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989 results on '"Vleggaar, Frank P."'

4. Type 1 Autoimmune Pancreatitis in Europe: Clinical Profile and Response to Treatment

Author

Drewes, A. Mohr, Haas, S.L., Hoyer, B.F., Hampe, J., Hinrichs, C. Noreen, Lerch, M.M., Aghdassi, A.A., Grote, T., Heuser, D.J., Ignatavicius, P., Malecka-Panas, E., Domínguez-Muñoz, J.E., López-Serrano, A., Auriemma, F., Oracz, G., Duman, D., Gubergrits, N., Overbeek, Kasper A., Poulsen, Jakob L., Lanzillotta, Marco, Vinge-Holmquist, Olof, Macinga, Peter, Demirci, A. Fatih, Sindhunata, Daniko P., Backhus, Johanna, Algül, Hana, Buijs, Jorie, Levy, Philippe, Kiriukova, Mariia, Goni, Elisabetta, Hollenbach, Marcus, Miksch, Rainer C., Kunovsky, Lumir, Vujasinovic, Miroslav, Nikolic, Sara, Dickerson, Luke, Hirth, Michael, Neurath, Markus F., Zumblick, Malte, Vila, Josephine, Jalal, Mustafa, Beyer, Georg, Frost, Fabian, Carrara, Silvia, Kala, Zdenek, Jabandziev, Petr, Sisman, Gurhan, Akyuz, Filiz, Capurso, Gabriele, Falconi, Massimo, Arlt, Alexander, Vleggaar, Frank P., Barresi, Luca, Greenhalf, Bill, Czakó, László, Hegyi, Peter, Hopper, Andrew, Nayar, Manu K., Gress, Thomas M., Vitali, Francesco, Schneider, Alexander, Halloran, Chris M., Trna, Jan, Okhlobystin, Alexey V., Dagna, Lorenzo, Cahen, Djuna L., Bordin, Dmitry, Rebours, Vinciane, Mayerle, Julia, Kahraman, Alisan, Rasch, Sebastian, Culver, Emma, Kleger, Alexander, Martínez-Moneo, Emma, Røkke, Ola, Hucl, Tomas, Olesen, Søren S., Bruno, Marco J., Della-Torre, Emanuel, Beuers, Ulrich, Löhr, J.-Matthias, and Rosendahl, Jonas

Published
2024
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5. Endoscopic ultrasonography-guided gastroenterostomy versus surgical gastrojejunostomy for palliation of malignant gastric outlet obstruction (ENDURO): study protocol for a randomized controlled trial

Author

Kastelijn, Janine B., van de Pavert, Yorick L., Besselink, Marc G., Fockens, Paul, Voermans, Rogier P., van Wanrooij, Roy L. J., de Wijkerslooth, Thomas R., Curvers, Wouter L., de Hingh, Ignace H. J. T., Bruno, Marco J., Koerkamp, Bas Groot, Patijn, Gijs A., Poen, Alexander C., van Hooft, Jeanin E., Inderson, Akin, Mieog, J. Sven D., Poley, Jan-Werner, Bijlsma, Alderina, Lips, Daan J., Venneman, Niels G., Verdonk, Robert C., van Dullemen, Hendrik M., Hoogwater, Frederik J. H., Frederix, Geert W. J., Molenaar, I. Quintus, Welsing, Paco M. J., Moons, Leon M. G., van Santvoort, Hjalmar C., and Vleggaar, Frank P.

Published
2023
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7. Intraductal Papillary Mucinous Neoplasms in High-Risk Individuals: Incidence, Growth Rate, and Malignancy Risk

Author

Overbeek, Kasper A., Koopmann, Brechtje D.M., Levink, Iris J.M., Tacelli, Matteo, Erler, Nicole S., Arcidiacono, Paolo Giorgio, Ausems, Margreet G.E., Wagner, Anja, van Eijck, Casper H., Groot Koerkamp, Bas, Busch, Olivier R., Besselink, Marc G., van der Vlugt, Manon, van Driel, Lydi M.J.W., Fockens, Paul, Vleggaar, Frank P., Poley, Jan-Werner, Capurso, Gabriele, Cahen, Djuna L., and Bruno, Marco J.

Published
2024
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10. Diagnostic accuracy of endoscopic ultrasonography-guided tissue acquisition prior to resection of pancreatic carcinoma: a nationwide analysis

Author

Quispel, Rutger, Schutz, Hannah M., Keultjes, Augustinus W.P., Erler, Nicole S., Janssen, Quisette P., van Hooft, Jeanin E., Venneman, Niels G., Honkoop, Pieter, Hol, Lieke, Scheffer, Robert C., Bisseling, Tanya M., Voermans, Rogier P., Vleggaar, Frank P., Schwartz, Matthijs P., Verdonk, Robert C., Hoge, Chantal V., Kuiken, Sjoerd D., Curvers, Wouter L., van Vilsteren, Frederike G.I., Poen, Alexander C., Spanier, Marcel B., Bruggink, Annette H., Smedts, Frank M., van Velthuysen, Marie-Louise F., van Eijck, Casper H., Besselink, Marc G., Veldt, Bart J., Koerkamp, Bas G., van Driel, Lydi M.J.W., and Bruno, Marco J.

Published
2023
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11. Gallstones as a cause in presumed acute alcoholic pancreatitis: observational multicentre study

Author

Sissingh, Noor J, primary, de Rijk, Fleur E M, additional, Timmerhuis, Hester C, additional, Umans, Devica S, additional, Anten, Marie-Paule G F, additional, Bouwense, Stefan A W, additional, van Delft, Foke, additional, van Eijck, Brechje C, additional, Erkelens, Willemien G, additional, Hazen, Wouter L, additional, Kuiken, Sjoerd D, additional, Quispel, Rutger, additional, Romkens, Tessa E H, additional, Schwartz, Matthijs P, additional, Seerden, Tom C, additional, Spanier, B W Marcel, additional, Verlaan, Tessa, additional, Vleggaar, Frank P, additional, Voermans, Rogier P, additional, Verdonk, Robert C, additional, and van Hooft, Jeanin E, additional

Published
2024
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12. Type 1 Autoimmune Pancreatitis in Europe: Clinical Profile and Response to Treatment

Author

Overbeek, Kasper A., primary, Poulsen, Jakob L., additional, Lanzillotta, Marco, additional, Vinge-Holmquist, Olof, additional, Macinga, Peter, additional, Demirci, A. Fatih, additional, Sindhunata, Daniko P., additional, Backhus, Johanna, additional, Algül, Hana, additional, Buijs, Jorie, additional, Levy, Philippe, additional, Kiriukova, Mariia, additional, Goni, Elisabetta, additional, Hollenbach, Marcus, additional, Miksch, Rainer C., additional, Kunovsky, Lumir, additional, Vujasinovic, Miroslav, additional, Nikolic, Sara, additional, Dickerson, Luke, additional, Hirth, Michael, additional, Neurath, Markus F., additional, Zumblick, Malte, additional, Vila, Josephine, additional, Jalal, Mustafa, additional, Beyer, Georg, additional, Frost, Fabian, additional, Carrara, Silvia, additional, Kala, Zdenek, additional, Jabandziev, Petr, additional, Sisman, Gurhan, additional, Akyuz, Filiz, additional, Capurso, Gabriele, additional, Falconi, Massimo, additional, Arlt, Alexander, additional, Vleggaar, Frank P., additional, Barresi, Luca, additional, Greenhalf, Bill, additional, Czakó, László, additional, Hegyi, Peter, additional, Hopper, Andrew, additional, Nayar, Manu K., additional, Gress, Thomas M., additional, Vitali, Francesco, additional, Schneider, Alexander, additional, Halloran, Chris M., additional, Trna, Jan, additional, Okhlobystin, Alexey V., additional, Dagna, Lorenzo, additional, Cahen, Djuna L., additional, Bordin, Dmitry, additional, Rebours, Vinciane, additional, Mayerle, Julia, additional, Kahraman, Alisan, additional, Rasch, Sebastian, additional, Culver, Emma, additional, Kleger, Alexander, additional, Martínez-Moneo, Emma, additional, Røkke, Ola, additional, Hucl, Tomas, additional, Olesen, Søren S., additional, Bruno, Marco J., additional, Della-Torre, Emanuel, additional, Beuers, Ulrich, additional, Löhr, J.-Matthias, additional, Rosendahl, Jonas, additional, Drewes, A. Mohr, additional, Haas, S.L., additional, Hoyer, B.F., additional, Hampe, J., additional, Hinrichs, C. Noreen, additional, Lerch, M.M., additional, Aghdassi, A.A., additional, Grote, T., additional, Heuser, D.J., additional, Ignatavicius, P., additional, Malecka-Panas, E., additional, Domínguez-Muñoz, J.E., additional, López-Serrano, A., additional, Auriemma, F., additional, Oracz, G., additional, Duman, D., additional, and Gubergrits, N., additional

Published
2024
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15. Intraductal papillary mucinous neoplasms in high-risk individuals:incidence, growth rate, and malignancy risk

Author

Overbeek, Kasper A, Koopmann, Brechtje D M, Levink, Iris J M, Tacelli, Matteo, Erler, Nicole S, Arcidiacono, Paolo Giorgio, Ausems, Margreet G E, Wagner, Anja, van Eijck, Casper H, Koerkamp, Bas Groot, Busch, Olivier R, Besselink, Marc G, van der Vlugt, Manon, van Driel, Lydi M J W, Fockens, Paul, Vleggaar, Frank P, Poley, Jan-Werner, Capurso, Gabriele, Cahen, Djuna L, Bruno, Marco J, Overbeek, Kasper A, Koopmann, Brechtje D M, Levink, Iris J M, Tacelli, Matteo, Erler, Nicole S, Arcidiacono, Paolo Giorgio, Ausems, Margreet G E, Wagner, Anja, van Eijck, Casper H, Koerkamp, Bas Groot, Busch, Olivier R, Besselink, Marc G, van der Vlugt, Manon, van Driel, Lydi M J W, Fockens, Paul, Vleggaar, Frank P, Poley, Jan-Werner, Capurso, Gabriele, Cahen, Djuna L, and Bruno, Marco J

Abstract

BACKGROUND AND AIMS: In high-risk individuals (HRIs), we aimed to assess the cumulative incidence of intraductal papillary mucinous neoplasms (IPMNs) and compare IPMN growth, neoplastic progression rate, and the value of growth as predictor for neoplastic progression to these in sporadic IPMNs.METHODS: We performed annual surveillance of Dutch HRIs, involving carriers of germline pathogenic variants (PV) and PV-negative familial pancreatic cancer (FPC) kindreds. HRIs with IPMNs were compared to Italian individuals without familial risk under surveillance for sporadic IPMNs.RESULTS: 457 HRIs were followed for 48 months (range 2-172); the estimated cumulative IPMN incidence was 46% (95%CI 28-64). In comparison to 442 controls, IPMNs in HRIs were more likely to grow ≥ 2.5 mm/year (31% versus 7%, P<0.001) and to develop worrisome features (32% versus 19%, P=0.010). PV carriers with IPMNs more often displayed neoplastic progression (n=3, 11%; versus n=6, 1%; P=0.011), while FPC kindreds did not (n=0, 0%; P=1.000). The malignancy risk in a PV carrier with an IPMN was 23% for growth rates ≥2.5 mm/year (n=13), 30% for ≥5 mm/year (n=10), and 60% for ≥10 mm/year (n=5).CONCLUSIONS: The cumulative incidence of IPMNs in HRIs is higher than previously reported in the general population. Compared to sporadic IPMNs, they have an increased growth rate. PV carriers with IPMNs are suggested to be at a higher malignancy risk. Intensive follow-up should be considered for PV carriers with an IPMN growing ≥2.5 mm/year, and surgical resection for those growing ≥5 mm/year.

Published
2024

16. Intraductal papillary mucinous neoplasms in high-risk individuals: incidence, growth rate, and malignancy risk

Author

Cancer, Genetica Klinische Genetica, MS MDL 1, Overbeek, Kasper A, Koopmann, Brechtje D M, Levink, Iris J M, Tacelli, Matteo, Erler, Nicole S, Arcidiacono, Paolo Giorgio, Ausems, Margreet G E, Wagner, Anja, van Eijck, Casper H, Koerkamp, Bas Groot, Busch, Olivier R, Besselink, Marc G, van der Vlugt, Manon, van Driel, Lydi M J W, Fockens, Paul, Vleggaar, Frank P, Poley, Jan-Werner, Capurso, Gabriele, Cahen, Djuna L, Bruno, Marco J, Dutch Familial Pancreatic Cancer Surveillance Study work group, Cancer, Genetica Klinische Genetica, MS MDL 1, Overbeek, Kasper A, Koopmann, Brechtje D M, Levink, Iris J M, Tacelli, Matteo, Erler, Nicole S, Arcidiacono, Paolo Giorgio, Ausems, Margreet G E, Wagner, Anja, van Eijck, Casper H, Koerkamp, Bas Groot, Busch, Olivier R, Besselink, Marc G, van der Vlugt, Manon, van Driel, Lydi M J W, Fockens, Paul, Vleggaar, Frank P, Poley, Jan-Werner, Capurso, Gabriele, Cahen, Djuna L, Bruno, Marco J, and Dutch Familial Pancreatic Cancer Surveillance Study work group

Published
2024

17. Type 1 Autoimmune Pancreatitis in Europe:Clinical Profile and Response to Treatment

Author

Overbeek, Kasper A., Poulsen, Jakob L., Lanzillotta, Marco, Vinge-Holmquist, Olof, Macinga, Peter, Demirci, A. Fatih, Sindhunata, Daniko P., Backhus, Johanna, Algül, Hana, Buijs, Jorie, Levy, Philippe, Kiriukova, Mariia, Goni, Elisabetta, Hollenbach, Marcus, Miksch, Rainer C., Kunovsky, Lumir, Vujasinovic, Miroslav, Nikolic, Sara, Dickerson, Luke, Hirth, Michael, Neurath, Markus F., Zumblick, Malte, Vila, Josephine, Jalal, Mustafa, Beyer, Georg, Frost, Fabian, Carrara, Silvia, Kala, Zdenek, Jabandziev, Petr, Sisman, Gurhan, Akyuz, Filiz, Capurso, Gabriele, Falconi, Massimo, Arlt, Alexander, Vleggaar, Frank P., Barresi, Luca, Greenhalf, Bill, Czakó, László, Hegyi, Peter, Hopper, Andrew, Nayar, Manu K., Gress, Thomas M., Vitali, Francesco, Schneider, Alexander, Halloran, Chris M., Trna, Jan, Okhlobystin, Alexey V., Cahen, Djuna L., Bruno, Marco J., Haas, S. L., Overbeek, Kasper A., Poulsen, Jakob L., Lanzillotta, Marco, Vinge-Holmquist, Olof, Macinga, Peter, Demirci, A. Fatih, Sindhunata, Daniko P., Backhus, Johanna, Algül, Hana, Buijs, Jorie, Levy, Philippe, Kiriukova, Mariia, Goni, Elisabetta, Hollenbach, Marcus, Miksch, Rainer C., Kunovsky, Lumir, Vujasinovic, Miroslav, Nikolic, Sara, Dickerson, Luke, Hirth, Michael, Neurath, Markus F., Zumblick, Malte, Vila, Josephine, Jalal, Mustafa, Beyer, Georg, Frost, Fabian, Carrara, Silvia, Kala, Zdenek, Jabandziev, Petr, Sisman, Gurhan, Akyuz, Filiz, Capurso, Gabriele, Falconi, Massimo, Arlt, Alexander, Vleggaar, Frank P., Barresi, Luca, Greenhalf, Bill, Czakó, László, Hegyi, Peter, Hopper, Andrew, Nayar, Manu K., Gress, Thomas M., Vitali, Francesco, Schneider, Alexander, Halloran, Chris M., Trna, Jan, Okhlobystin, Alexey V., Cahen, Djuna L., Bruno, Marco J., and Haas, S. L.

Abstract

Background & Aims: Autoimmune pancreatitis (AIP) is an immune-mediated disease of the pancreas with distinct pathophysiology and manifestations. Our aims were to characterize type 1 AIP in a large pan-European cohort and study the effectiveness of current treatment regimens. Methods: We retrospectively analyzed adults diagnosed since 2005 with type 1 or not-otherwise-specified AIP in 42 European university hospitals. Type 1 AIP was uniformly diagnosed using specific diagnostic criteria. Patients with type 2 AIP and those who had undergone pancreatic surgery were excluded. The primary end point was complete remission, defined as the absence of clinical symptoms and resolution of the index radiologic pancreatic abnormalities attributed to AIP. Results: We included 735 individuals with AIP (69% male; median age, 57 years; 85% White). Steroid treatment was started in 634 patients, of whom 9 (1%) were lost to follow-up. The remaining 625 had a 79% (496/625) complete, 18% (111/625) partial, and 97% (607/625) cumulative remission rate, whereas 3% (18/625) did not achieve remission. No treatment was given in 95 patients, who had a 61% complete (58/95), 19% partial (18/95), and 80% cumulative (76/95) spontaneous remission rate. Higher (≥0.4 mg/kg/day) corticosteroid doses were no more effective than lower (<0.4 mg/kg/day) doses (odds ratio, 0.428; 95% confidence interval, 0.054–3.387) and neither was a starting dose duration >2 weeks (odds ratio, 0.908; 95% confidence interval, 0.818–1.009). Elevated IgG4 levels were independently associated with a decreased chance of complete remission (odds ratio, 0.639; 95% confidence interval, 0.427–0.955). Relapse occurred in 30% of patients. Relapses within 6 months of remission induction were independent of the steroid-tapering duration, induction treatment duration, and total cumulative dose. Conclusions: Patients with type 1 AIP and elevated IgG4 level may need closer monitoring. For remission induction, a starting dose

Published
2024

18. Timeline of Development of Pancreatic Cancer and Implications for Successful Early Detection in High-Risk Individuals

Author

Overbeek, Kasper A., Goggins, Michael G., Dbouk, Mohamad, Levink, Iris J.M., Koopmann, Brechtje D.M., Chuidian, Miguel, Konings, Ingrid C.A.W., Paiella, Salvatore, Earl, Julie, Fockens, Paul, Gress, Thomas M., Ausems, Margreet G.E.M., Poley, Jan-Werner, Thosani, Nirav C., Half, Elizabeth, Lachter, Jesse, Stoffel, Elena M., Kwon, Richard S., Stoita, Alina, Kastrinos, Fay, Lucas, Aimee L., Syngal, Sapna, Brand, Randall E., Chak, Amitabh, Carrato, Alfredo, Vleggaar, Frank P., Bartsch, Detlef K., van Hooft, Jeanin E., Cahen, Djuna L., Canto, Marcia Irene, and Bruno, Marco J.

Published
2022
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19. Oncological outcomes of screen-detected and non-screen-detected T1 colorectal cancers

Author

van der Schee, Lisa, additional, Haasnoot, Krijn Jan Cornelis, additional, Elias, Sjoerd G., additional, Gijsbers, Kim, additional, Alderlieste, Y.A., additional, Backes, Yara, additional, van Berkel, Annemarie M., additional, Boersma, Femke, additional, ter Borg, F, additional, Breekveldt, Emilie C.H., additional, Kessels, Koen, additional, Koopman, Miriam, additional, Lansdorp-Vogelaar, Iris, additional, van Leerdam, Monique E, additional, Rasschaert, Gertjan, additional, Schreuder, Ramon Michel, additional, Schrauwen, R W.M., additional, Seerden, Tom C.J., additional, Spanier, Marcel B.W., additional, Terhaar sive Droste, Jochim S., additional, Toes-Zoutendijk, Esther, additional, Tuynman, Jurriaan, additional, Vink, Geraldine R., additional, de Vos tot Nederveen Cappel, Wouter H, additional, Vleggaar, Frank P., additional, Lacle, M.M, additional, and Moons, Leon MG, additional

Published
2024
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21. The safety and efficacy of a new 20-mm lumen apposing metal stent (lams) for the endoscopic treatment of pancreatic and peripancreatic fluid collections: a large international, multicenter study

Author

Anderloni, Andrea, Fabbri, Carlo, Nieto, Jose, Uwe, Will, Dollhopf, Markus, Aparicio, José Ramón, Perez-Miranda, Manuel, Tarantino, Ilaria, Arlt, Alexander, Vleggaar, Frank, Vanbiervliet, Geoffrey, Hampe, Jochen, Kahaleh, Michel, Vila, Juan J., Dayyeh, Barham K. Abu, Storm, Andrew C., Fugazza, Alessandro, Binda, Cecilia, Charachon, Antoine, Sevilla-Ribota, Sergio, Tyberg, Amy, Robert, Moran, Wani, Sachin, Repici, Alessandro, Sethi, Amrita, Khashab, Mouen A., and Kunda, Rastislav

Published
2021
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22. Colonoscopic-Assisted Laparoscopic Wedge Resection for Colonic Lesions: A Prospective Multicentre Cohort Study (LIMERIC-Study)

Author

Leicher, Laura W., Huisman, Jelle F., van Grevenstein, Wilhelmina M. U., Didden, Paul, Backes, Yara, Offerhaus, G. Johan A., Laclé, Miangela M., Moll, Freek C. P., Geesing, Joost M. J., Smakman, Niels, Droste, Jochim S. Terhaar Sive, Verdaasdonk, Emiel G. G., ter Borg, Frank, Talsma, A. Koen, Erkelens, G. Willemien, van der Zaag, Edwin S., Schrauwen, Ruud W. M., van Wely, Bob J., Schot, Ingrid, Vermaas, Maarten, van Bergeijk, Jeroen D., Sietses, Colin, Hazen, Wouter L., Wasowicz, Dareczka K., Ramsoekh, Dewkoemar, Tuynman, Jurriaan B., Alderlieste, Yasser A., Renger, Rutger-Jan, Oort, Frank A., Bilgen, Ernst Jan Spillenaar, Vleggaar, Frank P., Vasen, Hans F. A., Cappel, Wouter H. de Vos tot Nederveen, Moons, Leon M. G., and van Westreenen, Henderik L.

Published
2022
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23. Associations of non-pedunculated T1 colorectal adenocarcinoma outcome with consensus molecular subtypes, immunoscore, and microsatellite status: a multicenter case-cohort study

Author

Haasnoot, Krijn J.C., Backes, Yara, Moons, Leon M.G., Kranenburg, Onno, Trinh, Anne, Vermeulen, Louis, Noë, Michaël, Tuynman, Jurriaan B., van Lent, Anja U.G., van Ginneken, Rosaline, Seldenrijk, Cornelis A., Raicu, Mihaela G., Trumpi, Kari, Ubink, Inge, Milne, Anya N., Boonstra, Jurjen J., Groen, John N., Schwartz, Matthijs P., Wolfhagen, Frank H.J., Geesing, Joost M.J., ter Borg, Frank, Brosens, Lodewijk A.A., van Bergeijk, Jeroen, Spanier, Bernhard W.M., de Vos tot Nederveen Cappel, Wouter H., Kessels, Koen, Seerden, Tom C.J., Vleggaar, Frank P., Offerhaus, G. Johan A., Siersema, Peter D., Elias, Sjoerd G., and Laclé, Miangela M.

Published
2020
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24. Forskolin-induced swelling of intestinal organoids correlates with disease severity in adults with cystic fibrosis and homozygous F508del mutations

Author

de Winter – de Groot, Karin M., Berkers, Gitte, Marck – van der Wilt, Rozemarijn E.P., van der Meer, Renske, Vonk, Annelotte, Dekkers, Johanna F., Geerdink, Margot, Michel, Sabine, Kruisselbrink, Evelien, Vries, Rob, Clevers, Hans, Vleggaar, Frank P., Elias, Sjoerd G., Heijerman, Harry G.M., van der Ent, Cornelis K., and Beekman, Jeffrey M.

Published
2020
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25. International multicenter comprehensive analysis of adverse events associated with lumen-apposing metal stent placement for pancreatic fluid collection drainage

Author

Fugazza, Alessandro, Sethi, Amrita, Trindade, Arvind J., Troncone, Edoardo, Devlin, John, Khashab, Mouen A., Vleggaar, Frank P., Bogte, Auke, Tarantino, Ilaria, Deprez, Pierre H., Fabbri, Carlo, Aparicio, José Ramón, Fockens, Paul, Voermans, Rogier P., Uwe, Will, Vanbiervliet, Geoffroy, Charachon, Antoine, Packey, Christopher D., Benias, Petros C., El-Sherif, Yasser, Paiji, Christopher, Ligresti, Dario, Binda, Cecilia, Martínez, Belén, Correale, Loredana, Adler, Douglas G., Repici, Alessandro, and Anderloni, Andrea

Published
2020
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28. Pedunculated Morphology of T1 Colorectal Tumors Associates With Reduced Risk of Adverse Outcome

Author

Kessels, Koen, Backes, Yara, Elias, Sjoerd G., van den Blink, Aneya, Offerhaus, G. Johan A., van Bergeijk, Jeroen D., Groen, John N., Seerden, Tom C.J., Schwartz, Matthijs P., de Vos tot Nederveen Cappel, Wouter H., Spanier, Bernhard W.M., Geesing, Joost M.J., Kerkhof, Marjon, Siersema, Peter D., Didden, Paul, Boonstra, Jurjen J., Herrero, Lorenza Alvarez, Wolfhagen, Frank H.J., ter Borg, Frank, van Lent, Anja U., Terhaar sive Droste, Jochim S., Hazen, Wouter L., Schrauwen, Ruud W.M., Vleggaar, Frank P., Laclé, Miangela M., and Moons, Leon M.G.

Published
2019
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29. Histologic Factors Associated With Need for Surgery in Patients With Pedunculated T1 Colorectal Carcinomas

Author

Backes, Yara, Elias, Sjoerd G., Groen, John N., Schwartz, Matthijs P., Wolfhagen, Frank H.J., Geesing, Joost M.J., ter Borg, Frank, van Bergeijk, Jeroen, Spanier, Bernhard W.M., de Vos tot Nederveen Cappel, Wouter H., Kessels, Koen, Seldenrijk, Cornelis A., Raicu, Mihaela G., Drillenburg, Paul, Milne, Anya N., Kerkhof, Marjon, Seerden, Tom C.J., Siersema, Peter D., Vleggaar, Frank P., Offerhaus, G. Johan A., Lacle, Miangela M., and Moons, Leon M.G.

Published
2018
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30. Endoscopic or surgical step-up approach for infected necrotising pancreatitis: a multicentre randomised trial

Author

Manusama, Eric R, Hadithi, Mohammed, Rosman, Camiel, Schaapherder, Alexander F, Schoon, Erik J, van Brunschot, Sandra, van Grinsven, Janneke, van Santvoort, Hjalmar C, Bakker, Olaf J, Besselink, Marc G, Boermeester, Marja A, Bollen, Thomas L, Bosscha, Koop, Bouwense, Stefan A, Bruno, Marco J, Cappendijk, Vincent C, Consten, Esther C, Dejong, Cornelis H, van Eijck, Casper H, Erkelens, Willemien G, van Goor, Harry, van Grevenstein, Wilhelmina M U, Haveman, Jan-Willem, Hofker, Sijbrand H, Jansen, Jeroen M, Laméris, Johan S, van Lienden, Krijn P, Meijssen, Maarten A, Mulder, Chris J, Nieuwenhuijs, Vincent B, Poley, Jan-Werner, Quispel, Rutger, de Ridder, Rogier J, Römkens, Tessa E, Scheepers, Joris J, Schepers, Nicolien J, Schwartz, Matthijs P, Seerden, Tom, Spanier, B W Marcel, Straathof, Jan Willem A, Strijker, Marin, Timmer, Robin, Venneman, Niels G, Vleggaar, Frank P, Voermans, Rogier P, Witteman, Ben J, Gooszen, Hein G, Dijkgraaf, Marcel G, and Fockens, Paul

Published
2018
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33. Relevance of polyp size for primary endoscopic full-thickness resection of suspected T1 colorectal cancers

Author

Didden, Paul, Van Eijck Van Heslinga, Rixta A.H., Schwartz, Matthijs P., Arensman, L. R., Vleggaar, Frank P., De Graaf, Wilmar, Koch, Arjun D., Doukas, Michael, Lacle, Miangela M., Moons, Leon M.G., Gastroenterology & Hepatology, and Pathology

Subjects
Treatment Outcome, Endoscopic Mucosal Resection, SDG 3 - Good Health and Well-being, Gastroenterology, Humans, Colorectal Neoplasms, Retrospective Studies
Abstract

Background En bloc local excision of suspected T1 colorectal cancer (CRC) provides optimal tumor risk assessment with curative intent. Endoscopic full-thickness resection (eFTR) with an over-the-scope device has emerged as a local excision technique for T1 CRCs, but data on the upper size limit for achieving a histological complete (R0) resection are lacking. We aimed to determine the influence of polyp size on the R0 rate. Methods eFTR procedures for suspected T1 CRCs performed between 2015 and 2021 were selected from the endoscopy databases of three tertiary centers. The main outcome was R0 resection, defined as tumor- and dysplasia-free margins (≥ 0.1 mm) for both the deep and lateral resection margins. Regression analysis was performed to identify risk factors for R1/Rx resection, mainly focusing on endoscopically estimated polyp size. Results 136 patients underwent eFTR for suspected T1 CRC (median size 15 mm [IQR 13–18 mm]; 83.1 % cancer). The rates of technical success and R0 resection were 87.5 % (119/136; 95 %CI 80.9 %–92.1 %) and 79.7 % (106/136; 95 %CI 72.1 %–85.7 %), respectively. Increasing polyp size was significantly associated with R1/Rx resection (risk ratio 2.35 per 5-mm increase, 95 %CI 1.80–3.07; P 20 mm. Conclusions eFTR is associated with a 90 % R0 rate for T1 CRCs of ≤ 15 mm. Performing eFTR for polyps 16–20 mm should depend on access, their mobility, and the availability of alternative resection techniques. eFTR for > 20-mm polyps results in a high R1 rate and should not be recommended.

Published
2022

34. Endoscopic ultrasonography-guided gastroenterostomy versus surgical gastrojejunostomy for palliation of malignant gastric outlet obstruction (ENDURO): study protocol for a randomised controlled trial

Author

de Pavert, Yorick L. van, primary, Kastelijn, Janine B., additional, Besselink, Marc G., additional, Fockens, Paul, additional, Voermans, Rogier P., additional, Wanrooij, Roy L.J. van, additional, de Wijkerslooth, Thomas R., additional, Curvers, Wouter L., additional, de Hingh, Ignace H.J.T., additional, Bruno, Marco J., additional, Koerkamp, Bas Groot, additional, Patijn, Gijs A., additional, Poen, Alexander C., additional, Hooft, Jeanin E. van, additional, Inderson, Akin, additional, Mieog, J. Sven D., additional, Poley, Jan-Werner, additional, Bijlsma, Alderina, additional, Lips, Daan J., additional, Venneman, Niels G., additional, Verdonk, Robert C., additional, Dullemen, Hendrik M. van, additional, Hoogwater, Frederik J.H., additional, Frederix, Geert W.J., additional, Molenaar, I. Quintus, additional, Welsing, Paco M.J., additional, Moons, Leon M.G., additional, Santvoort, Hjalmar C. van, additional, and Vleggaar, Frank P., additional

Published
2023
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36. Intraductal Papillary Mucinous Neoplasms in High-Risk Individuals: Incidence, Growth Rate, and Malignancy Risk

Author

Overbeek, Kasper A., primary, Koopmann, Brechtje D.M., additional, Levink, Iris J.M., additional, Tacelli, Matteo, additional, Erler, Nicole S., additional, Arcidiacono, Paolo Giorgio, additional, Ausems, Margreet G.E., additional, Wagner, Anja, additional, van Eijck, Casper H., additional, Groot Koerkamp, Bas, additional, Busch, Olivier R., additional, Besselink, Marc G., additional, van der Vlugt, Manon, additional, van Driel, Lydi M.J.W., additional, Fockens, Paul, additional, Vleggaar, Frank P., additional, Poley, Jan-Werner, additional, Capurso, Gabriele, additional, Cahen, Djuna L., additional, and Bruno, Marco J., additional

Published
2023
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37. Long-term follow-up study of necrotising pancreatitis: interventions, complications and quality of life

Author

Hollemans, Robbert A, Timmerhuis, Hester C, Besselink, Marc G, Bouwense, Stefan A W, Bruno, Marco, van Duijvendijk, Peter, van Geenen, Erwin-Jan, Hadithi, Muhammed, Hofker, Sybrand, Van-Hooft, Jeanin E, Kager, Liesbeth M, Manusama, Eric R, Poley, Jan-Werner, Quispel, Rutger, Ro¨mkens, Tessa, van der Schelling, George P, Schwartz, Matthijs P, Spanier, Bernhard W M, Stommel, Martijn, Tan, Adriaan, Venneman, Niels G, Vleggaar, Frank, van Wanrooij, Roy L J, Bollen, Thomas L, Voermans, Rogier P, Verdonk, Robert C, and van Santvoort, Hjalmar C

Abstract

ObjectiveTo describe the long-term consequences of necrotising pancreatitis, including complications, the need for interventions and the quality of life.DesignLong-term follow-up of a prospective multicentre cohort of 373 necrotising pancreatitis patients (2005–2008) was performed. Patients were prospectively evaluated and received questionnaires. Readmissions (ie, for recurrent or chronic pancreatitis), interventions, pancreatic insufficiency and quality of life were compared between initial treatment groups: conservative, endoscopic/percutaneous drainage alone and necrosectomy. Associations of patient and disease characteristics during index admission with outcomes during follow-up were assessed.ResultsDuring a median follow-up of 13.5 years (range 12–15.5 years), 97/373 patients (26%) were readmitted for recurrent pancreatitis. Endoscopic or percutaneous drainage was performed in 47/373 patients (13%), of whom 21/47 patients (45%) were initially treated conservatively. Pancreatic necrosectomy or pancreatic surgery was performed in 31/373 patients (8%), without differences between treatment groups. Endocrine insufficiency (126/373 patients; 34%) and exocrine insufficiency (90/373 patients; 38%), developed less often following conservative treatment (p<0.001 and p=0.016, respectively). Quality of life scores did not differ between groups. Pancreatic gland necrosis >50% during initial admission was associated with percutaneous/endoscopic drainage (OR 4.3 (95% CI 1.5 to 12.2)), pancreatic surgery (OR 3.2 (95% CI 1.1 to 9.5) and development of endocrine insufficiency (OR13.1 (95% CI 5.3 to 32.0) and exocrine insufficiency (OR6.1 (95% CI 2.4 to 15.5) during follow-up.ConclusionAcute necrotising pancreatitis carries a substantial disease burden during long-term follow-up in terms of recurrent disease, the necessity for interventions and development of pancreatic insufficiency, even when treated conservatively during the index admission. Extensive (>50%) pancreatic parenchymal necrosis seems to be an important predictor of interventions and complications during follow-up.

Published
2024
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38. Standardised training for endoscopic mucosal resection of large non-pedunculated colorectal polyps to reduce recurrence (*STAR-LNPCP study): a multicentre cluster randomised trial

Author

Meulen, Lonne W T, Bogie, Roel M M, Siersema, Peter D, Winkens, Bjorn, Vlug, Marije S, Wolfhagen, Frank H J, Baven-Pronk, Martine, van der Voorn, Michael, Schwartz, Matthijs P, Vogelaar, Lauran, de Vos tot Nederveen Cappel, Wouter H, Seerden, Tom C J, Hazen, Wouter L, Schrauwen, Ruud W M, Alvarez Herrero, Lorenza, Schreuder, Ramon-Michel M, van Nunen, Annick B, Stoop, Esther, de Bruin, Gijs J, Bos, Philip, Marsman, Willem A, Kuiper, Edith, de Bièvre, Marc, Alderlieste, Yasser A, Roomer, Robert, Groen, John, Bargeman, Marloes, van Leerdam, Monique E, Roberts-Bos, Linda, Boersma, Femke, Thurnau, Karsten, de Vries, Roland S, Ramaker, Jos M, Vleggaar, Frank P, de Ridder, Rogier J, Pellisé, María, Bourke, Michael J, Masclee, Ad A M, and Moons, Leon M G

Abstract

ObjectiveEndoscopic mucosal resection (EMR) is the preferred treatment for non-invasive large (≥20 mm) non-pedunculated colorectal polyps (LNPCPs) but is associated with an early recurrence rate of up to 30%. We evaluated whether standardised EMR training could reduce recurrence rates in Dutch community hospitals.DesignIn this multicentre cluster randomised trial, 59 endoscopists from 30 hospitals were randomly assigned to the intervention group (e-learning and 2-day training including hands-on session) or control group. From April 2019 to August 2021, all consecutive EMR-treated LNPCPs were included. Primary endpoint was recurrence rate after 6 months.ResultsA total of 1412 LNPCPs were included; 699 in the intervention group and 713 in the control group (median size 30 mm vs 30 mm, 45% vs 52% size, morphology, site and access (SMSA) score IV, 64% vs 64% proximal location). Recurrence rates were lower in the intervention group compared with controls (13% vs 25%, OR 0.43; 95% CI 0.23 to 0.78; p=0.005) with similar complication rates (8% vs 9%, OR 0.93; 95% CI 0.64 to 1.36; p=0.720). Recurrences were more often unifocal in the intervention group (92% vs 76%; p=0.006). In sensitivity analysis, the benefit of the intervention on recurrence rate was only observed in the 20–40 mm LNPCPs (5% vs 20% in 20–29 mm, p=0.001; 10% vs 21% in 30–39 mm, p=0.013) but less evident in ≥40 mm LNPCPs (24% vs 31%; p=0.151). In a post hoc analysis, the training effect was maintained in the study group, while in the control group the recurrence rate remained high.ConclusionA compact standardised EMR training for LNPCPs significantly reduced recurrences in community hospitals. This strongly argues for a national dedicated training programme for endoscopists performing EMR of ≥20 mm LNPCPs. Interestingly, in sensitivity analysis, this benefit was limited for LNPCPs ≥40 mm.Trial registration numberNTR7477.

Published
2024
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39. Short-term and Long-term Outcomes of a Disruption and Disconnection of the Pancreatic Duct in Necrotizing Pancreatitis: A Multicenter Cohort Study in 896 Patients

Author

Timmerhuis, Hester C, van Dijk, Sven M, Hollemans, Robbert A, Sperna Weiland, Christina J, Umans, Devica S, Boxhoorn, Lotte, Hallensleben, Nora H, van der Sluijs, Rogier, Brouwer, Lieke, van Duijvendijk, Peter, Kager, Liesbeth, Kuiken, Sjoerd, Poley, Jan-Werner, de Ridder, Rogier, Römkens, Tessa, Quispel, Rutger, Schwartz, Matthijs P, Tan, Adriaan C I T L, Venneman, Niels G, Vleggaar, Frank P, van Wanrooij, Roy L J, Witteman, Ben J, van Geenen, Erwin, Molenaar, I Quintus, Bruno, Marco J, van Hooft, Jeanin E, Besselink, Marc G, Voermans, Rogier P, Bollen, Thomas L, Verdonk, Robert C, van Santvoort, Hjalmar C, Dutch Pancreatitis Study Group, Timmerhuis, Hester C, van Dijk, Sven M, Hollemans, Robbert A, Sperna Weiland, Christina J, Umans, Devica S, Boxhoorn, Lotte, Hallensleben, Nora H, van der Sluijs, Rogier, Brouwer, Lieke, van Duijvendijk, Peter, Kager, Liesbeth, Kuiken, Sjoerd, Poley, Jan-Werner, de Ridder, Rogier, Römkens, Tessa, Quispel, Rutger, Schwartz, Matthijs P, Tan, Adriaan C I T L, Venneman, Niels G, Vleggaar, Frank P, van Wanrooij, Roy L J, Witteman, Ben J, van Geenen, Erwin, Molenaar, I Quintus, Bruno, Marco J, van Hooft, Jeanin E, Besselink, Marc G, Voermans, Rogier P, Bollen, Thomas L, Verdonk, Robert C, van Santvoort, Hjalmar C, and Dutch Pancreatitis Study Group

Abstract

INTRODUCTION:Necrotizing pancreatitis may result in a disrupted or disconnected pancreatic duct (DPD) with the potential for long-lasting negative impact on a patient's clinical outcome. There is a lack of detailed data on the full clinical spectrum of DPD, which is critical for the development of better diagnostic and treatment strategies.METHODS:We performed a long-term post hoc analysis of a prospectively collected nationwide cohort of 896 patients with necrotizing pancreatitis (2005-2015). The median follow-up after hospital admission was 75 months (P25-P75: 41-151). Clinical outcomes of patients with and without DPD were compared using regression analyses, adjusted for potential confounders. Predictive features for DPD were explored.RESULTS:DPD was confirmed in 243 (27%) of the 896 patients and resulted in worse clinical outcomes during both the patient's initial admission and follow-up. During hospital admission, DPD was associated with an increased rate of new-onset intensive care unit admission (adjusted odds ratio [aOR] 2.52; 95% confidence interval [CI] 1.62-3.93), new-onset organ failure (aOR 2.26; 95% CI 1.45-3.55), infected necrosis (aOR 4.63; 95% CI 2.87-7.64), and pancreatic interventions (aOR 7.55; 95% CI 4.23-13.96). During long-term follow-up, DPD increased the risk of pancreatic intervention (aOR 9.71; 95% CI 5.37-18.30), recurrent pancreatitis (aOR 2.08; 95% CI 1.32-3.29), chronic pancreatitis (aOR 2.73; 95% CI 1.47-5.15), and endocrine pancreatic insufficiency (aOR 1.63; 95% CI 1.05-2.53). Central or subtotal pancreatic necrosis on computed tomography (OR 9.49; 95% CI 6.31-14.29) and a high level of serum C-reactive protein in the first 48 hours after admission (per 10-point increase, OR 1.02; 95% CI 1.00-1.03) were identified as independent predictors for developing DPD.DISCUSSION:At least 1 of every 4 patients with necrotizing pancreatitis experience DPD, which is associated with detrimental, short-term and long-term interventions, and comp

Published
2023

40. Diagnostic accuracy of endoscopic ultrasonography-guided tissue acquisition prior to resection of pancreatic carcinoma:a nationwide analysis

Author

Quispel, Rutger, Schutz, Hannah M., Keultjes, Augustinus W.P., Erler, Nicole S., Janssen, Quisette P., van Hooft, Jeanin E., Venneman, Niels G., Honkoop, Pieter, Hol, Lieke, Scheffer, Robert C., Bisseling, Tanya M., Voermans, Rogier P., Vleggaar, Frank P., Schwartz, Matthijs P., Verdonk, Robert C., Hoge, Chantal V., Kuiken, Sjoerd D., Curvers, Wouter L., van Vilsteren, Frederike G.I., Poen, Alexander C., Spanier, Marcel B., Bruggink, Annette H., Smedts, Frank M., van Velthuysen, Marie Louise F., van Eijck, Casper H., Besselink, Marc G., Veldt, Bart J., Koerkamp, Bas G., van Driel, Lydi M.J.W., Bruno, Marco J., Quispel, Rutger, Schutz, Hannah M., Keultjes, Augustinus W.P., Erler, Nicole S., Janssen, Quisette P., van Hooft, Jeanin E., Venneman, Niels G., Honkoop, Pieter, Hol, Lieke, Scheffer, Robert C., Bisseling, Tanya M., Voermans, Rogier P., Vleggaar, Frank P., Schwartz, Matthijs P., Verdonk, Robert C., Hoge, Chantal V., Kuiken, Sjoerd D., Curvers, Wouter L., van Vilsteren, Frederike G.I., Poen, Alexander C., Spanier, Marcel B., Bruggink, Annette H., Smedts, Frank M., van Velthuysen, Marie Louise F., van Eijck, Casper H., Besselink, Marc G., Veldt, Bart J., Koerkamp, Bas G., van Driel, Lydi M.J.W., and Bruno, Marco J.

Abstract

Introduction: Endoscopic ultrasonography guided tissue acquisition (EUS + TA) is used to provide a tissue diagnosis in patients with suspected pancreatic cancer. Key performance indicators (KPI) for these procedures are rate of adequate sample (RAS) and sensitivity for malignancy (SFM). Aim: assess practice variation regarding KPI of EUS + TA prior to resection of pancreatic carcinoma in the Netherlands. Patients and methods: Results of all EUS + TA prior to resection of pancreatic carcinoma from 2014–2018, were extracted from the national Dutch Pathology Registry (PALGA). Pathology reports were classified as: insufficient for analysis (b1), benign (b2), atypia (b3), neoplastic other (b4), suspected malignant (b5), and malignant (b6). RAS was defined as the proportion of EUS procedures yielding specimen sufficient for analysis. SFM was calculated using a strict definition (malignant only, SFM-b6), and a broader definition (SFM-b5+6). Results: 691 out of 1638 resected patients (42%) underwent preoperative EUS + TA. RAS was 95% (range 89–100%), SFM-b6 was 44% (20–77%), and SFM-b5+6 was 65% (53–90%). All centers met the performance target RAS>85%. Only 9 out of 17 met the performance target SFM-b5+6 > 85%. Conclusion: This nationwide study detected significant practice variation regarding KPI of EUS + TA procedures prior to surgical resection of pancreatic carcinoma. Therefore, quality improvement of EUS + TA is indicated.

Published
2023

41. Endoscopic ultrasonography-guided gastroenterostomy versus surgical gastrojejunostomy for palliation of malignant gastric outlet obstruction (ENDURO):study protocol for a randomized controlled trial

Author

Kastelijn, Janine B., van de Pavert, Yorick L., Besselink, Marc G., Fockens, Paul, Voermans, Rogier P., van Wanrooij, Roy L.J., de Wijkerslooth, Thomas R., Curvers, Wouter L., de Hingh, Ignace H.J.T., Bruno, Marco J., Koerkamp, Bas Groot, Patijn, Gijs A., Poen, Alexander C., van Hooft, Jeanin E., Inderson, Akin, Mieog, J. Sven D., Poley, Jan Werner, Bijlsma, Alderina, Lips, Daan J., Venneman, Niels G., Verdonk, Robert C., van Dullemen, Hendrik M., Hoogwater, Frederik J.H., Frederix, Geert W.J., Molenaar, I. Quintus, Welsing, Paco M.J., Moons, Leon M.G., van Santvoort, Hjalmar C., Vleggaar, Frank P., Kastelijn, Janine B., van de Pavert, Yorick L., Besselink, Marc G., Fockens, Paul, Voermans, Rogier P., van Wanrooij, Roy L.J., de Wijkerslooth, Thomas R., Curvers, Wouter L., de Hingh, Ignace H.J.T., Bruno, Marco J., Koerkamp, Bas Groot, Patijn, Gijs A., Poen, Alexander C., van Hooft, Jeanin E., Inderson, Akin, Mieog, J. Sven D., Poley, Jan Werner, Bijlsma, Alderina, Lips, Daan J., Venneman, Niels G., Verdonk, Robert C., van Dullemen, Hendrik M., Hoogwater, Frederik J.H., Frederix, Geert W.J., Molenaar, I. Quintus, Welsing, Paco M.J., Moons, Leon M.G., van Santvoort, Hjalmar C., and Vleggaar, Frank P.

Abstract

Background: Malignant gastric outlet obstruction (GOO) is a debilitating condition that frequently occurs in patients with malignancies of the distal stomach and (peri)ampullary region. The standard palliative treatment for patients with a reasonable life expectancy and adequate performance status is a laparoscopic surgical gastrojejunostomy (SGJ). Recently, endoscopic ultrasound-guided gastroenterostomy (EUS-GE) emerged as a promising alternative to the surgical approach. The present study aims to compare these treatment modalities in terms of efficacy, safety, and costs. Methods: The ENDURO-study is a multicentre, open-label, parallel-group randomized controlled trial. In total, ninety-six patients with gastric outlet obstruction caused by an irresectable or metastasized malignancy will be 1:1 randomized to either SGJ or EUS-GE. The primary endpoint is time to tolerate at least soft solids. The co-primary endpoint is the proportion of patients with persisting or recurring symptoms of gastric outlet obstruction for which a reintervention is required. Secondary endpoints are technical and clinical success, quality of life, gastroenterostomy dysfunction, reinterventions, time to reintervention, adverse events, quality of life, time to start chemotherapy, length of hospital stay, readmissions, weight, survival, and costs. Discussion: The ENDURO-study assesses whether EUS-GE, as compared to SGJ, results in a faster resumption of solid oral intake and is non-inferior regarding reinterventions for persistent or recurrent obstructive symptoms in patients with malignant GOO. This trial aims to guide future treatment strategies and to improve quality of life in a palliative setting. Trial registration: International Clinical Trials Registry Platform (ICTRP): NL9592. Registered on 07 July 2021.

Published
2023

42. Short-term and Long-term Outcomes of a Disruption and Disconnection of the Pancreatic Duct in Necrotizing Pancreatitis: A Multicenter Cohort Study in 896 Patients

Author

MS MDL 1, Cancer, MS CGO, Timmerhuis, Hester C., Van Dijk, Sven M., Hollemans, Robbert A., Sperna Weiland, Christina J., Umans, Devica S., Boxhoorn, Lotte, Hallensleben, Nora H., Van Der Sluijs, Rogier, Brouwer, Lieke, Van Duijvendijk, Peter, Kager, Liesbeth, Kuiken, Sjoerd, Poley, Jan Werner, De Ridder, Rogier, Römkens, Tessa E.H., Quispel, Rutger, Schwartz, Matthijs P., Tan, Adriaan C.I.T.L., Venneman, Niels G., Vleggaar, Frank P., Van Wanrooij, Roy L.J., Witteman, Ben J., Van Geenen, Erwin J., Molenaar, I. Quintus, Bruno, Marco J., Van Hooft, Jeanin E., Besselink, Marc G., Voermans, Rogier P., Bollen, Thomas L., Verdonk, Robert C., Van Santvoort, Hjalmar C., MS MDL 1, Cancer, MS CGO, Timmerhuis, Hester C., Van Dijk, Sven M., Hollemans, Robbert A., Sperna Weiland, Christina J., Umans, Devica S., Boxhoorn, Lotte, Hallensleben, Nora H., Van Der Sluijs, Rogier, Brouwer, Lieke, Van Duijvendijk, Peter, Kager, Liesbeth, Kuiken, Sjoerd, Poley, Jan Werner, De Ridder, Rogier, Römkens, Tessa E.H., Quispel, Rutger, Schwartz, Matthijs P., Tan, Adriaan C.I.T.L., Venneman, Niels G., Vleggaar, Frank P., Van Wanrooij, Roy L.J., Witteman, Ben J., Van Geenen, Erwin J., Molenaar, I. Quintus, Bruno, Marco J., Van Hooft, Jeanin E., Besselink, Marc G., Voermans, Rogier P., Bollen, Thomas L., Verdonk, Robert C., and Van Santvoort, Hjalmar C.

Published
2023

43. Colonoscopic-assisted laparoscopic wedge resection versus segmental colon resection for benign colonic polyps: a comparative cost analysis

Author

MS MDL 1, Cancer, Unit Opleiding MDL, Hanevelt, Julia, Leicher, Laura W, Moons, Leon M G, Vleggaar, Frank P, Huisman, Jelle F, van Westreenen, Henderik L, de Vos Tot Nederveen Cappel, Wouter H, MS MDL 1, Cancer, Unit Opleiding MDL, Hanevelt, Julia, Leicher, Laura W, Moons, Leon M G, Vleggaar, Frank P, Huisman, Jelle F, van Westreenen, Henderik L, and de Vos Tot Nederveen Cappel, Wouter H

Published
2023

44. Endoscopic embolization of a refractory bronchobiliary fistula by endoscopic retrograde cholangiography using coils and Histoacryl

Author

MS MDL 1, MS Radiologie, Other research (not in main researchprogram), Circulatory Health, Cancer, Didden, Paul, Bruijnen, Rutger C G, Vonken, Evert-Jan P A, Vleggaar, Frank P, MS MDL 1, MS Radiologie, Other research (not in main researchprogram), Circulatory Health, Cancer, Didden, Paul, Bruijnen, Rutger C G, Vonken, Evert-Jan P A, and Vleggaar, Frank P

Published
2023

45. Risk Factors for Cholangitis After Pancreatoduodenectomy: A Systematic Review

Author

MS CGO, Trialbureau Beeld, Cancer, MS HOD, MS MDL 1, Salaheddine, Youcef, Henry, Anne Claire, Daamen, Lois A, Derksen, Wouter J M, van Lienden, Krijn P, Molenaar, I Quintus, van Santvoort, Hjalmar C, Vleggaar, Frank P, Verdonk, Robert C, MS CGO, Trialbureau Beeld, Cancer, MS HOD, MS MDL 1, Salaheddine, Youcef, Henry, Anne Claire, Daamen, Lois A, Derksen, Wouter J M, van Lienden, Krijn P, Molenaar, I Quintus, van Santvoort, Hjalmar C, Vleggaar, Frank P, and Verdonk, Robert C

Published
2023

46. Systematic review with meta-analysis: branched-chain amino acid supplementation in liver disease

Author

Afdeling Dietetiek, Cancer, Epi Kanker Team C, MS Hoofd-Hals Chirurgische Oncologie, VS-DIGD, MS MDL 1, Infection & Immunity, van Dijk, Anne M, Bruins Slot, Alexandra S, Portincasa, Piero, Siegerink, Sebastiaan N, Chargi, Najiba, Verstraete, Carina J R, Bruijne, Joep de, Vleggaar, Frank P, van Erpecum, Karel J, Afdeling Dietetiek, Cancer, Epi Kanker Team C, MS Hoofd-Hals Chirurgische Oncologie, VS-DIGD, MS MDL 1, Infection & Immunity, van Dijk, Anne M, Bruins Slot, Alexandra S, Portincasa, Piero, Siegerink, Sebastiaan N, Chargi, Najiba, Verstraete, Carina J R, Bruijne, Joep de, Vleggaar, Frank P, and van Erpecum, Karel J

Published
2023

47. Clinical Outcomes of Biliary Drainage in Patients with Malignant Biliary Obstruction Caused by Colorectal Cancer Metastases

Author

Cancer, MS MDL 1, Arts-assistenten Radiologie, MS Radiologie, MS Medische Oncologie, Kastelijn, Janine B, Moons, Leon M G, Kist, Jakob W, Prince, Jip F, van Leeuwen, Maarten S, Koopman, Miriam, Vleggaar, Frank P, Cancer, MS MDL 1, Arts-assistenten Radiologie, MS Radiologie, MS Medische Oncologie, Kastelijn, Janine B, Moons, Leon M G, Kist, Jakob W, Prince, Jip F, van Leeuwen, Maarten S, Koopman, Miriam, and Vleggaar, Frank P

Published
2023

49. Short- and long-term outcomes of a disruption and disconnection of the pancreatic duct in necrotizing pancreatitis: a multicenter cohort study in 896 patients : Disrupted pancreatic duct in acute pancreatitis

Author

Timmerhuis, Hester C, van Dijk, Sven M, Hollemans, Robbert A, Sperna Weiland, Christina J, Umans, Devica S, Boxhoorn, Lotte, Hallensleben, Nora H, van der Sluijs, Rogier, Brouwer, Lieke, van Duijvendijk, Peter, Kager, Liesbeth, Kuiken, Sjoerd, Poley, Jan-Werner, de Ridder, Rogier, Römkens, Tessa, Quispel, Rutger, Schwartz, Matthijs P, Tan, Adriaan C I T L, Venneman, Niels G, Vleggaar, Frank P, van Wanrooij, Roy L J, Witteman, Ben J, van Geenen, Erwin, Molenaar, I Quintus, Bruno, Marco J, van Hooft, Jeanin E, Besselink, Marc G, Voermans, Rogier P, Bollen, Thomas L, Verdonk, Robert C, van Santvoort, Hjalmar C, RS: FHML non-thematic output, MUMC+: MA Maag Darm Lever (9), and Interne Geneeskunde

Abstract

INTRODUCTION:Necrotizing pancreatitis may result in a disrupted or disconnected pancreatic duct (DPD) with the potential for long-lasting negative impact on a patient's clinical outcome. There is a lack of detailed data on the full clinical spectrum of DPD, which is critical for the development of better diagnostic and treatment strategies.METHODS:We performed a long-term post hoc analysis of a prospectively collected nationwide cohort of 896 patients with necrotizing pancreatitis (2005-2015). The median follow-up after hospital admission was 75 months (P25-P75: 41-151). Clinical outcomes of patients with and without DPD were compared using regression analyses, adjusted for potential confounders. Predictive features for DPD were explored.RESULTS:DPD was confirmed in 243 (27%) of the 896 patients and resulted in worse clinical outcomes during both the patient's initial admission and follow-up. During hospital admission, DPD was associated with an increased rate of new-onset intensive care unit admission (adjusted odds ratio [aOR] 2.52; 95% confidence interval [CI] 1.62-3.93), new-onset organ failure (aOR 2.26; 95% CI 1.45-3.55), infected necrosis (aOR 4.63; 95% CI 2.87-7.64), and pancreatic interventions (aOR 7.55; 95% CI 4.23-13.96). During long-term follow-up, DPD increased the risk of pancreatic intervention (aOR 9.71; 95% CI 5.37-18.30), recurrent pancreatitis (aOR 2.08; 95% CI 1.32-3.29), chronic pancreatitis (aOR 2.73; 95% CI 1.47-5.15), and endocrine pancreatic insufficiency (aOR 1.63; 95% CI 1.05-2.53). Central or subtotal pancreatic necrosis on computed tomography (OR 9.49; 95% CI 6.31-14.29) and a high level of serum C-reactive protein in the first 48 hours after admission (per 10-point increase, OR 1.02; 95% CI 1.00-1.03) were identified as independent predictors for developing DPD.DISCUSSION:At least 1 of every 4 patients with necrotizing pancreatitis experience DPD, which is associated with detrimental, short-term and long-term interventions, and complications. Central and subtotal pancreatic necrosis and high levels of serum C-reactive protein in the first 48 hours are independent predictors for DPD.

Published
2023

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