3,265 results on '"Vlad, V"'
Search Results
2. Can the morphological traits of benthic testate amoebae in a freshwater lake be indicators of depth and environmental conditions?
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Sysoev, Vlad V., Seleznev, Dmitry G., Tran, Hoan Q., Reshetnikov, Fedor Y., and Tikhonenkov, Denis V.
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- 2024
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3. Treatment preferences in diverticulitis are common and rarely change after a clinic visit
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Anna A. Melio, Meredith Johnson, Jennifer A. Kaplan, Ravi Moonka, and Vlad V. Simianu
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Diverticulitis ,Surgical management ,Treatment preferences ,Colorectal surgery ,Surgery ,RD1-811 - Abstract
With the increasing prevalence of diverticulitis, professional guidelines encourage the individualization of treatment. However, the frequency of treatment preferences of both surgeons, and patients, and the resultant impact of that preference on diverticulitis management is underexplored. We reviewed 27 consecutive patient visits of 3 colorectal surgeons at our institution to evaluate factors that drove their treatment, as well as their equipoise for patient randomization into medical or surgical treatments. Using standardized pre- and post-visit questionnaires, we investigated the impact of the clinic visit on treatment recommendations. Our results demonstrate that our surgeons have a practice bias towards complicated disease, and have a preference towards operative management of diverticulitis, in both complicated and uncomplicated disease. This preference was frequently unchanged after clinic visit, which has implications for guiding truly shared decision making, as it continues to be the recommendation.
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- 2024
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4. Clinician perceptions on barriers and facilitators to 1‐year surveillance colonoscopy completion in survivors of colorectal cancer
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C. Natasha Kwendakwema, Talor Hopkins, Ari Bell‐Brown, Vlad V. Simianu, Veena Shankaran, and Rachel B. Issaka
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barriers ,colonoscopy ,colorectal cancer ,facilitators ,surveillance ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
Abstract Introduction Colorectal cancer (CRC) is the second leading cause of cancer deaths in the United States. Surveillance colonoscopy is recommended 1‐year after surgical resection for patients with stage I‐III CRC; however, only 18%–61% of CRC survivors complete this test. This study describes clinician‐identified barriers and facilitators to surveillance colonoscopy among CRC survivors. Methods We conducted semi‐structured interviews with clinicians until thematic saturation was achieved. Interviews were analyzed using the social cognitive theory. Results Thirteen clinicians were interviewed, and all identified health system‐level barriers to surveillance colonoscopy completion; the most common being fragmented care due to patients receiving care across many health systems. Clinicians also identified social determinants of health barriers (e.g., geographical distance between patients and health systems) to 1‐year surveillance colonoscopy completion. Conclusions Clinicians identified several potentially modifiable barriers to 1‐year surveillance colonoscopy completion which, if addressed, could improve post‐treatment care and outcomes among stage I‐III CRC survivors.
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- 2024
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5. Power Has Pitfalls: (In)accuracy of Administrative Data for Nonoperative Management of Appendicitis
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Laudon, Aksel D., Beaulieu-Jones, Brendin R., Gitonga, Baraka, Yang, Frank F., Chen, Elizabeth, Flum, Dave R., Lerner, Kasey, Evans, Heather L., Thompson, Lauren, Azar, Faris K., Charboneau, Alex, Simianu, Vlad V., Sanchez, Sabrina E., and Drake, F. Thurston
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- 2024
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6. Contemporary management of anorectal fistula
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Hyung Chan Kim, MD and Vlad V. Simianu, MD MPH
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Anorectal fistula ,crohn's disease ,Seton ,Fistulotomy ,Surgery ,RD1-811 - Abstract
Anorectal fistula is a common, chronic condition, and is primarily managed surgically. Herein, we provide a contemporary review of the relevant etiology and anatomy anorectal fistula, treatment recommendations that summarize relevant outcomes and alternative considerations, in particular when to refer to a fistula expert.
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- 2024
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7. Characterizing Regionalization of Inflammatory Bowel Disease Hospitalizations and Operations in Washington State
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Stovall, Stephanie L., Soriano, Celine R., Kaplan, Jennifer A., La Selva, Danielle, Lord, James, Moonka, Ravi, Zisman, Timothy L., and Simianu, Vlad V.
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- 2023
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8. Optical absorption of supramolecular aggregates of vanadyl etioporphyrin-III in solutions and thin films
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Koptyaev, Andrey I., Rychikhina, Ekaterina D., Zhabanov, Yury A., Travkin, Vlad V., and Pakhomov, Georgy L.
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- 2024
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9. Unraveling the adaptive strategies of Mycoplasma hominis through proteogenomic profiling of clinical isolates
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Olga V. Pobeguts, Maria A. Galaymina, Kirill V. Sikamov, Diana R. Urazaeva, Alexander S. Avshalumov, Maria V. Mikhailycheva, Vlad V. Babenko, Igor P. Smirnov, and Alexey Yu. Gorbachev
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Mycoplasma hominis ,clinical isolates ,mini colonies ,phenotype switch ,proteogenomic analysis ,adaptation to host ,Microbiology ,QR1-502 - Abstract
IntroductionMycoplasma hominis (M. hominis) belongs to the class Mollicutes, characterized by a very small genome size, reduction of metabolic pathways, including transcription factors, and the absence of a cell wall. Despite this, they adapt well not only to specific niches within the host organism but can also spread throughout the body, colonizing various organs and tissues. The adaptation mechanisms of M. hominis, as well as their regulatory pathways, are poorly understood. It is known that, when adapting to adverse conditions, Mycoplasmas can undergo phenotypic switches that may persist for several generations.MethodsTo investigate the adaptive properties of M. hominis related to survival in the host, we conducted a comparative phenotypic and proteogenomic analysis of eight clinical isolates of M. hominis obtained from patients with urogenital infections and the laboratory strain H-34.ResultsWe have shown that clinical isolates differ in phenotypic features from the laboratory strain, form biofilms more effectively and show resistance to ofloxacin. The comparative proteogenomic analysis revealed that, unlike the laboratory strain, the clinical isolates possess several features related to stress survival: they switch carbon metabolism, activating the energetically least advantageous pathway of nucleoside utilization, which allows slowing down cellular processes and transitioning to a starvation state; they reconfigure the repertoire of membrane proteins; they have integrative conjugative elements in their genomes, which are key mediators of horizontal gene transfer. The upregulation of the methylating subunit of the restriction-modification (RM) system type I and the additional components of RM systems found in clinical isolates suggest that DNA methylation may play a role in regulating the adaptation mechanisms of M. hominis in the host organism. It has been shown that based on the proteogenomic profile, namely the genome sequence, protein content, composition of the RM systems and additional subunits HsdM, HsdS and HsdR, composition and number of transposable elements, as well as the sequence of the main variable antigen Vaa, we can divide clinical isolates into two phenotypes: typical colonies (TC), which have a high growth rate, and atypical (aTC) mini-colonies, which have a slow growth rate and exhibit properties similar to persisters.DiscussionWe believe that the key mechanism of adaptation of M. hominis in the host is phenotypic restructuring, leading to a slowing down cellular processes and the formation of small atypical colonies. This is due to a switch in carbon metabolism and activation the pathway of nucleoside utilization. We hypothesize that DNA methylation may play a role in regulating this switch.
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- 2024
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10. Where are Colorectal Resections being Performed? Colon and Rectal Cancer Operations in Washington State are Decentralized
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Soriano, Celine R., Evans, Ethan, Lin, Bruce S., Kaplan, Jennifer A., Post, Amber B., Bahnson, Henry T., and Simianu, Vlad V.
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- 2023
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11. Implementation of a structured robotic colorectal curriculum for general surgery residents
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Unruh, Kenley, Stovall, Stephanie, Chang, Lily, Deal, Shanley, Kaplan, Jennifer A., Moonka, Ravi, and Simianu, Vlad V.
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- 2023
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12. Contemporary management of anorectal fistula
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Kim, Hyung Chan and Simianu, Vlad V.
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- 2024
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13. Age- and Population-Adjusted Trends in Inpatient Surgical Management of Vaginal Prolapse, Rectal Prolapse, and Concurrent Vaginal and Rectal Prolapse Surgery
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Justina Tam, Hanna G. Koenig, Celine R. Soriano, Alvaro Lucioni, Jennifer A. Kaplan, Kathleen C. Kobashi, Vlad V. Simianu, and Una J. Lee
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concurrent surgery ,rectal prolapse ,vaginal prolapse ,multidisciplinary care ,Diseases of the genitourinary system. Urology ,RC870-923 - Abstract
ObjectiveTo report age- and population-adjusted trends in the prevalence of inpatient vaginal prolapse (VP), rectal prolapse (RP), and concurrent VP/RP surgical procedures in women in Washington State over a 12-year period. MethodsThe Comprehensive Hospital Abstract Reporting System, an inpatient claims database, was queried for female patients aged 20 years or older with a diagnosis of VP and/or RP and associated surgical procedures from 2008 to 2019. Rates for female patients were adjusted by age and population based on census results. ResultsBetween 2008 and 2019, inpatient admissions for concurrent VP/RP surgery remained stable, with adjusted rates ranging from 1.42 to 3.38 per 100 000, with a majority performed in patients < 80 years old. The population-adjusted rate of inpatient RP repairs remained stable at 3.12 to 5.14 per 100 000. The population-adjusted rate of inpatient VP repairs decreased dramatically, from 81.79 to 6.96 per 100 000. ConclusionsThe rate of inpatient RP and combined RP/VP surgical procedures was low and remained stable, while inpatient VP surgical repairs decreased substantially. Since the dataset is limited to inpatient surgery, this trend may reflect a shift to outpatient settings for VP surgeries. Nationally in the United States, there has been a trend toward multidisciplinary surgical management of concurrent VP/RP. However, this same trend does not appear to be reflected in Washington State, suggesting that nationwide trends may not be reflective of trends within each state. Further study is needed to understand how and why local trends in the management concurrent VP/RP may differ from national trends, and potentially improve concurrent VP/RP management using multidisciplinary approaches.
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- 2023
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14. Selective type & screen for elective colectomy based on a transfusion risk score may generate substantial cost savings
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Booth, Alexander T., Allen, Shelby, Simianu, Vlad V., Jensen, Christine C., Schermerhorn, Marc L., George, Virgilio V., and Curran, Thomas
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- 2022
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15. Magnetic susceptibility of soils as an ambiguous climate proxy for paleoclimate reconstructions
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Alekseev, Andrey O., Shary, Peter A., and Malyshev, Vlad V.
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- 2023
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16. Elective surgery system strengthening: development, measurement, and validation of the surgical preparedness index across 1632 hospitals in 119 countries
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Glasbey, James C, Abbott, Tom EF, Ademuyiwa, Adesoji, Adisa, Adewale, AlAmeer, Ehab, Alshryda, Sattar, Arnaud, Alexis P, Bankhead-Kendall, Brittany, Abou Chaar, M K, Chaudhry, Daoud, Costas-Chavarri, Ainhoa, Cunha, Miguel F, Davies, Justine I, Desai, Anant, Elhadi, Muhammed, Fiore, Marco, Fitzgerald, James Edward, Fourtounas, Maria, Fowler, Alex James, Futaba, Kay, Gallo, Gaetano, Ghosh, Dhruva, Gujjuri, Rohan R, Hamilton, Rebecca, Haque, Parvez, Harrison, Ewen M, Hutchinson, Peter, Hyman, Gabriella, Isik, Arda, Jayarajah, Umesh, Kaafarani, Haytham MA, Kadir, Bryar, Lawani, Ismail, Lederhuber, Hans, Li, Elizabeth, Löffler, Markus W, Lorena, Maria Aguilera, Mann, Harvinder, Martin, Janet, Mazingi, Dennis, McClain, Craig D, McLean, Kenneth A, Meara, John G, Ramos-De La Medina, Antonio, Mengesha, Mengistu, Minaya, Ana, Modolo, Maria Marta, Moore, Rachel, Morton, Dion, Nepogodiev, Dmitri, Ntirenganya, Faustin, Pata, Francesco, Pearse, Rupert, Picciochi, Maria, Pinkney, Thomas, Pockney, Peter, van Ramshorst, Gabrielle H, Richards, Toby, Roslani, April Camilla, Satoi, Sohei, Sayyed, Raza, Shaw, Richard, Simões, Joana FF, Smart, Neil, Sullivan, Richard, Sund, Malin, Sundar, Sudha, Tabiri, Stephen, Taylor, Elliott H, Venn, Mary L, Wickramasinghe, Dakshitha, Wright, Naomi, Yip, Sebastian Bernardo Shu, Bhangu, Aneel, Omar, Omar, Harrison, Ewen, Bhangu, Aneel A, Siaw-Acheampong, Kwabena, Benson, Ruth A, Bywater, Edward, Dawson, Brett E, Evans, Jonathan P, Heritage, Emily, Jones, Conor S, Kamarajah, Sivesh K, Khatri, Chetan, Khaw, Rachel A, Keatley, James M, Knight, Andrew, Lawday, Samuel, Mann, Harvinder S, Marson, Ella J, Mckay, Siobhan C, Mills, Emily C, Pellino, Gianluca, Tiwari, Abhinav, Trout, Isobel M, Wilkin, Richard JW, Abukhalaf, Sadi, Adamina, Michel, Ademuyiwa, Adesoji O, Agarwal, Arnav, Akkulak, Murat, Alameer, Ehab, Alderson, Derek, Alakaloko, Felix, Albertsmeier, Markus, Alser, Osaid, Alshaar, Muhammad, Augestad, Knut Magne, Ayasra, Faris, Azevedo, José, Bankhead-Kendall, Brittany K, Barlow, Emma, Beard, David, Blanco-Colino, Ruth, Brar, Amanpreet, Minaya-Bravo, Ana, Breen, Kerry A, Bretherton, Chris, Buarque, Igor Lima, Burke, Joshua, Caruana, Edward J, Chaar, Mohammad, Chakrabortee, Sohini, Christensen, Peter, Cox, Daniel, Cukier, Moises, Davidson, Giana H, Di Saverio, Salomone, Drake, Thomas M, Edwards, John G, Emile, Sameh, Farik, Shebani, Ford, Samuel, Garmanova, Tatiana, Gomes, Gustavo Mendonça Ataíde, Grecinos, Gustavo, Griffiths, Ewen A, Gruendl, Magdalena, Halkias, Constantine, Hisham, Intisar, Hutchinson, Peter J, Hwang, Shelley, Jenkinson, Michael D, Jonker, Pascal, Keller, Debby, Kolias, Angelos, Kruijff, Schelto, Leventoglu, Sezai, Litvin, Andrey, Loehrer, Andrew, Major, Piotr, Mashbari, Hassan N, Metallidis, Symeon, Mohan, Helen M, Moszkowicz, David, Moug, Susan, Ng-Kamstra, Joshua S, Maimbo, Mayaba, Negoi, Ionut, Niquen, Milagros, Olivos, Maricarmen, Oussama, Kacimi, Outani, Oumaima, Parreno-Sacdalanm, Marie Dione, Rivera, Carlos Jose Perez, Pinkney, Thomas D, Plas, Willemijn van der, Qureshi, Ahmad, Radenkovic, Dejan, Revell, Elliot J, Roberts, Keith, Roslani, April C, Rutegård, Martin, Segura-Sampedro, Juan José, Santos, Irène, Schache, Andrew, Schnitzbauer, Andreas A, Seyi-Olajide, Justina O, Sharma, Neil, Shaw, Catherine A, Shu, Sebastian, Soreide, Kjetil, Spinelli, Antonino, Stewart, Grant D, Townend, Philip, Tsoulfas, Georgios, Vidya, Raghavan, Vimalachandran, Dale, Warren, Oliver J, Wedderburn, Duane, EuroSurg, NA, European Society of Coloproctology (ESCP), NA, Global Initiative for Children's Surgery, NA, GlobalSurg, NA, GlobalPaedSurg, NA, ItSURG, NA, PTSurg, NA, SpainSurg, NA, Italian Society of Colorectal Surgery, NA, Association of Surgeons in Training, NA, Irish Surgical Research Collaborative (ISRC), NA, Transatlantic Australasian Retroperitoneal Sarcoma Working, NA, Italian Society of Surgical Oncology, NA, Booth, Lesley, Barker, Margaret, Barker, Neil, Cooke, Shirley, Doré, Suzanne, Horwood, Nigel, Runigamugabo, Emmy, Weir, Carrie Tierney, Bahrami-Hessari, Mike, Riaz, Asad, Shah, Jaffer, Safi, Mohammed, Thereska, Dariel, Dajti, Irida, Cheddadi, Riadh, Tidjane, Anisse, Quinteros, Carlos A, khelfaoui, Ahmed, Salem, Khalifa M, Riffi, Omar, Kacimi, Salah Eddine O, Loudjedi, Salim, Damerdji, Tidjani, Pantoja Pachajoa, Diana A, Palacios Huatuco, René M, Alvarez, Fernando A, Doniquian, Alejandro M, Abeldaño Zuñiga, Roberto A, Schlottmann, Francisco, Cobos, Carlos M, Gigena, Cecilia, Forneris, Agustin Albani, Duro, Agustin, García-Mansilla, Agustín M, Busnelli, Virginia Cano, Poggi, Catalina, Mercado, Pedro L, González, Marcos, Castro Lalin, Agustina F, Mayer, Horacio F, Brandariz, Rodrigo, Slullitel, Pablo A, Boudou, Rocio, Lobos, Pablo A, Uffelmann, María C, Petersen, Maria L, Luzzi, Emilia, Padilla Lichtenberger, Fernando L, Crespi Amor, María S, Zarratea, Celeste S, Esteves, Tomas A, Gemelli, Nicolas A, Tirapegui, Sebastián, Liyo, Juan, Scherñuk, Jordán, Boccalatte, Luis A, Balmaceda, Ruben D, D'Addino, Jose L, Caubet, María M, Calderón Arancibia, José A, Chwat, Carina, Morris, Brian, Avellaneda, Nicolas, Pedraza Salazar, Ivana I, Eskinazi, Diego G, Vargas, Lara, Muriel, María E, Lucchini, Sergio M, Gosselink, Martijn P, Davis, Amelia L, Barker, John C, Qin, Kirby R, Proud, David M, Cox, Daniel RA, Goh, Su Kah, Liu, David S, Wu, Damien M, Merrett, Neil D, Badiani, Sarit S, Sengupta, Shomik, Jain, Anshini, Steen, Christopher J, Wong, Enoch, Ip, Christopher CK, Leaning, Matthew G, McCartney, Conor B, Gananadha, Sivakumar, Yeap, Evie FW, Stevens, Sean G, Vu, Anh N, Martin, Sarah A, Stanley, Guy H M, Watson, David I, Townend, Philip J, Young, Thomas K, Cox, Georgia T, Dawson, Amanda C, Laura, Sharon E, Lun, Elizabeth W Y, Liang, Ina X, O'Neill, Christine J, Lott, Natalie J, Chuan, Alwin, Saravanan, SK, Gundara, Justin, Ong, Bee Shan, Nataraja, Ramesh M, Pacilli, Maurizio, Foley, Daniel M, Ooi, Geraldine J, Traeger, Luke, MacDermid, Ewan, Daruwalla, Jurstine, Hodgson, Russell, Heriot, Alexander G, Mulligan, Christopher S, Blefari, Nicholas D A, Purcell, Shaun S, Frankel, Adam J, Guerra, Glen R, Tefay, Joan S, Liang, Rhea W Y, Kroon, Hidde M, Farfus, Anthony W, Warren, Leigh R, Roy, Jennifer M, Whitfield, Robert J, Moller, Cea-Cea B, Davis, Sean S, Sammour, Tarik, Lam, Yick Ho, Kour, Kevin, Gan, Siang Wei, Coventry, Brendon J, Dawson, Joseph A, Batstone, Martin D, King, Sebastian K, Scott, Nathan J, Foo, Jonathan W, Shepherd, Talia, Page, Richard S, Choong, Peter F, Badgery, Henry E, Chong, Lynn, Taylor, Lillian, Hii, Michael W, Wright, Gavin M, Kong, Joseph CH, Watson, Matthew M, Bock, Jacob, Lidder, Surjit S, Elias, Patrick, Kanavathy, Sathisvaran, Koh, Cherry E, Chennakesavan, Srinivas Kondalsamy, Panuganti, Vishwakar, Latif, Haider, Yeung, Justin MC, Besson, Alex J, Tse, Eunice Q Y, Pitcher, Meron E, Taylor, Danielle L, Nahm, Christopher B, Lim, Alicia, Tree, Kevin, Aigner, Felix, Dawoud, Christopher, Foessleitner, Philipp, Zimmermann, Matthias, Wiedemann, Dominik, Findl, Oliver, Messner, Franka, Bauer, Marlies, Nägele, Felix, Kronberger, Irmgard E, Öfner, Dietmar, Härter, Bettina, Bicz, Nina Ru B, Zwittag, Paul M, Poier, Nikolaus, Navarro, Francisco Ruiz, Zebuhr, Yorck A, Köglberger, Paul, Wiesinger, Clemens G, Mathew, Erwin, Trivik-Barrientos, Felipe, Königsrainer, Ingmar, Djedovic, Gabriel, Cohnert, Tina U, Lumenta, David B, Singer, Georg, Leithner, Andreas, Kamolz, Lars-Peter, Andrianakis, Alexandros, Puchwein, Paul, Mikalauskas, Saulius, Kirchweger, Patrick, Függer, Reinhold, Mittermair, Christof, Russe, Elisabeth, Paal, Peter, Grünbart, Martin, de Cillia, Michael, Weiss, Helmut G, Steiner, Florian, Binder, Alf Dorian, Samadov, Elgun, Ibrahimli, Arturan, Muslumov, Gurbankhan, Bayramov, Nuru Y, Saunders, Jada M, Almoosa, Noora, Haj-Ibrahim, Huzifa, Maresch, Martin, Ezzdean, Weaam K, Juma, Isam M, Hasan, Layla H, Haider, Fayza HA, Alfaqawi, Ghassan Salman, Alam, Mohammed S, Islam, Shahnoor, Basher, AKM K, Mitul, Ashrarur Rahman, Islam, Nazmul, Oosterkamp, Antje E, Ahmed, Tanveer, Hannan, M Jafrul, Padmore, Greg M, Doyle, Alex F, LaCorbiniere, Karisha L, Boyce, Rico D R, Ragoobar, Paul T, Walkes, Keisha M Y, Haynes, Amelia A, Corbin, Sasha M, Litvina, Yauheniya A, Makhmudov, Anvar, Strypstein, Sébastien, Dhondt, Bert, Rasschaert, Ricky, Farid, Yasser, Wahib, El Mahdi, Pigeolet, Manon, Belle, Koen Van, De Wachter, Stefan, Komen, Niels, Vandeputte, Mathieu PJ, Jansen, Yanina JL, Stijns, Jasper, Eynde, Jef Van den, Olowo, Benedicte I, Feraudy, Israel C, Dragisic, Vedran, Martinovic, Vlatka, Barišić, Tatjana, Penava, Nikolina, Hudic, Igor, Delibegovic, Samir, Bogdanović, Gordana, Grgić, Gordana, Cerovac, Anis, Cerovac, Elmedina, Bedada, Alemayehu G, Baiocchi, Glauco, Wainstein, Alberto, Moisés, Elaine Christine D, Zani, Ana Carolina Tagliatti, de Campos Prado, Caio Antonio, Panis, Carolina, Rech, Daniel, Soares da Silva, Ruan Gabriel, Joviliano, Edwaldo E, Rezende, Ricardo F, Reis, Igor G N, Pires, Robinson E S, Christiano, Adriana Borgonovi, Consani, Heitor F X, Pugliesi, Felipe G, Takeda, Flavio R, Mariani, Alessandro W, Valadares, Ricardo J B, Andreollo, Nelson A, Lopes, Luiz Roberto, Tonello, Cristiano, Alonso, Nivaldo, dos Santos, Carlos Ferreira, Lima, Leonardo S, Salgado, Wilson, Pereira, Thiago H S, Gatti, Arthur Paredes, Oliva, Ramon N L, Nardi, Caroline N, Sousa, Alvaro F L, Ribeiro, Ivonizete P, Carvalho, Herica E F, Oliveira, Layze B, Schneider, Guilherme, Casteleins, William Augusto, Silva, Larissa M, Gomes, Carlos Augusto, da Cunha Viana Júnior, Alonço, Cruz, Ricardo P, Gomes, Gustavo MA, Buarque, Igor L, Barros, Aldo V, Marangon, Gustavo B, Flumignan, Ronald LG, Nakano, Luís CU, Pascoal, Patrícia IF, Santos, Brena C, Kuramoto, Danielle AB, Correia, Rebeca M, Amaral, Fabio CF, Flumignan, Carolina DQ, Dussán-Sarria, Jairo A, Simões, Romeo L, Amorim, Robson L, Silva, Jeancarllo S, Lyra Junior, Humberto F, Julio, Nathalia S, Gerber, Marlus T, dos Santos, José Mauro, de Oliveira, Joao Carlos C, Palamim, Camila VC, Marson, Fernando AL, Gomes, Iolanda M, Oliveira, Priscila R, Lima, Ana Lucia L M, Carvalho, Vladimir C, Silva, Jorge S, NA, Ulysses Ribeiro, Laporte, Gustavo Andreazza, Gonçalves, Mateus Capuzzo, Botacin, Lais S, Avelino, Melissa AG, Brito, Luiz Gustavo O, Hristova, Evguenia T, Stoyanov, Vladislav Valentinov, Sakakushev, Boris E, Dardanov, Dragomir D, Sokolov, Manol B, Mehta, Ananya, Gyokova, Elitsa H, Abdullahi, Mohamed, Karamanliev, Martin P, Dimitrov, Dobromir D, Slavchev, Mihail T, Atanasov, Boyko Ch, Yotsov, Tsanko I, Hadzhiev, Dimitar Bozhidarov, Stock, Simon E, Nwegbu, Chukwuemeka Gerald, Tanyi, Tanyi John, Brown, James A, Arneja, Jugpal S, Lee, Susan M, Kancherla, Ramya, Kidane, Biniam, Champagne, Pierre-Olivier, Ma, Xiya, Munro, Allana, McKeen, Dolores M, Glinka, Juan, Vasarhelyi, Edward M, Subramani, Yamini, Alfaro, Hilda, Shah, Ushma J, Gonzalez, Nelson J, MacNeil, S Danielle, Nagappa, Mahesh, Malthaner, Richard A, Brackstone, Muriel, Alkhamesi, Nawar A, Qiabi, Mehdi, Arango-Ferreira, Camila, Prempeh, Agya B A, Dumitra, Sinziana, Spence, Richard T, Bedard, Eric LR, Luc, Jessica GY, Johnston, Brian R, Attabib, Najmedden, Persad, Amit RL, Das, Sunit, Khoshbin, Amir, Ladha, Karim S, Sankar, Ashwin, Teja, Bijan, Daza, Julian F, Chan, Veronica F, Baertschiger, Reto M, Zani, Augusto, Nessim, Carolyn, McIsaac, Daniel I, Singh, Mandeep, Behzadi, Abdollah, Dell, Angela J, Al Riyami, Salim M, Dajani, Khaled Z, Bigam, David, Manikala, Vinod K, Street, John T, Mayson, Kelly V, Wallis, Christopher J D, Mimica, Ximena, Villanueva, Julio, Altamirano, Roberto, Waissbluth, Sofia, Marín, Diego I, Fonseca, Bruno Catoia, Hodali, Andrés J, Ramos, Andrea I, Valenzuela, Marco A, Torres, Janina J, Song, Yi, Yang, Wah, Aldanakh, Abdullah, Alradhi, Mohammed, Lyu, Yidong, Chen, Yan, Fletcher, Angélica V, Camargo, Daniela, Casanova, Rafael Figueroa, Medina, Camilo Andres Caicedo, Bolivar, Dinimo, Garcia, Tatiana Carolina Beltran, Pedraza, Nestor F, Garcia-Lopez, Andrea, Patino-Jaramillo, Nasly G, Giron, Fernando A, Rivera, Carlos J- Perez, Nieto-Calvache, Albaro José, Ariza, Fredy, Orozco-Chamorro, Claudia Milena, Nanez, Maria A, Garces, Diana S, Figueroa, Luis M, Badiel, Marisol, Martinez, Delio F, Coll-Tello, Brenda, Camelo, Hector F, Montoya Casella, Antonio J, Ordoñez, Sebastian, Velez Sanchez, Paola A, Salcedo, Juan C, Villegas, Lina M, Holguín, Jorge A, Cardozo, Jesús Hernán Tovar, Perdomo, Jorman Harvey Tejada, Perdomo, Valentina Gutiérrez, Rivera-Rincon, Natalia A, Gomez, Paula Torres, Delgado-Nieto, Elena Leonor, Isaza-Restrepo, Andres, Vargas, Felipe, Vargas, Ana M, Castro, Arnulfo Andrade, Navarro, Jorge A, Vargas, Saul E, Calvache, Jose A, Mendoza-Arango, Maria C, Bernal, Jorge Luis Vélez, Gonzalez, Felipe O, šantak, Goran, Kirac, Iva, Kršul, Dorian, Versic, Ana Bosak, Augustin, Goran, Kulis, Tomislav, Kastelan, Zeljko, Hadzibegovic, Ana Danic, Grsic, Kresimir, Hudolin, Tvrtko, 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Kandaswamy, Anyaugo, Ngozi S, Wuraola, Obafemi K, Odejinmi, Funlayo, Craven, Joanna M, West, Charlotte L, Barter, Reece A, Navaratnam, Devaraj M, Malik, Shahbaz S, Mahendran, Vimaladhithan, Zilvetti, Miguel, Lovegrove, Richard E, Board, Tim N, Zeiton, Moez, Sarwar, Safdar A, Duff, Sarah E, Hsabo, Elmuiz A, Nugur, Ashwani Kumar, Morris, Richard M, Lala, Anil K, Kwan-Feinberg, Rita O, Ross, Samuel W, Dressler, Jeremy A, Evans, Faye M, Wason, Shaun E L, Vogel, Keianna R, Wang, Joanna C, Sulciner, Megan L, Hirji, Sameer, Raoof, Mustafa, Wolff, Christopher J, kent, Ilan, Turan, Alparslan, Teixeira, Pedro G, Olson, Kristofor A, Patel, Neil D, Krishnamoorthy, Vijay, Moris, Dimitrios, Rice, Henry E, Gabr, Hesham, Satoskar, Savni R, Castater, Christine A, Jmaileh, Manal, Payne, Rachel E, Kwon, David S, Aarabi, Shahram, Escobar, Pedro F, Kronenfeld, Joshua P, Dalton, Michael K, Etchill, Eric W, Haut, Elliott R, Vervoort, Dominique, Dehal, Ahmed, McKenney, Mark, Elkbuli, Adel, Gosain, Ankush, Abdelsattar, Zaid M, Naunheim, Matthew R, Burks, Ciersten A, Zhou, Allen S, Heng, Marilyn, Abohashem, Shady, Lozano-Calderón, Santiago A, Reisenauer, Janani S, Mouawad, Nicolas J, Diehl, Thomas M, Eriksson, Evert A, Marwaha, Jayson S, Schroeppel, Thomas J, LaRocca, Christopher J, Chang, Grace H, Hassan, Romana, Nosanov, Lauren B, Rickard, Jennifer L, Avraham, Jacob B, Petrone, Patrizio, Sferra, Joseph J, Hadaya, Joseph, Mead, Brittany S, Hauptman, Jason S, Ahmad, Maleeha, Meola, Antonio, Chang, Steven D, Ko, Ara, Specht, Katherine E, Choudhry, Asad, Encalada, Ronald Zerna, Poggio, Juan L, Xing, Hang, Glass, Nina E, Hooker, Robert, Martins, Paulo N, Scott, Erin M, Bankhead, Brittany K, Giorgakis, Emmanouil, Nigh, Joe, Osborn, Tamara, Tay Lasso, Erika L, Beswick, Daniel M, Berndtson, Allison E, Kaups, Krista L, Chen, Lee-lynn, Farrell, Michael S, Boeck, Marissa A, Vaysburg, Dennis M, Kassam, Al-Faraaz, Turner, Kevin M, Dyas, Adam R, Coleman, Julia R, Folsom, Megan, Lam, Christopher M, Kumer, Sean C, Larson, Kelsey, Turner, Scott, Guidry, Christopher, Reddy, Madhuri, Berbel, German, Findley, Austin, Beahm, David, Bur, Andres, Marlor, Derek, Houndschell, Corey, Carver, Shea, Ulrich, Alissa, Bhutiani, Neal, DiChiacchio, Laura, Abdou, Hossam, Napolitano, Lena M, Ghebre, Rahel, Bass, Gary Alan, Kaplan, Lewis J, Martin, Niels D, Duffy, Caoimhe C, Abdelhamid, Sultan S, Daley, Brian J, Roland, Christina L, Dumas, Ryan P, Ban, Vin Shen, Rajesh, Aashish, Davies, Mark G, Purudappa, Prabhudev P, Walters, Camila B, Lin, Nicole, Ruzgar, Nensi M, Ullrich, Sarah J, Trostchansky, Ivan, Bonilla-Cal, Fernando, Castedo, Fabiola, Sobrero, Helena, Acuña, Gastón, Álvarez, Sofía M, Tarigo, Josefina, Carbajal, Ana C, Carbajal, Ana, Reyes, Antonio R, Al-Eryani, Fatima A, Alqousi, Nardeen N, Alattas, Zainab, Al-Saban, Rafat A, Al-Shehari, Mohammed M, ALHammadi, Nawal T, Shream, Sarah A, Al-Naggar, Hamza M, Al-Qalisi, Lina M, Nadeesh, Areej E, Al-Samawi, Hytham H, Bajjah, Hadeel M, AL-Ameri, Saba A, Albably, Jamal F, Ghannam, Rana A, Shamsan, Amatallah H, Meead, Abdullah A, Al- Zubaidi, Riham Q, Zulait, Mohammed A, Najeeb, Halah, Alsayadi, Musaed M, Al-Mashreqi, Seham K, Al-Jomai, Najla A, Alsayadi, Ramzi A, Al-Naggar, Moath M, Almarashi, Hassan A, Musaeed, Hasna M, Al-Raimi, Ibrahim M, Ghanem, Hossam N, Al-Zazay, Karim A, AL-Mahdi, Shehab A, Almontaser, Amatalaleem S, Savopoulos, Vanessa A S, Munthali, James, Kabongo, Kizito M C, Mushiwokufa, Willard, Ngulube, Allan, Ntoto, Crispin, Magama, Praise T, Dzinotyiwei, Daniel, Chivanga, Shelton K, Dube, Ngqabutho S, Sanchez, Ernesto C, Moyo, Assel T, Chengahomwe, Antony, Chinyowa, Simbarashe, Siamuchembu, Maphios, Bondera, Tafadzwa, and Mushawarima, Trust
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- 2022
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17. Assessment of the correlation between environmental variables and the spatial distribution and species structure of testate amoebae (Arcellinida and Euglyphida) in a stratified freshwater lake.
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Sysoev, Vlad V., Seleznev, Dmitry G., Reshetnikov, Fedor Y., and Tikhonenkov, Denis V.
- Subjects
- *
LAKES , *WATERSHEDS , *SPECIES distribution , *ELECTRIC conductivity , *WATER depth - Abstract
Testate amoebae are unicellular organisms that occur worldwide in lacustrine habitats and have been widely used as proxies for palaeoreconstruction and bioindicators of contemporary ecosystems. Our knowledge of the environmental factors determining the spatial distribution of testate amoebae in stratified freshwater lakes remains limited. The objective of this study was to assess the correlations between studied environmental variables and spatial distribution and species structure of testate amoebae communities inhabiting different limnological zones within a single lake basin along the depth gradient. In our study, we used a multistation approach within one waterbody. We collected samples at five transects at five depths in four limnological zones, for a total of 69 samples from 24 sites. Redundancy and k‐means analysis distinguished four groups of samples associated with different environmental conditions. Our results indicate that the distribution of testate amoebae species was correlated with a variety of factors. Along the depth gradient, the distribution of communities was primarily correlated with temperature, electrical conductivity and blue–green algal phycoerythrin. Within the littoral zone, the distribution of species either correlated with the sand content in sediments or was determined by the stochastic beginning of community assembly. In deepwater habitats, the distribution of species was correlated with the dissolved oxygen concentration, pH and concentration of the blue–green algal phycoerythrin. We assume that bottom sediments in single stratified freshwater lakes in shallow and deep water zones represent two distinct biotopes for the formation of communities of testate amoebae, and assessing habitat and community differences in stratified lakes requires a multistation sampling approach. [ABSTRACT FROM AUTHOR]
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- 2024
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18. Clinician perceptions on barriers and facilitators to 1‐year surveillance colonoscopy completion in survivors of colorectal cancer.
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Kwendakwema, C. Natasha, Hopkins, Talor, Bell‐Brown, Ari, Simianu, Vlad V., Shankaran, Veena, and Issaka, Rachel B.
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SOCIAL cognitive theory ,COLORECTAL cancer ,SOCIAL determinants of health ,SURGICAL excision ,MEDICAL personnel - Abstract
Introduction: Colorectal cancer (CRC) is the second leading cause of cancer deaths in the United States. Surveillance colonoscopy is recommended 1‐year after surgical resection for patients with stage I‐III CRC; however, only 18%–61% of CRC survivors complete this test. This study describes clinician‐identified barriers and facilitators to surveillance colonoscopy among CRC survivors. Methods: We conducted semi‐structured interviews with clinicians until thematic saturation was achieved. Interviews were analyzed using the social cognitive theory. Results: Thirteen clinicians were interviewed, and all identified health system‐level barriers to surveillance colonoscopy completion; the most common being fragmented care due to patients receiving care across many health systems. Clinicians also identified social determinants of health barriers (e.g., geographical distance between patients and health systems) to 1‐year surveillance colonoscopy completion. Conclusions: Clinicians identified several potentially modifiable barriers to 1‐year surveillance colonoscopy completion which, if addressed, could improve post‐treatment care and outcomes among stage I‐III CRC survivors. [ABSTRACT FROM AUTHOR]
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- 2024
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19. First records of testate amoebae from the town of Ugolnye Kopi, Chukotka (Russian Arctic)
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Sysoev, Vlad V., primary, Neplyukhina, Alisa A., additional, and Petrovsky, Andrey B., additional
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- 2024
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20. Metalimnion as an ecotone in stratified freshwater lakes: A case study on benthic testate amoebae in Lake Valdayskoe
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Sysoev, Vlad V., primary, Seleznev, Dmitry G., additional, Reshetnikov, Fedor Y., additional, Zakonnov, Viktor V., additional, and Tikhonenkov, Denis V., additional
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- 2024
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21. Evaluating the Regional Uptake of Minimally Invasive Colorectal Surgery: a Report from the Surgical Care Outcomes Assessment Program
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Unruh, Kenley R., Bastawrous, Amir L., Bernier, Greta V., Flum, David R., Kumar, Anjali S., Moonka, Ravi, Thirlby, Richard C., and Simianu, Vlad V.
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- 2021
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22. Where did the patients go? Changes in acute appendicitis presentation and severity of illness during the coronavirus disease 2019 pandemic: A retrospective cohort study
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Neufeld, Miriam Y., Bauerle, Wayne, Eriksson, Evert, Azar, Faris K., Evans, Heather L., Johnson, Meredith, Lawless, Ryan A., Lottenberg, Lawrence, Sanchez, Sabrina E., Simianu, Vlad V., Thomas, Christopher S., and Drake, F. Thurston
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- 2021
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23. Conductivity of solution-processed films of a metal-free chlorophyll derivative: drop casting vs. spin coating
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Koptyaev, Andrey I., Travkin, Vlad V., Sachkov, Yury I., Romanenko, Yuliya V., and Pakhomov, Georgy L.
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- 2021
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24. A Cost-Effectiveness Evaluation of Surgical Approaches to Proctectomy
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Simianu, Vlad V., Curran, Thomas, Gaertner, Wolfgang B., Sklow, Bradford, Kuntz, Karen M., Kwaan, Mary R., Madoff, Robert D., and Jensen, Christine C.
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- 2021
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25. Bis-tetrabenzoporphyrinates of rare earths: Effective template synthesis, optical, electrochemical properties and conductivity in thin films
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Koptyaev, Andrey I., Galanin, Nikolay E., Travkin, Vlad V., and Pakhomov, Georgy L.
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- 2021
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26. Feasibility of injected indocyanine green for ureteral identification during robotic left-sided colorectal resections
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Soriano, Celine R., Cheng, Ron Ron, Corman, John M., Moonka, Ravi, Simianu, Vlad V., and Kaplan, Jennifer A.
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- 2021
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27. Sunlight Bleaching of Subporphyrazine Dye Films
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Vlad V. Travkin, Danila A. Semikov, Pavel A. Stuzhin, Ivan A. Skvortsov, and Georgy L. Pakhomov
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photobleaching ,subphthalocyanines ,absorption spectra ,thin films ,Technology ,Engineering (General). Civil engineering (General) ,TA1-2040 ,Biology (General) ,QH301-705.5 ,Physics ,QC1-999 ,Chemistry ,QD1-999 - Abstract
Stable subphthalocyanine-type dyes with a high electron affinity attract much attention as potential substitutes for traditional fullerenes in molecular electronics devices. One possible way to enhance the acceptor properties of the subphthalocyanine core is by replacing the peripheral benzene fragments (C6H4) with 1,2,5-thiadiazole fragments (C2N2S1). However, the resistance of these materials to light or atmospheric effect remains an open question, which limits their further application in device manufacturing. In this work, we compare vacuum-deposited films of three derivatives, SubPzS3H0 (all peripheral fragments are 1,2,5-thiadiazoles), SubPzS2H4 (two fragments are 1,2,5-thiadiazoles and one fragment is benzene), and SubPcS0H12 (all benzenes, i.e., parent subphthalocyanine). Practically relevant substrates were used for deposition, namely, bare glass, glass/ITO or FTO, and PET/ITO. Photobleaching of films under continuous 1 sun illumination was studied in laboratory air, synthetic air, and ultrapure argon. It is shown that the exclusion of near-UV photons from the incident light spectrum, which corresponds to the absorption of subphthalocyanines in the Soret-band, strongly inhibits degradation. Absorption in the Q-band range initiates soft annealing rather than photobleaching of films. The stability of the films deposited on glass decreases as SubPzS3H0 > SubPzS2H4 > SubPcS0H12 in air, and vice versa in argon. The substrate adds more complexity to this picture. In argon, the ITO coating reduces degradation of all of the compounds equally, in contrast to the glass samples, while in air, the SubPzS3H0 films discolor completely. The latter reaction proceeds due to the indium-containing species migrating from the conductive coating.
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- 2023
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28. Appendiceal Neuroendocrine Tumors: Does Colon Resection Improve Outcomes?
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Crown, Angelena, Simianu, Vlad V., Kennecke, Hagen, Lopez-Aguiar, Alexandra G., Dillhoff, Mary, Beal, Eliza W., Poultsides, George A., Makris, Eleftherios, Idrees, Kamran, Smith, Paula Marincola, Nathan, Hari, Beems, Megan, Abbott, Daniel, Barrett, James, Fields, Ryan C., Davidson, Jesse, Maithel, Shishir K., and Rocha, Flavio G.
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- 2020
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29. Fine topological structure of coherent complex light created by carbon nanocomposites in LC
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Ponevchinsky, Vlad. V., Goncharuk, Andrey I., Minenko, Serguey S., Lisetskii, Longin N., Lebovka, Nikolai I., and Soskin, Marat S.
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Condensed Matter - Soft Condensed Matter - Abstract
Fine complex light structure, optical singularities and electroconductivty of nematic 5CB doped by multi-walled carbon nanotubes (MWCNTs) were investigated. MWCNTs gather spontaneously to system of micro scale clusters with random fractal borders at small enough concentration. They are surrounded by the striped micro scale cladding which creates optical singularities in propagating laser beam. Applied transverse electric field above the Freedericksz initiates homeotropic arrangement of 5CB and the striped inversion walls between nanotubes clusters what diminishes free energy of a composite. Theory of their appearance and properties was built. Simultaneously the striped cladding disappears what can be treated as new mechanism of structure orientation nonlinearity in nonlinear photonics. Polarization singularities (circular C points) were measured firstly. Percolation of clusters enhances strongly electrical conductivity of the system and creates inversion walls even without applied field. Carbon nanotubes composites in LC form bridge between nano dopants and micro/macro system and are promising for applications. Elaborated protocol of singular optics inspection and characterization of LC nanocomposites is promising tool for applications in modern nanosience and technique., Comment: 10 pages, 5 figures
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- 2013
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30. The Effects of Sampling Depth on Benthic Testate Amoeba Assemblages in Freshwater Lakes: A Case Study in Lake Valdayskoe (the East European Plain)
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Vlad V. Sysoev, Andrey N. Tsyganov, Fedor Y. Reshetnikov, and Yuri A. Mazei
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lake ,depth gradient ,littoral ,sublittoral ,bottom slope ,profundal ,Biology (General) ,QH301-705.5 - Abstract
Testate amoebae are widely used as proxies in paleoecological reconstructions of lacustrine environments; however, our knowledge on their distribution along depth gradients are limited. This study investigates the distribution of benthic testate amoebae along a sampling depth gradient (0 to 57 m) and related environmental characteristics in Lake Valdayskoe, Russia. In total, 101 species belonging to twenty-one genera were identified. Four types of testate amoeba assemblages (littoral, sublittoral, bottom slope and profundal) were distinguished that corresponded well to the bottom zones of the lake. The results of redundancy analysis indicated that sampling depth, temperature, pH and bottom inclination significantly explained 40.2% of the total variance in the species composition. Temperature and sampling depth had the largest individual contributions of 19.2 and 7.4% (p < 0.001), respectively. The minimal values of species diversity were observed on the littoral and at the lower boundary of the thermocline. We estimated depth optima and ranges for the species with high occurrences and distinguish stenobathic and eurybathic species. These data might improve the interpretations of paleoecological records of subfossil testate amoeba assemblages in lacustrine surface sediments and serve as basis for the development of a transfer function for reconstruction of lake depths.
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- 2022
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31. Institutional critique : a philosophical investigation of its conditions and possibilities
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Morariu, Vlad V.
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708 ,Art institution ,Artwork ,Co-optation/recuperation of artistic critique ,Deconstruction (of the art institution) ,Inside/outside (of the art institution) ,Institutional critique ,Institutional frames/parergon ,Instituting speech acts/declarations ,Justice/law ,Partner and adversary of the art institution ,The whatness of what art is - Abstract
'Institutional critique' is a term that refers to a range of diverse artistic practices and discourses that emerged at the end of the 1960s and that continue in the present. In spite of their differences, they all share a concern with the institutional conditioning of artists and artworks. Various historicizations of institutional critique (Alberro and Stimson, 2009; Raunig and Ray, 2009; Welchman, 2006) concur that one could distinguish two 'phases': artists of the 1960s and 1970s allegedly investigated the possibilities of an escape towards an 'outside' of the art institution, whereas those of the 1990s analysed the ways in which the artistic subject reproduced the structures of the art institution. Since the beginning of the 2000s various artists and authors have revisited the histories and legacies of institutional critique. This growing interest was triggered by the perceived intensification of a process that began at the end of the 1960s; it refers to the recuperation and neutralization of artistic types of critique by what Boltanski and Chiapello (2005) have called the 'new spirit' of capitalism. In this context, the Austrian philosopher Gerald Raunig and the members of the European Institute for Progressive Cultural Policies have proposed the hypothesis that 'a new phase' of institutional critique was to emerge. However, this proposition was based less on empirical evidence, than on a 'political and theoretical necessity to be found in the logic of institutional critique' (Raunig, 2009, 3). This thesis is a response to this set of circumstances. By asking 'what are the conditions and possibilities of institutional critique?' it investigates the categories of institutional critique's logic. My main argument is that a 'phase change' of institutional critique could and should be understood through the apparatus of Derridean deconstruction. This implies a criticism of the idea that one needs to escape the art institution in order to respond to urgencies stemming from the social, economic, and political realms (Truth Is Concrete Platform, 2012). At the same time, I will also refute the idea that institutional critique is trapped in the art institution (Fraser, 2009a). Institutional critique works on the remainder and rest that necessarily escapes the instituting will and intention of defining and describing in an exhaustive manner the whatness of what (art) is (Boltanski, 2011). I show that between critique and the art institution there is an irreducible relation of symbiosis and cohabitation, and that the deconstructive logic of institutional critique allows it to be both partner and adversary, at the same time, of the art institution.
- Published
- 2014
32. Treatment preferences in diverticulitis are common and rarely change after a clinic visit
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Melio, Anna A., Johnson, Meredith, Kaplan, Jennifer A., Moonka, Ravi, and Simianu, Vlad V.
- Abstract
With the increasing prevalence of diverticulitis, professional guidelines encourage the individualization of treatment. However, the frequency of treatment preferences of both surgeons, and patients, and the resultant impact of that preference on diverticulitis management is underexplored. We reviewed 27 consecutive patient visits of 3 colorectal surgeons at our institution to evaluate factors that drove their treatment, as well as their equipoise for patient randomization into medical or surgical treatments. Using standardized pre- and post-visit questionnaires, we investigated the impact of the clinic visit on treatment recommendations. Our results demonstrate that our surgeons have a practice bias towards complicated disease, and have a preference towards operative management of diverticulitis, in both complicated and uncomplicated disease. This preference was frequently unchanged after clinic visit, which has implications for guiding truly shared decision making, as it continues to be the recommendation.
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- 2024
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33. The Immediate, Hospital-Level Impact of Stay-at-Home Order on Diverticulitis Burden
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Soriano, Celine, Kaplan, Jennifer A., Law, Joanna K., Williams, Barbara L., Blackmore, C. Craig, and Simianu, Vlad V.
- Published
- 2021
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34. Unraveling the adaptive strategies of Mycoplasma hominis through proteogenomic profiling of clinical isolates.
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Pobeguts, Olga V., Galaymina, Maria A., Sikamov, Kirill V., Urazaeva, Diana R., Avshalumov, Alexander S., Mikhailycheva, Maria V., Babenko, Vlad V., Smirnov, Igor P., and Gorbachev, Alexey Yu.
- Subjects
MYCOPLASMA ,UREAPLASMA ,HORIZONTAL gene transfer ,CARBON metabolism ,GENOME size ,DNA methylation - Abstract
Introduction: Mycoplasma hominis (M. hominis) belongs to the class Mollicutes, characterized by a very small genome size, reduction of metabolic pathways, including transcription factors, and the absence of a cell wall. Despite this, they adapt well not only to specific niches within the host organism but can also spread throughout the body, colonizing various organs and tissues. The adaptation mechanisms of M. hominis, as well as their regulatory pathways, are poorly understood. It is known that, when adapting to adverse conditions, Mycoplasmas can undergo phenotypic switches that may persist for several generations. Methods: To investigate the adaptive properties of M. hominis related to survival in the host, we conducted a comparative phenotypic and proteogenomic analysis of eight clinical isolates of M. hominis obtained from patients with urogenital infections and the laboratory strain H-34. Results: We have shown that clinical isolates differ in phenotypic features from the laboratory strain, form biofilms more effectively and show resistance to ofloxacin. The comparative proteogenomic analysis revealed that, unlike the laboratory strain, the clinical isolates possess several features related to stress survival: they switch carbon metabolism, activating the energetically least advantageous pathway of nucleoside utilization, which allows slowing down cellular processes and transitioning to a starvation state; they reconfigure the repertoire of membrane proteins; they have integrative conjugative elements in their genomes, which are key mediators of horizontal gene transfer. The upregulation of the methylating subunit of the restriction-modification (RM) system type I and the additional components of RM systems found in clinical isolates suggest that DNA methylation may play a role in regulating the adaptation mechanisms of M. hominis in the host organism. It has been shown that based on the proteogenomic profile, namely the genome sequence, protein content, composition of the RM systems and additional subunits HsdM, HsdS and HsdR, composition and number of transposable elements, as well as the sequence of the main variable antigen Vaa, we can divide clinical isolates into two phenotypes: typical colonies (TC), which have a high growth rate, and atypical (aTC) mini-colonies, which have a slow growth rate and exhibit properties similar to persisters. Discussion: We believe that the key mechanism of adaptation of M. hominis in the host is phenotypic restructuring, leading to a slowing down cellular processes and the formation of small atypical colonies. This is due to a switch in carbon metabolism and activation the pathway of nucleoside utilization. We hypothesize that DNA methylation may play a role in regulating this switch. [ABSTRACT FROM AUTHOR]
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- 2024
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35. The Application of Biostatistics to Your Surgical Practice
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Simianu, Vlad V., Pedersen, Mark, Petersen, Rebecca P., Kumar, Anjali S., Renton, David B., editor, Nau, Peter, editor, and Gee, Denise W., editor
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- 2017
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36. Modeling of the heliospheric interface: multi-component nature of the heliospheric plasma
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Malama, Yury G., Izmodenov, Vlad V., and Chalov, Sergey V.
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Astrophysics - Abstract
We present a new model of the heliospheric interface - the region of the solar wind interaction with the local interstellar medium. This new model performs a multi-component treatment of charged particles in the heliosphere. All charged particles are divided into several co-moving types. The coldest type, with parameters typical of original solar wind protons, is considered in the framework of fluid approximation. The hot pickup proton components created from interstellar H atoms and heliospheric ENAs by charge exchange, electron impact ionization and photoionization are treated kinetically. The charged components are considered self-consistently with interstellar H atoms, which are described kinetically as well. To solve the kinetic equation for H atoms we use the Monte Carlo method with splitting of trajectories, which allows us 1) to reduce statistical uncertainties allowing correct interpretation of observational data, 2) to separate all H atoms in the heliosphere into several populations depending on the place of their birth and on the type of parent protons., Comment: A&A accepted
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- 2005
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37. Use of Computed Tomography to Determine Perforation in Patients With Acute Appendicitis
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Gaskill, Cameron E., Simianu, Vlad V., Carnell, Jonathan, Hippe, Daniel S., Bhargava, Puneet, Flum, David R., and Davidson, Giana H.
- Published
- 2018
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38. The Cryptosporidium parvum Kinome
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Artz, Jennifer D, Wernimont, Amy K, Allali-Hassani, Abdellah, Zhao, Yong, Amani, Mehrnaz, Lin, Yu-Hui, Senisterra, Guillermo, Wasney, Gregory A, Fedorov, Oleg, King, Oliver, Roos, Annette, Lunin, Vlad V, Qiu, Wei, Finerty, Patrick, Hutchinson, Ashley, Chau, Irene, von Delft, Frank, MacKenzie, Farrell, Lew, Jocelyne, Kozieradzki, Ivona, Vedadi, Masoud, Schapira, Matthieu, Zhang, Chao, Shokat, Kevan, Heightman, Tom, and Hui, Raymond
- Abstract
Abstract Background Hundreds of millions of people are infected with cryptosporidiosis annually, with immunocompromised individuals suffering debilitating symptoms and children in socioeconomically challenged regions at risk of repeated infections. There is currently no effective drug available. In order to facilitate the pursuit of anti-cryptosporidiosis targets and compounds, our study spans the classification of the Cryptosporidium parvum kinome and the structural and biochemical characterization of representatives from the CDPK family and a MAP kinase. Results The C. parvum kinome comprises over 70 members, some of which may be promising drug targets. These C. parvum protein kinases include members in the AGC, Atypical, CaMK, CK1, CMGC, and TKL groups; however, almost 35% could only be classified as OPK (other protein kinases). In addition, about 25% of the kinases identified did not have any known orthologues outside of Cryptosporidium spp. Comparison of specific kinases with their Plasmodium falciparum and Toxoplasma gondii orthologues revealed some distinct characteristics within the C. parvum kinome, including potential targets and opportunities for drug design. Structural and biochemical analysis of 4 representatives of the CaMK group and a MAP kinase confirms features that may be exploited in inhibitor design. Indeed, screening CpCDPK1 against a library of kinase inhibitors yielded a set of the pyrazolopyrimidine derivatives (PP1-derivatives) with IC50 values of < 10 nM. The binding of a PP1-derivative is further described by an inhibitor-bound crystal structure of CpCDPK1. In addition, structural analysis of CpCDPK4 identified an unprecedented Zn-finger within the CDPK kinase domain that may have implications for its regulation. Conclusions Identification and comparison of the C. parvum protein kinases against other parasitic kinases shows how orthologue- and family-based research can be used to facilitate characterization of promising drug targets and the search for new drugs.
- Published
- 2011
39. Draft genomes of Enterococcus faecium strains isolated from human feces before and after eradication therapy against Helicobacter pylori
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Nikita A. Prianichnikov, Maja V. Malakhova, Vlad V. Babenko, Andrei K. Larin, Evgenii I. Olekhnovich, Elizaveta V. Starikova, Dmitry I. Chuvelev, Oksana E. Glushchenko, Andrei E. Samoilov, Alexander I. Manolov, Boris A. Kovarsky, Alexander V. Tyakht, Alexander V. Pavlenko, Elena N. Ilina, and Elena S. Kostryukova
- Subjects
Computer applications to medicine. Medical informatics ,R858-859.7 ,Science (General) ,Q1-390 - Abstract
The abundance of Enterococci in the human intestinal microbiota environment is usually < 0.1% of the total bacterial fraction. The multiple resistance to antibiotics of the opportunistic Enterococcus spp. is alarming for the world medical community because of their high prevalence among clinically significant strains of microorganisms. Enterococci are able to collect different mobile genetic elements and transmit resistance to antibiotics to wide range of Gram-positive and Gram-negative species of microorganisms, including the transmission of vancomycin resistance to methicillin-resistant strains of Staphylococcus aureus. The number of infections caused by antibiotics resistant strains of Enterococcus spp. is increasing. Here we present a draft genomes of Enterococcus faecium strains. These strains were isolated from human feces before and after (1 month) Helicobacter pylori eradication therapy. The samples were subject to whole-genome sequencing using Illumina HiSeq. 2500 platform. The data is available at NCBI https://www.ncbi.nlm.nih.gov/bioproject/PRJNA412824.
- Published
- 2018
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40. Squamous Cell Carcinoma
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Sham, Jonathan G., Simianu, Vlad V., Dong, Zhao Ming, Compton, Nicholas L., Wu, Peter C., Khanna, Ajay K, editor, and Tiwary, Satyendra K, editor
- Published
- 2016
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41. Decomposition of ultrathin LiF cathode underlayer in organic-based devices evidenced by ToF-SIMS depth profiling
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Pakhomov, Georgy L., Drozdov, Mikhail N., Travkin, Vlad V., and Bochkarev, Mikhail N.
- Published
- 2017
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42. The Reliability of a Standardized Reporting System for the Diagnosis of Appendicitis
- Author
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Simianu, Vlad V., Shamitoff, Anna, Hippe, Daniel S., Godwin, Benjamin D., Shriki, Jabi E., Drake, Frederick T., O’Malley, Ryan B., Maximin, Suresh, Bastawrous, Sarah, Moshiri, Mariam, Lee, Jean H., Cuevas, Carlos, Dighe, Manjiri, Flum, David, and Bhargava, Puneet
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- 2017
- Full Text
- View/download PDF
43. Diagnosing Surgical Site Infection Using Wound Photography: A Scenario-Based Study
- Author
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Sanger, Patrick C., Simianu, Vlad V., Gaskill, Cameron E., Armstrong, Cheryl A.L., Hartzler, Andrea L., Lordon, Ross J., Lober, William B., and Evans, Heather L.
- Published
- 2017
- Full Text
- View/download PDF
44. Cost-effectiveness Evaluation of Laparoscopic Versus Robotic Minimally Invasive Colectomy
- Author
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Simianu, Vlad V., Gaertner, Wolfgang B., Kuntz, Karen, Kwaan, Mary R., Lowry, Ann C., Madoff, Robert D., and Jensen, Christine C.
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- 2020
- Full Text
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45. Cost-effectiveness Evaluation of Laparoscopic Versus Robotic Minimally Invasive Colectomy
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Simianu, Vlad V., Gaertner, Wolfgang B., Kuntz, Karen, Kwaan, Mary R., Lowry, Ann C., Madoff, Robert D., and Jensen, Christine C.
- Published
- 2019
- Full Text
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46. A Generalization of Rényi’s Parking Problem
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Andrii B. Ilienko and Vlad V. Fatenko
- Subjects
Rényi’s parking problem ,Mixture of distributions ,Asymptotic behavior ,Functional-integral equation ,Laplace transform ,Tauberian theorems ,Chemical technology ,TP1-1185 ,Science - Abstract
Background. A generalization of the A. Rényi’s stochastic parking model is considered. In our model, the probability distribution of the left end of a parked car is a mixture of a uniform distribution and a degenerated one. This allows distinguishing drivers with different skills. Objective. The aim of the paper is an asymptotic study of the mean number of parked cars \[m_{p}(x) \] when the length of parking space \[x\] increases unboundedly. Methods. A functional-integral equation satisfied by the function \[m_{p}\] is derived. This equation admits an explicit solution in terms of the Laplace transform which allows for applying Tauberian theorems to study the required asymptotics. Results. For the above model it is shown, that \[m_{p}(x)=\lambda_{p}x+o(x)\] as \[x\rightarrow\infty.\] The explicit form of the constant \[\lambda_{p}\] is given by \[\frac{1}{1-p}\int_{0}^{\infty} \mathrm{exp}\left(-2\int_{0}^{S}\frac{e^{\tau}-1}{\tau({e^{\tau}-p})}d\tau\right)ds.\] A similar asymptotic bound is obtained for a wider class of models in which the uniform component of the mixture of distributions is replaced by a more general one. Conclusions. As a generalization of the classical A. Rényi’s random parking model, a new parking model is proposed. In this model the uniform distribution of the parking point is replaced by a mixture of a uniform distribution and a degenerated one. In the new model, a counterpart of the Rényi’s theorem on the asymptotic behavior of the mean number of parked cars is deduced.
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- 2017
- Full Text
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47. Data on gut metagenomes of the patients with Helicobacter pylori infection before and after the antibiotic therapy
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Oksana E. Glushchenko, Andrei E. Samoilov, Evgenii I. Olekhnovich, Boris A. Kovarsky, Alexander V. Tyakht, Alexander V. Pavlenko, Vlad V. Babenko, Andrei K. Larin, Elena S. Kostryukova, Maja V. Malakhova, Elena N. Ilina, Rustem A. Abdulkhakov, Dilyara I. Safina, Tatiana V. Grigoryeva, Sayar R. Abdulkhakov, and Vadim M. Govorun
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Gut microbiota ,Metagenome ,Antibiotic therapy ,Helicobacter pylori ,Computer applications to medicine. Medical informatics ,R858-859.7 ,Science (General) ,Q1-390 - Abstract
Antibiotic therapy can lead to the disruption of gut microbiota community with possible negative outcomes for human health. One of the diseases for which the treatment scheme commonly included antibiotic intake is Helicobacter pylori infection. The changes in taxonomic and functional composition of microbiota in patients can be assessed using “shotgun” metagenomic sequencing. Ten stool samples were collected from 4 patients with Helicobacter pylori infection before and directly after the H. pylori eradication course. Additionally, for two of the subjects, the samples were collected 1 month after the end of the treatment. The samples were subject to “shotgun” (whole-genome) metagenomic sequencing using Illumina HiSeq platform. The reads are deposited in the ENA (project ID: PRJEB18265).
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- 2017
- Full Text
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48. Minimally-invasive approach to emergent colorectal surgery in aging adults: A report from the Surgical Care Outcomes Assessment Program
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Alex Charboneau, Timothy Feldmann, Shalini Kanneganti, Jennifer A. Kaplan, Ravi Moonka, Arthur Sillah, Richard C. Thirlby, and Vlad V. Simianu
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Aging ,Outcome Assessment, Health Care ,Humans ,Minimally Invasive Surgical Procedures ,Surgery ,General Medicine ,Length of Stay ,Colorectal Surgery ,Aged ,Retrospective Studies - Abstract
Despite known benefits of minimally invasive surgery(MIS) in elective settings, MIS use in emergency colorectal surgery(CRS) is limited. Older adults are more likely to require emergent CRS, and MIS is used less frequently with increasing age.A retrospective cohort was constructed of emergent CRS cases performed between 2011 and 2019. Discharge(DC) disposition, adverse events, and length of stay(LOS) between MIS and open surgery were compared and stratified by age. Adjustment was made for selected confounders using inverse probability weighting.Of 6913 emergent CRS cases across 50 hospitals, 1616(23%) were approached MIS. MIS cases were more likely [OR(95%CI)] to DC home [65yo:1.7(1.3,2.2); 65-74:1.5(1.1,1.9); 75+:1.2(0.9,1.5)] and have fewer adverse events [65yo:0.6(0.5,0.8); 65-74:0.7(0.5,0.9); 75+:0.7(0.5,0.9)]. LOS was shorter [Mean difference in days(95%CI)] [65yo: 2.2(-2.9,-1.4); 65-74: 0.9(-2.7,1.0); 75+: 0.7(-1.7,0.2)].MIS in emergent CRS is associated with increased DC to home, fewer adverse events, and shorter LOS. Benefits persisted with age after adjustment, suggesting an opportunity for improved MIS delivery in older adults.
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- 2022
49. AB0674 PRIMARY SJOGREN SYNDROME WITH ANTICENTROMERE ANTIBODIES - A CLINICALLY DISTINCT PHENOTYPE OR AN OVERLAP SYNDROME?
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Cristina, N., primary, Nicoara, D., additional, Groseanu, L., additional, Opris Belinski, D., additional, Bojinca, V., additional, Predeteanu, D., additional, Berghea, F., additional, Vlad, V., additional, Saulescu, I., additional, Daia-Iliescu, S., additional, Mazilu, D., additional, Borangiu, A., additional, Cobilinschi, C., additional, Negru, M. M., additional, Constantinescu, C. L., additional, Mardale, D., additional, Duna, M., additional, Abobului, M., additional, Ionescu, R., additional, and Balanescu, A., additional
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- 2023
- Full Text
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50. AB1385 SUBOPTIMAL IDENTIFICATION AND MANAGEMENT OF NON-NOCICEPTIVE TYPES OF PAIN IN PATIENTS WITH RHEUMATOID ARTHRITIS REGARDLESS THE ACTIVITY STATUS
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Berghea, F., primary, Bratu, R., additional, Cristina, N., additional, Spoeala, A. M., additional, Dogaru, T., additional, Dinoiu, A., additional, Mihailescu, A., additional, Boromiz, C., additional, Juganaru, E., additional, Constantinescu, A., additional, Zanfir, V., additional, Mardale, D., additional, Doran, A., additional, Duna, M., additional, Vlad, V., additional, Abobului, M., additional, Negru, M. M., additional, Saulescu, I., additional, Cobilinschi, C., additional, Constantinescu, C., additional, Mazilu, D., additional, Borangiu, A., additional, Daia-Iliescu, S., additional, Groseanu, L., additional, Opris-Belinski, D., additional, Predeteanu, D., additional, Bojinca, V., additional, Zaharia, D., additional, Trandafir, A., additional, and Balanescu, A., additional
- Published
- 2023
- Full Text
- View/download PDF
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