Search

Your search keyword '"Vitcheva, Vessela"' showing total 161 results
Start Over Author "Vitcheva, Vessela"
161 results on '"Vitcheva, Vessela"'

14. Antidiabetic and antioxidant effects of saponarin from Gypsophila trichotoma on streptozotocin-induced diabetic normotensive and hypertensive rats

Author

Simeonova, Rumyana, Vitcheva, Vessela, Krasteva, Ilina, Zdraveva, Petranka, Konstantinov, Spiro, and Ionkova, Iliana

Subjects
Diabetes -- Care and treatment -- Research, Medicinal plants -- Physiological aspects -- Usage -- Research, Hypertension -- Care and treatment -- Research, Biological sciences, Health, Science and technology
Abstract

ABSTRACT Background: Diabetes and hypertension are diseases that often coexist, which increases the risk of chronic organ damages and cardiovascular complications. Purpose: To evaluate the effects of saponarin, isolated from [...]

Published
2016
Full Text
View/download PDF

18. Trans-3,5-dicaffeoylquinic acid from Geigeria alata Benth. & Hook.f. ex Oliv. & Hiern with beneficial effects on experimental diabetes in animal model of essential hypertension

Author

Simeonova, Rumyana, primary, Vitcheva, Vessela, additional, Zheleva-Dimitrova, Dimitrina, additional, Balabanova, Vessela, additional, Savov, Ionko, additional, Yagi, Sakina, additional, Dimitrova, Bozhana, additional, Voynikov, Yulian, additional, and Gevrenova, Reneta, additional

Published
2019
Full Text
View/download PDF

20. Development of a Protocol for Virtual Screening of PPARγ Weak Partial Agonists and Their Metabolites: Case Study on Naturally-derived Oleanane Triterpenoids.

Author

Sharif, Merilin Al, Alov, Petko, Vitcheva, Vessela, Diukendjieva, Antonia, Aluani, Denitsa, Tzankova, Virginia, and Pajeva, Ilza

Subjects
TRITERPENOIDS, METABOLITES, DIGITAL libraries
Abstract

Triterpenoids are well known metabolic syndrome (MetS) modulators. One of the suggested molecular mechanisms of action involves peroxisome proliferator-activated receptor gamma (PPARγ) activation. In this study we aimed to: (i) develop a virtual screening (VS) protocol for PPARγ weak partial agonists, (ii) predict potential metabolic transformations of naturally-derived triterpenoids, and (iii) perform VS of the triterpenoids and their metabolites. The NIH PubMed system was searched for publications about naturallyderived oleanane triterpenoids which are agonists or up-regulators of PPARγ. Structure- and ligand-based methods were combined in the development of the VS protocol. Metabolites were predicted using Meteor Nexus expert system (Lhasa Limited). Two in-house virtual libraries of PPARγ weak partial agonists and naturally-derived triterpenoids with their predicted metabolites were compiled. The pharmacophore-based docking protocol was applied for VS of the collected triterpenoids. Most of the docking poses reproduced the binding mode of caulophyllogenin (a weak partial agonist) in a complex with PPARγ (PDB ID 5F9B). Our results contribute to the mechanistic explanation of the effects of triterpenoids suggesting possible weak partial agonistic activity toward PPARγ. This research can direct further studies on triterpenoids’ role in MetS modulation. The developed protocol can be applied for VS of any PPARγ weak partial agonists. [ABSTRACT FROM AUTHOR]

Published
2021
Full Text
View/download PDF

24. Some In Vitro/In Vivo Chemically-Induced Experimental Models of Liver Oxidative Stress in Rats

Author

Simeonova, Rumyana, Kondeva-Burdina, Magdalena, Vitcheva, Vessela, and Mitcheva, Mitka

Subjects
Article Subject
Abstract

Oxidative stress is critically involved in a variety of diseases. Reactive oxygen species (ROS) are highly toxic molecules that are generated during the body's metabolic reactions and can react with and damage some cellular molecules such as lipids, proteins, or DNA. Liver is an important target of the oxidative stress because of its exposure to various prooxidant toxic compounds as well as of its metabolic function and ability to transform some xenobiotics to reactive toxic metabolites (as ROS). To investigate the processes of liver injuries and especially liver oxidative damages there are many experimental models, some of which we discuss further.

Published
2014
Full Text
View/download PDF

25. Modes-of-Action Related to Repeated Dose Toxicity: Tissue-Specific Biological Roles of PPARγ Ligand-Dependent Dysregulation in Nonalcoholic Fatty Liver Disease

Author

Al Sharif, Merilin, Alov, Petko, Vitcheva, Vessela, Pajeva, Ilza, and Tsakovska, Ivanka

Subjects
Article Subject
Abstract

Comprehensive understanding of the precise mode of action/adverse outcome pathway (MoA/AOP) of chemicals becomes a key step towards superseding the current repeated dose toxicity testing methodology with new generation predictive toxicology tools. The description and characterization of the toxicological MoA leading to non-alcoholic fatty liver disease (NAFLD) are of specific interest, due to its increasing incidence in the modern society. Growing evidence stresses on the PPARγ ligand-dependent dysregulation as a key molecular initiating event (MIE) for this adverse effect. The aim of this work was to analyze and systematize the numerous scientific data about the steatogenic role of PPARγ. Over 300 papers were ranked according to preliminary defined criteria and used as reliable and significant sources of data about the PPARγ-dependent prosteatotic MoA. A detailed analysis was performed regarding proteins which PPARγ-mediated expression changes had been confirmed to be prosteatotic by most experimental evidence. Two probable toxicological MoAs from PPARγ ligand binding to NAFLD were described according to the Organisation for Economic Cooperation and Development (OECD) concepts: (i) PPARγ activation in hepatocytes and (ii) PPARγ inhibition in adipocytes. The possible events at different levels of biological organization starting from the MIE to the organ response and the connections between them were described in details.

Published
2014
Full Text
View/download PDF

30. Protective Effects of Saponin Mixture, Isolated from <i>Astragalus monspessulanus</i> subsp. <i>monspessulanus</i> on Tert-Butyl Hydroperoxide—Induced Oxidative Stress in Isolated Rat Hepatocytes

Author

Kondeva-Burdina, Magdalena Spasova, primary, Bratkov, Viktor, additional, Simeonova, Rumyana Lubomirova, additional, Vitcheva, Vessela Bisserova, additional, Krasteva, Ilina Nikolaeva, additional, and Zdraveva, Petranka Krumova, additional

Published
2015
Full Text
View/download PDF

36. Development of new COSMOS oRepeatDose and non-cancer Threshold of Toxicological Concern (TTC) databases to support alternative testing methods for cosmetics related chemicals

Author

Yang, Chihae, primary, Ambrosio, Massimo, additional, Arvidson, Kirk, additional, Barlow, Sue, additional, Boobis, Alan, additional, Checheva, Maria, additional, Cronin, Mark, additional, Felter, Susan, additional, Fioravanzo, Elena, additional, Hollnagel, Heli, additional, Hristozov, Dimitar, additional, Jacobs, Kristi, additional, Keller, Detlef, additional, Mostrag-Szylchtying, Aleksandra, additional, Nelms, Mark, additional, Rathman, James, additional, Richarz, Andrea, additional, Tsakovska, Ivanka, additional, Vidry, Stephane, additional, Vitcheva, Vessela, additional, and Worth, Andrew, additional

Published
2013
Full Text
View/download PDF

39. TTC Task Force: Development of a cosmetics database to support application of TTC to cosmetic ingredients (EU Cosmos project)

Author

Hollnagel, Helli M., primary, Ambrosio, Massimo, additional, Boobis, Alan R., additional, Cronin, Mark, additional, Felter, Susan P., additional, Keller, Detlef, additional, Jacobs, K.L. Muldoon, additional, Safford, R., additional, Vitcheva, Vessela, additional, Worth, Andrew P., additional, and Yang, Chihae, additional

Published
2013
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results