1,560 results on '"Vitiello, Benedetto"'
Search Results
2. Female Autism and Externalizing Disorders
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Davico, Chiara, Lux, Caterina, Vitiello, Benedetto, Mazzone, Luigi, editor, Siracusano, Martina, editor, and Pelphrey, Kevin A., editor
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- 2024
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3. Internalizing Disorders and Female Autism
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Davico, Chiara, Secci, Ilaria, Vitiello, Benedetto, Mazzone, Luigi, editor, Siracusano, Martina, editor, and Pelphrey, Kevin A., editor
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- 2024
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4. Semantic Coherence Markers for the Early Diagnosis of the Alzheimer Disease
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Colla, Davide, Delsanto, Matteo, Agosto, Marco, Vitiello, Benedetto, and Radicioni, Daniele Paolo
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Computer Science - Computation and Language ,Computer Science - Artificial Intelligence - Abstract
In this work we explore how language models can be employed to analyze language and discriminate between mentally impaired and healthy subjects through the perplexity metric. Perplexity was originally conceived as an information-theoretic measure to assess how much a given language model is suited to predict a text sequence or, equivalently, how much a word sequence fits into a specific language model. We carried out an extensive experimentation with the publicly available data, and employed language models as diverse as N-grams, from 2-grams to 5-grams, and GPT-2, a transformer-based language model. We investigated whether perplexity scores may be used to discriminate between the transcripts of healthy subjects and subjects suffering from Alzheimer Disease (AD). Our best performing models achieved full accuracy and F-score (1.00 in both precision/specificity and recall/sensitivity) in categorizing subjects from both the AD class and control subjects. These results suggest that perplexity can be a valuable analytical metrics with potential application to supporting early diagnosis of symptoms of mental disorders., Comment: This paper is the (significantly) abridged version of the article "Semantic coherence markers: The contribution of perplexity metrics" (https://doi.org/10.1016/j.artmed.2022.102393), which also contains references to employed data and to the implementation of the described work
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- 2023
5. CRISIS AFAR: an international collaborative study of the impact of the COVID-19 pandemic on mental health and service access in youth with autism and neurodevelopmental conditions
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Vibert, Bethany, Segura, Patricia, Gallagher, Louise, Georgiades, Stelios, Pervanidou, Panagiota, Thurm, Audrey, Alexander, Lindsay, Anagnostou, Evdokia, Aoki, Yuta, Birken, Catherine S, Bishop, Somer L, Boi, Jessica, Bravaccio, Carmela, Brentani, Helena, Canevini, Paola, Carta, Alessandra, Charach, Alice, Costantino, Antonella, Cost, Katherine T, Cravo, Elaine A, Crosbie, Jennifer, Davico, Chiara, Donno, Federica, Fujino, Junya, Gabellone, Alessandra, Geyer, Cristiane T, Hirota, Tomoya, Kanne, Stephen, Kawashima, Makiko, Kelley, Elizabeth, Kim, Hosanna, Kim, Young Shin, Kim, So Hyun, Korczak, Daphne J, Lai, Meng-Chuan, Margari, Lucia, Marzulli, Lucia, Masi, Gabriele, Mazzone, Luigi, McGrath, Jane, Monga, Suneeta, Morosini, Paola, Nakajima, Shinichiro, Narzisi, Antonio, Nicolson, Rob, Nikolaidis, Aki, Noda, Yoshihiro, Nowell, Kerri, Polizzi, Miriam, Portolese, Joana, Riccio, Maria Pia, Saito, Manabu, Schwartz, Ida, Simhal, Anish K, Siracusano, Martina, Sotgiu, Stefano, Stroud, Jacob, Sumiya, Fernando, Tachibana, Yoshiyuki, Takahashi, Nicole, Takahashi, Riina, Tamon, Hiroki, Tancredi, Raffaella, Vitiello, Benedetto, Zuddas, Alessandro, Leventhal, Bennett, Merikangas, Kathleen, Milham, Michael P, and Di Martino, Adriana
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Biological Psychology ,Psychology ,Brain Disorders ,Pediatric ,Intellectual and Developmental Disabilities (IDD) ,Mental Health ,Autism ,Neurosciences ,Mental health ,Good Health and Well Being ,Female ,Humans ,Adolescent ,Child ,COVID-19 ,Autistic Disorder ,Pandemics ,Autism Spectrum Disorder ,Cross-Sectional Studies ,Mental health outcomes ,Autism spectrum disorder ,Neurodevelopmental conditions ,Sleep ,Behavioral problems ,Prediction ,Risk and resilience factors ,COVID-19 pandemic ,Public health ,Clinical Sciences ,Clinical sciences ,Biological psychology - Abstract
BackgroundHeterogeneous mental health outcomes during the COVID-19 pandemic are documented in the general population. Such heterogeneity has not been systematically assessed in youth with autism spectrum disorder (ASD) and related neurodevelopmental disorders (NDD). To identify distinct patterns of the pandemic impact and their predictors in ASD/NDD youth, we focused on pandemic-related changes in symptoms and access to services.MethodsUsing a naturalistic observational design, we assessed parent responses on the Coronavirus Health and Impact Survey Initiative (CRISIS) Adapted For Autism and Related neurodevelopmental conditions (AFAR). Cross-sectional AFAR data were aggregated across 14 European and North American sites yielding a clinically well-characterized sample of N = 1275 individuals with ASD/NDD (age = 11.0 ± 3.6 years; n females = 277). To identify subgroups with differential outcomes, we applied hierarchical clustering across eleven variables measuring changes in symptoms and access to services. Then, random forest classification assessed the importance of socio-demographics, pre-pandemic service rates, clinical severity of ASD-associated symptoms, and COVID-19 pandemic experiences/environments in predicting the outcome subgroups.ResultsClustering revealed four subgroups. One subgroup-broad symptom worsening only (20%)-included youth with worsening across a range of symptoms but with service disruptions similar to the average of the aggregate sample. The other three subgroups were, relatively, clinically stable but differed in service access: primarily modified services (23%), primarily lost services (6%), and average services/symptom changes (53%). Distinct combinations of a set of pre-pandemic services, pandemic environment (e.g., COVID-19 new cases, restrictions), experiences (e.g., COVID-19 Worries), and age predicted each outcome subgroup.LimitationsNotable limitations of the study are its cross-sectional nature and focus on the first six months of the pandemic.ConclusionsConcomitantly assessing variation in changes of symptoms and service access during the first phase of the pandemic revealed differential outcome profiles in ASD/NDD youth. Subgroups were characterized by distinct prediction patterns across a set of pre- and pandemic-related experiences/contexts. Results may inform recovery efforts and preparedness in future crises; they also underscore the critical value of international data-sharing and collaborations to address the needs of those most vulnerable in times of crisis.
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- 2023
6. Therapeutic outcome and long-term naturalistic follow-up of female adolescent outpatients with AN: clinical, personality and psychopathology evolution, process indicators and outcome predictors
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Amianto, Federico, Arletti, Luca, Vesco, Serena, Davico, Chiara, and Vitiello, Benedetto
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- 2023
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7. Parental Care and Binge-Eating Disorder
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Amianto, Federico, Vitiello, Benedetto, Patel, Vinood B., editor, and Preedy, Victor R., editor
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- 2023
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8. Psychopharmacology in children and adolescents: unmet needs and opportunities
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Cortese, Samuele, Purper-Ouakil, Diane, Apter, Alan, Arango, Celso, Baeza, Inmaculada, Banaschewski, Tobias, Buitelaar, Jan, Castro-Fornieles, Josefina, Coghill, David, Cohen, David, Correll, Christoph U, Grünblatt, Edna, Hoekstra, Pieter J, James, Anthony, Jeppesen, Pia, Nagy, Péter, Pagsberg, Anne Katrine, Parellada, Mara, Persico, Antonio M, Roessner, Veit, Santosh, Paramala, Simonoff, Emily, Stevanovic, Dejan, Stringaris, Argyris, Vitiello, Benedetto, Walitza, Susanne, Weizman, Abraham, Wong, Ian C K, Zalsman, Gil, Zuddas, Alessandro, Carucci, Sara, Butlen-Ducuing, Florence, Tome, Maria, Bea, Myriam, Getin, Christine, Hovén, Nina, Konradsson-Geuken, Asa, Lamirell, Daphne, Olisa, Nigel, Nafria Escalera, Begonya, and Moreno, Carmen
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- 2024
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9. The World Federation of ADHD International Consensus Statement: 208 Evidence-based conclusions about the disorder
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Faraone, Stephen V, Banaschewski, Tobias, Coghill, David, Zheng, Yi, Biederman, Joseph, Bellgrove, Mark A, Newcorn, Jeffrey H, Gignac, Martin, Al Saud, Nouf M, Manor, Iris, Rohde, Luis Augusto, Yang, Li, Cortese, Samuele, Almagor, Doron, Stein, Mark A, Albatti, Turki H, Aljoudi, Haya F, Alqahtani, Mohammed MJ, Asherson, Philip, Atwoli, Lukoye, Bölte, Sven, Buitelaar, Jan K, Crunelle, Cleo L, Daley, David, Dalsgaard, Søren, Döpfner, Manfred, Espinet, Stacey, Fitzgerald, Michael, Franke, Barbara, Gerlach, Manfred, Haavik, Jan, Hartman, Catharina A, Hartung, Cynthia M, Hinshaw, Stephen P, Hoekstra, Pieter J, Hollis, Chris, Kollins, Scott H, Kooij, JJ Sandra, Kuntsi, Jonna, Larsson, Henrik, Li, Tingyu, Liu, Jing, Merzon, Eugene, Mattingly, Gregory, Mattos, Paulo, McCarthy, Suzanne, Mikami, Amori Yee, Molina, Brooke SG, Nigg, Joel T, Purper-Ouakil, Diane, Omigbodun, Olayinka O, Polanczyk, Guilherme V, Pollak, Yehuda, Poulton, Alison S, Rajkumar, Ravi Philip, Reding, Andrew, Reif, Andreas, Rubia, Katya, Rucklidge, Julia, Romanos, Marcel, Ramos-Quiroga, J Antoni, Schellekens, Arnt, Scheres, Anouk, Schoeman, Renata, Schweitzer, Julie B, Shah, Henal, Solanto, Mary V, Sonuga-Barke, Edmund, Soutullo, César, Steinhausen, Hans-Christoph, Swanson, James M, Thapar, Anita, Tripp, Gail, van de Glind, Geurt, van den Brink, Wim, Van der Oord, Saskia, Venter, Andre, Vitiello, Benedetto, Walitza, Susanne, and Wang, Yufeng
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Epidemiology ,Health Sciences ,Behavioral and Social Science ,Mental Illness ,Brain Disorders ,Clinical Research ,Attention Deficit Hyperactivity Disorder (ADHD) ,Mental Health ,Comparative Effectiveness Research ,Pediatric ,Mental health ,Attention Deficit Disorder with Hyperactivity ,Humans ,Network Meta-Analysis ,Publication Bias ,ADHD ,Diagnosis ,Treatment ,Course ,Outcome ,Genetics ,Brain ,Medical and Health Sciences ,Psychology and Cognitive Sciences ,Behavioral Science & Comparative Psychology ,Biomedical and clinical sciences ,Health sciences - Abstract
BackgroundMisconceptions about ADHD stigmatize affected people, reduce credibility of providers, and prevent/delay treatment. To challenge misconceptions, we curated findings with strong evidence base.MethodsWe reviewed studies with more than 2000 participants or meta-analyses from five or more studies or 2000 or more participants. We excluded meta-analyses that did not assess publication bias, except for meta-analyses of prevalence. For network meta-analyses we required comparison adjusted funnel plots. We excluded treatment studies with waiting-list or treatment as usual controls. From this literature, we extracted evidence-based assertions about the disorder.ResultsWe generated 208 empirically supported statements about ADHD. The status of the included statements as empirically supported is approved by 80 authors from 27 countries and 6 continents. The contents of the manuscript are endorsed by 366 people who have read this document and agree with its contents.ConclusionsMany findings in ADHD are supported by meta-analysis. These allow for firm statements about the nature, course, outcome causes, and treatments for disorders that are useful for reducing misconceptions and stigma.
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- 2021
10. Learning with fun: the 2nd residential course on child and adolescent psychiatry in Catania, Sicily, endorsed by the ESCAP Research Academy
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Riccioni, Assia, Siracusano, Martina, Davico, Chiara, Klauser, Paul, Morcillo, Carmen, Ougrin, Dennis, Vitiello, Benedetto, Plessen, Kerstin J., Armando, Marco, Cortese, Samuele, and Mazzone, Luigi
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- 2023
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11. Paths to Postsecondary Education Enrollment among Adolescents with and without Childhood Attention-Deficit/Hyperactivity Disorder (ADHD): A Longitudinal Analysis of Symptom and Academic Trajectories
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Di Lonardo Burr, Sabrina M., LeFevre, Jo-Anne, Arnold, L. Eugene, Epstein, Jeffrey N., Hinshaw, Stephen P., Molina, Brooke S. G., Hechtman, Lily, Hoza, Betsy, Jensen, Peter S., Vitiello, Benedetto, Pelham, William E., and Howard, Andrea L.
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We examined developmental trajectories of attention-deficit/hyperactivity disorder (ADHD) symptoms, standardized achievement, and school performance for adolescents with and without ADHD who did and did not enroll in postsecondary education (PSE; N = 749; 79% boys; 63% White, 17% non-Hispanic Black, 10% Hispanic, and 10% other ethnicities). In a multisite study (recruitment based in New York, North Carolina, Pennsylvania, California, and Quebec), participants were originally enrolled between 1994 and 1998 at ages 7 to 9.9 and followed up through 2012 (M[subscript age] = 25 at final follow-up). Adolescents who eventually enrolled in PSE had less severe symptoms, but differences were modest and trajectories were similar over time. For all adolescents, standardized achievement trajectories declined up to two thirds of a standard deviation from ages 9 to 17. By the end of high school, the average GPA of adolescents with ADHD was three quarters of a point higher for those who eventually enrolled in PSE compared to those who did not. Overall, school performance mattered more than academic achievement for understanding eventual enrollment of adolescents with ADHD.
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- 2022
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12. Trends in admissions to a child and adolescent neuropsychiatric inpatient unit in the 2007–2017 decade: how contemporary neuropsychiatry is changing in Northwestern Italy
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Amianto, Federico, Arletti, Luca, Baietto, Chiara, Davico, Chiara, Migliaretti, Giuseppe, and Vitiello, Benedetto
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- 2022
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13. The future of child and adolescent clinical psychopharmacology: A systematic review of phase 2, 3, or 4 randomized controlled trials of pharmacologic agents without regulatory approval or for unapproved indications
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Cortese, Samuele, McGinn, Katherine, Højlund, Mikkel, Apter, Alan, Arango, Celso, Baeza, Immaculada, Banaschewski, Tobias, Buitelaar, Jan, Castro-Fornieles, Josefina, Coghill, David, Cohen, David, Grünblatt, Edna, Hoekstra, Pieter J., James, Anthony, Jeppesen, Pia, Nagy, Péter, Pagsberg, Anne Katrine, Parellada, Mara, Persico, Antonio M., Purper-Ouakil, Diane, Roessner, Veit, Santosh, Paramala, Simonoff, Emily, Stevanovic, Dejan, Stringaris, Argyris, Vitiello, Benedetto, Walitza, Susanne, Weizman, Abraham, Wohlfarth, Tamar, Wong, Ian C.K., Zalsman, Gil, Zuddas, Alessandro, Moreno, Carmen, Solmi, Marco, and Correll, Christoph U.
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- 2023
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14. Sleep disturbances and emotional dysregulation in young children with autism spectrum, intellectual disability, or global developmental delay
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Favole, Irene, Davico, Chiara, Marcotulli, Daniele, Sodero, Roberta, Svevi, Barbara, Amianto, Federico, Ricci, Federica S., Arduino, G. Maurizio, and Vitiello, Benedetto
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- 2023
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15. Population Density and Suicide Risk
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Vitiello, Benedetto, Vichi, Monica, Davico, Chiara, Ghirini, Silvia, Pompili, Maurizio, and Pompili, Maurizio, editor
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- 2022
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16. Epilepsy in a cohort of children with Noonan syndrome and related disorders
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Davico, Chiara, D’Alessandro, Rossella, Borgogno, Marta, Campagna, Filippa, Torta, Francesca, Ricci, Federica, Amianto, Federico, Vittorini, Roberta, Carli, Diana, Mussa, Alessandro, Vitiello, Benedetto, and Ferrero, Giovanni Battista
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- 2022
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17. Impact of war and forced displacement on children’s mental health—multilevel, needs-oriented, and trauma-informed approaches
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Bürgin, David, Anagnostopoulos, Dimitris, Vitiello, Benedetto, Sukale, Thorsten, Schmid, Marc, and Fegert, Jörg M.
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- 2022
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18. Obsessive–compulsive symptoms in young women affected with anorexia nervosa, and their relationship with personality, psychopathology, and attachment style
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Amianto, Federico, Secci, Ilaria, Arletti, Luca, Davico, Chiara, Abbate Daga , Giovanni, and Vitiello, Benedetto
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- 2022
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19. Semantic coherence markers: The contribution of perplexity metrics
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Colla, Davide, Delsanto, Matteo, Agosto, Marco, Vitiello, Benedetto, and Radicioni, Daniele P.
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- 2022
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20. Cigarette Smoking Progression Among Young Adults Diagnosed With ADHD in Childhood: A 16-year Longitudinal Study of Children With and Without ADHD.
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Mitchell, John T, Howard, Andrea L, Belendiuk, Katherine A, Kennedy, Traci M, Stehli, Annamarie, Swanson, James M, Hechtman, Lily, Arnold, L Eugene, Hoza, Betsy, Vitiello, Benedetto, Lu, Bo, Kollins, Scott H, and Molina, Brooke SG
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Pediatric Research Initiative ,Mental Health ,Behavioral and Social Science ,Attention Deficit Hyperactivity Disorder (ADHD) ,Clinical Research ,Tobacco Smoke and Health ,Prevention ,Brain Disorders ,Tobacco ,Substance Misuse ,Pediatric ,Respiratory ,Good Health and Well Being ,Adolescent ,Adult ,Attention Deficit Disorder with Hyperactivity ,Child ,Cigarette Smoking ,Combined Modality Therapy ,Disease Progression ,Female ,Humans ,Longitudinal Studies ,Male ,Prognosis ,Smoking Cessation ,Time Factors ,Tobacco Use Disorder ,Young Adult ,Clinical Sciences ,Public Health and Health Services ,Marketing ,Public Health - Abstract
INTRODUCTION:Children with attention-deficit/hyperactivity disorder (ADHD) are at increased risk for smoking cigarettes, but there is little longitudinal research on the array of smoking characteristics known to be prognostic of long-term smoking outcomes into adulthood. These variables were studied into early adulthood in a multisite sample diagnosed with ADHD combined type at ages 7-9.9 and followed prospectively alongside an age- and sex-matched local normative comparison group (LNCG). METHODS:Cigarette smoking quantity, quit attempts, dependence, and other characteristics were assessed in the longitudinal Multimodal Treatment Study of Children with ADHD (MTA) eight times to a mean age of 24.9 years: ADHD n = 469; LNCG n = 240. RESULTS:In adulthood, the ADHD group had higher rates of daily cigarette smoking, one or more quit attempts, shorter time to first cigarette of the day, and more severe withdrawal than the LNCG. The ADHD group did not appear to have better smoking cessation rates despite a higher proportion quitting at least once. Smoking quantity and nicotine dependence did not differ between groups. The ADHD group reported younger daily smoking onset and faster progression from smoking initiation to daily smoking across assessments. Finally, ADHD symptom severity in later adolescence and adulthood was associated with higher risk for daily smoking across assessments in the ADHD sample. CONCLUSIONS:This study shows that ADHD-related smoking risk begins at a young age, progresses rapidly, and becomes resistant to cessation attempts by adulthood. Prevention efforts should acknowledge the speed of uptake; treatments should target the higher relapse risk in this vulnerable population. IMPLICATIONS:Although childhood ADHD predicts later smoking, longitudinal studies of this population have yet to fully characterize smoking behaviors into adulthood that are known to be prognostic of long-term smoking outcome. The current study demonstrates earlier and faster progression to daily smoking among those with a childhood ADHD diagnosis, as well as greater risk for failed quit attempts. Prevention efforts should address speed of smoking uptake, while treatments are needed that address smoking relapse risk. The current study also demonstrates ADHD symptom severity over development increases daily smoking risk, implicating the need for continuous ADHD symptom management.
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- 2019
21. An exploration of concomitant psychiatric disorders in children with autism spectrum disorder
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Lecavalier, Luc, McCracken, Courtney E, Aman, Michael G, McDougle, Christopher J, McCracken, James T, Tierney, Elaine, Smith, Tristram, Johnson, Cynthia, King, Bryan, Handen, Benjamin, Swiezy, Naomi B, Eugene Arnold, L, Bearss, Karen, Vitiello, Benedetto, and Scahill, Lawrence
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Clinical and Health Psychology ,Psychology ,Clinical Research ,Pediatric Research Initiative ,Pediatric ,Brain Disorders ,Behavioral and Social Science ,Violence Research ,Mental Health ,Intellectual and Developmental Disabilities (IDD) ,Autism ,Clinical Trials and Supportive Activities ,Attention Deficit Hyperactivity Disorder (ADHD) ,Aetiology ,2.3 Psychological ,social and economic factors ,Mental health ,Good Health and Well Being ,Adolescent ,Anxiety Disorders ,Attention Deficit Disorder with Hyperactivity ,Attention Deficit and Disruptive Behavior Disorders ,Autism Spectrum Disorder ,Child ,Child ,Preschool ,Comorbidity ,Conduct Disorder ,Female ,Humans ,Male ,Mood Disorders ,Autism spectrum disorder ,Psychiatric disorder ,Attention deficit hyperactivity disorder ,Disruptive behavior ,Anxiety ,Clinical Sciences ,Psychiatry ,Clinical sciences ,Clinical and health psychology - Abstract
ObjectiveWe explored patterns of concomitant psychiatric disorders in a large sample of treatment-seeking children and adolescents with autism spectrum disorder (ASD).MethodsParticipants were 658 children with ASD (age 3-17 years; mean = 7.2 years) in one of six federally-funded multisite randomized clinical trials (RCT) between 1999 and 2014. All children were referred for hyperactivity or irritability. Study designs varied, but all used the Child and Adolescent Symptom Inventory or Early Childhood Inventory to assess Attention Deficit Hyperactivity Disorder (ADHD), Oppositional-Defiant Disorder (ODD), Conduct Disorder (CD), Anxiety Disorders, and Mood Disorders. In addition, several measures in common were used to assess demographic and clinical characteristics.ResultsOf the 658 children, 73% were Caucasian and 59% had an IQ >70. The rates of concomitant disorders across studies were: ADHD 81%, ODD 46%, CD 12%, any anxiety disorder 42%, and any mood disorder 8%. Two or more psychiatric disorders were identified in 66% of the sample. Of those who met criteria for ADHD, 50% also met criteria for ODD and 46% for any anxiety disorder. Associations between types of concomitant disorders and a number of demographic and clinical characteristics are presented.ConclusionIn this well-characterized sample of treatment-seeking children with ASD, rates of concomitant psychiatric disorders were high and the presence of two or more co-occurring disorders was common. Findings highlight the importance of improving diagnostic practice in ASD and understanding possible mechanisms of comorbidity.
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- 2019
22. Cognitive, neuropsychological and emotional-behavioural functioning in a sample of children with myotonic dystrophy type 1
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Ricci, Federica S., Vacchetti, Martina, Brusa, Chiara, D'Alessandro, Rossella, La Rosa, Paola, Martone, Gianluca, Davico, Chiara, Vitiello, Benedetto, and Mongini, Tiziana E.
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- 2022
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23. The transition from adolescence to adulthood in patients with schizophrenia: Challenges, opportunities and recommendations
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Arango, Celso, Buitelaar, Jan K., Correll, Christoph U., Díaz-Caneja, Covadonga M., Figueira, Maria L., Fleischhacker, W. Wolfgang, Marcotulli, Daniele, Parellada, Mara, and Vitiello, Benedetto
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- 2022
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24. Acute Tolerability of Methylphenidate in Treatment-Naïve Children with ADHD: An Analysis of Naturalistically Collected Data from Clinical Practice
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Masi, Gabriele, Pfanner, Chiara, Liboni, Francesca, Lenzi, Francesca, Villafranca, Arianna, D’Acunto, Giulia, Fantozzi, Pamela, Falcone, Francesca, Simonelli, Valerio, Muratori, Pietro, Levantini, Valentina, Favole, Irene, Amianto, Federico, Davico, Chiara, and Vitiello, Benedetto
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- 2022
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25. Development and application of a diagnostic and severity scale to grade post-operative pediatric cerebellar mutism syndrome
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Ricci, Federica S., D’Alessandro, Rossella, Somà, Alessandra, Salvalaggio, Anna, Rossi, Francesca, Rampone, Sara, Gamberini, Giorgia, Davico, Chiara, Peretta, Paola, Cacciacarne, Mario, Gaglini, Pierpaolo, Pacca, Paolo, Pilloni, Giulia, Ragazzi, Paola, Bertin, Daniele, Vallero, Stefano G., Fagioli, Franca, and Vitiello, Benedetto
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- 2022
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26. Development of a Symptom-Focused Model to Guide the Prescribing of Antipsychotics in Children and Adolescents: Results of the First Phase of the Safer Use of Antipsychotics in Youth (SUAY) Clinical Trial
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Penfold, Robert B., Thompson, Ella E., Hilt, Robert J., Schwartz, Nadine, Robb, Adelaide S., Correll, Christoph U., Newton, Douglas, Rogalski, Kelly, Earls, Marian F., Kowatch, Robert A., Beck, Arne, Yarborough, Bobbi Jo H., Crystal, Stephen, Vitiello, Benedetto, Kelleher, Kelly J., and Simon, Gregory E.
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- 2022
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27. Comparison among anorexia nervosa adolescents with or without previous overweight, obese, and healthy adolescents.
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Amianto, Federico, Sertori, Francesca, Davico, Chiara, Marcotulli, Daniele, and Vitiello, Benedetto
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TEENAGE girls ,ANOREXIA nervosa ,ANALYSIS of covariance ,EATING disorders ,PATHOLOGICAL psychology - Abstract
Background: Anorexia nervosa (AN) and obesity (OB) are relevant concerns in adolescence. Despite their contrasting phenotypes, they share common pathogenic origins and may be present in the same individual at different times. We explored the psychopathology and attachment features of adolescents with AN who did (AN-ow) or did not (AN-nw) have previous overweight, compared with OB adolescents and healthy control (HC) adolescents. Method: In total, 148 female adolescents referred to an outpatient clinic for an eating disorder (66 for AN and 42 for OB) and 40 HCs were assessed using self-administered instruments that measured parenting, attachment, eating, and general psychopathology. Group differences were tested by analysis of covariance, and correlations between variables were examined. Results: AN-ow, AN-nw, and OB adolescents had greater interpersonal distrust and avoidance of relationships, compared with HC adolescents. AN-nw and AN-ow adolescents displayed a higher need for approval and a drive to thinness and interpersonal distrust, compared with HC adolescents. AN-ow adolescents displayed lower paternal care and higher ineffectiveness, asceticism, social insecurity, and depression, compared with HC adolescents. Compared with AN-nw adolescents, AN-ow adolescents felt more ineffective and more ascetic. The dynamics linking the psychopathological features clearly distinguished the four groups. Conclusions: AN-ow is a well-identified subtype of AN, with specific features that differ from AN-nw; some of these features are shared with OB. A therapeutic approach tailored to AN-ow adolescents should consider these features. [ABSTRACT FROM AUTHOR]
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- 2024
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28. Psychological Effects of Nasogastric Tube (NGT) in Patients with Anorexia Nervosa: A Systematic Review.
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Amianto, Federico, Oliaro, Tomaso, Righettoni, Francesca, Davico, Chiara, Marcotulli, Daniele, and Vitiello, Benedetto
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Aim: After the COVID-19 pandemic, the need for intensive nutritional care in patients affected with anorexia nervosa (AN) increased. The use of NGT was often used to overcome renutrition difficulties. This systematic review explores the evidence concerning the psychological effects of an enteral nasogastric tube (NGT) feeding on patients with AN. Methods: A systematic review following PRISMA guidelines was conducted on electronic databases, including papers from January 2010 to December 2023. The keywords used combined anorexia nervosa, NGT, nasogastric tube, and tube feeding, with MeSH terms. No language limit was imposed. Reviews were excluded from the search. Results: A total of 241 studies matched the keywords. Nevertheless, 236 studies were excluded from the review because they did not match the inclusion criteria. A total of six studies met the inclusion criteria. Of these, three studies were case series, one was a quantitative study of follow up and one was a qualitative exploratory study. The included studies described the hospitalization of patients with AN treated with a nasogastric tube; among these, only one study focused directly on the psychological correlates of nasogastric tube treatment using interviews with patients and medical staff. Included studies suggest that NGT feeding, even if faced in the first instance with prejudices and fears by patients, parents, and staff, is useful not only for weight increase in treatment-resistant patients with AN, but also alleviates their stress from feeding and, in general, it is psychologically well tolerated. Nevertheless, recent in-depth research on the issue is lacking and the existing has a low methodological quality; thus, many psychological effects of NGT application remain underexplored. Conclusions: Although the results suggest good psychological tolerance of the device, the limited data available recommend that more attention should be addressed by the researchers to the psychological consequences of the use of NGT in the treatment of AN since it is a nutrition disorder with prominent psychological roots. Further studies are needed. [ABSTRACT FROM AUTHOR]
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- 2024
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29. Obituary for Alessandro Zuddas
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Moreno, Carmen, Vitiello, Benedetto, and Hoekstra, Pieter
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- 2023
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30. Substance use through adolescence into early adulthood after childhood‐diagnosed ADHD: findings from the MTA longitudinal study
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Molina, Brooke SG, Howard, Andrea L, Swanson, James M, Stehli, Annamarie, Mitchell, John T, Kennedy, Traci M, Epstein, Jeffery N, Arnold, L Eugene, Hechtman, Lily, Vitiello, Benedetto, and Hoza, Betsy
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Paediatrics ,Biomedical and Clinical Sciences ,Pediatric Research Initiative ,Clinical Research ,Prevention ,Drug Abuse (NIDA only) ,Substance Misuse ,Pediatric ,Attention Deficit Hyperactivity Disorder (ADHD) ,Brain Disorders ,Mental Health ,Mental health ,Good Health and Well Being ,Adolescent ,Adult ,Alcohol Drinking ,Attention Deficit Disorder with Hyperactivity ,Canada ,Child ,Cigarette Smoking ,Female ,Humans ,Longitudinal Studies ,Male ,Marijuana Use ,Substance-Related Disorders ,United States ,Young Adult ,Attention deficit disorder ,ADHD ,drug abuse ,adolescence ,Clinical Sciences ,Psychology ,Cognitive Sciences ,Developmental & Child Psychology ,Clinical sciences ,Applied and developmental psychology ,Clinical and health psychology - Abstract
BACKGROUND:Inconsistent findings exist regarding long-term substance use (SU) risk for children diagnosed with attention-deficit/hyperactivity disorder (ADHD). The observational follow-up of the Multimodal Treatment Study of Children with ADHD (MTA) provides an opportunity to assess long-term outcomes in a large, diverse sample. METHODS:Five hundred forty-seven children, mean age 8.5, diagnosed with DSM-IV combined-type ADHD and 258 classmates without ADHD (local normative comparison group; LNCG) completed the Substance Use Questionnaire up to eight times from mean age 10 to mean age 25. RESULTS:In adulthood, weekly marijuana use (32.8% ADHD vs. 21.3% LNCG) and daily cigarette smoking (35.9% vs. 17.5%) were more prevalent in the ADHD group than the LNCG. The cumulative record also revealed more early substance users in adolescence for ADHD (57.9%) than LNCG (41.9%), including younger first use of alcohol, cigarettes, marijuana, and illicit drugs. Alcohol and nonmarijuana illicit drug use escalated slightly faster in the ADHD group in early adolescence. Early SU predicted quicker SU escalation and more SU in adulthood for both groups. CONCLUSIONS:Frequent SU for young adults with childhood ADHD is accompanied by greater initial exposure at a young age and slightly faster progression. Early SU prevention and screening is critical before escalation to intractable levels.
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- 2018
31. Parental Care and Binge-Eating Disorder
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Amianto, Federico, primary and Vitiello, Benedetto, additional
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- 2022
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32. Suicide in the press: An analysis of newspaper coverage of adolescent versus adult suicides in Italy
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Davico, Chiara, primary, Arletti, Luca, additional, Silverio, Giulia, additional, Marcotulli, Daniele, additional, Ricci, Federica S., additional, Amianto, Federico, additional, and Vitiello, Benedetto, additional
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- 2024
- Full Text
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33. The World Federation of ADHD International Consensus Statement: 208 Evidence-based conclusions about the disorder
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Faraone, Stephen V., Banaschewski, Tobias, Coghill, David, Zheng, Yi, Biederman, Joseph, Bellgrove, Mark A., Newcorn, Jeffrey H., Gignac, Martin, Al Saud, Nouf M., Manor, Iris, Rohde, Luis Augusto, Yang, Li, Cortese, Samuele, Almagor, Doron, Stein, Mark A., Albatti, Turki H., Aljoudi, Haya F., Alqahtani, Mohammed M.J., Asherson, Philip, Atwoli, Lukoye, Bölte, Sven, Buitelaar, Jan K., Crunelle, Cleo L., Daley, David, Dalsgaard, Søren, Döpfner, Manfred, Espinet (on behalf of CADDRA), Stacey, Fitzgerald, Michael, Franke, Barbara, Gerlach, Manfred, Haavik, Jan, Hartman, Catharina A., Hartung, Cynthia M., Hinshaw, Stephen P., Hoekstra, Pieter J., Hollis, Chris, Kollins, Scott H., Sandra Kooij, J.J., Kuntsi, Jonna, Larsson, Henrik, Li, Tingyu, Liu, Jing, Merzon, Eugene, Mattingly, Gregory, Mattos, Paulo, McCarthy, Suzanne, Mikami, Amori Yee, Molina, Brooke S.G., Nigg, Joel T., Purper-Ouakil, Diane, Omigbodun, Olayinka O., Polanczyk, Guilherme V., Pollak, Yehuda, Poulton, Alison S., Rajkumar, Ravi Philip, Reding, Andrew, Reif, Andreas, Rubia, Katya, Rucklidge, Julia, Romanos, Marcel, Ramos-Quiroga, J. Antoni, Schellekens, Arnt, Scheres, Anouk, Schoeman, Renata, Schweitzer, Julie B., Shah, Henal, Solanto, Mary V., Sonuga-Barke, Edmund, Soutullo, César, Steinhausen, Hans-Christoph, Swanson, James M., Thapar, Anita, Tripp, Gail, van de Glind, Geurt, van den Brink, Wim, Van der Oord, Saskia, Venter, Andre, Vitiello, Benedetto, Walitza, Susanne, and Wang, Yufeng
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- 2021
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34. The pediatric psychopharmacology of autism spectrum disorder: A systematic review - Part I: The past and the present
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Persico, Antonio M., Ricciardello, Arianna, Lamberti, Marco, Turriziani, Laura, Cucinotta, Francesca, Brogna, Claudia, Vitiello, Benedetto, and Arango, Celso
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- 2021
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35. Childhood Predictors of Adult Functional Outcomes in the Multimodal Treatment Study of Attention-Deficit/Hyperactivity Disorder (MTA)
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Roy, Arunima, Hechtman, Lily, Arnold, L Eugene, Swanson, James M, Molina, Brooke SG, Sibley, Margaret H, Howard, Andrea L, Group, MTA Cooperative, Vitiello, Benedetto, Severe, Joanne B, Jensen, Peter S, Hoagwood, Kimberly, Richters, John, Vereen, Donald, Hinshaw, Stephen P, Elliott, Glen R, Wells, Karen C, Epstein, Jeffery N, Murray, Desiree W, Conners, C Keith, March, John, Swanson, James, Wigal, Timothy, Cantwell, Dennis P, Abikoff, Howard B, Greenhill, Laurence L, Newcorn, Jeffrey H, Molina, Brooke, Hoza, Betsy, Pelham, William E, Gibbons, Robert D, Marcus, Sue, Hur, Kwan, Kraemer, Helena C, Hanley, Thomas, and Stern, Karen
- Subjects
Clinical and Health Psychology ,Psychology ,Prevention ,Brain Disorders ,Pediatric ,Behavioral and Social Science ,Pediatric Research Initiative ,Clinical Research ,Mental Health ,Attention Deficit Hyperactivity Disorder (ADHD) ,2.3 Psychological ,social and economic factors ,Aetiology ,Quality Education ,Adolescent ,Adult ,Attention Deficit Disorder with Hyperactivity ,Child ,Educational Status ,Emotions ,Employment ,Family ,Female ,Follow-Up Studies ,Humans ,Income ,Intelligence ,Male ,Young Adult ,attention-deficit/hyperactivity disorder ,adult outcomes ,functioning ,Multimodal Treatment Study of ADHD study ,childhood predictors ,MTA Cooperative Group ,Medical and Health Sciences ,Psychology and Cognitive Sciences ,Developmental & Child Psychology ,Clinical sciences ,Paediatrics ,Applied and developmental psychology - Abstract
ObjectiveRecent results from the Multimodal Treatment Study of Attention-Deficit/Hyperactivity Disorder (ADHD; MTA) have demonstrated impairments in several functioning domains in adults with childhood ADHD. The childhood predictors of these adult functional outcomes are not adequately understood. The objective of the present study was to determine the effects of childhood demographic, clinical, and family factors on adult functional outcomes in individuals with and without childhood ADHD from the MTA cohort.MethodRegressions were used to determine associations of childhood factors (age range 7-10 years) of family income, IQ, comorbidity (internalizing, externalizing, and total number of non-ADHD diagnoses), parenting styles, parental education, number of household members, parental marital problems, parent-child relationships, and ADHD symptom severity with adult outcomes (mean age 25 years) of occupational functioning, educational attainment, emotional functioning, sexual behavior, and justice involvement in participants with (n = 579) and without (n = 258) ADHD.ResultsPredictors of adult functional outcomes in ADHD included clinical factors such as baseline ADHD severity, IQ, and comorbidity; demographic factors such as family income, number of household members and parental education; and family factors such as parental monitoring and parental marital problems. Predictors of adult outcomes were generally comparable for children with and without ADHD.ConclusionChildhood ADHD symptoms, IQ, and household income levels are important predictors of adult functional outcomes. Management of these areas early on, through timely treatments for ADHD symptoms, and providing additional support to children with lower IQ and from households with low incomes, could assist in improving adult functioning.
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- 2017
36. Young adult outcomes in the follow‐up of the multimodal treatment study of attention‐deficit/hyperactivity disorder: symptom persistence, source discrepancy, and height suppression
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Swanson, James M, Arnold, L Eugene, Molina, Brooke SG, Sibley, Margaret H, Hechtman, Lily T, Hinshaw, Stephen P, Abikoff, Howard B, Stehli, Annamarie, Owens, Elizabeth B, Mitchell, John T, Nichols, Quyen, Howard, Andrea, Greenhill, Laurence L, Hoza, Betsy, Newcorn, Jeffrey H, Jensen, Peter S, Vitiello, Benedetto, Wigal, Timothy, Epstein, Jeffery N, Tamm, Leanne, Lakes, Kimberly D, Waxmonsky, James, Lerner, Marc, Etcovitch, Joy, Murray, Desiree W, Muenke, Maximilian, Acosta, Maria T, Arcos‐Burgos, Mauricio, Pelham, William E, Kraemer, Helena C, and Group, the MTA Cooperative
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Clinical and Health Psychology ,Biomedical and Clinical Sciences ,Psychology ,Brain Disorders ,Mental Health ,Clinical Research ,Pediatric ,Attention Deficit Hyperactivity Disorder (ADHD) ,Clinical Trials and Supportive Activities ,Adolescent ,Adult ,Aftercare ,Attention Deficit Disorder with Hyperactivity ,Body Height ,Child ,Combined Modality Therapy ,Female ,Follow-Up Studies ,Humans ,Male ,Outcome Assessment ,Health Care ,Severity of Illness Index ,Young Adult ,Attention-deficit ,hyperactivity disorder ,follow-up studies ,growth ,longitudinal studies ,treatment trials ,medication effects ,MTA Cooperative Group ,Attention-deficit/hyperactivity disorder ,Clinical Sciences ,Cognitive Sciences ,Developmental & Child Psychology ,Clinical sciences ,Applied and developmental psychology ,Clinical and health psychology - Abstract
BackgroundThe Multimodal Treatment Study (MTA) began as a 14-month randomized clinical trial of behavioral and pharmacological treatments of 579 children (7-10 years of age) diagnosed with attention-deficit/hyperactivity disorder (ADHD)-combined type. It transitioned into an observational long-term follow-up of 515 cases consented for continuation and 289 classmates (258 without ADHD) added as a local normative comparison group (LNCG), with assessments 2-16 years after baseline.MethodsPrimary (symptom severity) and secondary (adult height) outcomes in adulthood were specified. Treatment was monitored to age 18, and naturalistic subgroups were formed based on three patterns of long-term use of stimulant medication (Consistent, Inconsistent, and Negligible). For the follow-up, hypothesis-generating analyses were performed on outcomes in early adulthood (at 25 years of age). Planned comparisons were used to estimate ADHD-LNCG differences reflecting persistence of symptoms and naturalistic subgroup differences reflecting benefit (symptom reduction) and cost (height suppression) associated with extended use of medication.ResultsFor ratings of symptom severity, the ADHD-LNCG comparison was statistically significant for the parent/self-report average (0.51 ± 0.04, p
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- 2017
37. The song of Anorexia Nervosa: a specific evoked potential response to musical stimuli in affected participants
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Spalatro, Angela Valentina, Marzolla, Marco, Vighetti, Sergio, Daga, Giovanni Abbate, Fassino, Secondo, Vitiello, Benedetto, and Amianto, Federico
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- 2021
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38. Functional Adult Outcomes 16 Years After Childhood Diagnosis of Attention-Deficit/Hyperactivity Disorder: MTA Results
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Hechtman, Lily, Swanson, James M, Sibley, Margaret H, Stehli, Annamarie, Owens, Elizabeth B, Mitchell, John T, Arnold, L Eugene, Molina, Brooke SG, Hinshaw, Stephen P, Jensen, Peter S, Abikoff, Howard B, Algorta, Guillermo Perez, Howard, Andrea L, Hoza, Betsy, Etcovitch, Joy, Houssais, Sylviane, Lakes, Kimberley D, Nichols, J Quyen, Group, MTA Cooperative, Vitiello, Benedetto, Severe, Joanne B, Hoagwood, Kimberly, Richters, John, Vereen, Donald, Elliott, Glen R, Wells, Karen C, Epstein, Jeffery N, Murray, Desiree W, Conners, C Keith, March, John, Swanson, James, Wigal, Timothy, Cantwell, Dennis P, Greenhill, Laurence L, Newcorn, Jeffrey H, Molina, Brooke, Pelham, William E, Gibbons, Robert D, Marcus, Sue, Hur, Kwan, Kraemer, Helena C, Hanley, Thomas, and Stern, Karen
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Clinical and Health Psychology ,Psychology ,Clinical Research ,Brain Disorders ,Attention Deficit Hyperactivity Disorder (ADHD) ,Substance Misuse ,Pediatric ,Mental Health ,Behavioral and Social Science ,Aetiology ,2.3 Psychological ,social and economic factors ,Mental health ,Good Health and Well Being ,Adolescent ,Adult ,Aftercare ,Attention Deficit Disorder with Hyperactivity ,Child ,Disease Progression ,Employment ,Female ,Humans ,Male ,Substance-Related Disorders ,Young Adult ,ADHD ,adult outcomes ,follow-up ,MTA ,functional outcomes ,MTA Cooperative Group ,Medical and Health Sciences ,Psychology and Cognitive Sciences ,Developmental & Child Psychology ,Clinical sciences ,Paediatrics ,Applied and developmental psychology - Abstract
ObjectiveTo compare educational, occupational, legal, emotional, substance use disorder, and sexual behavior outcomes in young adults with persistent and desistent attention-deficit/hyperactivity disorder (ADHD) symptoms and a local normative comparison group (LNCG) in the Multimodal Treatment Study of Children with ADHD (MTA).MethodData were collected 12, 14, and 16 years postbaseline (mean age 24.7 years at 16 years postbaseline) from 476 participants with ADHD diagnosed at age 7 to 9 years, and 241 age- and sex-matched classmates. Probands were subgrouped on persistence versus desistence of DSM-5 symptom count. Orthogonal comparisons contrasted ADHD versus LNCG and symptom-persistent (50%) versus symptom-desistent (50%) subgroups. Functional outcomes were measured with standardized and demographic instruments.ResultsThree patterns of functional outcomes emerged. Post-secondary education, times fired/quit a job, current income, receiving public assistance, and risky sexual behavior showed the most common pattern: the LNCG group fared best, symptom-persistent ADHD group worst, and symptom-desistent ADHD group between, with the largest effect sizes between LNCG and symptom-persistent ADHD. In the second pattern, seen with emotional outcomes (emotional lability, neuroticism, anxiety disorder, mood disorder) and substance use outcomes, the LNCG and symptom-desistent ADHD group did not differ, but both fared better than the symptom-persistent ADHD group. In the third pattern, noted with jail time (rare), alcohol use disorder (common), and number of jobs held, group differences were not significant. The ADHD group had 10 deaths compared to one death in the LNCG.ConclusionAdult functioning after childhood ADHD varies by domain and is generally worse when ADHD symptoms persist. It is important to identify factors and interventions that promote better functional outcomes.
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- 2016
39. Childhood Factors Affecting Persistence and Desistence of Attention-Deficit/Hyperactivity Disorder Symptoms in Adulthood: Results From the MTA
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Roy, Arunima, Hechtman, Lily, Arnold, L Eugene, Sibley, Margaret H, Molina, Brooke SG, Swanson, James M, Howard, Andrea L, Group, MTA Cooperative, Vitiello, Benedetto, Severe, Joanne B, Jensen, Peter S, Hoagwood, Kimberly, Richters, John, Vereen, Donald, Hinshaw, Stephen P, Elliott, Glen R, Wells, Karen C, Epstein, Jeffery N, Murray, Desiree W, Conners, C Keith, March, John, Swanson, James, Wigal, Timothy, Cantwell, Dennis P, Abikoff, Howard B, Greenhill, Laurence L, Newcorn, Jeffrey H, Molina, Brooke, Hoza, Betsy, Pelham, William E, Gibbons, Robert D, Marcus, Sue, Hur, Kwan, Kraemer, Helena C, Hanley, Thomas, and Stern, Karen
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Clinical and Health Psychology ,Psychology ,Brain Disorders ,Mental Health ,Prevention ,Attention Deficit Hyperactivity Disorder (ADHD) ,Pediatric ,Clinical Research ,Behavioral and Social Science ,Pediatric Research Initiative ,2.3 Psychological ,social and economic factors ,Aetiology ,Mental health ,Good Health and Well Being ,Adult ,Attention Deficit Disorder with Hyperactivity ,Child ,Child of Impaired Parents ,Disease Progression ,Female ,Follow-Up Studies ,Humans ,Male ,Mental Disorders ,Parents ,Severity of Illness Index ,attention-deficit/hyperactivity disorder ,adulthood ,family ,comorbidity ,IQ ,MTA Cooperative Group ,Medical and Health Sciences ,Psychology and Cognitive Sciences ,Developmental & Child Psychology ,Clinical sciences ,Paediatrics ,Applied and developmental psychology - Abstract
ObjectiveTo determine childhood factors that predict attention-deficit/hyperactivity disorder (ADHD) persistence and desistence in adulthood.MethodRegression analyses were used to determine associations between childhood factors and adult ADHD symptom persistence in 453 participants (mean age, 25 years) from the Multimodal Treatment Study of Children with ADHD (MTA). Childhood IQ, total number of comorbidities, child-perceived parenting practices, child-perceived parent-child relationships, parental mental health problems, marital problems of parents, household income levels, and parental education were assessed at a mean age of 8 years in all participants. Adult ADHD persistence was defined using DSM-5 symptom counts either with or without impairment, as well as mean ADHD symptom scores on the Conners' Adult ADHD Rating Scale (CAARS). Age, sex, MTA site, and childhood ADHD symptoms were covaried.ResultsThe most important childhood predictors of adult ADHD symptom persistence were initial ADHD symptom severity (odds ratio [OR] = 1.89, standard error [SE] = 0.28, p = .025), comorbidities (OR = 1.19, SE = 0.07, p = .018), and parental mental health problems (OR = 1.30, SE = 0.09, p = .003). Childhood IQ, socioeconomic status, parental education, and parent-child relationships showed no associations with adult ADHD symptom persistence.ConclusionInitial ADHD symptom severity, parental mental health, and childhood comorbidity affect persistence of ADHD symptoms into adulthood. Addressing these areas early may assist in reducing adult ADHD persistence and functioning problems.
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- 2016
40. Gender Differences in Treatment-Seeking Youth with Autism Spectrum Disorder
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Cariveau, Tom, McCracken, Courtney E., Bradshaw, Jessica, Postorino, Valentina, Shillingsburg, M. Alice, McDougle, Christopher J., Aman, Michael G., McCracken, James T., Tierney, Elaine, Johnson, Cynthia, Lecavalier, Luc, Smith, Tristram, Swiezy, Naomi B., King, Bryan H., Hollander, Eric, Sikich, Linmarie, Vitiello, Benedetto, and Scahill, Lawrence
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- 2021
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41. Psychopharmacology in children and adolescents: unmet needs and opportunities
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Cortese, Samuele, primary, Purper-Ouakil, Diane, additional, Apter, Alan, additional, Arango, Celso, additional, Baeza, Inmaculada, additional, Banaschewski, Tobias, additional, Buitelaar, Jan, additional, Castro-Fornieles, Josefina, additional, Coghill, David, additional, Cohen, David, additional, Correll, Christoph U, additional, Grünblatt, Edna, additional, Hoekstra, Pieter J, additional, James, Anthony, additional, Jeppesen, Pia, additional, Nagy, Péter, additional, Pagsberg, Anne Katrine, additional, Parellada, Mara, additional, Persico, Antonio M, additional, Roessner, Veit, additional, Santosh, Paramala, additional, Simonoff, Emily, additional, Stevanovic, Dejan, additional, Stringaris, Argyris, additional, Vitiello, Benedetto, additional, Walitza, Susanne, additional, Weizman, Abraham, additional, Wong, Ian C K, additional, Zalsman, Gil, additional, Zuddas, Alessandro, additional, Carucci, Sara, additional, Butlen-Ducuing, Florence, additional, Tome, Maria, additional, Bea, Myriam, additional, Getin, Christine, additional, Hovén, Nina, additional, Konradsson-Geuken, Asa, additional, Lamirell, Daphne, additional, Olisa, Nigel, additional, Nafria Escalera, Begonya, additional, and Moreno, Carmen, additional
- Published
- 2023
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42. Is prevention of ADHD and comorbid conditions in adolescents possible?
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Vitiello, Benedetto, primary, Davico, Chiara, additional, and Döpfner, Manfred, additional
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- 2023
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43. Dr. Johnstone et al. Reply to Dr. Hamilton
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Johnstone, Jeanette M., primary, Srikanth, Priya, additional, Robinette, Lisa M., additional, Bruton, Alisha M., additional, Leung, Brenda M.Y., additional, Gracious, Barbara L., additional, Hatsu, Irene E., additional, Vitiello, Benedetto, additional, and Arnold, L. Eugene, additional
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- 2023
- Full Text
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44. Clinical and personality characteristics of adolescents with anorexia nervosa with or without non-suicidal self-injurious behavior
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Davico, Chiara, Amianto, Federico, Gaiotti, Federica, Lasorsa, Claudia, Peloso, Anna, Bosia, Chiara, Vesco, Serena, Arletti, Luca, Reale, Laura, and Vitiello, Benedetto
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- 2019
- Full Text
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45. Psychopathology and Adaptive Functioning in Children, Adolescents, and Young Adults with Noonan Syndrome
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Davico, Chiara, Borgogno, Marta, Campagna, Filippa, DʼAlessandro, Rossella, Ricci, Federica, Amianto, Federico, Mussa, Alessandro, Carli, Diana, Ferrero, Giovanni Battista, and Vitiello, Benedetto
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- 2022
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46. Children’s Global Assessment Scale
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Vitiello, Benedetto, primary
- Published
- 2021
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47. Pharmacotherapy of the Preschool ADHD Treatment Study (PATS) Children Growing Up
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Vitiello, Benedetto, Lazzaretto, Deborah, Yershova, Kseniya, Abikoff, Howard, Paykina, Natalya, McCracken, James T, McGough, James J, Kollins, Scott H, Greenhill, Laurence L, Wigal, Sharon, Wigal, Tim, and Riddle, Mark A
- Subjects
Biological Psychology ,Biomedical and Clinical Sciences ,Psychology ,Brain Disorders ,Pediatric ,Clinical Research ,Mental Health ,Attention Deficit Hyperactivity Disorder (ADHD) ,Clinical Trials and Supportive Activities ,Evaluation of treatments and therapeutic interventions ,6.1 Pharmaceuticals ,Antipsychotic Agents ,Atomoxetine Hydrochloride ,Attention Deficit Disorder with Hyperactivity ,Central Nervous System Stimulants ,Child ,Child ,Preschool ,Comorbidity ,Female ,Follow-Up Studies ,Humans ,Logistic Models ,Male ,Methylphenidate ,Prospective Studies ,Psychiatric Status Rating Scales ,Treatment Outcome ,ADHD ,preschoolers ,medication ,stimulant ,Medical and Health Sciences ,Psychology and Cognitive Sciences ,Developmental & Child Psychology ,Clinical sciences ,Paediatrics ,Applied and developmental psychology - Abstract
ObjectiveTo describe the long-term psychopharmacological treatment of children first diagnosed with attention-deficit/hyperactivity disorder (ADHD) as preschoolers.MethodIn a systematic, prospective, naturalistic follow-up, 206 (68.0%) of the 303 children who participated in the Preschool ADHD Treatment Study (PATS) were reassessed 3 years (mean age 7.4 years) and 179 (59.1%) were reassessed 6 years (mean age 10.4 years) after completion of the controlled study. Pharmacotherapy and clinical data were obtained from the parents. Pharmacotherapy was defined as use of a specific class of medication for at least 50% of the days in the previous 6 months.ResultsAt year 3, a total of 34.0% of the participants were on no pharmacotherapy, 41.3% were on stimulant monotherapy, 9.2% were on atomoxetine alone or with a stimulant, 8.3% were on an antipsychotic usually together with a stimulant, and the remaining 7.2% were on other pharmacotherapy; overall, 65.0% were on an indicated ADHD medication. At year 6, a total of 26.8% of the participants were on no pharmacotherapy, 40.2% were on stimulant monotherapy, 4.5% were on atomoxetine alone or with a stimulant, 13.4% were on an antipsychotic, and 15.1% were on other pharmacotherapy; overall, 70.9% were on an indicated ADHD medication. Antipsychotic treatment was associated with more comorbidity, in particular disruptive behavior disorders and pervasive development disorders, and a lower level of functioning.ConclusionIn this study, the long-term pharmacotherapy of preschoolers with ADHD was heterogeneous. Although stimulant medication continued to be used by most children, about 1 child in 4 was off medication, and about 1 in 10 was on an antipsychotic.
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- 2015
48. Overweight and Obese Status in Children with Autism Spectrum Disorder and Disruptive Behavior
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Criado, Kristen K., Sharp, William G., McCracken, Courtney E., De Vinck-Baroody, Oana, Dong, Liansai, Aman, Michael G., McDougle, Christopher J., McCracken, James T., Eugene Arnold, L., Weitzman, Carol, Leventhal, John M., Vitiello, Benedetto, and Scahill, Lawrence
- Abstract
Overweight and obesity are common in pediatric populations. Children with autism spectrum disorder and disruptive behavior may be at higher risk. This study examined whether children with autism spectrum disorder and disruptive behavior are more likely to be overweight or obese than matched controls. Baseline data from medication-free children with autism spectrum disorder who participated in trials conducted by the Research Units on Pediatric Psychopharmacology Autism Network (N = 276) were compared to 544 control children from the National Health and Nutrition Examination Survey database matched on age, sex, race, parent education, and era of data collection. The mean age of the children with autism spectrum disorder was 7.9 ± 2.6 years; 84.4% were males. In the autism spectrum disorder group, the prevalence was 42.4% for overweight and 21.4% for obesity compared to 26.1% for overweight and 12.0% for obesity among controls (p < 0.001 for each contrast). Within the autism spectrum disorder sample, obesity was associated with minority status and lower daily living skills. These findings suggest that children with autism spectrum disorder and disruptive behavior are at increased risk for obesity and underscore the need for weight management interventions in this population.
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- 2018
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49. Children's Yale–Brown Obsessive Compulsive Scale in Autism Spectrum Disorder: Component Structure and Correlates of Symptom Checklist
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Scahill, Lawrence, Dimitropoulos, Anastasia, McDougle, Christopher J, Aman, Michael G, Feurer, Irene D, McCracken, James T, Tierney, Elaine, Pu, Jie, White, Susan, Lecavalier, Luc, Hallett, Victoria, Bearss, Karen, King, Bryan, Arnold, L Eugene, and Vitiello, Benedetto
- Subjects
Intellectual and Developmental Disabilities (IDD) ,Brain Disorders ,Autism ,Mental Health ,Pediatric ,Clinical Research ,Pediatric Research Initiative ,Mental health ,Adolescent ,Checklist ,Child ,Child Development Disorders ,Pervasive ,Child ,Preschool ,Female ,Humans ,Male ,Obsessive-Compulsive Disorder ,Psychiatric Status Rating Scales ,Psychometrics ,Randomized Controlled Trials as Topic ,autism spectrum disorder ,clinical trials ,outcome measures ,repetitive behavior ,Medical and Health Sciences ,Psychology and Cognitive Sciences ,Developmental & Child Psychology - Abstract
ObjectiveRepetitive behaviors in autism spectrum disorders (ASD) range from motor stereotypy to immersion in restricted interests. The modified Children's Yale-Brown Obsessive Compulsive Scale for children with autism spectrum disorder (CYBOCS-ASD) includes a Symptom Checklist (behavior present or absent) and 5 severity scales (Time Spent, Interference, Distress, Resistance and Control).MethodWe assembled CYBOCS-ASD data from 3 Research Units on Pediatric Psychopharmacology Autism Network trials to explore the component structure of repetitive behaviors in children with ASD. Raters trained to reliability conducted the CYBOCS-ASD in 272 medication-free subjects. Fifteen Symptom Checklist items were endorsed for less than 5% of the sample and were dropped. Principal component analysis was used to explore the clustering of 23 checklist items. Component scores computed for each subject were correlated with other measures. We also examined the distribution of severity scales.ResultsThe subjects (229 boys and 43 girls; mean age = 7.8 ± 2.6 years) met criteria for an ASD; half were intellectually disabled. The PCA resulted in a 5-component solution to classify repetitive behaviors (34.4% of the variance): hoarding and ritualistic behavior; sensory and arranging behavior; sameness and self-injurious behavior; stereotypy; restricted interests. Sensory and arranging and stereotypy components were associated with lower adaptive functioning (Pearson r = 0.2-0.3; p < .003). The resistance scale showed little variation, with more than 60% of the sample with the highest score.ConclusionsRarely endorsed items can be dropped from the Checklist. The resistance item does not appear to be relevant for children with ASD.
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- 2014
50. Is prevention of ADHD and comorbid conditions in adolescents possible?
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Vitiello, Benedetto, Davico, Chiara, and Döpfner, Manfred
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ATTENTION-deficit hyperactivity disorder ,TEENAGERS ,TRAFFIC safety ,COGNITIVE training ,COMORBIDITY - Abstract
Objectives: To examine how the concept of prevention is applicable to adolescent ADHD, which preventive interventions may be feasible, and which methods can be used to evaluate effectiveness. Method: Following a literature search for prevention clinical trials relevant to adolescent ADHD, selected studies are critically reviewed to identify suitable targets and promising interventions. Results: There is some evidence from controlled studies that interventions delivered to prepubertal children at high risk for ADHD or diagnosed with ADHD may decrease the incidence or persistence of ADHD in adolescence. Uncontrolled follow-up of clinical samples and population studies suggest that treatment of adolescents with ADHD can decrease the risk for several negative functional outcomes in youth. A controlled trial found a specific cognitive training intervention to decrease risky driving. Conclusions: Prevention of ADHD and associated negative outcomes is possible and of high clinical relevance. Assessing prevention effects is methodologically challenging, but feasible. [ABSTRACT FROM AUTHOR]
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- 2024
- Full Text
- View/download PDF
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