, Berber, Werfel, Thomas, Worm, Margitta, Du Toit, George, Skypala, Isabel, CTI Research, MS Dermatologie/Allergologie, Infection & Immunity, Santos, Alexandra F, Riggioni, Carmen, Agache, Ioana, Akdis, Cezmi A, Akdis, Mubeccel, Alvarez-Perea, Alberto, Alvaro-Lozano, Montserrat, Ballmer-Weber, Barbara, Barni, Simona, Beyer, Kirsten, Bindslev-Jensen, Carsten, Brough, Helen A, Buyuktiryaki, Betul, Chu, Derek, Del Giacco, Stefano, Dunn-Galvin, Audrey, Eberlein, Bernadette, Ebisawa, Motohiro, Eigenmann, Philippe, Eiwegger, Thomas, Feeney, Mary, Fernandez-Rivas, Montserrat, Fisher, Helen R, Fleischer, David M, Giovannini, Mattia, Gray, Claudia, Hoffmann-Sommergruber, Karin, Halken, Susanne, Hourihane, Jonathan O'B, Jones, Christina J, Jutel, Marek, Knol, Edward, Konstantinou, George N, Lack, Gideon, Lau, Susanne, Marques Mejias, Andreina, Marchisotto, Mary Jane, Meyer, Rosan, Mortz, Charlotte G, Moya, Beatriz, Muraro, Antonella, Nilsson, Caroline, Lopes de Oliveira, Lucila Camargo, O'Mahony, Liam, Papadopoulos, Nikolaos G, Perrett, Kirsten, Peters, Rachel L, Podesta, Marcia, Poulsen, Lars K, Roberts, Graham, Sampson, Hugh A, Schwarze, Jürgen, Smith, Peter, Tham, Elizabeth Huiwen, Untersmayr, Eva, Van Ree, Ronald, Venter, Carina, Vickery, Brian P, Vlieg-Boerstra, Berber, Werfel, Thomas, Worm, Margitta, Du Toit, George, and Skypala, Isabel

Published
2023

21. EAACI guidelines on the diagnosis of IgE-mediated food allergy

Author

Santos, Alexandra F, Riggioni, Carmen, Agache, Ioana, Akdis, Cezmi A, Akdis, Mubeccel, Alvarez-Perea, Alberto, Alvaro-Lozano, Montserrat, Ballmer-Weber, Barbara, Barni, Simona, Beyer, Kirsten, Bindslev-Jensen, Carsten, Brough, Helen A, Buyuktiryaki, Betul, Chu, Derek, Del Giacco, Stefano, Dunn-Galvin, Audrey, Eberlein, Bernadette, Ebisawa, Motohiro, Eigenmann, Philippe, Eiwegger, Thomas, Feeney, Mary, Fernandez-Rivas, Montserrat, Fisher, Helen R, Fleischer, David M, Giovannini, Mattia, Gray, Claudia, Hoffmann-Sommergruber, Karin, Halken, Susanne, Hourihane, Jonathan O'B, Jones, Christina J, Jutel, Marek, Knol, Edward, Konstantinou, George N, Lack, Gideon, Lau, Susanne, Marques Mejias, Andreina, Marchisotto, Mary Jane, Meyer, Rosan, Mortz, Charlotte G, Moya, Beatriz, Muraro, Antonella, Nilsson, Caroline, Lopes de Oliveira, Lucila Camargo, O'Mahony, Liam, Papadopoulos, Nikolaos G, Perrett, Kirsten, Peters, Rachel L, Podesta, Marcia, Poulsen, Lars K, Roberts, Graham, Sampson, Hugh A, Schwarze, Jürgen, Smith, Peter, Tham, Elizabeth Huiwen, Untersmayr, Eva, Van Ree, Ronald, Venter, Carina, Vickery, Brian P, Vlieg-Boerstra, Berber, Werfel, Thomas, Worm, Margitta, Du Toit, George, Skypala, Isabel, Santos, Alexandra F, Riggioni, Carmen, Agache, Ioana, Akdis, Cezmi A, Akdis, Mubeccel, Alvarez-Perea, Alberto, Alvaro-Lozano, Montserrat, Ballmer-Weber, Barbara, Barni, Simona, Beyer, Kirsten, Bindslev-Jensen, Carsten, Brough, Helen A, Buyuktiryaki, Betul, Chu, Derek, Del Giacco, Stefano, Dunn-Galvin, Audrey, Eberlein, Bernadette, Ebisawa, Motohiro, Eigenmann, Philippe, Eiwegger, Thomas, Feeney, Mary, Fernandez-Rivas, Montserrat, Fisher, Helen R, Fleischer, David M, Giovannini, Mattia, Gray, Claudia, Hoffmann-Sommergruber, Karin, Halken, Susanne, Hourihane, Jonathan O'B, Jones, Christina J, Jutel, Marek, Knol, Edward, Konstantinou, George N, Lack, Gideon, Lau, Susanne, Marques Mejias, Andreina, Marchisotto, Mary Jane, Meyer, Rosan, Mortz, Charlotte G, Moya, Beatriz, Muraro, Antonella, Nilsson, Caroline, Lopes de Oliveira, Lucila Camargo, O'Mahony, Liam, Papadopoulos, Nikolaos G, Perrett, Kirsten, Peters, Rachel L, Podesta, Marcia, Poulsen, Lars K, Roberts, Graham, Sampson, Hugh A, Schwarze, Jürgen, Smith, Peter, Tham, Elizabeth Huiwen, Untersmayr, Eva, Van Ree, Ronald, Venter, Carina, Vickery, Brian P, Vlieg-Boerstra, Berber, Werfel, Thomas, Worm, Margitta, Du Toit, George, and Skypala, Isabel

Abstract

This European Academy of Allergy and Clinical Immunology guideline provides recommendations for diagnosing IgE-mediated food allergy and was developed using the Grading of Recommendations, Assessment, Development and Evaluations (GRADE) approach. Food allergy diagnosis starts with an allergy-focused clinical history followed by tests to determine IgE sensitization, such as serum allergen-specific IgE (sIgE) and skin prick test (SPT), and the basophil activation test (BAT), if available. Evidence for IgE sensitization should be sought for any suspected foods. The diagnosis of allergy to some foods, such as peanut and cashew nut, is well supported by SPT and serum sIgE, whereas there are less data and the performance of these tests is poorer for other foods, such as wheat and soya. The measurement of sIgE to allergen components such as Ara h 2 from peanut, Cor a 14 from hazelnut and Ana o 3 from cashew can be useful to further support the diagnosis, especially in pollen-sensitized individuals. BAT to peanut and sesame can be used additionally. The reference standard for food allergy diagnosis is the oral food challenge (OFC). OFC should be performed in equivocal cases. For practical reasons, open challenges are suitable in most cases. Reassessment of food allergic children with allergy tests and/or OFCs periodically over time will enable reintroduction of food into the diet in the case of spontaneous acquisition of oral tolerance.

Published
2023

22. The immune‐supportive diet in allergy management. A narrative review and proposal

Author

Vlieg‐Boerstra, Berber, primary, Groetch, Marion, additional, Vassilopoulou, Emilia, additional, Meyer, Rosan, additional, Laitinen, Kirsi, additional, Swain, Anne, additional, Durban, Raquel, additional, Benjamin, Olga, additional, Bottse, Rachelle, additional, Grimshaw, Kate, additional, Netting, Merryn, additional, O’Manony, Liam, additional, de Jong, Nicolette, additional, and Skypala, Isabel J., additional

Published
2023
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23. Frequency of food allergy in Europe: an updated systematic review and meta-analysis

Author

Spolidoro, Giulia C.I., Tesfaye Amera, Yohannes, Ali, Mohamed Mustafa, Nyassi, Sungkutu, Lisik, Daniil, Ioannidou, Athina, Rovner, Graciela, Khaleva, Ekaterina, Venter, Carina, van Ree, Ronald, Worm, Margitta, Vlieg-Boerstra, Berber, Sheikh, Aziz, Muraro, Antonella, Roberts, Graham, and Nwaru, Bright I

Abstract

Food allergy (FA) is increasingly reported in Europe, however the latest prevalence estimates were based on studies published a decade ago. The present work provides the most updated estimates of the prevalence and trends of FA in Europe. Databases were searched for studies published between 2012 and 2021, added to studies published up to 2012. In total, 110 studies were included in this update. Most studies were graded as moderate risk of bias. Pooled lifetime and point prevalence of self-reported FA were 19.9% (95% CI 16.6-23.3) and 13.1% (95% CI 11.3-14.8), respectively. The point prevalence of sensitization based on specific IgE (slgE) was 16.6% (95% CI 12.3-20.8), skin prick test (SPT) 5.7% (95% CI 3.9-7.4), and positive food challenge 0.8% (95% CI 0.5-0.9). While lifetime prevalence of self-reported FA and food challenge positivity only slightly changed, the point prevalence of self-reported FA, sIgE and SPT positivity increased from previous estimates. This may reflect a real increase, increased awareness, increased number of foods assessed, or increased number of studies from countries with less data in the first review. Future studies require rigorous designs and implementation of standardized methodology in diagnosing FA, including use of double-blinded placebo-controlled food challenge to minimize potential biases.

Published
2022

24. Frequency of food allergy in Europe: An updated systematic review and meta‐analysis

Author

Spolidoro, Giulia C. I., primary, Amera, Yohannes Tesfaye, additional, Ali, Mohamed Mustafa, additional, Nyassi, Sungkutu, additional, Lisik, Daniil, additional, Ioannidou, Athina, additional, Rovner, Graciela, additional, Khaleva, Ekaterina, additional, Venter, Carina, additional, van Ree, Ronald, additional, Worm, Margitta, additional, Vlieg‐Boerstra, Berber, additional, Sheikh, Aziz, additional, Muraro, Antonella, additional, Roberts, Graham, additional, and Nwaru, Bright I., additional

Published
2022
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25. Managing food allergy: GA2LEN guideline 2022

Author

Muraro, Antonella, primary, de Silva, Debra, additional, Halken, Susanne, additional, Worm, Margitta, additional, Khaleva, Ekaterina, additional, Arasi, Stefania, additional, Dunn-Galvin, Audrey, additional, Nwaru, Bright I., additional, De Jong, Nicolette W., additional, Rodríguez Del Río, Pablo, additional, Turner, Paul J., additional, Smith, Pete, additional, Begin, Philippe, additional, Angier, Elizabeth, additional, Arshad, Hasan, additional, Ballmer-Weber, Barbara, additional, Beyer, Kirsten, additional, Bindslev-Jensen, Carsten, additional, Cianferoni, Antonella, additional, Demoulin, Céline, additional, Deschildre, Antoine, additional, Ebisawa, Motohiro, additional, Fernandez-Rivas, Maria Montserrat, additional, Fiocchi, Alessandro, additional, Flokstra-de Blok, Bertine, additional, Gerdts, Jennifer, additional, Gradman, Josefine, additional, Grimshaw, Kate, additional, Jones, Carla, additional, Lau, Susanne, additional, Loh, Richard, additional, Alvaro Lozano, Montserrat, additional, Makela, Mika, additional, Marchisotto, Mary Jane, additional, Meyer, Rosan, additional, Mills, Clare, additional, Nilsson, Caroline, additional, Nowak-Wegrzyn, Anna, additional, Nurmatov, Ulugbek, additional, Pajno, Giovanni, additional, Podestà, Marcia, additional, Poulsen, Lars K., additional, Sampson, Hugh A., additional, Sanchez, Angel, additional, Schnadt, Sabine, additional, Szajewska, Hania, additional, Van Ree, Ronald, additional, Venter, Carina, additional, Vlieg-Boerstra, Berber, additional, Warner, Amena, additional, Wong, Gary, additional, Wood, Robert, additional, Zuberbier, Torsten, additional, Roberts, Graham, additional, Bansal, Priya, additional, Berni–Canani, Roberto, additional, Blumchen, Katharina, additional, Bonertz, Andreas, additional, Bourgoin-Heck, Melisande, additional, Ceylon, Ozlem, additional, Divaret-Chauveau, Amandine, additional, Fleischer, David, additional, Gomez, Maximiliano, additional, Groetch, Marion, additional, Hernandez, Domingo Barber, additional, Hjorth, Betina, additional, Hussey, Lydia Collins, additional, Knulst, André C., additional, Leung, Agnes, additional, Mack, Douglas, additional, Mahler, Vera, additional, Mori, Francesca, additional, Namazova-Baranova, Leyla, additional, Palosuo, Kati, additional, Parisi, Claudio Alberto Salvador, additional, Pastorino, Antonio Carlos, additional, Rudzeviciene, Odilija, additional, Said, Maria, additional, Sawiec, Piotr, additional, Sicherer, Scott, additional, Sato, Sakura, additional, and Zubchenko, Svitlana, additional

Published
2022
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26. Role of dietary fiber in promoting immune health—An EAACI position paper

Author

Venter, Carina, primary, Meyer, Rosan W., additional, Greenhawt, Matthew, additional, Pali‐Schöll, Isabella, additional, Nwaru, Bright, additional, Roduit, Caroline, additional, Untersmayr, Eva, additional, Adel‐Patient, Karine, additional, Agache, Ioana, additional, Agostoni, Carlo, additional, Akdis, Cezmi A., additional, Feeney, Mary, additional, Hoffmann‐Sommergruber, Karin, additional, Lunjani, Nonhlanhla, additional, Grimshaw, Kate, additional, Reese, Imke, additional, Smith, Peter K., additional, Sokolowska, Milena, additional, Vassilopoulou, Emilia, additional, Vlieg‐Boerstra, Berber, additional, Amara, Shriya, additional, Walter, Jens, additional, and O'Mahony, Liam, additional

Published
2022
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27. Prevalence of sensitization to molecular food allergens in Europe: A systematic review

Author

Lisik, Daniil, primary, Ioannidou, Athina, additional, Spolidoro, Giulia, additional, Ali, Mohamed, additional, Nyassi, Sungkutu, additional, Amera, Yohanes, additional, Rovner, Graciela, additional, Khaleva, Ekaterina, additional, Venter, Carina, additional, van Ree, Ronald, additional, Worm, Margitta, additional, Vlieg‐Boerstra, Berber, additional, Sheikh, Aziz, additional, Muraro, Antonella, additional, Roberts, Graham, additional, and Nwaru, Bright I., additional

Published
2022
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28. A healthier daily diet is associated with greater immune fitness

Author

Afd Pharmacology, Pharmacology, van Oostrom, Evi C., Mulder, Kiki EW, Verheul, Marjolijn CE, Hendriksen, Pauline A., Thijssen, Suzan, Kraneveld, Aletta D., Vlieg-Boerstra, Berber, Garssen, Johan, Verster, Joris C., Afd Pharmacology, Pharmacology, van Oostrom, Evi C., Mulder, Kiki EW, Verheul, Marjolijn CE, Hendriksen, Pauline A., Thijssen, Suzan, Kraneveld, Aletta D., Vlieg-Boerstra, Berber, Garssen, Johan, and Verster, Joris C.

Published
2022

29. Development of a core outcome set for therapeutic studies in eosinophilic esophagitis (COREOS)

Author

Ma, Christopher, Schoepfer, Alain M., Dellon, Evan S., Bredenoord, Albert J., Chehade, Mirna, Collins, Margaret H., Feagan, Brian G., Furuta, Glenn T., Gupta, Sandeep K., Hirano, Ikuo, Jairath, Vipul, Katzka, David A., Pai, Rish K., Rothenberg, Marc E., Straumann, Alex, Aceves, Seema S., Alexander, Jeffrey A., Arva, Nicoleta C., Atkins, Dan, Biedermann, Luc, Blanchard, Carine, Cianferoni, Antonella, Ciriza de los Rios, Constanza, Clayton, Frederic, Davis, Carla M., de Bortoli, Nicola, Dias, Jorge A., Falk, Gary W., Genta, Robert M., Ghaffari, Gisoo, Gonsalves, Nirmala, Greuter, Thomas, Hopp, Russell, Hsu Blatman, Karen S., Jensen, Elizabeth T., Johnston, Doug, Kagalwalla, Amir F., Larsson, Helen M., Leung, John, Louis, Hubert, Masterson, Joanne C., Menard-Katcher, Calies, Menard-Katcher, Paul A., Moawad, Fouad J., Muir, Amanda B., Mukkada, Vincent A., Penagini, Roberto, Pesek, Robert D., Peterson, Kathryn, Putnam, Philip E., Ravelli, Alberto, Savarino, Edoardo V., Schlag, Christoph, Schreiner, Philipp, Simon, Dagmar, Smyrk, Thomas C., Spergel, Jonathan M., Taft, Tiffany H., Terreehorst, Ingrid, Vanuytsel, Tim, Venter, Carina, Vieira, Mario C., Vieth, Michael, Vlieg-Boerstra, Berber, von Arnim, Ulrike, Walker, Marjorie M., Wechsler, Joshua B., Woodland, Philip, Woosley, John T., Yang, Guang-Yu, Zevit, Noam, Safroneeva, Ekaterina, Ma, Christopher, Schoepfer, Alain M., Dellon, Evan S., Bredenoord, Albert J., Chehade, Mirna, Collins, Margaret H., Feagan, Brian G., Furuta, Glenn T., Gupta, Sandeep K., Hirano, Ikuo, Jairath, Vipul, Katzka, David A., Pai, Rish K., Rothenberg, Marc E., Straumann, Alex, Aceves, Seema S., Alexander, Jeffrey A., Arva, Nicoleta C., Atkins, Dan, Biedermann, Luc, Blanchard, Carine, Cianferoni, Antonella, Ciriza de los Rios, Constanza, Clayton, Frederic, Davis, Carla M., de Bortoli, Nicola, Dias, Jorge A., Falk, Gary W., Genta, Robert M., Ghaffari, Gisoo, Gonsalves, Nirmala, Greuter, Thomas, Hopp, Russell, Hsu Blatman, Karen S., Jensen, Elizabeth T., Johnston, Doug, Kagalwalla, Amir F., Larsson, Helen M., Leung, John, Louis, Hubert, Masterson, Joanne C., Menard-Katcher, Calies, Menard-Katcher, Paul A., Moawad, Fouad J., Muir, Amanda B., Mukkada, Vincent A., Penagini, Roberto, Pesek, Robert D., Peterson, Kathryn, Putnam, Philip E., Ravelli, Alberto, Savarino, Edoardo V., Schlag, Christoph, Schreiner, Philipp, Simon, Dagmar, Smyrk, Thomas C., Spergel, Jonathan M., Taft, Tiffany H., Terreehorst, Ingrid, Vanuytsel, Tim, Venter, Carina, Vieira, Mario C., Vieth, Michael, Vlieg-Boerstra, Berber, von Arnim, Ulrike, Walker, Marjorie M., Wechsler, Joshua B., Woodland, Philip, Woosley, John T., Yang, Guang-Yu, Zevit, Noam, and Safroneeva, Ekaterina

Abstract

Background: End points used to determine treatment efficacy in eosinophilic esophagitis (EoE) have evolved over time. With multiple novel therapies in development for EoE, harmonization of outcomes measures will facilitate evidence synthesis and appraisal when comparing different treatments. Objective: We sought to develop a core outcome set (COS) for controlled and observational studies of pharmacologic and diet interventions in adult and pediatric patients with EoE. Methods: Candidate outcomes were generated from systematic literature reviews and patient engagement interviews and surveys. Consensus was established using an iterative Delphi process, with items voted on using a 9-point Likert scale and with feedback from other participants to allow score refinement.

Published
2022

30. Managing food allergy:GA2LEN guideline 2022

Author

Muraro, Antonella, de Silva, Debra, Halken, Susanne, Worm, Margitta, Khaleva, Ekaterina, Arasi, Stefania, Dunn-Galvin, Audrey, Nwaru, Bright I., De Jong, Nicolette W., Rodríguez Del Río, Pablo, Turner, Paul J., Smith, Pete, Begin, Philippe, Angier, Elizabeth, Arshad, Hasan, Ballmer-Weber, Barbara, Beyer, Kirsten, Bindslev-Jensen, Carsten, Cianferoni, Antonella, Demoulin, Céline, Deschildre, Antoine, Ebisawa, Motohiro, Fernandez-Rivas, Maria Montserrat, Fiocchi, Alessandro, Flokstra-de Blok, Bertine, Gerdts, Jennifer, Gradman, Josefine, Grimshaw, Kate, Jones, Carla, Lau, Susanne, Loh, Richard, Alvaro Lozano, Montserrat, Makela, Mika, Marchisotto, Mary Jane, Meyer, Rosan, Mills, Clare, Nilsson, Caroline, Nowak-Wegrzyn, Anna, Nurmatov, Ulugbek, Pajno, Giovanni, Podestà, Marcia, Poulsen, Lars K., Sampson, Hugh A., Sanchez, Angel, Schnadt, Sabine, Szajewska, Hania, Van Ree, Ronald, Venter, Carina, Vlieg-Boerstra, Berber, Warner, Amena, Zuberbier, Torsten, Roberts, Graham, Muraro, Antonella, de Silva, Debra, Halken, Susanne, Worm, Margitta, Khaleva, Ekaterina, Arasi, Stefania, Dunn-Galvin, Audrey, Nwaru, Bright I., De Jong, Nicolette W., Rodríguez Del Río, Pablo, Turner, Paul J., Smith, Pete, Begin, Philippe, Angier, Elizabeth, Arshad, Hasan, Ballmer-Weber, Barbara, Beyer, Kirsten, Bindslev-Jensen, Carsten, Cianferoni, Antonella, Demoulin, Céline, Deschildre, Antoine, Ebisawa, Motohiro, Fernandez-Rivas, Maria Montserrat, Fiocchi, Alessandro, Flokstra-de Blok, Bertine, Gerdts, Jennifer, Gradman, Josefine, Grimshaw, Kate, Jones, Carla, Lau, Susanne, Loh, Richard, Alvaro Lozano, Montserrat, Makela, Mika, Marchisotto, Mary Jane, Meyer, Rosan, Mills, Clare, Nilsson, Caroline, Nowak-Wegrzyn, Anna, Nurmatov, Ulugbek, Pajno, Giovanni, Podestà, Marcia, Poulsen, Lars K., Sampson, Hugh A., Sanchez, Angel, Schnadt, Sabine, Szajewska, Hania, Van Ree, Ronald, Venter, Carina, Vlieg-Boerstra, Berber, Warner, Amena, Zuberbier, Torsten, and Roberts, Graham

Abstract

Food allergy affects approximately 2–4% of children and adults. This guideline provides recommendations for managing food allergy from the Global Allergy and Asthma European Network (GA2LEN). A multidisciplinary international Task Force developed the guideline using the Appraisal of Guidelines for Research and Evaluation (AGREE) II framework and the Grading of Recommendations, Assessment, Development and Evaluations (GRADE) approach. We reviewed the latest available evidence as of April 2021 (161 studies) and created recommendations by balancing benefits, harms, feasibility, and patient and clinician experiences. We suggest that people diagnosed with food allergy avoid triggering allergens (low certainty evidence). We suggest that infants with cow's milk allergy who need a breastmilk alternative use either hypoallergenic extensively hydrolyzed cow's milk formula or an amino acid-based formula (moderate certainty). For selected children with peanut allergy, we recommend oral immunotherapy (high certainty), though epicutaneous immunotherapy might be considered depending on individual preferences and availability (moderate certainty). We suggest considering oral immunotherapy for children with persistent severe hen's egg or cow's milk allergy (moderate certainty). There are significant gaps in evidence about safety and effectiveness of the various strategies. Research is needed to determine the best approaches to education, how to predict the risk of severe reactions, whether immunotherapy is cost-effective and whether biological therapies are effective alone or combined with allergen immunotherapy.

Published
2022

31. EAACI guideline:Anaphylaxis (2021 update)

Author

Muraro, Antonella, Worm, Margitta, Alviani, Cherry, Cardona, Victoria, DunnGalvin, Audrey, Garvey, Lene H., Riggioni, Carmen, Silva, Debra de, Angier, Elizabeth, Arasi, Stefania, Bellou, Abdelouahab, Beyer, Kirsten, Bijlhout, Diola, Bilò, M. Beatrice, Bindslev-Jensen, Carsten, Brockow, Knut, Fernandez-Rivas, Montserrat, Halken, Susanne, Jensen, Britt, Khaleva, Ekaterina, Michaelis, Louise J., Elberink, Hanneke N. G. Oude, Regent, Lynne, Sanchez, Angel, Vlieg-Boerstra, Berber J., Roberts, Graham, Muraro, Antonella, Worm, Margitta, Alviani, Cherry, Cardona, Victoria, DunnGalvin, Audrey, Garvey, Lene H., Riggioni, Carmen, Silva, Debra de, Angier, Elizabeth, Arasi, Stefania, Bellou, Abdelouahab, Beyer, Kirsten, Bijlhout, Diola, Bilò, M. Beatrice, Bindslev-Jensen, Carsten, Brockow, Knut, Fernandez-Rivas, Montserrat, Halken, Susanne, Jensen, Britt, Khaleva, Ekaterina, Michaelis, Louise J., Elberink, Hanneke N. G. Oude, Regent, Lynne, Sanchez, Angel, Vlieg-Boerstra, Berber J., and Roberts, Graham

Abstract

Anaphylaxis is a clinical emergency which all healthcare professionals need to be able to recognise and manage. The European Academy of Allergy and Clinical Immunology Anaphylaxis multidisciplinary Task Force has updated the 2014 guideline. The guideline was developed using the AGREE II framework and the GRADE approach. The evidence was systematically reviewed and recommendations were created by weighing up benefits and harms. The guideline was peer-reviewed by external experts and reviewed in a public consultation. The use of clinical criteria to identify anaphylaxis is suggested with blood sampling for the later measurement of tryptase. The prompt use of intramuscular adrenaline as first line management is recommended with the availability of adrenaline autoinjectors to patients in the community. Pharmacokinetic data should be provided for adrenaline autoinjector devices. Structured, comprehensive training for people at risk of anaphylaxis is recommended. Simulation training and visual prompts for healthcare professionals are suggested to improve the management of anaphylaxis. It is suggested that school policies reflect anaphylaxis guidelines. The evidence for the management of anaphylaxis remains mostly at a very low level. There is an urgent need to prioritise clinical trials with the potential to improve the management of patients at risk of anaphylaxis., Anaphylaxis is a clinical emergency which all healthcare professionals need to be able to recognize and manage. The European Academy of Allergy and Clinical Immunology Anaphylaxis multidisciplinary Task Force has updated the 2014 guideline. The guideline was developed using the AGREE II framework and the GRADE approach. The evidence was systematically reviewed and recommendations were created by weighing up benefits and harms. The guideline was peer-reviewed by external experts and reviewed in a public consultation. The use of clinical criteria to identify anaphylaxis is suggested with blood sampling for the later measurement of tryptase. The prompt use of intramuscular adrenaline as first-line management is recommended with the availability of adrenaline autoinjectors to patients in the community. Pharmacokinetic data should be provided for adrenaline autoinjector devices. Structured, comprehensive training for people at risk of anaphylaxis is recommended. Simulation training and visual prompts for healthcare professionals are suggested to improve the management of anaphylaxis. It is suggested that school policies reflect anaphylaxis guidelines. The evidence for the management of anaphylaxis remains mostly at a very low level. There is an urgent need to prioritize clinical trials with the potential to improve the management of patients at risk of anaphylaxis.

Published
2022

32. 'Too high, too low': the complexities of using thresholds in isolation to inform precautionary allergen ('may contain') labels

Author

Turner, Paul J, Baumert, Joseph L, Beyer, Kirsten, Brooke-Taylor, Simon, Comberiati, Pasquale, Crevel, René W R, Gerdts, Jennifer D, Gowland, M Hazel, Houben, Geert F, Hourihane, Jonathan O'B, Konstantinou, George N, La Vieille, Sébastien, Moya, Beatriz, Muraro, Antonella, Mills, E N Clare, Patel, Nandinee, Podestà, Marcia, Popping, Bert, Reese, Imke, Roberts, Graham, Said, Maria, Santos, Alexandra F, Schnadt, Sabine, Taylor, Steve L, Vlieg-Boerstra, Berber, and Remington, Benjamin C

Subjects
Anaphylaxis, eliciting dose, food allergy, precautionary allergen labelling, reference dose, thresholds, Allergy, EAACI Taskforce on Food allergen thresholds, Immunology, thresholds, reference dose, Allergens, Food Labeling, 1107 Immunology, Immunology and Allergy, Humans, Food Hypersensitivity
Published
2021

34. Development of a core outcome set for therapeutic studies in eosinophilic esophagitis (COREOS)

Author

Ma, Christopher, primary, Schoepfer, Alain M., additional, Dellon, Evan S., additional, Bredenoord, Albert J., additional, Chehade, Mirna, additional, Collins, Margaret H., additional, Feagan, Brian G., additional, Furuta, Glenn T., additional, Gupta, Sandeep K., additional, Hirano, Ikuo, additional, Jairath, Vipul, additional, Katzka, David A., additional, Pai, Rish K., additional, Rothenberg, Marc E., additional, Straumann, Alex, additional, Aceves, Seema S., additional, Alexander, Jeffrey A., additional, Arva, Nicoleta C., additional, Atkins, Dan, additional, Biedermann, Luc, additional, Blanchard, Carine, additional, Cianferoni, Antonella, additional, Ciriza de los Rios, Constanza, additional, Clayton, Frederic, additional, Davis, Carla M., additional, de Bortoli, Nicola, additional, Dias, Jorge A., additional, Falk, Gary W., additional, Genta, Robert M., additional, Ghaffari, Gisoo, additional, Gonsalves, Nirmala, additional, Greuter, Thomas, additional, Hopp, Russell, additional, Hsu Blatman, Karen S., additional, Jensen, Elizabeth T., additional, Johnston, Doug, additional, Kagalwalla, Amir F., additional, Larsson, Helen M., additional, Leung, John, additional, Louis, Hubert, additional, Masterson, Joanne C., additional, Menard-Katcher, Calies, additional, Menard-Katcher, Paul A., additional, Moawad, Fouad J., additional, Muir, Amanda B., additional, Mukkada, Vincent A., additional, Penagini, Roberto, additional, Pesek, Robert D., additional, Peterson, Kathryn, additional, Putnam, Philip E., additional, Ravelli, Alberto, additional, Savarino, Edoardo V., additional, Schlag, Christoph, additional, Schreiner, Philipp, additional, Simon, Dagmar, additional, Smyrk, Thomas C., additional, Spergel, Jonathan M., additional, Taft, Tiffany H., additional, Terreehorst, Ingrid, additional, Vanuytsel, Tim, additional, Venter, Carina, additional, Vieira, Mario C., additional, Vieth, Michael, additional, Vlieg-Boerstra, Berber, additional, von Arnim, Ulrike, additional, Walker, Marjorie M., additional, Wechsler, Joshua B., additional, Woodland, Philip, additional, Woosley, John T., additional, Yang, Guang-Yu, additional, Zevit, Noam, additional, and Safroneeva, Ekaterina, additional

Published
2022
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35. Introduction of Heated Cow’s Milk Protein in Challenge-Proven Cow’s Milk Allergic Children: The iAGE Study

Author

de Jong, Nicolette W., primary, van Splunter, Marloes E., additional, Emons, Joyce A. M., additional, Hettinga, Kasper A., additional, Gerth van Wijk, Roy, additional, Wichers, Harry J., additional, Savelkoul, Huub F. J., additional, Sprikkelman, Aline B., additional, van Neerven, R. J. Joost, additional, Liu, Liu, additional, van der Meulen, Gerbrich, additional, Herpertz, Irene, additional, Duijvestijn, Yvonne C. M., additional, Breukels, Mijke, additional, Brouwer, Marianne I., additional, Schilperoord, Jaap, additional, van Doorn, Olga, additional, Vlieg-Boerstra, Berber, additional, van den Berg, Jochum, additional, Pellis, Linette, additional, Terlouw, Severina, additional, Hendriks, Astrid I., additional, Schreurs, Marco W. J., additional, van Boven, Frank E., additional, and Arends, Nicolette J. T., additional

Published
2022
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37. Frequency of food allergy in Europe: An updated systematic review and meta‐analysis.

Author

Spolidoro, Giulia C. I., Amera, Yohannes Tesfaye, Ali, Mohamed Mustafa, Nyassi, Sungkutu, Lisik, Daniil, Ioannidou, Athina, Rovner, Graciela, Khaleva, Ekaterina, Venter, Carina, van Ree, Ronald, Worm, Margitta, Vlieg‐Boerstra, Berber, Sheikh, Aziz, Muraro, Antonella, Roberts, Graham, and Nwaru, Bright I.

Subjects
FOOD allergy, SKIN tests, DATABASE searching, IMMUNOGLOBULIN E
Abstract

Food allergy (FA) is increasingly reported in Europe, however, the latest prevalence estimates were based on studies published a decade ago. The present work provides the most updated estimates of the prevalence and trends of FA in Europe. Databases were searched for studies published between 2012 and 2021, added to studies published up to 2012. In total, 110 studies were included in this update. Most studies were graded as moderate risk of bias. Pooled lifetime and point prevalence of self‐reported FA were 19.9% (95% CI 16.6–23.3) and 13.1% (95% CI 11.3–14.8), respectively. The point prevalence of sensitization based on specific IgE (slgE) was 16.6% (95% CI 12.3–20.8), skin prick test (SPT) 5.7% (95% CI 3.9–7.4), and positive food challenge 0.8% (95% CI 0.5–0.9). While lifetime prevalence of self‐reported FA and food challenge positivity only slightly changed, the point prevalence of self‐reported FA, sIgE and SPT positivity increased from previous estimates. This may reflect a real increase, increased awareness, increased number of foods assessed, or increased number of studies from countries with less data in the first review. Future studies require rigorous designs and implementation of standardized methodology in diagnosing FA, including use of double‐blinded placebo‐controlled food challenge to minimize potential biases. [ABSTRACT FROM AUTHOR]

Published
2023
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38. Food allergy: Stakeholder perspectives on acceptable risk

Author

Madsen, Charlotte B., Crevel, René, Chan, Chun-Han, Dubois, Anthony E.J., DunnGalvin, Audrey, Flokstra-de Blok, Bertine M.J., Gowland, M. Hazel, Hattersley, Sue, Hourihane, Jonathan O’B, Nørhede, Pia, Pfaff, Sylvia, Rowe, Gene, Schnadt, Sabine, and Vlieg-Boerstra, Berber J.

Published
2010
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40. A multi‐disciplinary approach to the diagnosis and management of allergic diseases: An EAACI Task Force

Author

Vassilopoulou, Emilia, primary, Skypala, Isabel, additional, Feketea, Gavriela, additional, Gawlik, Radoslaw, additional, Dunn Galvin, Audrey, additional, Meyer, Rosan, additional, Pitsios, Constantinos, additional, Maria Pop, Raluca, additional, Ryan, Dermot, additional, Said, Maria, additional, Scheire, Sophie, additional, Vlieg‐Boerstra, Berber, additional, and Kull, Inger, additional

Published
2021
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41. Nutrient supplementation for prevention of viral respiratory tract infections in healthy subjects: A systematic review and meta‐analysis

Author

Vlieg‐ Boerstra, Berber, primary, de Jong, Nicolette, additional, Meyer, Rosan, additional, Agostoni, Carlo, additional, De Cosmi, Valentina, additional, Grimshaw, Kate, additional, Milani, Gregorio Paolo, additional, Muraro, Antonella, additional, Oude Elberink, Hanneke, additional, Pali‐ Schöll, Isabella, additional, Roduit, Caroline, additional, Sasaki, Mari, additional, Skypala, Isabel, additional, Sokolowska, Milena, additional, van Splunter, Marloes, additional, Untersmayr, Eva, additional, Venter, Carina, additional, O’Mahony, Liam, additional, and Nwaru, Bright I, additional

Published
2021
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42. Development of a Core Outcome Set for Therapeutic Studies in Eosinophilic Esophagitis (COREOS): An International Multidisciplinary Consensus

Author

Ma, Christopher, primary, Schoepfer, Alain M., additional, Safroneeva, Ekaterina, additional, Ma, Christopher, additional, Dellon, Evan S., additional, Bredenoord, Albert J., additional, Chehade, Mirna, additional, Collins, Margaret H., additional, Feagan, Brian G., additional, Furuta, Glenn T., additional, Gupta, Sandeep K., additional, Hirano, Ikuo, additional, Jairath, Vipul, additional, Katzka, David A., additional, Pai, Rish K., additional, Rothenberg, Marc E., additional, Straumann, Alex, additional, Aceves, Seema S., additional, Alexander, Jeffrey A., additional, Arva, Nicoleta C., additional, Atkins, Dan, additional, Biedermann, Luc, additional, Blanchard, Carine, additional, Cianferoni, Antonella, additional, Ciriza de los Rios, Constanza, additional, Clayton, Frederic, additional, Davis, Carla M., additional, de Bortoli, Nicola, additional, Dias, Jorge A., additional, Falk, Gary W., additional, Genta, Robert M., additional, Ghaffari, Gisoo, additional, Gonsalves, Nirmala, additional, Greuter, Thomas, additional, Hopp, Russell, additional, Hsu Blatman, Karen S., additional, Jensen, Elizabeth T., additional, Johnston, Doug, additional, Kagalwalla, Amir F., additional, Larsson, Helen M., additional, Leung, John, additional, Louis, Hubert, additional, Masterson, Joanne C., additional, Menard-Katcher, Calies, additional, Menard-Katcher, Paul A., additional, Moawad, Fouad J., additional, Muir, Amanda B., additional, Mukkada, Vincent A., additional, Penagini, Roberto, additional, Pesek, Robert D., additional, Peterson, Kathryn, additional, Putnam, Philip E., additional, Ravelli, Alberto, additional, Savarino, Edoardo V., additional, Schlag, Christoph, additional, Schreiner, Philipp, additional, Simon, Dagmar, additional, Smyrk, Thomas C., additional, Spergel, Jonathan M., additional, Taft, Tiffany H., additional, Terreehorst, Ingrid, additional, Vanuytsel, Tim, additional, Venter, Carina, additional, Vieira, Mario C., additional, Vieth, Michael, additional, Vlieg-Boerstra, Berber, additional, von Arnim, Ulrike, additional, Walker, Marjorie M., additional, Wechsler, Joshua B., additional, Woodland, Philip, additional, Woosley, John T., additional, Yang, Guang-Yu, additional, and Zevit, Noam, additional

Published
2021
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43. A Summary of the Meetings of the Development of a Core Outcome Set for Therapeutic Studies in Eosinophilic Esophagitis (COREOS) International Multidisciplinary Consensus

Author

Ma, Christopher, primary, Schoepfer, Alain M., additional, Safroneeva, Ekaterina, additional, Ma, Christopher, additional, Dellon, Evan S., additional, Bredenoord, Albert J., additional, Chehade, Mirna, additional, Collins, Margaret H., additional, Feagan, Brian G., additional, Furuta, Glenn T., additional, Gupta, Sandeep K., additional, Hirano, Ikuo, additional, Jairath, Vipul, additional, Katzka, David A., additional, Pai, Rish K., additional, Rothenberg, Marc E., additional, Straumann, Alex, additional, Aceves, Seema S., additional, Alexander, Jeffrey A., additional, Arva, Nicoleta C., additional, Atkins, Dan, additional, Biedermann, Luc, additional, Blanchard, Carine, additional, Cianferoni, Antonella, additional, Ciriza de los Rios, Constanza, additional, Clayton, Frederic, additional, Davis, Carla M., additional, de Bortoli, Nicola, additional, Dias, Jorge A., additional, Falk, Gary W., additional, Genta, Robert M., additional, Ghaffari, Gisoo, additional, Gonsalves, Nirmala, additional, Greuter, Thomas, additional, Hopp, Russell, additional, Hsu Blatman, Karen S., additional, Jensen, Elizabeth T., additional, Johnston, Doug, additional, Kagalwalla, Amir F., additional, Larsson, Helen M., additional, Leung, John, additional, Louis, Hubert, additional, Masterson, Joanne C., additional, Menard-Katcher, Calies, additional, Menard-Katcher, Paul A., additional, Moawad, Fouad J., additional, Muir, Amanda B., additional, Mukkada, Vincent A., additional, Penagini, Roberto, additional, Pesek, Robert D., additional, Peterson, Kathryn, additional, Putnam, Philip E., additional, Ravelli, Alberto, additional, Savarino, Edoardo V., additional, Schlag, Christoph, additional, Schreiner, Philipp, additional, Simon, Dagmar, additional, Smyrk, Thomas C., additional, Spergel, Jonathan M., additional, Taft, Tiffany H., additional, Terreehorst, Ingrid, additional, Vanuytsel, Tim, additional, Venter, Carina, additional, Vieira, Mario C., additional, Vieth, Michael, additional, Vlieg-Boerstra, Berber, additional, von Arnim, Ulrike, additional, Walker, Marjorie M., additional, Wechsler, Joshua B., additional, Woodland, Philip, additional, Woosley, John T., additional, Yang, Guang-Yu, additional, and Zevit, Noam, additional

Published
2021
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44. A Summary of the Meetings of the Development of a Core Outcome Set for Therapeutic Studies in Eosinophilic Esophagitis (COREOS) International Multidisciplinary Consensus

Author

Ma, Christopher, Schoepfer, Alain M., Safroneeva, Ekaterina, Dellon, Evan S., Bredenoord, Albert J., Chehade, Mirna, Collins, Margaret H., Feagan, Brian G., Furuta, Glenn T., Gupta, Sandeep K., Hirano, Ikuo, Jairath, Vipul, Katzka, David A., Pai, Rish K., Rothenberg, Marc E., Straumann, Alex, Aceves, Seema S., Alexander, Jeffrey A., Arva, Nicoleta C., Atkins, Dan, Biedermann, Luc, Blanchard, Carine, Cianferoni, Antonella, Ciriza de los Rios, Constanza, Clayton, Frederic, Davis, Carla M., de Bortoli, Nicola, Dias, Jorge A., Falk, Gary W., Genta, Robert M., Ghaffari, Gisoo, Gonsalves, Nirmala, Greuter, Thomas, Hopp, Russell, Hsu Blatman, Karen S., Jensen, Elizabeth T., Johnston, Doug, Kagalwalla, Amir F., Larsson, Helen M., Leung, John, Louis, Hubert, Masterson, Joanne C., Menard-Katcher, Calies, Menard-Katcher, Paul A., Moawad, Fouad J., Muir, Amanda B., Mukkada, Vincent A., Penagini, Roberto, Pesek, Robert D., Peterson, Kathryn, Putnam, Philip E., Ravelli, Alberto, Savarino, Edoardo V., Schlag, Christoph, Schreiner, Philipp, Simon, Dagmar, Smyrk, Thomas C., Spergel, Jonathan M., Taft, Tiffany H., Terreehorst, Ingrid, Vanuytsel, Tim, Venter, Carina, Vieira, Mario C., Vieth, Michael, Vlieg-Boerstra, Berber, von Arnim, Ulrike, Walker, Marjorie M., Wechsler, Joshua B., Woodland, Philip, Woosley, John T., Yang, Guang-Yu, Zevit, Noam, Ma, Christopher, Schoepfer, Alain M., Safroneeva, Ekaterina, Dellon, Evan S., Bredenoord, Albert J., Chehade, Mirna, Collins, Margaret H., Feagan, Brian G., Furuta, Glenn T., Gupta, Sandeep K., Hirano, Ikuo, Jairath, Vipul, Katzka, David A., Pai, Rish K., Rothenberg, Marc E., Straumann, Alex, Aceves, Seema S., Alexander, Jeffrey A., Arva, Nicoleta C., Atkins, Dan, Biedermann, Luc, Blanchard, Carine, Cianferoni, Antonella, Ciriza de los Rios, Constanza, Clayton, Frederic, Davis, Carla M., de Bortoli, Nicola, Dias, Jorge A., Falk, Gary W., Genta, Robert M., Ghaffari, Gisoo, Gonsalves, Nirmala, Greuter, Thomas, Hopp, Russell, Hsu Blatman, Karen S., Jensen, Elizabeth T., Johnston, Doug, Kagalwalla, Amir F., Larsson, Helen M., Leung, John, Louis, Hubert, Masterson, Joanne C., Menard-Katcher, Calies, Menard-Katcher, Paul A., Moawad, Fouad J., Muir, Amanda B., Mukkada, Vincent A., Penagini, Roberto, Pesek, Robert D., Peterson, Kathryn, Putnam, Philip E., Ravelli, Alberto, Savarino, Edoardo V., Schlag, Christoph, Schreiner, Philipp, Simon, Dagmar, Smyrk, Thomas C., Spergel, Jonathan M., Taft, Tiffany H., Terreehorst, Ingrid, Vanuytsel, Tim, Venter, Carina, Vieira, Mario C., Vieth, Michael, Vlieg-Boerstra, Berber, von Arnim, Ulrike, Walker, Marjorie M., Wechsler, Joshua B., Woodland, Philip, Woosley, John T., Yang, Guang-Yu, and Zevit, Noam

Abstract

The Core Outcome Set for Therapeutic Studies in Eosinophilic Esophagitis (COREOS) collaborators are a group of more than 70 gastroenterologists, pathologists, allergists, researchers, dietitians, psychologists, and methodologists who convened in a series of in-person and virtual meetings between 2018 and 2020 with the aim of developing a core outcome set (COS) for use in therapeutic studies of pharmacologic and dietary therapies for the treatment of eosinophilic esophagitis (EoE). Given heterogeneity in reported outcomes and uncertainties regarding the most appropriate end points for use in both randomized controlled trials (RCTs) and observational studies involving EoE patients, the EoE experts launched the COREOS exercise in 2018 to standardize outcome definitions using methods established by the Core Outcome Measures in Effectiveness Trials (COMET) initiative.1,2 The COS was developed using a multiphase approach, which is summarized in Figure 1. In the first phase, systematic reviews of the literature and patient engagement surveys were conducted to identify candidate outcomes that have been previously measured and are important to patients with EoE. Next, this information was used to build a framework of different outcome domains, and working groups for each domain were assembled to review the literature for relevant end points.3–6 The relative importance of these domains was categorized in a Delphi survey as core, important, and research agenda domains, and discussed in a moderated in-person meeting on May 17, 2019 at Digestive Disease Week (San Diego, CA). In phase 3, a comprehensive list of outcome measures within each of the core domains was evaluated by the COREOS collaborators in a 2-round Delphi survey and, finally, outcomes were ratified in a virtual meeting on December 8, 2020. In this meeting summary, we highlight the major points of discussion that occurred during the development of the EoE COS.

Published
2021

45. The Habitual Diet of Dutch Adult Patients with Eosinophilic Esophagitis Has Pro-Inflammatory Properties and Low Diet Quality Scores

Author

De Kroon, Marlou, Eussen, Simone, Holmes, Bridget, Harthoorn, Lucien, Warners, Marijn, Bredenoord, Albert, Van Rhijn, Bram, Van Doorn, Mylene, Vlieg-Boerstra, Berber, De Kroon, Marlou, Eussen, Simone, Holmes, Bridget, Harthoorn, Lucien, Warners, Marijn, Bredenoord, Albert, Van Rhijn, Bram, Van Doorn, Mylene, and Vlieg-Boerstra, Berber

Abstract

We determined the nutritional adequacy and overall quality of the diets of adult patients with eosinophilic esophagitis (EoE). Dietary intakes stratified by sex and age were compared to Dietary Reference Values (DRV). Overall diet quality was assessed by two independent Diet-Quality-Indices scores, the PANDiet and DHD-index, and compared to age- and gender-matched subjects from the general population. Lastly, food and nutrient intakes of EoE patients were compared to intakes of the general population. Saturated fat intake was significantly higher and dietary fiber intake significantly lower than the DRV in both males and females. In males, the DRV were not reached for potassium, magnesium, selenium, and vitamins A and D. In females, the DRV were not reached for iron, sodium, potassium, selenium, and vitamins A, B2, C and D. EoE patients had a significantly lower PANDiet and DHD-index compared to the general population, although the relative intake (per 1000 kcal) of vegetables/fruits/olives was significantly higher (yet still up to 65% below the recommended daily amounts) and alcohol intake was significantly lower compared to the general Dutch population. In conclusion, the composition of the habitual diet of adult EoE patients has several pro-inflammatory and thus unfavorable immunomodulatory properties, just as the general Dutch population, and EoE patients had lower overall diet quality scores than the general population. Due to the observational character of this study, further research is needed to explore whether this contributes to the development and progression of EoE. View Full-Text

Published
2021

46. Diagnosing, managing and preventing anaphylaxis:Systematic review

Author

de Silva, Debra, Singh, Chris, Muraro, Antonella, Worm, Margitta, Alviani, Cherry, Cardona, Victoria, DunnGlvin, Audrey, Garvey, Lene Heise, Riggioni, Carmen, Angier, Elizabeth, Arasi, Stefania, Bellou, Abdelouahab, Beyer, Kirsten, Bijlhout, Diola, Bilo, M. Beatrice, Brockow, Knut, Fernandez-Rivas, Montserrat, Halken, Susanne, Jensen, Britt, Khaleva, Ekaterina, Michaelis, Louise J., Oude Elberink, Hanneke, Regent, Lynne, Sanchez, Angel, Vlieg-Boerstra, Berber, Roberts, Graham, de Silva, Debra, Singh, Chris, Muraro, Antonella, Worm, Margitta, Alviani, Cherry, Cardona, Victoria, DunnGlvin, Audrey, Garvey, Lene Heise, Riggioni, Carmen, Angier, Elizabeth, Arasi, Stefania, Bellou, Abdelouahab, Beyer, Kirsten, Bijlhout, Diola, Bilo, M. Beatrice, Brockow, Knut, Fernandez-Rivas, Montserrat, Halken, Susanne, Jensen, Britt, Khaleva, Ekaterina, Michaelis, Louise J., Oude Elberink, Hanneke, Regent, Lynne, Sanchez, Angel, Vlieg-Boerstra, Berber, and Roberts, Graham

Abstract

Background This systematic review used the GRADE approach to compile evidence to inform the European Academy of Allergy and Clinical Immunology's (EAACI) anaphylaxis guideline. Methods We searched five bibliographic databases from 1946 to 20 April 2020 for studies about the diagnosis, management and prevention of anaphylaxis. We included 50 studies with 18 449 participants: 29 randomized controlled trials, seven controlled clinical trials, seven consecutive case series and seven case-control studies. Findings were summarized narratively because studies were too heterogeneous to conduct meta-analysis. Results It is unclear whether the NIAID/FAAN criteria or Brighton case definition are valid for immediately diagnosing anaphylaxis due to the very low certainty of evidence. There was also insufficient evidence about the impact of most anaphylaxis management and prevention strategies. Adrenaline is regularly used for first-line emergency management of anaphylaxis but little robust research has assessed its effectiveness. Newer models of adrenaline autoinjectors may slightly increase the proportion of people correctly using the devices and reduce time to administration. Face-to-face training for laypeople may slightly improve anaphylaxis knowledge and competence in using autoinjectors. We searched for but found little or no comparative effectiveness evidence about strategies such as fluid replacement, oxygen, glucocorticosteroids, methylxanthines, bronchodilators, management plans, food labels, drug labels and similar. Conclusions Anaphylaxis is a potentially life-threatening condition but, due to practical and ethical challenges, there is a paucity of robust evidence about how to diagnose and manage it.

Published
2021

47. Effect of amino acid‐based formula added to four‐food elimination in adult eosinophilic esophagitis patients: A randomized clinical trial.

Author

de Rooij, Willemijn E., Vlieg – Boerstra, Berber, Warners, Marijn J., Van Ampting, Marleen T.J., van Esch, Betty C. A. M., Eussen, Simone R. B. M., and Bredenoord, Albert J.

Subjects
*EOSINOPHILIC esophagitis, *CLINICAL trials, *DIET therapy, *ELEMENTAL diet, *MEDITERRANEAN diet
Abstract

Background: Elimination of key foods restricts dietary options in eosinophilic esophagitis (EoE) patients. Addition of amino acid‐based formula (AAF) to an elimination diet might facilitate adherence and, therefore, enhance efficacy of dietary management. Aim: To evaluate whether addition of AAF to a four‐food elimination diet (FFED) is more effective than FFED alone in decreasing eosinophilia, endoscopic signs, and clinical outcomes. Methods: This randomized controlled trial enrolled 41 adult patients with active EoE (≥15 eosinophils (eos) per high power field (hpf)) at baseline biopsy. Subjects were randomized (1:1 ratio) to groups given a FFED or FFED with addition of AAF providing 30% of their daily energy needs (FFED + AAF). Histological disease activity, endoscopic signs, symptoms, and disease‐related quality of life (EoEQoL) were measured at baseline and after 6 weeks of intervention. Results: Patients (60% male, age 34.5 (interquartile range (IQR) 29–42.8 years)) were randomized to FFED (n = 20) or FFED + AAF (n = 21); 40 participants completed the diet. Complete histological remission (<15 eos/hpf) was achieved in 48% of FFED + AAF subjects (n = 21) vs. 25% of FFED subjects (n = 20), respectively (p = 0.204). Peak eosinophil counts (PEC) decreased significantly in both groups between baseline and week 6, but the change in PEC between groups was not different (p = 0.130). A significant but similar endoscopic and symptomatic reduction was observed in both groups (all; p<0.05). Total EoEQoL scores significantly improved in the FFED + AAF group between baseline and week 6 (p = 0.007), and not in the FFED group. Conclusion: The addition of AAF to a FFED did not lead to a larger decrease in PEC between baseline and 6 weeks, but may result in a significant improvement of QoL in adult EoE patients NL6014 (NTR6778). [ABSTRACT FROM AUTHOR]

Published
2022
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49. EAACI position paper on diet diversity in pregnancy, infancy and childhood:Novel concepts and implications for studies in allergy and asthma

Author

Venter, Carina, Greenhawt, Matthew, Meyer, Rosan W, Agostoni, Carlo, Reese, Imke, du Toit, George, Feeney, Mary, Maslin, Kate, Nwaru, Bright I, Roduit, Caroline, Untersmayr, Eva, Vlieg-Boerstra, Berber, Pali-Schöll, Isabella, Roberts, Graham C, Smith, Peter, Akdis, Cezmi A, Agache, Ioana, Ben-Adallah, Miriam, Bischoff, Stephan, Frei, Remo, Garn, Holger, Grimshaw, Kate, Hoffmann-Sommergruber, Karin, Lunjani, Nonhlanhla, Muraro, Antonella, Poulsen, Lars K., Renz, Harald, Sokolowska, Milena, Stanton, Catherine, O'Mahony, Liam, Venter, Carina, Greenhawt, Matthew, Meyer, Rosan W, Agostoni, Carlo, Reese, Imke, du Toit, George, Feeney, Mary, Maslin, Kate, Nwaru, Bright I, Roduit, Caroline, Untersmayr, Eva, Vlieg-Boerstra, Berber, Pali-Schöll, Isabella, Roberts, Graham C, Smith, Peter, Akdis, Cezmi A, Agache, Ioana, Ben-Adallah, Miriam, Bischoff, Stephan, Frei, Remo, Garn, Holger, Grimshaw, Kate, Hoffmann-Sommergruber, Karin, Lunjani, Nonhlanhla, Muraro, Antonella, Poulsen, Lars K., Renz, Harald, Sokolowska, Milena, Stanton, Catherine, and O'Mahony, Liam

Abstract

To fully understand the role of diet diversity on allergy outcomes and to set standards for conducting research in this field, the European Academy of Allergy and Clinical Immunology Task Force on Diet and Immunomodulation has systematically explored the association between diet diversity and allergy outcomes. In addition, a detailed narrative review of information on diet quality and diet patterns as they pertain to allergic outcomes is presented. Overall, we recommend that infants of any risk category for allergic disease should have a diverse diet, given no evidence of harm and some potential association of benefit in the prevention of particular allergic outcomes. In order to harmonize methods for future data collection and reporting, the task force members propose relevant definitions and important factors for consideration, when measuring diet diversity in the context of allergy. Consensus was achieved on practice points through the Delphi method. It is hoped that the definitions and considerations described herein will also enable better comparison of future studies and improve mechanistic studies and pathway analysis to understand how diet diversity modulates allergic outcomes.

Published
2020

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