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1. Lung Infection by Human Bocavirus Induces the Release of Profibrotic Mediator Cytokines In Vivo and In Vitro.

Author

Soumaya Khalfaoui, Vivien Eichhorn, Christian Karagiannidis, Inga Bayh, Michael Brockmann, Monika Pieper, Wolfram Windisch, Oliver Schildgen, and Verena Schildgen

Subjects
Medicine, Science
Abstract

Human Bocavirus subtype 1 (HBoV1) is associated with respiratory diseases and may contribute to chronic lung diseases by persisting in the infected host. Here the question was addressed if HBoV infections could contribute to fibrogenesis processes as suggested by previously published clinical observations. Cytokine profiles induced by HBoV infection in CuFi-8 air-liquid interphase cell cultures and in bronchoalveolar lavage fluid (BALF) of 20 HBoV-positive and 12 HBoV-negative patients were analysed by semi-quantitative Western spot blot analyses. Although lots of cytokines were regulated independently of HBoV status, several cytokines associated with lung fibrosis and tumour development, e.g., EGF, VEGF, TARC (CCL17), TNF-α, TNF-β, TIMP-1, were clearly upregulated in the HBoV-positive cohort. These findings suggest that the development of lung fibrosis might be triggered by HBoV induced cytokine expression.

Published
2016
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2. Lung Infection by Human Bocavirus Induces the Release of Profibrotic Mediator Cytokines In Vivo and In Vitro

Author

Oliver Schildgen, Inga Bayh, Monika Pieper, Christian Karagiannidis, Michael Brockmann, Vivien Eichhorn, Soumaya Khalfaoui, Verena Schildgen, and Wolfram Windisch

Subjects
0301 basic medicine, Viral Diseases, Pulmonology, Physiology, Pulmonary Fibrosis, medicine.medical_treatment, lcsh:Medicine, Pathology and Laboratory Medicine, 0302 clinical medicine, Fibrosis, Immune Physiology, Human bocavirus, Pulmonary fibrosis, Medicine and Health Sciences, CCL17, lcsh:Science, Immune Response, Lung, Cells, Cultured, Innate Immune System, Multidisciplinary, medicine.diagnostic_test, Coinfection, Human Bocavirus Infection, Middle Aged, respiratory system, Up-Regulation, Infectious Diseases, Cytokine, medicine.anatomical_structure, Medical Microbiology, Viral Pathogens, 030220 oncology & carcinogenesis, Viruses, Cytokines, Biological Cultures, Pathogens, Bronchoalveolar Lavage Fluid, Research Article, Adult, Immunology, Pneumonia, Viral, Biology, Research and Analysis Methods, Microbiology, Bocavirus, Parvoviridae Infections, 03 medical and health sciences, Immune system, Parvoviruses, medicine, Humans, Animal Models of Disease, Microbial Pathogens, Aged, Retrospective Studies, lcsh:R, Organisms, Biology and Life Sciences, Molecular Development, Cell Cultures, medicine.disease, biology.organism_classification, respiratory tract diseases, Animal Models of Infection, HEK293 Cells, 030104 developmental biology, Bronchoalveolar lavage, Immune System, Alveolar Epithelial Cells, Respiratory Infections, Chronic Disease, Animal Studies, lcsh:Q, DNA viruses, Lung Diseases, Interstitial, Developmental Biology
Abstract

Human Bocavirus subtype 1 (HBoV1) is associated with respiratory diseases and may contribute to chronic lung diseases by persisting in the infected host. Here the question was addressed if HBoV infections could contribute to fibrogenesis processes as suggested by previously published clinical observations. Cytokine profiles induced by HBoV infection in CuFi-8 air-liquid interphase cell cultures and in bronchoalveolar lavage fluid (BALF) of 20 HBoV-positive and 12 HBoV-negative patients were analysed by semi-quantitative Western spot blot analyses. Although lots of cytokines were regulated independently of HBoV status, several cytokines associated with lung fibrosis and tumour development, e.g., EGF, VEGF, TARC (CCL17), TNF-α, TNF-β, TIMP-1, were clearly upregulated in the HBoV-positive cohort. These findings suggest that the development of lung fibrosis might be triggered by HBoV induced cytokine expression.

Published
2016

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