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2. Terahertz photodetection in scalable single-layer-graphene and hexagonal boron nitride heterostructures

Author

Asgari, M., Viti, L., Balci, O., Shinde, S. M., Zhang, J., Ramezani, H., Sharma, S., Meersha, A., Menichetti, G., McAleese, C., Conran, B., Wang, X., Tomadin, A., Ferrari, A. C., and Vitiello, M. S.

Subjects
Condensed Matter - Mesoscale and Nanoscale Physics, Physics - Optics
Abstract

The unique optoelectronic properties of single layer graphene (SLG) are ideal for the development of photonic devices across a broad range of frequencies, from X-rays to microwaves. In the terahertz (THz) range (0.1-10 THz frequency) this has led to the development of optical modulators, non-linear sources, and photodetectors, with state-of-the-art performances. A key challenge is the integration of SLG-based active elements with pre-existing technological platforms in a scalable way, while maintaining performance level unperturbed. Here, we report on the development of room temperature THz detection in large-area SLG, grown by chemical vapor deposition (CVD), integrated in antenna-coupled field effect transistors. We selectively activate the photo-thermoelectric detection dynamics, and we employ different dielectric configurations on SLG on Al2O3 with and without large-area CVD hBN capping to investigate their effect on SLG thermoelectric properties underpinning photodetection. With these scalable architectures, response times ~5ns and noise equivalent powers ~1nWHz-1/2 are achieved under zero-bias operation. This shows the feasibility of scalable, large-area, layered materials heterostructures for THz detection., Comment: 15 pages, 4 Figures. The following article has been accepted by Applied Physics Letters. After it is published, it will be found at the link https://doi.org/10.1063/5.0097726

Published
2022
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3. Terahertz frequency combs exploiting an on-chip solution processed graphene-quantum cascade laser coupled-cavity architecture

Author

Mezzapesa, F. P., Garrasi, K., Schmidt, J., Salemi, L., Pistore, V., Li, L., Davies, A. G., Linfield, E. H., Riesch, M., Jirauschek, C., Carey, T., Torrisi, F., Ferrari, A. C., and Vitiello, M. S.

Subjects
Physics - Optics, Condensed Matter - Mesoscale and Nanoscale Physics, Physics - Applied Physics
Abstract

The ability to engineer quantum-cascade-lasers (QCLs) with ultrabroad gain spectra and with a full compensation of the group velocity dispersion, at Terahertz (THz) frequencies, is a fundamental need for devising monolithic and miniaturized optical frequency-comb-synthesizers (FCS) in the far-infrared. In a THz QCL four-wave mixing, driven by the intrinsic third-order susceptibility of the intersubband gain medium, self-lock the optical modes in phase, allowing stable comb operation, albeit over a restricted dynamic range (~ 20% of the laser operational range). Here, we engineer miniaturized THz FCSs comprising a heterogeneous THz QCL integrated with a tightly-coupled on-chip solution-processed graphene saturable-absorber reflector that preserves phase-coherence between lasing modes even when four-wave mixing no longer provides dispersion compensation. This enables a high-power (8 mW) FCS with over 90 optical modes to be demonstrated, over more than 55% of the laser operational range. Furthermore, stable injection-locking is showed, paving the way to impact a number of key applications, including high-precision tuneable broadband-spectroscopy and quantum-metrology., Comment: 31 pages, 11 figures, to be published in ACS Photonics

Published
2020

4. THz detection with epitaxial graphene field effect transistors on silicon carbide

Author

Bianco, F., Perenzoni, D., Convertino, D., De Bonis, S. L., Spirito, D., Vitiello, M. S., Coletti, C., Perenzoni, M., and Tredicucci, A.

Subjects
Physics - Applied Physics, Condensed Matter - Mesoscale and Nanoscale Physics
Abstract

We report on room temperature THz detection by means of antenna-coupled field effect transistors fabricated by using epitaxial graphene grown on silicon carbide substrate. Two independent detection mechanisms are found: plasma wave assisted-detection and thermoelectric effect, which is ascribed to the presence of junctions along the FET channel. The superposition of the calculated functional dependence of both the plasmonic and thermoelectric photovoltages on the gate bias qualitatively well reproduces the measured photovoltages. Additionally, the sign reversal of the measured photovoltage demonstrates the stronger contribution of the plasmonic detection compared to the thermoelectric mechanism. Although responsivity improvement is necessary, these results demonstrate that plasmonic detectors fabricated by epitaxial graphene on silicon carbide are potential candidates for fast large area imaging of macroscopic samples.

Published
2018
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5. The role of surface chemical reactivity in the stability of electronic nanodevices based on two-dimensional materials 'beyond graphene' and topological insulators

Author

Politano, A., Vitiello, M. S., Viti, L., Boukhvalov, D. W., and Chiarello, G.

Subjects
Condensed Matter - Materials Science, Condensed Matter - Mesoscale and Nanoscale Physics
Abstract

Here, we examine the influence of surface chemical reactivity toward ambient gases on the performance of nanodevices based on two-dimensional materials "beyond graphene" and novel topological phases of matter. While surface oxidation in ambient conditions was observed for silicene and phosphorene with subsequent reduction of the mobility of charge carriers, nanodevices with active channels of indium selenide, bismuth chalcogenides and transition-metal dichalcogenides are stable in air. However, air-exposed indium selenide suffers of p-type doping due to water decomposition on Se vacancies, whereas the low mobility of charge carriers in transition-metal dichalcogenides increases the response time of nanodevices. Conversely, bismuth chalcogenides require a control of crystalline quality, which could represent a serious hurdle for up scaling.

Published
2018
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6. Terahertz detection of magnetic field-driven topological phase transition in HgTe-based transistors

Author

Kadykov, A., Teppe, F., Consejo, C., Viti, L., Vitiello, M., Coquillat, D., Ruffenach, S., Morozov, S., Kristopenko, S., Marcinkiewicz, M., Dyakonova, N., Knap, W., Gavrilenko, V., Michailov, N. N., and Dvoretskii, S. A.

Subjects
Condensed Matter - Mesoscale and Nanoscale Physics, Condensed Matter - Materials Science
Abstract

We report on Terahertz detection by inverted band structure HgTe-based Field Effect Transistor up to room temperature. At low temperature, we show that nonlinearities of the transistor channel allows for the observation of the quantum phase transition due to the avoided crossing of zero-mode Landau levels in HgTe 2D topological insulators. These results pave the way towards Terahertz topological Field Effect Transistors.

Published
2018
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8. Distributed feedback terahertz frequency quantum cascade lasers with dual periodicity gratings

Author

Castellano, F., Zanotto, S., Li, L. H., Pitanti, A., Tredicucci, A., Linfield, E. H., Davies, A. G., and Vitiello, M. S.

Subjects
Physics - Optics
Abstract

We have developed terahertz frequency quantum cascade lasers that exploit a double-periodicity distributed feedback grating to control the emission frequency and the output beam direction independently. The spatial refractive index modulation of the gratings necessary to provide optical feedback at a fixed frequency and, simultaneously, a far-field emission pattern centered at controlled angles, was designed through use of an appropriate wavevector scattering model. Single mode THz emission at angles tuned by design between 0{\deg} and 50{\deg} was realized, leading to an original phase-matching approach, lithographically independent, for highly collimated THz QCLs.

Published
2016
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9. Ultrafast single-nanowire multi-terahertz spectroscopy with sub-cycle temporal resolution

Author

Eisele, M., Cocker, T. L., Huber, M. A., Plankl, M., Viti, L., Ercolani, D., Sorba, L., Vitiello, M. S., and Huber, R.

Subjects
Condensed Matter - Mesoscale and Nanoscale Physics, Physics - Optics
Abstract

Phase-locked ultrashort pulses in the rich terahertz (THz) spectral range have provided key insights into phenomena as diverse as quantum confinement, first-order phase transitions, high-temperature superconductivity, and carrier transport in nanomaterials. Ultrabroadband electro-optic sampling of few-cycle field transients can even reveal novel dynamics that occur faster than a single oscillation cycle of light. However, conventional THz spectroscopy is intrinsically restricted to ensemble measurements by the diffraction limit. As a result, it measures dielectric functions averaged over the size, structure, orientation and density of nanoparticles, nanocrystals or nanodomains. Here, we extend ultrabroadband time-resolved THz spectroscopy (20 - 50 THz) to the sub-nanoparticle scale (10 nm) by combining sub-cycle, field-resolved detection (10 fs) with scattering-type near-field scanning optical microscopy (s-NSOM). We trace the time-dependent dielectric function at the surface of a single photoexcited InAs nanowire in all three spatial dimensions and reveal the ultrafast ($<$50 fs) formation of a local carrier depletion layer.

Published
2016
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11. Ecotoxicity Evaluation of Pristine and Indolicidin-coated Silver Nanoparticles in Aquatic and Terrestrial Ecosystem

Author

Falanga A, Siciliano A, Vitiello M, Franci G, Del Genio V, Galdiero S, Guida M, Carraturo F, Fahmi A, and Galdiero E

Subjects
nano-toxicology, silver nanoparticles, antimicrobial peptide indolicidin, in vivo toxicity, phytotoxicity, Medicine (General), R5-920
Abstract

Annarita Falanga,1 Antonietta Siciliano,2 Mariateresa Vitiello,3 Gianluigi Franci,4 Valentina Del Genio,5 Stefania Galdiero,5 Marco Guida,2 Federica Carraturo,2 Amir Fahmi,6,* Emilia Galdiero2,* 1Department of Agricultural Science, University of Naples Federico II, Portici 80055, Italy; 2Department of Biology, University of Naples Federico II, Naples 80100, Italy; 3Department of Clinical Pathology, Virology Unit, “San Giovanni di Dio e Ruggi d’Aragona Hospital”, Salerno, Italy; 4Department of Medicine, Surgery and Dentistry “Scuola Medica Salernitana,” University of Salerno, Baronissi, Italy; 5Department of Pharmacy, School of Medicine, University of Naples Federico II, Naples 80134, Italy; 6Rhein-Waal University of Applied Sciences, Kleve D-47533, Germany*These authors contributed equally to this workCorrespondence: Emilia Galdiero; Amir Fahmi Tel +39081679182Email egaldier@unina.it; Amir.fahmi@hochschule-Rhein-Waal.deBackground: Metallic nanoparticles (NPs) are highly exploited in manufacturing and medical processes in a broad spectrum of industrial applications and in the academic sectors. Several studies have suggested that many metallic nanomaterials including those derived by silver (Ag) are entering the ecosystem to cause significant toxic consequences in cell culture and animal models. However, ecotoxicity studies are still receiving limited attention when designing functionalized and non.-functionalized AgNPs.Objective: This study aimed to investigate different ecotoxicological profiles of AgNPs, which were analyzed in two different states: in pristine form uncoated AgNPs and coated AgNPs with the antimicrobial peptide indolicidin. These two types of AgNPs are exploited for a set of different tests using Daphnia magna and Raphidocelis subcapitata, which are representatives of two different levels of the aquatic trophic chain, and seeds of Lepidium sativum, Cucumis sativus and Lactuca sativa.Results: Ecotoxicological studies showed that the most sensitive organism to AgNPs was crustacean D. magna, followed by R. subcapitata and plant seeds, while AgNPs coated with indolicidin (IndAgNPs) showed a dose-dependent decreased toxicity for all three.Conclusion: The obtained results demonstrate that high ecotoxicity induced by AgNPs is strongly dependent on the surface chemistry, thus the presence of the antimicrobial peptide. This finding opens new avenues to design and fabricate the next generation of metallic nanoparticles to ensure the biosafety and risk of using engineered nanoparticles in consumer products.Keywords: silver nanoparticles, antimicrobial peptide indolicidin, in vivo toxicity, phytotoxicity, nanotoxicology

Published
2020

13. Graphene field effect transistors as room-temperature Terahertz detectors

Author

Vicarelli, L., Vitiello, M. S., Coquillat, D., Lombardo, A., Ferrari, A. C., Knap, W., Polini, M., Pellegrini, V., and Tredicucci, A.

Subjects
Condensed Matter - Mesoscale and Nanoscale Physics
Abstract

The unique optoelectronic properties of graphene [1] make it an ideal platform for a variety of photonic applications [2], including fast photodetectors [3], transparent electrodes [4], optical modulators [5], and ultra-fast lasers [6]. Owing to its high carrier mobility, gapless spectrum, and frequency-independent absorption coefficient, it has been recognized as a very promising element for the development of detectors and modulators operating in the Terahertz (THz) region of the electromagnetic spectrum (wavelengths in the hundreds of micrometers range), which is still severely lacking in terms of solid-state devices. Here we demonstrate efficient THz detectors based on antenna-coupled graphene field-effect transistors (FETs). These exploit the non-linear FET response to the oscillating radiation field at the gate electrode, with contributions of thermoelectric and photoconductive origin. We demonstrate room temperature (RT) operation at 0.3 THz, with noise equivalent power (NEP) levels < 30 nW/Hz^(1/2), showing that our devices are well beyond a proof-of-concept phase and can already be used in a realistic setting, enabling large area, fast imaging of macroscopic samples., Comment: 6 pages, 5 figures

Published
2012
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15. Perceived organizational support and work engagement: the role of psychosocial variables

Author

Bonaiuto, F., Fantinelli, S., Milani, A., Cortini, M., Vitiello, M. C., and Bonaiuto, M.

Subjects
Social support, Organizational Behavior and Human Resource Management, Work engagement, Social Psychology, Psychosocial risks, Organizational identification, Perceived organizational support, Development
Abstract

PurposeThis study aims to test the role that organizational sociopsychological variables may play in influencing job stress and work engagement in an organizational identity change scenario.Design/methodology/approachOn a sample of 118 employees of an Italian company in the personnel training services sector, multivariate statistical analysis tests a pattern where organizational variables such as work support (by supervisors and coworkers, independent variables) – moderated by corporate identification (moderating variable) – and mediated by organizational trust (mediating variable) – boosts employee work engagement and lowers psychosocial risks (dependent variables).FindingsThe mediating effect of “organizational trust” is significant in the relationships of “supervisor social support” and “coworker social support” with the “absence of psychosocial risks.” Moreover, an increase in supervisor social support can lead to a statistically significant increase in work engagement. This occurs only for employees with low or medium identification and not in highly identified individuals.Originality/valueThe findings from the analysis on moderation are of primary importance because they show us a new perspective that can play the role of a guiding and practical principle on how to act on an organization’s human resources, specifically targeting those with lower or medium corporate identification.

Published
2022

21. Self-assembled or mixed peptide amphiphile micelles from Herpes simplex virus glycoproteins as potential immunomodulatory treatment

Author

Accardo A, Vitiello M, Tesauro D, Galdiero M, Finamore E, Martora F, Mansi R, Ringhieri P, and Morelli G

Subjects
Medicine (General), R5-920
Abstract

Antonella Accardo,1 Mariateresa Vitiello,2,3 Diego Tesauro,1 Marilena Galdiero,2 Emiliana Finamore,2 Francesca Martora,2 Rosalba Mansi,1 Paola Ringhieri,1 Giancarlo Morelli11Department of Pharmacy, Interuniversitary Centre for Research on Bioactive peptides, CIRPeB, University of Naples "Federico II", Institute of Biostructures and Bioimaging IBB-CNR, Naples, Italy; 2Department of Experimental Medicine, Section of Microbiology and Clinical Microbiology, Second University of Naples, Naples, Italy; 3Department of Clinical Pathology and Transfusion Medicine, University Hospital “Ruggi d'Aragona”, Salerno, ItalyAbstract: The use of micelle aggregates formed from peptide amphiphiles (PAs) as potential synthetic self-adjuvant vaccines to treat Herpes simplex virus (HSV) infection are reported here. The PAs were based on epitopes gB409-505 and gD301-309, selected from HSV envelope glycoprotein B (gB) and glycoprotein D (gD), that had their N-terminus modified with hydrophobic moieties containing two C18 hydrocarbon chains. Pure and mixed micelles of gB and/or gD peptide epitopes were easily prepared after starting with the synthesis of corresponding PAs by solid phase methods. Structural characterization of the aggregates confirmed that they were sufficiently stable and compatible with in vivo use: critical micelle concentration values around 4.0 · 10-7 mol · Kg-1; hydrodynamic radii (RH) between 50–80 nm, and a zeta potential (ζ) around – 40 mV were found for all aggregates. The in vitro results indicate that both peptide epitopes and micelles, at 10 µM, triggered U937 and RAW 264.7 cells to release appreciable levels of cytokines. In particular, interleukin (IL)-23-, IL-6-, IL-8- or macrophage inflammatory protein (MIP)-2-, and tumor necrosis factor (TNF)-α-release increased considerably when cells were treated with the gB-micelles or gD-micelles compared with the production of the same cytokines when the stimulus was the single gB or gD peptide.Keywords: epitopes, self-adjuvant vaccine, HSV

Published
2014

22. Terahertz photodetection in scalable single-layer-graphene and hexagonal boron nitride heterostructures

Author

Asgari, M., primary, Viti, L., additional, Balci, O., additional, Shinde, S. M., additional, Zhang, J., additional, Ramezani, H., additional, Sharma, S., additional, Meersha, A., additional, Menichetti, G., additional, McAleese, C., additional, Conran, B., additional, Wang, X., additional, Tomadin, A., additional, Ferrari, A. C., additional, and Vitiello, M. S., additional

Published
2022
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23. Dendrimers functionalized with membrane-interacting peptides for viral inhibition

Author

Tarallo R, Carberry TP, Falanga A, Vitiello M, Galdiero S, Galdiero M, and Weck M

Subjects
Medicine (General), R5-920
Abstract

Rossella Tarallo,1 Tom P Carberry,2 Annarita Falanga,1 Mariateresa Vitiello,3 Stefania Galdiero,1 Massimiliano Galdiero,3 Marcus Weck21Dipartimento di Farmacia, Università di Napoli "Federico II," and DFM Scarl, Napoli, Italia; 2Molecular Design Institute and Department of Chemistry, New York University, New York, NY, USA; 3Dipartimento di Medicina Sperimentale, Seconda Università degli Studi di Napoli, Napoli, ItaliaAbstract: This contribution reports the synthesis of a poly(amide)-based dendrimer functionalized at the termini with a membrane-interacting peptide derived from the herpes simplex virus (HSV) type 1 glycoprotein H, namely gH625-644. This peptide has been shown to interact with model membranes and to inhibit viral infectivity. The peptidodendrimer inhibits both HSV-1 and HSV-2 at a very early stage of the entry process, most likely through an interaction with the viral envelope glycoproteins; thus, preventing the virus from coming into close contact with cellular membranes, a prerequisite of viral internalization. The 50% inhibitory concentration was 100 and 300 nM against HSV-1 and HSV-2 respectively, with no evidence of cell toxicity at these concentrations. These results show that the functionalization of a dendrimer with the peptide sequence derived from an HSV glycoprotein shows promising inhibitory activity towards viruses of the Herpesviridae family.Keywords: peptidodendrimer, antiviral activity, membranotropic peptides

Published
2013

24. Peptides complementary to the active loop of porin P2 from Haemophilus influenzae modulate its activity

Author

Galdiero S, Galdiero M, Finamore E, Falanga A, Vitiello M, and Cantisani M

Subjects
Medicine (General), R5-920
Abstract

Marco Cantisani,1 Mariateresa Vitiello,2 Annarita Falanga,1 Emiliana Finamore,2 Marilena Galdiero,2 Stefania Galdiero11Department of Biological Sciences, CIRPeB and IBB CNR, University of Naples "Federico II," Napoli, Italy; 2Department of Experimental Medicine, II University of Naples, Napoli, ItalyAbstract: Haemophilus influenzae type b (Hib) is one of the leading causes of invasive bacterial infection in young children. It is characterized by inflammation that is mainly mediated by cytokines and chemokines. One of the most abundant components of the Hib outer membrane is the P2 porin, which has been shown to induce the release of several inflammatory cytokines. A synthetic peptide corresponding to loop L7 of the porin activates JNK and p38 mitogen-activated protein kinase (MAPK) pathways. We report a novel use of the complementary peptide approach to design a peptide that is able to bind selectively to the protein P2, thereby reducing its activity. This work provides insights into essential molecular details of P2 that may affect the pathogenesis of Hib infections where interruption of the signaling cascade could represent an attractive therapeutic strategy.Keywords: complementary-peptide, rational design, porin

Published
2012

25. Immigrazione e mercato del lavoro in Europa meridionale: cos’è cambiato con la crisi economica?

Author

Bonifazi C., Buonomo A., Paparusso A., Strozza S., Vitiello M., Di Sanzo Donato, Bonifazi, C., Buonomo, A., Paparusso, A., Strozza, S., and Vitiello, M.

Subjects
Migrazioni internazionali, Stranieri residenti, Portogallo, indicatori del mercato del lavoro di nazionali e stranieri, Caratteristiche demografiche, Modello mediterraneo dell'immigrazione, Italia, Spagna, Grecia
Abstract

Il presente contributo, ripercorrendo e aggiornando alcune ricerche precedenti, ha lo scopo di analizzare l’evoluzione del fenomeno migratorio in Grecia, Portogallo, Italia e Spagna a partire dagli anni Novanta del secolo scorso, individuandone le principali caratteristiche prima e dopo la crisi economica internazionale del 2008. Inoltre, utilizzando i dati della Rilevazione delle Forze di Lavoro forniti da Eurostat, si vuole analizzare la partecipazione al mercato del lavoro dei nazionali e degli stranieri di età 15-64 anni residenti nei quattro paesi. Il contributo si articola nel modo seguente: dopo questa introduzione sulle caratteristiche del modello mediterraneo dell’immigrazione, il secondo paragrafo illustra la dinamica dei flussi migratori dei cittadini nazionali e di quelli stranieri nei quattro paesi dell’Europa meridionale considerati, negli anni 1992-2018; il terzo paragrafo analizza le dimensioni della presenza straniera in tali territori dal 1991 al 2019; il quarto paragrafo si focalizza sull’evoluzione della partecipazione al mercato del lavoro dei cittadini nazionali e stranieri, confrontando i tassi di occupazione e di disoccupazione di maschi e femmine per gli anni 2006-2018. Il contributo si conclude con alcune riflessioni di sintesi sul modello mediterraneo dell’immigrazione.

Published
2021

26. GJB5 association with BRAF mutation and survival in cutaneous malignant melanoma

Author

Scatolini, M., primary, Patel, A., additional, Grosso, E., additional, Mello-Grand, M., additional, Ostano, P., additional, Coppo, R., additional, Vitiello, M., additional, Venesio, T., additional, Zaccagna, A., additional, Pisacane, A., additional, Sarotto, I., additional, Taverna, D., additional, Poliseno, L., additional, Bergamaschi, D., additional, and Chiorino, G., additional

Published
2022
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27. Campylobacter jejuni bacteremia in Italian pediatric patients with acute lymphoblastic leukemia: Report of two cases

Author

Martora F., Pagliuca C., Della Pepa M. E., Della Rocca M. T., Curto S., Iovene M. R., Vitiello M., Martora, F., Pagliuca, C., Della Pepa, M. E., Della Rocca, M. T., Curto, S., Iovene, M. R., and Vitiello, M.

Subjects
Campylobacter jejuni, acute lymphoblastic leukemia (ALL), bacteremia
Abstract

Infections caused by Campylobacter jejuni are rarely associated with extraintestinal complications. C. jejuni bacteremia is difficult to detect in patients with hematological malignancies undergoing chemotherapy where the choice of appropriate antibiotic treatment is extremely important. We report two cases of C. jejuni bacteremia in Italian pediatric patients affected by acute lymphoblastic leukemia (ALL). Agreeing with the most recent epidemiological data, both clinical isolates showed a typical phenotypic antimicrobial resistance patterns with combined resistance to ciprofloxacin and tetracycline. To our knowledge, this is the first report of C. jejuni isolation from the blood of ALL pediatric patients in Italy, and it provides important epidemiological information on this rare infection.

Published
2020

28. The Bologna motor and non-motor prospective study on parkinsonism at onset (BoProPark): study design and population

Author

Calandra Buonaura G., Sambati L., Baschieri F., Vitiello M., Contin M., Tonon C., Capellari S., Provini F., Cortelli P., Barletta G., Caltabiano G., Cecere A., Gallassi R., Giannini G., Guaraldi P., Lodi R., Lopane G., Manners D. N., Martinelli P., Miele F., Mignani F., Mohamed S., Nassetti S., Oppi F., Parchi P., Pierangeli G., Poda R., Scaglione C., Solieri L., Stanzani Maserati M., Testa C., Calandra Buonaura G., Sambati L., Baschieri F., Vitiello M., Contin M., Tonon C., Capellari S., Provini F., Cortelli P., Barletta G., Caltabiano G., Cecere A., Gallassi R., Giannini G., Guaraldi P., Lodi R., Lopane G., Manners D.N., Martinelli P., Miele F., Mignani F., Mohamed S., Nassetti S., Oppi F., Parchi P., Pierangeli G., Poda R., Scaglione C., Solieri L., Stanzani Maserati M., and Testa C.

Subjects
0301 basic medicine, medicine.medical_specialty, Pediatrics, Motor symptoms, Neurology, Parkinson's disease, Atypical parkinsonisms, Population, Non-motor symptoms, Dermatology, Disease, Non-motor symptom, Levodopa, 03 medical and health sciences, 0302 clinical medicine, Parkinsonian Disorders, Motor symptom, medicine, Humans, Prospective Studies, Prospective cohort study, education, Aged, education.field_of_study, business.industry, Parkinsonism, Neurodegenerative Diseases, Parkinson Disease, Study design, General Medicine, Middle Aged, medicine.disease, Psychiatry and Mental health, 030104 developmental biology, Atypical parkinsonism, Parkinson’s disease, Original Article, Neurology (clinical), Neurosurgery, business, Cohort study, 030217 neurology & neurosurgery
Abstract

Objective The Bologna motor and non-motor prospective study on parkinsonism at onset (BoProPark) was designed to prospectively characterize motor and non-motor features in patients with a progressive neurodegenerative disease starting with parkinsonism since early disease stage and to investigate their diagnostic and prognostic role in the differential diagnosis of Parkinson’s disease from atypical parkinsonisms. The aim of this paper is to describe the method and population of the BoProPark study. Methods Patients referred to our Department with parkinsonism within 3 years from motor onset were recruited. Secondary causes of parkinsonism were excluded. Each patient underwent a comprehensive evaluation of motor and non-motor symptoms, assessed by means of quantitative, objective instrumental tests in addition to scales and questionnaires. The evaluations were performed at enrolment (T0), after 16 months (T1) and after 5 years (T2). Diagnoses were made according to consensus criteria. Results We recruited 150 patients, with mean age 61.5 ± 9.8 years and mean disease duration 20 ± 9 months. H&Y stage was 1 in 47.3% and 2 in 46.7% of cases. Mean UPDRS-III was 17.7 ± 9.2. Fifty-four patients were on dopaminergic treatment with median levodopa equivalent daily dose (LEDD) of 200 mg. Conclusions We expect that the prospective nature of the BoProPark study as well as the comprehensive, instrumental evaluation of motor and non-motor symptoms in patients with parkinsonism will provide important new insights for both clinical practice and research. Our data could be used for comparison with other cohorts and shared with national and international collaborators to develop new innovative projects.

Published
2020

30. Millimeter Wave Photonics with Terahertz Semiconductor Lasers

Author

Pistore, V., primary, Nong, H., additional, Vigneron, P-B., additional, Garrasi, K., additional, Houver, S., additional, Li, L., additional, Davies, A. G., additional, Linfield, E. H., additional, Tignon, J., additional, Mangeney, J., additional, Colombelli, R., additional, Vitiello, M. S., additional, and Dhillon, S. S., additional

Published
2021
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34. Nuovi flussi migratori, accoglienza e diritti umani. Nota introduttiva

Author

Accorinti M., Pugliese E., Vitiello M., Accorinti, M, Pugliese, E, and Vitiello, M

Subjects
rifugiati e richiedenti asilo, richiedenti asilo e rifugiati, studi sulle migrazioni in italia, normativa sull'asilo, politiche migratorie
Abstract

«Se l'analisi demografica permette di definire l'ampiezza delle migra-zioni bisogna mobilitare altre discipline per avere il senso delle loro di-verse dimensioni - geopolitiche, storiche, antropologiche, economiche ma anche giuridiche ed etiche. Ciò perché le migrazioni, legate all'ori-gine ai bisogni delle economie nazionali, sono state sempre più alimen-tate dalla logica dei diritti universali: una mutazione decisiva e al con-tempo fragile». Così si espresse François Héran nella lezione al Collège de France in occasione della cattedra assegnatagli nel 2018 pubblicata da Fayard. Il processo che lo studioso francese mette in luce riguarda un periodo molto lungo. Ma in Italia esso si è mostrato nel giro di pochissimi anni. Si è verificata infatti nel corso di questo decennio una progressiva radi-cale modificazione dei flussi migratori spostando il focus delle politiche da quello tradizionale della gestione dell'ingresso e della collocazione dei migranti per lavoro - ambito sostanzialmente economico - a quello di gestione del flusso di rifugiati e richiedenti asilo - ambito prevalentemente dei diritti umani o meglio universali come ritiene Héran. Ed è essenzialmente di questo che si sta discutendo attualmente in Italia ed è su questo che si è esercitata anche la produzione legislativa - ca-ratterizzata dalla pratica della decretazione d'urgenza - affrontando con grande difficoltà temi che proprio per il carattere umano o universale delle questioni trattate pongono dei vincoli, a volte stringenti, e dei li-miti alla legislazione nazionale. Così la materia dei rifugiati e dei richie-denti asilo è in primo luogo regolata nei suoi termini generali da una convenzione internazionale che fa obbligo agli Stati aderenti di acco-gliere coloro che sono definiti tali.

Published
2019

35. West Nile virus: an overview of current information

Author

Chianese A, Stelitano D, Astorri R, Serretiello E, Vitiello M, Galdiero M, Franci G, Chianese, A, Stelitano, D, Astorri, R, Serretiello, E, Vitiello, M, Galdiero, M, and Franci, G

Published
2019

47. In Search of Protection: Unaccompanied Minors in Italy

Author

Demurtas P, Vitiello M, Accorinti M, Skoda A, Perillo C, Demurtas, P, Vitiello, M, Accorinti, M, Skoda, A, and Perillo, C

Subjects
immigration in Italy, unaccompained minor, social policy for minors
Abstract

This paper examines the issue of unaccompanied minors arriving in Italy and how Italy has responded to their need for protection. It contains ¡ve complementary sections. Section 1, authored by Pietro Demurtas, provides a statistical overview of unaccompanied minors in Italy between 2014 and 2017. In particular, it discusses unaccompanied minors who request political asylum, those in government reception facilities who do not, and those who have left reception centers without seeking asylum and have become "untraceable." The second section by Mattia Vitiello addresses why unaccompanied minors leave their countries of origin and how they transit to Italy and elsewhere. This section highlights the role of families in the decision to migrate and the migration process. It distinguishes unaccompanied minors who largely seek to "escape from" particular conditions from other migrants who are in search of a better life for themselves and their families. The third section by Marco Accorinti covers Italian reception policies and policymaking challenges, with a particular focus on implementation of Italy's System for the Protection of Asylum Seekers and Refugees. The section argues for reception procedures and interventions that are tailored to the particular vulnerabilities and needs of unaccompanied minors. Section 4, authored by Aldo Skoda, c.s., offers a psychosocial analysis of the phenomenon of unaccompanied child migration. It describes strategies to build the competencies, sense of agency, and resilience of unaccompanied minors. The final section, authored by Carola Perillo, details the demands and requirements of acting in the "best interests" of unaccompanied minors. It ends by setting forth minimum principles of protection for unaccompanied minors, which should inform both the Global Compact on Migration and the Global Compact on Refugees.

Published
2018

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