210 results on '"Vitcu, A."'
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2. LA GENESE DU PROGRAMME UNIONISTE : « LA SOCIÉTÉ DE L’UNION » DE YASSY (1856)
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Dumitru VITCU
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les principautés roumaines ,le congrès de paris (1856) ,« la société de l’union » de yassy ,m. kogălniceanu ,v. alecsandri ,c. negri ,c. hurmuzachi ,v. mălinescu ,des divans ad-hoc ,la convention de paris (1858) ,History (General) ,D1-2009 - Abstract
Dans le processus ample et complexe de la lutte pour l’achèvement de l’État national roumain moderne, l’ancienne capitale de Moldavie (la ville de Yassy) a joué un rôle décisif, signalé pour la première fois par le grand historien A. D. Xenopol. Un aspect significatif et en même temps un argument dans ce sens sont offerts par ce texte consacré à l’organisation de la lutte pour l’unité nationale dans les Principautés Roumaines, immédiatement après la clôture du Congrès de Paris (1856), qui pacifiait pour une période l’éternelle « question orientale ». Mais, ce que le conclave diplomatique européen n’a pas réussi – l’unité nationale roumaine – allait être achevé par les Roumains même, tout en affirmant clairement les droits et les objectifs nationaux, ainsi que les moyens de leur accomplissement. Le fondement de tout effort patriotique a été représenté à ce momentlà par « la Société de l’Union » de Yassy, organisée le 25 mai 1856 et composée des leaders unionistes moldaves : M. Kogălniceanu, V. Alecsandri, C. Negri, C. Hurmuzachi, V. Mălinescu etc., qui ont formulé et distribué, dans l’espace roumain extra-carpatique entier, les lignes directrices du programme national. Les deux Assemblées consultatives (des Divans ad-hoc) de Bucarest et Yassy les ont reprises et appropriées en intégralité pour les transmettre ultérieurement aux Puissances européennes garantes, qui ont élaboré – sur leur base – l’éphémère Constitution pour les Principautés Unies, la Convention de Paris (1858).
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- 2022
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3. Post-Severe-COVID-19 Cardiopulmonary Rehabilitation: A Comprehensive Study on Patient Features and Recovery Dynamics in Correlation with Workout Intensity
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Andreea Dumitrescu, Gabriela Doros, Voichita Elena Lazureanu, Susa Septimiu-Radu, Felix Bratosin, Ovidiu Rosca, Harshkumar Patel, Tamara Mirela Porosnicu, Gabriela Mut Vitcu, Andrei Mirea, Cristian Oancea, Stefan Mihaicuta, Emil Robert Stoicescu, and Paula Irina Barata
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COVID-19 ,SARS-CoV-2 ,post acute COVID-19 syndrome ,cardiopulmonary rehabilitation ,Medicine - Abstract
The aftermath of severe COVID-19 frequently involves considerable cardiopulmonary damage, necessitating rehabilitation. This study aimed to evaluate the impact of COVID-19 on cardiopulmonary health and assess the effectiveness of various rehabilitative interventions. Conducted between September 2021 and September 2022, this prospective study included patients who had been diagnosed with severe COVID-19 and admitted at the “Victor Babes” Infectious Diseases and Pulmonology Hospital, Timisoara, Romania. The patients were stratified into low- and high-intensity rehabilitation groups. The rehabilitation protocols were individually tailored, and the patient recovery was closely monitored over a 3-month period. Our cohort comprised 84 patients, with a mean age of 56.3 years for the low-intensity group (n = 42) and 53.1 years for the high-intensity group (n = 42). Both groups showed significant improvements in the lung injury area, need for oxygen supplementation, ejection fraction, systolic pulmonary artery pressure, and forced vital capacity. Additionally, considerable enhancements were observed in maximal voluntary ventilation, FEV1, FEV1/FVC ratio, peak expiratory flow, and forced expiratory flow at 25–75%. The work intensity also demonstrated substantial improvements from the initial testing to the 3-month mark in both groups. This study provides evidence that personalized, targeted rehabilitation strategies can improve long-term cardiopulmonary health in patients recovering from severe COVID-19, proving both low-intensity and high-intensity training as sufficient to improve heart and lung function if performed correctly and over a relatively short duration of 3 months. The study findings underscore the importance of implementing comprehensive cardiopulmonary rehabilitation protocols in the care of post-COVID-19 patients and highlight the value of stratified rehabilitation intensity based on individual patient dynamics and recovery features.
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- 2023
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4. Post-Severe-COVID-19 Cardiopulmonary Rehabilitation: A Comprehensive Study on Patient Features and Recovery Dynamics in Correlation with Workout Intensity
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Dumitrescu, Andreea, primary, Doros, Gabriela, additional, Lazureanu, Voichita Elena, additional, Septimiu-Radu, Susa, additional, Bratosin, Felix, additional, Rosca, Ovidiu, additional, Patel, Harshkumar, additional, Porosnicu, Tamara Mirela, additional, Vitcu, Gabriela Mut, additional, Mirea, Andrei, additional, Oancea, Cristian, additional, Mihaicuta, Stefan, additional, Stoicescu, Emil Robert, additional, and Barata, Paula Irina, additional
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- 2023
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5. Post-Severe-COVID-19 Cardiopulmonary Rehabilitation: A Comprehensive Study on Patient Features and Recovery Dynamics in Correlation with Workout Intensity
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Barata, Andreea Dumitrescu, Gabriela Doros, Voichita Elena Lazureanu, Susa Septimiu-Radu, Felix Bratosin, Ovidiu Rosca, Harshkumar Patel, Tamara Mirela Porosnicu, Gabriela Mut Vitcu, Andrei Mirea, Cristian Oancea, Stefan Mihaicuta, Emil Robert Stoicescu, and Paula Irina
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COVID-19 ,SARS-CoV-2 ,post acute COVID-19 syndrome ,cardiopulmonary rehabilitation - Abstract
The aftermath of severe COVID-19 frequently involves considerable cardiopulmonary damage, necessitating rehabilitation. This study aimed to evaluate the impact of COVID-19 on cardiopulmonary health and assess the effectiveness of various rehabilitative interventions. Conducted between September 2021 and September 2022, this prospective study included patients who had been diagnosed with severe COVID-19 and admitted at the “Victor Babes” Infectious Diseases and Pulmonology Hospital, Timisoara, Romania. The patients were stratified into low- and high-intensity rehabilitation groups. The rehabilitation protocols were individually tailored, and the patient recovery was closely monitored over a 3-month period. Our cohort comprised 84 patients, with a mean age of 56.3 years for the low-intensity group (n = 42) and 53.1 years for the high-intensity group (n = 42). Both groups showed significant improvements in the lung injury area, need for oxygen supplementation, ejection fraction, systolic pulmonary artery pressure, and forced vital capacity. Additionally, considerable enhancements were observed in maximal voluntary ventilation, FEV1, FEV1/FVC ratio, peak expiratory flow, and forced expiratory flow at 25–75%. The work intensity also demonstrated substantial improvements from the initial testing to the 3-month mark in both groups. This study provides evidence that personalized, targeted rehabilitation strategies can improve long-term cardiopulmonary health in patients recovering from severe COVID-19, proving both low-intensity and high-intensity training as sufficient to improve heart and lung function if performed correctly and over a relatively short duration of 3 months. The study findings underscore the importance of implementing comprehensive cardiopulmonary rehabilitation protocols in the care of post-COVID-19 patients and highlight the value of stratified rehabilitation intensity based on individual patient dynamics and recovery features.
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- 2023
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6. Depression influences the quality of diabetes-related self-management activities in elderly patients with type 2 diabetes: a cross-sectional study
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Mut-Vitcu G, Timar B, Timar R, Oancea C, and Citu IC
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Diabetes ,Depression ,Self-care ,Quality of life ,Geriatrics ,RC952-954.6 - Abstract
Gabriela Mut-Vitcu,1 Bogdan Timar,2 Romulus Timar,1 Cristian Oancea,3 Ioan Cosmin Citu4 1Second Department of Internal Medicine, 2Department of Functional Sciences, 3Department of Infectious Diseases, 4Department of Obstetrics and Gynecology, “Victor Babes” University of Medicine and Pharmacy, Timisoara, Romania Purpose: To evaluate the prevalence of depression and its impact on the quality of diabetes-related self-care activities in elderly patients with type 2 diabetes. Patients and methods: In this cross-sectional study, 184 patients with type 2 diabetes were enrolled. Depression was evaluated using Patient Health Questionnaire-9 while the quality of diabetes-related self-care activities was assessed using the Summary of Diabetes-Related Self Care Activities Questionnaire. Results: In our study group, 53.3% of the patients had moderate depression, 17.9% had severe depression, and 28.8% had no depression symptoms. Patient’s age (P=0.024), presence of diabetic neuropathy (P
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- 2016
7. 'La question juive' dans les relations externes de la Roumanie à la fin du XIX-ème siècle
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Dumitru Vitcu
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La Roumanie ,la politique externe ,les Juifs ,les minorités ethniques ,l’Alliance Israélite Universelle ,la diplomatie ,la discrimination ethnique ,le gouvernement roumain ,le secrétaire d’Etat ,le ministre des Affaires Etrangères ,History (General) ,D1-2009 - Abstract
The first Romanian modern Constitution of 1866 generated – by its restrictive character towards the political and civil rights of the non-Christian citizens in the country – a problem more and more complicated for the governmental circles from Bucharest and for Romanian diplomacy, too. The development of the so called „Jewish question” from an internal economic and social problem into a external political one was produced at the initiative and with large support of the World Jewish Alliance (founded in Paris in 1860). Together with the American Independent Order „B’nai B’rith”, the two organizations succeded to initiate and develop, by various means, a strong diplomatic pressure against Romania, in order to require her to respect proper obligations assumed by the decisions of the Congress of Berlin in 1878. The beginning of that pressure was marked by the American diplomats, either from Constantinopol, Bucharest or Washington D.C., and increased constantly up to the first decade of the XX-th Century. Otherwise, all the diplomatic and economic relations between the United States of America and Romania, since 1866 up to the end of the First World War, were dependent by the attitude of the decisional political factors from Bucharest on the Jewish question. The situation did not improve with the coming of the new Century, and in fact worsened. To the reasons already existing for the low level of bilateral relations, another aggravating element of economic and social nature was added, but dressed in strident political terms.The Jewish question was again revitalized, fostered by immigration to America, with its maximum intensity situated around the turn of the century, when the American authorities reacted in a manner and used means rejected by the Romanian political class and which were not shared by the majority of European powers. The cause was a diplomatic Appeal launched in 1902 by the American Secretary of State, John Hay, seeking to revitalise a diplomatic pressure against Romania, a gesture proved later to be inopportune and insincere on the part of its initiator. Fortunately, the unfavorable effects of the Romanian-American diplomatic incident of 1902, the motivation for which (real or supposed) underlined the primordial place or role of the Jewish question in the ensemble of relations between the two countries, were overcome by a better understanding in Washington of the political realities in the region and certainly through the efforts of its diplomatic representatives accredited in Romania.
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- 2009
8. Les dilemmes, les controverses et les conséquences d’une alliance politique conjecturale. Les relations roumaino-russes des années 1877-1878
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Dumitru Vitcu
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History (General) ,D1-2009 - Published
- 2008
9. Naţionalism şi modernizare în secolul XIX românesc
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Dumitru Vitcu
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History (General) ,D1-2009 - Published
- 2007
10. „Frontiere' şi „identităţi' în istoriografia românească postdecembristă
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Ştefan Purici, Harieta Mareci, and Dumitru Vitcu
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Frontiers ,Identities ,romanian historiography ,history ,ideological constructions ,History (General) ,D1-2009 - Published
- 2005
11. Personalitatea şi epoca lui Ştefan cel Mare în creaţia istoriografică a unui romantic
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Dumitru Vitcu
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History (General) ,D1-2009 - Published
- 2004
12. Whole Body Biodistribution and Radiation Dosimetry in Humans of a New PET Ligand, [18F]-FEPPA, to Image Translocator Protein (18 kDa)
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Mizrahi, Romina, Rusjan, Pablo M., Vitcu, Irina, Ng, Alvina, Wilson, Alan A., Houle, Sylvain, and Bloomfield, Peter M.
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- 2013
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13. „TE ÎNTREABĂ ȘI SOCOATE...” CE A FOST RĂU ȘI CE E BINE.
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VITCU, Dionisie
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- 2024
14. Biodistribution and Radiation Dosimetry of the Serotonin 5-HT6 Ligand [11C]GSK215083 Determined from Human Whole-Body PET
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Comley, Robert A., Salinas, Cristian, Mizrahi, Romina, Vitcu, Irina, Ng, Alvina, Hallett, William, Keat, Nicholas, Wilson, Alan A., Rabiner, Eugenii A., Laruelle, Marc, and Houle, Sylvain
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- 2012
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15. Low basal levels of circulating adiponectin in patients undergoing coronary stenting predict in-stent restenosis, independently of basal levels of inflammatory markers: Lipoprotein associated phospholipase A2, and myeloperoxidase
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Moldoveanu, Elena, Mut-Vitcu, Bogdan, Tanaseanu, George R., Marta, Daciana S., Manea, Gabriela, Kosaka, Tetsuya, Vidulescu, Cristina, and Tanaseanu, Cristina
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- 2008
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16. Clinical improvement after treatment with VEGF165 in patients with severe chronic lower limb ischaemia
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Anghel, Andrei, Mut-Vitcu, Bogdan, Savu, Lorand, Marian, Catalin, Seclaman, Edward, Iman, Raluca, Neghina, Adriana-Maria, and Dragulescu, Stefan I.
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- 2007
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17. Neuroimaging and Dissociative Disorders
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Staniloiu, Angelica, primary, Vitcu, Irina, additional, and J., Hans, additional
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- 2012
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18. High-resolution tunable mid-infrare spectrometer d based on difference-frequency generation in AgGa[S.sub.2]
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Vitcu, Adrian, Ciurylo, Richard, Wehr, Roman, Drummond, James R., and May, A. David
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Greenhouse gases -- Measurement ,Optical spectrometers ,Astronomy ,Physics - Abstract
We have built a high-resolution and high-signal-to-noise ratio spectrometer for line shape studies of greenhouse gases in the mid infrared. The infrared radiation is generated in a AgGa[S.sub.2] nonlinear crystal by the well-known difference-frequency method. The choice of crystal is explained, and a brief literature review is presented. With two tunable dye lasers and a type I, 90[degrees] phase-matching geometry, the infrared is continuously tunable from 7 to 9 [micro]m when Rhodamine 6G and Sulforhodamine 640 dyes are used. The total infrared power exceeds 30 nW and is limited by both the damage threshold and thermal loading of the crystal. Phase-sensitive detection allows us to reach signal-to-noise ratios in excess of 3500:1 while maintaining an instrumental linewidth of 1.5 MHz. However, we show that the spectrometer may be used to measure the positions of spectral lines within [+ or -] 400 kHz. OCIS codes: 300.6190, 300.6340, 120.6200, 160.4330, 190.2620, 190.4400.
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- 2004
19. Dynamic spectroscopic measurements of the temperature and pressure cycles in a MOPITT pressure modulator cell
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Wehr, Richard, McKernan, Eamonn, Vitcu, Adrian, Ciurylo, Roman, and Drummond, James R.
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Spectroscope -- Research ,Astronomy ,Physics - Abstract
The temperature and pressure cycles inside a pressure modulator cell (PMC) of the type used for gas-correlation radiometry aboard the Measurements of Pollution in the Troposphere (MOPITT) satellite instrument have been determined from dynamic measurements of the spectral line shapes of the R(0) and R(18) transitions in the fundamental vibrational--rotational band of carbon monoxide. The line strengths and linewidths were used to calculate the temperature and pressure, respectively, with a temporal resolution of approximately 200 [micro]s, or 1/100 of a PMC cycle. The results are compared with a thermodynamic box model. OCIS codes: 120.0280, 300.6340, 020.3690, 120.5630, 300.6360, 280.1120.
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- 2003
20. COOPERAREA RUSO-ROMÂNĂ DIN ANII 1877-1878 ÎN REPORTAJELE CORESPONDENŢILOR AMERICANI DE RĂZBOI PE FRONTUL BALCANIC.
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VITCU, DUMITRU
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POLITICAL attitudes ,WAR correspondents ,GEOGRAPHICAL positions ,PUBLIC opinion ,WAR ,CONSTITUTIONAL history ,TRANSTHEORETICAL model of change - Abstract
The Eastern Question, with its climax in the second part of the nineteenth century, the Russo-Turkish War of 1877-1878, refocused attention of the public and political opinion from abroad on one of the most turbulent areas of the world, namely the Balkans, justly characterized either as the "powder keg of Europe", or as a "laboratory of history". The geographical position, political aims and the international legal status did not allow Romania to stay out of the conflict. The Romanian political goal of winning the national state independence, following a realistic evaluation of the general European conditions and the unsuccessful diplomatic initiatives to remain neutral in the Balkan crisis, was to be achieved by developing a close cooperation with Russia. The Romanian willingness to follow this road, in spite of old anti-Russian feelings, was a significant and a radical political option, underlined by the numerous war correspondents, in their illustrative and comprehensible writings (narratives, notes or correspondences) sent to many European or American newspapers. The pact with Russia at the outbreak of the War, in April 1877, enabled Danubian Romanians to dodge the full costs of armed conflict. A declaration of independence and battlefield exploits filled Romanians with glorious self-esteem, but the peace-making process involved difficult issues for them, having to confront with the loss of southern Bessarabia, amending their Constitution, naturalizing some of the indigenous Jews, and finally purchasing proper railroads from a German company. However, on the whole, the result of the War for Romania was a major success, given the circumstances which could not be controlled due to their unpredictable nature. Regarding Russia, whose contribution in the historic moment which symbolized the first step towards Greater Romania, namely the inclusion of Dobruja in the frontiers of the Romanian national state, it managed to impose itself as a decisional factor in the continental "balance of powers". [ABSTRACT FROM AUTHOR]
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- 2022
21. Dicke-narrowed spectral line shapes of CO in Ar: Experimental results and a revised interpretation
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Wehr, R., Ciuryło, R., Vitcu, A., Thibault, F., Drummond, J.R., and May, A.D.
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- 2006
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22. Collisional line shifting and broadening in the fundamental P-branch of CO in Ar between 214 and 324 K
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Wehr, R., Vitcu, A., Thibault, F., Drummond, J.R., and May, A.D.
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- 2006
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23. An automated method for the extraction of regional data from PET images
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Rusjan, Pablo, Mamo, David, Ginovart, Nathalie, Hussey, Douglas, Vitcu, Irina, Yasuno, Fumihiko, Tetsuya, Suhara, Houle, Sylvain, and Kapur, Shitij
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- 2006
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24. Quantitation of Translocator Protein Binding in Human Brain with the Novel Radioligand [18F]-FEPPA and Positron Emission Tomography
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Rusjan, Pablo M, Wilson, Alan A, Bloomfield, Peter M, Vitcu, Irina, Meyer, Jeffrey H, Houle, Sylvain, and Mizrahi, Romina
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- 2011
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25. Body Mass Index and Glycaemic Control in Patients with Diabetes Mellitus: A Case-Control Study
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Iuliana-Claudia Hudrea, Laura Gaiţă, Gabriela Mut-Vitcu, Svetlana Mosteoru, and Dan Gaiţă
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medicine.medical_specialty ,endocrine system diseases ,business.industry ,Case-control study ,nutritional and metabolic diseases ,Specialties of internal medicine ,030209 endocrinology & metabolism ,body mass index ,medicine.disease ,03 medical and health sciences ,0302 clinical medicine ,RC581-951 ,Diabetes mellitus ,Internal medicine ,diabetes mellitus ,Endocrinology diabetology ,glycemic control ,Medicine ,In patient ,030212 general & internal medicine ,business ,Body mass index - Abstract
Background and Aims: Recent studies have brought evidence on the connection between excess weight and suboptimal glycemic control for Diabetes Mellitus (DM) patients. The aim of this study was to evaluate the association between increased Body Mass Index (BMI) and the likelihood of having suboptimal glycemic control in patients with Type 1 and Type 2 Diabetes Mellitus. Materials and Methods: A case-control study was conducted on 662 patients suffering from Diabetes Mellitus and statistical analysis was performed in order obtain evidence associating BMI and poor glycaemic control. We defined as increased BMI, values >25 kg/m2 and a hemoglobin A1c (HbA1c) value >7% reflected suboptimal glycemic control. Results: 559 (84%) patients had HbA1c >7%. 550 (83 %) patients had a BMI >25 kg/m2. In case of HbA1c >7%, a BMI >25 kg/m2 was found in a number of 457 patients (82 %), whereas a normal BMI was present in 102 (18%) patients. For the HbA1c25 kg/m2 was 93 (90%) and a normal BMI was present in 10 (10%) patients. BMI >25 kg/m2 was not associated with a higher probability of having above-target HbA1c values compared to patients with target HbA1c (OR 0.48, 95% CI: 0.24 to 0.95), with a statistically significant p 25 kg/m2 was significantly higher than the number of patients with a BMI < 25 kg/m2, a BMI above target was not associated with greater odds of having HbA1c higher than the standard 7% level, compared to individuals with normal HbA1c levels. The results emphasize that a multitude of factors are involved in the process of achieving a targeted glycemic control and a stepped-care approach should be considered for optimum management of Diabetes Mellitus.
- Published
- 2017
26. Unusual Cause of Heart Failure in a 65-Year-Old Woman
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Tomescu, Mirela, Rusinaru, Dan, Mut-Vitcu, Bogdan, Cocora, Mioara, Mavrea, Adelina, Citu, Ioana, and Dragulescu, Stefan Iosif
- Published
- 2008
27. Continuing Medical Education Program in Echocardiography
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Tomescu, Mirela, Rusinaru, Dan, Mut-Vitcu, Bogdan, Cocora, Mioara, Mavrea, Adelina, Citu, Ioana, and Dragulescu, Stefan Iosif
- Published
- 2008
28. Brain region binding of the D2/3 agonist [11C]-(+)-PHNO and the D2/3 antagonist [11C]raclopride in healthy humans
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Graff-Guerrero, Ariel, Willeit, Matthaeus, Ginovart, Nathalie, Mamo, David, Mizrahi, Romina, Rusjan, Pablo, Vitcu, Irina, Seeman, Philip, Wilson, Alan A., and Kapur, Shitij
- Published
- 2008
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29. Separate brain regions code for salience vs. valence during reward prediction in humans
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Jensen, Jimmy, Smith, Andrew J., Willeit, Matthäus, Crawley, Adrian P., Mikulis, David J., Vitcu, Irina, and Kapur, Shitij
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- 2007
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30. Effects of d-amphetamine on binding of the new D2/3 receptor agonist radioligand [11C]-(+)-PHNO in humans
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Willeit, Matthaeus, Ginovart, N., Graff, A., Rusjan, P., Bloomfield, P., Vitcu, I., Houle, S., Wilson, A. A., and Kapur, S.
- Published
- 2006
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31. Positron emission tomography quantification of [11C]-(+)-PHNO binding to the dopamine D2/D3 receptors in the human brain
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Ginovart, Nathalie, Willeit, M., Rusjan, P., Graff, A., Vitcu, I., Bloomfield, P., Houle, S., Kapur, S., and Wilson, A.
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- 2006
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32. Broadening, shifting, and line mixing in the 03 10 ← 01 10 parallel Q branch of N 2O
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Vitcu, A., Ciurylo, R., Wehr, R., Drummond, J.R., and May, A.D.
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- 2004
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33. Romanian registry for familial hypercholesterolemia: A tale that starts today
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P. Blaj, C. Lengher, Andreea Dumitrescu, S. Mancas, L. Gaita, Svetlana Mosteoru, Gabriela Mut-Vitcu, and Dan Gaita
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medicine.medical_specialty ,business.industry ,Family medicine ,Romanian ,medicine ,language ,Familial hypercholesterolemia ,Cardiology and Cardiovascular Medicine ,medicine.disease ,business ,language.human_language - Published
- 2018
34. Romanian registry for familial hypercholesterolemia: A tale that starts today
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Mosteoru, S., primary, Dumitrescu, A., additional, Blaj, P., additional, Lengher, C., additional, Gaita, L., additional, Mut-Vitcu, G., additional, Mancas, S., additional, and Gaita, D., additional
- Published
- 2018
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35. Management and outcome of patients with established coronary artery disease: the Euro Heart Survey on coronary revascularization
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Lenzen, M. J., Boersma, E., Bertrand, M. E., Maier, W., Moris, C., Piscione, F., Sechtem, U., Stahle, E., Widimsky, P., De Jaegere, P., Scholte Op Reimer, W. J. M., Mercado, N., Wijns, W., Meier, B., Sergeant, P., Vos, J., Unger, F., Manini, Malika, Bramley, Claire, Laforest, Valérie, Taylor, Charles, Del Gaiso, Susan, Huber, Kurt, De Backer, Guy, Sirakova, Vera, Cerbak, Roman, Thayssen, Per, Lehto, Seppo, Blanc, Jean-Jacques, Delahaye, François, Kobulia, Bondo, Zeymer, Uwe, Cokkinos, Dennis, Karlocai, Kristof, Graham, Ian, Shelley, Emer, Behar, Shlomo, Maggioni, Aldo, Grabauskiene, Virginija, Deckers, Jaap, Asmussen, Inger, Stepinska, Janina, Gonçalves, Lino, Mareev, Vyacheslav, Riecansky, Igor, Kenda, Miran F., Alonso, Angeles, Lopez-Sendon, José Luis, Rosengren, Annika, Buser, Peter, Okay, Tugrul, Sychov, Oleg, Fox, Kevin, Wood, David, Boersma, Eric, Crijns, Harry, Fox, Kim, McGregor, Keith, Mulder, Barbara, Priori, Sylvia, Rydén, Lars, Tavazzi, Luigi, Vahanian, Alec, Vardas, Panos, Wijns, William, Sarkisyan, Karine, Glogar, H. D., Derntl, Michael, Frick, Matthias, Pachinger, O., Zwick, Ralf, Vrints, Christiaan, Van Hertbruggen, Els, Vercammen, Marc, Sysmans, Tineke, Schroeder, E., Domange, Juliette, De Pril, Hilde, De Vriese, Johan, Van Hecke, Tonny, Legrand, V., Gillon, Marie-France, Richardy, Michel, Doneux, P., Petrov, Ivo, Jorgova, J., Starcevic, Boris, Eeckhout, Eric, Berger, Alexandre, Prudent, Veronique, Camenzind, E., Masson, Nicolas, Zambartas, Costas, Kleanthous, Helen, Widimsky, Petr, Stellova, Blanka, Aschermann, Michael, Simek, Stanislav, Kautzner, J., Karmazin, Vladimir, Svab, P., Indrak, Jan, Branny, M., Hladilova, Kveta, Kala, P., Thayssen, P., Cappelen, Helle, Jensen, Lisette Okkels, Gitt, A., Gehrke, Konstanze, Erbel, R., Gutersohn, Achim, Eggebrecht, Holger, Al Khani, Murad, Sechtem, Udo, Rosenberger, Antje, Vogelsberg, Holger, Klepzig, H., Schmidt, Arnold, Silber, Sigmund, Mau, Birgit, Leuner, Christian, Czyborra, Karen, Reuschling, Christina, Muno, Eva, Kleber, F., Rux, Sascha, Zeymer, U., Saad, Aly, Ibrahim, B. S. S., Elabady, Maged, Castro Beiras, A., Fernandez, Jorge Salgado, Navarro Del Arno, Felipe, Iniguez Romo, A., Cruz Fernandez, J. M., Mayoreal, Alejandro Recio, Rebanal, Franciso Javier Rivero, De La Borbolla, Mariano Garcia, Chaparro, Marinela, Brotons, C., Permanyer Miralda, C., Vilai Perez, Srta Irma, Moris, Cesar, Fernandez Aviles, F., De La Fuente Galan, Luis, Vinuela, Paula Tejedor, Malpartida De Torres, F., Mora, Javier, Rodriguez, Ignacio Santos, Bustamante, Itziar Piedra, Sanchez Fernandez, Pedro L., Diago Torrent, J. L., Diez Gil, Jose L., Perpinan, Javier, Palacios Motilla, V., Soledad Alcasena Juango, M., Berjon-Reyero, Jesus, Melgares Moreno, R., Guerrero, Juan Carlos Fernandez, Lehto, S., Savolainen, Kirsti, Nieminen, M. S., Syvanne, Mikko, Cohen-Solal, A., Oboa, Antoine-Sylvain, Bassand, J. P., Espinosa, Denis Pales, Jouet, Veronique, Montalescot, G., Gallois, Vanessa, Daubert, J. C., Clerc, Jean Michel, Machecourt, Jacques, Cottin, Y., Walker, D., Holland, Fhiona, Wood, D., Prosser, Jenni, Muir, Lis, Barber, Kate, Cleland, J. G. F., Cook, Jocelyn, Chapichadze, Zaza, Christos, Ioannis Skoularigisn Athanasiou, Tsiavou, Nastasia, Chrysohoou, Christina, Manginas, Athanassios, Terrovitis, John, Kanakakis, John, Vavuranakis, Manolis, Drakos, Stavros, Farmakis, Thomas, Samara, C., Papakosta, Christina, Bourantas, Christos, Michalis, L. K., Christos, Mpourantas, Foussas, Stefanos, Adamopoulou, Evdokia, Vardas, P. E., Marketou, Mary, Alotti, N., Basa, Anna Maria, Vigh, Andras, Preda, Istvan, Csoti, Eva, Keltai, M., Kerkovits, G., Hendler, Alberto, Blatt, Alex, Beyar, R., Shefer, Arie, Halon, David, Bentzvi, Margalait, Avramovitch, Naomi, Bakst, Avinoam, Cafri, Carlos, Grosbard, Aviva, Margolis, Bella, Suleiman, Khalid, Banai, Shmuel, Meerkin, David, Mosseri, Morris, Guita, Pnina, Jabara, Rifat, Jafari, Jamal, Ben Shitrit, Debi, Ghasan, null, Salameh, null, Brezins, Marc, Van Den Akker-Berman, Lily, Guetta, Victor, Rozenman, Yoseph, Biagini, A., Berti, Sergio, Ferrero, Massimo, Colombo, A., Roccaforte, R., Milici, Caterina, Scarpino, L., Salvi, A., Desideri, Alessandro, Sabbadin, Daniela, Galassi, Alfredo, Giuffrida, Giuseppe, Rognoni, Andrea, Vassanelli, Corrado, Paffoni, Paola, Cioppa, Angelo, Rubino, Paolo, De Carlo, Marco, Petronio, Anna Sonia, Naccarella, F., Saia, Francesco, Marzocchi, Antonio, Maranga, Stefano Sdringola, Presbitero, P., Valsecchi, Fazya, Piscione, Federico, Esposito, Giovanni, Santini, Napoli M., Tubaro, Marco, Erglis, A., Narbute, Inga, Kavoliuniene, Ausra, Zaliunas, R., Navickas, Ramunas, Grabauskiene, V., Luckute, Davia, Subkovas, Eduardas, Wagner, Daniel, Vermeer, F., Lousberg, Aimee, Fransen, Heidi, Breeman, Arno, Tebbe, Henriette, De Boer, M. J., Van Der Wal, Metske, Deckers, J., Vos, Jeroen, Leenders, C. M., Veerhoek, M. J., Jansen, Chris, Bijl, M., Koppelaar, Colinda, Van Den Linden, null, Brons, R., Widdershofen, J. W. M. G., Broers, Herman, Kontny, F., Jonzon, Marianne, Wodniecki, Jan, Tomasik, Andrzej, Trusz-Gluza, M., Nowak, Seweryn, Ruzyllo, Witold, Deptuch, Tomasz, Marques, Jorge, Matias, F., Madeira, H., Oliveira, Joaquim, Sargento, Luis, Ionac, Adina, Dragulescu, Iosif Stefan, Mut-Vitcu, Bogdan, Maximov, Daniela, Dorobantu, M., Apetrei, E., Niculescu, Rodica, Petrescu, Virgil, Bucsa, Adrian, Deleanu, Dan, Benedek, I. S., Hintea, Theodora, Aronov, D., Tikhomirova, Elena, Kranjec, I., Prokselj, Katja, Kanic, Vojko, Sepetoglu, Ahmet, Aytekin, S., Aytekin, V., Catakoglu, Alp Burak, Parlar, Hayri, Tufekcioglu, Suavi, Ozyedek, Zeki, Baltali, Mehmet, Kiziltan, null, Vukovic, Milan, Neskovic, A. N., Lenzen, M. J, Boersma, E, Bertrand, Me, Maier, W, Moris, C, Esposito, Giovanni, Piscione, Federico, Sechtem, U, Stahle, E, Widimsky, P, de Jaegere, P, Scholte op Reimer, W. J. M, Mercado, N, Wijns, W., University of Zurich, Wijns, W, Lenzen, M. J., Boersma, E., Bertrand, M. E., Maier, W., Moris, C., Piscione, F., Sechtem, U., Stahle, E., Widimsky, P., De Jaegere, P., Scholte Op Reimer, W. J. M., Mercado, N., Meier, B., Sergeant, P., Vos, J., Unger, F., Manini, Malika, Bramley, Claire, Laforest, Valérie, Taylor, Charle, Del Gaiso, Susan, Huber, Kurt, De Backer, Guy, Sirakova, Vera, Cerbak, Roman, Thayssen, Per, Lehto, Seppo, Blanc, Jean-Jacque, Delahaye, Françoi, Kobulia, Bondo, Zeymer, Uwe, Cokkinos, Denni, Karlocai, Kristof, Graham, Ian, Shelley, Emer, Behar, Shlomo, Maggioni, Aldo, Grabauskiene, Virginija, Deckers, Jaap, Asmussen, Inger, Stepinska, Janina, Gonçalves, Lino, Mareev, Vyacheslav, Riecansky, Igor, Kenda, Miran F., Alonso, Angele, Lopez-Sendon, José Lui, Rosengren, Annika, Buser, Peter, Okay, Tugrul, Sychov, Oleg, Fox, Kevin, Wood, David, Boersma, Eric, Crijns, Harry, Fox, Kim, Mcgregor, Keith, Mulder, Barbara, Priori, Sylvia, Rydén, Lar, Tavazzi, Luigi, Vahanian, Alec, Vardas, Pano, Wijns, William, Sarkisyan, Karine, Glogar, H. D., Derntl, Michael, Frick, Matthia, Pachinger, O., Zwick, Ralf, Vrints, Christiaan, Van Hertbruggen, El, Vercammen, Marc, Sysmans, Tineke, Schroeder, E., Domange, Juliette, De Pril, Hilde, De Vriese, Johan, Van Hecke, Tonny, Legrand, V., Gillon, Marie-France, Richardy, Michel, Doneux, P., Petrov, Ivo, Jorgova, J., Starcevic, Bori, Eeckhout, Eric, Berger, Alexandre, Prudent, Veronique, Camenzind, E., Masson, Nicola, Zambartas, Costa, Kleanthous, Helen, Widimsky, Petr, Stellova, Blanka, Aschermann, Michael, Simek, Stanislav, Kautzner, J., Karmazin, Vladimir, Svab, P., Indrak, Jan, Branny, M., Hladilova, Kveta, Kala, P., Thayssen, P., Cappelen, Helle, Jensen, Lisette Okkel, Gitt, A., Gehrke, Konstanze, Erbel, R., Gutersohn, Achim, Eggebrecht, Holger, Al Khani, Murad, Sechtem, Udo, Rosenberger, Antje, Vogelsberg, Holger, Klepzig, H., Schmidt, Arnold, Silber, Sigmund, Mau, Birgit, Leuner, Christian, Czyborra, Karen, Reuschling, Christina, Muno, Eva, Kleber, F., Rux, Sascha, Zeymer, U., Saad, Aly, Ibrahim, B. S. S., Elabady, Maged, Castro Beiras, A., Fernandez, Jorge Salgado, Navarro Del Arno, Felipe, Iniguez Romo, A., Cruz Fernandez, J. M., Mayoreal, Alejandro Recio, Rebanal, Franciso Javier Rivero, De La Borbolla, Mariano Garcia, Chaparro, Marinela, Brotons, C., Permanyer Miralda, C., Vilai Perez, Srta Irma, Moris, Cesar, Fernandez Aviles, F., De La Fuente Galan, Lui, Vinuela, Paula Tejedor, Malpartida De Torres, F., Mora, Javier, Rodriguez, Ignacio Santo, Bustamante, Itziar Piedra, Sanchez Fernandez, Pedro L., Diago Torrent, J. L., Diez Gil, Jose L., Perpinan, Javier, Palacios Motilla, V., Soledad Alcasena Juango, M., Berjon-Reyero, Jesu, Melgares Moreno, R., Guerrero, Juan Carlos Fernandez, Lehto, S., Savolainen, Kirsti, Nieminen, M. S., Syvanne, Mikko, Cohen-Solal, A., Oboa, Antoine-Sylvain, Bassand, J. P., Espinosa, Denis Pale, Jouet, Veronique, Montalescot, G., Gallois, Vanessa, Daubert, J. C., Clerc, Jean Michel, Machecourt, Jacque, Cottin, Y., Walker, D., Holland, Fhiona, Wood, D., Prosser, Jenni, Muir, Li, Barber, Kate, Cleland, J. G. F., Cook, Jocelyn, Chapichadze, Zaza, Christos, Ioannis Skoularigisn Athanasiou, Tsiavou, Nastasia, Chrysohoou, Christina, Manginas, Athanassio, Terrovitis, John, Kanakakis, John, Vavuranakis, Manoli, Drakos, Stavro, Farmakis, Thoma, Samara, C., Papakosta, Christina, Bourantas, Christo, Michalis, L. K., Christos, Mpouranta, Foussas, Stefano, Adamopoulou, Evdokia, Vardas, P. E., Marketou, Mary, Alotti, N., Basa, Anna Maria, Vigh, Andra, Preda, Istvan, Csoti, Eva, Keltai, M., Kerkovits, G., Hendler, Alberto, Blatt, Alex, Beyar, R., Shefer, Arie, Halon, David, Bentzvi, Margalait, Avramovitch, Naomi, Bakst, Avinoam, Cafri, Carlo, Grosbard, Aviva, Margolis, Bella, Suleiman, Khalid, Banai, Shmuel, Meerkin, David, Mosseri, Morri, Guita, Pnina, Jabara, Rifat, Jafari, Jamal, Ben Shitrit, Debi, Ghasan, Null, Salameh, Null, Brezins, Marc, Van Den Akker-Berman, Lily, Guetta, Victor, Rozenman, Yoseph, Biagini, A., Berti, Sergio, Ferrero, Massimo, Colombo, A., Roccaforte, R., Milici, Caterina, Scarpino, L., Salvi, A., Desideri, Alessandro, Sabbadin, Daniela, Galassi, Alfredo, Giuffrida, Giuseppe, Rognoni, Andrea, Vassanelli, Corrado, Paffoni, Paola, Cioppa, Angelo, Rubino, Paolo, De Carlo, Marco, Petronio, Anna Sonia, Naccarella, F., Saia, Francesco, Marzocchi, Antonio, Maranga, Stefano Sdringola, Presbitero, P., Valsecchi, Fazya, Santini, Napoli M., Tubaro, Marco, Erglis, A., Narbute, Inga, Kavoliuniene, Ausra, Zaliunas, R., Navickas, Ramuna, Grabauskiene, V., Luckute, Davia, Subkovas, Eduarda, Wagner, Daniel, Vermeer, F., Lousberg, Aimee, Fransen, Heidi, Breeman, Arno, Tebbe, Henriette, De Boer, M. J., Van Der Wal, Metske, Deckers, J., Vos, Jeroen, Leenders, C. M., Veerhoek, M. J., Jansen, Chri, Bijl, M., Koppelaar, Colinda, Van Den Linden, Null, Brons, R., Widdershofen, J. W. M. G., Broers, Herman, Kontny, F., Jonzon, Marianne, Wodniecki, Jan, Tomasik, Andrzej, Trusz-Gluza, M., Nowak, Seweryn, Ruzyllo, Witold, Deptuch, Tomasz, Marques, Jorge, Matias, F., Madeira, H., Oliveira, Joaquim, Sargento, Lui, Ionac, Adina, Dragulescu, Iosif Stefan, Mut-Vitcu, Bogdan, Maximov, Daniela, Dorobantu, M., Apetrei, E., Niculescu, Rodica, Petrescu, Virgil, Bucsa, Adrian, Deleanu, Dan, Benedek, I. S., Hintea, Theodora, Aronov, D., Tikhomirova, Elena, Kranjec, I., Prokselj, Katja, Kanic, Vojko, Sepetoglu, Ahmet, Aytekin, S., Aytekin, V., Catakoglu, Alp Burak, Parlar, Hayri, Tufekcioglu, Suavi, Ozyedek, Zeki, Baltali, Mehmet, Kiziltan, Null, Vukovic, Milan, Neskovic, A. N., Cardiology, Lenzen, Mj, and Scholte op Reimer, Wj
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Practice survey ,Male ,Coronary Stenosi ,Coronary angiography ,medicine.medical_treatment ,Myocardial Infarction ,Coronary Artery Disease ,Angina ,Coronary artery disease ,Myocardial Revascularization ,Stent ,Myocardial infarction ,Coronary Artery Bypass ,Angioplasty, Balloon, Coronary ,CABG ,PCI ,Professional Practice ,Health Survey ,Middle Aged ,Europe ,Treatment Outcome ,Epidemiologic Method ,Practice Guidelines as Topic ,Cardiology ,Stents ,Female ,Guideline Adherence ,Cardiology and Cardiovascular Medicine ,Human ,medicine.medical_specialty ,outcome ,Euro Heart Survey ,610 Medicine & health ,Platelet Glycoprotein GPIIb-IIIa Complex ,142-005 142-005 ,2705 Cardiology and Cardiovascular Medicine ,Angioplasty ,Internal medicine ,medicine ,Humans ,Angina, Unstable ,cardiovascular diseases ,Interventional cardiology ,Unstable angina ,business.industry ,Coronary Artery Bypa ,Coronary Stenosis ,Percutaneous coronary intervention ,Length of Stay ,medicine.disease ,Health Surveys ,Conventional PCI ,570 Life sciences ,biology ,Epidemiologic Methods ,business - Abstract
AIMS: The purpose of the Euro Heart Survey Programme of the European Society of Cardiology is to evaluate to which extent clinical practice endorses existing guidelines as well as to identify differences in population profiles, patient management, and outcome across Europe. The current survey focuses on the invasive diagnosis and treatment of patients with established coronary artery disease (CAD). METHODS AND RESULTS: Between November 2001 and March 2002, 7769 consecutive patients undergoing invasive evaluation at 130 hospitals (31 countries) were screened for the presence of one or more coronary stenosis >50% in diameter. Patient demographics and comorbidity, clinical presentation, invasive parameters, treatment options, and procedural techniques were prospectively entered in an electronic database (550 variables+29 per diseased coronary segment). Major adverse cardiac events (MACE) were evaluated at 30 days and 1 year. Out of 5619 patients with angiographically proven coronary stenosis (72% of screened population), 53% presented with stable angina while ST elevation myocardial infarction (STEMI) was the indication for coronary angiography in 16% and non-ST segment elevation myocardial infarction or unstable angina in 30%. Only medical therapy was continued in 21%, whereas mechanical revascularization was performed in the remainder [percutaneous coronary intervention (PCI) in 58% and coronary artery bypass grafting (CABG) in 21%]. Patients referred for PCI were younger, were more active, had a lower risk profile, and had less comorbid conditions. CABG was performed mostly in patients with left main lesions (21%), two- (25%), or three-vessel disease (67%) with 4.1 diseased segments, on average. Single-vessel PCI was performed in 82% of patients with either single- (45%), two- (33%), or three-vessel disease (21%). Stents were used in 75% of attempted lesions, with a large variation between sites. Direct PCI for STEMI was performed in 410 cases, representing 7% of the entire workload in the participating catheterization laboratories. Time delay was within 90 min in 76% of direct PCI cases. In keeping with the recommendations of practice guidelines, the survey identified under-use of adjunctive medication (GP IIb/IIIa receptor blockers, statins, and angiotensin-converting enzyme-inhibitors). Mortality rates at 30 days and 1 year were low in all subgroups. MACE primarily consisted of repeat PCI (12%). CONCLUSION: The current Euro Heart Survey on coronary revascularization was performed in the era of bare metal stenting and provides a global European picture of the invasive approach to patients with CAD. These data will serve as a benchmark for the future evaluation of the impact of drug-eluting stents on the practice of interventional cardiology and bypass surgery.
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- 2005
36. Broadening and line mixing in the 20 00←01 10, 11 10←00 00 and 12 20←01 10 Q branches of carbon dioxide: Experimental results and energy-corrected sudden modeling.
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Predoi-Cross, A., May, A. D., Vitcu, A., Drummond, J. R., Hartmann, J.-M., and Boulet, C.
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MIXING ,FLUID dynamics ,HYDRODYNAMICS ,CARBON dioxide ,CARBON compounds ,SPECTROMETERS ,FOURIER analysis - Abstract
Using both a difference frequency spectrometer and a Fourier transform spectrometer, we have measured transitions in the 12
2 0←011 0 band of carbon dioxide at room temperature and pressures up to 19 atm. The low-pressure spectra were analyzed using a variety of standard spectral profiles, all with an asymmetric component to account for weak line mixing. For this band, we have been able to retrieve experimental line strengths and the broadening and weak mixing parameters. In this paper we also compare the suitability of the energy-corrected sudden model to predict mixing in the two previously measured Q branches 200 0←011 0, the 111 0←000 0, and the present Q branch of pure CO2 , all at room temperature. [ABSTRACT FROM AUTHOR]- Published
- 2004
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- View/download PDF
37. Depression influences the quality of diabetes-related self-management activities in elderly patients with type 2 diabetes: a cross-sectional study
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Cristian Oancea, Bogdan Timar, Gabriela Mut-Vitcu, Ioan Cosmin Citu, and Romulus Timar
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Male ,medicine.medical_specialty ,Cross-sectional study ,media_common.quotation_subject ,030209 endocrinology & metabolism ,Type 2 diabetes ,Severity of Illness Index ,Diabetes Complications ,03 medical and health sciences ,0302 clinical medicine ,Quality of life (healthcare) ,Diabetes mellitus ,Surveys and Questionnaires ,self-care ,Medicine ,Humans ,Quality (business) ,030212 general & internal medicine ,Exercise ,Depression (differential diagnoses) ,media_common ,Aged ,Original Research ,Aged, 80 and over ,Psychiatric Status Rating Scales ,Self-management ,diabetes ,business.industry ,Depression ,Romania ,General Medicine ,Middle Aged ,medicine.disease ,Self Care ,Cross-Sectional Studies ,Logistic Models ,Diabetes Mellitus, Type 2 ,quality of life ,Clinical Interventions in Aging ,Multivariate Analysis ,Self care ,Physical therapy ,Female ,Geriatrics and Gerontology ,business - Abstract
Gabriela Mut-Vitcu,1 Bogdan Timar,2 Romulus Timar,1 Cristian Oancea,3 Ioan Cosmin Citu4 1Second Department of Internal Medicine, 2Department of Functional Sciences, 3Department of Infectious Diseases, 4Department of Obstetrics and Gynecology, “Victor Babes” University of Medicine and Pharmacy, Timisoara, Romania Purpose: To evaluate the prevalence of depression and its impact on the quality of diabetes-related self-care activities in elderly patients with type 2 diabetes. Patients and methods: In this cross-sectional study, 184 patients with type 2 diabetes were enrolled. Depression was evaluated using Patient Health Questionnaire-9 while the quality of diabetes-related self-care activities was assessed using the Summary of Diabetes-Related Self Care Activities Questionnaire. Results: In our study group, 53.3% of the patients had moderate depression, 17.9% had severe depression, and 28.8% had no depression symptoms. Patient’s age (P=0.024), presence of diabetic neuropathy (P
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- 2016
38. Whole-Body Distribution and Radiation Dosimetry of 11C-(+)-PHNO, a D2/3 Agonist Ligand
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Alvina Ng, Alan A. Wilson, Peter M. Bloomfield, Pablo Rusjan, Romina Mizrahi, Irina Vitcu, and Sylvain Houle
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Adult ,Male ,Agonist ,Adult male ,medicine.drug_class ,Radiation ,Ligands ,Effective dose (radiation) ,Oxazines ,medicine ,Humans ,Dosimetry ,Tissue Distribution ,Radiology, Nuclear Medicine and imaging ,Radiometry ,Receptors, Dopamine D2 ,business.industry ,Receptors, Dopamine D3 ,Healthy subjects ,Internal radiation ,Organ Size ,Positron-Emission Tomography ,Dopamine Agonists ,Female ,Whole body ,Nuclear medicine ,business - Abstract
Using PET, we measured the whole-body distribution of 11C-(+)-PHNO (11C-(+)-4-propyl-9-hydroxynaphthoxazine), a D2/3 agonist, as a function of time in adult subjects in order to determine the internal radiation dose. Methods: PET whole-body data were acquired after the injection of 11C-(+)-PHNO (∼360 MBq) in 6 healthy subjects (3 male and 3 female). The PET acquisition duration was a maximum of 112.5 min, and 9 discrete time frames were obtained. After reconstruction of the emission data, 6 organs were identified in the images as exhibiting uptake above background levels. Regions of interest were delineated on these organs, and time–activity curves were generated. The time–activity curve data were corrected for the injected activity, specific organ density, and volume, from which normalized accumulated activities (previously known as residence times) were calculated. The normalized accumulated activities were then used with the software code OLINDA/EXM 1.1 to calculate the internal doses for the standard adult male and female models. Results: The mean effective dose was estimated to be 4.5 ± 0.3 μSv/MBq when all subjects were included and the male model was applied for the dosimetry calculation, and the mean effective dose was estimated to be 5.2 ± 0.2 μSv/MBq when the females were considered separately and the female model was applied for the calculation. The organ receiving the highest dose was the liver (17.9 ± 3.9 μSv/MBq), followed by the kidneys (14.3 ± 3.6 μSv/MBq) and the urinary bladder wall (13.5 ± 3.7 μSv/MBq). Conclusion: The estimated radiation doses for 11C-(+)-PHNO are similar to those reported for other radiotracers labeled with 11C. 11C-(+)-PHNO may be used for multiple PET scans in the same subject and remain within regulatory guidelines.
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- 2012
39. DIN CEARCĂNELE VREMII DIN CEARCĂNELE VREMII.
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VITCU, Dionisie
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- 2020
40. Biodistribution and Radiation Dosimetry of the Serotonin 5-HT6 Ligand [11C]GSK215083 Determined from Human Whole-Body PET
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William A. Hallett, Marc Laruelle, Robert A. Comley, Alvina Ng, Sylvain Houle, Alan A. Wilson, Nicholas Keat, Cristian Salinas, Irina Vitcu, Eugenii A. Rabiner, and Romina Mizrahi
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Cancer Research ,Biodistribution ,medicine.diagnostic_test ,business.industry ,Equivalent dose ,Area under the curve ,Radiation ,Effective dose (radiation) ,Oncology ,Positron emission tomography ,medicine ,Dosimetry ,Radiology, Nuclear Medicine and imaging ,Serotonin ,business ,Nuclear medicine - Abstract
We measured the whole-body distribution of IV-injected [11C]GSK215083, a new 5-HT6 antagonist PET tracer, as a function of time in adult subjects, in order to determine the radiation exposure. After injection with a single bolus of [11C]GSK215083 (range 330–367 MBq; mean 346 MBq), PET emission data were acquired for approximately 120 min in six subjects (three males and three females). Five organs were identified as exhibiting uptake above background. For these, regions of interest were delineated on emission images, and time–activity curves (TAC) generated. Residence times were calculated as the area under the curve of the TAC, normalized to injected activities and standard values of organ volumes. Dosimetry calculations were then performed using the computer program OLINDA/EXM 1.0. The mean effective dose averaged over both males and females (±standard deviation) was estimated to be 7.7 ± 1.0 μSv/MBq (male 7.0 ± 0.4; female 8.5 ± 0.6). For the effective dose equivalent, the corresponding values are 7.8 ± 1.2 μSv/MBq (male 6.8 ± 0.5; female 8.9 ± 0.1). The organ receiving the highest dose was the lung, with an average equivalent dose of 25.6 ± 6.9 μSv/MBq (male 20.8 ± 5.6; female 30.4 ± 4.4). The estimated radiation dose for [11C]GSK215083 is consistent with those for other neuroreceptor ligands labeled with carbon-11. The somewhat higher dose estimate for females compared to males may reflect the difference in observed residence times and representative differences in the male and female phantoms used for dosimetry calculations. Based on conventionally accepted dose limits, [11C]GSK215083 may be used for multiple PET scans in the same subject.
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- 2011
41. Quantitation of Translocator Protein Binding in Human Brain with the Novel Radioligand [18F]-FEPPA and Positron Emission Tomography
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Peter M. Bloomfield, Pablo Rusjan, Irina Vitcu, Romina Mizrahi, Jeffrey H. Meyer, Sylvain Houle, and Alan A. Wilson
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Adult ,Male ,Fluorine Radioisotopes ,Pyridines ,Coefficient of variation ,Young Adult ,Translocator protein ,medicine ,Radioligand ,Humans ,Anilides ,Aged ,biology ,medicine.diagnostic_test ,business.industry ,Chemistry ,Outcome measures ,Brain ,Binding potential ,Human brain ,Middle Aged ,medicine.anatomical_structure ,Neurology ,Positron emission tomography ,Positron-Emission Tomography ,biology.protein ,Original Article ,Female ,Neurology (clinical) ,Tomography ,Radiopharmaceuticals ,Cardiology and Cardiovascular Medicine ,Nuclear medicine ,business ,Protein Binding - Abstract
This article describes the kinetic modeling of [18F]-FEPPA binding to translocator protein 18 kDa in the human brain using high-resolution research tomograph (HRRT) positron emission tomography. Positron emission tomography scans were performed in 12 healthy volunteers for 180 minutes. A two-tissue compartment model (2-CM) provided, with no exception, better fits to the data than a one-tissue model. Estimates of total distribution volume ( VT), specific distribution volume ( VS), and binding potential ( BPND) demonstrated very good identifiability (based on coefficient of variation ( COV)) for all the regions of interest (ROIs) in the gray matter ( COV VT < 7%, COV VS < 8%, COV BPND < 11%). Reduction of the length of the scan to 2 hours is feasible as VS and VT showed only a small bias (6% and 7.5%, respectively). Monte Carlo simulations showed that, even under conditions of a 500% increase in specific binding, the identifiability of VT and VS was still very good with COVT values obtained from an unconstrained 2-CM with data from a 2-hour scan support the use of VT as an appropriate and feasible outcome measure for [18F]-FEPPA.
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- 2011
42. Brain region binding of the D2/3 agonist [11C]-(+)-PHNO and the D2/3 antagonist [11C]raclopride in healthy humans
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Philip Seeman, Irina Vitcu, Pablo Rusjan, Romina Mizrahi, David C. Mamo, Shitij Kapur, Ariel Graff-Guerrero, Nathalie Ginovart, Alan A. Wilson, and Matthaeus Willeit
- Subjects
Male ,Time Factors ,Dopamine ,Striatum ,ddc:616.89 ,Substantia Nigra/diagnostic imaging/metabolism ,Basal ganglia ,Radioligand ,Tissue Distribution ,Carbon Radioisotopes ,Receptors, Dopamine D2/agonists/metabolism ,Research Articles ,Raclopride ,Brain Mapping ,Dopamine Agonists/metabolism/pharmacokinetics ,Radiological and Ultrasound Technology ,Chemistry ,Putamen ,Substantia Nigra ,Dopamine D2 Receptor Antagonists ,Globus pallidus ,Neurology ,Dopamine Agonists ,Female ,Anatomy ,medicine.drug ,Adult ,Agonist ,medicine.medical_specialty ,Raclopride/metabolism/pharmacokinetics ,medicine.drug_class ,Globus Pallidus ,Binding, Competitive ,Binding, Competitive/drug effects/physiology ,Internal medicine ,Brain Mapping/methods ,Oxazines ,medicine ,Humans ,Radiology, Nuclear Medicine and imaging ,Corpus Striatum/diagnostic imaging/metabolism ,Globus Pallidus/diagnostic imaging/metabolism ,Neostriatum/diagnostic imaging/metabolism ,Receptors, Dopamine D2 ,Antagonist ,Positron-Emission Tomography/methods ,Dopamine Antagonists/metabolism/pharmacokinetics ,Corpus Striatum ,Dopamine/metabolism ,Neostriatum ,Endocrinology ,nervous system ,Positron-Emission Tomography ,Dopamine Antagonists ,Oxazines/metabolism/pharmacokinetics ,Neurology (clinical) ,Neuroscience - Abstract
The D(2) receptors exist in either the high‐ or low‐affinity state with respect to agonists, and while agonists bind preferentially to the high‐affinity state, antagonists do not distinguish between the two states. [(11)C]‐(+)‐PHNO is a PET D(2) agonist radioligand and therefore provides a preferential measure of the D(2) (high) receptors. In contrast, [(11)C]raclopride is an antagonist radioligand and thus binds with equal affinity to the D(2) high‐ and low‐affinity states. The aim was to compare the brain uptake, distribution and binding characteristics between [(11)C]‐(+)‐PHNO and [(11)C]raclopride in volunteers using a within‐subject design. Both radioligands accumulated in brain areas rich in D(2)/D(3)‐receptors. However, [(11)C]‐(+)‐PHNO showed preferential uptake in the ventral striatum and globus pallidus, while [(11)C]raclopride showed preferential uptake in the dorsal striatum. Mean binding potentials were higher in the putamen (4.3 vs. 2.8) and caudate (3.4 vs 2.1) for [(11)C]raclopride, equal in the ventral‐striatum (3.4 vs. 3.3), and higher in the globus pallidus for [(11)C]‐(+)‐PHNO (1.8 vs. 3.3). Moreover [(11)C]‐(+)‐PHNO kinetics in the globus pallidus showed a slower washout than other regions. One explanation for the preferential binding of [(11)C]‐(+)‐PHNO in the globus pallidus and ventral‐striatum could be the presence of a greater proportion of high‐ vs. low‐affinity receptors in these areas. Alternatively, the observed distribution could also be explained by a preferential binding of D(3)‐over‐D(2) with [(11)C]‐(+)‐PHNO. This differential binding of agonist vs. antagonist radioligand, especially in the critically important region of the limbic striatum/pallidum, offers new avenues to investigate the role of the dopamine system in health and disease. Hum Brain Mapp 2008. © 2007 Wiley‐Liss, Inc.
- Published
- 2008
43. Lipid profile changes in a very high-risk cohort: Lessons from the EuroASPIRE database
- Author
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Mosteoru, Svetlana, primary, Kotseva, Kornelia, additional, Cosor, Oana Catalina, additional, Gaita, Laura, additional, Pleava, Roxana, additional, Dumitrescu, Andreea, additional, Mut-Vitcu, Gabriela, additional, Gaita, Dan, additional, Mancas, Silvia, additional, and Wood, David, additional
- Published
- 2017
- Full Text
- View/download PDF
44. Low body mass index analysis is associated with obstruction severity in chronic obstructive pulmonary disease patients in Romania
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Pleava, Roxana, primary, Ardelean, Carmen, additional, Frentz, Stefan, additional, Gaita, Laura, additional, Mosteoru, Svetlana, additional, Mut-Vitcu, Gabriela, additional, Dumitrescu, Andreea, additional, Gaita, Dan, additional, and Mihaicuta, Stefan, additional
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- 2017
- Full Text
- View/download PDF
45. Clinical improvement after treatment with VEGF165 in patients with severe chronic lower limb ischaemia
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Raluca Iman, Catalin Marian, Adriana-Maria Neghina, Edward Seclaman, Bogdan Mut-Vitcu, Æ Stefan I. Dragulescu, Andrei Anghel, and Lorand Savu
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medicine.medical_specialty ,medicine.medical_treatment ,Genetic enhancement ,chemistry.chemical_compound ,Gene therapy ,Text mining ,Internal medicine ,Genetics ,medicine ,Genetics(clinical) ,Adverse effect ,Saline ,Genetics (clinical) ,medicine.diagnostic_test ,business.industry ,Lower limb ischaemia ,Molecular medicine ,Surgery ,Vascular endothelial growth factor ,medicine.anatomical_structure ,chemistry ,Angiography ,Cardiology ,business ,Neo-vascularization ,Research Article ,Blood vessel - Abstract
The present study focuses on the application of a therapeutic strategy in patients with chronic severe lower limb ischaemia using a plasmid vector encoding the vascular endothelial growth factor (phVEGF165). It has been shown that VEGF promotes neo-vascularization and blood vessel network formation and thus might have the ability to improve blood-flow at the level of the affected limbs. However, little information is available regarding the necessary level of expression of VEGF and its possible related adverse effects. We have subcloned VEGF 165 isoform into pCMV-Script expression vector (Stratagene) under the control of the CMV promoter. Three patients with chronic ischaemia of the lower limb, considered as not suitable for surgical re-vascularization, received intramuscular injection with 0.5 ml saline solution containing 1011 copies of VEGF 165 plasmid. The clinical evolution has been monitored by angiography and estimated by walking time on the rolling carpet (Gardner protocol). Two months after therapy, all three patients showed complete relief of rest pain, improvement of ischaemic ulcer lesions and increased walking distance on the rolling carpet most probably due to appearance of newly formed collateral vessels.
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- 2007
46. Separate brain regions code for salience vs. valence during reward prediction in humans
- Author
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Irina Vitcu, Shitij Kapur, Jimmy Jensen, Adrian P. Crawley, Matthäus Willeit, David J. Mikulis, and Andrew J. A. Smith
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Adult ,Male ,Conditioning, Classical ,Models, Neurological ,Choice Behavior ,Brain mapping ,Basal Ganglia ,Reward ,Salience (neuroscience) ,Basal ganglia ,Avoidance Learning ,medicine ,Humans ,Radiology, Nuclear Medicine and imaging ,Valence (psychology) ,Research Articles ,Brain Mapping ,Radiological and Ultrasound Technology ,Ventral striatum ,Magnetic Resonance Imaging ,medicine.anatomical_structure ,nervous system ,Neurology ,Incentive salience ,Female ,Orbitofrontal cortex ,Neurology (clinical) ,Anatomy ,Aversive Stimulus ,Psychology ,Neuroscience - Abstract
Predicting rewards and avoiding aversive conditions is essential for survival. Recent studies using computational models of reward prediction implicate the ventral striatum in appetitive rewards. Whether the same system mediates an organism's response to aversive conditions is unclear. We examined the question using fMRI blood oxygen level‐dependent measurements while healthy volunteers were conditioned using appetitive and aversive stimuli. The temporal difference learning algorithm was used to estimate reward prediction error. Activations in the ventral striatum were robustly correlated with prediction error, regardless of the valence of the stimuli, suggesting that the ventral striatum processes salience prediction error. In contrast, the orbitofrontal cortex and anterior insula coded for the differential valence of appetitive/aversive stimuli. Given its location at the interface of limbic and motor regions, the ventral striatum may be critical in learning about motivationally salient stimuli, regardless of valence, and using that information to bias selection of actions. Inc. Hum Brain Mapp, 2007. © 2006 Wiley‐Liss, Inc.
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- 2007
47. Dicke-narrowed spectral line shapes of CO in Ar: Experimental results and a revised interpretation
- Author
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A. D. May, Franck Thibault, James R. Drummond, Roman Ciuryło, Richard Wehr, and A. Vitcu
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Physics ,Density matrix ,business.industry ,Inelastic collision ,Magnitude (mathematics) ,Noise (electronics) ,Atomic and Molecular Physics, and Optics ,Spectral line ,Spectral line shape ,Computational physics ,Optics ,Physical and Theoretical Chemistry ,business ,Constant (mathematics) ,Spectroscopy ,Line (formation) - Abstract
The shapes of Dicke-narrowed spectral lines in the fundamental P -branch of CO in Ar are studied by comparing high-resolution measurements and theoretical calculations. The measured spectra were recorded at temperatures between 214 and 324 K, and at pressures between 0.025 and 1 atm. The calculations are based on solving a transport/relaxation equation for the appropriate off-diagonal element of the density matrix; they use a realistic intermolecular potential to determine the speed-dependent collisional broadening, and a rigid sphere potential to determine the Dicke narrowing. It is found that the calculations can reproduce the measured spectra within the experimental noise under all conditions, but that the magnitude of the Dicke narrowing in the measured spectra is 70–90% less than predicted from the mass diffusion constant. A revised view of the collision operator resolves the discrepancy in principle, and leads to a better understanding of the line shape problem in general.
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- 2006
48. Collisional line shifting and broadening in the fundamental P-branch of CO in Ar between 214 and 324K
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Richard Wehr, Franck Thibault, James R. Drummond, A. Vitcu, and A. D. May
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Physics ,Density matrix ,business.industry ,Power law ,Noise (electronics) ,Atomic and Molecular Physics, and Optics ,Spectral line ,Spectral line shape ,Optics ,Potential energy surface ,Rigid sphere ,Physical and Theoretical Chemistry ,Atomic physics ,business ,Spectroscopy ,Line (formation) - Abstract
The collisional shifts and widths of several P -branch spectral lines in the fundamental band of CO–Ar have been measured at temperatures between 214 and 324 K and pressures between 0.025 and 1 atm. The widths have been determined using a line shape model based on the solution of the transport/relaxation equation for the appropriate off-diagonal element of the density matrix. The model uses a realistic molecular potential energy surface to calculate the speed dependence of the collisional broadening, and a rigid sphere potential to calculate the translational motion. It is found that both the shifting and broadening coefficients follow a power law dependence on the temperature. Additionally, it is demonstrated that studies have tended to overestimate the accuracy of collisional widths when the line shape model used to obtain the widths involves multiple fitted line shape parameters or fails to fit the measured spectra within the experimental noise.
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- 2006
49. Whole-body radiation dosimetry of 11C-carbonyl-URB694: a PET tracer for fatty acid amide hydrolase
- Author
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Junchao Tong, Irina Vitcu, Pablo Rusjan, Romina Mizrahi, Isabelle Boileau, Alan A. Wilson, Asfandyar Mufti, Stephen J. Kish, Sylvain Houle, and Peter M. Bloomfield
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Adult ,Male ,Amidohydrolases ,Image Processing, Computer-Assisted ,Medicine ,Humans ,Radiology, Nuclear Medicine and imaging ,In patient ,Tissue Distribution ,Whole Body Imaging ,Prospective Studies ,Pet tracer ,Radiometry ,Public Facility ,Border crossing ,business.industry ,Biphenyl Compounds ,Middle Aged ,medicine.disease ,Positron-Emission Tomography ,Female ,Medical emergency ,Carbamates ,Radiopharmaceuticals ,Nuclear medicine ,business ,Whole body ,Whole-Body Irradiation - Abstract
1993 Objectives To determine by a national survey: 1) the frequency of detection by public screening facilities of radioactivity in patients (pts) who had been treated with 131I for differentiated thyroid cancer (DTC), 2) the types and frequency of the various public facilities where pts were detected, and 3) the management of these pts by the security personnel. Methods Data were tabulated from a Thyroid Cancer Survivors Association, Inc. (ThyCa) website survey from November 2013 to December 2013 and was emailed to ~30,000 associates of ThyCa. Answers were tabulated of respondents (rpds) who reported that s/he 1) was >18 yo, 2) had at least one tx of 131I, and 3) was responding for his/her last 131I tx. The study was approved by the IRB. Results Of 334 rpds, 6.9% (23) attempted to pass through a public facility security checkpoint. Of these 23 pts all were detected and the detections occurred in an airport (7), border crossing (7), government building (3), shopping mall (3), train station (2), and steel recycling plant (1). The security personnel questioned 19 rpds, released 14 rpds without change in travel plans, rescanned 9 rpds, released 1 rpd with change in travel plans, and denied passage in 1 rpd. Security personnel verified the rpd’s 131I tx by examining an official document from the treating physician that was provided by 14 rpds, calling the treating facility regarding 3 rspds, and operating radiation detectors to identify the type and source of radiation in 2 rspds. Security personnel did not verify 131I tx in 4 rspds. Conclusions Public detection of radioactivity after 131I tx is infrequent, occurring in only 6.9% of respondents. Although airports and border crossings accounted for 61% of the sites of detection, the number of detected respondents was very low, and further respondents of the survey continue to be collected.
- Published
- 2014
50. Broadening, shifting, and line mixing in the 0310←0110 parallel Q branch of N2O
- Author
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James R. Drummond, A. D. May, Richard Wehr, Roman Ciuryło, and A. Vitcu
- Subjects
Physics ,Absorption spectroscopy ,Spectrometer ,Infrared ,Band gap ,business.industry ,Inelastic collision ,Atomic and Molecular Physics, and Optics ,Pressure range ,Optics ,Medium pressure ,Relaxation matrix ,Physical and Theoretical Chemistry ,Atomic physics ,business ,Spectroscopy - Abstract
The 03 1 0 ← 01 1 0 parallel Q branch of N 2 O has been studied at 297 K and over the pressure range 1–130 torr. Absorption spectra were recorded using a high resolution (1.5 MHz or 5 × 10 −5 cm −1 ) and high signal-to-noise (>3500:1) mid-infrared spectrometer based on difference-frequency infrared generation in AgGaS 2 . In the low-pressure range (1–11 torr) we obtained accurate values for the line strengths, the broadening coefficients, the weak mixing coefficients, and the overall shifting of the branch. The medium pressure results, ranging from 23 to 130 torr, were analyzed by treating the band as a whole, using a relaxation matrix formalism, based on an energy gap scaling law. We find, effectively, that only 36% of the rotationally inelastic collisions are associated with Q branch mixing, the rest presumably being associated with Q – P and Q – R mixing in the same vibrational band. The pressure shifting coefficient of the 03 1 0 ← 01 1 0 Q branch as a whole was also determined and found to be 5.8 × 10 −3 cm −1 /atm towards lower frequencies.
- Published
- 2004
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