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3. Percutaneous coronary interventions for aneurysmatic right coronary artery in acute coronary syndrome: RIGHTMARE registry outcomes

Author

Piedimonte, Giulio, Cerrato, Enrico, Rolfo, Cristina, Nunez Gil, Ivan J., Azzalini, Lorenzo, Mangione, Riccardo, Maiellaro, Francesco, Boi, Alberto, Riganelli, Donovan, Sardone, Andrea, Bruno, Francesco, Scudiero, Fernando, Vizzari, Giampiero, Carciotto, Gabriele, Calderone, Dario, Borgi, Marco, Cancro, Francesco Paolo, Sanchez, Ivan, Leoncini, Massimo, Sagazio, Emanuele, Colombo, Francesco, Rosso, Gabriele, Chechi, Tania, Zecchino, Simone, Pavani, Marco, Franzè, Alfonso, Zanda, Greca, Bosco, Manuel, Hernandez, Jose Maria De La Torre, Micari, Antonio, Galasso, Gennaro, Versaci, Francesco, Tamburino, Corrado, Patti, Giuseppe, La Manna, Alessio, Tomassini, Francesco, and Varbella, Ferdinando

Published
2024
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6. Performance of the Mammoth Balloon Catheter in Patients with Severe Aortic Valve Stenosis Undergoing Percutaneous Treatment.

Author

Moscardelli, Silvia, Caminiti, Rodolfo, Montonati, Carolina, Ceresa, Fabrizio, De Blasio, Giuseppe, Vizzari, Giampiero, Pellegrini, Dario, Pellicano, Mariano, Guagliumi, Giulio, Patanè, Francesco, Tespili, Maurizio, Micari, Antonio, and Ielasi, Alfonso

Subjects
PERCUTANEOUS balloon valvuloplasty, AORTIC stenosis, AORTIC valve transplantation, HOSPITAL rounds, MAMMOTHS
Abstract

Background: Balloon aortic valvuloplasty (BAV) is currently used as pre-treatment for patients undergoing trans-catheter aortic valve replacement (TAVR) as well as a stand-alone option for subjects with significant contraindications to TAVR. Mammoth is a newly available non-compliant balloon catheter (BC) included in the balloon-expandable Myval THV system (Meril Life Sciences Pvt. Ltd., India). As limited data on the performance of this BC are available, we here report the results following its use for BAV as pre-dilatation during TAVR or as a stand-alone procedure. Methods: A retrospective, single-center cohort analysis was performed on patients with severe aortic valve stenosis (AS) treated with the Mammoth BC at IRCCS Ospedale Galeazzi Sant'Ambrogio, Milan, Italy. The primary endpoint was technical success defined as successful Mammoth BC advancement across the AS followed by its full and homogeneous inflation without major complications such as aortic root/left ventricular outflow tract injury and/or stroke. Results: A total of 121 patients were treated by BAV with Mammoth BC during the study period. Among these, 105 patients underwent BAV pre-dilatation before TAVR while 16 patients underwent a stand-alone BAV procedure. Mammoth BC was delivered and successfully inflated at the target site in all of the 121 cases without BC-related complications (100% technical success). However, in the BAV "stand-alone group", three patients required two different balloon sizes while in nine patients multiple rounds (two to three) of balloon inflation were needed to significantly lower the transvalvular gradient. No cases of aortic root injury or massive aortic regurgitation due to Mammoth BC-related aortic leaflet injury were reported while one major stroke occurred late after TAVR. No intra-procedural deaths occurred nor bleeding (BARC 3-4) or major vascular complication. Conclusions: Mammoth BC use in patients with severe AS proved safe and effective, either before TAVR or as a stand-alone procedure, expanding the range of available tools for structural operators. [ABSTRACT FROM AUTHOR]

Published
2024
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7. Veno-arterial extracorporeal membrane oxygenation supported transcatheter aortic valve implantation in a high-risk COVID-19 patient: a comprehensive case report.

Author

Vizzari, Giampiero, Ferrari, Tommaso De, Costa, Francesco, Mancini, Nastasia, Franzino, Marco, Ceresa, Fabrizio, Patanè, Francesco, and Micari, Antonio

Subjects
HEART valve prosthesis implantation, EXTRACORPOREAL membrane oxygenation, HEART failure, ARTIFICIAL blood circulation, COVID-19, PATIENT selection
Abstract

Background The sudden onset of heart failure in high-risk transcatheter aortic valve implantation (TAVI) candidates poses significant challenges, necessitating meticulous planning and consideration of mechanical circulatory support options. Nevertheless, existing data on the efficacy and safety of mechanical circulatory support in this context are limited, along with criteria for patient selection. Case summary An 87-year-old patient, with severe low-flow low-gradient aortic stenosis, presented with acute heart failure and concurrent COVID-19 pneumonia. Despite initial conservative management, her clinical condition deteriorated, requiring inotropic support. The decision was made to perform a rescue TAVI procedure with veno-arterial extracorporeal membrane oxygenation (ECMO) support. The patient underwent successful TAVI while managing complications, including cardiac arrest, with haemodynamic support from veno-arterial ECMO. Post-procedure, the patient showed improved cardiac function and was discharged in stable condition. Discussion This case underscores the significance of strategic patient selection, proactive haemodynamic management, and the judicious use of veno-arterial ECMO in high-risk TAVI, particularly in complex scenarios involving acute heart failure and respiratory insufficiency, exacerbated by COVID-19. It highlights the challenges and critical decision points in TAVI planning, emphasizing the need for further research and standardized guidelines to refine indications for prophylactic mechanical circulatory support in TAVI procedures. [ABSTRACT FROM AUTHOR]

Published
2024
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8. Antithrombotic Therapy in Patients Undergoing Transcatheter Aortic Valve Implantation

Author

Pallante, Francesco, primary, Costa, Francesco, additional, Garcia Ruiz, Victoria, additional, Vizzari, Giampiero, additional, Iannello, Pietro, additional, Teresi, Lucio, additional, Carciotto, Gabriele, additional, Lo Giudice, Stefania, additional, Iuvara, Giustina, additional, Laterra, Giulia, additional, Regueiro, Ander, additional, Giustino, Gennaro, additional, Alonso Briales, Juan Horacio, additional, Hernandez, Jose Maria, additional, Barbanti, Marco, additional, Micari, Antonio, additional, and Patanè, Francesco, additional

Published
2024
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9. Acute and long-term results of percutaneous coronary intervention of bifurcation lesions with the dedicated Bioss Lim C stent: the Italian BIfurcation Observational Spontaneous Study (IBIOSS)

Author

BRIGUORI, Carlo, primary, CAPODANNO, Davide, additional, CONTARINI, Marco, additional, DONAHUE, Michael E., additional, EVOLA, Salvatore, additional, GARRO, Nadia, additional, GRECO, Francesco, additional, LA MANNA, Alessio, additional, MURÈ, Paola, additional, NICOSIA, Antonino, additional, MIGLIORE, Giuseppe, additional, SACCHETTA, Giorgio, additional, SIGNORE, Nicola, additional, TAMBURINO, Corrado, additional, VIZZARI, Giampiero, additional, and BIONDI-ZOCCAI, Giuseppe, additional

Published
2024
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11. Antithrombotic Therapy in Patients Undergoing Transcatheter Aortic Valve Implantation.

Author

Pallante, Francesco, Costa, Francesco, Garcia Ruiz, Victoria, Vizzari, Giampiero, Iannello, Pietro, Teresi, Lucio, Carciotto, Gabriele, Lo Giudice, Stefania, Iuvara, Giustina, Laterra, Giulia, Regueiro, Ander, Giustino, Gennaro, Alonso Briales, Juan Horacio, Hernandez, Jose Maria, Barbanti, Marco, Micari, Antonio, and Patanè, Francesco

Subjects
FIBRINOLYTIC agents, AORTIC stenosis
Abstract

Transcatheter aortic valve implantation (TAVI) now represents the mainstay of treatment for severe aortic stenosis. Owing to its exceptional procedural efficacy and safety, TAVI has been extended to include patients at lower surgical risk, thus now encompassing a diverse patient population receiving this treatment. Yet, long-term outcomes also depend on optimal medical therapy for secondary vascular prevention, with antithrombotic therapy serving as the cornerstone. Leveraging data from multiple randomized controlled trials, the current guidelines generally recommend single antithrombotic therapy, with either single antiplatelet therapy (SAPT) or oral anticoagulation (OAC) alone in those patients without or with atrial fibrillation, respectively. Yet, individualization of this pattern, as well as specific case uses, may be needed based on individual patient characteristics and concurrent procedures. This review aims to discuss the evidence supporting antithrombotic treatments in patients treated with TAVI, indications for a standardized treatment, as well as specific considerations for an individualized approach to treatment. [ABSTRACT FROM AUTHOR]

Published
2024
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12. Percutaneous Coronary Intervention before or after Transcatheter Aortic Valve Replacement: A Systematic Review and Meta-Analysis Involving 1531 Patients.

Author

Caminiti, Rodolfo, Ielasi, Alfonso, Vetta, Giampaolo, Parlavecchio, Antonio, Della Rocca, Domenico Giovanni, Pellegrini, Dario, Pellicano, Mariano, Montonati, Carolina, Mancini, Nastasia, Carciotto, Gabriele, Ajello, Manuela, Iuvara, Giustina, Costa, Francesco, Laterra, Giulia, Barbanti, Marco, Ceresa, Fabrizio, Patanè, Francesco, Micari, Antonio, and Vizzari, Giampiero

Subjects
HEART valve prosthesis implantation, PERCUTANEOUS coronary intervention, MYOCARDIAL infarction, TREATMENT effectiveness
Abstract

Background: The optimal timing to perform percutaneous coronary interventions (PCIs) in patients undergoing transcatheter aortic valve replacement (TAVR) is not well established. In this meta-analysis, we aimed to compare the outcomes of patients undergoing PCI before versus after TAVR. Methods: A comprehensive literature search was performed including Medline, Embase, and Cochrane electronic databases up to 5 April 2024 for studies that compared PCI before and after TAVR reporting at least one clinical outcome of interest (PROSPERO ID: CRD42023470417). The analyzed outcomes were mortality, stroke, and myocardial infarction (MI) at follow-up. Results: A total of 3 studies involving 1531 patients (pre-TAVR PCI n = 1240; post-TAVR PCI n = 291) were included in this meta-analysis following our inclusion criteria. Mortality was higher in the pre-TAVR PCI group (OR: 2.48; 95% CI: 1.19–5.20; p = 0.02). No differences were found between PCI before and after TAVR for the risk of stroke (OR: 3.58; 95% CI: 0.70–18.15; p = 0.12) and MI (OR: 0.66; 95% CI: 0.30–1.42; p = 0.29). Conclusions: This meta-analysis showed in patients with stable CAD undergoing TAVR that PCI after TAVR is associated with lower mortality compared with PCI before TAVR. [ABSTRACT FROM AUTHOR]

Published
2024
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14. Ruling Out Left Main Stem Stenosis by Clinical and Stress ECG Variables: The MASTER Case-Control Multicenter Study

Author

De Carlo, Marco, primary, Fornili, Marco, additional, Baglietto, Laura, additional, Berti, Sergio, additional, Carmisciano, Luca, additional, De Caterina, Alberto Ranieri, additional, Fabozzo, Simona, additional, Lanza, Gaetano Antonio, additional, Mancini, Nastasia, additional, Massacesi, Cristiano, additional, Neglia, Danilo, additional, Pastore, Maria Concetta, additional, Patti, Giuseppe, additional, Tremamunno, Saverio, additional, Vizzari, Giampiero, additional, Weintraub, William S., additional, Temporelli, Pier Luigi, additional, and De Caterina, Raffaele, additional

Published
2024
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15. Drug-Coated Balloon Versus Drug-Eluting Stent for Treating De Novo Large Vessel Coronary Artery Disease: A Systematic Review and Meta-Analysis of 13 Studies Involving 2,888 Patients

Author

Caminiti, Rodolfo, primary, Vizzari, Giampiero, additional, Ielasi, Alfonso, additional, Vetta, Giampaolo, additional, Parlavecchio, Antonio, additional, Della Rocca, Domenico, additional, Pellicano, Mariano, additional, Pellegrini, Dario, additional, Montonati, Carolina, additional, Tespili, Maurizio, additional, and Micari, Antonio, additional

Published
2023
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21. Spectral CT Imaging of Prosthetic Valve Embolization after Transcatheter Aortic Valve Implantation

Author

D’Angelo, Tommaso, Vizzari, Giampiero, Lanzafame, Ludovica R.M., Pergolizzi, Federica, Mazziotti, Silvio, Gaeta, Michele, Costa, Francesco, Di Bella, Gianluca, Vogl, Thomas J., Booz, Christian, Micari, Antonio, Blandino, Alfredo, D’Angelo, Tommaso, Vizzari, Giampiero, Lanzafame, Ludovica R.M., Pergolizzi, Federica, Mazziotti, Silvio, Gaeta, Michele, Costa, Francesco, Di Bella, Gianluca, Vogl, Thomas J., Booz, Christian, Micari, Antonio, and Blandino, Alfredo

Abstract

Transcatheter heart valve (THV) embolization is a rare complication of transcatheter aortic valve implantation (TAVI) generally caused by malpositioning, sizing inaccuracies and pacing failures. The consequences are related to the site of embolization, ranging from a silent clinical picture when the device is stably anchored in the descending aorta to potentially fatal outcomes (e.g., obstruction of flow to vital organs, aortic dissection, thrombosis, etc.). Here, we present the case of a 65-year-old severely obese woman affected by severe aortic valve stenosis who underwent TAVI complicated by embolization of the device. The patient underwent spectral CT angiography that allowed for improved image quality by means of virtual monoenergetic reconstructions, permitting optimal pre-procedural planning. She was successfully re-treated with implantation of a second prosthetic valve a few weeks later.

Published
2023

22. Spectral CT Imaging of Prosthetic Valve Embolization after Transcatheter Aortic Valve Implantation

Author

D’Angelo, Tommaso, primary, Vizzari, Giampiero, additional, Lanzafame, Ludovica R. M., additional, Pergolizzi, Federica, additional, Mazziotti, Silvio, additional, Gaeta, Michele, additional, Costa, Francesco, additional, Di Bella, Gianluca, additional, Vogl, Thomas J., additional, Booz, Christian, additional, Micari, Antonio, additional, and Blandino, Alfredo, additional

Published
2023
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25. 778 IN-STENT USE OF INTRAVASCULAR LITHOTRIPSY IN THE TREATMENT OF STENT UNDEREXPANSION: A SYSTEMATIC REVIEW AND METAREGRESSION

Author

Caminiti, Rodolfo, primary, Vetta, Giampaolo, additional, Parlavecchio, Antonio, additional, Magnocavallo, Michele, additional, Della Rocca, Domenico Giovanni, additional, Cerrato, Enrico, additional, Saporito, Francesco, additional, Andò, Giuseppe, additional, Carerj, Scipione, additional, Di Bella, Gianluca, additional, Micari, Antonio, additional, and Vizzari, Giampiero, additional

Published
2022
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27. 773 CONTRAST-ENHANCED EXCIMER LASER CORONARY ANGIOPLASTY IN THE TREATMENT OF HEAVILY CALCIFIED LESIONS: A STEPWISE APPROACH

Author

Caminiti, Rodolfo, primary, Vetta, Giampaolo, additional, Parlavecchio, Antonio, additional, Mazzone, Paolo, additional, Giacchi, Giuseppe, additional, Sacchetta, Giorgio, additional, Della Rocca, Domenico Giovanni, additional, Magnocavallo, Michele, additional, Virga, Vittorio, additional, Costa, Francesco, additional, Di Bella, Gianluca, additional, Carerj, Scipione, additional, Contarini, Marco, additional, Vizzari, Giampiero, additional, and Micari, Antonio, additional

Published
2022
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32. Intravascular Lithotripsy for the Treatment of Underexpanded Stents: A Systematic Review and Meta-Regression Including 354 Patients from 13 Studies

Author

Caminiti, Rodolfo, primary, Vetta, Giampaolo, additional, Vizzari, Giampiero, additional, Parlavecchio, Antonio, additional, Magnocavallo, Michele, additional, Della Rocca, Domenico Giovanni, additional, Cerrato, Enrico, additional, Carerj, Scipione, additional, Di Bella, Gianluca, additional, and Micari, Antonio, additional

Published
2022
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33. 704 Stress echocardiography: myocardial work ‘works’

Author

Cusma, Maurizio, primary, Caminiti, Rodolfo, additional, Parlavecchio, Antonio, additional, Vizzari, Giampiero, additional, Fichera, Nunzio, additional, Mancini, Nastasia, additional, De Sarro, Rosalba, additional, Trio, Olimpia, additional, Manganaro, Roberta, additional, Carerj, Scipione, additional, Di Bella, Gianluca, additional, Micari, Antonio, additional, and Zito, Concetta, additional

Published
2021
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34. 686 Coronary lesion distribution in young patient presenting with acute coronary syndrome

Author

Franzino, Marco, primary, Pistelli, Lorenzo, additional, Parisi, Francesca, additional, De Santis, Giulia Azzurra, additional, Nicolò, Claudio, additional, Andò, Giuseppe, additional, Virga, Vittorio, additional, Vizzari, Giampiero, additional, Saporito, Francesco, additional, Carerj, Scipione, additional, Di Bella, Gianluca, additional, Micari, Antonio, additional, and Costa, Francesco, additional

Published
2021
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39. Spectral CT Imaging of Prosthetic Valve Embolization after Transcatheter Aortic Valve Implantation.

Author

D'Angelo, Tommaso, Vizzari, Giampiero, Lanzafame, Ludovica R. M., Pergolizzi, Federica, Mazziotti, Silvio, Gaeta, Michele, Costa, Francesco, Di Bella, Gianluca, Vogl, Thomas J., Booz, Christian, Micari, Antonio, and Blandino, Alfredo

Subjects
*HEART valve prosthesis implantation, *COMPUTED tomography, *SPECTRAL imaging, *AORTIC stenosis, *AORTIC valve insufficiency, *OBESITY in women
Abstract

Transcatheter heart valve (THV) embolization is a rare complication of transcatheter aortic valve implantation (TAVI) generally caused by malpositioning, sizing inaccuracies and pacing failures. The consequences are related to the site of embolization, ranging from a silent clinical picture when the device is stably anchored in the descending aorta to potentially fatal outcomes (e.g., obstruction of flow to vital organs, aortic dissection, thrombosis, etc.). Here, we present the case of a 65-year-old severely obese woman affected by severe aortic valve stenosis who underwent TAVI complicated by embolization of the device. The patient underwent spectral CT angiography that allowed for improved image quality by means of virtual monoenergetic reconstructions, permitting optimal pre-procedural planning. She was successfully re-treated with implantation of a second prosthetic valve a few weeks later. [ABSTRACT FROM AUTHOR]

Published
2023
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40. TCT-238 Real-World Experience With the New Watchman FLX Device: Data From Two High-Volume Sicilian Centers: The FLX-IEST Registry

Author

Vizzari, Giampiero, primary, Contarini, Marco, additional, Mazzone, Paolo, additional, Sardone, Andrea, additional, Laterra, Giulia, additional, Frazzetto, Marco Giuseppe, additional, Sanfilippo, Maria, additional, Sacchetta, Giorgio, additional, Tamburino, Corrado, additional, Micari, Antonio, additional, and Grasso, Carmelo, additional

Published
2021
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43. Patent foramen ovale: anatomical complexity and long-tunnel morphology related issues

Author

Vizzari, Giampiero, Pizzino, Fausto, Zwicke, Dianne, Tajik, A Jamil, Carerj, Scipione, Di Bella, Gianluca, Micari, Antonio, Khandheria, Bijoy K, and Zito, Concetta

Subjects
cryptogenic stroke, tunnel PFO, Review Article, percutaneous PFO closure, complex PFO, Patent foramen ovale
Abstract

Patent foramen ovale (PFO) is present in about one-quarter of the population and should be considered an anatomical variant rather than a malformation. The association of PFO with cryptogenic stroke, migraine, peripheral embolism and other pathologies is still controversial. The evaluation of anatomical complexity, and particularly the long-tunnel morphology, is crucial for the assessment of the risk profile and for a targeted therapeutic management. Long-tunnel PFOs seem to be more prone to clot formation and complications related to percutaneous closure procedures. Echocardiography is the most useful method to investigate anatomical complexity, confirm and reinforce the indication to treatment, select the appropriate device and guide the PFO closure towards a successful procedure.

Published
2021

46. P2Y12 inhibitors monotherapy after short course of dual antiplatelet therapy in patients undergoing percutaneous coronary intervention: a meta-analysis of randomized clinical trials including 29 089 patients

Author

Bianco, Matteo, primary, Careggio, Alessandro, additional, Destefanis, Paola, additional, Luciano, Alessia, additional, Perrelli, Maria Giulia, additional, Quadri, Giorgio, additional, Rossini, Roberta, additional, Campo, Gianluca, additional, Vizzari, Giampiero, additional, D’Ascenzo, Fabrizio, additional, Anselmino, Matteo, additional, Biondi-Zoccai, Giuseppe, additional, Ibáñez, Borja, additional, Montagna, Laura, additional, Varbella, Ferdinando, additional, and Cerrato, Enrico, additional

Published
2020
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47. A broken promise

Author

Versaci, Francesco, primary, Vizzari, Giampiero, additional, Prati, Francesco, additional, and Biondi-Zoccai, Giuseppe, additional

Published
2020
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