22,753 results on '"Vitamin b complex"'
Search Results
2. School-Based Assessment of Micronutrient Interventions in Adolescents in Burkina Faso (SAMIA)
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Centre de Recherche en Sante de Nouna, Burkina Faso and Wafaie Fawzi, Professor of Nutrition, Epidemiology, and Global Health
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- 2024
3. B-Complex: A Nutraceutical SANS Countermeasure
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Mayo Clinic, Texas A&M University, and Sara R. Zwart, PhD, Deputy Manager for Nutritional Biochemistry
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- 2024
4. Testing the Use of Combination Immunotherapy Treatment (N-803 [ALT-803] Plus Pembrolizumab) Against the Usual Treatment for Advanced Non-small Cell Lung Cancer (A Lung-MAP Treatment Trial)
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National Cancer Institute (NCI)
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- 2024
5. The Efficacy of B6 and Metoclopramide Combination in Comparison With the Other Antiemetics
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Hashim Talib Hashim, Principal investigator
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- 2024
6. Acceptability and Nutritional Impact of Double-fortified Salt Containing Iodine and Folic Acid (DFS-IoFA-2)
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Ethiopian Public Health Institute, University of California, San Francisco, University of Rhode Island, Nutrition International, and Kenneth H. Brown, MD, Distinguished Professor Emeritus
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- 2024
7. Levocarnitine and Vitamin B Complex in Treating PEG-Asparaginase or Inotuzumab Ozogamicin-Induced Hyperbilirubinemia in Patients With Acute Lymphoblastic Leukemia
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National Cancer Institute (NCI)
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- 2024
8. Vitamin B6 in Reducing Hot Flashes in Participants With Prostate Cancer Undergoing Antiandrogen Therapy
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- 2024
9. Vitamin B6 on Exercise Pressor Reflex on Leg Ischemia-reperfusion
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American Heart Association and Lu Qin, Assistant Professor in Department of Medicine
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- 2024
10. Effects of Supplementation of Compound Nutrients on Plasma Homocysteine in Chinese Adults
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Huilian Zhu, Sun Yat-sen University
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- 2024
11. Alpha-lipoic Acid Combined With B Vitamins Shows Promise for Treating Restless Legs Syndrome
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- 2024
12. Tuberculosis Preventive Therapy Among Latent Tuberculosis Infection in HIV-infected Individuals
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King Chulalongkorn Memorial Hospital, Police General Hospital, Pranangklao Hospital, Taksin Hospital, Bhumibol Adulyadej Hospital, Klang Hospital, Chiang Rai Prachanukroh Hospital, Sanpatong Hospital, Queen Sawang Vadhana Memorial Hospital, Buddhachinnaraj Hospital, Maharat Nakhon Ratchasima Hospital, HatYai Hospital, Srinagarind Hospital, Khon Kaen University, Sisaket Hospital, and The Public Health Centre 28 Krung thon buri
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- 2024
13. Vitamin B12 Dose Escalation Trial in Pregnancy (MM4MN-B12)
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Ifakara Health Institute and Emily Smith, PI
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- 2024
14. Niacin for Parkinsons Disease (NAPS)
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- 2024
15. Nutritional value, phytochemical composition, and antioxidant potential of Iranian fenugreeks for food applications.
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Bakhtiar, Ziba, Hassandokht, Mohammadreza, Naghavi, Mohammad Reza, and Mirjalili, Mohammad Hossein
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NUTRITIONAL value , *VITAMIN C , *VITAMIN B complex , *FLAVONOIDS , *ESSENTIAL oils , *PHYTOCHEMICALS - Abstract
Fenugreeks (Trigonella L. spp.), are well-known herbs belonging to the family Fabaceae, whose fresh and dried leaves have nutritional and medicinal value. In the present study, the content of phytochemical traits (essential oil, diosgenin, trigonelline, total phenol, total flavonoid, total saponins, and total tannins), bitterness value, pigments (chlorophyll, carotenoid, β-carotene, and anthocyanin), vitamins (group B vitamins and ascorbic acid), minerals, and antioxidant activity of thirty cultivated populations belonging to ten Trigonella species were evaluated. The species and populations were significantly different in all studied parameters. A significant positive and negative correlation (p < 0.05) was also observed between the studied parameters. In total, T. teheranica, T. elliptica, and T. foenum-graecum were distinguished as superior species. The results showed that fenugreeks leaves can be considered as a valuable source of food and phytochemical compounds. The obtained data can be help to expand the inventory of wild and cultivated Trigonella species for further exploitation of rich chemotypes in the new foods and specific applications. [ABSTRACT FROM AUTHOR]
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- 2024
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16. Review of physiological compounds and health benefits of soybean paste (doenjang): exploring its bioactive components.
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Park, Young Kyoung, Kim, Jinwon, Ryu, Myeong Seon, Jeong, Do-Youn, and Yang, Hee-Jong
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MISO ,SOYBEAN products ,KOREAN cooking ,VITAMIN B complex ,BACILLUS cereus - Abstract
This review paper explores the history, cultural significance, and functional characteristics of soybean paste (doenjang) in Korean cuisine. In particular, it covers its origins, cultural importance, production methods, functionalities, and associated risks. This review delves into the nutritional and functional aspects of fermented soybean products, focusing on compounds in soybean paste linked to health benefits, such as anticancer, anti-obesity, anti-diabetic, and antithrombotic properties. The key bioactive compounds identified in soybean paste include total phenols, total flavonoids, γ-Aminobutyric acid, vitamin B group, and vitamin E. These compounds are primarily produced through microbial fermentation, which enhances their biological activity. Additionally, the review addresses potential risks such as biogenic amines, aflatoxins, Bacillus cereus contamination, and high sodium levels, and suggests methods for mitigating these risks. By synthesizing current research, this paper aims to provide a comprehensive understanding of the physiological compounds in soybean paste and their health benefits. It also highlights the need for strategies to reduce associated risks. [ABSTRACT FROM AUTHOR]
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- 2024
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17. Corrin Ring Modifications Reveal the Chemical and Spatial Requirements for the B12‐btuB Riboswitch Interaction.
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Musiari, Anastasia, Reichenbach, María, Gallo, Sofia, and Sigel, Roland K. O.
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MEMBRANE transport proteins , *VITAMIN B12 , *NUCLEOTIDE sequence , *VITAMIN B complex , *GENE expression - Abstract
The btuB riboswitch is a regulatory RNA sequence controlling gene expression of the outer membrane B12 transport protein BtuB by specifically binding coenzyme B12 (AdoCbl) as its natural ligand. The B12 sensing riboswitch class is known to accept various B12 derivatives, leading to a division into two riboswitch subclasses, dependent on the size of the apical ligand. Here we focus on the role of side chains b and e on affinity and proper recognition, i. e. correct structural switch of the btuB RNA, which belongs to the AdoCbl‐binding class I. Chemical modification of these side chains disturbs crucial hydrogen bonds and/or electrostatic interactions with the RNA, its effect on both affinity and switching being monitored by in‐line probing. Chemical modifications at sidechain b of vitamin B12 show larger effects indicating crucial B12‐RNA interactions. When introducing the same modification to AdoCbl the influence of any side‐chain modification tested is reduced. This renders the impact of the adenosyl‐ligand for B12‐btuB riboswitch recognition clearly beyond the known role in affinity. [ABSTRACT FROM AUTHOR]
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- 2024
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18. Unveiling the Therapeutic Potential of Folate-Dependent One-Carbon Metabolism in Cancer and Neurodegeneration.
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Sobral, Ana Filipa, Cunha, Andrea, Silva, Vera, Gil-Martins, Eva, Silva, Renata, and Barbosa, Daniel José
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ALZHEIMER'S disease , *VITAMIN B complex , *DNA synthesis , *NEURAL tube , *PARKINSON'S disease , *FOLIC acid - Abstract
Cellular metabolism is crucial for various physiological processes, with folate-dependent one-carbon (1C) metabolism playing a pivotal role. Folate, a B vitamin, is a key cofactor in this pathway, supporting DNA synthesis, methylation processes, and antioxidant defenses. In dividing cells, folate facilitates nucleotide biosynthesis, ensuring genomic stability and preventing carcinogenesis. Additionally, in neurodevelopment, folate is essential for neural tube closure and central nervous system formation. Thus, dysregulation of folate metabolism can contribute to pathologies such as cancer, severe birth defects, and neurodegenerative diseases. Epidemiological evidence highlights folate's impact on disease risk and its potential as a therapeutic target. In cancer, antifolate drugs that inhibit key enzymes of folate-dependent 1C metabolism and strategies targeting folate receptors are current therapeutic options. However, folate's impact on cancer risk is complex, varying among cancer types and dietary contexts. In neurodegenerative conditions, including Alzheimer's and Parkinson's diseases, folate deficiency exacerbates cognitive decline through elevated homocysteine levels, contributing to neuronal damage. Clinical trials of folic acid supplementation show mixed outcomes, underscoring the complexities of its neuroprotective effects. This review integrates current knowledge on folate metabolism in cancer and neurodegeneration, exploring molecular mechanisms, clinical implications, and therapeutic strategies, which can provide crucial information for advancing treatments. [ABSTRACT FROM AUTHOR]
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- 2024
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19. Comparative Study of the Healing Process of Disbudding Wounds in Calves Using Bepanthene ® or an Antibiotic Spray.
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Martins, Gabriela and Stilwell, George
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VITAMIN B complex , *PANTOTHENIC acid , *WOUND healing , *SKIN regeneration , *GRANULATION tissue - Abstract
Simple Summary: Antimicrobial resistance is seen as a global threat to One Health, since it is associated with high rates of morbidity and mortality. To reduce the use of antimicrobials in farm animals, Bepanthene® was compared with an antibiotic-based spray in the healing of disbudding wounds in calves. Benpanthene® is based on dexpanthenol, a derivative of pantothenic acid, also known as provitamin B5, which protects and stimulates skin regeneration. The findings of the present study support the use of Bepanthene®, allowing for a reduction in the use of antimicrobials in production animals without impeding healing. The process of disbudding female calves is a common procedure in many dairy farms, avoiding injuries caused by horns and reducing feed bunk space requirements. The most common method for disbudding calves is by the use of a cautery iron, responsible for destroying the horn-generating tissue. After the procedure, wounds may be treated with an antibiotic-based spray. Nowadays, antimicrobial resistance is a worldwide concern in both human and veterinary medicine, highlighting the need to invest in the monitoring of antimicrobial use and in the development of alternative treatments in favour of One Health. The goal of this study is to promote a reduction in the use of antibiotics in farm animals by investigating an alternative treatment for disbudding wounds. Bepanthene® (dexpanthenol, a derivative of pantothenic acid, a component of the B vitamin complex) is a plausible option, since it is widely used in human medicine for the treatment of skin irritations and burns. The comparison of the healing process of disbudding wounds treated with Bepanthene® or a chlortetracycline-based spray was achieved through the presentation of a randomly-ordered sequence of images of the lesions to a panel of convenience-selected and blinded-to-treatment evaluators, composed of seven veterinarian practitioners, five veterinary medicine students, and five human medical field nurses. In order to classify the lesions, the panel applied an adapted format of a validated healing scale (Bates–Jensen Wound Assessment Tool), incorporating seven parameters of evaluation, culminating in the values used for statistical analyses. In the practitioners' evaluation, a statistically significant effect for the factors of time and treatment in favour of Bepanthene® was found for the parameters "Edges", "Necrotic Tissue Type", and "Skin Colour Surrounding Wound", indicating that Bepanthene® is superior to the spray when considering these parameters of healing. The assessment by the veterinary students showed a significant effect for the factors of time and treatment for the parameters "Necrotic Tissue Type", in favour of the Bepanthene®, and "Granulation Tissue", in favour of the antibiotic spray, demonstrating no clear benefit for either treatment. Lastly, the evaluation performed by nurses showed a significant effect for the factors of time and treatment, in favour of the Bepanthene®, for the parameters "Necrotic Tissue Type" and "Skin Colour Surrounding Wound", leading to the conclusion that Bepanthene® is associated with better and faster healing when compared to the spray. Overall, these findings lead us to suggest that Bepanthene® presents a better healing index compared to a chlortetracycline-based spray, allowing it to be safely used as a substitute to an antimicrobial agent. [ABSTRACT FROM AUTHOR]
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- 2024
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20. An injectable biomimetic hydrogel adapting brain tissue mechanical strength for postoperative treatment of glioblastoma without anti-tumor drugs participation.
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Jia, Mengqi, Zhou, Xiaodong, Li, Pengfei, and Zhang, Shiyong
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FOREIGN body reaction , *LIPOIC acid , *VITAMIN B complex , *CEREBRAL edema , *EXTRACELLULAR fluid - Abstract
Adapting the mechanical strength between the implant materials and the brain tissue is crucial for the postoperative treatment of glioblastoma. However, no related study has been reported. Herein, we report an injectable lipoic acid‑iron (LA-Fe) hydrogel (LFH) that can adapt to the mechanical strength of various brain tissues, including human brain tissue, by coordinating Fe3+ into a hybrid hydrogel of LA and its sodium salt (LANa). When LFH, which matches the mechanical properties of mouse brain tissue (337 ± 8.06 Pa), was injected into the brain resection cavity, the water content of the brain tissue was maintained at a normal level (77%). Similarly, LFH did not induce the activation or hypertrophy of glial astrocytes, effectively preventing brain edema and scar hyperplasia. Notably, LFH spontaneously degrades in the interstitial fluid, releasing LA and Fe3+ into tumor cells. The redox couples LA/DHLA (dihydrolipoic acid, reduction form of LA in cells) and Fe3+/Fe2+ would regenerate each other to continuously provide ROS to induce ferroptosis and activate immunogenic cell death. As loaded the anti-PDL1, anti-PDL1@LFH further enhanced the efficacy of tumor-immunotherapy and promoted tumor ferroptosis. The injectable hydrogel that adapted the mechanical strength of tissues shed a new light for the tumor postoperative treatment. TOC Graph: The first injectable hydrogel that can adapt the mechanical strength of different brain tissues including human brain has been developed for the GBM postoperative treatment without the involvement of anti-tumor drugs by coordinating Fe3+ into the hybrid hydrogel of B vitamin lipoic acid (LA) and its sodium salt (LANa). [Display omitted] • By coordinating Fe3+ into the hybrid hydrogel of lipoic acid (LA) and its sodium salt (LANa) formed an injectable hydrogel. • The LA-Fe hydrogel (LFH) can adapt the mechanical strength of multiple brain tissues including human brain. • The LFH circumvented the foreign body reaction caused by material implantation, and effectively inhibited tumor recurrence. • As loaded the anti-PDL1, anti-PDL1@LFH further enhanced the tumor-immunotherapy efficacy and promoted the tumor ferroptosis. [ABSTRACT FROM AUTHOR]
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- 2024
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21. Blocking proteinase-activated receptor 2 signaling relieves pain, suppresses nerve sprouting, improves tissue repair, and enhances analgesic effect of B vitamins in rats with Achilles tendon injury.
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Lihui Li, Hongyu Yao, Rufan Mo, Lihong Xu, Peng Chen, Yuchen Chen, Jiang-Jian Hu, Wei Xie, and Xue-Jun Song
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VITAMIN B complex , *ACHILLES tendon rupture , *ACHILLES tendon , *DORSAL root ganglia , *SMALL interfering RNA - Abstract
Tendon injury produces intractable pain and disability in movement, but the medications for analgesia and restoring functional integrity of tendon are still limited. In this study, we report that proteinase-activated receptor 2 (PAR2) activation in dorsal root ganglion (DRG) neurons contributes to chronic pain and tendon histopathological changes produced by Achilles tendon partial transection injury (TTI). Tendon partial transection injury increases the expression of PAR2 protein in both somata of DRG neurons and their peripheral terminals within the injured Achilles tendon. Activation of PAR2 promotes the primary sensory neuron plasticity by activating downstream cAMP-PKA pathway, phosphorylation of PKC, CaMKII, and CREB. Blocking PAR2 signaling by PAR2 small-interference RNA or antagonistic peptide PIP delays the onset of TTI-induced pain, reverses the ongoing pain, as well as inhibits sensory nerve sprouting, and promotes structural remodeling of the injured tendon. Vitamin B complex (VBC), containing thiamine (B1), pyridoxine (B6), and cyanocobalamin (B12), is effective to ameliorate TTI-induced pain, inhibit ectopic nerve sprouting, and accelerate tendon repair, through suppressing PAR2 activation. These findings reveal a critical role of PAR2 signaling in the development of chronic pain and histopathological alterations of injured tendon following Achilles tendon injury. This study suggests that the pharmaceuticals targeting PAR2, such as VBC, may be an effective approach for the treatment of tendon injury-induced pain and promoting tendon repair. [ABSTRACT FROM AUTHOR]
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- 2024
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22. Impact of oligosaccharides on probiotic properties and B vitamins production: a comprehensive assessment of probiotic strains.
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Yin, Jia, Peng, Xiaoxia, Yang, Aijun, Lin, Mudi, Ji, Kunfa, Dai, Xiaohui, Huang, Juan, Li, Li, and Feng, Like
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VITAMIN B deficiency , *VITAMIN B complex , *PROBIOTICS , *OLIGOSACCHARIDES , *FUNCTIONAL foods , *BIOFILMS - Abstract
Summary: From recent literature and research studies, it has been found that some bacterial strains have abilities with probiotic activities to produce B vitamins, which play essential roles in maintaining human health. Oligosaccharides can promote the beneficial microbes, however, the specific effects of oligosaccharides on B vitamins‐producing ability of probiotic strains have not been clarified. This study evaluated the effect of different oligosaccharides on the probiotic properties and B vitamin‐producing ability of 21 selected probiotic strains. The obtained results suggested that the strains could utilise oligosaccharides as the sole carbon source, and the hydrophobicity, auto‐aggregation, and biofilm formation of probiotic strains were specific regulated after fermentation with different oligosaccharides. In particular, the oligosaccharides had different influences on the levels of extracellular B vitamins produced by probiotic strains. These findings provide the foundation for studies on the B vitamins‐producing probiotic strains and their application in functional foods to prevent B vitamins deficiency. [ABSTRACT FROM AUTHOR]
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- 2024
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23. B vitamins and bone health: a meta-analysis with trial sequential analysis of randomized controlled trials.
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Luo, Yan, Zheng, Shengyuan, Jiang, Shide, Yang, Guang, Pavel, Volotovski, Ji, Haoran, Zhou, Shujie, Bao, Yunong, Xiao, Wenfeng, and Li, Yusheng
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OSTEOPOROSIS prevention , *THERAPEUTIC use of vitamin B12 , *THERAPEUTIC use of folic acid , *BONE fracture prevention , *MEDICAL information storage & retrieval systems , *STATISTICAL models , *BONE resorption , *BONE density , *RESEARCH funding , *VITAMIN B complex , *META-analysis , *CHI-squared test , *RELATIVE medical risk , *ALKALINE phosphatase , *DESCRIPTIVE statistics , *BONE fractures , *SYSTEMATIC reviews , *MEDLINE , *SERUM , *FEMUR neck , *VITAMIN B6 , *DRUG efficacy , *MEDICAL databases , *LUMBAR vertebrae , *ONLINE information services , *DATA analysis software , *CONFIDENCE intervals , *OSTEOPOROSIS , *DIETARY supplements , *BIOMARKERS , *DISEASE incidence , *DISEASE risk factors - Abstract
Summary: Our study showed that B vitamins did not have significant effect on fracture incidence, bone mineral density, and bone turnover markers. However, the research data of B vitamins on bone mineral density and bone turnover markers are limited, and more clinical trials are needed to draw sufficient conclusions. Purpose: The objective of this study was to identify the efficacy of B vitamin (VB) (folate, B6, and B12) supplements on fracture incidence, bone mineral density (BMD), and bone turnover markers (BTMs). Methods: A comprehensive search was performed in PubMed, MEDLINE, EMBASE, Cochrane databases, and ClinicalTrials.gov up to September 4, 2023. The risk of bias was assessed according to Cochrane Handbook and the quality of evidence was assessed according to the GRADE system. We used trial sequential analysis (TSA) to assess risk of random errors and Stata 14 to conduct sensitivity and publication bias analyses. Results: Data from 14 RCTs with 34,700 patients were extracted and analyzed. The results showed that VBs did not significantly reduce the fracture incidence (RR, 1.06; 95% CI, 0.95 − 1.18; p = 0.33; I2 = 40%) and did not affect BMD in lumbar spine and femur neck. VBs had no significant effect on bone specific alkaline phase (a biomarker for bone formation), but could increase the serum carboxy-terminal peptide (a biomarker for bone resorption) (p = 0.009; I2 = 0%). The TSA showed the results of VBs on BMD and BTMs may not be enough to draw sufficient conclusions due to the small number of sample data included and needed to be demonstrated in more clinical trials. The inability of VBs to reduce fracture incidence has been verified by TSA as sufficient. Sensitivity analysis and publication bias assessment proved that our meta-analysis results were stable and reliable, with no significant publication bias. Conclusions: Available evidence from RCTs does not support VBs can effectively influence osteoporotic fracture risk, BMD, and BTMs. Trial registration: PROSPERO registration number: CRD42023427508. [ABSTRACT FROM AUTHOR]
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- 2024
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24. Effect of dietary protein source and Saccharina latissima on nutritional and safety characteristics of milk.
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Wang, Bing, Ormston, Sabrina, Płatosz, Natalia, Parker, Jane K, Qin, Nanbing, Humphries, David J, Pétursdóttir, Ásta H, Halmemies‐Beauchet‐Filleau, Anni, Juniper, Darren T, and Stergiadis, Sokratis
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DISTILLERY by-products , *SATURATED fatty acids , *DIETARY proteins , *RAPESEED meal , *VITAMIN B complex - Abstract
BACKGROUND: Wheat distillers' grains (WDG) and seaweeds are recommended as alternative protein sources and enteric methane mitigators in dairy cow diets, respectively, but little is known about their impact on milk quality and safety. In the present study, 16 cows in four 4 × 4 Latin squares were fed isonitrogenous diets (50:50 forage:concentrate ratio), with rapeseed meal (RSM)‐based or WDG‐based concentrate (230 and 205 g kg−1 dry matter) and supplemented with or without Saccharina latissima. RESULTS: Replacement of RSM with WDG enhanced milk nutritional profile by decreasing milk atherogenicity (P = 0.002) and thrombogenicity (P = 0.019) indices and the concentrations of the nutritionally undesirable saturated fatty acids – specifically, lauric (P = 0.045), myristic (P = 0.022) and palmitic (P = 0.007) acids. It also increased milk concentrations of the nutritionally beneficial vaccenic (P < 0.001), oleic (P = 0.030), linoleic (P < 0.001), rumenic (P < 0.001) and α‐linolenic (P = 0.012) acids, and total monounsaturated (P = 0.044), polyunsaturated (P < 0.001) and n‐6 (P < 0.001) fatty acids. Feeding Saccharina latissima at 35.7 g per cow per day did not affect the nutritionally relevant milk fatty acids or pose any risk on milk safety, as bromoform concentrations in milk were negligible and unaffected by the dietary treatments. However, it slightly reduced milk concentrations of pantothenate. CONCLUSION: Feeding WDG to dairy cows improved milk fatty acid profiles, by increasing the concentrations of nutritionally beneficial fatty acids and reducing the concentration of nutritionally undesirable saturated fatty acids, while feeding seaweed slightly reduced pantothenate concentrations. However, when considering the current average milk intakes in the population, the milk compositional differences between treatments in this study appear relatively small to have an effect on human health. © 2024 The Authors. Journal of The Science of Food and Agriculture published by John Wiley & Sons Ltd on behalf of Society of Chemical Industry. [ABSTRACT FROM AUTHOR]
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- 2024
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25. Pharmacologic management of trigeminal nerve injury after endodontic treatment: A retrospective analysis.
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Park, Keun Jeong, Choi, Eunhye, Jung, Il Young, and Kim, Seong Taek
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STEROIDS , *NONSTEROIDAL anti-inflammatory agents , *CUTANEOUS therapeutics , *COMBINATION drug therapy , *ACADEMIC medical centers , *ADENOSINE triphosphate , *TRIGEMINAL nerve , *TREATMENT effectiveness , *RETROSPECTIVE studies , *DESCRIPTIVE statistics , *VITAMIN B complex , *NUMBNESS , *ANTIDEPRESSANTS , *ROOT canal treatment , *MEDICAL records , *ACQUISITION of data , *NARCOTICS , *COMPARATIVE studies , *MAXILLARY nerve , *LIDOCAINE , *ANTICONVULSANTS - Abstract
Background: Trigeminal nerve injury following endodontic treatment, leading to unpleasant sensations or partial sensory loss in the face or oral mucosa, is uncommon but significant when it occurs. Objective: This study analysed the pharmacological management of trigeminal nerve injuries (TNI) in a university‐based hospital. Methods: We conducted a retrospective analysis of 47 patients who visited the Department of Orofacial Pain and Oral Medicine at Yonsei University Dental Hospital, Seoul, Korea, after TNI following endodontic procedures in primary clinics. Both objective tests and subjective evaluations, assessed the extent and duration of sensory injury during the initial visit. The patient's initial symptoms, presumed cause of TNI, referral delay (time interval between TNI and the first visit to our clinic), and medications were analysed to determine whether these factors affected the outcomes. Results: Most patients with TNI experienced dysesthesia with hypoesthesia (70.2%). The mandibular molars were predominantly affected (72.3%), with the inferior alveolar nerve (IAN), lingual nerve (LN), both IAN and LN, and maxillary nerve compromised in 83.0, 12.8, 2.1, and 2.1% of cases, respectively. Causes of TNI included local anaesthesia (29.8%), overfilling/over‐instrumentation (25.5%), endodontic surgery (17.0%), and unknown factors (27.7%). A shorter referral delay was associated with better outcomes, with an average delay of 8.6 weeks for symptom improvement compared with 44.1 weeks for no change. The medication regimens included steroids, NSAIDs, topical lidocaine, vitamin B complex, Adenosine Triphosphate (ATP), antiepileptics, antidepressants, and opioids administered alone or in combination, with a mean duration of 20.7 weeks. 53.2% of the patients reported improvement in their symptoms, 27.7% experienced no significant change, and 19.1% had unknown outcomes. Conclusions: Swift referral to an orofacial pain specialist is recommended for effective recovery in cases of TNI arising from endodontic treatment. [ABSTRACT FROM AUTHOR]
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- 2024
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26. Real-world experience with clinical management of talquetamab in relapsed/refractory multiple myeloma: a qualitative study of US healthcare providers.
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Schinke, Carolina, Dhakal, Binod, Mazzoni, Sandra, Shenoy, Samantha, Scott, Sara A., Richards, Tiffany, Le, Hoa H., DeBrosse, Amalia, Okorozo, Peter, McDowell, Rachel, Patel, Saurabh, Bunn, Jonathan, Hawks, Kelly, Zhang, Xinke, and Rodriguez, Cesar
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VITAMIN B complex , *MEDICAL personnel , *BISPECIFIC antibodies , *THERAPEUTICS , *MULTIPLE myeloma - Abstract
AbstractObjectiveMethodsResultsConclusion\nPLAIN LANGUAGE SUMMARYTalquetamab is the first-in-class GPRC5DxCD3 bispecific antibody for relapsed/refractory multiple myeloma. Given limited real-world data, this study was conducted with US healthcare providers (HCPs) to understand real-world talquetamab dosing and symptom management.In February/March 2024, individual in-depth interviews (IDIs;
n = 10) were conducted with HCPs administering talquetamab in real-world settings. A subsequent expert panel (n = 6) further discussed current practices.The IDIs reported a variety of settings for step-up dosing (SUD), including inpatient (n = 5), outpatient (n = 3), and hybrid models (n = 2), with a trend toward shorter SUD length to reduce healthcare resource utilization. Most HCPs used a biweekly (Q2W) schedule in SUD (n = 7) and treatment phases (n = 8). Six participants explored reducing dose frequency to every 4 weeks (Q4W) in patients following positive disease response to treatment, considering patient convenience and relieving GPRC5D-related symptoms. Panelists recommended symptom management and prophylactic strategies, such as dexamethasone and nystatin mouthwash or zinc and vitamin B complex for oral symptoms, and topical steroids and cosmetic products for skin and nail symptoms.This study outlines current real-world practices for talquetamab. Findings indicate variation in the SUD care setting. The 0.8 mg/kg Q2W dosing schedule was most common, although switching to Q4W is a real-world symptom management strategy for some patients with responses to therapy. GPRC5D-related symptom management approaches are evolving; prophylactic use of dexamethasone and nystatin mouthwash or zinc and vitamin B complex may be effective strategies to alleviate oral symptoms. Further real-world evidence is needed to inform optimal dosing schedules while mitigating symptom impact.Talquetamab is a new treatment that was approved in the United States in 2023 for a type of blood cancer called multiple myeloma. This drug is administered at one of two doses, each of which includes a defined step-up dosing schedule where patients first receive smaller amounts of the drug to help avoid serious side effects. Because talquetamab is new and associated with treatment-related symptoms not normally seen with other multiple myeloma treatments, doctors and patients need more guidance on drug administration and symptom management. In this study, we describe findings from interviews and an expert panel discussion with healthcare professionals who have experience using talquetamab. This study found that most healthcare professionals administered step-up dosing with patients staying overnight in the hospital, while other providers administered these doses during outpatient visits. Most providers administered talquetamab once every 2 weeks after utilizing the associated step-up dosing schedule. Additionally, healthcare providers described transitioning some patients, who had responded positively to treatment, to a less frequent dosing schedule of once per month to help reduce the effect of treatment-related symptoms. Participants in the expert panel described approaches for managing or preventing these symptoms, such as dexamethasone and nystatin mouthwashes or zinc and vitamin B complex for oral symptoms, and topical steroids and cosmetic products for skin and nail symptoms. In summary, this study provides valuable real-world information from healthcare providers who have experience treating patients with multiple myeloma with talquetamab. [ABSTRACT FROM AUTHOR]- Published
- 2024
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27. The Effect of Phototherapy on Systemic Inflammation Measured with Serum Vitamin D-Binding Protein and hsCRP in Patients with Inflammatory Skin Disease.
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Elmelid, Andrea, Vandikas, Maria Siekkeri, Gillstedt, Martin, Alsterholm, Mikael, and Osmancevic, Amra
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VITAMIN D deficiency , *ATOPIC dermatitis , *VITAMIN B complex , *CARRIER proteins , *SKIN diseases , *VITAMIN D receptors - Abstract
Vitamin D plays a role in inflammatory skin disease, but the exact mechanisms and the clinical significance remain unclear. According to the free hormone hypothesis, it is the free concentration of 25-hydroxy vitamin D (25(OH)D) that is biologically active. Vitamin D-binding protein (DBP) acts as the major transporter of vitamin D in the circulation, and DBP concentration defines the free 25(OH)D levels. DBP levels are elevated in various inflammatory conditions, including psoriasis. Narrowband-ultraviolet B (NB-UVB) is the most widely used phototherapy and is an established first-line treatment for psoriasis and atopic dermatitis (AD), often used before proceeding to systemic treatment. The aim of this study was to investigate the influence of NB-UVB phototherapy on DBP and high-sensitivity C-reactive protein (hsCRP) levels, as markers of systemic inflammation, in inflammatory skin disease. Thirty adults (psoriasis (n = 20) and AD (n = 10)) were treated with NB-UVB. Serum DBP, hsCRP, total and free 25(OH)D, and 1,25-dihydroxy vitamin D (1,25(OH)2D) were measured before and after NB-UVB. Disease severity was assessed with Psoriasis Area and Severity Index (PASI), SCORing Atopic Dermatitis (SCORAD), and Visual Analogue Scale (VAS). DBP decreased in psoriasis patients and varied with no clear trend in AD patients. HsCRP decreased in both groups, but this did not reach statistical significance. PASI, SCORAD, and VAS improved, and vitamin D levels increased after NB-UVB. Sub-analysis indicated a better response to NB-UVB for patients with vitamin D deficiency and insufficiency compared to vitamin D-sufficient patients. The decrease in DBP after NB-UVB in psoriasis patients suggests a potential systemic anti-inflammatory effect of phototherapy. Measurement of vitamin D levels may potentially serve as a tool to identify patients who would derive the greatest benefit from NB-UVB phototherapy. [ABSTRACT FROM AUTHOR]
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- 2024
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28. Assessment of Nutritional Quality of Plant-based Meat Alternatives Sold in the Philippines.
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Pagulayan, Jin Mark D. G., Tolentino, Mark Paulo S., Anapi, Gerieka R., Basinang, Airisse Rae P., and Villarino, Casiana Blanca J.
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NUTRITIONAL assessment , *MEAT alternatives , *VITAMIN B complex , *MEAT quality , *GROUND meat , *DIETARY fiber , *SAUSAGES , *BACON - Abstract
Plant-based meat alternatives (PBMAs) have been included in Filipino’s diet since their availability in the Philippines, making it important to evaluate their nutritional profile to assist consumers in purchase and consumption decisions. This study identified various PBMAs in Metro Manila, Bulacan, and Pampanga. Information based on the labels of PBMAs and animal-based meats (ABM) was collected and evaluated. PBMAs (n = 37) included chicken products (n = 4), ground meat (n = 5), patties and sausages (n = 19), jerkies (n = 4), and others [i.e. tocino (Philippine sweet bacon), luncheon meat, and belly rolls]. PBMAs generally have lower energy, total and saturated fat, and higher price/g protein, dietary fiber, sodium, and calcium content compared to ABM. Proteins, carbohydrates, and other micronutrients (i.e. iron, potassium, and vitamin B complex) vary depending on the meat category and ingredient used. Current findings highlight the need to redesign existing PBMAs considering nutritional and economic factors to be at par with ABMs. [ABSTRACT FROM AUTHOR]
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- 2024
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29. Effects of feeding whole-cracked rapeseeds, nitrate, and 3-nitrooxypropanol on protein composition, minerals, and vitamin B in milk from Danish Holstein cows.
- Author
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Lokuge, Gayani M.S., Larsen, Mette K., Maigaard, M., Wiking, L., Larsen, L.B., Lund, P., and Poulsen, N.A.
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- *
MILKFAT , *VITAMIN B complex , *VITAMIN B2 , *MILK proteins , *DIETARY fats , *NUTRITIONAL value , *NITRATES , *COWS - Abstract
The list of standard abbreviations for JDS is available at adsa.org/jds-abbreviations-24. Nonstandard abbreviations are available in the Notes. The present study was conducted to assess the individual or combined effects of feeding dietary fat (whole-cracked rapeseed), nitrate, and 3-nitrooxypropanol (3-NOP) on protein profile, mineral composition, B vitamins, and nitrate residues in milk from dairy cows. A total of 48 Danish Holstein cows used in an 8 × 8 incomplete Latin square design were fed 8 factorially arranged diets: (30 or 63 g crude fat/kg DM) × (0 or 10 g nitrate/kg DM) × (0 or 80 mg 3-NOP/kg DM) over 6 periods of 21 d each. In each period, milk samples were collected from individual cows during the third week by pooling milk obtained from 4 consecutive milkings and analyzed for protein profile, including protein modifications, mineral composition, riboflavin, cobalamin, and presence of nitrate residues. Fat supplementation led to an increase in the phosphorylation degree of α S1 -CN by 8.5% due to a decreased relative proportion of α S1 -CN 8P and an increased relative proportion of α S1 -CN 9P and further to a decrease in the relative proportion of α S2 -CN by 2.4%. Additionally, fat supplementation decreased the relative proportions of glycosylated and unglycosylated forms of κ-CN, consequently leading to a 3.6% decrease in total κ-CN. In skim milk, K, Ca, P, and Mg concentrations were altered by individual use of fat, nitrate, and 3-NOP. Feeding nitrate resulted in a 5.4% increase in riboflavin concentration in milk, whereas supplementing 3-NOP increased the cobalamin concentration in milk by 21.1%. The nitrate concentration in milk was increased upon feeding nitrate, but this increased concentration was well below the maximum permissible limit of nitrate in milk (<50 mg/L). Overall, no major changes were observed in milk protein, and mineral compositions by feeding fat, nitrate, and 3-NOP to dairy cows, but the increased riboflavin and cobalamin concentrations by nitrate and 3-NOP, respectively, could be of beneficial nutritional value for milk consumers. [ABSTRACT FROM AUTHOR]
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- 2024
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30. Molecular Mechanisms Linking Genes and Vitamins of the Complex B Related to One-Carbon Metabolism in Breast Cancer: An In Silico Functional Database Study.
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Gálvez-Navas, José María, Molina-Montes, Esther, Rodríguez-Barranco, Miguel, Ramírez-Tortosa, MCarmen, Gil, Ángel, and Sánchez, María-José
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VITAMIN B complex , *PHENOMENOLOGICAL biology , *COMPUTATIONAL biology , *BRCA genes , *SINGLE nucleotide polymorphisms - Abstract
Carcinogenesis is closely related to the expression, maintenance, and stability of DNA. These processes are regulated by one-carbon metabolism (1CM), which involves several vitamins of the complex B (folate, B2, B6, and B12), whereas alcohol disrupts the cycle due to the inhibition of folate activity. The relationship between nutrients related to 1CM (all aforementioned vitamins and alcohol) in breast cancer has been reviewed. The interplay of genes related to 1CM was also analyzed. Single nucleotide polymorphisms located in those genes were selected by considering the minor allele frequency in the Caucasian population and the linkage disequilibrium. These genes were used to perform several in silico functional analyses (considering corrected p-values < 0.05 as statistically significant) using various tools (FUMA, ShinyGO, and REVIGO) and databases such as the Kyoto Encyclopedia of Genes and Genomes (KEGG) and GeneOntology (GO). The results of this study showed that intake of 1CM-related B-complex vitamins is key to preventing breast cancer development and survival. Also, the genes involved in 1CM are overexpressed in mammary breast tissue and participate in a wide variety of biological phenomena related to cancer. Moreover, these genes are involved in alterations that give rise to several types of neoplasms, including breast cancer. Thus, this study supports the role of one-carbon metabolism B-complex vitamins and genes in breast cancer; the interaction between both should be addressed in future studies. [ABSTRACT FROM AUTHOR]
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- 2024
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31. Nutritional symbiosis in ticks: singularities of the genus Ixodes.
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Duron, Olivier
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VITAMIN B complex , *IXODES , *TICKS , *MICROBIAL communities , *MALNUTRITION - Abstract
Ticks feed exclusively on blood. They harbor a functionally analogous microbiome dominated by symbionts that produce B vitamins. This nutritional supplementation by symbionts is critical for the growth of ticks in most genera. Ticks of the genus Ixodes do not harbor the nutritional symbionts found in other tick genera, raising questions about the mechanisms they use to prevent nutritional deficiencies. However, recent investigations have revealed that alternative symbionts with similar biosynthetic capacities are common in Ixodes ticks. These alternative symbionts belong to the order Rickettsiales. Rickettsiales bacteria are best known as virulent pathogens of vertebrates. Rickettsiales symbionts are different: they are mutualistic partners of Ixodes ticks. They dominate microbial communities hosted by Ixodes ticks, influence their physiology, and are required for the production of healthy immatures. Symbiosis with intracellular bacteria is essential for the nutrition of ticks, particularly through the biosynthesis of B vitamins. Yet, ticks of the genus Ixodes , which include major vectors of human pathogens, lack the nutritional symbionts usually found in other tick genera. This paradox raises questions about the mechanisms that Ixodes ticks use to prevent nutritional deficiencies. Nonetheless, Ixodes ticks commonly harbor other symbionts belonging to the order Rickettsiales. Although these obligate intracellular bacteria are primarily known as human pathogens, Rickettsiales symbionts often dominate the Ixodes microbial community without causing diseases. They also significantly influence Ixodes physiology, synthesize key B vitamins, and are crucial for immatures. These findings underscore unique associations between Rickettsiales and Ixodes ticks distinct from other tick genera. [ABSTRACT FROM AUTHOR]
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- 2024
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32. Exploring the impact of gut microbial metabolites on inactivated SARS-CoV-2 vaccine efficacy during pregnancy and mother-to-infant antibody transfer.
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Xi Fu, Bingqian Du, Pei-An Chen, Aga Shama, Baolan Chen, Xi Zhang, Xue Han, Yingxia Xu, Yajie Gong, Xia Zeng, Chongzhen Sun, Wenhan Yang, Xiaohui Xing, Zhongjun Li, Yanyan Fu, Dongyun Ke, Niping Wang, Yun Xia, Yu Sun, and Qingsong Chen
- Subjects
MEDICAL ethics ,VITAMIN B complex ,CORD blood ,CARBOXYLIC acid derivatives ,LIFE sciences - Published
- 2024
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33. A critical review of electrochemical and optical Vitamin B6 sensing: evolution of biosensor platforms based on advanced nanosystems.
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Banan Khojasteh, Mir Hadi, Sohrabi, Hessamaddin, and Majidi, Mir Reza
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WATER-soluble vitamins , *VITAMIN B6 , *COVID-19 , *VITAMIN B complex , *ELECTROCHEMICAL sensors , *BIOELECTROCHEMISTRY - Abstract
Abstract\nHIGHLIGHTSVitamin B6 (VB6) is a member of the water-soluble B vitamins which have a vital performance in nervous system operating activities. VB6 is highly demanded to maintain excellent skin and immune systems in the human body. furthermore, VB6 is tremendously substantial in the functions of some enzymes that participate in the metabolism of proteins, amino acids, etc. The deficiency of VB6 will eventuate in anemic situations and may lead to permanent injuries in the brain. moreover, recent studies disclosed that adequate Vitamin B6 in the human body can decrease the intensity of illnesses such as diabetes, stress, etc., in patients with COVID-19 infections. Thus, the detection of VB6 from real samples is crucial to control the amount of this vitamin in biological fluids and to monitor the pharmaceutical dosage quality. Various analytical approaches have been employed for the VB6 detection in biological and pharmaceutical samples. Although biosensing and sensing approaches hold several obvious advantages such as simplicity, capability for miniaturization, quick response time, etc. from other analytical methods. Hence, through the last decades, designing and fabricating biosensors with sufficient sensitivity and selectivity have been investigated by many researchers in order to detect VB6. The purpose of this review is to illustrate the importance of diverse electrochemical and optical approaches for VB6 detection. Additionally, novel VB6 detection techniques based on electrochemical, optical, and conventional methods have been considerably discussed, and compared with each other. Furthermore, a comprehensive summary of the current limitations and future challenges in VB6 analysis are explained and also create a pathway for subsequent expansions and applications.Vitamin B6 is an essential compound for proper function of human body.Various nanomaterial-based methods such as conational approach, electrochemical biosensing and apta-sensing analyses for Vitamin B6 detection has been developed.Different techniques for detecting of Vitamin B6 have been comprehensively discussed.Various electrochemical sensors fabrication and its application in Vitamin B6 detection with nanomaterials have been assessed.The article points out the recent progress limitations, and also the upcoming tasks in the successful sensor fabrication with the functionalized nanomaterials.Vitamin B6 is an essential compound for proper function of human body.Various nanomaterial-based methods such as conational approach, electrochemical biosensing and apta-sensing analyses for Vitamin B6 detection has been developed.Different techniques for detecting of Vitamin B6 have been comprehensively discussed.Various electrochemical sensors fabrication and its application in Vitamin B6 detection with nanomaterials have been assessed.The article points out the recent progress limitations, and also the upcoming tasks in the successful sensor fabrication with the functionalized nanomaterials. [ABSTRACT FROM AUTHOR]
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- 2024
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34. In vitro Evaluation of DINCH-Plasticized Blood Bags for Red Blood Cell Storage with CPDA-1 Anticoagulant.
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Kim, Hyungsuk, Lee, Kyunghoon, Seo, Soo Hyun, Hong, Yun Ji, Hwang, Sang Mee, Park, Jeong Su, Park, Kyoung Un, and Song, Junghan
- Subjects
- *
ANTICOAGULANTS , *IN vitro studies , *ERYTHROCYTES , *RESEARCH funding , *BLOOD collection , *PHOSPHATES , *SPECTROPHOTOMETERS , *VITAMIN B complex , *PLASTICIZERS , *CITRATES , *HEMOLYSIS & hemolysins - Abstract
Introduction: Di(2-ethylhexyl) phthalate (DEHP) is a plasticizer commonly used in blood bags. Despite its protective effects on red blood cell (RBC) storage, concerns about its reproductive toxicity exist. This study investigated the in vitro quality of RBC concentrates stored in bags using di(isononyl) cyclohexane-1,2-dicarboxylate (DINCH) as an alternative plasticizer. Methods: Using a pool-and-split study design, we produced 20 matched homogenous quintets of RBC concentrates in two DINCH bags and three DEHP bags with citrate phosphate dextrose adenine (CPDA-1) anticoagulant. RBC storage quality was assessed weekly for 35 days. Results: On day 35, the median hemolysis levels in the DINCH bags (0.297–0.342%) were marginally higher (p < 0.05) than the DEHP bags (0.204–0.240%). All DINCH bags showed <0.8% hemolysis. RBCs in the DINCH bags showed increased mean corpuscular volume and decreased eosin 5′ maleimide binding than in the DEHP bags. Higher pO2 and lower pCO2 levels in the DINCH bags indicated better gas permeability than in DEHP bags. Other metabolic parameters were comparable in both bags. Compared to DEHP, DINCH exhibited considerably lower levels of plasticizer leaching into blood bags. Conclusion: The quality of RBC concentrates stored for 35 days in DINCH-plasticized blood bags with CDPA-1 is generally comparable to those in DEHP bags. Hence, DINCH can be a viable alternative to DEHP in blood bags for nonleukoreduced RBC storage even without the use of next-generation additive solutions to improve RBC preservation quality. Plain Language Summary: A plasticizer is a chemical substance added to plastic to increase its flexibility. DEHP is a plasticizer that has been widely used in many products including plastic tubing and bags of medical devices. However, concerns about DEHP-related toxicity have been debated for many years. DEHP has been replaced with other plasticizers in many products, but it is still being used in blood bags due to its protective effect on RBC preservation. DINCH is an alternative plasticizer with a low toxicology profile. This study investigated the quality of RBC concentrates stored in blood bags using DINCH. Twenty sets of five RBC concentrates were produced using two DINCH bags and three DEHP bags with CPDA-1 anticoagulant, and the storage quality was assessed weekly for 35 days. On day 35, the median hemolysis levels in the DINCH bags (0.297–0.342%) were slightly increased than the DEHP bags (0.204–0.240%). However, all DINCH bags showed hemolysis lower than the regulatory limit of 0.8%. DINCH bags exhibited better gas permeability than DEHP bags. Compared to DEHP, DINCH exhibited considerably lower levels of plasticizer leaching into blood bags. Most of the other metabolic parameters were comparable in both bags. The quality of nonleukocyte-reduced RBC concentrates stored for 35 days in DINCH-plasticized blood bags with CDPA-1 is generally comparable to those in DEHP bags. Hence, DINCH can be a viable alternative to DEHP in blood bags for RBC storage, even without the use of next-generation additive solutions to improve RBC preservation quality. [ABSTRACT FROM AUTHOR]
- Published
- 2024
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35. BIOCHEMICAL ALTERATIONS IN PREGNANCY TOXEMIC EWES AND TRIALS OF TREATMENT.
- Author
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GHADA, M. EL KHDER, ISMAIL, EMAN I. M., DARWISH, MOHAMED E., MABROUK, MARWA, ABDELRAHMAN, NOHA, and MOSTAFA, DOAA I. A.
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- *
VITAMIN B complex , *VITAMIN B1 , *PREECLAMPSIA , *BRUXISM , *ASPARTATE aminotransferase - Abstract
The purpose of the current study was to assess the impact of pregnancy toxaemia on hematobiochemical and hormonal changes together with treatment trial of diseased ewes. This study was done on 15, 3-4 years old (5 healthy-10 ewes suffered from pregnancy toxaemia) were divided into 3 groups (5 /group). Gp (1) clinically healthy ewes (control group), Gp (2) diseased ewes received 150 ml of dextrose (25%) (I/V), 100 ml propylene glycol daily for3 sucessive days (orally), 1ml Cal- De-Mag kgm/ bwt and 1 ampole of vitamin B complex IM, Gp (3) diseased ewes treated with same drug and dose used in 2nd group in addition 0.4 unite insulin/kgm bwt (S/C) daily for 3 sucessive days. Urine samples were collected pre-treatment and post treatment for detection of ketone bodies, glucose and protein. Blood was drawn from each subject ewes pre-treatment and at 5 & 10 days post treatment for determination hematobiochemical and hormonal parameters. Pregnancy toxaemic ewes exhibited many signs such as anorexia, depression, disinclined to move - blindness, excessive salivation, teeth grinding, a listening attitude and sternal recumbency. the number of feti in control group was 1.40 but in ewes suffered from pregnancy toxemia were 2.20 in Gp (2) and 2.60 in Gp (3). Urine of diseased ewes revealed presence of ketone bodies, glucoserea and protein. The obtained results demonstrated that pregnancy toxemia induced significant decreases in total erythrocytic count (RBCs), hemoglobin (Hb), paked cell volume % (PCV%), insulin, triiodothyronin (T3), thyroxin (T4), immunoglobulins (IgA, IgM, IgG), super oxide dismutase (SOD), catalase (CAT) glucose, and calcium beside significant increases in cortisol, aspartate aminotransferase (AST), alanin aminotransferase (ALT), urea, creatinine and β-hydroxybutyric acid (β-HBA). Additionally marginal increases in total leukocytic count (WBCs), eosinophils, and lymphocytes coupled with insignifcant decreases in neutrophils, monocytes and basophil when compared with the control ewes were also observed. Teatment of the diseased ewes lead to reterned hemato-biochemical parameters to nearlly nomal level at 10th day post teatment when compared with control ewes. Ewes received insulin in treatment the hematobiochemical parameters was improvement than ewes not received insulin. It was determined that pregnantcy toxaemia caused numerous negative effects on hematobiochemical parameters but treatment with dextrose, propylene glycol, Cal-De-Mag, vitamin B complex and insulin could improve such negative effects [ABSTRACT FROM AUTHOR]
- Published
- 2024
36. Nutritional composition and antioxidant and cancer chemopreventive activities of fruits of Psidium myrtoides (O. Berg).
- Author
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da Costa Cassiano, Camile Zanichelli, Lírio Soares, Karla, Berilli Batista, Patrícia, Marques, Stephano, Maróstica Júnior, Mário Roberto, Junior, Stanislau Bogusz, Núñez, Oscar, Fronza, Marcio, Coutinho Endringer, Denise, and Scherer, Rodrigo
- Subjects
- *
VITAMIN B complex , *FLOUR , *FRUIT , *VITAMIN B1 , *DIETARY fiber , *ORGANIC acids , *FRUIT seeds , *ICE cream, ices, etc. - Abstract
Psidium myrtoides fruits food industries produce by-products such as liqueurs, ice cream, jellies, and juices. However, there needs to be more information about the nutritional composition of fruits, as well as the biological potential, mainly of seed flour. Therefore, the present study aimed to evaluate the nutritional composition and antioxidant and cancer chemopreventive activities of pulp and seed of fruits of Psidium myrtoides. Moisture content, total minerals and mineral profile, total lipids and fatty acids profile, total proteins, dietary fiber (soluble and insoluble) and total carbohydrates were analyzed. Vitamins C and complex B, organic acids and the profile of phenolic compounds were also determined. DPPH and ABTS methods evaluated the antioxidant activity, and cancer chemopreventive activity was evaluated by quinone reductase induction and NF-κB inhibitory activity. The fruits are a good source of thiamine, iron, phosphorus, potassium, fiber, and protein. Linoleic acid was the major fatty acid in both pulp and seed. Quercetin (1600 µg/100g) and pyrogallol (819 µg/100g) were the major phenolic compounds pulp and seed, respectively. The fruits showed strong antioxidant capacity, mainly the seeds, and the ability to induce quinone reductase activity, highlighting a cancer chemopreventive activity. Seed flour has a high potential to enrich food, in addition to valuing agroindustrial by-products, where we can highlight 25%, 13% and 37% of the recommended daily intake for iron (1.6 mg/100g), phosphorus (58 mg/100g) and vitamin B1 (450 µg/100g), respectively, in addition to antioxidant and cancer chemopreventive activities. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
37. Development of Highly Sensitive and Selective Electrochemical Glucose Sensors Based on the Modification of the Surface, Structural, and Morphological Properties of ZnO Using Vitamin-B Complexes.
- Author
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Ali, Feroz, Mari, Riaz Hussain, Dawi, Elmuez, Tahira, Aneela, Halepoto, Imran Ali, Mahar, Ihsan Ali, Rind, Nazir Ahmed, Nangraj, Naveed Abbas, Bhatti, Muhammad Ali, Almani, Khalida Faryal, Nafady, Ayman, Haj Ismail, Abd Al Karim, Vigolo, Brigitte, Qureshi, Sadaf Tabasum, and Ibupoto, Zafar Hussain
- Subjects
ELECTROCHEMICAL sensors ,VITAMIN B complex ,FOURIER transform infrared spectroscopy ,WATER-soluble vitamins ,VITAMIN B12 - Abstract
Non-enzymatic electrochemical glucose sensors are particularly advantageous because of their simplicity, low cost, efficiency, and long storage life. ZnO structures were modified with water-soluble vitamin B12, B9, and B6 complexes in alkaline 0.1 M NaOH solutions to enhance glucose sensing. ZnO samples were hydrothermally synthesized using 5 mg fixed masses of B12, B9, and B6 complexes. X-ray diffraction, scanning electron microscopy, UV-visible spectrometry, and Fourier transform infrared spectroscopy were used to determine crystalline properties, morphology, and optical band gap. Zinc oxide obtained from vitamin B complexes had a hexagonal structure similar to wurtzite, modified nanorods on its surface, and a reduced optical band gap. The molecular weight, size, and number of functional groups vitamins also influenced surface and structural characteristics of ZnO. Zinc oxide from the B12 complex proved excellent for non-enzymatic glucose sensing in alkaline conditions. B12-derived ZnO glucose sensors have a linear range of 0.1 to 10 mM with a detection limit of 0.005 mM. In the glucose sensing process, a satisfactory level of stability, reproducibility, and selectivity was observed. Furthermore, it was found that ZnO derived from B12 had a high electrical conductivity, which facilitated electron transfer during glucose oxidation. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
38. 地下水土著微生物菌群吸收维生素强化 微生物降解烷烃效率分析.
- Author
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徐威庆, 刘 婷, 王吉利, 石宇佳, 迟崇哲, and 张玉玲
- Subjects
VITAMIN B complex ,VITAMIN C ,MICROBIAL growth ,DEBYE temperatures ,ALKANES - Abstract
Copyright of Journal of Jilin University (Science Edition) / Jilin Daxue Xuebao (Lixue Ban) is the property of Zhongguo Xue shu qi Kan (Guang Pan Ban) Dian zi Za zhi She and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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- 2024
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39. The effect of washed rice water on the growth of Pakcoy plants (Brassica rapa chinensis).
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Sulisetijono, Sulisetijono, Muhdhar, Mimien Henie Irawati Al, Putri, Zelvia Aprima, Amalia, Fahrinda Naila, and Abdillah, Racy Rizky
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- *
BOK choy , *VITAMIN B1 , *RICE , *VITAMIN B complex , *ROOT growth , *MICRONUTRIENTS - Abstract
Washed rice water is produced daily and can enhance and stimulate plant root growth. Washed rice water is rich in B vitamins, minerals, and several micronutrients and macronutrients that play a good role in plant growth. Vitamin B1 can convert high carbohydrates into energy in the bioprocess as an intermediary for the formation of auxin and gibberellin hormones. Pakcoy were chosen because they are commonly consumed with a relatively short harvest period of about 25 to 30 days. This study aims to determine whether or not there is an effect and the best concentration of washed rice water on the growth of pakcoy. The research was classified as an experiment conducted using random group designs, with 20 experimental units, four treatments repeated five times and several concentrations as follows. 0 ml/litre of water as variable control (non-treat), 15 ml/litre of water, 20 ml/litre of water, and 25 ml/litre of water. Data was analysed using the Anacova test with a significance value of 0.001 <0.05, meaning that there is an effect of washed rice water on the growth of pakcoy. A pairwise comparison test was conducted with the following significance values. A) root length (0,000<0.05); B) plant height (0,000<0.05); C) stem diameter (0.102>0.05); D) leaf width (0,000<0.05). Furthermore, bivariate analysis was conducted with the following significance values. A) root length (0.003<0.05); B) plant height (0.002<0.05); C) stem diameter (0.062>0.05); D) leaf width (0.001<0.05). It can be concluded that the application of washed rice water with the best concentration, namely 25 ml/litre of water, affects the growth of pakcoy in the parameters of root length, plant height, and leaf width. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
40. Simultaneous estimation of thiamine hydrochloride in the presence of some B vitamins using a first derivative spectrophotometric method of absorption spectra.
- Author
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Yassin, Suhad Abdel Moneim and Al Samarrai, Khalaf F.
- Subjects
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ABSORPTION spectra , *VITAMIN B1 , *DRUGS , *THIAMIN pyrophosphate , *VITAMIN B complex , *CALIBRATION - Abstract
A novel and correct spectrophotometric was progressed for the estimation of VitaminB1 (VitB1) in its pure form and pharmaceutical preparations. The method relies on preparing quadruple mixtures of VitB1,VitB3,VitB5,and VitB6,where the component to be estimated (VitB1) has varying concentrations while the other three components have constant concenntrations. Additionally, a ternary mixture of VitB3, VitB5, andVitB6 with constant concentrations was prepared. The spectra were scanned between 190-400 nm, and the spectra of the ternary mixtures were subtracted from the spectra of the mixtures. The resulting spectra represented the spectra of VitB1. Then, the first derivative of VitB1 spectra was obtained. The peak to the baseline at 254 nm and at 282 nm, Peak area between wavelengths 243-266 nm and 266-306 nm, were proportional to the concentration of VitB1 between 10-90 µg/mL for all calibration curves. Rec% ranged from 97.207-102.621% for all calibration curves, and RSD% values ranged from 2.440-0.029% for intra-day and 0.756-2.836% for inter-day measurements for all calibration curves. LOD and LOQ values ranged between 0.1277-0.7418 µg/ml and 0.4215-2.4481 µg/ml respectively for all calibration curves. The suggested methedwas successfully applied to estimate Thiamine (VitB1) in both pure forms and pharmaceutical preparations. [ABSTRACT FROM AUTHOR]
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- 2024
- Full Text
- View/download PDF
41. B team.
- Author
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Pyne, Louise
- Subjects
FOLIC acid ,VITAMIN B complex ,VITAMIN B12 ,VITAMIN B2 ,PANTOTHENIC acid ,DIETARY supplements ,VITAMIN C ,CONGENITAL disorders - Abstract
This article discusses the importance of B vitamins for sustaining performance and preventing burnout in runners. B vitamins are a family of interconnected nutrients that are crucial for runners as they help with energy production and red blood cell production. Low levels of B vitamins can negatively impact training, leading to fatigue and slower recovery. It is recommended to consume a variety of unprocessed foods to get enough B vitamins, but vegan runners may need to supplement with vitamin B12 due to its absence in plant-based foods. Older runners may also have lower levels of vitamin B12 due to changes in digestion. Taking B vitamins in the morning is recommended as they are involved in energy production and are water soluble. Bright yellow urine is a harmless side effect of excess B vitamins being excreted from the body. The article also provides recommendations for B vitamin supplements. [Extracted from the article]
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- 2024
42. MAGIC PILLS.
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Pyne, Louise
- Subjects
FAT-soluble vitamins ,IRON supplements ,SWEETNESS (Taste) ,BODY fluids ,WATER-soluble vitamins ,VITAMIN B complex - Abstract
This article discusses the importance of supplements in enhancing performance and supporting overall health. It emphasizes the need to carefully read supplement labels to avoid potentially harmful additives and sweeteners. The article also highlights the importance of taking certain nutrients together for optimal absorption and effectiveness. It suggests taking supplements at specific times of the day based on the body's circadian rhythm and avoiding consuming them with tea or coffee. The article concludes by providing a list of important nutrients for runners and the foods in which they can be found. [Extracted from the article]
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- 2024
43. Evaluating the Impact of B Vitamin Supplementation (Soloways™) on Homocysteine and LDL-C Levels in Patients With MTHFR, MTR, and MTRR Polymorphisms. (VITAGEN-H)
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Triangel Scientific and Center of New Medical Technologies
- Published
- 2023
44. An Intervention Study to Investigate the Effect of B-vitamin Supplementation for 2-years on Bone Health (Opti-Age)
- Author
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University of Ulster and Lorraine Brennan, Principle Investigator
- Published
- 2023
45. Prednisolone and Vitamin B1/6/12 in Patients With Post-Covid-Syndrome (PreVitaCOV)
- Author
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University Hospital Tuebingen and University Hospital Schleswig-Holstein
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- 2023
46. A Prospective Clinical Trial to Evaluate the Efficacy and Safety of Neurotropic B-Vitamins in Clinically Diagnosed Peripheral Sensory Polyneuropathy of Different Etiologies.
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- 2023
47. Effect of 4 Weeks Supplementation of a Combination of Vitamin Bs and Taurine on Mental Performance in Healthy Adults
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- 2023
48. The effect of B-vitamins on the prevention and treatment of cardiovascular diseases: a systematic review and meta-analysis.
- Author
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Miao, Ya, Guo, Yihan, Chen, Yixin, Lin, Yijia, Lu, Yan, and Guo, Qihao
- Subjects
- *
CARDIOVASCULAR disease prevention , *HOMOCYSTEINE , *ANGINA pectoris , *CARDIOVASCULAR diseases , *RESEARCH funding , *NON-ST elevated myocardial infarction , *FOLIC acid , *SEX distribution , *VITAMIN B complex , *TREATMENT effectiveness , *META-analysis , *VITAMIN B12 , *AGE distribution , *SYSTEMATIC reviews , *MEDLINE , *CAROTID intima-media thickness , *VITAMIN B6 , *ONLINE information services , *KIDNEY diseases , *DIETARY supplements - Abstract
Context Previous research evaluating the effects in B-vitamins on the prevention and treatment of cardiovascular disease (CVD) has substantial limitations and lacks recently published large prospective studies; hence, conducting an updated meta-analysis is needed. Objective We investigated the association between vitamin B status and human CVD development in order to provide more specific advice about vitamin B intake for those at risk of CVD. Data Sources Relevant articles were identified by JSTOR, PubMed, and ProQuest databases. Data Extraction Key words used to identify the studies included the different combinations of B-vitamins, folate, folic acid, vitamin B6, vitamin B12, homocysteine, cardiovascular disease, stroke, coronary disease, myocardial infarction, and cerebrovascular and transient ischemic attack. The database search was supplemented by hand-searching of reference lists of selected articles. Data Analysis Pooled estimates were calculated from the mean differences using a random-effects model. Results Supplementation with folic acid was reported to have a clinical benefit of significantly reducing carotid intima-media thickness. Higher intakes of folic acid, vitamin B6, and vitamin B12 were generally associated with a lower risk of CVD in the general population, except in those without normal renal function and those with unstable angina or past non–ST-elevation myocardial infarction. Conclusion Vitamin B supplementation resulted in the greatest cardiovascular benefit in those with normal renal function and without unstable angina or non–ST-elevation myocardial infarction recently. Factors such as age, gender, and genetic polymorphisms contribute to varying effects. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
49. Effectiveness of use of group B vitamins in patients with diabetic polyneuropathy: A review
- Author
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Dmitry I. Trukhan and Inna V. Druk
- Subjects
diabetes mellitus ,diabetic polyneuropathy ,treatment ,vitamin b1 ,vitamin b6 ,vitamin b12 ,vitamin b complex ,combilipen® ,Medicine (General) ,R5-920 ,Therapeutics. Pharmacology ,RM1-950 - Abstract
Recent decades have been marked by a rapid increase in the number of patients suffering from diabetes. The development and progression of complications of the disease have the greatest impact on the life prognosis of patients with diabetes mellitus. One of the common complications of diabetes mellitus is diabetic polyneuropathy. According to expert estimates, diabetic polyneuropathy develops in 50% of patients with diabetes mellitus and in 10–30% of patients in a prediabetic state. In domestic clinical recommendations and algorithms, the treatment of diabetic polyneuropathy is considered only in terms of drugs used to treat the painful form of diabetic polyneuropathy. In the recommendations of international experts, pathogenetically oriented pharmacotherapy (alpha-lipoic acid and benfotiamine) occupies an important place. As part of the review, we examined the use of B vitamins for the treatment of diabetic polyneuropathy. We searched for relevant sources in the PubMed and Scopus information databases, including the time period up to 12.04.2024. Experience with the use of B vitamins shows that their maximum effectiveness is achieved when they are used in combination, which is due to the complementary effect of each individual vitamin. The use of a combination of vitamins B1, B6 and B12 for diabetic polyneuropathy normalizes reflex reactions, helps eliminate sensitivity disorders, increases the speed of conduction along nerve fibers, and has a moderate analgesic effect.
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- 2024
- Full Text
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50. DEVELOPMENT OF LENTIL MALT PRODUCTION TECHNOLOGY USING PLASMA-CHEMICALLY ACTIVATED AQUEOUS SOLUTIONS.
- Author
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Kovalova, Olena, Vasylieva, Natalia, Zhulinska, Oksana, Balandina, Iryna, Zhukova, Liubov, Bezpal'ko, Valentyna, Horiainova, Viktoriia, Trybrat, Ruslan, Zazymko, Oleksandr, and Barkar, Yevhen
- Subjects
CEREAL products ,AMINO acid analysis ,VITAMIN B complex ,COMPOSITION of grain ,MALTING ,LENTILS - Abstract
The result of the implemented research is the development of a technology for sprouted lentil (lentil malt) production using cold plasma-treated aqueous solutions. The object of the study was lentil grain. The main technological task is to obtain high-quality lentil malt suitable for producing gluten-free beer and highly nutritious foods. The rationality of using cold plasma-treated aqueous solutions as an intensifier of lentil grain germination process and high-quality lentil malt disinfectant is experimentally proven. It is confirmed that using cold plasma-treated aqueous solutions can accelerate the process of lentil bean moistening by 2 times. The germination indicators of lentils also experienced positive changes, with germination energy increased by 8–16 %, germination capacity by 3–10 %, and sprout length by 12–29 %. An analysis of the amino acid composition of lentil grain and lentil malt was carried out. Thus, the experimental samples had an increased content of amino acids: non-essential by 2.7 %, essential by 3.6 %. There was also an increase in the content of B vitamins (B1, B2, B5, B9), as well as PP and C, which indicates an increased biological value of lentil malt obtained by the presented technologies. In addition, the work noted the steady antiseptic properties of activated aqueous solutions in relation to lentil malt. The intensive technology of obtaining lentil malt can be implemented in the industrial production of malt for the brewing industry. In addition, sprouted lentil beans have health-improving properties and can be used in the production of functional products. The presented technology of lentil bean malting will be in demand in the production of highly nutritious and healthy grain products and fermented beverages. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
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